CN104146939A - Hip cream and preparation method thereof - Google Patents

Hip cream and preparation method thereof Download PDF

Info

Publication number
CN104146939A
CN104146939A CN201410403991.8A CN201410403991A CN104146939A CN 104146939 A CN104146939 A CN 104146939A CN 201410403991 A CN201410403991 A CN 201410403991A CN 104146939 A CN104146939 A CN 104146939A
Authority
CN
China
Prior art keywords
hip pad
mixture
mesh sieves
cream
hip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201410403991.8A
Other languages
Chinese (zh)
Inventor
陈平
严常开
林刚
周丽
孙金龙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayinglong Pharmaceutical Group Co Ltd
Original Assignee
Mayinglong Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayinglong Pharmaceutical Group Co Ltd filed Critical Mayinglong Pharmaceutical Group Co Ltd
Priority to CN201410403991.8A priority Critical patent/CN104146939A/en
Publication of CN104146939A publication Critical patent/CN104146939A/en
Pending legal-status Critical Current

Links

Landscapes

  • Cosmetics (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

The invention discloses a hip cream and a preparation method thereof. Effective components of the hip cream comprise pearl, amber, VE, oat kernel oil, chamomile butter, Citrus tangerine butter and basic zinc carbonate. The preparation method comprises the following steps: carrying out airflow crushing on pearl and amber, and mixing with other effective components, a cream matrix, a thickening agent and a stabilizer to prepare a product. A submicron powder technology adopted to process main components in the above formula makes the effective components of the product easily permeate skin mucous membranes in order to enhance the action effect. The hip cream can promote healing of light red hip (diaper rash) and perianal redness, has a certain prevention and treatment effect on the red hip and perianal redness, is safe, has no irritation, and is very suitable for infants to use.

Description

A kind of hip pad cream and preparation method thereof
Technical field
The present invention relates to a kind of hip pad cream of preventing and treating infant diaper rash and preparation method thereof.
Background technology
Diaper rash (being commonly called as red hip) is multiple is born in the infant with diaper, and be accompanied by the use of diaper and occur simultaneously, be the common skin problem of infant.Particularly use the infant of diaper and the paper napkin more easily to obtain diaper rash, symptom is child's buttocks redness, and diaper position has lump around.If around red of diaper position or also have pink parcel around mouth, diaper rash may develop into yeast diaper rash, need to treat with local bactericidal medicine.
The reason that produces diaper rash has: clean not diligent, moist warm heat, cleans with soap and water too frequently, and diaper friction causes skin of buttock impaired, the stimulus object in feces or urine, the antibacterial in feces, diarrhoea etc.
The use of diaper is widely used, but the diaper rash thereupon bringing becomes one of the most common skin problem of infant, and no matter south is still northern, and each infant has the experience of long diaper rash substantially.
Hip pad cream can protect the buttocks of infant away from diaper rash, and the main component of hip pad cream is oils and fats, and the buttocks that evenly spreads upon infant can form layer protecting film on skin, and isolated skin and urine, avoid urine chafe well.In some hip pad cream, add anti-inflammation composition, when infant hip is slightly rubescent or damaged, used, can play certain protection and therapeutical effect.
On market, common hip pad cream is generally not useable for more serious diaper rash now, and in the time that skin injury appears in diaper rash, the chemosynthesis character of Yin Putong hip pad cream, has certain stimulation to damaged skin, and serious diaper rash can not continue to use.For a long time, and at treatment infant diaper rash and purple grass oil, the baby buttocks articles for use that possess certain Clinical Basis have no report to the historical origin that Chinese medicine is applied to cosmetics, skin care item and health product.
Summary of the invention
Can not be used in order to solve common hip pad cream in prior art the technical problem that more serious diaper rash prevents and treats, the invention provides the obvious and safe and non-stimulating hip pad cream of a kind of new effect.
Hip pad cream provided by the invention, effective ingredient comprises Margarita, succinum, VE (tocopherol acetas) Herba bromi japonici core oil, Flos Matricariae chamomillae fat, large tangerine fat and basic zinc carbonate.
In side pearl whitening take off black, removing toxic substances and promoting granulation; Succinum acupuncture-stimulating blood stasis dispersing, promoting blood circulation and detumescence; The antipruritic Shu Min of Herba bromi japonici core oil; Flos Matricariae chamomillae fat (Chamomile butter) antiphlogistic and bactericidal effect is remarkable, contributes to healing of wound; Large tangerine fat (Angerine Butter) champignon is releived, and has remarkable skin spreading property and moistening effect, and its fragrant and sweet tempting abnormal smells from the patient can stimulate the sense organ of user.Plurality of active ingredients synergism, effectively dissipating blood stasis for subsidence of swelling, the maintenance of releiving, remarkable to removing infant diaper rash and purple grass oil symptom effect.Mentioned component all can be bought commercial goods, and for example Flos Matricariae chamomillae fat and large tangerine ester can be purchased from Biochemica companies of the U.S..
Preferably, each effective ingredient parts by weight of described hip pad cream are as follows:
Preferably, above-mentioned hip pad cream also comprises emulsifiable paste matrix, thickening agent and stabilizing agent.
Preferably, above-mentioned hip pad cream also contains the effective ingredient of following parts by weight:
Wherein, oleogel is for conventional daily use chemicals formula, as skin-care agent, while is for increasing the stability of product, all materials with this function are all applicable to the present invention, preferably pharmacopeia level oleogel, and the best is the product of German Chinese sage (H & R) company: 11101 by gel, and product composition is liquid paraffin, hydrogenation (styrene/isoprene) copolymer.Adding of above adjuvant, can make product more gentle soft and smooth, fits tightly with skin, is conducive to the abundant infiltration of ingredient.
Preferably, above-mentioned hip pad cream also contains the effective ingredient of following parts by weight:
Three mountain Yu essence 10-40;
Bisabolol 1-10.
Three mountain Yu essences can be improved the outward appearance of hip pad cream, make the quality of hip pad cream more stable.Bisabolol can obviously improve the zest of hip pad cream to child's skin, and prevention and minimizing are irritated.
In the time that the adjuvant of hip pad cream is liquid paraffin, microwax, trihydroxy stearin and oleogel, its preparation method is as follows:
(1) respectively Margarita and succinum are pulverized, excessively after 100 mesh sieves, mix with basic zinc carbonate, grind, cross 160 mesh sieves, comminution by gas stream to 200 order, obtains mixture a;
(2) mixture a mixes with 90-300 part liquid paraffin, is heated to 80-85 DEG C, is uniformly dispersed, and crosses while hot 120 mesh sieves, and sucking filtration is to emulsion tank;
(3) after microwax fragmentation, add successively in pretreatment tank with Flos Matricariae chamomillae fat and large tangerine fat, fusing disperses completely, crosses while hot 120 mesh sieves, sucking filtration is to emulsion tank step (2) Suo Shu, and maintenance temperature is 80-85 DEG C, more than homogenizing 10min, stir 15-20min, obtain mixture b;
(5) mixture b is cooled to 65-70 DEG C, and oleogel is added wherein, and homogenizing 5-10min, stirs, and while being cooled to 60-65 DEG C, adds the trihydroxy stearin disperseing with remaining liq paraffin, homogenizing, and mixture c stirs to obtain;
(6) mixture c is cooled to 50 DEG C, adds successively VE, Herba bromi japonici core oil, stirs, and obtains hip pad cream product.
In the time that the adjuvant of hip pad cream is liquid paraffin, microwax, trihydroxy stearin, oleogel, three mountain Yu essences and bisabolol, its preparation methods steps is as follows:
(1) respectively Margarita and succinum are pulverized, excessively after 100 mesh sieves, mix with basic zinc carbonate, grind, cross 160 mesh sieves, comminution by gas stream to 200 order, obtains mixture a;
(2) obtain mixture a and mix with 90-300 part liquid paraffin, be heated to 80-85 DEG C, be uniformly dispersed, cross while hot 120 mesh sieves, sucking filtration is to emulsion tank;
(3) after microwax fragmentation, add successively in pretreatment tank with Flos Matricariae chamomillae fat, large tangerine fat and three mountain Yu essences, fusing disperses completely, crosses while hot 120 mesh sieves, and sucking filtration, to emulsion tank step (2) Suo Shu, obtains mixtures II;
(4) maintenance of the mixtures II in emulsion tank temperature is 80-85 DEG C, more than homogenizing 10min, stir 15-20min, be cooled to 65-70 DEG C, oleogel is added wherein, homogenizing 5-10min, stirs, while being cooled to 60-65 DEG C, add the trihydroxy stearin disperseing with remaining liq paraffin, homogenizing, stirs, and obtains mixtures III;
(5) mixtures III is cooled to 50 DEG C, adds successively VE, Herba bromi japonici core oil, continues to be cooled to after 40 DEG C, then adds bisabolol, is uniformly mixed, and obtains hip pad cream product.
The present invention has following beneficial effect:
1, prescription scientific and precise, exact efficacy have no side effect; Formula safety is gentle non-stimulated, is applicable to very much infant and uses.
2, adopt Study on Supermicro-pulverization of Traditional Chinese Drugs technology to process the key component in formula, make drug micronization, be easy to, through mucocutaneous, strengthen the action effect of main effective ingredient.
3, Clinical observation shows: hip pad cream of the present invention can promote the healing of slight diaper dermatitis (diaper rash) and purple grass oil, and diaper dermatitis (diaper rash) and purple grass oil are had to certain preventive and therapeutic effect.
4, toxicology test result shows: this product avirulence, and safe and non-stimulating.Rabbit repeatedly irritation test result shows: continuous use of the present invention 14 days, and animal subject is without whole body poisoning manifestations, and skin irritation performance is also without obvious erythema and edema.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, can be implemented, but illustrated embodiment is not as a limitation of the invention so that those skilled in the art can better understand the present invention also.As not doing specified otherwise, ingredient consumption is parts by weight.
The constituent of hip pad cream and consumption:
The preparation process of hip pad cream:
(1) respectively the Margarita of described amount, succinum are pulverized, crossed after 100 mesh sieves, mix with basic zinc carbonate, grind, cross 160 mesh sieves, through comminution by gas stream to 200 order, obtain mixture a.
(2) mixture a mixes with 90-300 part liquid paraffin, adds pretreatment tank, is heated to 85 DEG C, be uniformly dispersed, while hot cross 120 mesh sieve sucking filtration to emulsion tank, surplus liquid paraffin in step (6) for disperseing trihydroxy stearin.
(3) microwax of getting described amount is broken into fritter, join successively pretreatment tank (as there being three mountain Yu essences in prescription with Flos Matricariae chamomillae fat (Chamomile butter), large tangerine fat (Angerine Butter), also add at this moment), fusing disperses completely, crosses while hot 120 mesh sieve sucking filtration to emulsion tank.
(4) step (2) being kept to temperature with step (3) gained mixture is 80-85 DEG C, and homogenizing (rotating speed 1200-1600rpm) more than 10min, is adjusted rotating speed to 700-800rpm continuation and stirred 15min.
(5) when the mixture that step (4) obtains is cooled to 65-70 DEG C, by described amount 11101 (oleogels) add wherein, the rotating speed homogenizing 5min of 1200-1600rpm, then stir with the rotating speed of 700-800rpm, cooling.
(6) when the mixture that step (5) obtains is cooled to 60 DEG C, add the trihydroxy stearin disperseing with remaining liq paraffin, homogenizing, stirs.
(7) mixture that step (6) obtains is cooled to 50 DEG C of VE, Herba bromi japonici core oil of adding successively described amount; As there being bisabolol in prescription, also add at this moment.
(8) mixture that step (7) obtains is cooled to 37-38 DEG C, and 700-800rpm stirs, and obtains hip pad cream product.
It is 100-500 part that liquid paraffin of the present invention amounts to consumption, adds at twice, adds liquid paraffin 90-300 part in step (2), surplus in step (6) for disperseing trihydroxy stearin.
Hip pad cream of the present invention is remarkable, safe and non-stimulating to the slight diaper dermatitis of infant (diaper rash) and purple grass oil effect, now relevant result of study is reported as follows:
One, safety and effect
1, method: adopt self cross-reference design.
At every turn greatly after an action of the bowels and take a shower time all dry with warm water cleaning, avoid moist diaper to continue chafe, note diligent changing babies' napkin.The water temperature of cleaning buttocks is suitable, prevents that water temperature over-high from increasing the weight of damage and the inflammatory reaction of skin.Clean to dry and dip in hip pad cream with cotton swab and be evenly applied to affected part afterwards, the scope of smearing is slightly larger than flushing area, and thickness is in 1mm left and right.Every day 1~2 time, use continuously 7 days.
2, number of cases
This clinical observation has been selected in altogether 30 examples and has met the experimenter of inclusion criteria, or is simple diaper rash, or is purple grass oil, or the two has concurrently, wherein 14 routine diaper rashs, 27 routine purple grass oils.Man's 16 examples, female's 14 examples, the maximum age is 13 months 12 days, minimum is 5 days, average 23.33 days January, course of disease average out to 4.7 days.
3, selected and exclusion standard
(1) diaper dermatitis (diaper rash) grade scale
The method that adopts " pediatrics and nursing " (Lu is encircleed license-master and compiled, 1986 publication times), is divided into slight and severe.Slight: to be confined to erubescence.Severe is divided 3 degree, heavy I degree: local skin flushing, has erythra; Heavy II degree: skin ulceration, decortication; Heavy III degree: the large stretch of erosion of local skin and abrasion, often with antibacterial or fungal infection.
(2) purple grass oil grade scale
Slight: anus is flushing around.Severe is divided 3 degree, heavy I degree: anus is red and swollen around; Heavy II degree: anus is red and swollen around, crissum occurs that single pus is swollen; Heavy III degree: anus is red and swollen around, and multiple abscess appear in crissum, with infection symptoms.
(3) inclusive criteria
2 years old with interior infant, male or female.Be diaper dermatitis or purple grass oil through clinical diagnosis, and be patients with mild, or skin of buttock is without abnormal but have frequent diarrhoea etc. other easily suffer from risk factors of diaper dermatitis or purple grass oil.Patient did not all use other drug or care product at selected first 2 weeks in not.Hip pad cream can be used as requested and the person of following up a case by regular visits to can be coordinated.
(4) exclusion standard: allergic constitution person.
Diaper parcel district and adjacent regions are associated with other skin symptom persons, and as infantile eczema, miliaria etc., easily impact is to result of the test judgement person.
4, observation item and the time
(1) general data
The situations such as inquiry baby's monthly age, sex, the course of disease (time-histories of diaper dermatitis, purple grass oil has occurred), merging protopathy, and be recorded in observation table.
(2) safety is observed
Observe the safety conditions that hip pad cream of the present invention uses in infant, observe and smear 15min, 30min after this product at every turn, 1h, 2h have no adverse reaction, and untoward reaction is graded, analysis result is recorded in observation table.
In the versions in 2007 " cosmetics health specification " that skin adverse reaction classification is issued according to Ministry of Public Health, the human body proof test skin adverse reaction grade scale of regulation judges:
0 grade of dermoanergy;
There is faint erythema in 1 grade of skin;
There is erythema, infiltration and pimple in 2 grades of skins;
There is erythema, edema, pimple and vesicle in 3 grades of skins;
There is erythema, edema and bulla in 4 grades of skins.
(3) effect is observed
Visual observations when each experimenter shower before use and at every turn by same research worker, observe whether new diaper dermatitis (diaper rash), purple grass oil occur, the experimenter of existing slight diaper dermatitis (diaper rash), purple grass oil is observed to local skin lesion and improve situation.
5, effect and safety evaluatio standard
By researcher, functional observation table and effect evaluation hurdle are evaluated and filled in to skin lesion situation, when statistical analysis, conclude, effect is divided into three grades of " disappearance ", " being clearly better ", " without being clearly better ".
6, result of study
(1) diaper dermatitis (diaper rash) effect
Treatment finishes experimenter's skin lesion and improves effect employing FAS population analysis, and less than 7 days persons lapsed to according to 7 days, in table 1, table 2.
Table 1 treatment finishes diaper dermatitis (diaper rash) skin lesion and improves effect (N=14)
Table 2 diaper dermatitis (diaper rash) disappears and adds up number of cases one time variation (N=14)
? The 1st day The 2nd day The 3rd day The 4th day The 5th day The 6th day The 7th day
Disappearance number of cases 0 0 0 2 5 8 11
Disappearance rate 0 0 0 14.3% 35.7% 57.1% 78.6%
(2) purple grass oil effect
Treatment finishes experimenter's skin lesion and improves effect employing FAS population analysis, and less than 7 days persons lapsed to according to 7 days, in table 3, table 4.
Table 3 treatment finishes purple grass oil skin lesion and improves effect (N=27)
Table 4 purple grass oil disappears and adds up number of cases one time variation (N=27)
? The 1st day The 2nd day The 3rd day The 4th day The 5th day The 6th day The 7th day
Disappearance number of cases 0 0 8 14 17 20 23
Disappearance rate 0 0 29.6% 51.9% 63.0% 74.1% 85.2%
Viewing duration, if use 7 days skin lesion disappearance persons of product natural law less than, the product of stopping using, has no diaper dermatitis (diaper rash) or purple grass oil recurrence when the observation period finished to 7 day.There is not new skin lesion in all experimenters.
(3) safety results
In 30 routine experimenters, there is untoward reaction in 1 example only, and time of origin is that while within the 3rd day, using after product 15 minutes, it shows as left side skin of buttock and occurs faint erythema, but medication disappears after half an hour, and researcher is thought may be irrelevant with individual body constitution difference.According to untoward reaction grade scale, it is 1 grade of untoward reaction.
Result of the test indicates, hip pad cream of the present invention can promote the healing of slight diaper dermatitis (diaper rash) and purple grass oil, and the slight diaper dermatitis of infant (diaper rash) and purple grass oil are all had to certain effect, and safety is better.
Two, repeatedly irritation test of rabbit
1, material and animal subject
Tested material: hip pad cream described in the arbitrary embodiment of the present invention.
Animal subject: 4 of regular grade rabbit, male and female half and half, body weight: 1.86-1.94kg.Provided by laboratory animal research center, Hubei Province, experimental animal production licence number is SCXK (Hubei Province) 2008-0005, the experimental animal certification of fitness number: NO.00020904.Give the front Health survey of given the test agent 3 days, Pass Test requirement.
2, test method
(1) dosage and grouping: hip pad cream group and matched group are established in test, contrast does not deal with, and adopts consubstantiality left and right sides self-contrast method, totally 4 rabbit.Hip pad cream group administered dose: 0.5g/ rabbit.
(2) preparation before test the selecting and test of rabbit: before test, 24h carries out cropping to family's rabbit back spinal column both sides battery powered shaver, the left and right each 3cm × 3cm of unhairing scope.Before giving again given the test agent, carefully check that skin of unhairing, whether because of unhairing damaged, has the skin of damage to test.
(3) tested rabbit is fixed, get that 0.5g hip pad cream is applied on the plucked skin in a rabbit back right side, application area is 2.5cm × 2.5cm, smear every day once, smear continuously 14 days; Before smearing, answer cropping at every turn.Depilation district, left side does not process and makes own control.
(4) experimental observation index: since second day, remove residual given the test agent with warm water, observed result after 1 hour, by the scoring of " cosmetics health specification " (version in 2007) skin irritation reaction standards of grading.
4 results:
Through observing, animal is without whole body poisoning manifestations, and the local skin that tested material is smeared, without the performance such as erythema and edema, the results are shown in Table 5.
Table 5 hip pad cream is to repeatedly irritation test result of rabbit
Result of the test shows: hip pad cream provided by the invention to rabbit repeatedly skin irritation be non-stimulated.
The above embodiment is only the preferred embodiment for absolutely proving that the present invention lifts, and protection scope of the present invention is not limited to this.What those skilled in the art did on basis of the present invention is equal to alternative or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.

Claims (7)

1. a hip pad cream, is characterized in that, effective ingredient comprises Margarita, succinum, VE, Herba bromi japonici core oil, Flos Matricariae chamomillae fat, large tangerine fat and basic zinc carbonate.
2. hip pad cream according to claim 1, is characterized in that, the parts by weight of each effective ingredient are as follows:
3. hip pad cream according to claim 1 and 2, is characterized in that, also comprises emulsifiable paste matrix, thickening agent and stabilizing agent.
4. hip pad cream according to claim 2, is characterized in that, also comprises the composition of following parts by weight:
5. hip pad cream according to claim 4, is characterized in that, also comprises the composition of following parts by weight:
Three mountain Yu essence 10-40;
Bisabolol 1-10.
6. the preparation method of hip pad cream claimed in claim 4, is characterized in that, step is as follows:
(1) respectively Margarita and succinum are pulverized, excessively after 100 mesh sieves, mix with basic zinc carbonate, grind, cross 160 mesh sieves, comminution by gas stream to 200 order, obtains mixture a;
(2) mixture a mixes with 90-300 part liquid paraffin, is heated to 80-85 DEG C, is uniformly dispersed, and crosses while hot 120 mesh sieves, and sucking filtration is to emulsion tank;
(3) after microwax fragmentation, add successively in pretreatment tank with Flos Matricariae chamomillae fat and large tangerine fat, fusing disperses completely, crosses while hot 120 mesh sieves, sucking filtration is to emulsion tank step (2) Suo Shu, and maintenance temperature is 80-85 DEG C, more than homogenizing 10min, stir 15-20min, obtain mixture b;
(4) mixture b is cooled to 65-70 DEG C, and oleogel is added wherein, and homogenizing 5-10min, stirs, and while being cooled to 60-65 DEG C, adds the trihydroxy stearin disperseing with remaining liq paraffin, homogenizing, and mixture c stirs to obtain;
(5) mixture c is cooled to 50 DEG C, adds successively VE, Herba bromi japonici core oil, stirs, and obtains hip pad cream product.
7. the preparation method of hip pad cream claimed in claim 5, is characterized in that, step is as follows:
(1) respectively Margarita and succinum are pulverized, excessively after 100 mesh sieves, mix with basic zinc carbonate, grind, cross 160 mesh sieves, comminution by gas stream to 200 order, obtains mixture a;
(2) mixture a mixes with 90-300 part liquid paraffin, is heated to 80-85 DEG C, is uniformly dispersed, and crosses while hot 120 mesh sieves, and sucking filtration is to emulsion tank;
(3) after microwax fragmentation, add successively in pretreatment tank with Flos Matricariae chamomillae fat, large tangerine fat and three mountain Yu essences, fusing disperses completely, crosses while hot 120 mesh sieves, and sucking filtration, to emulsion tank step (2) Suo Shu, obtains mixtures II;
(4) mixtures II maintenance temperature is 80-85 DEG C, more than homogenizing 10min, stir 15-20min, be cooled to 65-70 DEG C, oleogel is added wherein, homogenizing 5-10min, stirs, while being cooled to 60-65 DEG C, add the trihydroxy stearin disperseing with remaining liq paraffin, homogenizing, stirs, and obtains mixtures III;
(5) mixture I II is cooled to 50 DEG C, adds successively VE, Herba bromi japonici core oil, continues to be cooled to after 40 DEG C, then adds bisabolol, is uniformly mixed, and obtains hip pad cream product.
CN201410403991.8A 2014-08-15 2014-08-15 Hip cream and preparation method thereof Pending CN104146939A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410403991.8A CN104146939A (en) 2014-08-15 2014-08-15 Hip cream and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410403991.8A CN104146939A (en) 2014-08-15 2014-08-15 Hip cream and preparation method thereof

Publications (1)

Publication Number Publication Date
CN104146939A true CN104146939A (en) 2014-11-19

Family

ID=51872711

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410403991.8A Pending CN104146939A (en) 2014-08-15 2014-08-15 Hip cream and preparation method thereof

Country Status (1)

Country Link
CN (1) CN104146939A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748352A (en) * 2016-03-05 2016-07-13 广州丹奇日用化工厂有限公司 Skincare makeup removing cream and preparation method thereof
CN115282168A (en) * 2022-08-30 2022-11-04 马应龙大健康有限公司 Soothing moisturizer for relieving infantile eczema symptom and preparation method and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119107A1 (en) * 2000-12-18 2002-08-29 James Varani Method for protecting and restoring skin using selective MMP inhibitors
CN103027871A (en) * 2011-10-09 2013-04-10 陈金洲 Hip protecting cream for infants
CN103385834A (en) * 2013-08-02 2013-11-13 太仓市伟基生物科技有限公司 Preparation method of baby diaper rash cream

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119107A1 (en) * 2000-12-18 2002-08-29 James Varani Method for protecting and restoring skin using selective MMP inhibitors
CN103027871A (en) * 2011-10-09 2013-04-10 陈金洲 Hip protecting cream for infants
CN103385834A (en) * 2013-08-02 2013-11-13 太仓市伟基生物科技有限公司 Preparation method of baby diaper rash cream

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
小精灵儿童网站: "马应龙婴儿护臀膏保护孩子受损肌肤 ", 《HTTP://NEW.060S.COM/ARTICLE/2012/10/15/629928.HTM》, 15 October 2012 (2012-10-15), pages 1 - 2 *
小精灵儿童网站: "马应龙婴儿护臀膏保护孩子受损肌肤", 《HTTP://NEW.060S.COM/ARTICLE/2012/10/15/629928.HTM》 *
战晓凤 等: "中药护臀液治疗新生儿红臀", 《中国康复》 *
范胤璞: "强生婴儿护臀霜的巧用", 《护理研究》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105748352A (en) * 2016-03-05 2016-07-13 广州丹奇日用化工厂有限公司 Skincare makeup removing cream and preparation method thereof
CN115282168A (en) * 2022-08-30 2022-11-04 马应龙大健康有限公司 Soothing moisturizer for relieving infantile eczema symptom and preparation method and application thereof

Similar Documents

Publication Publication Date Title
CN109044915B (en) Infant hip-protecting cream and preparation process thereof
CN106361599A (en) Multi-vegetable-oil-containing infantile eczema care cream
WO2008140200A1 (en) External compositions for the skin
CN105168090A (en) Gromwell ointment and preparation method thereof
CN105769654A (en) Anti-sensitivity skin-care composition and application thereof to cosmetics
CN102406576A (en) Prinsepia utilis Royle oil-containing functional skin care product and preparation method thereof
US20060083708A1 (en) Composition using mineral salts for cosmetic or therapeutic treatment
CN107007513A (en) Topical composition and skin cleaning mask with dispel blackhead and pore refining effect
CN105902418A (en) Imitated sebum matrix, external preparation including imitated sebum matrix and application thereof
CN110638727B (en) Infant hip-protecting composition and preparation method and application thereof
CN104812398A (en) Topical compositions and methods of use
CN106266384A (en) A kind of plant ointment preventing and treating infant diaper rash and preparation method thereof
US20030185915A1 (en) Synergetic composition for the treatment of psoriasis and other skin disorders and method therefor
CN105327079A (en) Composition with repairing effect on mosquito bite and application thereof
Amer et al. Neonatal skin care: what should we do? A four‐week follow‐up randomized controlled trial at Zagazig University Hospitals
CN102697857B (en) Maternal towel liquid medicament for preventing puerperal infection and preparation method thereof
EP2124868A1 (en) Management of dermatitic symptoms of mammalian integument with emollient disinfectant formulations
KR20040107854A (en) Blending formulation of essential oils for holistic aromatherapy
CN104146939A (en) Hip cream and preparation method thereof
CN106821937A (en) Plant nanometer milk bath liquid
CN106214589A (en) Salubrious itching-relieving shower dew and preparation method thereof
CN101332302A (en) Formula for preparing anti-eczema and cutitis products and preparation method thereof
KR100852864B1 (en) Cosmetic composition containing extracts of perna canaliculus
Yagil Cosmeceuticals: Camel and Other Milk–Natural Skin Maintenance
CN106880698A (en) A kind of plants essential oil and preparation method for treating child's property vaginitis

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20141119