CN102366437A - Compound dexamethasone ointment and preparation method thereof - Google Patents
Compound dexamethasone ointment and preparation method thereof Download PDFInfo
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- CN102366437A CN102366437A CN201110198801XA CN201110198801A CN102366437A CN 102366437 A CN102366437 A CN 102366437A CN 201110198801X A CN201110198801X A CN 201110198801XA CN 201110198801 A CN201110198801 A CN 201110198801A CN 102366437 A CN102366437 A CN 102366437A
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Abstract
The invention discloses a compound dexamethasone ointment and a preparation method thereof. The compound dexamethasone ointment is prepared from dexamethasone, camphor, menthol, and an emulsion substrate. The product provided by the invention is used for treating local pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis, and chronic eczema. Dexamethasone contained in the product is a glucocorticoid with functions of inflammation resisting and allergy resisting. Menthol and camphor provide functions of regional circulation promoting, and has mild functions of inflammation eliminating, pain relieving, and itching relieving.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of compound recipe dexamethasone ointment machin its preparation method.
Background technology
" psoriasis " of the neurodermatitis and the traditional Chinese medical science, " neurodermatitis " etc. are similar.Because of rheumatism is accumulate skin, due to the stagnation of meridian-QI.Good sending out in cervical region, extremity, waist sacrum, plump with the symmetry pachylosis, violent pruritus is the skin diseases of main performance.Medicine commonly used such as seborrhea health can effectively be treated.Neurodermatitis is claimed lichen chronicus simplex again.It is the chronic dermatosis that turns to characteristic with paroxysmal skin pruritus and skin lichen.Sick for common multiple cutaneous, be more common in youth and adult, the child does not generally fall ill.Summer is multiple or seasonal not obvious.Contact dermatitis is mucocutaneous because the contact external substance, like chemical fibre clothing, and cosmetics, medicine or the like and the inflammatory reaction that takes place.Its clinical characters is the distinct infringement in generation edge in the contact site, and the lighter is an edematous erythema, and heavier person has pimple, water lump even big scar, and more severe patient then can have epidermolysis, even downright bad.If can remove the cause of disease early and suitably handle with doing, can be fast, otherwise possibly be converted into eczema-like dermatitis.Seborrheic dermatitis, chronic process is prone to outbreak repeatedly, and normal companion is folliculitis, blepharitis, and facial normal and acne, rosacea acarid dermatitis are concurrent.The most basic and the effective way of seborrheic dermatitis is to use seborrhea health class medicine to suppress the sebum abnormal secretion, alleviates the inflammatory reaction at skin lesion place, and thoroughly toxin expelling prevents the release of histamine and histamine receptor, plays antipruritic effect.The scalp position begins to be slight flushing patch, on cover canescence bran shape squama, accompany slight pruritus, erythra expansion, visible greasy scales property map shape speckle sheet; Severe patient with ooze out, thick crust, frowziness, can invade whole head.Hair is tear-away, sparse.
Summary of the invention
The invention provides a kind of compound recipe dexamethasone ointment machin its preparation method of treating local pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema, form by dexamethasone, Camphora, Mentholum, emulsion bases; Its prescription is dexamethasone 0.05-0.1%, Camphora 0.5-1.5%, Mentholum 0.5-1.5% by weight percentage, all the other are emulsion bases.
A kind of compound recipe dexamethasone ointment machin its preparation method that the present invention proposes, its prescription preferred version by weight percentage is: dexamethasone 0.075%, Camphora 1%, Mentholum 1%, all the other are emulsion bases.
Among the present invention, described a kind of compound recipe dexamethasone ointment machin its preparation method, described emulsion bases is made up of monostearate, white vaseline, octadecanol, glycerol, sodium lauryl sulphate, ethyl hydroxybenzoate, dimethyl sulfoxide, distilled water; Its prescription is monostearate 20-40%, white vaseline 5-15%, octadecanol 20-35%, glycerol 5-15%, sodium lauryl sulphate 2-10%, ethyl hydroxybenzoate 0.1-0.5%, dimethyl sulfoxide 0.1-2%, distilled water 20-30% by weight percentage.
Among the present invention; Described a kind of compound recipe dexamethasone ointment machin its preparation method, its prescription of described emulsion bases preferred version by weight percentage is: monostearate 25%, white vaseline 10%, octadecanol 25%, glycerol 10%, sodium lauryl sulphate 5%, ethyl hydroxybenzoate 0.3%, dimethyl sulfoxide 0.5%, distilled water 25%.
Hot, the heat, poisonous of Camphora; GUIXIN, spleen channel.Effect dehumidifying parasite killing, warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Cure mainly scabies pruritus, traumatic pain, toothache.Main component is pure gum camphor, is the camphane compounds.Camphora has the effect of stimulating central nervous system system to the central nervous system, and particularly remarkable for high-level center, acts on zona rolandica and brain stem in a large number, causes epileptiform convulsion.The Camphora of general dosage does not have obvious effect to respiratory center, can see something of excitement breathing under the situation about extremely suppressing, and mainly is because the caused reflex excitation of excitement receiver during subcutaneous injection.To the effect of vasomotor center, only when its function was extremely low, the side saw that excitation is arranged, and visceral vessel shrinks and the skin heart diastole, increased blood pressure.Camphora differs to the effect of cardiovascular system report, and the someone thinks that camphor preparations do not have effect to normal myocardium, and high concentration is counter to suppress it.On isolated heart, when only causing depletion, the side sees that excitation is arranged.Also can make increased blood pressure through the vasoactive motorium.So think effective to circulatory collapse or acute heart failure.But the report of this being held suspection or negative attitude is arranged also.
Mentholum is a kind of chemical agent, and Mentholum system is by extracting in the leaf of Herba Menthae and the stem, and white crystal is the main component in Herba Menthae and the lavender quintessence oil.In the world, China and Brazil are main natural Herba Menthae manufacturing country, and the annual production of Oleum menthae all reaches 2000-3000t.Mentholum and racementhol all can be used as the odorant of toothpaste, perfume, beverage and confection etc.As excitants, act on skin or mucosa pharmaceutically, refrigerant itching-relieving action is arranged; Take orally and can be used as carminative, be used for headache and nose, pharynx, laryngitis etc.Its ester is used for spice and medicine.
Among the present invention, described a kind of compound recipe dexamethasone ointment machin its preparation method comprises the steps,
1. take by weighing said raw materials by weight percent medicine dexamethasone, Camphora, Mentholum, fully mix, subsequent use;
2. take by weighing the emulsion bases of said percentage by weight, with water: stearic acid, glycerol, sodium lauryl sulphate, ethyl hydroxybenzoate are put in the evaporating dish, in water-bath, are heated to 60-80 ℃; Again with oil phase: white vaseline, octadecanol, dimethyl sulfoxide are put in the evaporating dish, heat fused in water-bath.Water is added in the above-mentioned oil-phase solution, and the limit edged constantly forward stirs, and to the semi-solid that is creamy white, promptly gets.
3. the material medicine with above-mentioned mix homogeneously adds emulsion-type substrate ointment again through being mixed into ointment, both.
Among the present invention, described a kind of compound recipe dexamethasone ointment is used to treat local pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema.Contained dexamethasone is a glucocorticoid in these article, has antiinflammatory, antianaphylactic effect; Mentholum, Camphora have the local circulation of promotion and slight anti-inflammatory analgetic and itching-relieving action.
Usage: external.Every day 1-2 time, taking a morsel is applied to the affected part, and gently rubs a moment.
The specific embodiment
Below in conjunction with embodiment a kind of compound recipe dexamethasone ointment machin its preparation method of the present invention is described.
Embodiment 1.
Among the present invention, described a kind of compound recipe dexamethasone ointment machin its preparation method comprises the steps,
1. take by weighing said raw materials by weight percent medicine dexamethasone, Camphora, Mentholum, fully mix, subsequent use;
2. take by weighing the emulsion bases of said percentage by weight, with water: stearic acid, glycerol, sodium lauryl sulphate, ethyl hydroxybenzoate are put in the evaporating dish, in water-bath, are heated to 60-80 ℃; Again with oil phase: white vaseline, octadecanol, dimethyl sulfoxide are put in the evaporating dish, heat fused in water-bath.Water is added in the above-mentioned oil-phase solution, and the limit edged constantly forward stirs, and to the semi-solid that is creamy white, promptly gets.
3. the material medicine with above-mentioned mix homogeneously adds emulsion-type substrate ointment again through being mixed into ointment, both.
Case.
Week certain, the man, 57 years old, it was surplus to suffer from local pruritus 1 year, in May, 2008 is through the treatment of this medicine, recovery from illness half a year, it is normal that skin recovers, and do not occur symptom repeatedly so far.
Chen, the woman, 40 years old, the trouble neurodermatitis was many half a year, and in December, 2009 uses the treatment of this medicine, after 2 months, has eliminated disease basically.
Blue certain, the woman, 45 years old, oneself had 5 years to suffer from contact dermatitis, used the treatment of this medicine in March, 2008, through treatment in 1 year, skin recovered normally not see repeatedly so far.
The above; Be merely the preferable specific embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technical staff who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (5)
1. a compound recipe dexamethasone ointment is characterized in that: be made up of dexamethasone, Camphora, Mentholum, emulsion bases; Its prescription is dexamethasone 0.05-0.1%, Camphora 0.5-1.5%, Mentholum 0.5-1.5% by weight percentage, all the other are emulsion bases.
2. a kind of compound recipe dexamethasone ointment according to claim 1 is characterized in that: its prescription preferred version by weight percentage is: dexamethasone 0.075%, Camphora 1%, Mentholum 1%, all the other are emulsion bases.
3. a kind of compound recipe dexamethasone ointment according to claim 1, it is characterized in that: described emulsion bases is made up of monostearate, white vaseline, octadecanol, glycerol, sodium lauryl sulphate, ethyl hydroxybenzoate, dimethyl sulfoxide, distilled water; Its prescription is monostearate 20-40%, white vaseline 5-15%, octadecanol 20-35%, glycerol 5-15%, sodium lauryl sulphate 2-10%, ethyl hydroxybenzoate 0.1-0.5%, dimethyl sulfoxide 0.1-2%, distilled water 20-30% by weight percentage.
4. a kind of compound recipe dexamethasone ointment according to claim 3 is characterized in that: its prescription of described emulsion bases preferred version by weight percentage is: monostearate 25%, white vaseline 10%, octadecanol 25%, glycerol 10%, sodium lauryl sulphate 5%, ethyl hydroxybenzoate 0.3%, dimethyl sulfoxide 0.5%, distilled water 25%.
5. according to a kind of compound recipe dexamethasone ointment machin its preparation method described in the claim 1, it is characterized in that: comprise the steps,
1. take by weighing said raw materials by weight percent medicine dexamethasone, Camphora, Mentholum, fully mix, subsequent use;
2. take by weighing the emulsion bases of said percentage by weight, with water: stearic acid, glycerol, sodium lauryl sulphate, ethyl hydroxybenzoate are put in the evaporating dish, in water-bath, are heated to 60-80 ℃; Again with oil phase: white vaseline, octadecanol, dimethyl sulfoxide are put in the evaporating dish, and heat fused in water-bath adds water in the above-mentioned oil-phase solution, and the limit edged constantly forward stirs, and to the semi-solid that is creamy white, promptly gets;
3. the material medicine with above-mentioned mix homogeneously adds emulsion-type substrate ointment again through being mixed into ointment, both.
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| CN201110198801XA CN102366437A (en) | 2011-07-15 | 2011-07-15 | Compound dexamethasone ointment and preparation method thereof |
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| CN201110198801XA CN102366437A (en) | 2011-07-15 | 2011-07-15 | Compound dexamethasone ointment and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104887767A (en) * | 2015-06-16 | 2015-09-09 | 吉林万通药业集团郑州万通复升药业股份有限公司 | Zisong ointment for treating dermatitis and preparation method of Zisong ointment |
| CN105147706A (en) * | 2015-09-22 | 2015-12-16 | 古东晖 | Skin disinfection and itching-relieving composite and preparation method and application thereof |
| JP2016003208A (en) * | 2014-06-17 | 2016-01-12 | ロート製薬株式会社 | External composition |
| CN105497042A (en) * | 2015-12-09 | 2016-04-20 | 赵爱良 | Ointment for treating eczema and preparation method therefor |
| CN106692403A (en) * | 2015-11-13 | 2017-05-24 | 谭惠娟 | Antipruritic ointment and preparation method thereof |
| CN107913279A (en) * | 2017-11-16 | 2018-04-17 | 钟汝华 | A kind of ointment for treating multiple dermatosis |
| CN108014201A (en) * | 2017-12-29 | 2018-05-11 | 广州仁恒医药科技股份有限公司 | A kind of pharmaceutical composition containing dexamethasone and preparation method thereof |
| CN108392495A (en) * | 2018-05-21 | 2018-08-14 | 高伟玲 | Antipruritic anti-inflammatory ointment |
| CN108853140A (en) * | 2018-07-18 | 2018-11-23 | 豆立忠 | A kind of drug module ointment and preparation method thereof |
-
2011
- 2011-07-15 CN CN201110198801XA patent/CN102366437A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016003208A (en) * | 2014-06-17 | 2016-01-12 | ロート製薬株式会社 | External composition |
| CN104887767A (en) * | 2015-06-16 | 2015-09-09 | 吉林万通药业集团郑州万通复升药业股份有限公司 | Zisong ointment for treating dermatitis and preparation method of Zisong ointment |
| CN105147706A (en) * | 2015-09-22 | 2015-12-16 | 古东晖 | Skin disinfection and itching-relieving composite and preparation method and application thereof |
| CN106692403A (en) * | 2015-11-13 | 2017-05-24 | 谭惠娟 | Antipruritic ointment and preparation method thereof |
| CN105497042A (en) * | 2015-12-09 | 2016-04-20 | 赵爱良 | Ointment for treating eczema and preparation method therefor |
| CN107913279A (en) * | 2017-11-16 | 2018-04-17 | 钟汝华 | A kind of ointment for treating multiple dermatosis |
| CN108014201A (en) * | 2017-12-29 | 2018-05-11 | 广州仁恒医药科技股份有限公司 | A kind of pharmaceutical composition containing dexamethasone and preparation method thereof |
| CN108392495A (en) * | 2018-05-21 | 2018-08-14 | 高伟玲 | Antipruritic anti-inflammatory ointment |
| CN108853140A (en) * | 2018-07-18 | 2018-11-23 | 豆立忠 | A kind of drug module ointment and preparation method thereof |
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Application publication date: 20120307 |