CN107441278A - Pharmaceutical composition, pharmaceutical preparation and its preparation method and application - Google Patents

Pharmaceutical composition, pharmaceutical preparation and its preparation method and application Download PDF

Info

Publication number
CN107441278A
CN107441278A CN201710706721.8A CN201710706721A CN107441278A CN 107441278 A CN107441278 A CN 107441278A CN 201710706721 A CN201710706721 A CN 201710706721A CN 107441278 A CN107441278 A CN 107441278A
Authority
CN
China
Prior art keywords
parts
weight
root
auxiliary material
radix aconiti
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710706721.8A
Other languages
Chinese (zh)
Inventor
丁群
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Tzu Chi Ming Medical Research Institute
Original Assignee
Beijing Tzu Chi Ming Medical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Tzu Chi Ming Medical Research Institute filed Critical Beijing Tzu Chi Ming Medical Research Institute
Priority to CN201710706721.8A priority Critical patent/CN107441278A/en
Publication of CN107441278A publication Critical patent/CN107441278A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888Pinellia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/65Amphibians, e.g. toads, frogs, salamanders or newts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/21Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/51Gentianaceae (Gentian family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/35Extraction with lipophilic solvents, e.g. Hexane or petrol ether

Abstract

The present invention relates to medical technical field, is related to a kind of pharmaceutical composition, pharmaceutical preparation and its preparation method and application.The pharmaceutical composition of the present invention, including Radix Aconiti, Radix Aconiti Kusnezoffii, unprocessed Radix Aconiti Lateralis, dried pinellia, datura flower, arisacma consanguineum schott, Semen Strychni, notopterygium root, levisticum, windproof, rhizoma atractylodis, asarum, the root of Dahurain angelica, Ligusticum wallichii, bark of ash, Chinese cassia tree, the bark of eucommia, the root of bidentate achyranthes, Ramulus Taxilli, the root of herbaceous peony, Chinese ephedra, crotons, lopseed, the seed of garden balsam and dry toad.The present invention has promoting blood circulation and removing blood stasis, dredging the channel, dispelling wind and eliminating dampness, swelling and pain relieving and other effects, quickly it can improve or stimulate circulation, play local anti-inflammatory effect, the symptoms such as pain and the neck, shoulder, waist and leg pain caused by traumatic injury can be released rapidly, there is the therapeutic action of uniqueness to diseases such as cervical spondylopathy, scapulohumeral periarthritis, tennis elbow, lumbar muscle strain, protrusion of lumber intervertebral disc, osteoproliferation, rheumatism, rheumatoids.

Description

Pharmaceutical composition, pharmaceutical preparation and its preparation method and application
Technical field
The present invention relates to medical technical field, more particularly to a kind of pharmaceutical composition, pharmaceutical preparation and its preparation side Method and application.
Background technology
With modern society's working environment, the change of rhythm of life, lack the exercise of appropriateness, wind caused by various factors again The symptoms such as wet, rheumatoid, cervical spondylopathy, scapulohumeral periarthritis, lumbar vertebrae hyperosteogeny, waist dish outstanding or traumatic injury affect the strong of people Health and routine work life, reduce the quality of life of people.
Treatment for above-mentioned disease, regular western medicine treatment are only the disposal of simple wound and symptomatic treatment, can be in short-term Interior alleviation inflammation and pain, often result in local skin stimulation and intestines and stomach side effect, although curative effect is preferable, markedly fast, but It is to cure the symptoms, not the disease, is unsuitable for patient's prolonged application.
The Chinese herbal medicine chosen from Chinese medicine and pharmacology treasure-house, comprehensive promoting blood circulation and removing blood stasis, myogenic pain relieving, anti-inflammation detumescence and other effects, Soft tissue injury can be repaired while inflammation is alleviated.Modern pharmacological research shows that drug for invigorating blood circulation and eliminating stasis can be adjusted entirely Body or local blood circulation, improve blood physicochemical property, suppress inflammatory reaction, regulation immunity of organism etc., from many aspects to above-mentioned Disease is treated at all.But the more existing Chinese medicine composition for alleviating above-mentioned pain also has the effect of certain, but Curative effect is slower, it is impossible to meets the needs of clinical treatment.
So as to, a kind of good analgesic effect is researched and developed, it is quick, there is well promoting blood circulation and removing blood stasis, dredging the channel, disappear Swollen, medicine for relieving pain, has important practical significance.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition, selected plurality of Chinese raw material, scientific compatibility, each original Material cooperates, synergy, is treated both principal and secondary aspect of disease to alleviating the symptoms such as each rheumatoid, cervical spondylopathy, waist dish outstanding, osteoproliferation The effect of.
The second object of the present invention is to provide a kind of pharmaceutical preparation, and the pharmaceutical preparation good analgesic effect is quick, nontoxic Side effect, there is well promoting blood circulation and removing blood stasis, dredging the channel, dispelling wind and eliminating dampness.
The third object of the present invention is to provide a kind of preparation method of pharmaceutical preparation, and this method flow is simple, operation side Just, the effect of each raw material can be given full play to, the invalid components in medicine are reduced, product stability is good.
The fourth object of the present invention is that providing a kind of described pharmaceutical composition or pharmaceutical preparation is preparing with following Application in the medicine of at least one effect:(1) it is promoting blood circulation and removing blood stasis;(2) anti-inflammation detumescence;(3) pain of alleviation.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme:
According to an aspect of the present invention, the present invention provides a kind of pharmaceutical composition, mainly by the raw material of following parts by weight It is made:
10~60 parts of Radix Aconiti, 10~60 parts of Radix Aconiti Kusnezoffii, 10~60 parts of unprocessed Radix Aconiti Lateralis, 5~40 parts of dried pinellia, datura flower 5~ 40 parts, it is 5~40 parts of arisacma consanguineum schott, 30~90 parts of Semen Strychni, 10~60 parts of notopterygium root, 10~60 parts of levisticum, windproof 10~60 parts, grey 10~60 parts of art, 10~60 parts of asarum, 5~50 parts of the root of Dahurain angelica, 5~50 parts of Ligusticum wallichii, 5~50 parts of bark of ash, 5~50 parts of Chinese cassia tree, the bark of eucommia 5 ~50 parts, 5~50 parts of the root of bidentate achyranthes, 5~50 parts of Ramulus Taxilli, 5~50 parts of the root of herbaceous peony, 5~50 parts of Chinese ephedra, 5~50 parts of crotons, lopseed 5 ~50 parts, impetuous 5~50 parts and 2~8 parts of dry toad.
As further preferred technical scheme, described pharmaceutical composition is mainly made up of the raw material of following parts by weight:
20~50 parts of Radix Aconiti, 20~50 parts of Radix Aconiti Kusnezoffii, 20~50 parts of unprocessed Radix Aconiti Lateralis, 10~30 parts of dried pinellia, datura flower 10 ~30 parts, 10~30 parts of arisacma consanguineum schott, 40~80 parts of Semen Strychni, 20~50 parts of notopterygium root, 20~50 parts of levisticum, windproof 20~50 Part, 20~50 parts of rhizoma atractylodis, 20~50 parts of asarum, 10~40 parts of the root of Dahurain angelica, 10~40 parts of Ligusticum wallichii, 10~40 parts of bark of ash, Chinese cassia tree 10~ 40 parts, 10~40 parts of the bark of eucommia, 10~40 parts of the root of bidentate achyranthes, 10~40 parts of Ramulus Taxilli, 10~40 parts of the root of herbaceous peony, 10~40 parts of Chinese ephedra, crotons 10~40 parts, 10~40 parts of lopseed, impetuous 10~40 parts and 3~7 parts of dry toad.
As further preferred technical scheme, described pharmaceutical composition is mainly made up of the raw material of following parts by weight:
30~40 parts of Radix Aconiti, 30~40 parts of Radix Aconiti Kusnezoffii, 30~40 parts of unprocessed Radix Aconiti Lateralis, 15~25 parts of dried pinellia, datura flower 15 ~25 parts, 15~25 parts of arisacma consanguineum schott, 50~60 parts of Semen Strychni, 30~40 parts of notopterygium root, 30~40 parts of levisticum, windproof 30~40 Part, 30~40 parts of rhizoma atractylodis, 30~40 parts of asarum, 20~30 parts of the root of Dahurain angelica, 20~30 parts of Ligusticum wallichii, 20~30 parts of bark of ash, Chinese cassia tree 20~ 30 parts, 20~30 parts of the bark of eucommia, 20~30 parts of the root of bidentate achyranthes, 20~30 parts of Ramulus Taxilli, 20~30 parts of the root of herbaceous peony, 20~30 parts of Chinese ephedra, crotons 20~30 parts, 20~30 parts of lopseed, impetuous 20~30 parts and 4~5 parts of dry toad.
According to another aspect of the present invention, the present invention also provides a kind of pharmaceutical preparation, including above-mentioned pharmaceutical composition And auxiliary material.
As further preferred technical scheme, the auxiliary material includes A groups auxiliary material, B groups auxiliary material and C group auxiliary materials;
Wherein, the A groups auxiliary material includes the parts by weight of sesame oil 1000~6000;
The B groups auxiliary material includes the parts by weight of red lead 800~1800 and the parts by weight of GINKGO BILOBA EXTRACT 500~2000;
The C groups auxiliary material includes the raw net parts by weight of frankincense 3~30, the raw net parts by weight of myrrh 3~30, the weight of Resina Draconis 5~40 Measure part, the parts by weight of castor bean 5~40 and the parts by weight of river centipede 5~30;
Preferably, the A groups auxiliary material includes the parts by weight of sesame oil 2000~4000;
The B groups auxiliary material includes the parts by weight of red lead 1000~1500 and the parts by weight of GINKGO BILOBA EXTRACT 800~1500;
The C groups auxiliary material includes the raw net parts by weight of frankincense 5~20, the raw net parts by weight of myrrh 5~20, the weight of Resina Draconis 10~25 Measure part, the parts by weight of castor bean 10~25 and the parts by weight of river centipede 8~20.
As further preferred technical scheme, the formulation of described pharmaceutical preparation is external preparation;
Preferably, the formulation of described pharmaceutical preparation is emplastrum, ointment, coagulating agent, spray, plastics or put on the skin Agent.
According to another aspect of the present invention, the present invention also provides the preparation method of the pharmaceutical preparation described in more than one, Comprise the following steps:
Above-mentioned pharmaceutical composition and auxiliary material are mixed, stirred, the pharmaceutical preparation is made.
As further preferred technical scheme, comprise the following steps:
Above-mentioned pharmaceutical composition is immersed in A group auxiliary materials 5~10 days, then obtains mixture A;
The mixture A is heated to 90 DEG C~115 DEG C, after removing slag, endured to beading of dripping, adds B group auxiliary materials, is mixed Uniformly, mixture B is obtained;
The mixture B is cooled to 50 DEG C~70 DEG C, C group auxiliary materials is added, is mixed evenly, the medicine is made Preparation.
According to another aspect of the present invention, the present invention also provides a kind of described pharmaceutical composition or described medicine system Application of the agent in the medicine with following at least one effects is prepared:
(1) it is promoting blood circulation and removing blood stasis;
(2) anti-inflammation detumescence;
(3) pain of alleviation.
As further preferred technical scheme, the pain is by rheumatic arthritis, rheumatoid arthritis, hyperostosis Life, Osteoarthritis, cervical spondylopathy, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, lumbar muscle strain, bruises and sprains, soft tissue injury, fracture, frustrate Wound, stiff neck, tenosynovitis, phlebitis, costal chondritis or pain caused by tennis elbow.
Compared with prior art, the beneficial effects of the present invention are:
1st, pharmaceutical composition provided by the invention and pharmaceutical preparation, targetedly reasonable compatibility, with Radix Aconiti, sward The Chinese medicine such as crow, unprocessed Radix Aconiti Lateralis, notopterygium root, levisticum, windproof is raw material, and each raw material components are scientifically arranged in pairs or groups, influenced each other between each component, Synergy is obtained, a kind of safe and effective, medicine for having no toxic side effect, effectively alleviating all kinds of neck-shoulder pain, lumbago and leg pains is provided for people Thing.
2nd, each Chinese medicine material of well-chosen of the present invention, the synergy between medicine is played, reaches promoting blood circulation and removing blood stasis, dredging warp Network, dispelling wind and eliminating dampness, swelling and pain relieving and other effects, quickly it can improve or stimulate circulation, play local anti-inflammatory effect, can be rapid Release the pain and the symptom such as neck, shoulder, waist and leg pain caused by traumatic injury, to cervical spondylopathy, scapulohumeral periarthritis, tennis elbow, lumbar muscle strain, The diseases such as protrusion of lumber intervertebral disc, osteoproliferation, rheumatism, rheumatoid have the therapeutic action of uniqueness.
3rd, the present invention had both avoided some side effects of Western medicine, the defects of overcoming traditional Chinese medicine slow curative effect again, passed through Transdermal absorption, medicine can go directly focus, and good analgesic effect is quick, evident in efficacy, easy to use, drug safety, have important Actual application value.
4th, the preparation method of pharmaceutical preparation provided by the invention, flow is simple, easy to operate, efficiency high, can fully send out The effect of waving each raw material, is effectively retained the nutritional ingredient of each raw material, and reduces the invalid components in medicine, and product stability is good, Safe without toxic side effect, it is easy to industrialized production.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment and embodiment, but this area skill Art personnel will be understood that following embodiments and embodiment are merely to illustrate the present invention, and be not construed as the model of the limitation present invention Enclose.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made Every other embodiment, belongs to the scope of protection of the invention.Unreceipted actual conditions person, builds according to normal condition or manufacturer The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase Product.
In a first aspect, present embodiment provides a kind of pharmaceutical composition, mainly it is made up of the raw material of following parts by weight:
10~60 parts of Radix Aconiti, 10~60 parts of Radix Aconiti Kusnezoffii, 10~60 parts of unprocessed Radix Aconiti Lateralis, 5~40 parts of dried pinellia, datura flower 5~ 40 parts, it is 5~40 parts of arisacma consanguineum schott, 30~90 parts of Semen Strychni, 10~60 parts of notopterygium root, 10~60 parts of levisticum, windproof 10~60 parts, grey 10~60 parts of art, 10~60 parts of asarum, 5~50 parts of the root of Dahurain angelica, 5~50 parts of Ligusticum wallichii, 5~50 parts of bark of ash, 5~50 parts of Chinese cassia tree, the bark of eucommia 5 ~50 parts, 5~50 parts of the root of bidentate achyranthes, 5~50 parts of Ramulus Taxilli, 5~50 parts of the root of herbaceous peony, 5~50 parts of Chinese ephedra, 5~50 parts of crotons, lopseed 5 ~50 parts, impetuous 5~50 parts and 2~8 parts of dry toad.
In the present invention, the effect of each raw material and effect is as follows:
Radix Aconiti:For female root of the ranunculaceae plant Cattell rhizome of Chinese monkshood, acrid flavour, hardship, property heat;The thoughts of returning home, liver,kidney,spleen warp.With dispelling Wind dehumidifies, the effect of antalgic;The illness such as have a pain available for wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, cold hernia.The present invention In, count in parts by weight, the typical but non-limiting content of Radix Aconiti is:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 Part, 45 parts, 50 parts, 55 parts or 60 parts.
Radix Aconiti Kusnezoffii:For the root tuber of the Ranunculaceae herbaceos perennial rhizome of Chinese monkshood (wild species) or the northern rhizome of Chinese monkshood, acrid flavour, hardship, property heat; The thoughts of returning home, liver,kidney,spleen warp.With dispelling wind and eliminating dampness, the effect of antalgic;Available for wind-cold-dampness arthralgia, arthralgia, trusted subordinate's crymodynia, Cold hernia is had a pain, narcotic analgesic.In the present invention, count in parts by weight, the typical but non-limiting content of Radix Aconiti Kusnezoffii is:10 parts, 15 Part, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
Unprocessed Radix Aconiti Lateralis:For the sub- root of the ranunculaceae plant rhizome of Chinese monkshood, acrid flavour, sweet, extremely hot in nature;The thoughts of returning home, kidney, the spleen channel;Rescued with Hui Yang It is inverse, mends fire supporing yang, the effect of eliminating cold to stop pain;Told available for yang depletion collapse, cold weak pulse of limb, deficiency of heart-YANG, chest impediment and cardialgia, the cold of insufficiency type Rush down, coldness and pain in the epigastrium, decline of kidney-YANG, impotence Gong Leng, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, numbness and ache of cold dampness.In the present invention, in parts by weight Meter, the typical but non-limiting content of unprocessed Radix Aconiti Lateralis are:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
Dried pinellia:It is warm-natured for the stem tuber of the Araeceae herbaceos perennial tuber of pinellia, acrid flavour;Returns spleen, stomach, lung channel.Have The effect of eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, swelling and pain relieving, available for abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm Cryogenous headache, vomiting gastric disorder causing nausea, globus hysteriocus etc.;It is to treat the conventional medicine of tumour, it is also often outer to be used to relieve pain, reach the mesh removed obstruction in channels to relieve pain 's.In the present invention, count in parts by weight, the typical but non-limiting content of dried pinellia is:5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts or 40 parts.
Datura flower:Acrid flavour, it is warm-natured;The thoughts of returning home, lung, the spleen channel;With relieving cough and asthma, the effect of calm is relieved pain;Available for asthma Cough, coldness and pain in the epigastrium, arthralgia pain due to rheumatism, infantile chronic fright, or surgical anesthesia.In the present invention, count in parts by weight, datura flower typical case but Nonrestrictive content is:5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 Part, 35 parts, 38 parts or 40 parts.
Arisacma consanguineum schott:It is bitter, pungent, it is warm-natured;With eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, the effect of mass dissipating and swelling eliminating;Available for stupid productive cough Cough, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm, facial paralysis, hemiplegia, epilepsy, infantile convulsion, lockjaw etc..In the present invention, in parts by weight Meter, the typical but non-limiting content of arisacma consanguineum schott are:5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 Part, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts or 40 parts.
Semen Strychni:It is warm-natured for the dry mature seed of loganiaceae plant Strychnos nux-vomica, bitter;Return liver, the spleen channel;With dredging collateral Analgesic, the effect of mass dissipating and swelling eliminating;Available for rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain;Sequelae of infantile paralysis, Rheumatoid arthritis.In the present invention, count in parts by weight, the typical but non-limiting content of Semen Strychni is:30 parts, 35 Part, 40 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts or 90 parts.
Notopterygium root:Acrid flavour, hardship, it is warm-natured;Return bladder, kidney channel;Major function cold dispelling, wind-dispelling, dehumidify, analgesic;Available for chill Cold headache, arthralgia pain due to rheumatism, aching pain in shoulder and back, headache body pain.In the present invention, count in parts by weight, notopterygium root is typical but non-limiting Content be:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
Levisticum:Acrid flavour, hardship, slightly warm in nature.Return liver, kidney, bladder warp;The effect of with expelling wind and eliminating dampness, eliminating cold to stop pain;It can be used for Wind-cold-dampness arthralgia;Lumbocrural pain;Few the moon volt wind headache, headache dentalgia etc., also anti-inflammatory, analgesia and sedation;To platelet aggregation Collection has inhibitory action.In the present invention, count in parts by weight, the typical but non-limiting content of levisticum is:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
It is windproof:Acrid flavour, sweet, slightly warm in nature;Return bladder, lung, spleen, Liver Channel;With expelling pathogenic wind from the body surface, the work(of expel endogenous wind to relieve convulsion, only convulsion Effect;Available for diseases caused by external factors exterior syndrome, rubella itch, arthralgia pain due to rheumatism, lockjaw just, the insufficiency of the spleen with overabundance of dampness.In the present invention, count in parts by weight, Windproof typical but non-limiting content is:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts Or 60 parts.
Rhizoma atractylodis:Acrid flavour, hardship, it is warm-natured;Returns spleen, stomach, Liver Channel;With drying damp and strengthening spleen, expelling wind and clearing away cold, the effect of improving eyesight;It can use Soft powerless, arthralgia pain due to rheumatism, limb in dampness taste, abdominal fullness and distention, cold-dampness leukorrhea, damp-warm diseases and damp invasion of lower energizer, pin swelling and pain in knee, impotence Body arthralgia etc..In the present invention, count in parts by weight, the typical but non-limiting content of rhizoma atractylodis is:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
Asarum:Acrid flavour, it is warm-natured;The thoughts of returning home, lung, kidney channel;With expelling wind and clearing away cold, wind-expelling pain-stopping is sensible, the work(of Wenfei of drink Effect;Available for anemofrigid cold, have a headache, toothache, arthralgia pain due to rheumatism, sputum cough.In the present invention, count in parts by weight, asarum typical case But nonrestrictive content is:10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts.
The root of Dahurain angelica:Acrid flavour, it is warm-natured;Return lung, stomach, large intestine channel.With expelling pathogenic wind from the body surface, eliminating cold to stop pain, dehumidify sensible, detumescence and apocenosis The effect of.Anemofrigid cold is cured mainly, is had a headache, pain in the supra-orbital bone, dentalgia, eye itching lacrimation, nasal obstruction, nasosinusitis, wetness hyperactivity chronic diarrhea, intestines wind anal fistula, Leukorrhea with reddish discharge, ulcer sores, itch mange, venomous snake bite;Also there is the effect such as anti-inflammatory, antipyretic-antalgic, active dissipating bind.The present invention In, count in parts by weight, the typical but non-limiting content of the root of Dahurain angelica is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
Ligusticum wallichii:Acrid flavour, it is warm-natured;Return liver, courage, pericardium channel;With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping;For the obstruction of qi in the chest heart Bitterly, chest side of body shouting pain, tumbling and swelling, irregular menstruation, closed dysmenorrhea, lump in the abdomen lump in the abdomen stomachache, headache, arthralgia pain due to rheumatism.In the present invention, by weight Number meter, the typical but non-limiting content of Ligusticum wallichii are:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts Or 50 parts.
Bark of ash:For Gentianaceae herbaceos perennial, acrid flavour, hardship, cold nature;Return stomach, Liver Channel, gallbladder channel;It is to control rheumatism One of main ingredients of disease such as arthralgia, tuberculosis hectic fever, jaundice, for arthralgia pain due to rheumatism;Energy wind-damp dispelling, relaxing muscles and tendons network, are usually used in rheumatism The diseases such as numbness pain, joint contraction, hands and feet caused by paralysis;Often it is equal in terms of compatibility with windproof, notopterygium root, levisticum, ramulus mori and uses.In the present invention, Count in parts by weight, the typical but non-limiting content of bark of ash is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 Part, 45 parts or 50 parts.
Chinese cassia tree:Acrid flavour, sweet, extremely hot in nature;With complement sun, warming spleen and stomach, removing internal cold, the effect of promoting blood circulation;Ordered available for controlling Door fire declines, cold weak pulse of limb, yang depletion collapse, diarrhea of suffering from abdominal pain, cold hernia run quickly globefish, waist and knee crymodynia, Amenorrhea abdominal mass, cloudy subcutaneous ulcer, streamer, and empty sun It is floating to get over, heat in the upper and cold in the lower.In the present invention, count in parts by weight, the typical but non-limiting content of Chinese cassia tree is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
The bark of eucommia:It is sweet, it is warm-natured;Return liver and kidney channel;With filling liver kidney, strengthening the bones and muscles, it is antiabortive the effect of;Available for kidney deficiency and liver, Soreness of waist and knee joint, muscles and bones is powerless, has a dizzy spell, blood leaking in gestation, fetal irritability.In the present invention, count in parts by weight, the bark of eucommia typical case but Nonrestrictive content is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
The root of bidentate achyranthes:Bitter, acid, it is mild-natured, return liver and kidney channel;With invigorate blood circulation, filling liver kidney, the effect of strengthening the bones and muscles, available for producing After suffer from abdominal pain, irregular menstruation, amenorrhoea, nosebleed epistaxis, toothache caused by fire of deficiency type, tinea pedis oedema, soreness of waist and knee joint, caused by liver and kidney deficiency, bruise stasis caused pain etc..This hair In bright, count in parts by weight, the typical but non-limiting content of the root of bidentate achyranthes is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 Part, 40 parts, 45 parts or 50 parts.
Ramulus Taxilli:It is bitter, sweet, it is mild-natured;Return liver and kidney channel;With wind-damp dispelling, filling liver kidney, strengthening the bones and muscles, antiabortive member and other effects; It is powerless available for arthralgia pain due to rheumatism, soreness and weakness of waist and knees, muscles and bones, fetal irritability, have a dizzy spell.In the present invention, count in parts by weight, mulberry is posted Giving birth to typical but non-limiting content is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
The root of herbaceous peony:Bitter, acid;Cold nature;Return liver, the spleen channel;With soft liver analgesic, nourishing blood for regulating menstruation, astringing YIN to stop sweating, suppressing liver-YANG Function.In the present invention, count in parts by weight, the typical but non-limiting content of the root of herbaceous peony is:5 parts, 10 parts, 15 parts, 20 parts, 25 Part, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
Chinese ephedra:Acrid flavour, slight bitter, it is warm-natured;Return lung, bladder warp;With sweating cold dispelling, freeing lung and relieving asthma, the effect of inducing diuresis for removing edema; Available for catching cold, fever with aversion to cold, head, body pain, nasal obstruction, lossless, the superficies excess syndrome such as floating and tense pulse, and it is uncomfortable in chest breath with cough, geomantic omen Edema, arthralgia pain due to rheumatism, cloudy subcutaneous ulcer, subcutaneous nodule etc..In the present invention, count in parts by weight, the typical but non-limiting content of Chinese ephedra is:5 Part, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
Crotons:Acrid flavour, property heat;The fullness and oppression of chest and abdomen shoot that helps to control caused by cold knot constipation, ascites swelling, cold-evil's dyspepsia, Constipation, dysentery, oedema abdomen is big, phlegm and retained fluid asthma is full, sore-throat larynx numbness, ulcer, malignant sore mange;Available for warm intestines rush down product, by Water dissipate-swelling, place dyspepsia are stagnant and wash away chronic diseases in stomach.In the present invention, count in parts by weight, crotons are typical but non-limit The content of property processed is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
Lopseed:It is sweet, pungent, it is warm-natured;Return lung, Liver Channel;And have the effect of promoting blood circulation and removing blood stasis, diuresis removing toxic substances, stimulate the menstrual flow it is deep; Poison rash etc. available for dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution.In the present invention, count in parts by weight, lopseed typical case But nonrestrictive content is:5 parts, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
It is impetuous:It is mildly bitter flavor, pungent;It is warm-natured;Returns spleen, Liver Channel;The effect of with internal heat anticance, scattered silt detumescence;Available for breaking Blood softening hard masses, disperse accumulations, Amenorrhea, dysphagic etc..In the present invention, count in parts by weight, impetuous typical but non-limiting content is:5 Part, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts or 50 parts.
Dry toad:It is to treat the conventional medicine of tumour, it is also often outer to be used to relieve pain, there is reducing phlegm and resolving masses, the work(of swelling and pain relieving Effect, can change the turbid heresy of channels phlegm, reach the purpose removed obstruction in channels to relieve pain.In the present invention, count in parts by weight, dry toad is typical but non-limit The content of property processed is:2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts.
The pharmaceutical composition that present embodiment provides, targetedly reasonable compatibility, with Radix Aconiti, Radix Aconiti Kusnezoffii, unprocessed Radix Aconiti Lateralis, The Chinese medicine such as notopterygium root, levisticum, windproof is raw material, and each raw material components are scientifically arranged in pairs or groups, influenced each other between each component, obtains collaboration and makees With, for people provide it is a kind of safely and effectively, the medicine that has no toxic side effect, effectively alleviate all kinds of neck-shoulder pain, lumbago and leg pains, to cervical spondylopathy, The diseases such as scapulohumeral periarthritis, tennis elbow, lumbar muscle strain, protrusion of lumber intervertebral disc, osteoproliferation, rheumatism, rheumatoid have the therapeutic action of uniqueness.
In addition, when aforementioned pharmaceutical compositions are using above-mentioned raw material composition and proportioning, the effect of being not simple be added and It is chemiluminescence, influencing each other between various composition, complements each other in described pharmaceutical composition, and synergy is more It is good, it can provide for patient and more fully support, can more embody the drug effect value of above-mentioned raw materials.
Further, the pharmaceutical composition is mainly made up of the raw material of following parts by weight:
20~50 parts of Radix Aconiti, 20~50 parts of Radix Aconiti Kusnezoffii, 20~50 parts of unprocessed Radix Aconiti Lateralis, 10~30 parts of dried pinellia, datura flower 10 ~30 parts, 10~30 parts of arisacma consanguineum schott, 40~80 parts of Semen Strychni, 20~50 parts of notopterygium root, 20~50 parts of levisticum, windproof 20~50 Part, 20~50 parts of rhizoma atractylodis, 20~50 parts of asarum, 10~40 parts of the root of Dahurain angelica, 10~40 parts of Ligusticum wallichii, 10~40 parts of bark of ash, Chinese cassia tree 10~ 40 parts, 10~40 parts of the bark of eucommia, 10~40 parts of the root of bidentate achyranthes, 10~40 parts of Ramulus Taxilli, 10~40 parts of the root of herbaceous peony, 10~40 parts of Chinese ephedra, crotons 10~40 parts, 10~40 parts of lopseed, impetuous 10~40 parts and 3~7 parts of dry toad.
Further, the pharmaceutical composition is mainly made up of the raw material of following parts by weight:
30~40 parts of Radix Aconiti, 30~40 parts of Radix Aconiti Kusnezoffii, 30~40 parts of unprocessed Radix Aconiti Lateralis, 15~25 parts of dried pinellia, datura flower 15 ~25 parts, 15~25 parts of arisacma consanguineum schott, 50~60 parts of Semen Strychni, 30~40 parts of notopterygium root, 30~40 parts of levisticum, windproof 30~40 Part, 30~40 parts of rhizoma atractylodis, 30~40 parts of asarum, 20~30 parts of the root of Dahurain angelica, 20~30 parts of Ligusticum wallichii, 20~30 parts of bark of ash, Chinese cassia tree 20~ 30 parts, 20~30 parts of the bark of eucommia, 20~30 parts of the root of bidentate achyranthes, 20~30 parts of Ramulus Taxilli, 20~30 parts of the root of herbaceous peony, 20~30 parts of Chinese ephedra, crotons 20~30 parts, 20~30 parts of lopseed, impetuous 20~30 parts and 4~5 parts of dry toad.
By the proportioning between each raw material of Reasonable adjustment, the coordinated effect between each raw material is given full play to, is improved The treatment curative effect of pharmaceutical composition, good analgesic effect, for alleviating all kinds of neck-shoulder pain, lumbago and leg pains, regulation recovers total balance of the body, reaches Stable health status has significant effect.
Second aspect, present embodiment provide a kind of pharmaceutical preparation, including above-mentioned pharmaceutical composition and auxiliary material.
When needs, can also be added in aforementioned pharmaceutical compositions one or more pharmaceutically acceptable carriers or Auxiliary material, such as the diluent of pharmaceutical field routine, excipient, filler, wetting agent etc..
The pharmaceutical preparation that present embodiment provides, each Chinese medicine material of well-chosen, the synergy between medicine is played, is reached Promoting blood circulation and removing blood stasis, dredging the channel, dispelling wind and eliminating dampness, swelling and pain relieving and other effects, quickly it can improve or stimulate circulation, play part Antiinflammatory action, the symptoms such as pain and neck, shoulder, waist and leg pain caused by traumatic injury can be released rapidly, to cervical spondylopathy, scapulohumeral periarthritis, The diseases such as tennis elbow, lumbar muscle strain, protrusion of lumber intervertebral disc, osteoproliferation, rheumatism, rheumatoid have the therapeutic action of uniqueness.
In a kind of optional embodiment, the auxiliary material includes A groups auxiliary material, B groups auxiliary material and C group auxiliary materials;
Wherein, the A groups auxiliary material includes the parts by weight of sesame oil 1000~6000;
The B groups auxiliary material includes the parts by weight of red lead 800~1800 and the parts by weight of GINKGO BILOBA EXTRACT 500~2000;
The C groups auxiliary material includes the raw net parts by weight of frankincense 3~30, the raw net parts by weight of myrrh 3~30, the weight of Resina Draconis 5~40 Measure part, the parts by weight of castor bean 5~40 and the parts by weight of river centipede 5~30.
Wherein, the effect of raw material in B groups auxiliary material and C group auxiliary materials and effect is as follows:
Red lead:Also known as red lead is lead orthoplumbate, to be mainly used to treat bleb, prickly heat etc.;Bacterium can directly be killed, posted It is infested, also prevent the effect of mucous secretion.In the present invention, count in parts by weight, the typical but non-limiting content in red lead is: 800 parts, 900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts or 1800 parts.
GINKGO BILOBA EXTRACT:It is ginkgo biloba p.e, there is antibacterial action.It can increase cerebrovascular flow, improve the cerebrovascular and follow Ring function, brain cell is protected, coronary artery dilator, prevents angina pectoris and miocardial infarction, prevent thrombosis, improve immunity of organism Ability.In the present invention, count in parts by weight, the typical but non-limiting content of GINKGO BILOBA EXTRACT is:500 parts, 600 parts, 700 parts, 800 parts, 900 parts, 1000 parts, 1100 parts, 1200 parts, 1300 parts, 1400 parts, 1500 parts, 1600 parts, 1700 parts, 1800 parts, 1900 parts or 2000 parts.
Raw net frankincense:Or lactogenesis is fragrant, acrid flavour, hardship are warm-natured;The thoughts of returning home, liver, the spleen channel;With regulating the qi flowing in the channels, invigorate blood circulation, analgesic, chase after poison The effect of;Available for qi and blood stagnation, trusted subordinate's pain, ulcerative carbuncle pyogenic infections, traumatic injury, dysmenorrhoea, postpartum blood stasis stabbing pain, muscle arteries and veins contraction, Traumatic injury.In the present invention, count in parts by weight, the raw net typical but non-limiting content of frankincense is:3 parts, 5 parts, 6 parts, 8 Part, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts or 30 parts.
Raw net myrrh:Or Myrrha, acrid flavour, hardship are mild-natured, the thoughts of returning home, liver, the spleen channel;With promoting blood circulation and stopping pain, scattered stasis pain, The effect of detumescence and promoting granulation;Available for chest and abdomen stasis caused pain, dysmenorrhoea, Amenorrhea, traumatic injury, carbuncle swells sore, acute appendicitis, red eye, swell pain, postpartum The symptoms such as stasis blocking, arthralgia pain due to rheumatism.In the present invention, count in parts by weight, the raw net typical but non-limiting content of myrrh is:3 parts, 5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts or 30 parts.
Raw net frankincense and raw net myrrh, this two tastes medical instrument have the effect of promoting blood circulation, removing blood stasis and relieving pain, can dispel and block in sick network Extravasated blood, have the function that analgesic.Frankincense and myrrh are clinical herbal pairs, and the promoting blood circulation and stopping pain key medicine that externally applied drug is conventional.
Resina Draconis:It is warm-natured, flat, it is sweet, salty, it is nontoxic, enter blood system, return lung, spleen, kidney three pass through;Stop with promoting blood circulation and removing blood stasis, detumescence Bitterly, astringing to arrest bleeding, softening and resolving hard mass, myogenic sore and other effects;Also having improves body microcirculation, adjustment body metabolism, changes The effects such as kind body's immunity.In the present invention, count in parts by weight, the typical but non-limiting content of Resina Draconis is:5 parts, 6 Part, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts or 40 parts.
Castor bean:For the seed of euphorbia plant castor-oil plant;With detumescence and drawing out poison, led under rushing down it is stagnant, the effect of dredging collateral profit key;Can For swollen ulcer drug, scrofula, acute mastitis, larynx numbness, scabies leprosy tinea sore, scald, oedema turgor, dry feces, facial paralysis, traumatic injury Deng.In the present invention, count in parts by weight, the typical but non-limiting content of castor bean is:5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 32 parts, 35 parts, 38 parts or 40 parts.
River centipede:Acrid flavour, it is warm-natured;Enter Liver Channel;With ceases wind antispastic, dispersing pathogen accumulation, remove obstruction in channels to relieve pain the effect of;Available for only Spasm Spasm, solve the disease such as sore, lockjaw disease, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.In the present invention, count in parts by weight, river The typical but non-limiting content of centipede is:5 parts, 6 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 Part or 30 parts.
River centipede in the present invention is preferably big bar river centipede.
In the present invention, count in parts by weight, the typical but non-limiting content of sesame oil is:1000 parts, 1200 parts, 1500 Part, 1800 parts, 2000 parts, 2200 parts, 2500 parts, 2800 parts, 3000 parts, 3200 parts, 3500 parts, 3800 parts, 4000 parts, 4200 Part, 4500 parts, 4800 parts, 5000 parts, 5200 parts, 5500 parts, 5800 parts or 6000 parts.
The pharmaceutical preparation that present embodiment provides, using aforementioned pharmaceutical compositions as main active, and passes through above-mentioned medicine The mating reaction of compositions and A groups auxiliary material, B groups auxiliary material and C group auxiliary materials, had both avoided some side effects of Western medicine, had overcome again The defects of traditional Chinese medicine slow curative effect, by Transdermal absorption, medicine can go directly focus, and good analgesic effect is quick, curative effect shows Write, easy to use, drug safety, there is important actual application value.
Unless otherwise indicated, in present embodiment each product weight basis all same;For example, pharmaceutical composition, A groups are auxiliary Material, B groups auxiliary material are identical with the weight basis of C group auxiliary materials, are all such as 1 gram.
Further, the A groups auxiliary material includes the parts by weight of sesame oil 2000~4000;
The B groups auxiliary material includes the parts by weight of red lead 1000~1500 and the parts by weight of GINKGO BILOBA EXTRACT 800~1500;
The C groups auxiliary material includes the raw net parts by weight of frankincense 5~20, the raw net parts by weight of myrrh 5~20, the weight of Resina Draconis 10~25 Measure part, the parts by weight of castor bean 10~25 and the parts by weight of river centipede 8~20.
Further, the A groups auxiliary material includes the parts by weight of sesame oil 2500~3500;
The B groups auxiliary material includes the parts by weight of red lead 1200~1400 and the parts by weight of GINKGO BILOBA EXTRACT 1000~1300;
The C groups auxiliary material includes the raw net parts by weight of frankincense 8~15, the raw net parts by weight of myrrh 8~15, the weight of Resina Draconis 12~20 Measure part, the parts by weight of castor bean 12~20 and the parts by weight of river centipede 10~15.
By the proportioning between each raw material in Reasonable adjustment A groups auxiliary material, B groups auxiliary material and C group auxiliary materials, each raw material is given full play to Between coordinated effect, to alleviating the symptoms such as each rheumatoid, cervical spondylopathy, waist dish outstanding, osteoproliferation, to play sample simultaneous The effect of controlling.
In a kind of optional embodiment, the formulation of described pharmaceutical preparation is external preparation;
Preferably, the formulation of described pharmaceutical preparation is emplastrum, ointment, coagulating agent, spray, plastics or put on the skin Agent.
The pharmaceutical preparation that present embodiment provides is existing conventional external preparation, preferably above-mentioned several formulations, but This is not limited to, can also be smears or other formulations;, can by the way of emplastrum or ointment using easy to carry So that medicine, by Transdermal absorption, focus of going directly, good analgesic effect is quick, has no side effect safely.
The third aspect, present embodiment also provide the preparation method of the pharmaceutical preparation described in more than one, including following step Suddenly:
Above-mentioned pharmaceutical composition and auxiliary material are mixed, stirred, the pharmaceutical preparation is made.
The preparation method that present embodiment provides, flow is simple, easy to operate, efficiency high, can give full play to each raw material The effect of, product stability is good, is easy to industrialized production.
It should be noted that after stirring, preparation is carried out according to method commonly used in the prior art, so that emplastrum is made Agent, ointment or coagulating agent etc., you can obtain pharmaceutical preparation.
In a kind of optional embodiment, it the described method comprises the following steps:
Above-mentioned pharmaceutical composition is immersed in A group auxiliary materials 5~10 days, then obtains mixture A;
The mixture A is heated to 90 DEG C~115 DEG C, after removing slag, endured to beading of dripping, adds B group auxiliary materials, is mixed Uniformly, mixture B is obtained;
The mixture B is cooled to 50 DEG C~70 DEG C, C group auxiliary materials is added, is mixed evenly, the medicine is made Preparation.
Preferably, the described method comprises the following steps:
Above-mentioned pharmaceutical composition is immersed in A group auxiliary materials 5~10 days, then obtains mixture A;
The mixture A is heated to 90 DEG C~115 DEG C, when spice is fried to sepia, after removing slag, oil refining, endured to dripping Beading, B group auxiliary materials are added, be well mixed, obtain mixture B;Wherein, the time of oil refining is 3~5 hours;
The mixture B is cooled to 50 DEG C~70 DEG C, C group auxiliary materials is added, is mixed evenly, the medicine is made Preparation;Wherein, C groups auxiliary material is added in the form of fine powder, and the granularity of fine powder is the mesh of 100 mesh~200.
Preferably, the step of methods described also includes releasing fire-toxin, C group auxiliary materials is added, after being mixed evenly, are put it into Soak 7~10 days, release fire-toxin in water;
Ointment after releasing fire-toxin removes water, then is heated to and melts back beach cream, that is, obtains the pharmaceutical preparation.
In a kind of specific embodiment, alternatively, pharmaceutical composition be immersed in time in A group auxiliary materials for 5 days, 6 My god, 7 days, 8 days, 9 days or 10 days.
In a kind of specific embodiment, alternatively, the temperature that mixture A is heated be 90 DEG C, 91 DEG C, 92 DEG C, 93 ℃、94℃、95℃、96℃、97℃、98℃、98℃、99℃、100℃、101℃、102℃、103℃、104℃、105℃、106 DEG C, 107 DEG C, 108 DEG C, 109 DEG C, 110 DEG C, 111 DEG C, 112 DEG C, 113 DEG C, 114 DEG C or 115 DEG C.The time of oil refining be 3 hours, 3.5 hours, 4 hours, 4.5 hours or 5 hours.
In a kind of specific embodiment, alternatively, the temperature that mixture B is cooled down be 50 DEG C, 52 DEG C, 55 DEG C, 58 DEG C, 60 DEG C, 62 DEG C, 65 DEG C, 68 DEG C or 70 DEG C.
So, by the mode of operation of above-mentioned immersion, heating, cooling and mixing etc., each raw material can be effectively retained Nutritional ingredient, the nutrient loss of product is few, and product stability is good, safe without toxic side effect, the pharmaceutical preparation being prepared Good analgesic effect, it is evident in efficacy.
The third aspect, present embodiment provide a kind of above-mentioned pharmaceutical composition or pharmaceutical preparation prepare have it is following extremely Application in a kind of few medicine of effect:(1) it is promoting blood circulation and removing blood stasis;(2) anti-inflammation detumescence;(3) pain of alleviation.
In a kind of optional embodiment, the pain is by rheumatic arthritis, rheumatoid arthritis, hyperostosis Life, Osteoarthritis, cervical spondylopathy, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, lumbar muscle strain, bruises and sprains, soft tissue injury, fracture, frustrate Wound, stiff neck, tenosynovitis, phlebitis, costal chondritis or pain caused by tennis elbow.
The pharmaceutical composition or pharmaceutical preparation that present embodiment is provided are applied has promoting blood circulation and removing blood stasis, anti-inflammation detumescence in preparation And/or in the medicine of pain of alleviation effect, it is easy to use, unnecessary side effect will not be brought to body, good analgesic effect, is treated Effect is notable.
With reference to specific embodiment and comparative example, the invention will be further described.
Embodiment 1
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
10 parts of Radix Aconiti, 10 parts of Radix Aconiti Kusnezoffii, 10 parts of unprocessed Radix Aconiti Lateralis, 5 parts of dried pinellia, 5 parts of datura flower, 5 parts of arisacma consanguineum schott, raw Strychnos nux-vomica Son 30 parts, 10 parts of notopterygium root, 10 parts of levisticum, windproof 10 parts, 10 parts of rhizoma atractylodis, 10 parts of asarum, 5 parts of the root of Dahurain angelica, 5 parts of Ligusticum wallichii, 5 parts of bark of ash, 5 parts of Chinese cassia tree, 5 parts of the bark of eucommia, 5 parts of the root of bidentate achyranthes, 5 parts of Ramulus Taxilli, 5 parts of the root of herbaceous peony, 5 parts of Chinese ephedra, 5 parts of crotons, 5 parts of lopseed, 5 parts of the seed of garden balsam With dry 2 parts of toad;
Count in parts by weight, A groups auxiliary material includes the parts by weight of sesame oil 2000;B groups auxiliary material includes 1000 parts of red lead and ginkgo 800 parts of flavones;C groups auxiliary material includes raw net 5 parts of frankincense, raw net 5 parts of myrrh, 10 parts of Resina Draconis, 10 parts of castor bean and river centipede 8 Part.
Embodiment 2
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
60 parts of Radix Aconiti, 60 parts of Radix Aconiti Kusnezoffii, 60 parts of unprocessed Radix Aconiti Lateralis, 40 parts of dried pinellia, 40 parts of datura flower, 40 parts of arisacma consanguineum schott, life 90 parts of vomiting nut, 60 parts of notopterygium root, 60 parts of levisticum, windproof 60 parts, 60 parts of rhizoma atractylodis, 60 parts of asarum, 50 parts of the root of Dahurain angelica, 50 parts of Ligusticum wallichii, the Qin It is 50 parts of Macrophylla, 50 parts of Chinese cassia tree, 50 parts of the bark of eucommia, 50 parts of the root of bidentate achyranthes, 50 parts of Ramulus Taxilli, 50 parts of the root of herbaceous peony, 50 parts of Chinese ephedra, 50 parts of crotons, deep 50 parts of grass, impetuous 50 parts and 8 parts of dry toad;
Count in parts by weight, A groups auxiliary material includes the parts by weight of sesame oil 6000;B groups auxiliary material includes 1800 parts of red lead and ginkgo 2000 parts of flavones;C groups auxiliary material includes raw net 30 parts of frankincense, raw net 30 parts of myrrh, 40 parts of Resina Draconis, 40 parts of castor bean and river centipede 30 parts.
Embodiment 3
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
50 parts of Radix Aconiti, 50 parts of Radix Aconiti Kusnezoffii, 50 parts of unprocessed Radix Aconiti Lateralis, 30 parts of dried pinellia, 30 parts of datura flower, 30 parts of arisacma consanguineum schott, life 80 parts of vomiting nut, 50 parts of notopterygium root, 50 parts of levisticum, windproof 50 parts, 50 parts of rhizoma atractylodis, 20 parts of asarum, 10 parts of the root of Dahurain angelica, 10 parts of Ligusticum wallichii, the Qin It is 10 parts of Macrophylla, 10 parts of Chinese cassia tree, 10 parts of the bark of eucommia, 10 parts of the root of bidentate achyranthes, 10 parts of Ramulus Taxilli, 10 parts of the root of herbaceous peony, 10 parts of Chinese ephedra, 10 parts of crotons, deep 10 parts of grass, impetuous 10 parts and 5 parts of dry toad;
Count in parts by weight, A groups auxiliary material includes the parts by weight of sesame oil 2000;B groups auxiliary material includes 1000 parts of red lead and ginkgo 800 parts of flavones;C groups auxiliary material includes raw net 20 parts of frankincense, raw net 5 parts of myrrh, 10 parts of Resina Draconis, 10 parts of castor bean and river centipede 10 Part.
Embodiment 4
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
20 parts of Radix Aconiti, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of unprocessed Radix Aconiti Lateralis, 12 parts of dried pinellia, 12 parts of datura flower, 12 parts of arisacma consanguineum schott, life 45 parts of vomiting nut, 25 parts of notopterygium root, 25 parts of levisticum, windproof 25 parts, 25 parts of rhizoma atractylodis, 25 parts of asarum, 25 parts of the root of Dahurain angelica, 30 parts of Ligusticum wallichii, the Qin It is 30 parts of Macrophylla, 15 parts of Chinese cassia tree, 15 parts of the bark of eucommia, 15 parts of the root of bidentate achyranthes, 15 parts of Ramulus Taxilli, 15 parts of the root of herbaceous peony, 20 parts of Chinese ephedra, 20 parts of crotons, deep 20 parts of grass, impetuous 20 parts and 4 parts of dry toad;
A groups auxiliary material, B groups auxiliary material and C group auxiliary materials are same as Example 3.
Embodiment 5
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
32 parts of Radix Aconiti, 32 parts of Radix Aconiti Kusnezoffii, 32 parts of unprocessed Radix Aconiti Lateralis, 24 parts of dried pinellia, 24 parts of datura flower, 24 parts of arisacma consanguineum schott, life 50 parts of vomiting nut, 30 parts of notopterygium root, 30 parts of levisticum, windproof 30 parts, 30 parts of rhizoma atractylodis, 15 parts of asarum, 8 parts of the root of Dahurain angelica, 8 parts of Ligusticum wallichii, bark of ash 8 Part, 8 parts of Chinese cassia tree, 8 parts of the bark of eucommia, 8 parts of the root of bidentate achyranthes, 8 parts of Ramulus Taxilli, 8 parts of the root of herbaceous peony, 8 parts of Chinese ephedra, 8 parts of crotons, 8 parts of lopseed, the seed of garden balsam 8 parts and dry 3 parts of toad;
A groups auxiliary material, B groups auxiliary material and C group auxiliary materials are same as Example 3.
Embodiment 6
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition It is same as Example 3;
Count in parts by weight, A groups auxiliary material includes the parts by weight of sesame oil 3500;B groups auxiliary material includes 1500 parts of red lead and ginkgo 1000 parts of flavones;C groups auxiliary material includes raw net 25 parts of frankincense, raw net 6 parts of myrrh, 12 parts of Resina Draconis, 12 parts of castor bean and river centipede 12 parts.
The preparation method of pharmaceutical preparation described in embodiment 1-6, comprises the following steps:
(a) pharmaceutical composition is immersed in A group auxiliary materials 7 days by formula ratio, then obtains mixture A;
(b) mixture A is heated to 100 DEG C, when spice is fried to sepia, after removing slag, refined oil 4 hours, endured to dripping into Pearl, the B group auxiliary materials of formula ratio are added, be well mixed, obtain mixture B;
(c) when mixture B being cooled into 60 DEG C, the C group auxiliary materials of the form of fine powder are added, the granularity of fine powder is 120 mesh, After being mixed evenly, put it into water and soak 7 days, release fire-toxin;Ointment after releasing fire-toxin removes water, then is heated to thawing Back beach cream, that is, obtain the pharmaceutical preparation.
Embodiment 7
The preparation method of pharmaceutical preparation described in embodiment 3, comprises the following steps:
(a) pharmaceutical composition is immersed in A group auxiliary materials 10 days by formula ratio, then obtains mixture A;
(b) mixture A is heated to 110 DEG C, when spice is fried to sepia, after removing slag, refined oil 3 hours, endured to dripping into Pearl, the B group auxiliary materials of formula ratio are added, be well mixed, obtain mixture B;
(c) when mixture B being cooled into 70 DEG C, the C group auxiliary materials of the form of fine powder are added, the granularity of fine powder is 180 mesh, After being mixed evenly, put it into water and soak 8 days, release fire-toxin;Ointment after releasing fire-toxin removes water, then is heated to thawing Back beach cream, that is, obtain the pharmaceutical preparation.
Comparative example 1
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition In do not include windproof and asarum, other are same as Example 3.
Comparative example 2
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition In do not include lopseed, other are same as Example 3.
Comparative example 3
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition In also include the parts by weight of the root of kudzu vine 20, other are same as Example 3.
Comparative example 4
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, B groups auxiliary material does not wrap GINKGO BILOBA EXTRACT is included, other are same as Example 3.
Comparative example 5
A kind of pharmaceutical preparation, including pharmaceutical composition, A groups auxiliary material, B groups auxiliary material and C group auxiliary materials.Wherein, pharmaceutical composition Mainly it is made up of the raw material of following parts by weight:
80 parts of Radix Aconiti, 80 parts of Radix Aconiti Kusnezoffii, 80 parts of unprocessed Radix Aconiti Lateralis, 45 parts of dried pinellia, 50 parts of datura flower, 45 parts of arisacma consanguineum schott, life 95 parts of vomiting nut, 65 parts of notopterygium root, 65 parts of levisticum, windproof 70 parts, 70 parts of rhizoma atractylodis, 70 parts of asarum, 65 parts of the root of Dahurain angelica, 70 parts of Ligusticum wallichii, the Qin It is 68 parts of Macrophylla, 66 parts of Chinese cassia tree, 55 parts of the bark of eucommia, 55 parts of the root of bidentate achyranthes, 55 parts of Ramulus Taxilli, 55 parts of the root of herbaceous peony, 55 parts of Chinese ephedra, 55 parts of crotons, deep 55 parts of grass, impetuous 55 parts and 10 parts of dry toad;
Count in parts by weight, A groups auxiliary material includes the parts by weight of sesame oil 7000;B groups auxiliary material includes 2000 parts of red lead and ginkgo 2100 parts of flavones;C groups auxiliary material includes raw net 35 parts of frankincense, raw net 35 parts of myrrh, 50 parts of Resina Draconis, 50 parts of castor bean and river centipede 40 parts.
Comparative example 6
It is a kind of in the prior art that there is promoting blood circulation and removing blood stasis, swelling and pain relieving, the pharmaceutical preparation of wind-expelling and cold-expelling efficacy, using by Jilin The unblocking collaterals to treat arthritis patch of Wan Tong medicine companies group production.
In order to verify that the pharmaceutical preparation that embodiment 1-6 and comparative example 1-6 is provided stops in promoting blood circulation and removing blood stasis, dredging the channel, detumescence The effect of pain etc., following clinical test is carried out.Choose 1200 patients, M-F 1:1, average age 40 years old, with Machine is divided into 12 groups, and every group 100, without any treatment 1000 in 1200 patients, Zeng Hangzhen moxibustions, medication, physiotherapy etc. are controlled The treatment person of being not improved 200.
Test method:Cleaning skin, said medicine preparation paste is sticked to affected part, sore place, cover preservative film or special With film, after about 40 minutes, remove;Once, a course for the treatment of is 21 days to one day patch, result of the test is observed and recorded, such as the institute of table 1 Show.
The embodiment 1-6 of table 1 and comparative example 1-6 result of the test
Standard declaration is as follows:Healing refers to that health takes a turn for the better, and is wholly absent phenomena such as joint, swelling pain, joint can Normal freely activity;Effectively refer to that health has taken a turn for the better, alleviated phenomena such as joint, myalgia;It is invalid to refer to body Body situation is not taken a turn for the better, and medicine is not had an effect.
As shown in Table 1, embodiment 1-6 therapeutic effect is substantially better than comparative example 1-6, especially embodiment 3 and embodiment 5 The pharmaceutical preparation provided, more preferably, effective percentage reaches 100% to therapeutic effect.Thus explanation uses the pharmaceutical preparation of the present invention, Human physiological functions can be promoted, to alleviate and treat cervical spondylopathy, scapulohumeral periarthritis, tennis elbow, lumbar muscle strain, protrusion of lumber intervertebral disc, The diseases such as osteoproliferation, rheumatism, rheumatoid have remarkable result.
From the comparative analysis of comparative example 1-5 and embodiment 3, change the proportioning of each raw material in pharmaceutical preparation so that former The proportioning of material either deletes any one raw material or plurality of raw materials or increase is unnecessary not in the scope of protection of the invention Raw material, the effect above can not be realized, it is poor for the effect of alleviating and treat all kinds of neck, shoulder, waist and leg pain.
From the comparative analysis of comparative example 6 and embodiment 3, using pharmaceutical preparation provided by the invention, for all kinds of necks The therapeutic effect of shoulder lumbocrural pain patient is better than existing common drug treatment effect, meanwhile, medicine system provided by the invention Agent has no toxic side effect, drug safety, easy to use, evident in efficacy, can more meet the needs of patient.
Typical case:
1st, Tong Nvshi, 61 years old, people from Chongqing, arteriosclerosis and obstruction of lower limbs inconvenient walking for many years, leg extensions was unfavorable, uninterruptedly treat it is prolonged not More, in March, 2016 releases pain after one week using pharmaceutical preparation provided by the invention, and using being returned to one's perfect health after two weeks, legs and feet are bent Stretch freely, follow-up is not recurred so far.
2nd, Mr. Li, 56 years old, people from Sichuan, osteoproliferation 9 years, with giddy, dizziness, garter uninterruptedly is beaten between 9 years, And often recurrence, make its agonizing, disappear in July, 2016 using using pain after pharmaceutical preparation provided by the invention one week Remove, then continue to basic rehabilitation after using one week, be completely eliminated using symptom after a course for the treatment of, follow-up is not recurred so far.
3rd, Mrs Ding, 26 years old, people from Hubei, specialist of breeding fish, being confined in childbirth to have a cold caused sequelae, trembled with fear pain for many years, used A variety of plaster, stick not bitterly, do not paste and pain, and frequent allergy, use pharmaceutical preparation provided by the invention one week within 2 months 2016 Pain eliminates afterwards, is continuing with after one week no longer pain, follow-up is not recurred so far.
4th, Mr. Gu, 36 years old, people from Henan, Wushu enthusiast, often there is traumatic injury phenomenon, use medicine provided by the invention Thing preparation can swell clearly after one week to disappear bitterly, promoting blood circulation and removing blood stasis, symptom mitigation, after a course for the treatment of, clinical symptom disappearance, and follow-up half Year does not recur.
Finally it should be noted that:Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations;To the greatest extent The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that:Its according to The technical scheme described in foregoing embodiments can so be modified, either which part or all technical characteristic are entered Row equivalent substitution;And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme.

Claims (10)

1. a kind of pharmaceutical composition, it is characterised in that be mainly made up of the raw material of following parts by weight:
10~60 parts of Radix Aconiti, 10~60 parts of Radix Aconiti Kusnezoffii, 10~60 parts of unprocessed Radix Aconiti Lateralis, 5~40 parts of dried pinellia, 5~40 parts of datura flower, 5~40 parts of arisacma consanguineum schott, 30~90 parts of Semen Strychni, 10~60 parts of notopterygium root, 10~60 parts of levisticum, windproof 10~60 parts, rhizoma atractylodis 10 ~60 parts, 10~60 parts of asarum, 5~50 parts of the root of Dahurain angelica, 5~50 parts of Ligusticum wallichii, 5~50 parts of bark of ash, 5~50 parts of Chinese cassia tree, the bark of eucommia 5~50 Part, 5~50 parts of the root of bidentate achyranthes, 5~50 parts of Ramulus Taxilli, 5~50 parts of the root of herbaceous peony, 5~50 parts of Chinese ephedra, 5~50 parts of crotons, lopseed 5~50 Part, impetuous 5~50 parts and 2~8 parts of dry toad.
2. pharmaceutical composition according to claim 1, it is characterised in that be mainly made up of the raw material of following parts by weight:
20~50 parts of Radix Aconiti, 20~50 parts of Radix Aconiti Kusnezoffii, 20~50 parts of unprocessed Radix Aconiti Lateralis, 10~30 parts of dried pinellia, datura flower 10~30 It is part, 10~30 parts of arisacma consanguineum schott, 40~80 parts of Semen Strychni, 20~50 parts of notopterygium root, 20~50 parts of levisticum, windproof 20~50 parts, grey 20~50 parts of art, 20~50 parts of asarum, 10~40 parts of the root of Dahurain angelica, 10~40 parts of Ligusticum wallichii, 10~40 parts of bark of ash, 10~40 parts of Chinese cassia tree, 10~40 parts of the bark of eucommia, 10~40 parts of the root of bidentate achyranthes, 10~40 parts of Ramulus Taxilli, 10~40 parts of the root of herbaceous peony, 10~40 parts of Chinese ephedra, crotons 10~40 Part, 10~40 parts of lopseed, impetuous 10~40 parts and 3~7 parts of dry toad.
3. pharmaceutical composition according to claim 1, it is characterised in that be mainly made up of the raw material of following parts by weight:
30~40 parts of Radix Aconiti, 30~40 parts of Radix Aconiti Kusnezoffii, 30~40 parts of unprocessed Radix Aconiti Lateralis, 15~25 parts of dried pinellia, datura flower 15~25 It is part, 15~25 parts of arisacma consanguineum schott, 50~60 parts of Semen Strychni, 30~40 parts of notopterygium root, 30~40 parts of levisticum, windproof 30~40 parts, grey 30~40 parts of art, 30~40 parts of asarum, 20~30 parts of the root of Dahurain angelica, 20~30 parts of Ligusticum wallichii, 20~30 parts of bark of ash, 20~30 parts of Chinese cassia tree, 20~30 parts of the bark of eucommia, 20~30 parts of the root of bidentate achyranthes, 20~30 parts of Ramulus Taxilli, 20~30 parts of the root of herbaceous peony, 20~30 parts of Chinese ephedra, crotons 20~30 Part, 20~30 parts of lopseed, impetuous 20~30 parts and 4~5 parts of dry toad.
4. a kind of pharmaceutical preparation, it is characterised in that including the pharmaceutical composition and auxiliary material described in any one of claims 1 to 3.
5. pharmaceutical preparation according to claim 4, it is characterised in that the auxiliary material includes A groups auxiliary material, B groups auxiliary material and C groups Auxiliary material;
Wherein, the A groups auxiliary material includes the parts by weight of sesame oil 1000~6000;
The B groups auxiliary material includes the parts by weight of red lead 800~1800 and the parts by weight of GINKGO BILOBA EXTRACT 500~2000;
The C groups auxiliary material include the raw net parts by weight of frankincense 3~30, the raw net parts by weight of myrrh 3~30, the parts by weight of Resina Draconis 5~40, The parts by weight of castor bean 5~40 and the parts by weight of river centipede 5~30;
Preferably, the A groups auxiliary material includes the parts by weight of sesame oil 2000~4000;
The B groups auxiliary material includes the parts by weight of red lead 1000~1500 and the parts by weight of GINKGO BILOBA EXTRACT 800~1500;
The C groups auxiliary material includes the raw net parts by weight of frankincense 5~20, the raw net parts by weight of myrrh 5~20, the weight of Resina Draconis 10~25 Part, the parts by weight of castor bean 10~25 and the parts by weight of river centipede 8~20.
6. the pharmaceutical preparation according to claim 4 or 5, it is characterised in that the formulation of described pharmaceutical preparation is external application system Agent;
Preferably, the formulation of described pharmaceutical preparation is emplastrum, ointment, coagulating agent, spray, plastics or liniment.
7. the preparation method of the pharmaceutical preparation as described in any one of claim 4~6, it is characterised in that comprise the following steps:
Pharmaceutical composition described in any one of claims 1 to 3 and auxiliary material are mixed, stirred, the pharmaceutical preparation is made.
8. the preparation method of pharmaceutical preparation as claimed in claim 5, it is characterised in that comprise the following steps:
Pharmaceutical composition described in any one of claims 1 to 3 is immersed in A group auxiliary materials 5~10 days, then obtains mixture A;
The mixture A is heated to 90 DEG C~115 DEG C, after removing slag, endured to beading of dripping, adds B group auxiliary materials, mixing is equal It is even, obtain mixture B;
The mixture B is cooled to 50 DEG C~70 DEG C, C group auxiliary materials is added, is mixed evenly, the medicine system is made Agent.
9. the medicine system any one of pharmaceutical composition according to any one of claims 1 to 3 or claim 4~6 Application of the agent in the medicine with following at least one effects is prepared:
(1) it is promoting blood circulation and removing blood stasis;
(2) anti-inflammation detumescence;
(3) pain of alleviation.
10. application according to claim 9, it is characterised in that:The pain is by rheumatic arthritis, rheumatoid pass Save inflammation, osteoproliferation, Osteoarthritis, cervical spondylopathy, scapulohumeral periarthritis, protrusion of lumber intervertebral disc, lumbar muscle strain, bruises and sprains, soft tissue Damage, fracture, contusion, stiff neck, tenosynovitis, phlebitis, costal chondritis or pain caused by tennis elbow.
CN201710706721.8A 2017-08-17 2017-08-17 Pharmaceutical composition, pharmaceutical preparation and its preparation method and application Pending CN107441278A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710706721.8A CN107441278A (en) 2017-08-17 2017-08-17 Pharmaceutical composition, pharmaceutical preparation and its preparation method and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710706721.8A CN107441278A (en) 2017-08-17 2017-08-17 Pharmaceutical composition, pharmaceutical preparation and its preparation method and application

Publications (1)

Publication Number Publication Date
CN107441278A true CN107441278A (en) 2017-12-08

Family

ID=60492689

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710706721.8A Pending CN107441278A (en) 2017-08-17 2017-08-17 Pharmaceutical composition, pharmaceutical preparation and its preparation method and application

Country Status (1)

Country Link
CN (1) CN107441278A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110141606A (en) * 2019-06-27 2019-08-20 眉山市中医医院(眉山市东坡区人民医院) A kind of Chinese medicine compound prescription for treating the cold-dampness type protrasion of the lumbar intervertebral disci

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105560748A (en) * 2016-01-23 2016-05-11 唐圣兵 Toxin drawing-out cream and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105560748A (en) * 2016-01-23 2016-05-11 唐圣兵 Toxin drawing-out cream and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110141606A (en) * 2019-06-27 2019-08-20 眉山市中医医院(眉山市东坡区人民医院) A kind of Chinese medicine compound prescription for treating the cold-dampness type protrasion of the lumbar intervertebral disci

Similar Documents

Publication Publication Date Title
CN101601796A (en) The herbal fumigation compositions and the priming thereof of treatment arthromyodynia
CN104721548B (en) A kind of Chinese medicine foodcare washing lotion and preparation method thereof
CN102008674B (en) Plaster for treating herniated disk, hyperosteogeny and rheumatoid diseases and preparation method thereof
CN107441278A (en) Pharmaceutical composition, pharmaceutical preparation and its preparation method and application
CN101773654B (en) Herbal paste for treatment of femoral head necrosis and manufacturing process thereof
CN103191384B (en) Medicament for treating talalgia and preparation method thereof
CN105561270A (en) Analgesic Chinese herbal medicine for external application and preparation method thereof
CN102671180B (en) Medicine for treating rheumatic lumbago and preparation method thereof
CN103550471A (en) Traditional Chinese medicine (TCM) composition for treating Bi pain
CN106853240A (en) It is a kind of effectively to treat external application decoction medicine of osteopathy and preparation method thereof
CN105535869A (en) Traditional Chinese medicine composition capable of effectively treating dysphagia and preparation method thereof
CN105497817A (en) Chinese herbal preparation for treating turgescence caused by trauma of ankle joint and preparation method thereof
CN105497518A (en) Traditional Chinese medicine care solution for soaking feet and preparation method of traditional Chinese medicine care solution
CN105362944A (en) Traditional Chinese medicine ointment for treating orthopedics sprain and contusion
CN104689183A (en) Medicinal liquor with swelling eliminating and blood stasis dispersing functions and preparing method thereof
CN105363005A (en) Kadsura root-bark traditional Chinese medicinal wine
CN105561272A (en) Traditional Chinese medicine preparation for relieving Reynolds disease and preparation method thereof
CN104524454A (en) Tinospora sinensis pain-relieving tincture
CN104127765A (en) Drops for treating skin tinea and preparation method thereof
CN102614433B (en) Traditional Chinese medicine fumigation-washing composition for treating bone fracture and using method thereof
CN108096485A (en) A kind of decoction medicine having a headache for treatment and preparation method thereof
CN108245564A (en) A kind of black plaster and preparation method thereof
CN107158154A (en) It is a kind of to treat time medicine external preparation of rheumatism and preparation method thereof
CN108403860A (en) A kind of Chinese medicine composition with promoting blood circulation antihypertensive effect
CN107115444A (en) A kind of Chinese medicine preparation and preparation method for being used to treat numbness in hands and feet

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20171208

RJ01 Rejection of invention patent application after publication