CN106138215A - A kind of medicine for treating eczema - Google Patents

A kind of medicine for treating eczema Download PDF

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Publication number
CN106138215A
CN106138215A CN201610689521.1A CN201610689521A CN106138215A CN 106138215 A CN106138215 A CN 106138215A CN 201610689521 A CN201610689521 A CN 201610689521A CN 106138215 A CN106138215 A CN 106138215A
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leaf
parts
eczema
red sage
sage root
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CN201610689521.1A
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Chinese (zh)
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赵月
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Individual
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of medicine for treating eczema, belong to field of medicaments, said composition contains following components in parts by weight: 18 22 parts of limacia sagittata leaf, 9 11 parts of red sage root leaf, sweet potato leaves 79 parts, vitamin C 0.5 1.0 parts, the invention also discloses the preparation method of a kind of aforementioned pharmaceutical compositions, the pharmaceutical composition of the present invention is used for treating eczema, especially infantile eczema, its excitant is little, side effect is little, effect is notable, short treating period, it is difficult to recurrence, additionally, the wide material sources of raw material, cost of material is low, preparation method is simple, make drug cost low, easily promote the use of.

Description

A kind of medicine for treating eczema
The application is Chinese patent: application number 2015102204775；Denomination of invention: a kind of drug regimen for eczema Thing and preparation method thereof；The divisional application of the applying date: 2015.05.05.
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of pharmaceutical composition for eczema and preparation method thereof.
Background technology
Eczema is a kind of scytitis reaction of the acute pruritus being caused by multiple internal and external factors.Divide acute, subacute, slow Three phases of property.Acute stage tool oozes out tendency, and chronic phase then infiltrates, plump.Some patients directly translate into chronic eczema.Skin damages to be had The features such as polymorphy, symmetry, itch and easy recurrent exerbation.Eczematosis, because of complexity, is often internal and external reasons interaction result.Internal cause Such as chronic digestive system disease, stress, insomnia, fatigue, emotional change, endocrinopathy, infection, metabolism barrier Hindering, external cause such as living environment, climate change, food etc. all can affect the generation of eczema.Environmental stimuli such as daylight, cold, dry Dry, hot, hot water is scalded and various animal skin, plant, cosmetics, soap, staple fibre etc. all can induce.It is complicated A kind of delayed allergy that the inside and outside factor causes.
According to existing statistics, there are about 20% even higher children's and about 15% adult can suffer from eczema, be one Plant common skin disease.
For the treatment of eczema, general at present external application calamine lotion or Groomwell root oil, also there is selection antihistamine antipruritic, Universal eczema is orally available or injects glucocorticoid, these therapeutic modalities often less effective, easily recurs, and medicine for oral administration Side effect is also relatively big, is not particularly suitable for the treatment of infantile eczema.
Content of the invention
The goal of the invention of the present invention is the problem for above-mentioned existence, provides a kind of determined curative effect, safety, side effect little For treating the pharmaceutical composition of eczema.
The technical solution used in the present invention is such that a kind of pharmaceutical composition for eczema, containing following weight parts Component:
Limacia sagittata leaf 18-22 part
Red sage root leaf 9-11 part
Sweet potato leaves 7-9 part
Vitamin C 0.5-1.0 part.
Limacia sagittata (Tinospora sagittata(Oliv.) Gagnep.), it is the evergreen of a kind of Menispermaceae limacia sagittata section Being wound around liana, being usually at present and be used as medicine limacia sagittata block root, have another name called " tinosporae ", its block root has clearing heat and detoxicating work( Effect.And its aerial part, especially its leaf, have no its report applied at present, typically all withered with season.
Labiate red sage root Salvia miltiorrhiza Bge., typically medicinal at present its is dried root and rhizome, its Root and rhizome have promoting blood circulation, inducing meastruation to relieve menalgia, and clear away heart-fire relieving restlessness, and cool blood disappears effect of carbuncle, and its aerial part especially leaf, mesh Before have been reported that and be made into health protection tea.
Ipomoea batatas (Ipomoea batatas (L.) Lam.) is a kind of common food, has anticancer, cardioprotection, prevention The effects such as pulmonary emphysema, diabetes, fat-reducing.It is commonly called as again pachyrhizus, sweet potato.Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica is remembered to be had " sweet potato qi-restoratives, strong Spleen whets the appetite, strong kidney yin ", and say the longevity of marine people's food.Its aerial part especially leaf, in rural area usually as livestock Food, its tender leaf point also frequently as vegetables eat.
Above-mentioned three kinds of leaves, typically no are at present applied or range of application is narrow, more have no and use it for treatment Eczema, and present inventor is applied by a large amount of clinical testings, uses above-mentioned three kinds of leaves, and it is aided with vitamin C, and adopt By suitable ratio, using it for treating eczema, especially infantile eczema, its excitant is little, and side effect is little, and effect is notable, treats Journey is short, is difficult to recurrence.
As preferred technical scheme, possibly together with the honey of 1-2 weight portion.Add appropriate honey, effect can be made more Good, it is preferred to use sophorae honey.
As preferred technical scheme, described limacia sagittata leaf is fresh leaf.
Present inventor is proved by lot of experiments, fresh limacia sagittata leaf, the active ingredient wherein containing More more rich, the effect for the treatment of eczema is more preferable relative to using cured leaf.
As preferred technical scheme, described red sage root leaf is fresh leaf.
Present inventor is proved by lot of experiments, and fresh red sage root leaf, the active ingredient wherein containing is more How more rich, the effect for the treatment of eczema is more preferable relative to using cured leaf.
As preferred technical scheme, described sweet potato leaves is fresh leaf.
Present inventor is proved by lot of experiments, fresh sweet potato leaves, and the active ingredient wherein containing is more How more rich, the effect for the treatment of eczema is more preferable relative to using cured leaf.
The above-mentioned pharmaceutical composition for eczema, its preparation method comprises the following steps:
(1) pulverize: by limacia sagittata leaf, red sage root leaf, sweet potato leaves is pulverized after weighing respectively；
(2) soak: the limacia sagittata leaf after pulverizing and red sage root leaf put into immersion 2-5 hour in vinegar, and maintain the temperature at 20-30 ℃；
(3) extract: by step (2) soak after limacia sagittata leaf and red sage root leaf together with soak, mix with sweet potato leaves, then The alcohol liquid using mass percentage concentration to be 10%-20% in percolate pot carries out seepage pressure effects, obtains extract；
(4) concentrate: the extract of step (3) gained is concentrated, obtains medicinal extract, then mix with vitamin C, i.e. ?.
Wherein, in step (1), the method for pulverizing can use pulverizer or the method smashed to pieces, in step (2), uses Vinegar soaks, and one of them purpose is to make the alkaline matter in limacia sagittata leaf and red sage root leaf leach, simultaneously in suitable temperature Under degree, some composition therein hydrolyzes in acid condition, and concurrent biochemical reaction generates new chemical composition；Step (3) In, use the alcohol of suitable concentration to carry out diacolation, extract wherein for the treatment effective composition of eczema.
As preferred technical scheme, in step (2), the weight of the vinegar being added is limacia sagittata leaf and red sage root leaf gross weight 2-3 times of amount.
As further preferred technical scheme, described vinegar is Shanxi mature vinegar.
Above-mentioned medicinal extract and vitamin C, the mixture of honey can be made oral formulations such as particle, capsule etc., or Making external preparation such as paste etc., when being used for treating infantile eczema, external application, adult's eczema can be taken orally with external application simultaneously Carry out.
In sum, owing to have employed technique scheme, the invention has the beneficial effects as follows: be used for treating eczema, especially Being infantile eczema, its excitant is little, and side effect is little, and effect is notable, short treating period, is difficult to recurrence, in addition, the wide material sources of raw material, Cost of material is low, and preparation method is simple so that drug cost is low, easily promotes the use of.
Detailed description of the invention
The present invention is described in detail below.
In order to make the purpose of the present invention, technical scheme and advantage clearer, following example, the present invention is carried out Further describe.It should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not used to limit The present invention.
Embodiment 1:
A kind of pharmaceutical composition for eczema, containing following components in parts by weight:
20 parts of fresh limacia sagittata leaf
10 parts of fresh salvia miltiorrhiza leaf
Fresh sweet potato leaves 8 parts
Vitamin C 0.8 part
Preparation method is, comprises the following steps:
(1) pulverize: by limacia sagittata leaf, red sage root leaf, sweet potato leaves is pulverized after weighing respectively；
(2) soak: the limacia sagittata leaf after pulverizing is put in vinegar with red sage root leaf and soaked 5 hours, and maintains the temperature at 28 DEG C, its The addition weight of middle vinegar is 3 times of limacia sagittata leaf and red sage root leaf；
(3) extract: by step (2) soak after limacia sagittata leaf and red sage root leaf together with soak, mix with sweet potato leaves, then The alcohol liquid using mass percentage concentration to be 20% in percolate pot carries out seepage pressure effects, obtains extract；
(4) concentrate: the extract of step (3) gained is concentrated, obtains medicinal extract, then mix with vitamin C, then It is separately added into pharmaceutic adjuvant, be respectively prepared paste A and granule A.
Embodiment 2
A kind of pharmaceutical composition for eczema, containing following components in parts by weight:
20 parts of fresh limacia sagittata leaf
10 parts of fresh salvia miltiorrhiza leaf
Fresh sweet potato leaves 8 parts
Vitamin C 0.8 part
Honey 1.2 parts
Preparation method is, comprises the following steps:
(1) pulverize: by limacia sagittata leaf, red sage root leaf, sweet potato leaves is pulverized after weighing respectively；
(2) soak: the limacia sagittata leaf after pulverizing is put in vinegar with red sage root leaf and soaked 5 hours, and maintains the temperature at 28 DEG C, its The addition weight of middle vinegar is 3 times of limacia sagittata leaf and red sage root leaf；
(3) extract: by step (2) soak after limacia sagittata leaf and red sage root leaf together with soak, mix with sweet potato leaves, then The alcohol liquid using mass percentage concentration to be 20% in percolate pot carries out seepage pressure effects, obtains extract；
(4) concentrate: the extract of step (3) gained is concentrated, obtains medicinal extract, then mix all with vitamin C and honey Even, it is then respectively adding pharmaceutic adjuvant, be respectively prepared paste B and granule B.
Embodiment 3
Clinical testing
1. subjects: randomly select 180 eczema patients at certain Hospital of Skin Diseases, the age between 18-25 year, average age 22 years old, the course of disease was between 1-6 month；
2. test packet: 180 patients are randomly divided into three groups, often organizes 60, respectively A group, B group and control group；
3. test method: the paste A using embodiment 1 to prepare to A group patient treats, and every day smears affected part 3-5 time；To B The paste B that group patient uses embodiment 2 to prepare treats, and every day smears affected part 3-5 time；Use the stove of routine to C group patient Sweet granite-wash agent according to circumstances oral antihistamines thing or glucocorticoid；The course for the treatment of is 2-3 week
4. the standard of curative effect evaluation:
Cure in the recent period: skin damages and recovers normal, does not itches, or has slight gargalesthesia.
Effective: 70% skin damages and recovers normal, and remaining skin damages and gradually takes a turn for the better, with slight itch.
Take a turn for the better: 30% skin damages and recovers normal, and remaining skin damages has plumpness or few liquid to ooze out, and with scratchiness, but still can stand.
Invalid: locally skin damages less than improvement standard, or without improving, even deteriorate.
5. result of the test, is shown in Table 1
Table 1 clinical test results table
As can be seen from the above table, use the medicine of the embodiment of the present invention to carry out eczema treatment, total effective rate more than 95%, and one Year, recurrence rate was only 1.8%, and compared with existing conventional treatment drug, total effective rate is high by more than 10%, and recurrence rate is greatly reduced.
Embodiment 4
Model case
Case 1: patient A, man, 23 years old, suffer from eczema 2 years, skin has the red millet appearance fash of sheet all over the body, and arm fash is oozed Going out, moderate is rotten to the corn, takes the granule B of embodiment 2, and smears paste B, every day 3-5 time, is clearly better after one week, continues After one week treatment is effective, fully recovers, follow up a case by regular visits to 1 year not recur after being further continued for treating two weeks.
Case 2: patient B, female, 19 years old, suffer from eczema 1.5 years, it is red and swollen that waist machine skin of abdomen needs shape, and disease sites has pain to itch Sense, pachyderma, there is a small amount of liquid to ooze out, take the granule B of embodiment 2, and smear paste B, every day 3-5 time, after one week Being clearly better, continual cure is effective after one week, is further continued for after one week treatment recovery from illness, follows up a case by regular visits to 1 year not recur.

Claims (1)

1. the pharmaceutical composition for eczema, it is characterised in that be made up of following components in parts by weight:
20 parts of fresh limacia sagittata leaf
10 parts of fresh salvia miltiorrhiza leaf
Fresh sweet potato leaves 8 parts
Vitamin C 0.8 part
Honey 1.2 parts.
CN201610689521.1A 2015-05-05 2015-05-05 A kind of medicine for treating eczema Pending CN106138215A (en)

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CN201510220477.5A CN104758358A (en) 2015-05-05 2015-05-05 Medicine composite used for eczema and preparation method thereof

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CN105012532A (en) * 2015-08-21 2015-11-04 赵月 Fat-decreasing and beautifying health-care product and preparation method thereof
CN105012203B (en) * 2015-08-21 2017-07-28 汕头市雅蒂化妆品有限公司 Face cream made from a kind of acne-removing composition and use said composition

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CN103251921A (en) * 2013-06-04 2013-08-21 云南施普瑞生物工程有限公司 Pharmaceutical composition for treating deficiency of both yin and yang, and preparation method, preparation and application thereof
KR20150026579A (en) * 2013-09-03 2015-03-11 (주) 와이디생명과학 Pharmaceutical Composition and heath care food comprising the extract of complex herb an active ingredient for preventing and treating allergic or non-allergic skin disease

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