CN105147706A - Skin disinfection and itching-relieving composite and preparation method and application thereof - Google Patents
Skin disinfection and itching-relieving composite and preparation method and application thereof Download PDFInfo
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- CN105147706A CN105147706A CN201510606693.3A CN201510606693A CN105147706A CN 105147706 A CN105147706 A CN 105147706A CN 201510606693 A CN201510606693 A CN 201510606693A CN 105147706 A CN105147706 A CN 105147706A
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Abstract
The invention discloses a skin disinfection and itching-relieving composite and a preparation method and application thereof and relates to the field of medical science. The skin disinfection and itching-relieving composite is prepared from, by weight, sulphamethoxazole, trimethoprim, dexamethasone acetate, camphor, menthol, lauryl sodium sulfate, jasmine essence, starch, dextrin, powdered sugar, preservative, albolene, glyceryl monostearate, glycerol distearates, glycerin, magnesium stearate and stearic acid. A preparation method comprises the steps of oil phase preparation, water phase preparation and ointment preparation. The skin disinfection and itching-relieving composite has powerful and long-acting disinfection and itching-relieving effects and is applicable to skin itch, in particular to intractable skin itch caused by sensitive bacteria of sulfanilamides.
Description
Technical field
The present invention relates to medicine.
Background technology
Along with the development of modern industry, the living environment of people, in variation, suffers from dermopathic people and gets more and more.People often can run into a certain position of body surface or the pruritus at some position, and are difficult to cure, and easily recur, bring very large puzzlement to daily life.And along with antibiotic abuse, the drug resistance of antibacterial, also in increase, is not easy to be killed, further increases the outbreak of skin pruritus like this.
Pruritus be a kind of only have skin pruritus and without primary cutaneous infringement dermatological conditions.According to scope and the position of skin pruritus, be generally divided into general and the large class of limitation two.General pruritus occurring together or onset symptoms often for many general diseases.The exopathogenic factor of general pruritus and environmental factors, as relevant in comprised biological or chemical material incentive in humidity, season, working environment etc.Locality pruritus is common in anus, pudendum or extremity etc., local only conscious pruritus, and there is no erythra, with the passing of time can cause pachyderma, eczema sample changes.
Summary of the invention
For above-mentioned technical problem, the invention provides a kind of skin sterilization anti-pruritic compositions and its production and use.Skin sterilization anti-pruritic compositions of the present invention is made up of the component of following weight portion: Sulfamethoxazole 8 ~ 20 parts, trimethoprim 8 ~ 20 parts, dexamethasone acetate 8 ~ 20 parts, Camphora 3 ~ 15 parts, Mentholum 8 ~ 20 parts, sodium lauryl sulphate 0.5 ~ 8 part, jasmin essence 3 ~ 15 parts, starch 0.5 ~ 7 part, 0.5 ~ 7 part, dextrin, Icing Sugar 0.5 ~ 7 part, antiseptic 0.1 ~ 5 part, white vaseline 1 ~ 10 part, single, double tristerin totally 1 ~ 10 part, glycerol 1 ~ 10 part, magnesium stearate 1 ~ 10 part, stearic acid 0.5 ~ 8 part.
Further, be made up of the component of following weight portion: Sulfamethoxazole 10 ~ 15 parts, trimethoprim 10 ~ 15 parts, dexamethasone acetate 10 ~ 15 parts, Camphora 5 ~ 10 parts, Mentholum 10 ~ 15 parts, sodium lauryl sulphate 1 ~ 5 part, jasmin essence 5 ~ 10 parts, starch 1 ~ 5 part, 1 ~ 5 part, dextrin, Icing Sugar 1 ~ 5 part, antiseptic 0.5 ~ 3 part, white vaseline 2 ~ 7 parts, single, double tristerin totally 3 ~ 8 parts, glycerol 3 ~ 8 parts, magnesium stearate 2 ~ 5 parts, stearic acid 1 ~ 5 part.
Particularly, Sulfamethoxazole 13 parts, trimethoprim 13 parts, dexamethasone acetate 13 parts, Camphora 8 parts, Mentholum 13 parts, sodium lauryl sulphate 3 parts, jasmin essence 8 parts, starch 3 parts, 2 parts, dextrin, Icing Sugar 2 parts, antiseptic 1 part, white vaseline 4 parts, single, double tristerin totally 5 parts, glycerol 5 parts, magnesium stearate 4 parts, stearic acid 3 parts.
Particularly, described Sulfamethoxazole, trimethoprim, dexamethasone acetate, Camphorae and menthue are the fine powder by 150 mesh sieves.
Particularly, described antiseptic is ethyl hydroxybenzoate.
The preparation method of skin sterilization anti-pruritic compositions of the present invention comprises the following steps:
(1). the preparation of oil phase: by formula ratio, by dexamethasone, Camphora, Mentholum, ethyl hydroxybenzoate, white vaseline, single, double tristerin and stearic acid mix homogeneously are also heated to 70 ~ 80 DEG C;
(2). the preparation of aqueous phase: by formula ratio, is heated to 75 ~ 85 DEG C by sodium lauryl sulphate, jasmin essence and glycerol mix homogeneously;
(3). the preparation of ointment: under insulation, the aqueous phase obtained by step (2) is slowly added in the oil phase obtained by step (1), stir while adding, add under stirring after terminating and slowly cool, to adding the Sulfamethoxazole of formula ratio, trimethoprim, starch, dextrin and sugar during room temperature, make it even by colloid mill grinding, to obtain final product.
The application of skin sterilization anti-pruritic compositions of the present invention in preparation treatment skin pruritus, infection medicine.Usage: external.Every day 2 times, take a morsel and be applied to affected part, and gently rub a moment.
In component of the present invention, jasmin essence has conditioning skin, promotes cell regeneration, the particularly skin of dry, responsive, aging, cicatrix and striae gravidarum, keep moisture content and the elasticity of skin, it has function that is lax and warm emotion simultaneously, and stronger anti-melancholy ability can make people in high spirits.
Camphora acrid in the mouth is hot in nature; GUIXIN, spleen channel.Effect is dehumidifying parasite killing, and warming and odynolysis, having one's ideas straightened out, it is dirty to ward off.Be applied to skin and have gentle stimulation and antisepsis.Camphorated oil has analgesia, itching-relieving action, and it also has slight local anesthesia effect.Be generally used for treatment skin infection scabies.
Herba Menthae brain-capacity optionally stimulates the Cold receptor of human body skin or mucosa, produces sense of cold reflection and creeping chill, causes skin mucosa vasoconstriction; Also can cause contraction to the blood vessel of deep tissue in addition, and produce therapeutical effect.External can antiinflammatory, and pain relieving, antipruritic, blood circulation promoting, alleviates edema etc.Mentholum acts on skin or mucosa, has refrigerant itching-relieving action; Add the compliance of patient.Patient is more taken like a shot this compositions.
With the addition of starch, dextrin and sugar in substrate of the present invention, substrate can be made like this to become thick and heavy, extend action time, play long-acting effect.Skin sterilization anti-pruritic compositions white appearance of the present invention is fine and smooth, and fragrant is pleasant, and while sterilization, also have the effect of powerful anti-inflammatory anti-itch, the interpolation of Camphorae and menthue can reduce the consumption of dexamethasone, plays collaborative antipruritic effect.Glycerol and white vaseline have good moistening effect to skin.Be applicable to skin pruritus, be specially adapted to the responsive microbial refractory pruritus of sulfonamides.
In order to understand better and implement, the following detailed description of the present invention.
Detailed description of the invention
preparation embodiment
The preparation method of skin sterilization anti-pruritic compositions of the present invention comprises the following steps:
(1). Sulfamethoxazole, trimethoprim, dexamethasone acetate, Camphorae and menthue are crushed to all by the fine powder of 150 mesh sieves.
(2). the preparation of oil phase: by table 1 formula ratio, is heated to 70 ~ 80 DEG C by dexamethasone, Camphora, Mentholum, ethyl hydroxybenzoate, white vaseline, single, double tristerin and stearic acid mix homogeneously;
(3). the preparation of aqueous phase: by table 1 formula ratio, is heated to 75 ~ 85 DEG C by sodium lauryl sulphate, jasmin essence and glycerol mix homogeneously;
(4). the preparation of ointment: under insulation, the aqueous phase obtained by step (2) is slowly added in the oil phase obtained by step (1), stir while adding, slowly cool after adding end, to adding the Sulfamethoxazole of formula ratio, trimethoprim, starch, dextrin and sugar during room temperature, make it even by colloid mill grinding, to obtain final product.
The each component formula amount of < table 1 is with parts by weight >
The preferred ethyl hydroxybenzoate of described antiseptic.
irritation test embodiment
Tested material: the embodiment 1 ~ 5 that preparation embodiment is obtained and comparative example 1 sample.
Experimenter: Healthy People is totally 36 people, men and women half and half, 20 ~ 30 years old age, meets experimenter and volunteers inclusion criteria.
Test method: tested material is put into speckle examination device, consumption is 0.02g.Control wells is blank (declining any material).The non-stimulated tape sticker of speckle examination device being added with tested material is spread on back or the bent side of forearm of experimenter, gently press with palm and make it to stick equably on skin, continue 24h.30min after removal tested material speckle examination device, observes dermoreaction after impression disappears.If result is negative, after patch test, 24h and 48h observes once respectively again.Reaction result is recorded by table 2 (skin adverse reaction grade scale table).
< table 2 skin adverse reaction grade scale table >
Result of the test is in table 3:
< table 3 removes tested material later evaluation result >
The result that after patch test, 24h and 48h observes respectively is again with table 3.Above result display, skin sterilization anti-pruritic compositions of the present invention is to the effect of human body skin nonirritant.
effect example
Choose the close patient of skin pruritus symptom totally 20 examples, men and women half and half, is divided into two groups, the embodiment 3 using preparation embodiment obtained respectively and comparative example 1 sample.Take a morsel and be applied to affected part, and gently rub a moment, again smear after pruritus recurrence.Use rear tracking to look for effect as follows, smear number of times in every day:
Every day smeared number of times > by < table 4
Can be found out by upper table, by with the addition of starch, dextrin and Icing Sugar, make skin sterilization anti-pruritic compositions of the present invention have more lasting effect, adding the compliance of patient.
case embodiment
Mr. Gu: 68 years old, suffers from anaphylaxis recalcitrant dermal Pruritus.Sick time 4 years, controls bad for a long time.Every day, 2 application preparation embodiment 1 medicines, healed for 30 days afterwards entirely.
Mrs Zhu: 72 years old, suffers from allergic skin Pruritus, sick time 3 months.Every day, 2 application preparation embodiment 2 medicines, healed for 5 days afterwards entirely.
Mr. Li: 45 years old, suffers from recalcitrant dermal Pruritus.Sick time 3 years, controls bad for a long time.Every day, 2 application preparation embodiment 3 medicines, healed for 20 days afterwards entirely.
Mrs Gan: 60 years old, has been stung tens bags by mosquito outside.Horse back repellent antipruritic after application preparation embodiment 4 medicine.
Mrs Gu: 33 years old, has been stung hands by mosquito outside, red and swollen serious.Horse back reducing swelling and alleviating pain after application preparation embodiment 5 medicine.
The present invention is not limited to above-mentioned embodiment, if do not depart from the spirit and scope of the present invention to various change of the present invention or distortion, if these are changed and distortion belongs within claim of the present invention and equivalent technologies scope, then the present invention is also intended to comprise these changes and distortion.
Claims (7)
1. a skin sterilization anti-pruritic compositions, it is characterized in that being made up of the component of following weight portion: Sulfamethoxazole 8 ~ 20 parts, trimethoprim 8 ~ 20 parts, dexamethasone acetate 8 ~ 20 parts, Camphora 3 ~ 15 parts, Mentholum 8 ~ 20 parts, sodium lauryl sulphate 0.5 ~ 8 part, jasmin essence 3 ~ 15 parts, starch 0.5 ~ 7 part, 0.5 ~ 7 part, dextrin, Icing Sugar 0.5 ~ 7 part, antiseptic 0.1 ~ 5 part, white vaseline 1 ~ 10 part, single, double tristerin totally 1 ~ 10 part, glycerol 1 ~ 10 part, magnesium stearate 1 ~ 10 part, stearic acid 0.5 ~ 8 part.
2. skin sterilization anti-pruritic compositions according to claim 1, it is characterized in that being made up of the component of following weight portion: Sulfamethoxazole 10 ~ 15 parts, trimethoprim 10 ~ 15 parts, dexamethasone acetate 10 ~ 15 parts, Camphora 5 ~ 10 parts, Mentholum 10 ~ 15 parts, sodium lauryl sulphate 1 ~ 5 part, jasmin essence 5 ~ 10 parts, starch 1 ~ 5 part, 1 ~ 5 part, dextrin, Icing Sugar 1 ~ 5 part, antiseptic 0.5 ~ 3 part, white vaseline 2 ~ 7 parts, single, double tristerin totally 3 ~ 8 parts, glycerol 3 ~ 8 parts, magnesium stearate 2 ~ 5 parts, stearic acid 1 ~ 5 part.
3. skin sterilization anti-pruritic compositions according to claim 2, is characterized in that being made up of the component of following weight portion: Sulfamethoxazole 13 parts, trimethoprim 13 parts, dexamethasone acetate 13 parts, Camphora 8 parts, Mentholum 13 parts, sodium lauryl sulphate 3 parts, jasmin essence 8 parts, starch 3 parts, 2 parts, dextrin, Icing Sugar 2 parts, antiseptic 1 part, white vaseline 4 parts, single, double tristerin totally 5 parts, glycerol 5 parts, magnesium stearate 4 parts, stearic acid 3 parts.
4. the skin sterilization anti-pruritic compositions according to claims 1 to 3 any one, is characterized in that: described Sulfamethoxazole, trimethoprim, dexamethasone acetate, Camphorae and menthue are the fine powder by 150 mesh sieves.
5. the skin sterilization anti-pruritic compositions according to claims 1 to 3 any one, is characterized in that: described antiseptic is ethyl hydroxybenzoate.
6. prepare a method for the skin sterilization anti-pruritic compositions described in claims 1 to 3 any one, it is characterized in that comprising the following steps:
(1). the preparation of oil phase: by formula ratio, is heated to 70 ~ 80 DEG C by dexamethasone, Camphora, Mentholum, ethyl hydroxybenzoate, white vaseline, single, double tristerin and stearic acid mix homogeneously;
(2). the preparation of aqueous phase: by formula ratio, is heated to 75 ~ 85 DEG C by sodium lauryl sulphate, jasmin essence and glycerol mix homogeneously;
(3). the preparation of ointment: under insulation, the aqueous phase obtained by step (2) is slowly added in the oil phase obtained by step (1), stir while adding, slowly cool after adding end, to adding the Sulfamethoxazole of formula ratio, trimethoprim, starch, dextrin and sugar during room temperature, make it even by colloid mill grinding, to obtain final product.
7. the application of the skin sterilization anti-pruritic compositions according to claims 1 to 3 any one in preparation treatment skin pruritus, infection medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510606693.3A CN105147706A (en) | 2015-09-22 | 2015-09-22 | Skin disinfection and itching-relieving composite and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510606693.3A CN105147706A (en) | 2015-09-22 | 2015-09-22 | Skin disinfection and itching-relieving composite and preparation method and application thereof |
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| CN105147706A true CN105147706A (en) | 2015-12-16 |
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| CN101264070A (en) * | 2008-04-25 | 2008-09-17 | 梁勇才 | Dermatosis-treating medicine and preparation thereof |
| CN102048817A (en) * | 2010-12-21 | 2011-05-11 | 东莞市腾业实业有限公司 | Itch relieving and detoxifying liquid for mosquito and insect biting |
| CN102366437A (en) * | 2011-07-15 | 2012-03-07 | 吉林敖东集团大连药业股份有限公司 | Compound dexamethasone ointment and preparation method thereof |
| CN103251552A (en) * | 2013-05-30 | 2013-08-21 | 成都乾坤动物药业有限公司 | Enrofloxacin cataplasm and preparation method thereof |
| CN103720972A (en) * | 2013-12-26 | 2014-04-16 | 赵鹏 | Traditional Chinese herbal medicinal ointment for treating hyperostosis and preparation method thereof |
| CN104127422A (en) * | 2014-07-17 | 2014-11-05 | 李泽填 | Composition for treating pruritus and acne and preparation method thereof |
| CN104458647A (en) * | 2014-12-10 | 2015-03-25 | 华润三九医药股份有限公司 | Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy |
| CN104622927A (en) * | 2014-12-27 | 2015-05-20 | 江传福 | External sulfanilamide powder |
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2015
- 2015-09-22 CN CN201510606693.3A patent/CN105147706A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101264070A (en) * | 2008-04-25 | 2008-09-17 | 梁勇才 | Dermatosis-treating medicine and preparation thereof |
| CN102048817A (en) * | 2010-12-21 | 2011-05-11 | 东莞市腾业实业有限公司 | Itch relieving and detoxifying liquid for mosquito and insect biting |
| CN102366437A (en) * | 2011-07-15 | 2012-03-07 | 吉林敖东集团大连药业股份有限公司 | Compound dexamethasone ointment and preparation method thereof |
| CN103251552A (en) * | 2013-05-30 | 2013-08-21 | 成都乾坤动物药业有限公司 | Enrofloxacin cataplasm and preparation method thereof |
| CN103720972A (en) * | 2013-12-26 | 2014-04-16 | 赵鹏 | Traditional Chinese herbal medicinal ointment for treating hyperostosis and preparation method thereof |
| CN104127422A (en) * | 2014-07-17 | 2014-11-05 | 李泽填 | Composition for treating pruritus and acne and preparation method thereof |
| CN104458647A (en) * | 2014-12-10 | 2015-03-25 | 华润三九医药股份有限公司 | Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy |
| CN104622927A (en) * | 2014-12-27 | 2015-05-20 | 江传福 | External sulfanilamide powder |
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Application publication date: 20151216 |
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