CN103830482A - Traditional Chinese medicine preparation for treating stroke and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating stroke and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating stroke and a preparation method of the preparation, which belong to the field of traditional Chinese medicines. The traditional Chinese medicine preparation is prepared from the following raw materials as effective components: aconitum kusnezoffii, alhagi sparsifolia sugar grain, cynanchum thesioides, chufa, roughhaired holly root, calcined oyster shell, mahonia bealei carr, arrowhead, hawksbill, clematis filamentosa, herb of shiny cinquefoil, michelia figo, cassia sophera, cortex albiziae, basil and cannabis sativa. The traditional Chinese medicine preparation disclosed by the invention is reasonable in matching of selected medicine materials, meets the pharmaceutical science of traditional Chinese medicines and theories of modern medicine and pharmacology, has the functions of calming the nerve, inducing resuscitation, dispelling melancholy, restoring consciousness, dispelling wind, smoothening qi, calming down the heart and removing carbuncle, has a remarkable curative effect on symptoms of hemiplegia, facial paralysis, unconsciousness remaining, disordered consciousness, delirious speech, madness and the like caused by stroke, is short in treatment course, rapid to take the effect and free of toxic or side effect, can alleviate the symptom of nervous centralis cell damage caused by cerebral ischemia of a patient, can relieve the patient with stroke from illness, is safe, reliable and low in cost, and is worthy of clinical popularization and application since the disease does not relapse after being healed.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to a kind of Chinese medicine preparation and preparation method for the treatment of apoplexy.
Background technology
Apoplexy is the cerebral tissue death because cerebral blood flow reduces or cerebral oxygen supply deficiency causes.Apoplexy is divided into ischemic or hemorrhagic, in cerebral infarction, interrupts because arteriosclerosis or thrombus obstruction blood vessel make the blood supply of brain, breaks at hemorrhagic apoplexy medium vessels, and normal blood flow interrupts, and blood infiltrates brain and also destroys cerebral tissue.
When cerebral infarction, angiemphraxis can occur in any tremulous pulse of brain.The deposition of for example lipid can occur in carotid artery, thereby make blood flow attenuate like current by a pipeline that has an obstacle, this situation is quite serious, because every bilateral common carotid artery provides most brain blood supply conventionally, lipid also can come off from carotid wall, with blood flow, blocking-up small artery, finally makes it total blockage; Carotid artery, vertebral artery and branch thereof can cause infraction by other reasons.For example come off at the thrombosis of heart and cardiac valve formation, cause embolic apoplexy with artery blood flow to its result of brain, the apoplexy of this type is most commonly in recently to be accepted cardiac operation, has cardiac valve lesion and ARR patient, fat embolism is the rare reason of apoplexy, if enter blood flow and finally merge at intra-arterial from the fat of fracture site bone marrow, can form many emboluses; Cerebral vessels is because of inflammation or the narrow apoplexy that also can cause of infection, thereby the medicine such as cocaine and amfetamine also can make angiostenosis cause apoplexy, blood pressure declines and often seriously reduces cerebral blood flow suddenly, cause fainting, if hypotension is serious and sustainable existence also can cause apoplexy, this situation can betide wound and the perform the operation massive blood loss, myocardial infarction or the arrhythmia that cause.
Apoplexy is to affect one of disease that developed country's medical expense is the most expensive.Because the Direct Nursing expense of acute treatment and rehabilitation accepted is very expensive, and impact income being caused due to DB, make the medical expense of apoplexy disease quite high.In addition, at several years of future, because population is tending towards aging, developing country was tending towards " west ", and the risk factor that apoplexy is accompanied constantly increase, and therefore estimated that the burden that apoplexy causes will constantly increase.
The medicine of some treatment apoplexy is applied very extensively in the world at present, not equal to but be to be more appropriate as prophylactic agent as medicine, because the acute stage of apoplexy, is used this class effect of drugs unsatisfactory.Therefore, can not produce the medicine of any toxic and side effects, become one of problem of various big hospital research.
Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of apoplexy, the selected medical material compatibility of Chinese medicine preparation of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and have to calm the nerves and have one's ideas straightened out, resolving depression refreshment, dispelling wind circulation of qi promoting, effect of mind calming eliminating carbuncle, the hemiplegia that apoplexy is caused, facial hemiparalysis, remain unconscious, conciousness disorder, the delirium symptom such as go mad has significant therapeutic effect, short treating period, instant effect, without any side effects, can alleviate the axoneure damage symptom due to patient's cerebral ischemia, make the patients with cerebral apoplexy misery that throws off one's illness, non-relapse after healing, safe and reliable, with low cost, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for apoplexy, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
15～40 parts of 18～42 portions of Corm Eleocharitiss of 18～42 parts of Herba Cynanchi Thesioidis of 18～42 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
14～38 parts of 14～38 parts of arrowheads of 14～38 parts of Fructus Mahoniaees of 14～38 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
8～28 parts of 8～28 parts of HANXIAOHUA of 11～34 parts of Herba potentillae fulgentis of 11～34 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
4～22 parts of 4～22 parts of Spica Cannabis Tener of 5～24 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 5～24 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
19～35 parts of 22～36 portions of Corm Eleocharitiss of 22～36 parts of Herba Cynanchi Thesioidis of 22～36 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
18～34 parts of 18～34 parts of arrowheads of 18～34 parts of Fructus Mahoniaees of 18～34 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
11～25 parts of 11～25 parts of HANXIAOHUA of 15～31 parts of Herba potentillae fulgentis of 15～31 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
7～19 parts of 7～19 parts of Spica Cannabis Tener of 8～21 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 8～21 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
23～31 parts of 26～32 portions of Corm Eleocharitiss of 26～32 parts of Herba Cynanchi Thesioidis of 26～32 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
22～30 parts of 22～30 parts of arrowheads of 22～30 parts of Fructus Mahoniaees of 22～30 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
14～22 parts of 14～22 parts of HANXIAOHUA of 19～27 parts of Herba potentillae fulgentis of 19～27 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
10～16 parts of 10～16 parts of Spica Cannabis Tener of 11～17 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 11～17 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
27 parts of 30 portions of Corm Eleocharitiss of 30 parts of Herba Cynanchi Thesioidis of 30 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
26 parts of 26 parts of arrowheads of 26 parts of Fructus Mahoniaees of 26 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
18 parts of 18 parts of HANXIAOHUA of 23 parts of Herba potentillae fulgentis of 23 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
13 parts of 13 parts of Spica Cannabis Tener of 14 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 14 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
Treat a preparation method for the Chinese medicine preparation of apoplexy, comprise following processing step:
(1) Radix Aconiti Kusnezoffii, Mel Alhagi, Herba Cynanchi Thesioidis, Fructus Mahoniae, arrowhead, HANXIAOHUA, Semen Cassiae Sopherae, Cortex Albiziae and Spica Cannabis Tener are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 DEG C, relative density is 1.10～1.13, for subsequent use;
(2) Corm Eleocharitis, Carapax Eretmochelydis and Herba Ocimi (Herba Ocimi Pilosi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Radix Ilicis Asprellae, Clematis filamentosa Dunn and Herba potentillae fulgentis are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 DEG C of simmer down tos, relative density is 1.12～1.16 is for subsequent use;
(4) Concha Ostreae (calcined) is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, juice and fine powder are mixed, make capsule, obtain the Chinese medicine preparation for the treatment of apoplexy of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Radix Aconiti Kusnezoffii: acrid in the mouth, hardship, hot in nature, poison greatly; GUIXIN, liver, spleen channel.Expelling wind and removing dampness, dispelling cold by warming the meridian, reducing swelling and alleviating pain.Cure mainly anemofrigid-damp arthralgia, arthralgia, wind syndrome of head headache, apoplectic dyscinesia, trusted subordinate's cold type of pain, colic of cold type is had a pain, traumatic injury, swelling and pain due to blood stasis, carbuncle of yin nature toxic swelling, narcotic analgesic.
Mel Alhagi: sweet in the mouth, acid, property is flat; GUIXIN, lung, spleen, small intestinal, kidney channel.Convergence astringing intestine to stop diarrhea, pain relieving.Cure mainly dysentery, diarrhoea, abdominal distention, hectic fever due to YIN-deficiency excessive thirst, headache, toothache.Supplement to the Herbal carries: " main bone heat, phlegmatic cough, the sudden and violent hematochezia of dysentery, appetizing, quenches the thirst, relieving restlessness.”
Herba Cynanchi Thesioidis: sweet in the mouth, cool in nature; Return lung meridian.Tonifying the lung gas, resolving heat and reducing pathogenic fire, promoting the production of body fluid to quench thirst, anti-inflammatory analgetic.Cure mainly hyperactivity of deficient fire, have sore throat, deficiency of both vital energy and Yin, Mental fatigue is forgetful, and fidgets due to deficiency is thirsty, dizzy insomnia, puerperal asthenia, hypogalactia.
Corm Eleocharitis: sweet in the mouth, cold in nature, nontoxic.Promoting the production of body fluid for nourishing the lung, the sharp intestinal that reduces phlegm, diuresis promoting, eliminating carbuncle removing toxic substances, removing heat from blood removing dampness, de-swelling helps digestion.Cure mainly calentura and quench one's thirst, jaundice, conjunctival congestion, laryngopharynx swelling and pain, urine is fervid deficient, affection due to external wind and heat, the diseases such as mass in the abdomen.Modern medicine study confirms, Corm Eleocharitis all has certain inhibitory action to staphylococcus aureus, escherichia coli and bacillus pyocyaneus, and the heat that can disappear removes expectorant, reduces blood pressure.
Radix Ilicis Asprellae: bitter in the mouth, sweet, cold in nature; Return lung, liver, large intestine channel.Clearing away heat and promoting production of body fluid, dissipating blood stasis removing toxic substances.Cure mainly flu, headache, dizzy, calentura excessive thirst, eruptive disease, diarrhea of heat type, lung abscess, pertussis, laryngopharynx swelling and pain, hemorrhoidal bleeding, gonorrhea, furuncle swelling toxin, traumatic injury." Nanning City's medicine will " carries: " heat-clearing and toxic substances removing, lung moistening is quenched the thirst.Soothe sore throat thirsty, hemoptysis, eruptive disease.”
Concha Ostreae (calcined): salty in the mouth, cold nature; Enter liver, kidney channel.Suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating.Cure mainly vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter ， WEIJIA mass in the abdomen.Compendium of Material Medica is carried: " resolving phlegm and softening hard masses, removing damp-heat, only heart temper pain, under dysentery, reddish and whitish turbid urine, the hernia that disappears abdominal mass is amassed piece, wart disease tuberculosis." modern medicine study confirmation, Concha Ostreae (calcined) has convergence, calmness, removing toxic substances, analgesic effect, and acidic extraction thing has inhibitory action to poliovirus.
Fructus Mahoniae: bitter in the mouth, cool in nature; Return spleen, kidney, urinary bladder channel.Clearind deficient heat, the kidney invigorating dampness.Cure mainly osteopyrexia and fever, soreness of the waist and knees, dizziness and tinnitus, damp-heat diarrhea, leukorrhagia, stranguria with turbid discharge." modern Practical Chinese medicinal " carries: " for Tuberculous hectic fever, hectic fever due to YIN-deficiency, soreness of waist and knee, the diseases such as dizziness, tinnitus.”
Arrowhead: sweet in the mouth, property are put down.The relieving constipation of invigorating blood circulation, clearing heat for detumescence, promoting the production of body fluid for nourishing the lung, invigorating the spleen and replenishing QI.Modern medicine study confirmation, arrowhead has unique curative effect to the disease such as impairment caused by overstrain, cough with asthma, and can have adjusting facilitation to human body flesh.Modern nutriology thinks that arrowhead is rich in vitamin and mineral potassium, calcium and dietary fiber, and protein is also more, can prevent anemia and edema etc., also can appetite stimulator.
Carapax Eretmochelydis: sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.Suppressing the hyperactive liver arresting convulsion, heat-clearing and toxic substances removing.Cure mainly the high heat of calentura, unconsciousness and delirium is twitched, and pediatric epilepsy scared is dizzy, vexed insomnia, carbuncle sore tumefacting virus." detailed outline " carries: " separate pox poison, relieving palpitation god, anxious frightened infantile convulsive seizure due to fright, typhoid fever accumulation of heat, raving.”
Clematis filamentosa Dunn: bitter in the mouth, slightly cool in nature; GUIXIN, Liver Channel.Sedation and analgesia, clearing away liver-fire, mind calming god, blood pressure lowering, removing obstruction in the collateral to relieve pain.Cure mainly hypertension, insomnia, headache, numb limbs and tense tendons, wind-heat of liver channel, conjunctival congestion and swelling pain, acute toothache, rheumatic arthralgia.Modern medicine study confirms, Clematis filamentosa Dunn is to improving the caused symptom of hypertension, as headache, giddy, feeling of fullness in the head, numb limbs and tense tendons, insomnia waits a good curative effect, and preliminary observation all has therapeutical effect to the hemiplegic patient that patients with coronary heart disease and cerebrovascular accident are caused simultaneously.
Herba potentillae fulgentis: bitter in the mouth, puckery, cold in nature; Return spleen, large intestine channel.Heat clearing and inflammation relieving, cooling blood for hemostasis.Cure mainly dysentery, enteritis, stomachache, hemoptysis of pulmonary tuberculosis, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, furuncle." choosing of Yunnan Chinese herbal medicine " carries: " cooling blood for hemostasis, astringing to arrest diarrhea.Control hemoptysis of pulmonary tuberculosis, spit blood, epistaxis, dyspepsia, anemia, dysentery.”
HANXIAOHUA: acrid in the mouth, hardship, warm in nature; Return Liver Channel; Removing pathogenic heat from blood and toxic substance from the body, the resolving depression of calming the nerves; Modern medicine study confirms, the HANXIAOHUA nervous nerve that can relax contributes to calm body and mind, removes anxiety, pacifies irritated emotion, and the balance of recovery body and mind, inspires enthusiasm, stimulate vitality, and allaying tiredness.
Semen Cassiae Sopherae: sweet in the mouth, hardship, property is flat, nontoxic; Return lung, stomach, large intestine channel.Liver heat removing and eyesight improving, during stomach invigorating is adjusted, intestine moistening removing toxic substances.Cure mainly conjunctival congestion and swelling pain, dizzy feeling of fullness in the head, oral erosion, habitual constipation, infantile malnutrition, dysentery, malaria.Supplement to the Herbal carries: " fire is processed and drunk extremely perfume, and expectorant is quenched the thirst, and makes us sitting up, in tune.”
Cortex Albiziae: sweet in the mouth, property is flat, nontoxic; GUIXIN, Liver Channel.Resolving stagnation for tranquilization, promoting blood circulation and detumescence, resolving depression and blood, mind calming eliminating carbuncle.Curing mainly irritability, melancholy insomnia, lung abscess skin ulcer swells, falls and flutter the diseases such as grieved." detailed outline " carries: " and blood, detumescence, pain relieving.”
Herba Ocimi (Herba Ocimi Pilosi): acrid in the mouth, sweet, warm in nature; Return lung, spleen, stomach, large intestine channel.Dispelling wind circulation of qi promoting, removing dampness helps digestion, invigorates blood circulation, removing toxic substances.Cure mainly headache due to invasion of exogenous pathogens, the flatulence due to improper diet stagnation of QI, gastralgia, has loose bowels, menoxenia, traumatic injury, snake bite and insect sting, skin eczema, urticaria pruritus.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " detumescence of dispeling the wind, eliminating stasis to stop pain.Control flatulence, dyspepsia, stomachache, enteritis, diarrhea, affection of exogenous wind-cold, headache, chest pain, traumatic injury congestive edema, rheumatic arthralgia, eczematous dermatitis.”
Spica Cannabis Tener: acrid in the mouth, property is flat, poisonous.Dispel the wind, pain relieving, spasmolytic.Cure mainly gout, arthromyodynia, demented, insomnia, cough with asthma." medicine figure examines " carries: " main anemia is dry coughs, and pacifies nerve, only twitch, and gout, arthromyodynia, sleeps peacefully, regulating menstruation removing blood stasis with potent drugs, uterus non-restoring, ovum adenalgia, demented, flirt, skin is itched.”
The present invention compared with prior art, has following beneficial effect:
1, the selected medical material compatibility of Chinese medicine preparation of the present invention is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and have calm the nerves have one's ideas straightened out, effect of resolving depression refreshment, dispelling wind circulation of qi promoting, mind calming eliminating carbuncle, hemiplegia, facial hemiparalysis that apoplexy is caused, remain unconscious, conciousness disorder, delirium are gone mad etc., and symptom has significant therapeutic effect, short treating period, instant effect, without any side effects.
2, Chinese medicine preparation of the present invention can alleviate the axoneure damage symptom due to patient's cerebral ischemia, makes the patients with cerebral apoplexy misery that throws off one's illness, and non-relapse after healing is safe and reliable, with low cost, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Aconiti Kusnezoffii 36g Mel Alhagi 36g Herba Cynanchi Thesioidis 36g Corm Eleocharitis 35g
Radix Ilicis Asprellae 34g Concha Ostreae (calcined) 34g Fructus Mahoniae 34g arrowhead 34g
Carapax Eretmochelydis 31g Clematis filamentosa Dunn 31g Herba potentillae fulgentis 25g HANXIAOHUA 25g
Semen Cassiae Sopherae 21g Cortex Albiziae 21g Herba Ocimi (Herba Ocimi Pilosi) 19g Spica Cannabis Tener 19g.
Treat a preparation method for the Chinese medicine preparation of apoplexy, comprise following processing step:
(1) Radix Aconiti Kusnezoffii, Mel Alhagi, Herba Cynanchi Thesioidis, Fructus Mahoniae, arrowhead, HANXIAOHUA, Semen Cassiae Sopherae, Cortex Albiziae and Spica Cannabis Tener are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 DEG C, relative density is 1.10～1.13, for subsequent use;
(2) Corm Eleocharitis, Carapax Eretmochelydis and Herba Ocimi (Herba Ocimi Pilosi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Radix Ilicis Asprellae, Clematis filamentosa Dunn and Herba potentillae fulgentis are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 DEG C of simmer down tos, relative density is 1.12～1.16 is for subsequent use;
(4) Concha Ostreae (calcined) is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, juice and fine powder are mixed, make capsule, obtain the Chinese medicine preparation for the treatment of apoplexy of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 3 (every 0.5g), warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, can fully recover 3～4 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Embodiment 2
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Aconiti Kusnezoffii 32g Mel Alhagi 32g Herba Cynanchi Thesioidis 32g Corm Eleocharitis 31g
Radix Ilicis Asprellae 30g Concha Ostreae (calcined) 30g Fructus Mahoniae 30g arrowhead 30g
Carapax Eretmochelydis 27g Clematis filamentosa Dunn 27g Herba potentillae fulgentis 22g HANXIAOHUA 22g
Semen Cassiae Sopherae 17g Cortex Albiziae 17g Herba Ocimi (Herba Ocimi Pilosi) 16g Spica Cannabis Tener 16g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 3
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Aconiti Kusnezoffii 30g Mel Alhagi 30g Herba Cynanchi Thesioidis 30g Corm Eleocharitis 27g
Radix Ilicis Asprellae 26g Concha Ostreae (calcined) 26g Fructus Mahoniae 26g arrowhead 26g
Carapax Eretmochelydis 23g Clematis filamentosa Dunn 23g Herba potentillae fulgentis 18g HANXIAOHUA 18g
Semen Cassiae Sopherae 14g Cortex Albiziae 14g Herba Ocimi (Herba Ocimi Pilosi) 13g Spica Cannabis Tener 13g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 4
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Aconiti Kusnezoffii 26g Mel Alhagi 26g Herba Cynanchi Thesioidis 26g Corm Eleocharitis 23g
Radix Ilicis Asprellae 22g Concha Ostreae (calcined) 22g Fructus Mahoniae 22g arrowhead 22g
Carapax Eretmochelydis 19g Clematis filamentosa Dunn 19g Herba potentillae fulgentis 14g HANXIAOHUA 14g
Semen Cassiae Sopherae 11g Cortex Albiziae 11g Herba Ocimi (Herba Ocimi Pilosi) 10g Spica Cannabis Tener 10g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Embodiment 5
Raw material composition and the weight of Chinese medicine preparation effective ingredient of the present invention are:
Radix Aconiti Kusnezoffii 22g Mel Alhagi 22g Herba Cynanchi Thesioidis 22g Corm Eleocharitis 19g
Radix Ilicis Asprellae 18g Concha Ostreae (calcined) 18g Fructus Mahoniae 18g arrowhead 18g
Carapax Eretmochelydis 15g Clematis filamentosa Dunn 15g Herba potentillae fulgentis 11g HANXIAOHUA 11g
Semen Cassiae Sopherae 8g Cortex Albiziae 8g Herba Ocimi (Herba Ocimi Pilosi) 7g Spica Cannabis Tener 7g.
Chinese medicine preparation preparation method processing step and the usage and dosage of the present embodiment are identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of apoplexy, select the routine clinical observation of patients with cerebral apoplexy 188 of making a definite diagnosis, patient is divided into two groups for the treatment of group and matched groups at random, treatment group 94 examples, wherein male's 48 examples, women's 46 examples, 3～67 years old age, 35 years old mean age, the course of disease 1～11 year; Matched group 94 examples, wherein male's 47 examples, women's 47 examples, 4～66 years old age, 35 years old mean age, the course of disease 1～10 year.
The course of disease, the degrees of symptoms for the treatment of group and two groups of cases of matched group are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group is taken Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 3 (every 0.5g), warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, can fully recover 3～4 courses for the treatment of, and the person of being in a bad way follows the doctor's advice and drinks the amount of adding.
Matched group is taken almitrine and raubasine sheet, oral, one time 1,2 times on the one, sooner or later clothes after the meal; 1 of maintenance dose one time, 1 time on the one, the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: transference cure, it is normal that health physical signs is recovered, and diet is normal, and body weight increases, and action is normal, and sign is improved completely, and patient is without any bad sensation, and mental status is good.
(2) effective: symptom takes a turn for the better to some extent, and health physical signs changes to some extent, and part index number is normal, and diet is normal, body weight increases, pronunciation and action normal, and sign major part makes moderate progress, and mental status takes a turn for the better.
(3) invalid: symptom is without improvement.
4, result:
| ? | Number of cases | Cure | Effectively | Invalid | Cure rate | Total effective rate |
| Treatment group | 94 | 67 | 24 | 3 | 71.3% | 96.8% |
| Matched group | 94 | 20 | 31 | 43 | 21.3% | 54.3% |
Above result demonstration, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is given an example:
1, Zheng, man, 6 years old, people from Tangshan.When patient, find that it affects brain blood supply wretched insufficiency, cause brain function ateliosis, cerebral blood flow is on the low side, motor system hypoevolutism, about eight or nine months, just can stand up, after 13 months, just slowly can sit, when two October, can creep, two years old time, can hold up station and hold up away, two upper limb muscular tension can not have, and two muscle tension of lower extremities are slightly high, two ankle shake contraction positives.Take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, symptom is clearly better, and takes after 3 courses for the treatment of of Chinese medicine preparation of the present invention, symptom disappears substantially, and it is normal that biochemical indicator recovers, and can own freely play, substantially freely, body weight and diet increase, with normal child of the same age indistinction in walking.
2, thank certain, female, 31 years old, people from Changzhi, Shanxi.Patient at ordinary times operating pressure is large, the overtime work of often staying up late, and also dinner party is a lot, and have a meal in the family of often accompanying a guest, plenty of meat and fish everyday, a delicious food is thick greasy, and tobacco and wine be can't do without especially, are even sometimes still drank after a night and do not disappear, and carry out again next dinner party.A morning of the first two months, after patient gets up, realize that suddenly talk oneself some is not fluent, corners of the mouth sialorrhea, hemianesthesia is unable, so remove in a hurry hospital therapy under layman's help.Through detailed inspection, doctor makes a definite diagnosis it for lacunar infarction, belong to smaller apoplexy, doctor advised is taken Chinese medicine preparation of the present invention, takes after 1 course for the treatment of, and above-mentioned symptom is clearly better, continue to take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, recovery from illness, physical recovery is normal, follows up a case by regular visits to without recurrence after 2 years.
3, Korea Spro, man, 47 years old, Yancheng, Jiangsu Province people.Patient's left foot, the right hand are numb, and general paralysis is unable, cannot stand voluntarily, needs other people to assist in, agraphia dialogue, and household gives its hospital admission, is diagnosed as apoplexy.Patient used several different methods treatment, have no improvement, to our hospital upon somebody's introduction, take after 1 course for the treatment of of Chinese medicine preparation of the present invention, biped, both hands or face fiber crops take a turn for the better to some extent, life is basic takes care of oneself, continue to take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, biped, both hands or face fiber crops recover completely, and life is taken care of oneself completely, normally shift, follows up a case by regular visits to after 1 year without recurrence.
4, Tang, female, 53 years old, people from Jinzhou, Liaoning.Certain day morning, family numbers of patients was found to make patient reactionless, be sent in a hurry nearby hospitals, patient lies in a comatose condition, the circle such as both sides isocoria, light reflex is poor, cervical region has opposing, right side Hoffmann sign (+), right side Ba Bin Ji Shi levies (+), do head CT inspection, in waiting head CT check result, give immediately injection treatment, after injection, in disease population, send sound, eye rotation, can speech, and can walk, but walking is unstable, memoryless, under family members' nurse, take Chinese medicine preparation of the present invention, take after 1 course for the treatment of, symptom takes a turn for the better to some extent, continue to take after 2 courses for the treatment of, symptom is clearly better, patient's freedom of movement, continue to take 1 course for the treatment of, recovery from illness, the recurrence of following up a case by regular visits to that so far there are no.
5, Feng, man, 62 years old, people from Jilin Baishan.No matter the ictal right side of patient limbs follow dysphonia 10 days, cerebral infarction, right limb activity ability, hypertension, brain blood supply wretched insufficiency, and endocrine confusion.Take Chinese medicine preparation of the present invention, take after 3 courses for the treatment of, cerebral infarction part disappears, and it is normal that biochemical indicator recovers, and substantially freely, body weight and diet increase in walking, and the right limb activity ability is normal.
6, Peng, female, 37 years old, people from Suqian, Jiangsu.How also patient the unexpected stroke of can do by myself, and the state of an illness is quite serious.Through the treatment of month, although she has recovered now part action and language function, in life or too busy to get away others treatment.Before one month, patient felt what head was a little swooned before this, and the work fatigue of thinking is not taken notice of very much yet.Within several days, get off, feel again to speak less agile, tongue seems not listen commander, occurs suddenly hemiplegia evening on the same day, can not talk, the apoplexy symptom of large minor illness incontinence.Household loses no time to send to hospital, is the apoplexy that cerebral infarction causes after diagnosing.Recommend to take after 2 courses for the treatment of of Chinese medicine preparation of the present invention through doctor, various functions is in slow recovery, but can't freely walk, bad when exchanging ability to express with people and being also fashion.Continue to take after 2 courses for the treatment of of Chinese medicine preparation of the present invention, state of an illness recovery from illness, can normally go to work, and after 2 years, follows up a case by regular visits to and has no recurrence.
Claims (5)
1. a Chinese medicine preparation for the treatment of apoplexy, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
15～40 parts of 18～42 portions of Corm Eleocharitiss of 18～42 parts of Herba Cynanchi Thesioidis of 18～42 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
14～38 parts of 14～38 parts of arrowheads of 14～38 parts of Fructus Mahoniaees of 14～38 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
8～28 parts of 8～28 parts of HANXIAOHUA of 11～34 parts of Herba potentillae fulgentis of 11～34 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
4～22 parts of 4～22 parts of Spica Cannabis Tener of 5～24 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 5～24 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
2. a kind of Chinese medicine preparation for the treatment of apoplexy according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
19～35 parts of 22～36 portions of Corm Eleocharitiss of 22～36 parts of Herba Cynanchi Thesioidis of 22～36 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
18～34 parts of 18～34 parts of arrowheads of 18～34 parts of Fructus Mahoniaees of 18～34 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
11～25 parts of 11～25 parts of HANXIAOHUA of 15～31 parts of Herba potentillae fulgentis of 15～31 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
7～19 parts of 7～19 parts of Spica Cannabis Tener of 8～21 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 8～21 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
3. a kind of Chinese medicine preparation for the treatment of apoplexy according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
23～31 parts of 26～32 portions of Corm Eleocharitiss of 26～32 parts of Herba Cynanchi Thesioidis of 26～32 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
22～30 parts of 22～30 parts of arrowheads of 22～30 parts of Fructus Mahoniaees of 22～30 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
14～22 parts of 14～22 parts of HANXIAOHUA of 19～27 parts of Herba potentillae fulgentis of 19～27 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
10～16 parts of 10～16 parts of Spica Cannabis Tener of 11～17 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 11～17 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
4. a kind of Chinese medicine preparation for the treatment of apoplexy according to claim 1, is characterized in that: raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
27 parts of 30 portions of Corm Eleocharitiss of 30 parts of Herba Cynanchi Thesioidis of 30 parts of Mel Alhagi of Radix Aconiti Kusnezoffii
26 parts of 26 parts of arrowheads of 26 parts of Fructus Mahoniaees of 26 parts of Concha Ostreae (calcined)s of Radix Ilicis Asprellae
18 parts of 18 parts of HANXIAOHUA of 23 parts of Herba potentillae fulgentis of 23 parts of Clematis filamentosa Dunn of Carapax Eretmochelydis
13 parts of 13 parts of Spica Cannabis Tener of 14 portions of Herba Ocimi (Herba Ocimi Pilosi)s of 14 portions of Cortex Albiziaes of Semen Cassiae Sopherae.
5. a preparation method for the treatment of the Chinese medicine preparation of apoplexy as described in claim 1～4 any one, is characterized in that: comprise following processing step:
(1) Radix Aconiti Kusnezoffii, Mel Alhagi, Herba Cynanchi Thesioidis, Fructus Mahoniae, arrowhead, HANXIAOHUA, Semen Cassiae Sopherae, Cortex Albiziae and Spica Cannabis Tener are cleaned, put into container, add the distilled water of 8～10 times of amounts, soak after 5～6 hours, boil 3～4 hours, extract; Again add 6～8 times of amount distilled water, boil 2～3 hours, extract; Finally, add 4～6 times of amount distilled water, heated and boiled 1～2 hour, extracts; Merge three times extracting solution, filter, obtain filtrate, be condensed into the thick paste that at 60 DEG C, relative density is 1.10～1.13, for subsequent use;
(2) Corm Eleocharitis, Carapax Eretmochelydis and Herba Ocimi (Herba Ocimi Pilosi) are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(3) Radix Ilicis Asprellae, Clematis filamentosa Dunn and Herba potentillae fulgentis are cleaned, immersed 80% the alcohol solution dipping 1～2 hour of 5 times of amounts, heating extraction 3 hours, reclaims ethanol, filters, and obtains filtrate, and the thick paste that at 65 DEG C of simmer down tos, relative density is 1.12～1.16 is for subsequent use;
(4) Concha Ostreae (calcined) is put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(5) above-mentioned steps (1)～(4) prepared thick paste, juice and fine powder are mixed, make capsule, obtain the Chinese medicine preparation for the treatment of apoplexy of the present invention.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104147161A (en) * | 2014-09-02 | 2014-11-19 | 王建国 | Medicine for treating stroke and preparation method thereof |
| CN107137669A (en) * | 2017-06-29 | 2017-09-08 | 河南中医药大学 | It is a kind of to treat Chinese medicine composition of cerebral apoplexy and preparation method thereof |
| KR101837444B1 (en) | 2016-10-25 | 2018-03-13 | 한국 한의학 연구원 | Composition for prevention, improvement or treatment of cognitive dysfunction comprising Potentilla fragarioides extract as effective component |
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| CN103550702A (en) * | 2013-11-07 | 2014-02-05 | 吴鑫 | Traditional Chinese medicine composition for cerebral arterial thrombosis |
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| CN103550702A (en) * | 2013-11-07 | 2014-02-05 | 吴鑫 | Traditional Chinese medicine composition for cerebral arterial thrombosis |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104147161A (en) * | 2014-09-02 | 2014-11-19 | 王建国 | Medicine for treating stroke and preparation method thereof |
| KR101837444B1 (en) | 2016-10-25 | 2018-03-13 | 한국 한의학 연구원 | Composition for prevention, improvement or treatment of cognitive dysfunction comprising Potentilla fragarioides extract as effective component |
| WO2018080156A1 (en) * | 2016-10-25 | 2018-05-03 | 한국 한의학 연구원 | Composition for preventing, improving or treating cognitive impairment, containing potentilla fragarioides extract as active ingredient |
| CN107137669A (en) * | 2017-06-29 | 2017-09-08 | 河南中医药大学 | It is a kind of to treat Chinese medicine composition of cerebral apoplexy and preparation method thereof |
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