KR100987974B1 - Ointment treating for atopic dermatitis - Google Patents

Ointment treating for atopic dermatitis Download PDF

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KR100987974B1
KR100987974B1 KR1020080049505A KR20080049505A KR100987974B1 KR 100987974 B1 KR100987974 B1 KR 100987974B1 KR 1020080049505 A KR1020080049505 A KR 1020080049505A KR 20080049505 A KR20080049505 A KR 20080049505A KR 100987974 B1 KR100987974 B1 KR 100987974B1
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atopic dermatitis
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엄용태
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Abstract

본 발명은 아토피성피부 개선용 연고에 관한 것으로, 구체적으로는 참기름 100중량부에 대하여, 석밀 10~20중량부, 돈지 0.5~1.5중량부, 당귀 3~7중량부, 백선피 3~7중량부, 백급 3~7중량부, 산자고 3~7중량부, 자초 3~7중량부, 유황 3~7중량부, 황토 3~7중량부, 사상자 3~7중량부를 이용하여 제조한다.The present invention relates to an ointment for improving atopic dermatitis, specifically, 10 to 20 parts by weight, 0.5 to 1.5 parts by weight of larch, 3 to 7 parts by weight, donkey 3 to 7 parts by weight, 100 g of sesame oil. It is prepared using parts, 3-7 parts by weight, 3-7 parts by weight of acid, 3-7 parts by weight, 3-7 parts by weight of sulfur, 3-7 parts by weight of sulfur, 3-7 parts by weight of ocher, and 3-7 parts by weight of casualty.

본 발명에 따른 아토피성피부 개선용 연고는 한약재로 사용되어온 천연성분들로 이루어져 장기간 사용시에도 부작용이 발생하지 않으며, 아토피성피부염, 습진, 건선으로 인한 발적, 삼출, 낙설, 가려움증 등의 증상을 개선하는 효과가 있다.The ointment for improving atopic dermatitis according to the present invention is composed of natural ingredients that have been used as herbal medicines and does not cause side effects even after long-term use, and improves symptoms such as redness, exudation, abortion, and itching due to atopic dermatitis, eczema and psoriasis. It is effective.

연고, 아토피성피부염, 습진, 건선, 백선피, 백급, 산자고, 자초, 유황, 황토, 사상자. Ointments, atopic dermatitis, eczema, psoriasis, ringworm skin, urticaria, live algae, vinegar, sulfur, ocher, casualties.

Description

아토피성피부 개선용 연고 {Ointment treating for atopic dermatitis}Ointment treating for atopic dermatitis}

본 발명은 아토피성피부 개선용 연고에 관한 것으로, 구체적으로는 참기름, 석밀, 돈지, 당귀, 백선피, 백급, 산자고, 자초, 유황, 황토, 사상자 성분을 함유하는 연고에 관한 것이다.The present invention relates to an ointment for improving atopic dermatitis, and in particular, to an ointment containing sesame oil, stone wheat, larch, donkey, ringworm skin, baekrye, sanja, vinegar, sulfur, ocher and casualty components.

아토피성 피부염은 피부건조증과 가려움증을 주로 나타내는 만성피부질환으로, 때로는 발적, 삼출, 낙설 등의 증상을 동반하기도 한다. 아토피성 피부염의 원인은 명확히 밝혀지지는 않았으나 유전적인 요소가 가장 큰 것으로 알려져 있으며, 면역학적 반응의 이상, 피부보호막의 이상이 그 원인으로 지목되고 있으며, 그 외에 환경적인 요인도 영향을 미치는 것으로 알려져 있다.Atopic dermatitis is a chronic skin disease that primarily causes dry skin and itching. Sometimes atopic dermatitis is accompanied by symptoms such as redness, exudation, and abortion. The cause of atopic dermatitis is not clear, but the genetic factor is known to be the largest, and the cause of abnormal immunological reactions and abnormalities of the skin barrier is known to have an influence on environmental factors. have.

아토피성 피부염은 그 원인이 불명인 만큼 명확한 치료법도 제시되어 있지 못한 상태이다. 따라서, 환부를 통한 감염을 방지함으로써 증상의 악화를 막고, 충분한 보습 및 항히스타민제의 투여 등을 통하여 가려움증을 줄이거나 스테로이드 제제를 일시적으로 사용하는 등의 처치가 주로 행해지고 있다.As atopic dermatitis is unknown, there is no clear treatment. Therefore, prevention of infection through the affected area is prevented from worsening the symptoms, and treatment such as reducing the itching or temporarily using a steroid preparation through sufficient moisturizing and antihistamine administration is mainly performed.

그러나, 상기 처치방법으로는 아토피성 피부염의 증상이 일시적으로 완화되 는 것일 뿐 근본적인 치료가 되는 것은 아니므로, 반복적인 재발을 방지하기 위해서는 치료를 지속할 필요가 있는 반면, 항히스타민제나 스테로이드제제는 장기간 투여시 그 부작용으로 인하여 안전성이 떨어지는 약물로서 장기간 사용하는 약물로는 부적합하다. However, the above treatment method only temporarily alleviates the symptoms of atopic dermatitis, and thus is not an essential treatment. Therefore, it is necessary to continue treatment to prevent recurrence, whereas antihistamines or steroids may be used for a long time. It is inadequate for long-term use as a drug with low safety due to its side effects when administered.

따라서, 본 발명에서는 오랜 기간 동안 한약재로서 사용되어온 천연재료를 사용하여, 장기간 사용시에도 부작용이 적은 연고를 제공하고자 한다.Therefore, in the present invention, by using a natural material that has been used as a herbal medicine for a long time, to provide an ointment with less side effects even when used for a long time.

본 발명에서는 오랜 검증기간을 거친 천연성분인 한약재를 사용함으로써 장기간 사용하더라도 부작용이 없는 아토피성피부 개선용 연고를 제공하고자 한다. The present invention is to provide an ointment for improving atopic skin without side effects even by using for a long time by using a herbal medicine that is a natural ingredient that has been through a long verification period.

상기 과제를 해결하기 위하여 본 발명에서는 참기름, 석밀, 돈지, 당귀, 백선피, 백급, 산자고, 자초, 유황, 황토, 사상자 성분을 포함하는 연고를 제공한다.In order to solve the above problems, the present invention provides an ointment including sesame oil, stone wheat, larch, donkey, ringworm, white wheat, sanja high, turmeric, sulfur, ocher, casualty component.

본 발명에 따른 아토피성피부 개선용 연고는 구체적으로 참기름 100중량부에 대하여, 석밀 10~20중량부, 돈지 0.5~1.5중량부, 당귀 3~7중량부, 백선피 3~7중량부, 백급 3~7중량부, 산자고 3~7중량부, 자초 3~7중량부, 유황 3~7중량부, 황토 3~7중량부, 사상자 3~7중량부를 이용하여 제조한다.Ointment for improving atopic dermatitis according to the present invention specifically with respect to 100 parts by weight of sesame oil, 10 to 20 parts by weight, 0.5 to 1.5 parts by weight of larch, donkey 3 to 7 parts by weight, ringworm skin 3 to 7 parts by weight, platinum It is prepared using 3-7 parts by weight, 3-7 parts by weight of acid, 3-7 parts by weight of licorice, 3-7 parts by weight of sulfur, 3-7 parts by weight of ocher, and 3-7 parts by weight of casualties.

본 발명에 사용되는 약재들의 한방에서의 용도를 살펴보면, 참기름(마유)은 성질은 차고 해독효과가 좋으며 능히 모든 병을 제거하는데 부족함이 없는 재료이고, 석밀(석청)은 맛은 달고 성질은 평범하며 불에 달여 익히면 건조한 것은 윤택하게 해주고 독을 풀어주며 인체의 내부를 보호해 주는데 속효가 있고, 주로 곪은 피로 된 아증과 태가 동요하면서 흘러내리는 혈증을 치료하는데 사용되는 재료이며, 돈지(돼지기름)는 주로 종기와 악창에 쓰이고, 독을 죽이는 재료로 사용된다.Looking at the use of herbal medicines used in the present invention, sesame oil (horse oil) is a cold and detoxification effect is good enough to remove all the disease, and not enough to remove all of the bottle, quarry wheat (quartz) taste is sweet and the nature is ordinary When cooked on fire, the dry one is effective for nourishing, releasing poison, and protecting the inside of the human body.It is mainly used for treating tired children and the blood flowing with the womb. Primarily used for boils and spears, it is used as a poison killing material.

당귀(승검초뿌리)는 성질은 따스하고 맛은 달고 매우며 피를 생산하고 심장 을 보호하며 허한 것을 보할 뿐 아니라 체내의 나쁜 피를 축출하는 재료이고, 백선피(검화뿌리)는 성질은 차고 맛은 쓰며 독소에 의한 피부병인 옴과 황달 및 수족마비중에 효과가 크고 피부병과 종창약으로 많이 쓰이는 재료이다.Dongguk (seunggeumchoroot) is warm and sweet and tastes very much. It produces blood, protects the heart, and shows the vulnerable, and extracts bad blood from the body. It is used in skin diseases caused by toxins such as scabies, jaundice, and hand and foot, and is widely used as skin disease and swelling medicine.

백급(대암풀)은 성질은 평탄하고 약간 차며 맛은 쓰고 종독과 헤어진 종창을 치료하는 것으로 주로 외과약으로 쓰이는 재료이고, 산자고(가채무릇)은 맛은 맵고 쓰며 약간 독이 있고 독창과 종기, 두드러기 등의 피부병과 뱀에 물린 독을 제거하는 재료이다.Baekpyeong (large grass) is flat, slightly cold, taste is bitter and heals the swelling and splitting swelling. It is mainly used as a medicine for medicine. Sanjago is spicy, bitter and slightly venomous. It is a material that removes skin diseases and snake bites.

자초(주치)는 성질은 차고 맛은 쓰며 인체의 아홉 구멍을 소통하고 수분을 잘 빠지게 해주며 창만과 마진을 다스리고 종기나 습진에 쓰이는 재료이다.It is a material used for boils and eczema. It is cold and tastes, communicates with nine holes in the human body, helps to drain moisture, and manages swelling and margins.

유황(석류황)은 성질은 뜨겁고 독이 있으며 옴과 종창을 치료하고 냉하고 차가운 기운을 몰아내어 양기를 보하는 재료이고, 황토는 성질은 평범하고 맛을 달며 설사와 이증 및 열로 인한 독을 치료하고, 고기로 인한 중독이나 버섯의 독을 풀어주는 재료이며, 사상자(배암도라지씨)는성질은 따스하고 맛은 약간 맵고 쓰며 기를 상쾌하게 내려주고 내부를 따뜻하게 해주며 풍을 제거하고 체내의 나쁜 피를 없애며 종창, 옴 따위의 가려운 피부병을 치료하는 재료이다.Sulfur (pomegranate) is hot and poisonous, it cures scabies and swelling, and removes cold and cold energy to give yang, and ocher is ordinary and tasteful to treat diarrhea, diarrhea and heat poison. It is a material that releases poison from meat and mushrooms, and the casualty (baeamdoraji) is warm in nature and tastes slightly spicy and bitter, refreshes the body, warms the inside, removes the wind and removes bad blood from the body. It is used to treat itchy skin such as swelling and scabies.

본 발명에서는 상기 약재 중 당귀, 백선피, 백급, 산자고, 자초, 사상자는 건조된 형태의 재료를 사용하고, 유황과 황토는 건조분말 형태를 사용하며, 참기름 100중량부에 대하여 석밀 10~20중량부, 돈지 0.5~1.5중량부, 당귀 3~7중량부, 백선피 3~7중량부, 백급 3~7중량부, 산자고 3~7중량부, 자초 3~7중량부, 유황 3~7중량 부, 황토 3~7중량부, 사상자 3~7중량부를 사용하여 제조한다.In the present invention, the Angelica gigas, ringworm skin, baekryeok, sanjago, vinegar, casualties use the dried form material, sulfur and ocher use the dry powder form, 10 ~ 20 weight of wheat flour with respect to 100 parts by weight of sesame oil Wealth, larch 0.5-1.5 parts by weight, Angelica 3-7 parts by weight, white pine skin 3-7 parts by weight, white grater 3-7 parts by weight, live algae 3-7 parts by weight, licorice 3-7 parts by weight, sulfur 3-7 parts by weight Part, prepared using 3 to 7 parts by weight of ocher, 3 to 7 parts by weight of casualties.

본 발명에 따른 연고의 제조방법을 설명하면, 참기름과 석밀, 돈지를 혼합하고 끓을 때까지 가열하다가, 가열을 지속하면서 당귀, 백선피를 첨가하고, 4~6분 후에 백급, 산자고를 첨가한 후, 4~6분 후에 자초를 첨가한 다음, 2~3분 후에 유황, 황토, 사상자를 첨가한 후, 2~3분 후에 가열을 멈추고, 체로 걸러 약재 건더기를 제거한 다음, 상온에서 서서히 식혀 굳힘으로써 본 발명의 연고를 제조한다. When explaining the manufacturing method of the ointment according to the present invention, while mixing the sesame oil, stone wheat, laurel and heating until boiling, while adding heating, Angelica, ringworm skin is added, and after 4-6 minutes after adding the baekryeok, Sanjago After 4-6 minutes, add the vinegar, and after 2-3 minutes add sulfur, ocher and casualty, stop heating after 2 to 3 minutes, remove the medicinal dry matter by sieving, and then cool slowly at room temperature. The ointment of the present invention is prepared.

본 발명의 연고를 제조함에 있어서, 상기 혼합비나 시간 등의 조건이 절대적인 것은 아니나, 이를 크게 벗어날 경우 질감이 연고로 사용하기에 적합하지 못하거나 그 약효가 떨어질 수 있으므로 상기 범위를 벗어나지 않는 것이 바람직하다.In the preparation of the ointment of the present invention, the conditions such as the mixing ratio or time is not absolute, but if it greatly deviates from the texture is not suitable for use as an ointment or the drug efficacy may fall, it is preferable not to go out of the above range.

본 발명에 따른 연고는 한약재로 사용되어온 천연성분들로 이루어져 장기간 사용시에도 부작용이 발생하지 않으며, 아토피성피부염, 습진, 건선으로 인한 발적, 삼출, 낙설, 가려움증 등의 증상을 개선하는 효과가 있다.Ointment according to the present invention is composed of natural ingredients that have been used as a herbal medicine does not cause side effects even after long-term use, it is effective to improve symptoms such as redness, exudation, itching, itching due to atopic dermatitis, eczema, psoriasis.

본 발명에 따른 아토피성피부 개선용 연고는 한약재로 사용되어온 천연성분들로 이루어져 장기간 사용시에도 부작용이 발생하지 않으며, 아토피성피부염, 습진, 건선으로 인한 발적, 삼출, 낙설, 가려움증 등의 증상을 개선하는 효과가 있다.The ointment for improving atopic dermatitis according to the present invention is composed of natural ingredients that have been used as herbal medicines and does not cause side effects even after long-term use, and improves symptoms such as redness, exudation, abortion, and itching due to atopic dermatitis, eczema and psoriasis. It is effective.

[실시예][Example]

참기름 1000g과 석밀 150g, 돈지 10g을 혼합하고 끓을 때까지 가열하다가, 가열을 지속하면서 당귀 50g, 백선피 50g을 첨가하고, 5분 후에 백급 50g, 산자고 50g을 첨가한 후, 5분 후에 자초 50g을 첨가한 다음, 2분 후에 유황 50g, 황토 50g, 사상자 50g을 첨가한 후, 3분 후에 가열을 중단하였다. 가열을 마친 후, 체로 걸러 약재 건더기를 제거한 다음, 상온에서 서서히 식히면서 굳혀 본 발명에 따른 연고를 제조하였다.Mix 1000 g of sesame oil, 150 g of stone wheat, and 10 g of pork, heat until boiling, add 50g of Angelica and 50 g of white skin while continuing to heat, add 50 g of white ginseng and 50 g of live japonica after 5 minutes, and then add 50 g of sucrose after 5 minutes. After 2 minutes, 50 g of sulfur, 50 g of ocher, and 50 g of casualty were added, and then heating was stopped after 3 minutes. After the heating, the sieve was removed by sieving, and then cooled slowly at room temperature to harden to prepare an ointment according to the present invention.

[시험예][Test Example]

상기 실시예에 따라 제조된 연고를 아토피성피부염 환자 30명의 환부에 30일 동안 1일 2회 도포하도록 한 후 변화를 관찰하였으며, 결과는 표 1에 기재하였다.The ointment prepared according to the above example was applied to the affected area of 30 patients with atopic dermatitis twice a day for 30 days and then the change was observed, and the results are shown in Table 1.

[표 1]TABLE 1

증상정도Symptom level 0일0 days 3일3 days 7일7 days 14일14 days 30일30 days
발적
Redness

심함Severe 2626 1313 33 -- -- 보통usually 44 1313 88 22 -- 약함weakness -- 22 99 1212 88 없음none -- 22 1010 1616 2222
삼출
Effusion

심함Severe 2020 1010 33 -- -- 보통usually 55 1010 55 33 -- 약함weakness 55 88 77 77 22 없음none -- 22 1515 2020 2828
가려움증
Itching

심함Severe 2828 1515 22 -- -- 보통usually 22 1010 1818 77 -- 약함weakness -- 44 99 2020 2020 없음none -- 1One 1One 33 1010

관찰결과, 상당수의 환자가 3일 후부터 가려움증과 삼출, 발적의 증상이 완화되기 시작하였고, 증상의 완화가 나타나는 시기나 완화 정도가 개인에 따라 차이는 있었으나 전반적으로 점차 증상이 개선되었으며, 30일 후에는 발적, 삼출 및 가려움증과 같은 증상이 더 이상 나타나지 않는 환자가 10명에 이르렀다. As a result, many patients began to relieve the symptoms of itching, effusion and redness after 3 days, and the symptoms and the degree of relief were different depending on the individual. There were 10 patients who no longer had symptoms such as redness, effusion and itching.

본 발명에 따른 연고는 백선피, 백급, 산자고, 자초, 유황, 황토, 사상자를 비롯한 피부병 치료에 유용한 한약재 성분을 함유하여, 아토피성피부염의 증상을 완화하는 효과가 있다.Ointment according to the present invention contains a herb ingredient useful for the treatment of skin diseases, including ringworm skin, baekryeok, sanjago, licorice, sulfur, ocher, casualties, has the effect of alleviating the symptoms of atopic dermatitis.

도 1은 본 발명에 따른 아토피성피부 개선용 연고의 제조과정을 나타낸 흐름도이다.1 is a flow chart showing the manufacturing process of the ointment for improving atopic dermatitis according to the present invention.

Claims (2)

삭제delete 참기름 100중량부에 대하여 석밀 15중량부, 돈지 1중량부를 혼합하고 끓을 때까지 가열하다가, 가열을 지속하면서 당귀 5중량부, 백선피 5중량부를 첨가하고, 5분 후에 백급 5중량부, 산자고 5중량부를 첨가한 후, 5분 후에 자초 5중량부를 첨가한 다음, 2분 후에 유황 5중량부, 황토 5중량부, 사상자 5중량부를 첨가한 후, 3분 후 가열을 멈추고 체로 걸러 약재 건더기를 제거한 다음, 상온에서 서서히 식혀 굳히는 방법으로 제조한 것을 특징으로 하는 아토피성피부 개선용 연고.15 parts by weight of wheat flour and 1 part by weight of larch are mixed with 100 parts by weight of sesame oil and heated until boiling, and while heating is continued, 5 parts by weight of Angelica and 5 parts by weight of ringworm skin are added. After adding 5 parts by weight, after 5 minutes, 5 parts by weight of vinegar was added, and after 2 minutes, 5 parts by weight of sulfur, 5 parts by weight of ocher, and 5 parts by weight of casualty were added. Next, ointment for improving atopic dermatitis, which is prepared by the method of cooling and solidifying slowly at room temperature.
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KR20050083465A (en) 2004-02-23 2005-08-26 주식회사 뉴트렉스테크놀러지 Extract of gromwell
KR20060033069A (en) 2004-10-14 2006-04-19 김태균 Herbal bath compositions for the treatment of atopy caused by damp heat and herbal bath bag containing it
KR20070074076A (en) 2006-01-06 2007-07-12 주식회사 티엠바이오텍 Anti-atopic cosmetic composition
KR20080045776A (en) 2006-11-21 2008-05-26 김우원 Process of manufacturing korean bread contining korean medicine

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KR20050083465A (en) 2004-02-23 2005-08-26 주식회사 뉴트렉스테크놀러지 Extract of gromwell
KR20060033069A (en) 2004-10-14 2006-04-19 김태균 Herbal bath compositions for the treatment of atopy caused by damp heat and herbal bath bag containing it
KR20070074076A (en) 2006-01-06 2007-07-12 주식회사 티엠바이오텍 Anti-atopic cosmetic composition
KR20080045776A (en) 2006-11-21 2008-05-26 김우원 Process of manufacturing korean bread contining korean medicine

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