CN1141774A - Formular of medicine for preventing and curing eczema resulted from baby's napkin - Google Patents
Formular of medicine for preventing and curing eczema resulted from baby's napkin Download PDFInfo
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- CN1141774A CN1141774A CN 95111003 CN95111003A CN1141774A CN 1141774 A CN1141774 A CN 1141774A CN 95111003 CN95111003 CN 95111003 CN 95111003 A CN95111003 A CN 95111003A CN 1141774 A CN1141774 A CN 1141774A
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- vitamin
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- silicone oil
- vaseline
- alumen
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Abstract
The formula of the composition for preventing and curing infantile diaper eczema includes (wt%) vaselline (30.0-70.0%), lanolin (20.0-40.0%), paraffin oil, silicon oil, vitamin AD (each 1.0-10.0%), borneol, alum (each 0.1-5.0%), nipagin A and nipagin C (each 0.1-2.0%); or vaselline (10.0-60.0%), zinc oxide (10.0-60.0%), vitamin AD, silicon oil, glyceryl monostearate, paraffin oil, ceresin (each 0.5-10.0%), borneol (0.1-10.0%), alum, magnesium stearate, propylparaben, benzene carbonic acid and benzoic alcohol (each 0.1-5.0%). Said invention can resist inflammation, allergic reaction and itching, etc. and has no acute toxicity, anaphylaxis and irritation.
Description
What the present invention relates to is a kind of prescription that is used to prevent and treat baby diaper eczema.
At present, baby diaper eczema is one of baby's common disease that sickness rate is very high in the world, and is especially higher at developing countries' sickness rate.China belongs to the high region of disease of baby diaper eczema, especially in vast rural area, and sickness rate nearly 90%.Its cause of disease is commonly considered as owing in time do not changed by the wetted diaper of defecation, and carbamide is produced ammonia by the bacterial decomposition in the feces in the urine, and chafe makes its inflammation.In addition, diaper does not rinse or for a long time with blanket or Polypropylence Sheet, makes baby buttocks be in humid tropical condition, and this also is another major reason that causes diaper rash.This disease the lighter skin rubefaction, pimple, herpes or secondary infection ulcer etc. appear in weight person.Often show as and cry incessantly, influence the necessary enough sleeps of baby, thereby have influence on baby's health.
Many with talcum powder etc. when preventing clinically; contain the calamine liniment of 5% neomycin or use zinc oxide paste according to the state of an illness is commonly used during morbidity; when the purulence secondary infection is arranged; can put the nystatin cold cream on the skin; or 1～2% chemical drugs such as Gentian Violet liquid treatment; the pure therapeutic value of this quasi drugs tool, and the effect of unprotect and nourishes rough skin.Consider that structure is not fine and close as yet between neonate and less infant skin epidermis and the corium, keratinization of epidermis hypoplasia, reasons such as resistance difference, when prevention and treatment baby diaper eczema, should try one's best and not use chemical agent,, must eradicate because of using the imbalance of the normal flora that antibiotic or hormone may cause to avoid the stimulation and the toxic and side effects of chemical agent to the tender skin of children, thereby cause epidermis to lose natural flora barrier, and cause the secondary disease.So need efficient skin protection and determined curative effect and several non-irritating baby diaper eczema to prevent and therapeutic agent on clinical and the market.
The purpose of this invention is to provide the prescription that two classes are used to prevent and treat baby diaper eczema.
Prescription A is an active substance with vitamin AD, Borneolum Syntheticum and Alumen, is aided with skin protection active ingredients such as silicone oil, lanoline again and nourishes infant skin, prevention efficiently and can treat baby diaper eczema; Prescription B is an active substance with zinc oxide, vitamin AD, Borneolum Syntheticum and Alumen, be aided with active ingredients such as silicone oil again, can nourish infant skin, efficiently the treatment and can prevent infantile eczema, promote the convergence of skin ulcer face and the growth of skin, and two class prescriptions are organized several nonirritants to infant skin.
The objective of the invention is to be achieved through the following technical solutions.
It is 30.0～70.0% vaseline that the A that fills a prescription among the present invention comprises percentage by weight, 20.0～40.0% lanoline, 1.0～10.0% paraffin oil, 1.0～10.0% silicone oil, 1.0～10.0% vitamin AD, 0.1～5.0% Borneolum Syntheticum, 1.0～5.0% Alumens, 0.1～2.0% Metagin, 0.1～2.0% nipalgin second.Above-mentioned each compositions in weight percentage taken by weighing insert in the suitable vessel, be placed on and be heated to fine melt in the water-bath, constantly be stirred to and coagulate promptly.
It is 10.0～60.0% vaseline that the B that fills a prescription among the present invention comprises percentage by weight, 10.0～60.0% zinc oxide, 0.5～10.0% vitamin AD, 0.5～10.0% silicone oil, 0.5～10.0% glyceryl monostearate, 0.5～10.0% paraffin oil, 0.5～10.0% ceresine, 0.1～10.0% Borneolum Syntheticum, 0.1～5.0% Alumen, 0.1～5.0% magnesium stearate, 0.1～5.0% propylparaben, 0.1～5.0% benzoic acid, 0.1～5.0% benzyl alcohol.With above-mentioned each compositions in weight percentage, earlier vaseline, vitamin AD oil, silicone oil, glyceryl monostearate, paraffin oil, ceresine, Borneolum Syntheticum, propylparaben, benzoic acid, benzyl alcohol are mixed, in water-bath, be heated to molten, add zinc oxide, magnesium stearate and Alumen powder, constantly be stirred to and coagulate promptly.
Advantage of the present invention is: prescription A has the nourishing infant skin, suppresses noxious bacteria effectively and prevents the decomposition of carbamide, and the effect of heat-clearing and toxic substances removing is arranged, and can prevent the generation of baby diaper eczema efficiently, and can treat baby diaper eczema; Prescription B has the nourishing infant skin, suppresses the decomposition of carbamide effectively, clearing heat and expelling damp, and inhibiting bacteria and diminishing inflammation promotes the convergence of skin ulcer face and is beneficial to the effect of skin growth, can treat effectively and can prevent baby diaper eczema.Above-mentioned two prescriptions are to several nonirritants of baby's tender skin of children.
Below in conjunction with example advantage of the present invention is described further.
Prescription A contains: 52.0% vaseline, 31.2% lanoline, 5.1% paraffin oil, 5.1% silicone oil, 4.1% vitamin AD, 1.0% Borneolum Syntheticum, 0.5% Alumen, 0.4% Metagin, 0.6% nipalgin second.Prescription B contains: 34.3% vaseline, 34.2% zinc oxide, 4.9% vitamin AD, 4.9% silicone oil, 4.9% glyceryl monostearate, 4.9% paraffin oil, 4.9% ceresine, 2.0% Borneolum Syntheticum, 1.0% Alumen, 1.0% magnesium stearate, 1.0% propylparaben, 1.0% benzoic acid, 1.0% benzyl alcohol.By the preparation method in the aforementioned techniques solution it is made A and B prescription.It is carried out pharmacodynamics and toxicity study detection, and its result is as follows:
1. prescription A, B two samples, the ear swelling tool significant inhibitory effect to due to the mouse knoting oil confirms that A has prevention to have the treatment inflammatory effect concurrently, the B sample has antiinflammatory to have the prevention of inflammation effect concurrently.
2. prescription A, B two samples are inhibited to Mice Auricle skin delayed hypersensitivity, prove that the A sample has prevention to have treatment effect hypersensitive concurrently, and the B sample has antiallergic to have the effect of Polyglucan concurrently.
3. prescription A, B two samples can significantly improve the threshold values of Cavia porcellus histamine phosphate, prove that A, B two samples have tangible itching-relieving action.
4. complete and surperficial A and the B that applies various dose respectively of damaged skin of rat observed 14 days continuously, and toxic reaction and death appear in none animal as a result, show its no skin acute toxicity.
5. prescription A and two samples of B are observed through the coating that once reaches repeatedly of Cavia porcellus complete sum damaged skin, and the skin irritation reaction does not all appear in the result.
6. prescription A and two samples of B anaphylaxis do not occur after guinea pig skin applies repeatedly, show that this product external can not cause allergic reaction.
Above-mentioned result of study shows that prescription A of the present invention and B all do not have acute toxicity, anaphylaxis and zest to skin, and external is safe and reliable.A prescription can prevention of inflammation, allergy and scratch where it itches have antiinflammatory, antiallergic and itching-relieving action concurrently; Good antiinflammatory, antiallergic and the antipruritic activity of B prescription tool has preventive effect concurrently.Two classes prescription can be used as control baby diaper eczema.
Claims (4)
1. prescription A who is used to prevent and treat baby diaper eczema, comprising percentage by weight is 30.0～70.0% vaseline, 20.0～40.0% lanoline, 1.0～10.0% paraffin oil, 1.0～10.0% silicone oil, 1.0～10.0% vitamin ADs, 0.1～5.0% Borneolum Syntheticum, 0.1～5.0% Alumen, 0.1～2.0% Metagin, 0.1～2.0% nipalgin second.Above-mentioned each group is taken by weighing by weight percentage in suitable vessel, be placed on and be heated to fine melt in the water-bath, constantly be stirred to and coagulate and get.
2. prescription B who is used to prevent and treat baby diaper eczema, comprising percentage by weight is 10.0～60.0% vaseline, 10.0～60.0% zinc oxide, 0.5～10.0% vitamin AD, 0.5～10.0% silicone oil, 0.5～10.0% glyceryl monostearate, 0.5～10.0% paraffin oil, 0.5～10.0% ceresine, 0.1～10.0% Borneolum Syntheticum, 0.1～5.0% Alumen, 0.1～5.0% magnesium stearate, 0.1～5.0% propylparaben, 0.1～5.0% benzoic acid, 0.1～5.0% benzyl alcohol.With above-mentioned each compositions in weight percentage, earlier with mixing such as vaseline, vitamin AD, silicone oil, glyceryl monostearate, paraffin oil, ceresine, Borneolum Syntheticum, propylparaben, benzoic acid and benzyl alcohol, in water-bath, be heated to molten, add zinc oxide, magnesium stearate and Alumen powder, constantly be stirred to and coagulate promptly.
3. the prescription A that narrates according to claim 1, it is characterized in that comprising percentage by weight respectively is 52.0% vaseline, 31.2% lanoline, 5.1% paraffin oil, 5.1% silicone oil, 4.1% vitamin AD, 10% Borneolum Syntheticum, 0.5% Alumen, 0.4% Metagin, 0.6% nipalgin second.Said components is taken by weighing in suitable vessel, be placed on and be heated to fine melt in the water-bath, constantly be stirred to and coagulate promptly.
4. the prescription B that narrates according to claim 2, it is characterized in that comprising percentage by weight respectively is 34.30% vaseline, 34.2% zinc oxide, 4.9% vitamin AD, 4.9% silicone oil, 4.9% glyceryl monostearate, 4.9% stone silicone oil, 4.9% ceresine, 2.0% Borneolum Syntheticum, 1.0% Alumen, 1.0% magnesium stearate, 1.0% propylparaben, 1.0% benzoic acid, 1.0% benzyl alcohol.By weight percentage, take by weighing mixing such as vaseline, vitamin AD oil, silicone oil, glyceryl monostearate, paraffin oil, ceresine, Borneolum Syntheticum, propylparaben, benzoic acid and benzyl alcohol earlier, in water-bath, be heated to molten, add zinc oxide, magnesium stearate and Alumen powder, constantly be stirred to and coagulate promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95111003 CN1141774A (en) | 1995-04-11 | 1995-04-11 | Formular of medicine for preventing and curing eczema resulted from baby's napkin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 95111003 CN1141774A (en) | 1995-04-11 | 1995-04-11 | Formular of medicine for preventing and curing eczema resulted from baby's napkin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1141774A true CN1141774A (en) | 1997-02-05 |
Family
ID=5078327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 95111003 Pending CN1141774A (en) | 1995-04-11 | 1995-04-11 | Formular of medicine for preventing and curing eczema resulted from baby's napkin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1141774A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032155A2 (en) * | 1998-12-04 | 2000-06-08 | Johnson And Johnson Consumer Companies, Inc. | Skin care compositions containing zinc salts and retinoids |
| EP1275403A1 (en) * | 2001-07-10 | 2003-01-15 | Lin I. Shan | Additive for a sanitary napkin and a method of adding the same |
| WO2004014331A1 (en) * | 2002-08-08 | 2004-02-19 | Kimberly-Clark Worldwide, Inc. | Enzyme blocking skin protectant cream |
| CN105596364A (en) * | 2014-10-14 | 2016-05-25 | 熊英 | Skin disease external application drug, preparation method and uses thereof |
-
1995
- 1995-04-11 CN CN 95111003 patent/CN1141774A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000032155A2 (en) * | 1998-12-04 | 2000-06-08 | Johnson And Johnson Consumer Companies, Inc. | Skin care compositions containing zinc salts and retinoids |
| WO2000032155A3 (en) * | 1998-12-04 | 2000-11-23 | Johnson & Johnson Consumer | Skin care compositions containing zinc salts and retinoids |
| EP1275403A1 (en) * | 2001-07-10 | 2003-01-15 | Lin I. Shan | Additive for a sanitary napkin and a method of adding the same |
| WO2004014331A1 (en) * | 2002-08-08 | 2004-02-19 | Kimberly-Clark Worldwide, Inc. | Enzyme blocking skin protectant cream |
| US6932976B2 (en) | 2002-08-08 | 2005-08-23 | Kimberly-Clark Worldwide, Inc. | Enzyme blocking skin protectant cream |
| CN105596364A (en) * | 2014-10-14 | 2016-05-25 | 熊英 | Skin disease external application drug, preparation method and uses thereof |
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