KR100743205B1 - Anti-atopic cosmetic composition - Google Patents

Abstract

The present invention has the effect of ameliorating or alleviating the symptoms of atopic dermatitis, including natural ingredients such as golden, red ginseng, ringworm, tongpi, seon, baekryeung, cinnamon, donkey, seaweed, aloe, apricot ingredients, etc. It relates to a functional cosmetic composition with less side effects and skin irritation. According to the present invention, it is possible to alleviate or improve the symptoms of atopic dermatitis without various side effects that occur when taking long-term treatment with oral medications, injections, ointments, etc., especially young adults, infants and children with a high probability of developing atopic dermatitis as well as adults. There is a big effect that can be used.

Atopic Dermatitis, Moisturizing, Atopic Treatment, Itching, Dermatitis

Description

Functional cosmetic composition effective for atopic dermatitis

1 is a diagram showing a process of far-infrared treatment of a cosmetic composition of the present invention.

Figure 2 is a graph analyzing the far infrared rays stored in the skin lotion of the present invention treated with far infrared rays.

3 is a graph analyzing the far infrared rays stored in the milk lotion of the present invention treated with far infrared rays.

The present invention relates to a functional cosmetic composition effective in atopic dermatitis, and more particularly has an effect of ameliorating or alleviating the symptoms of atopic dermatitis, golden, ginseng, ringworm, tongpi, seon, baekbaek, tobokyeong, cinnamon It relates to a cosmetic composition containing less natural side effects and skin irritation, including natural ingredients such as Angelica, Angelica, seaweed, aloe, apricot ingredients.

'Atopy' means 'inappropriate' or 'unusual', which was named by A. Coca in 1925 about the innate hypersensitivity to certain kinds of human-specific substances. High fever, asthma, atopic dermatitis, etc. are high in the family, and the positive rate of intradermal reaction against various allergens (eg egg white, dandruff, pollen, dust, etc.) is high. Antibodies (atopic allergens), blood eosinophilia, and abnormal reactions to various stresses (temperature, humidity, trauma, mental strain, infection, etc.) appear. The establishment of this concept of atopy has made great strides in elucidating the etiology of children's asthma and atopic dermatitis.

Many people suffer from atopic dermatitis. Atopic dermatitis is a very itchy eczema that occurs in people with atopic dermatitis. The cause of atopic dermatitis is not well known, but there are many genetic factors and it is related to the deficiency of the immune system.In addition, dry skin, the characteristics of skin itching easily compared to normal people, infections caused by bacteria, viruses, and fungi, emotional factors, environment It is estimated that these factors are caused by the complex action of each other.

Infants are commonly referred to as 'fever', so only young children are known to have it but are often found in adults. In general, during the neonatal period, the appearance of the ulcer centers around the face, but gradually expands into the body as it ages, and changes to a rough and dry form, and the lesion is often severely folded.

In Korea, about 20% of people suffer from atopic dermatitis, including 25% of children under 2 years of age, 70% of children aged 2 to 10 years, and 5% of adolescents and adults over 11 years of age. Occupies. The treatment for atopic dermatitis used in Korea is in the form of internal medicines, including steroid ointments and injections, which are mostly sold in hospitals / clinics or pharmacies.

However, steroids can cause dermatitis, candida, ringworm (fungal) and malleable impetigo, folliculitis (bacterial), steroid acne, perioral dermatitis, steroid dermatitis, sunburn, purpura, hairy and pigmentary discoloration, skin irritation, rash Side effects such as causing skin diseases of the back, inhibiting the function of the pituitary gland and the adrenal cortex, and causing cataracts have already been reported in the medical community. In addition, in the case of oral medicines containing injections, skin diseases such as subcutaneous blood, pigmentation, purpura, acne, hair loss, hair loss, ancestors, itching, sweating abnormalities, facial erythema, needle healing disorders, skin thinning, and softening; Endocrine disorders such as secondary adrenal insufficiency, diabetes mellitus, dysmenorrhea; Digestive system abnormalities such as peptic ulcer, gastritis, hari, nausea, vomiting, stomach pain, heartburn, dry mouth, anorexia, and anorexia; Mental nervous system abnormalities such as mental alteration, depressed state, gladness, headache, dizziness, cramps, and insomnia; Muscle and skeletal abnormalities such as osteoporosis, femoral head and humerus, aseptic necrosis, myopathy, arthralgia, etc .; Lipid / protein metabolic disorders such as full moon face, night mare, nitrogen imbalance, fatty liver, etc .; Body fluids such as edema, elevated blood pressure, hypokalemia, and electrolyte system abnormalities; And eye related abnormalities such as hypertension, glaucoma, posterior capsular cataract, and retinal disorder ocular protrusion.

Atopic dermatitis is more prevalent in infants and children than adults, especially 75% of infancy patients before 1 year of age, it is difficult to cure once it is important to attenuate symptoms early in the onset. However, in the case of young infants and children, the side effects of the aforementioned therapeutic drugs are more serious than in adults, and thus the treatment is very difficult.

The present invention is to solve the above problems, by combining a natural herbal material having a pharmacological action, such as skin moisturization and dermatitis, so as not to show skin side effects in adults as well as young children, and can maximize the pharmacological action of herbal ingredients By storing the far-infrared wavelength in the product, the present invention has been completed by developing a cosmetic composition having a skin moisturizing effect and an effect of improving or alleviating the symptoms of atopic dermatitis.

The present invention is golden, red ginseng, ringworm, tongpi, cinnamon, donkey, phalaenopsis, cinnamon, donkey, sentence pattern, ivy, kiwi, wild stalk, buckwheat, allantoin, rosemary, agaricus, salva, chamomile, fern, loofah It provides a functional cosmetic composition comprising the seaweed, aloe, apricot and cucumber components, and is effective for atopic dermatitis.

The primary goal of treating atopic dermatitis is to relieve itching and dermatitis. Itching and scratching the skin blocks the vicious cycle that causes dermatitis to itch again.

The inventors of the present invention, while conducting research on cosmetics effective for atopic dermatitis, select herbal ingredients with antibacterial, moisturizing, soothing, and anti-inflammatory effects, and they are fixed in a weight ratio, preferably 5: When used in a mixture of 3: 2 ratio, they were found to have a better effect on atopic dermatitis than when used individually or in other ratios.

The detailed contents of each effective herbal ingredients were first determined in a preliminary range by referring to various herbal booklets, and the effect of each of the contents was examined through an effect test of 30 adult atopic dermatitis patients. The final decision was made by adjusting the ramp.

Because these herbal ingredients are natural plant ingredients, they are safe and less irritating to the human body, and they can neutralize or even relieve chemical ingredients from other cosmetic ingredients that are mixed by the pharmacological action of the material itself. It can be usefully used for sleeping or skin disease patients, especially for atopic dermatitis patients, especially infants who are difficult to treat medication.

Hereinafter, the present invention will be described in detail.

When the functional cosmetic composition of the present invention based on a total of 150ml, golden 1.0 ~ 5.0g as powder, red ginseng 1.0 ~ 5.0g, white pine skin 0.5 ~ 1.5g, crypt skin 0.5 ~ 2.0g, ground 2.0 ~ 4.0g, Platinum 0.5 ~ 2.0g, Tobokyeong 1.0 ~ 3.0g, Cinnamon 0.5 ~ 1.0g, Angelica 1.0 ~ 2.0g, Moon pattern 1.0 ~ 5.0g, Ivy 3.0 ~ 5.0g, Kiwi 0.5 ~ 1.5g, Wild Thigh 3.0 ~ 7.0g, Buckwheat 5.0 ~ 6.0g, Allantoin 0.5 ~ 3.0g, Rosemary 0.5 ~ 2.5g, Agaricus 1.0 ~ 5.0g, Salvia 1.0 ~ 3.0g, Chamomile 0.5 ~ 1.5g, Fern Root 2.0 ~ 4.0g, Scrubber 1.0 ~ 3.0g, Contains 1.0-3.0 g of seaweed, 1.0-3.0 g of aloe, 1.0-3.0 g of apricots and 1.0-3.0 g of cucumbers. At this time, other parts except for these components are the same as in the manufacture of general cosmetics, the content can be adjusted within the above range according to the formulation of the composition.

The content of the added material was determined as a result of preliminary experiments, and since each material is a natural vegetable ingredient and is not harmful to the human body, even if some ingredients deviate from the prescribed content, the effect on atopic dermatitis is greatly reduced. However, it is most effective to follow the above content ratio.

The compositions of the present invention may be prepared in any of the formulations conventionally made in the art and include, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, cleansing, oils, foundations, It may be formulated in a spray or the like, but is not limited thereto, and may be appropriately selected depending on the intended use. For example, in the case of children or infants, the subject may be prepared in the form of skin lotion or milk lotion, shampoo, soap, cream, etc., and in the case of an adult woman, may be prepared in the form of cosmetic or cosmetic cosmetics. .

In addition, the composition of the present invention can be treated to store far-infrared wavelengths in order to maximize the pharmacological effect of the herbal components contained in the composition. The composition treated in the same manner as in FIG. 1 may increase the effect by allowing the herbal components that exhibit pharmacological activity to be released when the far-infrared wavelength stored therein is also released or by promoting absorption into the skin.

In addition, far-infrared rays continue to act on the human body by itself, resulting in thermal effects (improvement of heart blood circulation), magnetism (stiff shoulders, prevention of numbness of hands and feet), wet and dry action (resilience skin maintenance), neutralization (lipid breakdown, odor removal). It is known to affect the maturation effect (growth, physical rhythm development), metabolic action (diabetes ebang, atopy), and this side effect can be expected.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention and the scope of the present invention is not limited to the following examples.

Example 1 Preparation of Skin Lotion

Skin lotion is prepared by dividing the alcohol portion, purified water portion and natural herbal portion based on a total 150ml. Materials included in each part is shown in Table 1 below, and other raw materials are the same as in general cosmetics.

First, the material belonging to the ethanol portion was melted at 85 ° C. in the order described in Table 1 until the state became transparent. At this time, the used ethanol was produced in a grain and distilled at 78 ℃ was used 99.9% purity.

Next, the material belonging to the part of purified water was melt | dissolved similarly in 85 degreeC in the order of Table 1, until the state became transparent. At this time, the purified water was sterilized and used for microelement treatment.

Finally, the natural herb portion was added distilled water corresponding to 10 times the weight of the total herbal powder and then extracted with hot water at 90 ~ 100 ℃, it was repeatedly extracted three times for 8 hours. The extract was concentrated under reduced pressure to obtain 10 g of the extract, which was used as a raw material of natural herbs.

A skin lotion was prepared by mixing the ethanol portion, the purified water portion, and the natural herbal portion prepared above and stirring until it became a transparent phase.

Composition of skin lotion composition (150 ml total) Raw material Classification Material name Gram Classification Material name Gram     Alcohol part ethanol 6.5     Purified water part Purified water 11.5 Phyto collagen 0.2 Sodium citrate 0.7 Germall 0.2 0.5% Na-hyaluronic acid (Na-hyaluronate) 7.0 Amino coat 0.7 glycerin 3.5      Natural herbal part Gold 2.2      Natural herbal part buckwheat 5.5 Gosam 1.8 Allantoin 0.8 Ringworm 1.1 Rosemary 2.1 Topikin 1.7 Agaricus 2.5 Digression 2.6 Salvia 1.6 White 1.2 Chamomile 1.2 Tobok Spirit 2.2 Sunny place 3.2 cinnamon 0.7 Scrubbers 2.0 Donkey 1.2 seaweeds 2.0 Sentence 1.5 Aloe 2.0 Ivy 3.2 apricot 2.0 Kiwi 0.9 cucumber 2.0 Wild Thigh 4.5

Example 2 Preparation of Milk Lotion

Milk lotion was prepared by dividing the alcohol portion, purified water portion and natural herbal portion based on a total of 150ml. Materials included in each part are shown in Table 2 below, and other raw materials are the same as general cosmetics.

First, materials belonging to the ethanol portion were mixed at 85 ° C. in the order described in Table 2. At this time, the ethanol used was produced in a grain and distilled at 78 ℃ 99.9% purity was used.

Next, the materials belonging to the purified water part were similarly mixed in the order described in Table 2 at 85 ° C. At this time, the purified water was sterilized and used for microelement treatment.

Finally, the natural herb portion was added distilled water corresponding to 10 times the weight of the total herbal powder and then extracted with hot water at 90 ~ 100 ℃, it was repeatedly extracted three times for 8 hours. The extract was concentrated under reduced pressure to obtain 10 g of the extract, which was used as a raw material of natural herbs.

The ethanol portion, purified water portion and natural herbal portion prepared above were mixed, heated to 65-75 ° C., stirred and cooled to 35-45 ° C. to prepare a milk lotion.

Composition of milk lotion composition (150 ml total) Raw material Classification Material name Gram Classification Material name Gram      Alcohol part ethanol 2.0            Natural herbal part Tobok Spirit 1.4 glycerin 1.5 cinnamon 0.7 Squalane 0.7 Donkey 1.2 Lanette-0 1.3 Sentence 4.5 Olive 1000 2.7 Ivy 4.7 Macadamia nut oil 4.8 Kiwi 0.5 Sepigel 305 1.1 Wild Thigh 6.6 Allantoin 0.5 buckwheat 5.5 DL-panthenol 3.2 Allantoin 2.8 glycerin 7.5 Rosemary 1.1   Purified water part Purified water 11.5 Agaricus 2.5 GMS # 205 0.8 Salvia 1.6 Alacel # 165 1.5 Chamomile 1.2 Tween # 80 2.1 Birch roots 2.5   Natural herbal part Gold 2.5 Scrubbers 2.0 Alpine 2.8 seaweeds 2.8 Ringworm 1.1 Aloe 2.0 Topikin 0.7 apricot 2.0 Digression 3.6 cucumber 2.0 White 0.5

Example 3 Far Infrared Treatment of Cosmetics

The skin lotion and milk croshon prepared in Examples 1 and 2 were treated with far-infrared rays in the same manner as in FIG. 1 to store far-infrared rays in cosmetics. Common light sources include ultraviolet light, visible light, and infrared light. Therefore, only the infrared wavelength range of 0.75 ~ 20㎛ excluding the ultraviolet and visible portion through the wavelength sorter was irradiated to the product.

And, the far infrared rays stored in the product thus processed were analyzed. As a result, the far-infrared wavelengths stored in the far-infrared irradiated skin lotion and milk croshon were 5-20 μm. As shown in FIGS. 2 and 3, the emissivity at 37 ° C. was 0.910 and 0.912, respectively, and the amount of radiation energy was 3.51 × 10 ^2. (W / m ² · μm, 37 ° C) and 3.50 × 10 ² (W / m ² · μm, 37 ° C).

Test Example 1 skin irritation test

In order to examine the skin irritation of the product prepared in Examples 1 to 3 at all times, gauze coated with about 1 ml of the product was applied to the 5 x 5 cm area of the lower arm of both arms for 50 normal people and 70 patients with atopic dermatitis. After 24 hours. After 1 hour, the skin condition was visually confirmed and the results are shown in Table 3 below.

Skin irritation test result division Target (age) Number of people Judgment result Irritation degree (%) ++ + +- -  Normal people 0-2 years old 10 0 0 One 9 3.33 3-10 years old 10 0 0 One 9 3.33 10 years old or older 30 0 0 One 29 1.11  Atopic patients 0-2 years old 20 0 One One 18 5.00 3-10 years old 20 0 0 One 19 1.67 10 years old or older 30 0 0 One 29 1.11

* Criteria

-: No erythema or unusual phenomenon

+-: Slightly reddish

+: Significantly redder than the surroundings

++: Severe reddening and swelling around

* Stimulus (%)

= [(+-) Number x 1 + (+) number x 2 + (++) number x 3] x 100 / [number of subjects x 3]

As shown in the results of the table, it was confirmed that the product produced through the present invention did not cause any special irritation to the skin, and did not cause skin irritation or side effects in atopic dermatitis patients as well as normal people.

Test Example 2 : Effect test for atopic dermatitis

In order to find out the effect on the atopic dermatitis of the product prepared in Example 1 to 3, a total of 160 patients with atopic dermatitis after using the prepared product twice a day for two months in the morning and evening The improvement of atopic dermatitis was confirmed by the questionnaire response by the investigator himself / herself (in the case of infants and infants) and by the observer's visual evaluation. The results are shown in Table 4 below.

Effect test results for atopic dermatitis Target (age) Number of people result ++ + +- - % Improvement 0-1 years old 15 7 4 4 0 73.33 1-3 years old 25 15 4 5 One 76.00 4-7 years old 30 19 5 4 2 80.00 8-13 years old 30 22 3 5 0 83.33 14-20 years old 30 18 6 6 0 80.00 21-40 years old 20 14 3 3 0 85.00 41 years old or older 10 4 3 3 0 70.00 system 160 99 28 30 3 79.38

* Criteria

++: very good +: good

+-: No change-: Poor

*% Improvement

= [(++) number + (+) number] x 100 / number of subjects

As shown in the results of the above table, the product of the present invention showed an improvement effect in about 80% of patients with atopic dermatitis, thereby confirming that the product of the present invention has the effect of improving or alleviating the symptoms of atopic dermatitis. In addition, only 3 out of 160 people, corresponding to about 2%, do not improve the condition, it is determined that the product of the present invention does not cause any special side effects.

As described in detail above, the present invention has the effect of ameliorating or alleviating the symptoms of atopic dermatitis, golden, red ginseng, ringworm, tongpi, seon, baekryeok, bokbokyeong, cinnamon, Angelica, sentence, ivy, kiwi, It provides a functional cosmetic composition with less side effects or skin irritation, including natural ingredients such as wild stalk, buckwheat, allantoin, rosemary, agaricus, sage, chamomile, birch root, loofah, seaweed, aloe, apricot and cucumber. According to the present invention, it is possible to alleviate or improve the symptoms of atopic dermatitis without various side effects that occur when taking long-term treatment with oral medications, injections, ointments, etc., especially young adults, infants and children with a high probability of developing atopic dermatitis as well as adults. There is a big effect that can be used. As a result, the pain of patients and their families caused by atopic dermatitis can be solved, thereby contributing to national health.

Claims (3)

Golden, red ginseng, ringworm, topi, cinnamon, donkey, sentence, ivy, kiwi, wild squid, buckwheat, allantoin, rosemary, agaricus, salva, chamomile, birch root, loofah, seaweed, A functional cosmetic composition comprising aloe, apricot and cucumber powder, effective in atopic dermatitis. According to claim 1, wherein the herbal powder is based on a total of 150ml, golden 1.0 ~ 5.0g as powder, red ginseng 1.0 ~ 5.0g, white pine skin 0.5 ~ 1.5g, Tohpi skin 0.5 ~ 2.0g, sediment 2.0 ~ 4.0g, White 0.5 ~ 2.0g, Tobokyeong 1.0 ~ 3.0g, Cinnamon 0.5 ~ 1.0g, Angelica 1.0 ~ 2.0g, Moon 1.0 ~ 5.0g, Ivy 3.0 ~ 5.0g, Kiwi 0.5 ~ 1.5g, Wild Thigh 3.0 ~ 7.0g, buckwheat 5.0 ~ 6.0g, allantoin 0.5 ~ 3.0g, rosemary 0.5 ~ 2.5g, agaricus 1.0 ~ 5.0g, salvia 1.0 ~ 3.0g, chamomile 0.5 ~ 1.5g, birch root 2.0 ~ 4.0g, loofah 1.0 ~ A functional cosmetic composition comprising 3.0 g, seaweed 1.0-3.0 g, aloe 1.0-3.0 g, apricot 1.0-3.0 g, and cucumber 1.0-3.0 g. According to claim 1 or 2, wherein the composition is treated to store the far infrared wavelength, the treatment is irradiated to the composition by fractionating only the infrared wavelength range of 0.75 ~ 20㎛ excluding the ultraviolet and visible light portion through a wavelength sorter And, the functional cosmetic composition, characterized in that the far-infrared wavelength of 5 ~ 20㎛ is stored in the composition treated with far infrared rays.

Images