CN109125712A - A kind of burned infants scald anesthesia dressing patch - Google Patents

A kind of burned infants scald anesthesia dressing patch Download PDF

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Publication number
CN109125712A
CN109125712A CN201811126341.8A CN201811126341A CN109125712A CN 109125712 A CN109125712 A CN 109125712A CN 201811126341 A CN201811126341 A CN 201811126341A CN 109125712 A CN109125712 A CN 109125712A
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scald
burned
infants
parts
pharmaceutical preparation
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张新科
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Nanyang City Center Hospital
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Nanyang City Center Hospital
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
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    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

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Abstract

The present invention provides a kind of burned infants scald anesthesia dressing patch; belong to field of medical article technology; outer layer and the protective layer mutually be bonded with the outer layer including being coated with medical viscose glue; the middle part that the outer layer is coated with the one side of the medical viscose glue is equipped with depressed area; dressing layer is set in the depressed area, and the dressing layer is made by gauze and by the pharmaceutical preparation that the gauze wraps up.Good permeability of the present invention, can be effectively antibacterial, can alleviate wound pain after medication, quickly accelerate wound healing, promotes skin cell metabolism, and is suitable for burned infants scald without scar after treatment and uses, significant in efficacy.

Description

A kind of burned infants scald anesthesia dressing patch
Technical field
The present invention relates to field of medical article technology, and in particular to a kind of burned infants scald anesthesia dressing patch.
Background technique
Infant's curiosity is strong, active, is to currently form family's burning often by hot oil, hot liquid scald in kitchen, bathroom The Main victims of wound.Burned infants are mostly since delicate skin is by hydrothermal solution (water, soup, congee, oil, milk), flame, the substances such as electricity Damage.Infant's damaged skin more change dressings of empyrosis need daily or progress in every two days primary, and damaged skin is replaced Pain caused by dressing is the most violent in the pain that burn infant is subjected to.Strong pain bring subsequent reactions are to burn Infant brings different degrees of physical and mental injury, and the process of damaged skin reparation is delayed because more change dressings are resisted, extend by Damage the period required for skin repair；For fear, frightened even post-traumatic stress obstacle, leaves in memory Gloomy shade；In addition, parent needs to take more time to look after after burned infants, the daily work of parent is affected Make, reduces economic results in society.After burned infants or scald, the position of burn or scald is relatively itched, and can not independently be carried out Scratching easily leads to burn or scald site infection, situation is caused further to deteriorate.Therefore, it develops a kind of for burned infants It is most important to scald dedicated anesthesia dressing patch.
The patent document of Publication No. CN107744428A discloses a kind of medical dressing patch, is related to medical supplies technology neck Domain, the invention include the dressing paste layer being stacked from below to up, absorbed layer and are removably adhered on absorbed layer Protective layer, at the outer rim of the dressing paste layer on be coated with adhesive, the middle position of dressing paste layer, institute is arranged in the absorbed layer State protective layer dressing paste layer and absorbed layer is fully wrapped around, the dressing paste layer be hydrophobic, air-permeability profile material, the absorbed layer by The identical upper fixing layer of the cross sectional dimensions being stacked, lower fixing layer and being fixed between fixing layer and lower fixing layer is inhaled It receives interlayer to form, the material of fixed layer and lower fixing layer is grid cloth；The invention has preferable waterproofness and breathes freely Property, but the invention mainly solves the problems, such as that dressing patch water-proof breathable properties are bad, not to the Wound healing and bone regeneration effect of empyrosis Ideal, and analgesic effect is poor.
Notification number is that the patent of CN104436097B discloses a kind of drug for treating burn, including the big xanthorrhiza dried End, the big xanthorrhiza end dried in the shade, borneol end, hydrated lime in powder, alum end, Radix Astragali end, waxgourd peel end, pulp of a pumpkin end, ginger, white wine Equal raw material.The invention also discloses the preparation method and application method of said medicine, and above-mentioned raw material are placed in white wine, It is uniformly mixed, that is, drug is made, and this drug is simply smeared in the use of this drug after burn, and interval is after 2-4 hours Continue to smear drug, until recovery from illness.But it is verified, which cannot effectively facilitate wound healing, and wound restores slower, still Scar can be stayed, and in use, need to smear repeatedly for several times daily, it is very inconvenient.
Summary of the invention
In view of this, the present invention provides a kind of burned infants to scald with dressing patch is anaesthetized, good permeability can be effective It is antibacterial, wound pain can be alleviated after medication, quickly accelerate wound healing, promote skin cell metabolism, and without scar after treatment Trace is suitable for burned infants scald and uses, significant in efficacy.
In order to solve the above technical problems, the technical solution used in the present invention is:
A kind of burned infants scald anesthesia dressing patch, including being coated with the outer layer of medical viscose glue and mutually be bonded with the outer layer Protective layer, the middle part that the outer layer is coated with the one side of the medical viscose glue are equipped with depressed area, dressing layer are arranged in the depressed area, The dressing layer is made by gauze and by the pharmaceutical preparation that the gauze wraps up.
Preferably, the outer layer is cotton fiber or bamboo charcoal fiber.
Preferably, the pharmaceutical preparation is prepared from the following raw materials in parts by weight: 2-4 parts of scorpio, 6-8 parts of beeswax, vegetable seed 15-20 parts oily, 20-28 parts of Common Cissampelos Herb, 2-5 parts of monkshood, 10-15 parts of Radix Glycyrrhizae, 5-8 parts of Moschus, 3-5 parts of dyetree fruit, epidermis are raw Long factor 0.5-0.9 parts, 45-60 parts of physiological saline, 4-10 parts of polyethylene glycol.
Preferably, the beeswax is medical grade beeswax particle.
Preferably, the sodium-chloride water solution that the physiological saline is 0.9%.
Preferably, the preparation method of the pharmaceutical preparation comprises the steps of:
S1: by scorpio in pot after the micro- Huang of frying, smashing is placed in rape seed oil at fine powder, at room temperature with 200-300r/min's It after revolving speed stirs 10-15min, is placed in ultrasonic wave after shaking 3-5h, filtering takes filtrate that beeswax is added, at room temperature with 100- The revolving speed of 200r/min stirs 30-45min, obtains material one；
S2: monkshood and Radix Glycyrrhizae are cleaned, and slice is put into the distilled water of 6-8 times of addition in container, decoct 4-6h, decoction liquor is taken to add Enter in the material one that step S1 is obtained, obtains material two；
S3: Common Cissampelos Herb, Moschus, dyetree fruit are picked up only, dry, and sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion Wall cell disruption powder；
S4: after epidermal growth factor and physiological saline are mixed, polyethylene glycol is added, at room temperature with the revolving speed of 300-400r/min After stirring 5-10min, the steam explosion wall cell disruption powder that step S3 is obtained and the material two that step S2 is obtained is added, adjustment revolving speed is 100- 200r/min dry, pulverize after stirring 45-60min, obtain pharmaceutical preparation.
Preferably, the preparation method of the pharmaceutical preparation, in step S1, ultrasonic frequency 30-40kHz.
Preferably, the preparation method of the pharmaceutical preparation, in step S3, steam explosion pressure is 0.8-1.2MPa, and temperature is 110-130 DEG C, time 10-15min.
Preferably, the granularity of the pharmaceutical preparation is 200-300 mesh.
Preferably, the protective layer is barrier paper.
The beneficial effects of the present invention are: the present invention includes the outer layer for being coated with medical viscose glue and the protection mutually be bonded with outer layer Layer, outer layer be cotton fiber or bamboo charcoal fiber, breathe freely, and stop bacterial invasion, medical viscose glue be medical pressure sensitive adhesive, protective layer be every From paper, outer layer and dressing layer are protected, protect the cementability of medical viscose glue.Outer layer is coated with the middle part of the one side of medical viscose glue Equipped with depressed area, dressing layer is set in depressed area, dressing layer is made by gauze and by the pharmaceutical preparation that the gauze wraps up.It uses When, barrier paper is peelled off, by dressing layer alignment wound bonding.
In pharmaceutical formulations of the present invention, scorpio relieve the wind syndrome antispastic, dispersing pathogen accumulation is removed obstruction in channels to relieve pain, and the present invention subtracts after its frying Slow toxicity, the antibacterial anti-corrosion of beeswax, rapeseed oil moisturize desinsection, detumescence poison.The present invention by scorpio in conjunction with beeswax, rapeseed oil, dissipating bind Wound healing is accelerated in disinfection.
Common Cissampelos Herb returns liver, the spleen channel, bitter, temperature, swelling and pain relieving, hemostasis, myogenic.It swells and ache for wound, wound hemorrhage.
Monkshood analgesic, is equipped with Radix Glycyrrhizae, anti-inflammation detumescence slows down wound pain.
Moschus is pungent, warm, nontoxic, bitter.Enter the heart, spleen, Liver Channel, blood circulation promoting and dispersing pathogen accumulation, alleviating pain and detumescence, have have one's ideas straightened out, ward off it is dirty, logical The function of network, scattered silt.
Dyetree fruit blood gas, analgesic, desinsection are antipruritic.For traumatic injury, arthralgia and myalgia, carbuncle swells, wet sore, scabies etc..
Skin injury, postoperative wound, bedsore, canker sore and gangrene are treated in epidermal growth factor and radiotherapy draws The dermatitis etc. risen.It can accelerate the healing of wound and ulcer surface, promote the metabolism of application on human skin, reduce skin deformity.This The epidermal growth factor that invention is selected is purchased from Sigma company, and the powder of 10nm is less than for partial size, and mass fraction is greater than 99%.It selects After physiological saline solution epidermal growth factor, polyethylene glycol is added, epidermal growth factor is protected, is preferably played medicinal Value.
The present invention is directed to the particularity of infant, and the dressing patch of preparation can effectively treat the burn of infant, scald, make Used time peels off barrier paper, by dressing layer alignment wound bonding, shortens the dressing time, reduces the fear of infant, very Convenient, good permeability can be effectively antibacterial, can alleviate wound pain after medication, quickly accelerate wound healing, promote Skin Cell Metabolism, and without obvious scar after treatment, it is significant in efficacy.
Detailed description of the invention
The present invention is described in further detail with reference to the accompanying drawing.
Fig. 1 is the cross-sectional view of the dressing patch of the embodiment of the present invention 1.
Fig. 2 is the structural schematic diagram of the dressing patch of the embodiment of the present invention 1.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention Attached drawing 1-2, the technical solution of the embodiment of the present invention is clearly and completely described.Obviously, described embodiment is this A part of the embodiment of invention, instead of all the embodiments.Based on described the embodiment of the present invention, the common skill in this field Art personnel every other embodiment obtained, shall fall within the protection scope of the present invention.
In the present invention, in embodiment 1-8, beeswax is medical grade beeswax particle, the aqueous sodium chloride that physiological saline is 0.9% Liquid, epidermal growth factor are purchased from Sigma company, and the powder of 10nm is less than for partial size, and mass fraction is greater than 99%.
The content (part) of 1 embodiment 1-6 pharmaceutical formulations each component of table
Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 Embodiment 5 Embodiment 6
Scorpio 2 2.5 3 3.5 3.8 4
Beeswax 6 6.5 7 7.5 7.7 8
Rapeseed oil 15 16 17 18 19 20
Common Cissampelos Herb 20 22 24 25 26 28
Monkshood 2 2.5 2.8 3 3.5 5
Radix Glycyrrhizae 10 11 12 13 14 15
Moschus 5 5.5 6 7 7.5 8
Dyetree fruit 3 3.3 3.8 4 4.5 5
Epidermal growth factor 0.5 0.6 0.7 0.7 0.8 0.9
Physiological saline 45 48 50 53 56 60
Polyethylene glycol 4 5 6 8 9 10
Embodiment 1
As illustrated in fig. 1 and 2, a kind of burned infants scald anesthesia dressing patch is present embodiments provided, including is coated with medical viscous The outer layer 4 of glue 1 and the protective layer 5 mutually Nian Jie with the outer layer 4, the outer layer 4 are coated with the middle part of the one side of the medical viscose glue 1 Equipped with depressed area 2, dressing layer 3 is set in the depressed area 2, the dressing layer 3 is by gauze and the drug wrapped up by the gauze Preparation is made.The outer layer 4 is cotton fiber, and the protective layer 5 is barrier paper, and the medical viscose glue 1 is medical pressure sensitive adhesive.
The depressed area 2 is ellipse, and the dressing layer 3 is consistent with the shape of depressed area 2, the dressing layer 3 and recess Area 2 passes through medical viscose glue adhesion.
The component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made.
The preparation method of the pharmaceutical preparation comprises the steps of:
S1: by scorpio in pot after the micro- Huang of frying, smashing is placed in rape seed oil at fine powder, at room temperature with the revolving speed of 200r/min It after stirring 15min, is placed in 30kHz ultrasonic wave after shaking 5h, filtering takes filtrate that beeswax is added, at room temperature with 100r/min's Revolving speed stirs 45min, obtains material one；
S2: monkshood and Radix Glycyrrhizae are cleaned, and slice is put into the distilled water of 6 times of addition in container, decocts 4h, take decoction liquor that step is added In the material one that rapid S1 is obtained, material two is obtained；
S3: Common Cissampelos Herb, Moschus, dyetree fruit are picked up only, dry, and sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion Wall cell disruption powder, steam explosion pressure are 0.8MPa, and temperature is 110 DEG C, time 15min；
S4: after epidermal growth factor and physiological saline are mixed, polyethylene glycol is added, is stirred at room temperature with the revolving speed of 300r/min After 10min, the steam explosion wall cell disruption powder that step S3 is obtained and the material two that step S2 is obtained is added, adjustment revolving speed is 100r/min, is stirred It after mixing 60min, dry, pulverize, granularity is 200 mesh, obtains pharmaceutical preparation.
Embodiment 2
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: outer layer is bamboo charcoal fiber in the present embodiment.
The component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made.
The preparation method of the pharmaceutical preparation comprises the steps of:
S1: by scorpio in pot after the micro- Huang of frying, smashing is placed in rape seed oil at fine powder, at room temperature with the revolving speed of 250r/min It after stirring 12min, is placed in 40kHz ultrasonic wave after shaking 4h, filtering takes filtrate that beeswax is added, at room temperature with 150r/min's Revolving speed stirs 40min, obtains material one；
S2: monkshood and Radix Glycyrrhizae are cleaned, and slice is put into the distilled water of 7 times of addition in container, decocts 5h, take decoction liquor that step is added In the material one that rapid S1 is obtained, material two is obtained；
S3: Common Cissampelos Herb, Moschus, dyetree fruit are picked up only, dry, and sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion Wall cell disruption powder, steam explosion pressure are 1MPa, and temperature is 120 DEG C, time 12min；
S4: after epidermal growth factor and physiological saline are mixed, polyethylene glycol is added, is stirred at room temperature with the revolving speed of 350r/min After 8min, the steam explosion wall cell disruption powder that step S3 is obtained and the material two that step S2 is obtained is added, adjustment revolving speed is 150r/min, stirring It after 50min, dry, pulverize, granularity is 300 mesh, obtains pharmaceutical preparation.
Embodiment 3
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into:
The component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made.
The preparation method of the pharmaceutical preparation comprises the steps of:
S1: by scorpio in pot after the micro- Huang of frying, smashing is placed in rape seed oil at fine powder, at room temperature with the revolving speed of 300r/min It after stirring 10min, is placed in 40kHz ultrasonic wave after shaking 3h, filtering takes filtrate that beeswax is added, at room temperature with 200r/min's Revolving speed stirs 30min, obtains material one；
S2: monkshood and Radix Glycyrrhizae are cleaned, and slice is put into the distilled water of 8 times of addition in container, decocts 6h, take decoction liquor that step is added In the material one that rapid S1 is obtained, material two is obtained；
S3: Common Cissampelos Herb, Moschus, dyetree fruit are picked up only, dry, and sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion Wall cell disruption powder, steam explosion pressure are 1.2MPa, and temperature is 130 DEG C, time 10min；
S4: after epidermal growth factor and physiological saline are mixed, polyethylene glycol is added, is stirred at room temperature with the revolving speed of 400r/min After 5min, the steam explosion wall cell disruption powder that step S3 is obtained and the material two that step S2 is obtained is added, adjustment revolving speed is 200r/min, stirring It after 60min, dry, pulverize, granularity is 250 mesh, obtains pharmaceutical preparation.
Embodiment 4
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: the component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made, and the preparation method is the same as that of Example 1 for the pharmaceutical preparation.
Embodiment 5
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: the component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made, and the preparation method of the pharmaceutical preparation is the same as embodiment 2.
Embodiment 6
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: the component of the parts by weight of the pharmaceutical preparation as shown in Table 1 is made, and the preparation method of the pharmaceutical preparation is the same as embodiment 3.
Embodiment 7
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: each component and content increase by 2.5 with embodiment 1, but unlike the first embodiment in the pharmaceutical preparation in the present embodiment Parts by weight it is refined red grand.
The preparation method of the pharmaceutical preparation with embodiment 2, unlike, step S3: by Common Cissampelos Herb, Moschus, Platycarya strobilacea Fruit, it is refined it is red it is grand pick up net, dry, sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion wall cell disruption powder, steam explosion pressure is 1MPa, temperature are 120 DEG C, time 12min.
Embodiment 8
A kind of burned infants scald anesthesia dressing patch is present embodiments provided, is changing of carrying out on the basis of embodiment 1 Into: each component and content are with embodiment 1 in the pharmaceutical preparation, but increase by 3 weights unlike the first embodiment, in the present embodiment Measure the refined red grand of part.
The preparation method of the pharmaceutical preparation is the same as embodiment 7.
Comparative example 1
This comparative example provides a kind of pharmaceutical preparation, in the pharmaceutical preparation each component and content with embodiment 1, but with embodiment 1 Unlike, scorpio, beeswax and rapeseed oil are lacked in this comparative example.The preparation method is the same as that of Example 1 for the pharmaceutical preparation, but with Unlike embodiment 1, this comparative example lacks step S1.
Comparative example 2
This comparative example provides a kind of pharmaceutical preparation, in the pharmaceutical preparation each component and content with embodiment 1, but with embodiment 1 Unlike, Common Cissampelos Herb is omitted in this comparative example.
Comparative example 3
This comparative example provides a kind of pharmaceutical preparation, in the pharmaceutical preparation each component and content with embodiment 1, but with embodiment 1 Unlike, monkshood and Radix Glycyrrhizae are lacked in this comparative example.The preparation method is the same as that of Example 1 for the pharmaceutical preparation, but with embodiment 1 Unlike, this comparative example lacks step S2.
Comparative example 4
This comparative example provides a kind of pharmaceutical preparation, in the pharmaceutical preparation each component and content with embodiment 1, but with embodiment 1 Unlike, surface growth factor, physiological saline and polyethylene glycol are lacked in this comparative example.The preparation method of the pharmaceutical preparation With embodiment 1, but unlike the first embodiment, this comparative example step S4: by the obtained steam explosion wall cell disruption powder of step S3 and step S2 Obtained material two mixes, and adjusting revolving speed at room temperature is that 100r/min dry, pulverize after stirring 60min, and granularity is 200 mesh, Obtain pharmaceutical preparation.
Effect assessment
Data: 0-3 years old infant's burned patient 288 accepted for medical treatment in January, 2016 in December, 2017 are chosen, wherein burn and scald I degree of wound, light degree Ⅱ, deep II degree and III degree each 72 people, are divided into 12 groups, and every group 24, every group of I degree of burn and scald, light degree Ⅱ, II degree of depth With III degree of each 6 people, without other serious diseases.
Burn and scald degree judgment criteria
I degree of burn: lesion is stronger, only damages epidermis, micro- swollen, micro- red, hypodynia.
Light degree Ⅱ burn (also known as blister burn): it is red and swollen obvious, there is bubble not of uniform size to be formed, bubble is cut It is broken.
Deep II degree of burn: local swelling, the surface of a wound is white after removing downright bad skin, insensitive.
III degree of burn: also known as eschar burn, part is pale yellowish-brown, sallow, and serious person is in deeply worried shape or carbonization, skin Skin follows the string, and the surface of a wound is dry, and no sepage is sent out cool, and aculeus indolence is felt.
Treatment method: being affixed on affected part for dressing patch of the invention, and first three days, daily replacement 2 times is daily later to replace 1 time, Observation two weeks, it is as a treatment course.
Curative effect judging standard:
Cure: pain, red and swollen disappearance, skin function restore normal, preventing from scar；
Effective: pain, red and swollen disappearance, skin return to normal, and have scar to leave；
Effective: slightly pain, red and swollen disappearance, skin have certain recovery.
Invalid: the pretherapy and post-treatment state of an illness is unchanged.
2 therapeutic evaluation result of table
Group/index Sum/people Recovery from illness/people Effective/people Effectively/people In vain Total effective rate/%
Embodiment 1 24 14 5 3 2 91.67
Embodiment 2 24 15 5 2 2 91.67
Embodiment 3 24 15 6 2 1 95.83
Embodiment 4 24 14 7 2 1 95.83
Embodiment 5 24 14 8 1 1 95.83
Embodiment 6 24 15 7 1 1 95.83
Embodiment 7 24 18 4 2 0 100.00
Embodiment 8 24 19 3 2 0 100.00
Comparative example 1 24 12 5 3 4 83.33
Comparative example 2 24 13 4 4 3 87.50
Comparative example 3 24 12 6 2 4 83.33
Comparative example 4 24 10 4 4 6 75.00
For table 2 the results show that effective percentage of the invention reaches 91% or more, embodiment 7 and 8 is added to refined red grand, promoting blood circulation to remove blood stasis, fiber crops Liquor-saturated analgesic, hemostasia and promoting granulation, effective percentage reach 100%, significant effect.Comparative example 1 omits scorpio, beeswax and rapeseed oil, comparative example 2 Common Cissampelos Herb is omitted, comparative example 3 lacks monkshood and Radix Glycyrrhizae, and technique has not been changed, but drug effect is decreased obviously, and illustrates each ingredient of the present invention Between act synergistically, so that it is significant to play drug effect；Comparative example 4 lacks surface growth factor, physiological saline and polyethylene glycol, says Bright surface growth factor can effectively rapidly promote wound healing, and polyethylene glycol is added, protects to epidermal growth factor, more Good performance medical value.
Typical case:
Lee, male, 9 months, Nanyang, henan people, hot water scald, light degree Ⅱ burn, wound was red and swollen, there is bubble, cry and screamed more than, After needling, after the dressing patch treatment of the embodiment of the present invention 7, feeling of pain disappears within two days, and child no longer cries and screams, after a week, wound Mouth healing, scar color is thin out, and after 10 days, scar disappears.
Mr. Wang, female, 20 months, Nanyang, henan people, electric burn, III degree of burn, burn surface area 8%, part it is pale it is yellowish-brown, Sallow, serious person is in deeply worried shape or carbonization, and skin follows the string, after the dressing patch treatment of the embodiment of the present invention 8, one week Afterwards, wound healing, wound grow new meat, and after a course for the treatment of, scar color is thin out.
The above is a preferred embodiment of the present invention, it is noted that for those skilled in the art For, without departing from the principles of the present invention, it can also make several improvements and retouch, these improvements and modifications It should be regarded as protection scope of the present invention.

Claims (10)

1. a kind of burned infants scald anesthesia dressing patch, it is characterised in that: including be coated with medical viscose glue outer layer and with institute The protective layer that outer layer is mutually bonded is stated, the middle part that the outer layer is coated with the one side of the medical viscose glue is equipped with depressed area, the recess Dressing layer is set in area, and the dressing layer is made by gauze and by the pharmaceutical preparation that the gauze wraps up.
2. a kind of burned infants scald anesthesia dressing patch as described in claim 1, it is characterised in that: the outer layer is cotton Fiber or bamboo charcoal fiber.
3. a kind of burned infants scald anesthesia dressing patch as claimed in claim 2, it is characterised in that: the pharmaceutical preparation It is prepared from the following raw materials in parts by weight: 2-4 parts of scorpio, 6-8 parts of beeswax, 15-20 parts of rapeseed oil, 20-28 parts of Common Cissampelos Herb, monkshood 2-5 parts, 10-15 parts of Radix Glycyrrhizae, 5-8 parts of Moschus, 3-5 parts of dyetree fruit, 0.5-0.9 parts of epidermal growth factor, physiological saline 45-60 Part, 4-10 parts of polyethylene glycol.
4. a kind of burned infants scald anesthesia dressing patch as claimed in claim 3, it is characterised in that: the beeswax is doctor With grade beeswax particle.
5. a kind of burned infants scald anesthesia dressing patch as claimed in claim 4, it is characterised in that: the physiological saline For 0.9% sodium-chloride water solution.
6. a kind of burned infants scald anesthesia dressing patch as claimed in claim 5, it is characterised in that: the pharmaceutical preparation Preparation method comprise the steps of:
S1: by scorpio in pot after the micro- Huang of frying, smashing is placed in rape seed oil at fine powder, at room temperature with 200-300r/min's It after revolving speed stirs 10-15min, is placed in ultrasonic wave after shaking 3-5h, filtering takes filtrate that beeswax is added, at room temperature with 100- The revolving speed of 200r/min stirs 30-45min, obtains material one；
S2: monkshood and Radix Glycyrrhizae are cleaned, and slice is put into the distilled water of 6-8 times of addition in container, decoct 4-6h, decoction liquor is taken to add Enter in the material one that step S1 is obtained, obtains material two；
S3: Common Cissampelos Herb, Moschus, dyetree fruit are picked up only, dry, and sterilizing after crushing, is put into steam explosion in Steam explosive machine, obtains steam explosion Wall cell disruption powder；
S4: after epidermal growth factor and physiological saline are mixed, polyethylene glycol is added, at room temperature with the revolving speed of 300-400r/min After stirring 5-10min, the steam explosion wall cell disruption powder that step S3 is obtained and the material two that step S2 is obtained is added, adjustment revolving speed is 100- 200r/min dry, pulverize after stirring 45-60min, obtain pharmaceutical preparation.
7. a kind of burned infants scald anesthesia dressing patch as claimed in claim 6, it is characterised in that: the pharmaceutical preparation Preparation method, in step S1, ultrasonic frequency 30-40kHz.
8. a kind of burned infants scald anesthesia dressing patch as claimed in claim 7, it is characterised in that: the pharmaceutical preparation Preparation method, in step S3, steam explosion pressure is 0.8-1.2MPa, and temperature is 110-130 DEG C, time 10-15min.
9. a kind of burned infants scald anesthesia dressing patch as claimed in claim 8, it is characterised in that: the pharmaceutical preparation Granularity be 200-300 mesh.
10. a kind of burned infants scald anesthesia dressing patch as claimed in claim 9, it is characterised in that: the protective layer For barrier paper.
CN201811126341.8A 2018-09-26 2018-09-26 A kind of burned infants scald anesthesia dressing patch Pending CN109125712A (en)

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