CN108721503A - One kind is for anti-infectious drug of postoperative wound and preparation method thereof - Google Patents
One kind is for anti-infectious drug of postoperative wound and preparation method thereof Download PDFInfo
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- CN108721503A CN108721503A CN201810961044.9A CN201810961044A CN108721503A CN 108721503 A CN108721503 A CN 108721503A CN 201810961044 A CN201810961044 A CN 201810961044A CN 108721503 A CN108721503 A CN 108721503A
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Abstract
The invention discloses one kind for anti-infectious drug of postoperative wound and preparation method thereof, belongs to pharmaceutical technology field, is made of the ingredient of following parts by weight：15-20 parts of purpleback murdannia herb extract, 10-15 parts of Cortex Magnoliae Officinalis, 8-12 parts of Cortex Phellodendri, 5-10 parts of peppermint oil, 2-5 parts of crystal violet, 5-8 parts of indigo naturalis, 16-19 parts of linseed oil, 8-11 parts of citric acid, 35-42 parts of absolute ethyl alcohol.Anti-infectious drug prepared by the present invention can effectively inhibit the generation of bacteriotoxin, reduce the infection rate of postoperative wound, while alleviate They hurt pain, make wound healing, reduce the generation of scar, spray is made, convenient to take convenient for preserving and carrying.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to one kind being used for the anti-infectious drug of postoperative wound and its preparation side
Method.
Background technology
The infection that nosocomial infection includes the infection that patient occurs during being hospitalized and occurs after being left hospital in hospital.Doctor
No matter institute's infection a brings to society and per capita serious harm.Surgery is the field occurred frequently of nosocomial infection, general surgical wounds
Infection is one of most common infection of surgical site infections, and prodigious proportion is occupied in nosocomial infection.Surgery cut infection
Be easy to cause patient wound's poor healing, extend the hospital stays, increase pain and the financial burden of patient, it is serious possibly even
Life danger can be brought.Clinically often reduced in terms of sterile working, hand Postoperative Dressing this these three from Preoperative Method, operation
The infection rate of operative incision.Surgery cut infection is divided into pyogenic infection and specific infection, and pyogenic infection is by generally suppurating
Caused by bacterium, specific infection has special clinical characters caused by special germ.Principle of reatment is the disease of infection to be eliminated
Cause removes fester and slough, increases the anti-infective and repair ability of patient.The drug master of existing clinical treatment surgical infection
If antibiotic medicine and Chinese medicine, the existing traditional Chinese medicine ingredients for treating surgical infection are complicated, it is slower to take effect.
Antibiotic is generated with antipathogen or other work in survival processes by microorganism or high animals and plants
A kind of secondary metabolite of property, can interfere with the function of other cells.As 20th century epoch-making achievement, the hair of antibiotic
The life of countless people is now saved.But take antibiotic and dosage and the course for the treatment of there are certain requirements, Time of Administration should not mistake
Long, effect is poor, toxic side effect is big, or even can not be restored.Because it is abused, variation becomes antibody-resistant bacterium to many strains rapidly, such as
MRSA, superbacteria etc..Over 20 years especially past, the research and development speed of new drug has lagged far behind the appearance of drug tolerant bacteria
Speed.By the research and development of antiseptic, sterilization is realized in the synthesis of key component from inhibition bacterial cell to more and more researchers
Purpose is changed into the virulence of targeted bacteria, that is, inhibits the mechanism for promoting infection, such as inhibits bacterial invasion host, reduces bacterial virulence
The transcription of the factor and expression, the toxicity of weakening bacterial virulence factors.Since virulence factor is not required, the drug-fast bacteria of bacteria live
The mutation of strain may greatly reduce, and wish for the treatment zone of drug resistant bacterial infections disease.Searching can either inhibit bacterium
Growth, but it is the new strategy of the following reply bacterium infection that can inhibit the new drug of bacterium infection.
The patent document of Publication No. CN106110054A discloses a kind of pharmaceutical composition for treating operating rear wound infection
Object and preparation method thereof, the pharmaceutical composition are made of the drug of following parts by weight：Semen armeniacae amarae, motherwort, Radix Ophiopogonis, pawpaw, stone
Calamus, reed root, saururus chinensis, coix seed, Chinese ephedra, perilla seed, desmodium, Spiderflower Seed, radix bupleuri are carried, the techniques such as alcohol extracting by water
It is made.But it is verified, pharmaceutical composition prepared by this method uses pure Chinese medicine formula, and bactericidal effect is poor, to postoperative wound
Treatment of infection effect is undesirable, and wound healing is slow, is unable to fibroblast proliferation, cannot reduce the generation of scar.
The patent document of Publication No. CN107115415A discloses a kind of medicine group of the anti-infective wound healing promoting of detumescence
Object is closed, by 11 kinds of former materials such as radix scutellariae, the coptis, Cortex Phellodendri, rheum officinale, giant knotweed, garden burnet, sophora flower, Asian puccoon, field pennycress, dandelion and borneol
Material is prepared, and medicine source is extensive, of low cost, being capable of anti-inflammation detumescence, promotion wound healing, promotion diabetic wounds, hemorrhoid
Postoperative patient wound healing.But the invention only plays certain effect to the healing of wound, restraining and sterilizing bacteria effect is poor, and
And need after boiling, clean a wound the surface of a wound, is not easy to store, and carries, inconvenient for use.
Invention content
In view of this, the present invention, which provides one kind, being used for anti-infectious drug of postoperative wound and preparation method thereof, it can be effective
The generation for inhibiting bacteriotoxin, reduces the infection rate of postoperative wound, while alleviating They hurt pain, makes wound healing, subtracts
The generation of few scar.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
One kind being used for the anti-infectious drug of postoperative wound, is made of the ingredient of following parts by weight：Purpleback murdannia herb extract 15-20
Part, 10-15 parts of Cortex Magnoliae Officinalis, 8-12 parts of Cortex Phellodendri, 5-10 parts of peppermint oil, 2-5 parts of crystal violet, 5-8 parts of indigo naturalis, 16-19 parts of linseed oil,
8-11 parts of citric acid, 35-42 parts of absolute ethyl alcohol.
Preferably, described one kind being used for the anti-infectious drug of postoperative wound, is made of the ingredient of following parts by weight：Bamboo
16-19 parts of aspidistra extract, 11-14 parts of Cortex Magnoliae Officinalis, 9-11 parts of Cortex Phellodendri, 6-9 parts of peppermint oil, 2.5-4 parts of crystal violet, 5-7 parts of indigo naturalis,
16-18 parts of linseed oil, 8-10 parts of citric acid, 36-40 parts of absolute ethyl alcohol.
Preferably, the extracting method of the purpleback murdannia herb extract is：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1-1.5h that volume fraction is 70-75% is added, then 65-70
DEG C heating and refluxing extraction 4-5h, filtering, obtains filter residue and filtrate one；
S2：Cyclodextrin is dissolved in water, cyclodextrin aqueous solution is formed, the obtained filter residues of step S1 is placed in cyclodextrin aqueous solution,
40-50 DEG C of constant temperature extracts 2-3h, and filtrate two is collected in filtering；
S3：The filtrate one that step S1 is obtained and the filtrate two that step S2 is obtained are mixed, under room temperature, with turning for 200-300r/min
Speed stirring 15-30min, is then concentrated under reduced pressure, obtains purpleback murdannia herb extract.
Preferably, in the extracting method of the purpleback murdannia herb extract, the dosage of each ingredient is：Purpleback murdannia herb 10g, ethanol solution
110-120g, cyclodextrin 8-10g, water 150-180g.
Preferably, the cyclodextrin is one kind in alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin.
Preferably, described one kind is liquid spray for the anti-infectious drug of postoperative wound.
Preferably, a kind of preparation method for the anti-infectious drug of postoperative wound, comprises the steps of：
Step 1：After Cortex Phellodendri is sliced, it is added after the water that weight is 5-6 times of Cortex Phellodendri impregnates 2-3h and takes out, set in pot and fried with slow boiling
It is done to micro-, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, obtain powder；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, crystal violet, linseed oil, lemon
After acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 10-15 times of the mixed liquor, 60-70 DEG C of water-bath item is added
Under part, after the rotating speed stirring 3-4h of 200-300r/min, it is placed in ultrasonic wave and shakes 1-1.5h, filter, collect filtrate, be packed into
Spray bottle is to get spray.
Preferably, in the step 2, the granularity of powder is 80-100 mesh.
Preferably, in the step 3, steam explosion pressure is 1-1.5MPa, and temperature is 120-135 DEG C, time 10-
12min。
Preferably, in the step 5, ultrasonic frequency 30-40kHz.
The beneficial effects of the invention are as follows：
Secondary metabolite-the exotoxin or endotoxin generated during bacteria live is the main reason for causing host's morbidity.
Therefore the generation for inhibiting bacteriotoxin, weakens the toxicity of bacteriotoxin, can effectively slow down the generation of bacterial infective diseases, be
Treat the most direct mode of infectious diseases.
Purpleback murdannia herb has remarkable removing toxic substances curative effect, has the function of antibacterial anti-inflammatory, has with the extract that ethyl alcohol extracts anti-
Oxidation, antibacterial, antibacterium exotoxin activity and other effects, to staphylococcus aureus, bacillus subtilis, Escherichia coli, sramana
Salmonella etc. has preferable bactericidal bacteriostasis, can effectively inhibit the infection of bacterial wound.
It is Cortex Magnoliae Officinalis acrid flavour, warm-natured, have effects that promoting the circulation of qi dampness elimination, warm in pain, relieving asthma, to staphylococcus, streptococcus,
Fusobacterium nucleatum etc. has stronger antibacterial action.Cortex Phellodendri heat-clearing, eliminating dampness, purging intense heat, removing toxic substances control hot dysentery, diarrhea is quenched one's thirst, jaundice, hemorrhoid
Sore, red eye, swell pain, aphthae, sore swollen toxin have good inhibiting effect to Streptococcus mutans, Candida albicans etc..It is thin
Lotus oil has special refrigerant fragrance, anti-inflammatory analgetic to alleviate They hurt pain.
Crystal violet has preferable bactericidal effect, acts synergistically with Cortex Magnoliae Officinalis, Cortex Phellodendri and purpleback murdannia herb extract, can make micro- life
Object enzyme becomes the inactive state of oxidation, plays the role of the sterilization convergence surface of a wound and presses down meanwhile, it is capable to promote wound immediate union
Fibroblast proliferation is made, reduces the formation of scar.
Indigo naturalis has preferable bacteriostasis, and the couroupitine A contained is the active constituent of antidermatosis fungi, to ulotrichy
Sporidiole bacteria, Microsporum gypseum etc. all have a strong inhibitory effect, and are combined with crystal violet, inhibit bacterium, keep wound fast
Speed healing, restrains the surface of a wound.Linseed oil can play the role of inhibiting scar, act synergistically with crystal violet, indigo naturalis, anti-inflammatory, subtract
The generation of few scar.
Citric acid improves surface-active, enhances the dispersibility between each component, maintenance system balance, while there is sterilization to make
With.There is camphor powder refrigerant sense, slight local anaesthesia effect to alleviate They hurt pain, and anti-corrosion acts synergistically with peppermint oil, town
It is bitterly antipruritic.The present invention selects natural camphor powder, the preferably root of camphor tree, dry, branch, is made through refining.Absolute ethyl alcohol is as organic molten
Agent after being diluted, has sterilizing effect.
After the present invention extracts purpleback murdannia herb with ethyl alcohol, filter residue is extracted again with cyclodextrin, active ingredient obtains abundant profit
With being concentrated under reduced pressure after mixing, obtain purpleback murdannia herb extract.Frying after Cortex Phellodendri is impregnated, removing toxic substances fungistatic effect it is more preferable, with Cortex Magnoliae Officinalis,
Indigo naturalis carries out steam explosion broken wall after crushing together, and crude drug cell improves the rate of release of effective ingredient, be conducive to each group after broken wall
/ synergistic effect.Anti-infectious drug prepared by the present invention can effectively inhibit the generation of bacteriotoxin, reduce postoperative wound
The infection rate of mouth, while alleviating They hurt pain, make wound healing, reduce the generation of scar, spray is made, convenient for protecting
It deposits and carries, it is convenient to take.
Specific implementation mode
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below to the skill of the embodiment of the present invention
Art scheme is clearly and completely described.Obviously, described embodiment is a part of the embodiment of the present invention, rather than complete
The embodiment in portion.Based on described the embodiment of the present invention, every other implementation that those of ordinary skill in the art are obtained
Example, shall fall within the protection scope of the present invention.
In 1 embodiment 1 to 6 of table in anti-infectious drug each ingredient content（Part）
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Purpleback murdannia herb extract | 15 | 16 | 17 | 18 | 19 | 20 |
| Cortex Magnoliae Officinalis | 10 | 11 | 12 | 13 | 14 | 15 |
| Cortex Phellodendri | 8 | 9 | 10 | 11 | 11.5 | 12 |
| Peppermint oil | 5 | 6 | 7 | 8 | 9 | 10 |
| Crystal violet | 2 | 3 | 3.5 | 4 | 4.5 | 5 |
| Indigo naturalis | 5 | 6 | 6.5 | 7 | 7.5 | 8 |
| Linseed oil | 16 | 17 | 17.5 | 18 | 18.5 | 19 |
| Citric acid | 8 | 9 | 9.5 | 10 | 10.5 | 11 |
| Absolute ethyl alcohol | 35 | 37 | 38 | 39 | 40 | 42 |
In 2 embodiment 1 to 6 of table in the extraction process of purpleback murdannia herb extract each ingredient dosage（g）
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | |
| Purpleback murdannia herb | 10 | 10 | 10 | 10 | 10 | 10 |
| Ethanol solution | 110 | 112 | 114 | 116 | 118 | 120 |
| Cyclodextrin | 8 | 8 | 9 | 9 | 10 | 10 |
| Water | 150 | 155 | 160 | 170 | 175 | 180 |
Embodiment 1
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract, comprises the steps of：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1.5h that volume fraction is 70% is added, then heats back for 65 DEG C
Stream extraction 5h, filtering obtain filter residue and filtrate one；
S2：Alpha-cyclodextrin is dissolved in water, cyclodextrin aqueous solution is formed, the obtained filter residues of step S1 is placed in cyclodextrin aqueous solution
In, 40 DEG C of constant temperature extract 3h, and filtrate two is collected in filtering；
S3：The filtrate one that step S1 is obtained and the filtrate two that step S2 is obtained are mixed, under room temperature, stirred with the rotating speed of 200r/min
30min is mixed, is then concentrated under reduced pressure, 60~65 DEG C of thickening temperature, vacuum degree -0.06~-0.08Mpa is concentrated into solid content
Content obtains purpleback murdannia herb extract to 18%~20%.
A kind of preparation method for the anti-infectious drug of postoperative wound, comprises the steps of：
Step 1：After Cortex Phellodendri is sliced, it is added after the water that weight is 5 times of Cortex Phellodendri impregnates 3h and takes out, set micro- with being fried with slow fire in pot
Dry, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, powder is obtained, the granularity of powder is 80 mesh；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder, steam explosion pressure is 1MPa,
Temperature is 120 DEG C, time 12min；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, crystal violet, linseed oil, lemon
After acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 10 times of the mixed liquor is added, under 60 DEG C of water bath conditions,
After the rotating speed stirring 4h of 200r/min, it is placed in ultrasonic wave and shakes 1.5h, filter is collected in ultrasonic frequency 40kHz, filtering
Liquid is packed into spray bottle to get spray.
Embodiment 2
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract being used for the anti-infectious medicine of postoperative wound with embodiment 1, described one kind
The preparation method is the same as that of Example 1 for object.
Embodiment 3
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract, comprises the steps of：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1.5h that volume fraction is 72% is added, then heats back for 68 DEG C
Stream extraction 4.5h, filtering obtain filter residue and filtrate one；
S2：Beta-cyclodextrin is dissolved in water, cyclodextrin aqueous solution is formed, the obtained filter residues of step S1 is placed in cyclodextrin aqueous solution
In, 45 DEG C of constant temperature extract 2.5h, and filtrate two is collected in filtering；
S3：The filtrate one that step S1 is obtained and the filtrate two that step S2 is obtained are mixed, under room temperature, stirred with the rotating speed of 250r/min
20min is mixed, is then concentrated under reduced pressure, 60~65 DEG C of thickening temperature, vacuum degree -0.06~-0.08Mpa is concentrated into solid content
Content obtains purpleback murdannia herb extract to 18%~20%.
A kind of preparation method for the anti-infectious drug of postoperative wound, comprises the steps of：
Step 1：It after Cortex Phellodendri is sliced, is added after the water that weight is 6 times of Cortex Phellodendri impregnates 2.5h and takes out, set in pot with being fried with slow fire
Micro- dry, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, powder is obtained, the granularity of powder is 90 mesh；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder, steam explosion pressure is
1.2MPa, temperature are 130 DEG C, time 11min；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, crystal violet, linseed oil, lemon
After acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 12 times of the mixed liquor is added, under 65 DEG C of water bath conditions,
After the rotating speed stirring 3.5h of 250r/min, it is placed in ultrasonic wave and shakes 1.5h, filter is collected in ultrasonic frequency 40kHz, filtering
Liquid is packed into spray bottle to get spray.
Embodiment 4
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract being used for the anti-infectious medicine of postoperative wound with embodiment 3, described one kind
The preparation method of object is the same as embodiment 3.
Embodiment 5
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract, comprises the steps of：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1h that volume fraction is 75% is added, is then heated to reflux for 70 DEG C
4h is extracted, filtering obtains filter residue and filtrate one；
S2：Gamma-cyclodextrin is dissolved in water, cyclodextrin aqueous solution is formed, the obtained filter residues of step S1 is placed in cyclodextrin aqueous solution
In, 50 DEG C of constant temperature extract 2h, and filtrate two is collected in filtering；
S3：The filtrate one that step S1 is obtained and the filtrate two that step S2 is obtained are mixed, under room temperature, stirred with the rotating speed of 300r/min
15min is mixed, is then concentrated under reduced pressure, 60~65 DEG C of thickening temperature, vacuum degree -0.06~-0.08Mpa is concentrated into solid content
Content obtains purpleback murdannia herb extract to 18%~20%.
A kind of preparation method for the anti-infectious drug of postoperative wound, comprises the steps of：
Step 1：After Cortex Phellodendri is sliced, it is added after the water that weight is 6 times of Cortex Phellodendri impregnates 2h and takes out, set micro- with being fried with slow fire in pot
Dry, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, powder is obtained, the granularity of powder is 100 mesh；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder, steam explosion pressure is
1.5MPa, temperature are 135 DEG C, time 10min；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, crystal violet, linseed oil, lemon
After acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 15 times of the mixed liquor is added, under 70 DEG C of water bath conditions,
After the rotating speed stirring 3h of 300r/min, it is placed in ultrasonic wave and shakes 1h, filtrate is collected in ultrasonic frequency 40kHz, filtering,
Spray bottle is packed into get spray.
Embodiment 6
One kind is liquid spray for the anti-infectious drug of postoperative wound, and prepared by the ingredient of parts by weight as shown in Table 1, institute
The dosage for stating each ingredient in the extraction process of purpleback murdannia herb extract is shown in Table 2.
The extracting method of the purpleback murdannia herb extract being used for the anti-infectious medicine of postoperative wound with embodiment 5, described one kind
The preparation method of object is the same as embodiment 5.
Embodiment 7
One kind is liquid spray for the anti-infectious drug of postoperative wound, is made of the ingredient of following parts by weight：Purpleback murdannia herb
17 parts of extract, 12 parts of Cortex Magnoliae Officinalis, 10 parts of Cortex Phellodendri, 4 parts of cow-bezoar, 8 parts of peppermint oil, 3.5 parts of crystal violet, 7 parts of indigo naturalis, linseed oil
17.5 parts, 10 parts of citric acid, 6 parts of camphor powder, 39 parts of absolute ethyl alcohol.
A kind of preparation method for the anti-infectious drug of postoperative wound, comprises the steps of：
Step 1：It after Cortex Phellodendri is sliced, is added after the water that weight is 6 times of Cortex Phellodendri impregnates 2.5h and takes out, set in pot with being fried with slow fire
Micro- dry, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, powder is obtained, the granularity of powder is 90 mesh；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder, steam explosion pressure is
1.2MPa, temperature are 130 DEG C, time 11min；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, camphor powder, crystal violet, flaxseed
After oil, citric acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 12 times of the mixed liquor is added, under 65 DEG C of water bath conditions,
After the rotating speed stirring 3.5h of 250r/min, it is placed in ultrasonic wave and shakes 1.5h, filter is collected in ultrasonic frequency 40kHz, filtering
Liquid is packed into spray bottle to get spray.
The extracting method of the purpleback murdannia herb extract and the content of each ingredient are the same as embodiment 3.
Embodiment 8
One kind is for anti-infectious drug of postoperative wound and preparation method thereof, the same embodiment of content and preparation method of each ingredient
7, but as different from Example 7, in the present embodiment, the parts by weight of camphor powder are 7 parts.
Comparative example 1
One kind is for anti-infectious drug of postoperative wound and preparation method thereof, with embodiment 5, but as different from Example 5, this
Lack crystal violet in comparative example.
Comparative example 2
One kind is for anti-infectious drug of postoperative wound and preparation method thereof, with embodiment 5, but as different from Example 5, this
Lack citric acid in comparative example.
Comparative example 3
One kind is for anti-infectious drug of postoperative wound and preparation method thereof, with embodiment 5, but as different from Example 5, this
Lack purpleback murdannia herb extract in comparative example.
Comparative example 4
One kind is for anti-infectious drug of postoperative wound and preparation method thereof, with embodiment 5, but as different from Example 5, this
The extracting method of purpleback murdannia herb extract is in comparative example：It comprises the steps of：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1h that volume fraction is 75% is added, is then heated to reflux for 70 DEG C
4h is extracted, filtering obtains filter residue and filtrate one；
S2：The filtrate one that step S1 is obtained under room temperature, stirs 15min with the rotating speed of 300r/min, then carries out depressurizing dense
Contracting, 60~65 DEG C of thickening temperature, vacuum degree -0.06~-0.08Mpa are concentrated into solid content to 18%~20%, obtain bamboo
Aspidistra extract.
Effect assessment
Data：The patient 240 that accepts for medical treatment in January, 2017 in June, 2018 is chosen, is randomly divided into 12 groups, every group 20, every group of trouble
Person is in the general information no difference of science of statistics such as age, course of disease.It is standard to select tcm diagnosis wound or the postoperative infection of operation：Limbs
Wound infection, inflammation, fever, suppuration, non-healing wounds after having wound or performing the operation, the clinical conditions such as red, swollen, hot, pain in part
Shape is one or more.Symptom as above, you can make a definite diagnosis.In the object for making a definite diagnosis observation, male 140, women 100, without other
Serious disease, age are -50 years old 20 years old.
Efficacy determination：1. recovery from illness：Wound heals completely, and part is completely disappeared without red, swollen, hot, pain, clinical symptoms.
2. effective：Wound inflammation is relieved, and fever subsides；Redness is festered substantially reduced；Wound grows new meat, and wound is cured
It closes.
3. effectively：Wound inflammation is alleviated.
4. invalid：Wound pain does not subtract, non-healing wounds.
When clinical trial, withdraw other medicines and health nutrient.It takes obtained by above-described embodiment 1-8 and comparative example 1-4
Anti-infectives are observed one month, as a treatment course.Instructions of taking：It is 3-5 times daily, drug is sprayed on wound.
3 therapeutic evaluation result of table
| Group/index | Sum/people | Recovery from illness/people | Effective/people | Effectively/people | In vain | Total effective rate/% |
| Embodiment 1 | 20 | 16 | 4 | 0 | 0 | 100 |
| Embodiment 2 | 20 | 16 | 3 | 1 | 0 | 100 |
| Embodiment 3 | 20 | 18 | 2 | 0 | 0 | 100 |
| Embodiment 4 | 20 | 17 | 3 | 0 | 0 | 100 |
| Embodiment 5 | 20 | 17 | 2 | 1 | 0 | 100 |
| Embodiment 6 | 20 | 17 | 3 | 0 | 0 | 100 |
| Embodiment 7 | 20 | 19 | 1 | 0 | 0 | 100 |
| Embodiment 8 | 20 | 19 | 1 | 0 | 0 | 100 |
| Comparative example 1 | 20 | 12 | 4 | 1 | 3 | 85 |
| Comparative example 2 | 20 | 12 | 2 | 2 | 4 | 80 |
| Comparative example 3 | 20 | 10 | 0 | 2 | 8 | 60 |
| Comparative example 4 | 20 | 11 | 1 | 2 | 6 | 70 |
Table 3 is the results show that the cure rate of the present invention reaches 80% or more, and effective percentage reaches 100%, significant effect.Comparative example 1 is omitted
Crystal violet, comparative example 2 omit citric acid, and technique does not change, but prepared slices of Chinese crude drugs drug effect is decreased obviously, and illustrate each ingredient of the present invention
Between act synergistically, it is notable to make drug effect play；Comparative example 3 lacks purpleback murdannia herb extract, and drug effective percentage is only 60%, is said
Bright purpleback murdannia herb extract plays important antibacterial anti-infection effect；Comparative example 4 does not have in the extraction process of purpleback murdannia herb extract
Filter residue is extracted with cyclodextrin, drug effective percentage is only 70%, illustrates that cyclodextrin can further carry the ingredient in filter residue
It takes, is combined with ethyl alcohol extraction, helps to improve medicinal material bioavilability, improve medical value.
Model case：
Zhang, female, 26 years old, teacher, Nanyang, henan people, there is redness and festers in wound after caesarean operation, pain fever, using this
The drug of inventive embodiments 7 is sprayed onto affected part, and five times a day, wound fever, symptom of festering disappear after 3 days, continue medication 3 days
Afterwards, red and swollen, pain symptom mitigates, and takes out stitches after a week, after 10 days, wound healing is fully recovered after one month, is investigated after 3 months, scar
Softening, color and luster are thin out.
Liu, female, 30 years old, office worker, Nanyang, henan people, there is red and swollen, fever, pain phenomenon in wound after appendicitis operation,
Using the drug of the embodiment of the present invention 8, it is sprayed onto affected part, three times a day, They hurt pain mitigates after 1 day, after continuing medication 3 days,
Red and swollen, pain symptom disappears, and after a week, wound heals completely, and recovery from illness is investigated after 3 months, and scar softening, color and luster is thin out, approaches
Normal skin tone.
Wei, man, 42 years old, worker, Nanyang, henan people, there is redness and festers in wound after fracture operation, and pain fever uses
The drug of the embodiment of the present invention 8 is sprayed onto affected part, and five times a day, wound fever, redness are festered substantially reduced after 2 days, continue to use
After medicine 5 days, inflammation is relieved, and wound grows new meat, takes out stitches after 10 days, fully recovers after one month, is investigated after 3 months, scar softening,
Color and luster is thin out.
Finally illustrate, the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, this field is common
Other modifications or equivalent replacement that technical staff makes technical scheme of the present invention, without departing from technical solution of the present invention
Spirit and scope, be intended to be within the scope of the claims of the invention.
Claims (10)
1. one kind being used for the anti-infectious drug of postoperative wound, it is characterised in that：It is made of the ingredient of following parts by weight：Purpleback murdannia herb
15-20 parts of extract, 10-15 parts of Cortex Magnoliae Officinalis, 8-12 parts of Cortex Phellodendri, 5-10 parts of peppermint oil, 2-5 parts of crystal violet, 5-8 parts of indigo naturalis, flax
16-19 parts of benevolence oil, 8-11 parts of citric acid, 35-42 parts of absolute ethyl alcohol.
2. as described in claim 1 a kind of for the anti-infectious drug of postoperative wound, it is characterised in that：By following parts by weight
Ingredient be made：16-19 parts of purpleback murdannia herb extract, 11-14 parts of Cortex Magnoliae Officinalis, 9-11 parts of Cortex Phellodendri, 6-9 parts of peppermint oil, crystal violet 2.5-4
Part, 5-7 parts of indigo naturalis, 16-18 parts of linseed oil, 8-10 parts of citric acid, 36-40 parts of absolute ethyl alcohol.
3. as claimed in claim 2 a kind of for the anti-infectious drug of postoperative wound, it is characterised in that：The purpleback murdannia herb extraction
The extracting method of object is：
S1：After purpleback murdannia herb drying and crushing, the alcohol solution dipping 1-1.5h that volume fraction is 70-75% is added, then 65-70
DEG C heating and refluxing extraction 4-5h, filtering, obtains filter residue and filtrate one；
S2：Cyclodextrin is dissolved in water, cyclodextrin aqueous solution is formed, the obtained filter residues of step S1 is placed in cyclodextrin aqueous solution,
40-50 DEG C of constant temperature extracts 2-3h, and filtrate two is collected in filtering；
S3：The filtrate one that step S1 is obtained and the filtrate two that step S2 is obtained are mixed, under room temperature, with turning for 200-300r/min
Speed stirring 15-30min, is then concentrated under reduced pressure, obtains purpleback murdannia herb extract.
4. as claimed in claim 3 a kind of for the anti-infectious drug of postoperative wound, it is characterised in that：The purpleback murdannia herb extraction
In the extracting method of object, the dosage of each ingredient is：Purpleback murdannia herb 10g, ethanol solution 110-120g, cyclodextrin 8-10g, water 150-
180g。
5. as claimed in claim 4 a kind of for the anti-infectious drug of postoperative wound, it is characterised in that：The cyclodextrin is α-
One kind in cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin.
6. as claimed in claim 5 a kind of for the anti-infectious drug of postoperative wound, it is characterised in that：Described one kind is used for
The anti-infectious drug of postoperative wound is liquid spray.
7. a kind of preparation method for the anti-infectious drug of postoperative wound as claimed in any one of claims 1 to 6, special
Sign is：It comprises the steps of：
Step 1：After Cortex Phellodendri is sliced, it is added after the water that weight is 5-6 times of Cortex Phellodendri impregnates 2-3h and takes out, set in pot and fried with slow boiling
It is done to micro-, taking-up is dried, and Cortex Phellodendri piece is made；
Step 2：The Cortex Phellodendri piece that Cortex Magnoliae Officinalis, indigo naturalis and step 1 obtain is picked up only, dry, sterilizing after crushing, is stirred with camphor powder
Mixing, it is dry, obtain powder；
Step 3：The powder that step 2 obtains is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder；
Step 4：The steam explosion wall cell disruption powder that step 3 is obtained and purpleback murdannia herb extract, peppermint oil, crystal violet, linseed oil, lemon
After acid, absolute ethyl alcohol and stirring mixing, 3h is stood, mixed liquor is obtained；
Step 5：In the mixed liquor obtained to step 4, the water that weight is 10-15 times of the mixed liquor, 60-70 DEG C of water-bath item is added
Under part, after the rotating speed stirring 3-4h of 200-300r/min, it is placed in ultrasonic wave and shakes 1-1.5h, filter, collect filtrate, be packed into
Spray bottle is to get spray.
8. a kind of preparation method for the anti-infectious drug of postoperative wound as claimed in claim 7, it is characterised in that：It is described
In step 2, the granularity of powder is 80-100 mesh.
9. a kind of preparation method for the anti-infectious drug of postoperative wound as claimed in claim 8, it is characterised in that：It is described
In step 3, steam explosion pressure is 1-1.5MPa, and temperature is 120-135 DEG C, time 10-12min.
10. a kind of preparation method for the anti-infectious drug of postoperative wound as claimed in claim 9, it is characterised in that：Institute
It states in step 5, ultrasonic frequency 30-40kHz.
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