CN112245498A - Antipruritic ointment combining Chinese medicine and western medicine and preparation method thereof - Google Patents
Antipruritic ointment combining Chinese medicine and western medicine and preparation method thereof Download PDFInfo
- Publication number
- CN112245498A CN112245498A CN202011323003.0A CN202011323003A CN112245498A CN 112245498 A CN112245498 A CN 112245498A CN 202011323003 A CN202011323003 A CN 202011323003A CN 112245498 A CN112245498 A CN 112245498A
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- China
- Prior art keywords
- ointment
- medicine
- parts
- western medicine
- traditional chinese
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- 239000003814 drug Substances 0.000 title claims abstract description 81
- 239000002674 ointment Substances 0.000 title claims abstract description 58
- 230000001139 anti-pruritic effect Effects 0.000 title claims abstract description 15
- 239000003908 antipruritic agent Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical group COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 58
- 229960001047 methyl salicylate Drugs 0.000 claims abstract description 29
- 241001071917 Lithospermum Species 0.000 claims abstract description 10
- 229940126678 chinese medicines Drugs 0.000 claims abstract description 8
- 229940126673 western medicines Drugs 0.000 claims abstract description 8
- 235000002566 Capsicum Nutrition 0.000 claims abstract description 7
- 239000006002 Pepper Substances 0.000 claims abstract description 7
- 235000016761 Piper aduncum Nutrition 0.000 claims abstract description 7
- 235000017804 Piper guineense Nutrition 0.000 claims abstract description 7
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract description 7
- 208000003251 Pruritus Diseases 0.000 claims description 36
- 239000006071 cream Substances 0.000 claims description 34
- 239000000052 vinegar Substances 0.000 claims description 30
- 235000021419 vinegar Nutrition 0.000 claims description 30
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- 238000002156 mixing Methods 0.000 claims description 28
- 241000411851 herbal medicine Species 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 23
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
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- 239000000853 adhesive Substances 0.000 claims description 12
- 230000001070 adhesive effect Effects 0.000 claims description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- 239000011505 plaster Substances 0.000 claims description 8
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 241000722363 Piper Species 0.000 claims description 6
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- 238000000034 method Methods 0.000 claims description 5
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 4
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 4
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000005844 Thymol Substances 0.000 claims description 4
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 4
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 3
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- 229920001592 potato starch Polymers 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 239000003871 white petrolatum Substances 0.000 claims description 2
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- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 2
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- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
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- 235000019084 Selinum monnieri Nutrition 0.000 description 1
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- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
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- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
An antipruritic ointment prepared from Chinese medicines and western medicines and a preparation method thereof, wherein the antipruritic ointment comprises the following Chinese medicines and western medicines in parts by weight: 1 minute of folium artemisiae argyi, 1 to 1.2 minutes of fructus cnidii, 1.2 to 1.5 minutes of lithospermum and 1.5 to 2 minutes of pepper; the western medicine component is methyl salicylate ointment which is not filled, and the effective component is methyl salicylate. The antipruritic ointment has the advantages of uniform color, light tan, easy spreading, proper viscosity, fine ointment and proper pH value: 1. the ointment of the invention has the advantages of no layering and no deterioration after long-term storage, 2, good curative effect, 3, no side effect after frequent use and safe use.
Description
Technical Field
The invention relates to the field of medicines, in particular to an antipruritic ointment combining Chinese and western medicines and a preparation method thereof. The invention is to fuse a traditional Chinese medicine external application paste in a western medicine cream matrix by adopting a special infusion method, so that the traditional Chinese medicine original powder application paste can quickly relieve itching without hurting the skin, and the phenomenon of layered deterioration of the traditional Chinese medicine paste and the cream is thoroughly solved. At present, the pure Chinese herbal medicine itching relieving ointment which does not really contain hormone in clinic is very rare, and the Chinese herbal medicine paste ointment is safe, green and free from side effect. Therefore, the development of the itching relieving ointment combining Chinese and western medicines is very suitable for the majority of patients.
Background
Causes of skin itch are various. The following are mainly available: 1. Allergic dermatitis caused by various allergic substances. 2. Including urticaria, eczema, diseases in internal medicine, can cause pruritus, and diseases such as heart disease, respiratory system diseases, immune system diseases, nephropathy, hypertension and diabetes can cause pruritus of skin. 3. The old people often suffer from hypofunction of sebaceous glands, dry skin and other factors, and the skin of the old people is easy to have pruritus symptoms due to the strong wind dry air during the exchange in autumn and winter, and the health of the old people is affected. Is a common skin disease of the old, and the statistical incidence rate is about 10 percent. 4. Skin itch caused by various bacteria mainly refers to inflammation caused by staphylococcus aureus and escherichia coli.
The common medicines for treating skin itch comprise externally applied ointments, such as erythromycin ointment, ciprofloxacin ointment, penicillin ointment and the like, and the antibiotics can reduce the immunity of a human body and generate drug resistance after long-term use, and in addition, anti-inflammatory and anti-allergic medicines comprise prednisone and dexamethasone (floaters) hormones, so that digestive system ulcer, osteoporosis and growth and development influence can be generated after long-term use, the ointment has an inhibiting effect on the growth and development of children, and can also make the human body fat and induce neuropsychiatric symptoms. The skin care product with strong itching relieving function has great harm to skin after being frequently used, and is not suitable for the old. Some current beauty and skin care creams can relieve dry skin but cannot effectively relieve itching of the skin.
In the past, the traditional Chinese medicine powder is added into western medicine cream, but the phenomenon of layered deterioration of the cream cannot be avoided.
Disclosure of Invention
In order to overcome the defects of the common medicine for treating the skin itch, the invention fuses a plurality of traditional Chinese medicine powder into the cream matrix of western medicine by adopting a special infusing method to form the itching relieving medicinal plaster combining the traditional Chinese medicine and the western medicine, can quickly relieve itching without damaging the skin, and thoroughly solves the problem of layered deterioration of the traditional Chinese medicine paste and the western medicine cream.
An antipruritic ointment combining traditional Chinese medicine and western medicine comprises traditional Chinese medicine and western medicine components, and is characterized in that the traditional Chinese medicine components are prepared from the following raw materials: the weight ratio is as follows: 1 minute of folium artemisiae argyi, 1 to 1.2 minutes of fructus cnidii, 1.2 to 1.5 minutes of lithospermum and 1.5 to 2 minutes of pepper; the western medicine component is methyl salicylate ointment which is not filled, and the effective component is methyl salicylate.
The properties of the 4 traditional Chinese medicines are introduced as follows:
1. folium Artemisiae Argyi is leaf of Artemisia argyi of Compositae. Has effects of warming channels, stopping bleeding, dispelling cold, relieving pain, eliminating dampness, and relieving itching.
2. Fructus Cnidii is fruit of cnidium monnieri (L.) kurz belonging to cnidium of Umbelliferae. Has the effects of warming kidney, strengthening yang, eliminating dampness, killing parasites, dispelling pathogenic wind and relieving itching.
3. Radix Arnebiae is root of arnebia euchroma (Royle) Johnst, Lithospermum erythrorhizon (Royle) Johnst and Lithospermum erythrorhizon (Royle) Johnst of Lithospermum of Boraginaceae. Has the effects of clearing heat, cooling blood, promoting blood circulation, removing toxic substances, promoting eruption, killing parasites and relieving itching.
4. Fructus Zanthoxyli is dried mature pericarp of green pepper of Zanthoxylum of Rutaceae. Has effects of warming spleen and stomach, relieving pain, killing parasites and relieving itching. It can be used for treating middle-cold abdominal pain, vomiting and diarrhea due to cold-dampness, abdominal pain due to parasitic infestation, eczema, pruritus vulvae, etc.
A preparation method of antipruritic ointment combining Chinese and western medicines is characterized by comprising the following steps:
1. drying the 4 Chinese herbal medicines, mixing the Chinese herbal medicines according to a proportion, and grinding the mixture into 1000-mesh powder of 800-;
2. soaking the Chinese herbal medicine powder in edible mature vinegar for 12-18 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 6-8;
3. decocting edible starch 4-6% of the medicinal vinegar into edible adhesive, mixing the edible adhesive and the medicinal vinegar, and stirring to obtain brown paste;
4. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment which is not filled, is purchased in the market and can be produced by oneself, and the main effective component of the western medicine cream matrix is methyl salicylate;
5. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1:2-3, stirring uniformly, and blending into a light tan ointment finished product.
The antipruritic ointment has the advantages of uniform color, light tan, easy spreading, proper viscosity, fine ointment, proper pH value, light traditional Chinese medicine faint scent, accordance with the pharmacopoeia sanitary standard, and the like: 1. the ointment of the invention can be stored for a long time without layering and deterioration, and solves the problem that the traditional Chinese medicine can not be added with western medicine cream matrix. 2. The ointment has good curative effect, can improve the skin tissues of the old people when being applied to the pruritus part, can sterilize and relieve itching, and has antibacterial effect on staphylococcus aureus and escherichia coli; has obvious curative effect on skin itch of old people and skin itch caused by bacteria, and can obviously improve allergic dermatitis caused by various allergic substances and itch caused by diseases in medical department. 3. The long-term use does not produce dependence and has no side effect. The precautions are prohibited for use on damaged skin, mouth, eyes, scalp, nostrils and anorectal sites.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments:
the first embodiment is as follows:
the itching relieving medicinal plaster combining Chinese and western medicines comprises the following Chinese medicinal components: the weight ratio is as follows: 1 part of folium artemisiae argyi, 1 part of fructus cnidii, 1.2 parts of lithospermum and 1.5 parts of pepper;
the preparation method comprises the following steps:
1. drying the 4 Chinese herbal medicines in the sun, mixing the Chinese herbal medicines in proportion, grinding the mixture into 1000-mesh powder,
2. soaking the Chinese herbal medicine powder in Shanxi mature vinegar for 12 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 7;
3. decocting Kudzuvine powder 4 wt% of medicinal vinegar with water to obtain edible adhesive, mixing the edible adhesive and medicinal vinegar, stirring, and concocting into brown paste;
4. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment and is purchased in the market;
5. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1:2, stirring uniformly, and blending into a light tan ointment finished product.
The methyl salicylate ointment is purchased from Fujian company, and has methyl salicylate as main effective component and antibacterial effect on Staphylococcus aureus and Escherichia coli.
Example two:
the itching relieving medicinal plaster combining Chinese and western medicines comprises the following Chinese medicinal components: the weight ratio of the Chinese medicinal preparation is 1 minute of folium artemisiae argyi, 1.2 minutes of fructus cnidii, 1.5 minutes of lithospermum and 2 minutes of pepper;
manufacturing method
1. Drying the 4 Chinese herbal medicines in the sun, mixing the Chinese herbal medicines in proportion, grinding the mixture into 800-mesh powder,
2. soaking the Chinese herbal medicine powder in Zhenjiang mature vinegar for 18 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 8;
3. decocting potato starch 6 wt% of medicinal vinegar in water to obtain edible adhesive, mixing the edible adhesive and medicinal vinegar, stirring, and concocting to obtain brown paste;
4. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment and is produced by the user;
5. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1: 3, stirring uniformly, and blending into a light tan ointment finished product.
The methyl salicylate ointment is produced by itself, and the production method is as follows.
The methyl salicylate ointment is prepared by emulsifying the medicinal components and cream matrix; the medicine comprises the following components in parts by weight: 1-5 parts of synthetic camphor, 1-5 parts of borneol, 1-5 parts of menthol, 1-5 parts of methyl salicylate, 1-5 parts of thymol and 1-10 parts of sodium carbonate.
The oil phase components and the weight fraction of the cream matrix are as follows: white vaseline 10-20 parts, liquid paraffin 1-10 parts, glyceryl monostearate 1-10 parts, beeswax 5-15 parts, and ethanol 1-10 parts.
The water phase components and the weight fraction of the cream matrix are as follows: propyl p-hydroxybenzoate for 1-5 min, glycerol for 1-10 min, and distilled water for 30-50 min.
The emulsifier is NP emulsifier 1-10 minutes.
The preparation method comprises the following steps:
1. preparing an oil phase: uniformly mixing the synthetic camphor, borneol, menthol, methyl salicylate and thymol with the oil phase components, and heating to 75-85 ℃ for melting to obtain an oil phase;
2. preparation of an aqueous phase: mixing and dissolving sodium carbonate, water and an emulsifier, and heating to 75-85 ℃ to be used as a water phase;
3. preparing an ointment: and under the condition that the rotating speed of the stirrer is 1000-3000 rpm, gradually adding the water phase into the oil phase until the water phase is completely milky, and slowly stirring to room temperature to obtain the methyl salicylate ointment.
Taking the itching relieving medicinal plaster obtained in the first embodiment as an example, the pH value detection, the stability detection, the cold resistance and heat resistance detection and the skin irritation examination are carried out;
1. and (3) detecting the pH value: under the condition of room temperature, pH test paper is used for measuring the pH value of the antipruritic ointment, and the pH value of the finished product is observed to be neutral;
2. and (3) stability detection: subpackaging the experimental finished product into 3 centrifuge tubes, wherein the centrifugation speeds of the three centrifuge tubes are 4000r/min, and respectively centrifuging for 30min, 40min and 50min, wherein the phenomenon of layering is not found in the itching relieving medicinal plaster by taking whether the phenomenon of layering occurs as an inspection standard;
3. and (3) cold resistance and heat resistance detection: dividing the sample into three groups of a, b and c, parallelly measuring the cold resistance, and keeping the sample at about-5 ℃ for 12 hours; and (3) measuring heat resistance, keeping the temperature at 60 ℃ for half an hour, and observing changes of the appearance, color and coating property of the itching relieving medicinal plaster after the temperature is restored to room temperature, wherein no change is found.
4. Skin irritation study: randomly selecting 8 healthy volunteers, coating the test samples on the skin surface of the arms of the volunteers for skin irritation test, and observing the coated skin after 24h without any adverse reaction of redness, allergy, eruption and blister.
The clinical observation condition of the medicine of the invention and the methyl salicylate ointment on the market for treating skin itch is as follows:
first, ointment of first embodiment of the invention
1. Patient data
The number of outpatients was 30, 19 male, 11 female, 20-30 years old, 2, 31-40 years old, 3, 41-50 years old, 9, and 16 over 50 years old.
2. Initial conditions
Itching is manifested as redness of skin, pimple, or millet-like red rash with blister on the tip, itching and pain after grabbing.
3. Method of treatment
The affected part is wiped with warm water and dried in the air, the ointment is applied to the affected part for 2 times or 3 or 4 times a day, and 5 days of application is a treatment course.
4. Criteria for efficacy assessment
The effect is shown: the skin lesions recovered to normal, and no recurrence was observed for one year.
Improvement: 80% of skin lesions return to normal, and the rest skin lesions have hypertrophic or little liquid exudation, accompanied by itching feeling, but can still be tolerated.
And (4) invalidation: local skin lesions do not meet the criteria of improvement, or do not improve, or even worsen.
5. Therapeutic results
The medicine disclosed by the invention is used for treating 30 patients with skin itch, wherein the result shows 19 patients, and the showing efficiency is 63%; the conversion rate is 30 percent for 9 people; ineffective 2 people account for 7%; the total effective rate is 93%.
Secondly, the methyl salicylate ointment purchased in the market.
1. Patient data
The number of outpatients was 31 in a period of time, 17 men and 14 women, wherein the age was 20-30 years old 1, 31-40 years old 4, 41-50 years old 11 and 15 over 50 years old.
2. The initial situation is the same as the above group.
3. The treatment method was the same as in the above group.
4. The criteria for efficacy assessment were the same as those in the above group.
5. Therapeutic results
The medicine disclosed by the invention is used for treating 31 patients with skin itch, wherein the result shows that 15 patients have obvious effect, and the obvious effect rate is 48%; 7 people are improved, and the improvement rate is 23%; ineffectiveness 9 persons accounted for 29%; the total effective rate is 71%.
Results of the comparative tests: the treatment result of the ointment is obviously higher than that of a comparison group, namely 15 percent points of methyl salicylate ointment purchased in the market, and the total effective rate is higher than that of the comparison group by 22 percent points.
Claims (7)
1. An antipruritic ointment combining traditional Chinese medicine and western medicine comprises traditional Chinese medicine and western medicine components, and is characterized in that the traditional Chinese medicine components are prepared from the following raw materials: the weight ratio is as follows: 1 minute of folium artemisiae argyi, 1 to 1.2 minutes of fructus cnidii, 1.2 to 1.5 minutes of lithospermum and 1.5 to 2 minutes of pepper; the western medicine component is methyl salicylate ointment which is not filled, and the effective component is methyl salicylate.
2. The itching relieving medicinal plaster combining traditional Chinese medicine and western medicine according to claim 1, which is characterized in that the traditional Chinese medicine components are prepared from the following raw materials: the weight ratio is as follows: 1 part of folium artemisiae argyi, 1 part of fructus cnidii, 1.2 parts of lithospermum and 1.5 parts of pepper.
3. The itching relieving medicinal plaster combining traditional Chinese medicine and western medicine according to claim 1, which is characterized in that the traditional Chinese medicine components are prepared from the following raw materials: the weight ratio of the traditional Chinese medicine is 1 minute of folium artemisiae argyi, 1.2 minutes of fructus cnidii, 1.5 minutes of lithospermum and 2 minutes of pepper.
4. A preparation method of antipruritic ointment combining Chinese and western medicines is characterized by comprising the following steps:
A. drying the 4 Chinese herbal medicines, mixing the Chinese herbal medicines according to a proportion, and grinding the mixture into 1000-mesh powder of 800-;
B. soaking the Chinese herbal medicine powder in edible mature vinegar for 12-18 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 6-8;
C. decocting edible starch 4-6% of the medicinal vinegar into edible adhesive, mixing the edible adhesive and the medicinal vinegar, and stirring to obtain brown paste;
D. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment which is not filled, is purchased in the market and can be produced by oneself, and the main effective component of the western medicine cream matrix is methyl salicylate;
E. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1:2-3, stirring uniformly, and blending into a light tan ointment finished product.
5. The preparation method of the antipruritic ointment combined with the traditional Chinese medicine and the western medicine, according to claim 4, is characterized by comprising the following steps:
A. drying the 4 Chinese herbal medicines in the sun, mixing the Chinese herbal medicines in proportion, grinding the mixture into 1000-mesh powder,
B. soaking the Chinese herbal medicine powder in Shanxi mature vinegar for 12 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 7;
C. decocting Kudzuvine powder 4 wt% of medicinal vinegar with water to obtain edible adhesive, mixing the edible adhesive and medicinal vinegar, stirring, and concocting into brown paste;
D. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment and is purchased in the market;
E. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1:2, stirring uniformly, and blending into a light tan ointment finished product.
6. The preparation method of the antipruritic ointment combined with the traditional Chinese medicine and the western medicine, according to claim 4, is characterized by comprising the following steps:
A. drying the 4 Chinese herbal medicines in the sun, mixing the Chinese herbal medicines in proportion, grinding the mixture into 800-mesh powder,
B. soaking the Chinese herbal medicine powder in Zhenjiang mature vinegar for 18 days to obtain medicinal vinegar, wherein the weight ratio of the Chinese herbal medicine powder to the edible mature vinegar is 5: 8;
C. decocting potato starch 6 wt% of medicinal vinegar in water to obtain edible adhesive, mixing the edible adhesive and medicinal vinegar, stirring, and concocting to obtain brown paste;
D. preparing a western medicine cream matrix: the western medicine cream matrix is methyl salicylate ointment and is produced by the user;
E. mixing the traditional Chinese medicine paste and the western medicine cream matrix according to the weight ratio of 1: 3, stirring uniformly, and blending into a light tan ointment finished product.
7. The method for preparing the antipruritic ointment combined with the traditional Chinese medicine and the western medicine according to claim 6, wherein the method for producing the methyl salicylate ointment comprises the following steps:
the methyl salicylate ointment is prepared by emulsifying the medicinal components and cream matrix; the medicine comprises the following components in parts by weight: 1-5 parts of synthetic camphor, 1-5 parts of borneol, 1-5 parts of menthol, 1-5 parts of methyl salicylate, 1-5 parts of thymol and 1-10 parts of sodium carbonate;
the oil phase components and the weight fraction of the cream matrix are as follows: white vaseline 10-20 parts, liquid paraffin 1-10 parts, glyceryl monostearate 1-10 parts, beeswax 5-15 parts, and ethanol 1-10 parts;
the water phase components and the weight fraction of the cream matrix are as follows: 1-5 parts of propyl paraben, 1-10 parts of glycerol and 30-50 parts of distilled water;
1-10 parts of NP emulsifier is used as emulsifier;
the preparation method comprises the following steps:
A. the oil phase preparation method comprises the following steps: uniformly mixing the synthetic camphor, borneol, menthol, methyl salicylate and thymol with the oil phase components, and heating to 75-85 ℃ for melting to obtain an oil phase;
B. the preparation method of the water phase comprises the following steps: mixing and dissolving sodium carbonate, water and an emulsifier, and heating to 75-85 ℃ to be used as a water phase;
C. preparing an ointment: and under the condition that the rotating speed of the stirrer is 1000-3000 rpm, gradually adding the water phase into the oil phase until the water phase is completely milky, and slowly stirring to room temperature to obtain the methyl salicylate ointment.
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| CN114224953A (en) * | 2022-01-06 | 2022-03-25 | 李成 | Itching relieving cream for treating anal itching and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114224953A (en) * | 2022-01-06 | 2022-03-25 | 李成 | Itching relieving cream for treating anal itching and preparation method thereof |
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Application publication date: 20210122 |