CN1743004A - Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof - Google Patents
Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof Download PDFInfo
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- CN1743004A CN1743004A CN 200510108355 CN200510108355A CN1743004A CN 1743004 A CN1743004 A CN 1743004A CN 200510108355 CN200510108355 CN 200510108355 CN 200510108355 A CN200510108355 A CN 200510108355A CN 1743004 A CN1743004 A CN 1743004A
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- compound preparation
- pregnant
- spermicide
- sperm
- gel
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000000934 spermatocidal agent Substances 0.000 claims abstract description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 45
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 41
- HNLXNOZHXNSSPN-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCOCCOCCOCCO)C=C1 HNLXNOZHXNSSPN-UHFFFAOYSA-N 0.000 claims description 29
- 229910052709 silver Inorganic materials 0.000 claims description 25
- 239000004332 silver Substances 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 23
- 229950004053 octoxinol Drugs 0.000 claims description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 17
- 210000001215 vagina Anatomy 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 238000012856 packing Methods 0.000 claims description 15
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 13
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 12
- 229920002125 Sokalan® Polymers 0.000 claims description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 12
- 229960001631 carbomer Drugs 0.000 claims description 12
- 239000002270 dispersing agent Substances 0.000 claims description 12
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 claims description 11
- 229940050929 polyethylene glycol 3350 Drugs 0.000 claims description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 11
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 10
- 239000000178 monomer Substances 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 230000008961 swelling Effects 0.000 claims description 8
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 6
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- NMXDTPBZWZGMMO-UHFFFAOYSA-N 4-(2-methyl-5-propan-2-ylcyclohexyl)phenol Chemical compound C1C(C(C)C)CCC(C)C1C1=CC=C(O)C=C1 NMXDTPBZWZGMMO-UHFFFAOYSA-N 0.000 claims description 5
- -1 alkyl imidazoline Chemical compound 0.000 claims description 5
- 229960001112 menfegol Drugs 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 claims description 4
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 4
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 4
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 4
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 4
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical group CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 claims description 4
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 229930182479 fructoside Natural products 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 229940009188 silver Drugs 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 25
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001150 spermicidal effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 32
- 230000002779 inactivation Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 239000012895 dilution Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 230000002254 contraceptive effect Effects 0.000 description 6
- 230000001568 sexual effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000011550 stock solution Substances 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000003433 contraceptive agent Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 206010006784 Burning sensation Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 229940127234 oral contraceptive Drugs 0.000 description 2
- 239000003539 oral contraceptive agent Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000005659 seminal clot liquefaction Effects 0.000 description 2
- 238000012109 statistical procedure Methods 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229960004418 trolamine Drugs 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 235000007199 Panicum miliaceum Nutrition 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 206010044248 Toxic shock syndrome Diseases 0.000 description 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000022185 broomcorn panic Species 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a compound preparation for bactericidal sterilization and spermicidal contraception and its preparation method. Said compound preparation includes broad-spectrum antimicrobial, spermicide for contraception, water and auxiliary material with pharmaceutical acceptable quantity. Said compound preparation adopts vaginal medication method, so that it is safe and reliable. Said invention also provides the concrete steps of its preparation method.
Description
Technical field
The present invention relates to a kind of compound preparation that is used for anti-pregnancy by killing sperm and sterilizing, specifically relate to a kind of gel that is used for anti-pregnancy by killing sperm and sterilizing and preparation method thereof.
Background technology
The family planning cause is the fundamental state policy of country, to the improvement of family planning apparatus and apparatus with to apply then be to realizing the important technology support of this state basic policy, the family planning apparatus and the apparatus of develop safe, effective, easy, few side effects, help healthy reproduction, the masses taking like a shot are the development trends of family planning product.
Contraceptive device commonly used at present is oral contraceptive, the contraception of external barrier, all there are certain weak point in the use in condom, contraceptive diaphragm, diaphragm, contraception sponge, birth control art, oral contraceptive often has the effect of the endocrine of interference, cause nausea, vomit even the irregular side reaction such as bleed of vagina, limited its scope of application; Condom is to use more men's contraceptive device at present, but anaphylaxis or sense of discomfort can appear in groups of people, and rupture rate is reported in 1%-12% and does not wait, and the slippage rate is 6% in the sexual intercourse; Contraceptive diaphragm is to put into the soft rubber medicated cap that intravaginal is covered in cervix uteri and posterior fornix before a kind of sexual life, but because of diaphragm edge and vaginal wall can not tightly seal, mortality does not wait at 1.6% ￣ 9.8%; Diaphragm is a kind of and the similar barrier rubber contraceptive device of barrier film, and the palpus doctor matches size and and guides application process during application, and mortality is 5%-18%; The contraception sponge is a kind of round and elastic thing piece by the Polyurethane material that contains spermicide, and it has the absorption seminal fluid, and the effect of braking sperm and barrier contraception remains in the report that vagina causes toxic shock syndrome but have because of the vaginal sponge fragment.
Summary of the invention
The object of the present invention is to provide the compound preparation that is used for anti-pregnancy by killing sperm and sterilizing that a kind of contraceptive effect is remarkable, easy to use, toxic and side effects is little.
Another object of the present invention provides the preparation method of a kind of compound preparation that is used for anti-pregnancy by killing sperm and sterilizing and preparation method thereof.
For achieving the above object, the compound preparation that is used for anti-pregnancy by killing sperm and sterilizing provided by the invention comprises the component of stating weight portion:
Broad spectrum antimicrobicide 0.01-50, anti-pregnant spermicide 2-20.
Preferably, comprise following components by part by weight:
Broad spectrum antimicrobicide 15-50, anti-pregnant spermicide 2-20.
Preferably, comprise following components by part by weight:
Broad spectrum antimicrobicide 0.01-0.1, anti-pregnant spermicide 2-20.
Most preferably, described compound preparation also comprises following components by part by weight:
The adjuvant of water 90-750 and medically acceptable amount.
Described broad spectrum antimicrobicide is a kind of or wherein several mixture of nanometer silver, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, triclosan.
Described nanometer silver particle diameter is the 1-100 nanometer.
Described anti-pregnant spermicide is a kind of or wherein several mixture in Octoxinol, nonoxynolum, Alfenoxynol, Menfegol, the benzalkonium chloride.
Described adjuvant is a kind of or wherein several mixture in monomer carrier, surfactant and the dispersant.
The weight part ratio of described adjuvant:
Monomer carrier 15-815 surfactant 50-140 dispersant 45-350;
Described monomer carrier is a kind of or wherein several mixture in carbomer, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), Polyethylene Glycol-400, the Polyethylene Glycol-3350.
Described surfactant is a sodium laurylsulfate, hard ester acid, hard ester alcohol, dodecyl sodium sulfate (AS), sodium lauryl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB), α-monoalkyl glycerin ether (GE), the polyoxyethylene polyoxypropylene copolyether, polyglycereol-polybutylene fatty alcohol ether (PGT alkyl ether), fructoside, butyl stearate, isostearic acid isopropyl alcohol ester, polyvinylpyrrolidone, dodecyl dimethyl sodium acetate (BS-12), alkylamide propyl-betaine, a kind of or wherein several mixture in the alkyl imidazoline.
Described dispersant is a kind of or wherein several mixture in glycerol, propylene glycol, sodium laurylsulfate, the triethanolamine.
Described compound preparation is a gel.
A kind of method for preparing sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation comprises: under normal temperature condition water, monomer carrier, surfactant, dispersant are stirred, add broad spectrum antimicrobicide, resist pregnant spermicide to stir packing.
The another method of preparation sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation, comprise: under normal temperature condition, water, monomer carrier, surfactant, dispersant are stirred, add broad spectrum antimicrobicide, resist pregnant spermicide to stir, under 60-90 ℃ of heating and stirring condition, add hard ester acid and/or hard ester alcohol, mix homogeneously, be cooled under stirring and solidify packing.
A method again of preparation sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation comprises:
Under normal temperature condition, broad spectrum antimicrobicide, anti-pregnant spermicide are dissolved in the water; Carbomer added in the glycerol to grind make moistening and the part swelling, the carbomer swellbility is 40-60%, add entry and make it to absorb the abundant swelling of moisture until being translucent gel, again with the above-mentioned gel of dispersant adding soluble in water, grind well into the transparent gel-type vehicle of stiff, add above-mentioned broad spectrum antimicrobicide, anti-pregnant spermicide solution, grind well, packing gets final product.
Usage and consumption:
Use one before the sexual life.
Tear packing before the use, take out the vaginal administration device that is loaded with the nanometer silver conception control gel;
The protecgulum of vaginal administration device front end is taken off, insert the vagina administration rear end as the boosting bar; Adopt dorsal position, knee bends is opened both legs as far as possible, and the slow ring of vaginal administration device is inserted the vagina depths, promotes to help bar with forefinger, and nanometer silver conception control gel full dose is pushed the depths, slowly extracts out then.
Sterilizing of the present invention and anti-pregnancy by killing sperm vagina administration compound preparation be safe and effective, have contraception, and antibiotic, lubricated effect is easy to use, toxic and side effects is little.Clinical data shows that the agent of compound recipe sterilization conception control gel acts on 2min, 20min under experimental condition, colibacillary bacteriostasis rate is respectively 93.8%, 98.3%; Bacteriostasis rate to staphylococcus aureus is respectively 97.9%, 99.3%; Antibiotic rate to white chain pearl bacterium is 95.0%, 97.2% respectively, and showing has stronger antibacterial action.Compound recipe sterilizes the conception control gel agent under 1: 6 dilution factor, and the sperm inactivation rate reaches 100% in 1 minute; Under 1: 30 dilution factor, the sperm inactivation rate reaches 100% in 1 minute; Under 1: 60 dilution factor, the sperm inactivation rate reaches 79.00 ± 3.92% in 1 minute; The sperm inactivation rate reaches 100% in 5 minutes.Intercept the sperm test and show in 5 seconds sperm inactivation ratio average 100% in average 98.2%, 1 minute of the sperm inactivation ratio.
Other has except the explanation, and the prescription of the anti-pregnant gel of compound recipe sterilization is in the following test:
Nanometer silver 0.1kg Octoxinol 20kg
Polyethylene Glycol-400 90kg glycerol 200kg
Acritamer 940 15g triethanolamine 150g
Sodium laurylsulfate 3.0kg Polyethylene Glycol-3350 50kg
Purified water 471.9kg
Make 1000kg
The antibiotic property test
Antibacterial tests is detected by Guangzhou Disease Prevention-Control Center: carry out according to GB15979-2002 " (disposable use hygienic article sanitary standard " appendix C regulation, result of the test shows: the anti-pregnant gel of compound recipe sterilization acts on 2min, 20min under experimental condition, colibacillary bacteriostasis rate is respectively 93.8%, 98.3%; Bacteriostasis rate to staphylococcus aureus is respectively 97.9%, 99.3%; Antibiotic rate to white chain pearl bacterium is 95.0%, 97.2% respectively; Stronger antibacterial action is arranged.See Table 1.
Test group agents useful for same: the anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization;
The matched group agents useful for same:
Escherichia coli: aseptic sodium chloride-peptone buffer agent+escherichia coli (8099);
Staphylococcus aureus: aseptic sodium chloride-peptone buffer agent+staphylococcus aureus (ATCC6538);
Candida albicans: aseptic sodium chloride-peptone buffer agent+Candida albicans (ATCC10231).
Table 1: antibacterial tests result
| Test strain | Activity | Action time (min) | Test group is deposited viable count meansigma methods (cfu/ml) | Matched group is deposited viable count meansigma methods (cfu/ml) | Bacteriostasis rate (%) |
| Escherichia coli 8099 | Stock solution | 2 5 10 20 | 4.2×103 3.4×103 2.8×103 2.5×103 | 6.8×104 6.9×104 7.2×104 7.8×104 | 93.8 95.1 96.1 98.3 |
| Staphylococcus aureus ATCC6538 | Stock solution | 2 5 10 20 | 1.1×103 0.8×103 0.7×103 0.4×103 | 5.3×104 5.6×104 5.5×104 5.7×104 | 97.9 98.6 98.7 99.3 |
| Candida albicans ATCC10231 | Stock solution | 2 5 10 20 | 2.9×103 2.8×103 1.8×103 1.6×103 | 5.7×104 5.8×104 5.4×104 5.7×104 | 95.0 94.8 96.8 97.2 |
Kill smart effect test
The killing sperms in vitro test is detected by Inst of Science and Technology, State Family Planning Commission: according to " method is carried out in WHO human seminal fluid and sperm-cervical mucus interaction test handbook, experimental result shows: the compound recipe sterilization resists pregnant gel under 1: 6 dilution factor, and the sperm inactivation rate reaches 100% in 1 minute; Under 1: 30 dilution factor, the sperm inactivation rate reaches 100% in 1 minute; Under 1: 60 dilution factor, the sperm inactivation rate reaches 79.00 ± 3.92% in 1 minute; The sperm inactivation rate reaches 100% in 5 minutes.See Table 2.
Table 2: the anti-pregnant gel stock solution dilution of compound recipe sterilization is to the detection of people's sperm ability to function
| The stock solution thinner ratio | People's sperm mortality rate (%) and action time (min) | |
| 0～1min | 0～5min | |
| Contrast (BWW) in 1: 61: 30 1: 60 | 100 100 79.00±3.92 - | - - 100 25.40±10.5 |
Annotate: the anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization
The test of obstruct sperm
External obstruct people's sperm test (being undertaken): with reference to the Sander-CeamerShi method of WHO recommendation by attached three institutes of Zhongshan Medical Univ., result of the test shows: experimental group and blank group relatively in 5 seconds the sperm inactivation rate be significantly improved, there is remarkable statistical significance P＜after 0.001,1 minute obvious decline to be arranged to 30 minutes sperm survival rates; Test group 2 judges in 5 seconds in average 98.2%, 1 minute of the sperm inactivation ratio that by 0.1% Yihong dyeing liquor staining of sperm the sperm inactivation ratio is average 100%, significantly improves with the blank contrast, and significant difference P＜0.001 is arranged.See Table 3.
The test group agents useful for same: nano-silver water solution, concentration are 20ppm;
Test group 2 agents useful for same: the anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization;
Blank group agents useful for same: semen liquefaction
Table 3: external obstruct people sperm result of the test
| Group | Number of samples | Result of the test | ||||
| Average ratio % | 5 seconds | 1min | 10min | 30min | ||
| The blank group of test group I (not containing Octoxinol) gel II (containing Octoxinol) (semen liquefaction) | 20 20 20 | Inactivation rate inactivation ratio inactivation rate | 93.2 98.2 0.1 | 97.2 100.0 0.1 | 100.0 100.0 0.2 | 100.0 100.0 4.0 |
Kill and wound the clinical research of the reliability and the practicality of sperm
Clinical trial: the clinical research (Shanghai Second Medicine University subsidiary Renji Hospital) that the anti-pregnant gel of compound recipe sterilization kills and wounds the reliability and the practicality of sperm shows: 32 couples of this group experimenters all finish this test, and none comes off.Detect behind the masturbation extracting extract and find semen volume 2.1 ± 0.3ml, sperm concentration 74.54 ± 10.25 * 10
6/ ml, the average motility rate 70.64 ± 15.1% of sperm.Observing down the dyeing of sperm and Yihong by the microscope high power field finds: use 30min-1h, among 30 couples of Mr. and Mrs behind the wife's side arched roof all do not have sperm alive, do not have motile sperm in the 31 routine cervical mucuss, the sperm inactivation rate is 97.0%.When having 1 example to use back 30min, 2h, still have motile sperm in the cervix uteri broomcorn millet liquid, the percentage rate that sperm alive occurs is 3%.Investigate its using method and find, too small for using dosage, product injects and does not reach the required degree of depth of vagina.In the process of the test, all group Mr. and Mrs do not have serious adverse reactions such as penis, colpedema or erosion in the sexual intercourse process He after the sexual intercourse, and 2 examples use the wife's side, back vagina that slight burning sensation is arranged, but can tolerate, and burning sensation disappears in about 10min.With the sperm percentage comparisons of living during with bridegroom's or husband's side masturbation extracting extract in the anti-pregnant gel 30min-1h of compound recipe sterilization, the sperm percentage difference highly significant of living, statistical procedures P＜0.01 appear down in high power field.Vagina specimen smear, leucorrhea routine, vagina pH and bacterium vaginae are cultivated, and go into group and have a medical check-up and use behind the anti-pregnant gel 24h of compound recipe sterilization relatively statistical procedures there was no significant difference, P＞0.05.Gel-free is residual behind the 24h, and 30 couples of Mr. and Mrs are to contraception of this product and vaginal lubrication satisfactory effect among 32 couples of Mr. and Mrs, and satisfaction rate is 93.8%.
Nanometer silver conception control gel clinic trial Test Summary (Tongji Medical College, Huazhong Science and Technology Univ.'s family planning institute) clinical trial shows: 25 routine experimenters vagina under whole test is in the time all finds no motile sperm.All the other 5 routine experimenters, motile sperm mainly concentrates on the back 1min that has sexual intercourse, and sperm is classified as b level and c level, does not see a level sperm.Behind the 5min, only two routine experimenters find motile sperm, and behind the 10min, motile sperm is all braked.
The anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization
The comparison of compound recipe nanometer silver Octoxinol gel antibacterial tests effect
The nanometer silver group; The Octoxinol group; The anti-pregnant gel of compound recipe sterilization (detecting): carry out according to GB15979-2002 " disposable use hygienic article sanitary standard " appendix C regulation by Guangzhou Disease Prevention-Control Center, result of the test shows: the anti-pregnant gel of compound recipe sterilization acts on 2min, 20min under experimental condition, colibacillary bacteriostasis rate is respectively 94.7%, 98.0%; The nanometer silver group acts on 2min, 20min under experimental condition, colibacillary bacteriostasis rate is respectively 92.5%, 96.0%; The Octoxinol group acts on 2min, 20min under experimental condition, colibacillary bacteriostasis rate is respectively 85.3%, 90.2%; Three groups relatively, and better with anti-pregnant gel of compound recipe sterilization and nanometer silver group antibacterial action, the Octoxinol group is taken second place.See Table 4.
What the anti-pregnant gel group of compound recipe sterilization was used is the anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization;
What the nanometer silver group was used is nano-silver water solution, and concentration is 20ppm;
What Octoxinol used is Octoxinol, and weight percent concentration is 2%;
Table 4: three groups to escherichia coli in-vitro antibacterial result of the test
| Group | Activity | Action time (min) | Test group is deposited viable count meansigma methods (cfu/ml) | Matched group is deposited viable count meansigma methods (cfu/ml) | Bacteriostasis rate (%) |
| The anti-pregnant gel group of compound recipe sterilization | Stock solution | 2 5 10 20 | 4.0×103 3.1×103 2.5×103 1.5×103 | 7.6×104 7.2×104 7.0×104 7.6×104 | 94.7 95.7 96.4 98.0 |
| The nanometer silver group | 20ppm | 2 5 10 20 | 4.8×103 3.9×103 2.9×103 2.8×103 | 6.4×104 6.8×104 7.0×104 7.0×104 | 92.5 94.2 95.8 96.0 |
| The Octoxinol group | 2％ | 2 5 10 20 | 9.8×103 9.2×103 7.6×103 7.4×103 | 6.7×104 7.2×104 7.4×104 7.6×104 | 85.3 87.2 89.7 90.2 |
Nanometer silver group, the anti-pregnant gel of compound recipe sterilization, the external comparison of killing smart effect of Octoxinol group
Nanometer silver group, the anti-pregnant gel group of compound recipe sterilization; The external comparison (being undertaken) of killing smart effect of Octoxinol group: with reference to the Sander-CeamerShi method of WHO recommendation by attached three institutes of Zhongshan Medical Univ., result of the test shows: use the Ridit analytic process, the R value of the anti-pregnant gel group of compound recipe sterilization is 0.620, Octoxinol group R value is 0.495, nanometer silver group R value is 0.3210, in 95% credibility interval, the stealthy condom group of nanometer silver credibility interval is 0.531-0.693, Octoxinol group credibility interval is 0.380-0.595, nanometer silver group credibility interval 0.228-0.44z6, three groups have the different smart effects of killing.The R value of compound recipe nanometer silver Octoxinol gel group＞Octoxinol group R value＞nanometer silver group R value, the three relatively, compound recipe nanometer silver Octoxinol gel group kills that smart effect is better, the Octoxinol group is taken second place, the nanometer silver group is taken second place again.See Table 5.
What the anti-pregnant gel group of compound recipe sterilization was used is the anti-pregnant gel (seeing that Instructions Page 3 20-29 is capable) of compound recipe sterilization;
What the nanometer silver group was used is nano-silver water solution, and concentration is 20ppm;
What Octoxinol used is the Octoxinol aqueous solution, and weight percent concentration is 2%;
Table 5: three groups of external sperm result of the tests of killing a person
| Group | Number of samples | Result of the test | ||||
| The anti-pregnant gel group nanometer silver group of Octoxinol group compound recipe sterilization | 20 20 20 | Average ratio % inactivation ratio inactivation ratio inactivation ratio | 5 seconds 90.7 99.2 72.9 | 1 minute 93.7 100.0 78.6 | 10 minutes 100.0 100.0 84.5 | 30 minutes 100.0 100.0 95.4 |
The specific embodiment
Embodiment 1
Nanometer silver 0.07kg Octoxinol 15kg carbomer 15kg
Polyethylene Glycol-3350 30kg Polyethylene Glycol-400 50kg sodium laurylsulfate 0.5kg
Glycerol 200kg triethanolamine 150kg distilled water 550kg
The particle diameter of nanometer silver is 50 nanometers;
Preparation method: under normal temperature condition, nanometer silver, Octoxinol, sodium laurylsulfate, Polyethylene Glycol-400, Polyethylene Glycol-3350 are dissolved in the 150kg distilled water; Carbomer added in the glycerol to grind make moistening and the part swelling, the carbomer swellbility is 60%, add the 350kg distilled water and make it to absorb the abundant swelling of moisture until being translucent gel, again triethanolamine is dissolved in and adds above-mentioned gel in the 50kg distilled water, grind well into the transparent gel-type vehicle of stiff, add above-mentioned nanometer silver, Octoxinol solution, grind well, packing gets final product.
Embodiment 2
Nanometer silver 0.01kg nonoxynolum 13kg sodium carboxymethyl cellulose 10kg
The hard ester acid of Polyethylene Glycol-400 300kg Polyethylene Glycol-3350 400kg 50kg
Dodecyl sodium sulfate 0.5kg triethanolamine 15kg propylene glycol 65kg
Deionized water 146.42kg
The particle diameter of nanometer silver is 1 nanometer;
Preparation method: normal temperature condition is pressed recipe quantity with deionized water, sodium carboxymethyl cellulose, dodecyl sodium sulfate, triethanolamine, propylene glycol, Polyethylene Glycol-400, Polyethylene Glycol-3350 mixing and stirring down, adding nanometer silver, nonoxynolum stir, the hard ester acid of adding places and makes its mix homogeneously in the homogenizer under 60 ℃ of conditions, be cooled under stirring and solidify, packing gets final product.
Embodiment 3
Nanometer silver 0.1kg Menfegol 17kg Polyethylene Glycol-3350 200kg
Polyethylene Glycol-400 400kg polyvinylpyrrolidone 15kg stearic acid 14.5kg
Hard ester alcohol 35kg sodium lauryl sulphate 0.5kg triethanolamine 20kg
Glycerol 45kg distilled water 300kg
The particle diameter of nanometer silver is 100 nanometers;
Preparation method: normal temperature condition is pressed recipe quantity with distilled water, polyvinylpyrrolidone, sodium lauryl sulphate, triethanolamine, glycerol, Polyethylene Glycol-400, Polyethylene Glycol-3350 mixing and stirring down, adding nanometer silver, Octoxinol stir, adding stearic acid and hard ester alcohol place at last and make its mix homogeneously in the homogenizer under 75 ℃ of heating and stirring condition, be cooled under stirring and solidify, packing gets final product.
Embodiment 4
Benzalkonium chloride 15kg benzalkonium chloride 20kg polyvinyl alcohol 50kg
Cetyl trimethyl ammonium bromide 50kg α-monoalkyl glycerin ether 60kg
Glycerol 55kg deionized water 750kg
Preparation method: normal temperature condition is pressed recipe quantity with deionized water, polyvinyl alcohol, cetyl trimethyl ammonium bromide, α-monoalkyl glycerin ether, glycerol, mixing and stirring down, and adding benzalkonium chloride, benzalkonium chloride stir, and packing gets final product.
Embodiment 5
Benzalkonium bromide 50kg Menfegol 20kg carbomer 10kg
Polyethylene Glycol-400 100kg Polyethylene Glycol-3350 100kg sodium carboxymethyl cellulose 20kg
Polyoxyethylene polyoxypropylene copolyether 60kg polyglycereol-polybutylene fatty alcohol ether 50kg
Butyl stearate 30kg distilled water 560kg
Preparation method: normal temperature condition is pressed recipe quantity with distilled water, carbomer, sodium carboxymethyl cellulose, polyoxyethylene polyoxypropylene copolyether, polyglycereol-polybutylene fatty alcohol ether, butyl stearate, Polyethylene Glycol-400, Polyethylene Glycol-3350 mixing and stirring down, adding benzalkonium bromide, Menfegol stir, and packing gets final product.
Embodiment 6
Triclosan 30kg Alfenoxynol 10kg polyvinylpyrrolidone 30kg
Polyethylene Glycol-400 400kg polyvinyl alcohol 20kg isostearic acid isopropyl alcohol ester 30kg
Dodecyl dimethyl sodium acetate 50kg glycerol 45kg deionized water 385kg
Preparation method: normal temperature condition is pressed recipe quantity with deionized water, polyvinylpyrrolidone, polyvinyl alcohol, isostearic acid isopropyl alcohol ester, polyvinylpyrrolidone, dodecyl dimethyl sodium acetate, glycerol, Polyethylene Glycol-400 mixing and stirring down, adding triclosan, Alfenoxynol stir, and packing gets final product.
Embodiment 7
Chlorhexidine acetate 30kg menthylphenoxypolyethoxy ethanol 10kg sodium carboxymethyl cellulose 30kg
Polyvinyl alcohol 50kg alkylamide propyl-betaine 20kg
Alkyl imidazoline 30kg propylene glycol 200kg deionized water 630kg
Preparation method: normal temperature condition is pressed recipe quantity with deionized water, sodium carboxymethyl cellulose, polyvinyl alcohol, alkylamide propyl-betaine, alkyl imidazoline, propylene glycol, triethanolamine mixing and stirring down, adding chlorhexidine acetate, nonoxynolum stir, and packing gets final product.
Embodiment 8
Nanometer silver 0.1g Octoxinol 20g
Acritamer 940 15g triethanolamine 150g
Glycerol 200g deionized water 550g
Preparation method: under normal temperature condition, nanometer silver, Octoxinol are dissolved in the 150kg deionized water; Acritamer 940 added in the glycerol to grind make moistening and the part swelling, the carbomer swellbility is 50%, add the 350kg distilled water and make it to absorb the abundant swelling of moisture until being translucent gel, again triethanolamine is dissolved in and adds above-mentioned gel in the 50kg deionized water, grind well into the transparent gel-type vehicle of stiff, add above-mentioned nanometer silver, Octoxinol solution, grind well, packing gets final product.
Claims (16)
1, a kind of sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation of being used for is characterized in that comprising following components by part by weight:
Broad spectrum antimicrobicide 0.01-50, anti-pregnant spermicide 2-20.
2,, it is characterized in that comprising following components by part by weight according to the compound preparation of claim 1:
Broad spectrum antimicrobicide 15-50, anti-pregnant spermicide 2-20.
3,, it is characterized in that comprising following components by part by weight according to the compound preparation of claim 1:
Broad spectrum antimicrobicide 0.01-0.1, anti-pregnant spermicide 2-20.
4, according to the compound preparation of claim 1,2 or 3, it is characterized in that described compound preparation also comprises following components by part by weight: the adjuvant of water 90-750 and medically acceptable amount.
5,, it is characterized in that described broad spectrum antimicrobicide is a kind of or wherein several mixture of nanometer silver, benzalkonium chloride, benzalkonium bromide, chlorhexidine acetate, triclosan according to the compound preparation of claim 4.
6,, it is characterized in that described nanometer silver particle diameter is the 1-100 nanometer according to the compound preparation of claim 5.
7,, it is characterized in that described anti-pregnant spermicide is a kind of or wherein several mixture in Octoxinol, nonoxynolum, Alfenoxynol, Menfegol, the benzalkonium chloride according to the compound preparation of claim 1,2 or 3.
8,, it is characterized in that described adjuvant is a kind of or wherein several mixture in monomer carrier, surfactant and the dispersant according to the compound preparation of claim 4.
9,, it is characterized in that the weight part ratio of described adjuvant according to the compound preparation of claim 8:
Monomer carrier 15-815 surfactant 50-140 dispersant 45-350.
10,, it is characterized in that described monomer carrier is a kind of or wherein several mixture in carbomer, sodium carboxymethyl cellulose (CMC-Na), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), Polyethylene Glycol-400, the Polyethylene Glycol-3350 according to the compound preparation of claim 9.
11, according to the compound preparation of claim 9, it is characterized in that described surfactant is a sodium laurylsulfate, hard ester acid, hard ester alcohol, dodecyl sodium sulfate (AS), sodium lauryl sulphate (SDS), cetyl trimethyl ammonium bromide (CTAB), α-monoalkyl glycerin ether (GE), the polyoxyethylene polyoxypropylene copolyether, polyglycereol-polybutylene fatty alcohol ether (PGT alkyl ether), fructoside, butyl stearate, isostearic acid isopropyl alcohol ester, polyvinylpyrrolidone, dodecyl dimethyl sodium acetate (BS-12), alkylamide propyl-betaine, a kind of or wherein several mixture in the alkyl imidazoline.
12,, it is characterized in that described dispersant is a kind of or wherein several mixture in glycerol, propylene glycol, sodium laurylsulfate, the triethanolamine according to the compound preparation of claim 9.
13, the compound preparation of claim 4 is a gel.
14, a kind of method for preparing sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation comprises: under normal temperature condition water, monomer carrier, surfactant, dispersant are stirred, add broad spectrum antimicrobicide, resist pregnant spermicide to stir packing.
15, a kind of method for preparing sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation, comprise: under normal temperature condition, water, monomer carrier, surfactant, dispersant are stirred, add broad spectrum antimicrobicide, resist pregnant spermicide to stir, under 60-90 ℃ of heating and stirring condition, add hard ester acid and/or hard ester alcohol, mix homogeneously, be cooled under stirring and solidify packing.
16, a kind of method for preparing sterilizing and anti-pregnancy by killing sperm vagina administration compound preparation comprises: under normal temperature condition broad spectrum antimicrobicide, anti-pregnant spermicide are dissolved in the water; Carbomer added in the glycerol to grind make moistening and the part swelling, the carbomer swellbility is 40-60%, add entry and make it to absorb the abundant swelling of moisture until being translucent gel, again with the above-mentioned gel of dispersant adding soluble in water, grind well into the transparent gel-type vehicle of stiff, add above-mentioned broad spectrum antimicrobicide, anti-pregnant spermicide solution, grind well, packing gets final product.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027950A1 (en) * | 2006-08-30 | 2008-03-06 | Alllen Thomas K | Antimicrobial composition |
| CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
| CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
| CN101991858B (en) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | Novel externally applied auxiliary material and preparation method thereof |
| CN105168676A (en) * | 2015-09-25 | 2015-12-23 | 湖北穆兰同大科技有限公司 | Female safety antimicrobial gel and preparation method thereof |
| CN109260529A (en) * | 2018-10-15 | 2019-01-25 | 海氏海诺乳胶（青岛）有限公司 | A kind of antibacterial body lotion and preparation method thereof |
| CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生（天津）科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
| CN113230204A (en) * | 2021-05-21 | 2021-08-10 | 河南依维意实业有限公司 | Contraceptive gel with barrier and spermicidal double protection functions and preparation method thereof |
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2005
- 2005-10-13 CN CNB2005101083553A patent/CN100518825C/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027950A1 (en) * | 2006-08-30 | 2008-03-06 | Alllen Thomas K | Antimicrobial composition |
| CN101991858B (en) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | Novel externally applied auxiliary material and preparation method thereof |
| CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
| CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
| CN102266283B (en) * | 2011-07-29 | 2012-09-05 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
| CN105168676A (en) * | 2015-09-25 | 2015-12-23 | 湖北穆兰同大科技有限公司 | Female safety antimicrobial gel and preparation method thereof |
| CN105168676B (en) * | 2015-09-25 | 2019-12-03 | 湖北穆兰同大科技有限公司 | Safe bacteriostatic gel of Ms and preparation method thereof |
| CN109260529A (en) * | 2018-10-15 | 2019-01-25 | 海氏海诺乳胶（青岛）有限公司 | A kind of antibacterial body lotion and preparation method thereof |
| CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生（天津）科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
| CN113230204A (en) * | 2021-05-21 | 2021-08-10 | 河南依维意实业有限公司 | Contraceptive gel with barrier and spermicidal double protection functions and preparation method thereof |
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