CN104147161A - Medicine for treating stroke and preparation method thereof - Google Patents
Medicine for treating stroke and preparation method thereof Download PDFInfo
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- CN104147161A CN104147161A CN201410442532.0A CN201410442532A CN104147161A CN 104147161 A CN104147161 A CN 104147161A CN 201410442532 A CN201410442532 A CN 201410442532A CN 104147161 A CN104147161 A CN 104147161A
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Abstract
The invention provides a medicine for treating stroke and a preparation method thereof. The medicine is mainly prepared from raw materials by the following steps: washing and drying an aconitum macrorhynchum tuberous root, cutting the tuberous root up to grains in the size of about 0.6-0.9 cm, placing the grains in hot water at 75-90 DEG C to soak for 30-50 min, extracting for 1-1.2 h at the temperature of 96-100 DEG C, centrifuging with a centrifugal machine and filtering, using a vacuum thickener to concentrate the liquid to obtain an extract, mixing the extract with auxiliary materials comprising a burdock extracting solution, a poncirus bark extracting solution and a vitis coignetiae extracting solution, and preparing to obtain a capsule or an oral solution. The medicine disclosed by the invention has the functions of removing heat from the liver, dispersing blood stasis and dredging collaterals, benefiting qi for activating blood circulation, restoring consciousness, promoting microcirculation and invigorating the circulation of blood, and can mainly achieve a very good treatment effect on paralysis, hemiplegia, numbness of limbs and the like caused by the stroke.
Description
Technical field
The invention belongs to technical field of Chinese medicines, concrete is a kind of medicine for the treatment of apoplexy and preparation method thereof.
Background technology
Apoplexy is also apoplexy.Be divided into two types: in ischemic cerebral apoplexy and hemorrhagic apoplexy.Apoplexy is the general designation of Chinese medicine to acute cerebrovascular disease.It is suddenly to faint, syncope, the distortion of commissure that occurs together, dysphonia and occur that hemiplegia is a class disease of cardinal symptom.Because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as its same coronary heart disease, cancer one of three large diseases that threaten human health.Hurried because falling ill, disease is seen multiterminal, and change of illness state is rapid, similar to the benefaction number change feature of wind, therefore named apoplexy, apoplexy.Primary disease often leaves sequela, and age of onset also tends to rejuvenation, therefore, is to threaten human life and the great illness of quality of life.
The traditional Chinese medical science thinks that void, fire, expectorant, wind, gas, blood are the six factors of apoplexy morbidity, and stagnation of blood stasis brain network is pathology key link.Or because of the insufficiency of blood walking retardation in children be the stasis of blood, or be the stasis of blood because blood is unable, or hand over and press from both sides because of the expectorant stasis of blood, or because of combination of phlegm and heat be the stasis of blood, or because of the hepatic and renal YIN deficiency, excessive rising of liver-YANG, make humorously fire and cause the stasis of blood, can be summarized as following six kinds: (1) liver-heat syndrome of blood stasis: be more common in the premonitory apoplexy phase or early stage, card is shown in headache, dizzy, the order flushed complexion that rises, vexed restless, numb limbs and tense tendons; (2) syndrome of blood stasis due to qi deficiency: be found in apoplexy acute attack stage, convalescent period and sequela stage, card is shown in hemiplegia, numb limbs and tense tendons, spiritlessness and weakness, dysphonia; (3) expectorant stasis blocking key card: be more common in the excess syndrome of stroke of suffering from acute stroke, card is shown in unexpected dusk servant, obnubilation, aphasia, hemiplegia of limb, gurgling with sputum, tongue has petechia or stasis of blood silk; (4) stagnant heat internal organs excess syndrome: be more common in suffering from acute stroke, card is shown in obnubilation, and hemiplegia, says that puckery language is stuttering, facial hemiparalysis, abundant expectoration vomiting and nausea; (5) cranium brain water blood stasis syndrome: be found in each phase of apoplexy, card is shown in obnubilation, and spirit depressing, crieses and laugh by turns, without any apparent reason, and limb activity is ineffective, dizzy weak, bradykinesia, crooked mouth and tongue, sialorrhea is shed tears, and food is unclear etc.; (6) blood deficiency and blood stasis card: be more common in the apoplexy later stage, card is shown in the silent aphasia of sound, cardiopalmus xerostomia, soreness of the waist and knees, hemiplegia.
At present medically for the apoplexy of the types such as liver-heat blood stasis, the deficiency of vital energy, blood deficiency especially effective medicine not also.
Summary of the invention
For solving the problem of above-mentioned existence, the invention provides a kind of medicine for the treatment of apoplexy and preparation method thereof, the especially wind-induced paralysis of centering, hemiplegia, numb limbs and tense tendons etc. have extraordinary therapeutic effect.
Technical scheme of the present invention is: a kind of medicine for the treatment of apoplexy, the primary raw material of this medicine is: spire Radix Aconiti Kusnezoffii extract 40-60 part, the preparation method of described spire Radix Aconiti Kusnezoffii extract is: spire Radix Aconiti Kusnezoffii tuber cleans up and dries, be chopped into the granule of 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, centrifugal through centrifuge 1200r/min again, filter, with the concentrated extractum that obtains of vacuum decker, take gained extractum 40-60 part,
Further, the medicine of described treatment apoplexy is prepared into oral liquid, soft capsule.
Further, the medicine of described treatment apoplexy also comprises the adjuvant of following weight portion: Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part; The preparation method of described adjuvant is: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 48-55 ℃ of condition, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
A kind of medicine for the treatment of apoplexy, its preparation method comprises the following steps: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, centrifugal through centrifuge 1200r/min again, filter, with the concentrated extractum that obtains of vacuum decker, take gained extractum 40-60 part, add again 5-8 part desiccant, then in incapsulating, obtain capsule.Described desiccant is the mixture of starch, Lactis Anhydrous and mannitol, and three's ratio is 4:1:1, take extractum when raw material is prepared capsule, owing to being rich in phlegmatic temperament, need to prevent that it from drawing wet, to increase stability.
Further, the preparation method of the medicine of described treatment apoplexy comprises the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, then, filtration centrifugal through centrifuge 1200r/min, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 48-55 ℃ of condition, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, and after mixing thoroughly, by the conventional pharmaceutical methods of pharmacy, makes oral liquid, capsule.
Further, the preparation of described capsule comprises the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, then, filtration centrifugal through centrifuge 1200r/min, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 48-55 ℃ of condition, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, and stirs, then adds 8-14 part desiccant, in then incapsulating, obtains capsule.Described desiccant is the mixture of starch, Lactis Anhydrous and mannitol, and three's ratio is: 4:1:1, take extractum when raw material is prepared capsule, and owing to being rich in phlegmatic temperament, need to prevent that it from drawing wet, to increase stability.
Further, the preparation of described oral liquid comprises the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, then, filtration centrifugal through centrifuge 1200r/min, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 48-55 ℃ of condition, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, stir, again add the pure water of 3-5 times of weight to be heated to dissolve completely, add 0.02-0.03 part antiseptic, described antiseptic is sorbic acid, regulates pH, the centrifugal 15min of rotating speed of 5000r/min, ultrafiltration CA membrane filtration, pressure is controlled within the scope of 1.2-1.6kg/cm; Standardize solution, canned, sterilizing, obtains oral liquid.
Efficacy of drugs: liver heat removing disperse blood stasis and dredge collateral, benefiting QI for activating blood circulation, refreshment are sensible, activating blood and promoting diuresis, and blood circulation promoting and blood stasis dispelling, has one's ideas straightened out and stimulate the menstrual flow;
Instructions of taking: each serving using capsule 3-6 grain or oral liquid 15-30g, early, middle and late 30 minutes after meal of every day respectively once, 21 days was a course for the treatment of, and take effect a course for the treatment of, and heal three to six courses for the treatment of;
Applicable crowd: in the patient such as wind-induced paralysis, hemiplegia, numb limbs and tense tendons;
The character of selected each medicine of the present invention is respectively:
1. spire Radix Aconiti Kusnezoffii
[nature and flavor]: acrid in the mouth; Warm in nature; Poisonous;
[function cures mainly]: expelling wind and dampness; Open expectorant detumescence.Main air pain of dampness syndrome; Numb limbs and tense tendons; Paralysis due to windstroke; Carbuncle; Do not burst; Furuncle from the beginning of; Swollen hard pain.
2. purple Pueraria lobota
[nature and flavor]: sweet; Micro-hardship; Cold; Nontoxic;
[function cures mainly]: heat clearing away tonify deficiency; Dissipating blood stasis dredging collateral; Removing toxic substances.Restlessness and thirst after main product; Apoplexy and hemiplegia; Traumatic injury; Carbuncle malignant boil.
3. Cortex Ponciri trifoliatae
[nature and flavor]: pungent; Temperature;
[return through]: liver; Kidney channel;
[function cures mainly]: endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.Main apoplexy orthotonus; Joint stuffiness; Mouth eye (mouthful Guo) tiltedly.
4. Fructus Arctii
[nature and flavor]: hardship; Pungent; Cold;
[function cures mainly]: heat-clearing and toxic substances removing, dispelling wind sore-throat relieving, blood sugar lowering, blood pressure lowering, blood fat, punish-old year apoplexy.
Above-mentioned Chinese medicinal ingredients is through checking for many years, record and test gained, although their effect is different, but choosing of each Chinese medicine is not to be arbitrarily, the applicant is according to the proportioning of each composition of test gained for many years, be not by the raw material effect simple superposition of each composition, because may there is interpromoting relation in five elements between various raw material of Chinese medicine, mutual reinforcement between, the multiple interactively such as mutual restraint between two drugs or the mutual-detoxication, and the applicant has selected above-mentioned raw materials accordingly according to this principle exactly, and determined the best proportioning between them, obtained the approval of clinical trial therefore, the application has significant meaning.
Beneficial effect of the present invention is: medicine of the present invention can liver heat removing disperse blood stasis and dredge collateral, benefiting QI for activating blood circulation, refreshment are sensible, activating blood and promoting diuresis, the main wind-induced paralysis of centering, hemiplegia, numb limbs and tense tendons etc. have extraordinary therapeutic effect, and the selected medicine of the present invention is through verifying for many years, record and test gained, prescription is rigorous, each medicine coordinates rationally, bring out the best in each other, without any side effects.
The specific embodiment
Below in conjunction with the specific embodiment, describe ingredients of the present invention and preparation method thereof in detail.
Embodiment 1:
Treat a medicine for apoplexy, the primary raw material of this medicine is: 40 parts of spire Radix Aconiti Kusnezoffii extracts; The preparation method of described spire Radix Aconiti Kusnezoffii extract is: spire Radix Aconiti Kusnezoffii tuber cleans up and dries, be chopped into the granule of 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h, whole leaching process keeps steady temperature, and material is heated evenly, to improve quality of liquid medicine,, filtration centrifugal through centrifuge 1200r/min again, obtains extractum with vacuum decker is concentrated, takes 40 parts of gained extractum;
The preparation method of this medicine is:
Spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into the granule of 0.6cm size, then the hot water of putting into 75 ℃ infiltrates 30min, under 96 ℃ of conditions, extract 1h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, centrifugal through centrifuge 1200r/min again, filter, with the concentrated extractum that obtains of vacuum decker, take 40 parts of gained extractum, add again 5 parts of desiccant, wherein, described desiccant is starch, the mixture of Lactis Anhydrous and mannitol, three's ratio is: 4:1:1, take extractum when raw material is prepared capsule, owing to being rich in phlegmatic temperament, need to prevent that it from drawing wet, to increase stability, then, in incapsulating, obtain capsule.
Embodiment 2:
A kind of medicine for the treatment of apoplexy, comprise major ingredient and adjuvant: the preparation method of described major ingredient is: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.75cm size, then the hot water of putting into 82 ℃ infiltrates 40min, under 98 ℃ of conditions, extract 1.1h, whole leaching process keeps steady temperature, and material is heated evenly, to improve quality of liquid medicine,, filtration centrifugal through centrifuge 1200r/min again, obtains extractum with vacuum decker is concentrated, takes 50 parts of gained extractum;
The preparation method of described adjuvant is: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 51.5 ℃ of conditions, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively 7.5 parts of gained Fructus Arctii extracting solution, 11 parts of Cortex Ponciri trifoliatae extracting solution, 6 parts of purple Pueraria lobota extracting solution;
The preparation method of this medicine is:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.75cm size, then the hot water of putting into 82 ℃ infiltrates 40min, under 98 ℃ of conditions, extract 1.1h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, then, filtration centrifugal through centrifuge 1200r/min, with vacuum decker is concentrated, obtain extractum, take 50 parts of gained extractum;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 51.5 ℃ of conditions, then use vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively 7.5 parts of gained Fructus Arctii extracting solution, 11 parts of Cortex Ponciri trifoliatae extracting solution, 6 parts of purple Pueraria lobota extracting solution;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, stir, add again 11 parts of desiccant, wherein, described desiccant is the mixture of starch, Lactis Anhydrous and mannitol, and three's ratio is: 4:1:1, take extractum when raw material is prepared capsule, owing to being rich in phlegmatic temperament, need to prevent that it from drawing wet, to increase stability; Then, in incapsulating, obtain capsule.
Embodiment 3:
A kind of medicine for the treatment of apoplexy, comprise major ingredient and adjuvant: the preparation method of described major ingredient is: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.9cm size, then the hot water of putting into 90 ℃ infiltrates 50min, under 100 ℃ of conditions, extract 1.2h, whole leaching process keeps steady temperature, and material is heated evenly, to improve quality of liquid medicine,, filtration centrifugal through centrifuge 1200r/min again, obtains extractum with vacuum decker is concentrated, takes 60 parts of gained extractum;
The preparation method of described adjuvant is: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 55 ℃ of conditions, ultrasound wave produces at a high speed, strong cavitation effect and stirring action, destroy the cell of vegetable drug, solvent is penetrated in crude drug cell, shortens extraction time, improve extraction ratio; Use again vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively 10 parts of gained Fructus Arctii extracting solution, 14 parts of Cortex Ponciri trifoliatae extracting solution, 9 parts of purple Pueraria lobota extracting solution;
The preparation method of this medicine is:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.9cm size, then the hot water of putting into 90 ℃ infiltrates 50min, under 100 ℃ of conditions, extract 1.2h, whole leaching process keeps steady temperature, material is heated evenly, to improve quality of liquid medicine, then, filtration centrifugal through centrifuge, with vacuum decker is concentrated, obtain extractum, take 60 parts of gained extractum;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction 30min under 55 ℃ of conditions, then use vacuum filtration machine intermittent filtration, obtain Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively 10 parts of gained Fructus Arctii extracting solution, 14 parts of Cortex Ponciri trifoliatae extracting solution, 9 parts of purple Pueraria lobota extracting solution;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, stir, again add the pure water of 5 times of weight to be heated to dissolve completely, add 0.03 part of antiseptic sorbic acid, regulate pH, the centrifugal 15min of rotating speed of 5000r/min, ultrafiltration CA membrane filtration, pressure is controlled within the scope of 1.6kg/cm, standardize solution, canned, sterilizing, obtains oral liquid.
Type testing example:
1. patient Lee, man, 45 years old, people from Linqu County, Shandong Province, cause orthotonus because of apoplexy in April, 2013, and arms and legs joint stuffiness is walked unstable, fall ill and after 10 days, take the medicine of the treatment apoplexy of the embodiment of the present invention 1 preparation, after two courses for the treatment of, take effect, trick function makes moderate progress, capable of expansion and contraction after five courses for the treatment of, be diagnosed as rehabilitation, within 1 year, pay a return visit afterwards not recurrence.
2. patient Wu: female, 58 years old, people from Linqu County, Shandong Province, in March, 2013 because of apoplexy cause left side hemiplegia, left side trick function serious hindrance, hands can not be taken thing, foot can not be walked, the medicine of taking the treatment apoplexy of the embodiment of the present invention 2 preparations after 20 days, took effect after the course for the treatment of, and left side trick function makes moderate progress, hands is movable, foot can be stood and small step walking, and not recurrence is paid a return visit in rehabilitation after four courses for the treatment of for 1 year afterwards.
3. patient Wu: female, 62 years old, people from Linqu County, Shandong Province, in April, 2013 because of apoplexy cause left side hemiplegia, left side trick function serious hindrance, trick is stiff, be unable to stir any more, the medicine of taking the treatment apoplexy of the embodiment of the present invention 3 preparations, took effect after three courses for the treatment of, and left side trick function makes moderate progress, hands is movable, foot can be stood and small step walking, and not recurrence is paid a return visit in rehabilitation after six courses for the treatment of for 1 year afterwards.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (8)
1. a medicine for the treatment of apoplexy, the primary raw material that it is characterized in that this medicine is: spire Radix Aconiti Kusnezoffii extract 40-60 part, the preparation method of described spire Radix Aconiti Kusnezoffii extract is: spire Radix Aconiti Kusnezoffii tuber cleans up and dries, be chopped into the granule of 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extracts 1-1.2h, then, filtration centrifugal through centrifuge, with vacuum decker is concentrated, obtain extractum, be spire Radix Aconiti Kusnezoffii extract.
2. the medicine for the treatment of apoplexy according to claim 1, is prepared into oral liquid, soft capsule.
3. the preparation method of the medicine for the treatment of apoplexy according to claim 1, is characterized in that comprising the following steps:
Spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into the granule of 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h,, filtration centrifugal through centrifuge again, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part, then add 5-8 part desiccant, then, in incapsulating, obtain capsule.
4. the medicine for the treatment of apoplexy according to claim 1, is characterized in that this medicine also comprises the adjuvant of following weight portion: Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part; The preparation method of described adjuvant is: Fructus Arctii is pulverized with pulverizer, and 80 orders sieve, ultrasonic extraction, and vacuum filtration machine filters, and obtains Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part.
5. the preparation method of the medicine for the treatment of apoplexy according to claim 4, is characterized in that comprising the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h,, filtration centrifugal through centrifuge again, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction, vacuum filtration machine filters, and obtains Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, and after mixing thoroughly, by the conventional pharmaceutical methods of pharmacy, makes oral liquid, capsule.
6. the preparation method of the medicine for the treatment of apoplexy according to claim 5, is characterized in that the preparation of described capsule comprises the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h,, filtration centrifugal through centrifuge again, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction, vacuum filtration machine filters, and obtains Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, and stirs, then adds 8-14 part desiccant, in then incapsulating, obtains capsule.
7. the preparation method of the medicine for the treatment of apoplexy according to claim 5, is characterized in that the preparation of described oral liquid comprises the following steps:
(1) preparation of major ingredient: the granule that the spire Radix Aconiti Kusnezoffii tuber after cleaning up and drying is chopped into 0.6-0.9cm size, then the hot water of putting into 75-90 ℃ infiltrates 30-50min, under 96-100 ℃ of condition, extract 1-1.2h,, filtration centrifugal through centrifuge again, with vacuum decker is concentrated, obtain extractum, take gained extractum 40-60 part;
(2) preparation of adjuvant: Fructus Arctii is pulverized with pulverizer, 80 orders sieve, ultrasonic extraction, vacuum filtration machine filters, and obtains Fructus Arctii extracting solution; Cortex Ponciri trifoliatae and purple Pueraria lobota use the same method to extract and obtain Cortex Ponciri trifoliatae extracting solution and purple Pueraria lobota extracting solution; Take respectively gained Fructus Arctii extracting solution 5-10 part, Cortex Ponciri trifoliatae extracting solution 8-14 part, purple Pueraria lobota extracting solution 3-9 part;
(3) extractum step (1) being made mixes with all extracting solution that step (2) makes, stir, again add the pure water of 3-5 times of weight to be heated to dissolve completely, add 0.02-0.03 part antiseptic, regulate pH, the centrifugal 15min of rotating speed of 5000r/min, ultrafiltration CA membrane filtration, standardize solution, canned, sterilizing, obtains oral liquid.
8. according to the preparation method of the medicine of the treatment apoplexy described in claim 3 or 6, it is characterized in that described desiccant is the mixture of starch, Lactis Anhydrous and mannitol, three's ratio is: 4:1:1.
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| CN103393941A (en) * | 2013-07-29 | 2013-11-20 | 刘庆华 | Drug for treating cerebral infarction |
| CN103585503A (en) * | 2013-11-06 | 2014-02-19 | 潍坊诺达药业有限公司 | Traditional Chinese medicine composition for treating hemorrhagic strokes |
| CN103830482A (en) * | 2014-04-02 | 2014-06-04 | 王凤霞 | Traditional Chinese medicine preparation for treating stroke and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103393941A (en) * | 2013-07-29 | 2013-11-20 | 刘庆华 | Drug for treating cerebral infarction |
| CN103585503A (en) * | 2013-11-06 | 2014-02-19 | 潍坊诺达药业有限公司 | Traditional Chinese medicine composition for treating hemorrhagic strokes |
| CN103830482A (en) * | 2014-04-02 | 2014-06-04 | 王凤霞 | Traditional Chinese medicine preparation for treating stroke and preparation method thereof |
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| 杨淳彬等: "细叶草乌的化学成分研究", 《应用与环境生物学报》 * |
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