CN105596364A - Skin disease external application drug, preparation method and uses thereof - Google Patents
Skin disease external application drug, preparation method and uses thereof Download PDFInfo
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- CN105596364A CN105596364A CN201410539442.3A CN201410539442A CN105596364A CN 105596364 A CN105596364 A CN 105596364A CN 201410539442 A CN201410539442 A CN 201410539442A CN 105596364 A CN105596364 A CN 105596364A
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Abstract
The present invention relates to a skin disease external application drug, a preparation method and uses thereof, wherein the external application drug is prepared from white vaseline, triethanolamine, zinc oxide, lanolin, glycerin, stearyl alcohol, soft soap, stearic acid, ethylparaben, distilled water, borneol and clobetasol. The preparation method comprises: taking triethanolamine, soft soap, glycerin and ethylparaben, adding distilled water, dissolving, heating to a temperature of 70-80 DEG C, heating an oil phase comprising stearic acid, vaseline, lanolin and stearyl alcohol to a temperature of 80-80 DEG C, adding the water phase to the oil phase, slowly stirring to achieve a temperature of 50 DEG C, and adding borneol and clobetasol to prepare the emulsion. According to the present invention, the external application drug can cure dermatitis, eczema, solarius dermatitis, insect bite dermatitis and psoriasis, has characteristics of good efficacy, no side effect, rapid cure, short cycle, and has effects of anti-inflammation, anti-allergy, and skin protective acidic cortex stabilizing; and the preparation method has characteristics of simple preparation, high efficiency, and wide raw material source.
Description
Technical field
The invention belongs to external used medicine technical field, relate in particular to one treat dermopathic external used medicine andPreparation Method And The Use.
Background technology
China is populous, suffers from dermopathic patient also many. Medically, skin disease is relevant skinDisease is one of the common disease that has a strong impact on people ' s health, frequently-occurring disease. Skin disease is inside and outside skin is subject toThe impact of factor, its form, 26S Proteasome Structure and Function all change, and produce pathologic process, and at skin tableThe various clinical priority performances of the corresponding generation of face. The dermopathic incidence of disease is very high, mostly low weight, though generalNot unhealthful, but some impacts beauty treatments itches on some bodies, makes one nervous, and minority more severe case is veryExtremely can threat to life. Eczema is a kind of common epidermis being caused by multiple internal and external factor and high dermisInflammatory skin disease, it is generally acknowledged with allergy and have certain relation. Its clinical manifestation have symmetry,The features such as exudative, pruritus dermatopathy, polymorphy and recurrent; Dermatitis and eczema Chang Zuowei synonymBe used to refer to a kind of scytitis, represent that skin is for all things such as chemicals, albumen, bacterium and fungiesThe allergic reaction of matter; Eczema, dermatitis are all skin diseases of a kind of easy recurrence, and treatment needs recurrentMedicine dedicated, can betide any age, any season, the chronic course of disease, easily outbreak repeatedly. Existing marketUpper Chinese patent drug has, but the outstanding product that is of no curative effect, and is zero scattered loose on market mostly,Treatment indication is indefinite, and effect is not good yet. Be used for the treatment of dermopathic external used medicine more, but mostlyStill exist comparatively complexity, the more high deficiency of medical expense of length, therapeutic process for the treatment of time, only haveBetter to single skin disease curative effect, and poor to common skin diseases combined therapy effect, unsatisfactory, existingNot only drug effect is general for the dermopathic external used medicine of some treatments, and medicinal raw material cost is higher, preparation workSkill is more complicated, and preparation efficiency is on the low side, and skin is also attended by toxic and side effect, cures the symptoms, not the disease, cannot be rightSome common skin diseases reach the effect that As the medicine took effect, the symptoms lessened.
Summary of the invention
For above problem, the present invention proposes a kind of good drug efficacy, cure fast, raw materials comes simultaneouslySource is extensive, and preparation is simple, efficiency is high and cost is low, has anti-inflammatory, antiallergy, contributes to stablize skinIn the dermopathic external used medicine for the treatment of and its production and use of the acid cortex of protectiveness.
Technical scheme of the present invention is as follows:
Above-mentioned treatment external use medicine for treating dermatosis thing, it is made up of following raw material: albolene, triethanolamine,Zinc oxide, lanolin, glycerine, 18 alcohol, soft soap, stearic acid, nipagin ethylester, distilled water, iceSheet and clobetasol.
The dermopathic external used medicine of described treatment, wherein: described external used medicine is made up of the raw material of following proportioning:1100 grams of albolene, 100 grams of triethanolamines, 200 grams, zinc oxide, 200 grams, lanolin, glycerine 350Gram, 200 grams of 18 alcohol, 100 grams of soft soaps, 1100 grams of stearic acid, 10 grams of nipagin ethylesters, distillationWater 6660ml, 200 grams of borneols, 4 grams of clobetasols.
One treatment dermopathic external used medicine preparation method, comprise the following steps: 1) get triethanolamine,Soft soap, glycerine, nipagin ethylester, adding distil water dissolves, then is heated to 70 DEG C～80 DEG C; 2) heating is stearicThe oil phase to 70 of acid, vaseline, lanolin, 18 alcohol compositions DEG C～80 DEG C; 3) water is added to fuel tank,Slowly be stirred to 50 DEG C, add borneol and clobetasol, make emulsion.
Treat a purposes for dermopathic external used medicine, can heal dermatitis, eczema, solar dermatitis,Bite by mosquitos type dermatitis and psoriasis, cure rate reaches more than 90%.
The purposes of the dermopathic external used medicine of described treatment, wherein: the emulsifiable paste of described external used medicine is as oneIn kind, the local topical medicine of intensity, has anti-inflammatory, antiallergy, also contributes to stablize in skin simultaneouslyThe acid cortex of protectiveness.
Beneficial effect:
The present invention treats the annoying external used medicine good drug efficacy of skin disease, has no side effect, raw materials wide material sources;Preparation is simple, efficiency is high and cost is low, and the cream drug after preparation is to various dermatitis, eczema, day photosensitivenessDermatitis, bite by mosquitos type dermatitis, psoriasis etc., healing is quick, the cycle is short, and cure rate reaches more than 90%,Can fast reducing patient sense of discomfort, reduce patient's medical expense; Meanwhile, there is anti-inflammatory, antiallergy,Contribute to stablize the acid cortex of protectiveness in skin, increase drug effect.
Detailed description of the invention
The present invention treats dermopathic external used medicine, and its raw material by following proportioning forms:
1100 grams of albolene, 100 grams of triethanolamines, 200 grams, zinc oxide, 200 grams, lanolin, glycerine 350Gram, 200 grams of 18 alcohol, 100 grams of soft soaps, 1100 grams of stearic acid, 10 grams of nipagin ethylesters, distilled water 6660ml,200 grams of borneols, 4 grams of clobetasols, make 10000 grams.
The preparation method of external used medicine of the present invention, comprises the steps:
1) get triethanolamine, soft soap, glycerine, nipagin ethylester, adding distil water dissolves, then is heated to 70℃～80℃；
2) oil phase to 70 of heating stearic acid, vaseline, lanolin, 18 alcohol compositions DEG C～80 DEG C;
3) water is added to fuel tank, be slowly stirred to 50 DEG C, add borneol and clobetasol, make emulsionCan.
The present invention treats dermopathic external used medicine to various dermatitis, eczema, solar dermatitis, bite by mosquitosType dermatitis, psoriasis etc., cure rate reaches more than 90%.
The purposes of by specific embodiment, the present invention being treated to dermopathic external used medicine below is further explainedState.
One, case selection
(1), 18～65 years old age, men and women does not limit;
(2), meet the diagnostic criteria of neurodermatitis and eczema: nerve skin damage shows as light red. Yellowish-brownLook or normal colour of skin size papule circle or the intensive fusion of polygonal be lichen sample become have pigmentation orHypopigmentation, all conscious itch;
(3), skin damage limitation, the gross area is less than 10% of body surface;
(4) while, going to a doctor for the first time, coincident with severity degree of condition total mark is more than or equal to 4 points;
(5), patient's informed consent, exclusion standard A skin damage merge serious bacterium, virus or fungal infectionPerson, B fash is distributed in face, and C has allergies person D to have sternly to this drug component and chemical constitution similar medicineCenter of gravity, liver, kidney function damage person and serious immunologic hypofunction person;
Two, physical data
Selected for 138 example age 18-65 years, the course of disease patient of 2 days～6 years, is divided into 2 at random by selected patientGroup:
A, treatment group 70 examples, male 38 examples, female's 38 examples, chronic eczema 56 examples, neurodermatitis 14 examples;
B, control group 68 examples, male 35 examples, female's 33 examples, chronic eczema 53 examples, neurodermatitis 15 examples;
A group and B group patient's sex, age and state of an illness classification etc. have comparativity.
Three, methods for the treatment of
Treatment group A wipes autogamy ointment outward, all after clean illing skin, medicine thin layer is evenly wiped to affected part outward, andIn soft a moment, every day sooner or later respectively once;
Four, treatment results
A, treatment group 70 examples, treatment 38 examples, cure 24 examples, improve 6 examples, invalid 2 examples, efficient 88.58%;
B, control group 68 examples, treatment 24, cures 26 examples, improves 16 examples, invalid 2 examples, efficient 73.53.
From the above, the emulsifiable paste of external used medicine of the present invention is as a kind of local topical medicine of middle intensity, toolThere are anti-inflammatory, antiallergy, also contribute to stablize the acid cortex of protectiveness in skin simultaneously, increase drug effect.
The present invention treats dermopathic external used medicine good drug efficacy, has no side effect, and raw materials wide material sources, controlMore speed is fast, the cycle is short.
The preparation method of external used medicine of the present invention is simple and efficiency is high, and the cream drug after preparation is to each seed coatInflammation, eczema, solar dermatitis, bite by mosquitos type dermatitis, psoriasis etc., be suitable for propagation and employment.
Claims (5)
1. a treatment external use medicine for treating dermatosis thing, is characterized in that, described external used medicine is by following raw material systemBecome: albolene, triethanolamine, zinc oxide, lanolin, glycerine, 18 alcohol, soft soap, stearic acid,Nipagin ethylester, distilled water, borneol and clobetasol.
2. the dermopathic external used medicine for the treatment of as claimed in claim 1, is characterized in that: described external applicationMedicine is made up of the raw material of following proportioning: 1100 grams of albolene, 100 grams of triethanolamines, zinc oxide 200Gram, 200 grams, lanolin, 350 grams of glycerine, 200 grams of 18 alcohol, 100 grams of soft soaps, stearic acid 1100Gram, 10 grams of nipagin ethylesters, distilled water 6660ml, 200 grams of borneols, 4 grams of clobetasols.
3. a preparation method for the dermopathic external used medicine for the treatment of as claimed in claim 1, its feature existsIn, comprise the following steps:
1) get triethanolamine, soft soap, glycerine, nipagin ethylester, adding distil water dissolves, then is heated to 70℃～80℃；
2) oil phase to 70 of heating stearic acid, vaseline, lanolin, 18 alcohol compositions DEG C～80 DEG C;
3) water is added to fuel tank, be slowly stirred to 50 DEG C, add borneol and clobetasol, make emulsion.
4. a purposes for the dermopathic external used medicine for the treatment of as claimed in claim 1, is characterized in that:Described external used medicine can heal dermatitis, eczema, solar dermatitis, bite by mosquitos type dermatitis and psoriasis,Cure rate reaches more than 90%.
5. the purposes of the dermopathic external used medicine for the treatment of as claimed in claim 4, is characterized in that: instituteState the emulsifiable paste of external used medicine as a kind of local topical medicine of middle intensity, there is anti-inflammatory, antiallergy, withTime also contribute to stablize the acid cortex of protectiveness in skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410539442.3A CN105596364A (en) | 2014-10-14 | 2014-10-14 | Skin disease external application drug, preparation method and uses thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410539442.3A CN105596364A (en) | 2014-10-14 | 2014-10-14 | Skin disease external application drug, preparation method and uses thereof |
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| CN105596364A true CN105596364A (en) | 2016-05-25 |
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| CN201410539442.3A Pending CN105596364A (en) | 2014-10-14 | 2014-10-14 | Skin disease external application drug, preparation method and uses thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578469A (en) * | 2018-06-22 | 2018-09-28 | 高伟玲 | A kind of external medicine composition for treating acne |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1141774A (en) * | 1995-04-11 | 1997-02-05 | 蔡惠明 | Formular of medicine for preventing and curing eczema resulted from baby's napkin |
| CN103877118A (en) * | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | Medicine composition consisting of methylprednisolone aceponate and zinc oxide |
| CN103877117A (en) * | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | Hydrocortisone butyrate and zinc oxide medicine composition |
-
2014
- 2014-10-14 CN CN201410539442.3A patent/CN105596364A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1141774A (en) * | 1995-04-11 | 1997-02-05 | 蔡惠明 | Formular of medicine for preventing and curing eczema resulted from baby's napkin |
| CN103877118A (en) * | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | Medicine composition consisting of methylprednisolone aceponate and zinc oxide |
| CN103877117A (en) * | 2014-03-11 | 2014-06-25 | 天津金耀集团有限公司 | Hydrocortisone butyrate and zinc oxide medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 李冬等: "自制复方氧化锌油膏治疗儿童脓疱疮临床观察", 《甘肃中医学院学报》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578469A (en) * | 2018-06-22 | 2018-09-28 | 高伟玲 | A kind of external medicine composition for treating acne |
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Application publication date: 20160525 |
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