CN1743004A - Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof - Google Patents
Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof Download PDFInfo
- Publication number
- CN1743004A CN1743004A CN 200510108355 CN200510108355A CN1743004A CN 1743004 A CN1743004 A CN 1743004A CN 200510108355 CN200510108355 CN 200510108355 CN 200510108355 A CN200510108355 A CN 200510108355A CN 1743004 A CN1743004 A CN 1743004A
- Authority
- CN
- China
- Prior art keywords
- compound preparation
- pregnant
- spermicide
- sperm
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 59
- 238000002360 preparation method Methods 0.000 title claims abstract description 49
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 238000000034 method Methods 0.000 claims abstract description 19
- 239000000934 spermatocidal agent Substances 0.000 claims abstract description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 45
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 41
- HNLXNOZHXNSSPN-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCOCCOCCOCCO)C=C1 HNLXNOZHXNSSPN-UHFFFAOYSA-N 0.000 claims description 29
- 229910052709 silver Inorganic materials 0.000 claims description 25
- 239000004332 silver Substances 0.000 claims description 25
- 238000003756 stirring Methods 0.000 claims description 23
- 229950004053 octoxinol Drugs 0.000 claims description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 17
- 210000001215 vagina Anatomy 0.000 claims description 17
- 150000002148 esters Chemical class 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 238000012856 packing Methods 0.000 claims description 15
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 13
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims description 13
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 12
- 229920002125 Sokalan® Polymers 0.000 claims description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 12
- 229960001631 carbomer Drugs 0.000 claims description 12
- 239000002270 dispersing agent Substances 0.000 claims description 12
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 claims description 11
- 229940050929 polyethylene glycol 3350 Drugs 0.000 claims description 11
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 11
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 10
- 239000000178 monomer Substances 0.000 claims description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 8
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 8
- 230000008961 swelling Effects 0.000 claims description 8
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 6
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims description 6
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 6
- NMXDTPBZWZGMMO-UHFFFAOYSA-N 4-(2-methyl-5-propan-2-ylcyclohexyl)phenol Chemical compound C1C(C(C)C)CCC(C)C1C1=CC=C(O)C=C1 NMXDTPBZWZGMMO-UHFFFAOYSA-N 0.000 claims description 5
- -1 alkyl imidazoline Chemical compound 0.000 claims description 5
- 229960001112 menfegol Drugs 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 claims description 4
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 claims description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- 229960002233 benzalkonium bromide Drugs 0.000 claims description 4
- KHSLHYAUZSPBIU-UHFFFAOYSA-M benzododecinium bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 KHSLHYAUZSPBIU-UHFFFAOYSA-M 0.000 claims description 4
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 4
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 150000002191 fatty alcohols Chemical class 0.000 claims description 4
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 claims description 4
- 229920001748 polybutylene Polymers 0.000 claims description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 4
- NEOZOXKVMDBOSG-UHFFFAOYSA-N propan-2-yl 16-methylheptadecanoate Chemical group CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C NEOZOXKVMDBOSG-UHFFFAOYSA-N 0.000 claims description 4
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 4
- 235000017281 sodium acetate Nutrition 0.000 claims description 4
- 239000001632 sodium acetate Substances 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 150000005215 alkyl ethers Chemical class 0.000 claims description 2
- 229930182479 fructoside Natural products 0.000 claims description 2
- 235000013772 propylene glycol Nutrition 0.000 claims description 2
- 229940009188 silver Drugs 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 25
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001150 spermicidal effect Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 32
- 230000002779 inactivation Effects 0.000 description 20
- 230000000694 effects Effects 0.000 description 15
- 239000008367 deionised water Substances 0.000 description 11
- 229910021641 deionized water Inorganic materials 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 239000012153 distilled water Substances 0.000 description 9
- 239000012895 dilution Substances 0.000 description 7
- 238000010790 dilution Methods 0.000 description 7
- 230000002254 contraceptive effect Effects 0.000 description 6
- 230000001568 sexual effect Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000011550 stock solution Substances 0.000 description 6
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 239000003433 contraceptive agent Substances 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000222122 Candida albicans Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000001888 Peptone Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229940095731 candida albicans Drugs 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 206010006784 Burning sensation Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 206010052428 Wound Diseases 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000003679 cervix uteri Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 229940127234 oral contraceptive Drugs 0.000 description 2
- 239000003539 oral contraceptive agent Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000005659 seminal clot liquefaction Effects 0.000 description 2
- 238000012109 statistical procedure Methods 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229960004418 trolamine Drugs 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 235000007199 Panicum miliaceum Nutrition 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 206010044248 Toxic shock syndrome Diseases 0.000 description 1
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000022185 broomcorn panic Species 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 210000005224 forefinger Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Test strain | Activity | Action time (min) | Test group is deposited viable count meansigma methods (cfu/ml) | Matched group is deposited viable count meansigma methods (cfu/ml) | Bacteriostasis rate (%) |
Escherichia coli 8099 | Stock solution | 2 5 10 20 | 4.2×103 3.4×103 2.8×103 2.5×103 | 6.8×104 6.9×104 7.2×104 7.8×104 | 93.8 95.1 96.1 98.3 |
Staphylococcus aureus ATCC6538 | Stock solution | 2 5 10 20 | 1.1×103 0.8×103 0.7×103 0.4×103 | 5.3×104 5.6×104 5.5×104 5.7×104 | 97.9 98.6 98.7 99.3 |
Candida albicans ATCC10231 | Stock solution | 2 5 10 20 | 2.9×103 2.8×103 1.8×103 1.6×103 | 5.7×104 5.8×104 5.4×104 5.7×104 | 95.0 94.8 96.8 97.2 |
The stock solution thinner ratio | People's sperm mortality rate (%) and action time (min) | |
0~1min | 0~5min | |
Contrast (BWW) in 1: 61: 30 1: 60 | 100 100 79.00±3.92 - | - - 100 25.40±10.5 |
Group | Number of samples | Result of the test | ||||
Average ratio % | 5 seconds | 1min | 10min | 30min |
The blank group of test group I (not containing Octoxinol) gel II (containing Octoxinol) (semen liquefaction) | 20 20 20 | Inactivation rate inactivation ratio inactivation rate | 93.2 98.2 0.1 | 97.2 100.0 0.1 | 100.0 100.0 0.2 | 100.0 100.0 4.0 |
Group | Activity | Action time (min) | Test group is deposited viable count meansigma methods (cfu/ml) | Matched group is deposited viable count meansigma methods (cfu/ml) | Bacteriostasis rate (%) |
The anti-pregnant gel group of compound recipe sterilization | Stock solution | 2 5 10 20 | 4.0×103 3.1×103 2.5×103 1.5×103 | 7.6×104 7.2×104 7.0×104 7.6×104 | 94.7 95.7 96.4 98.0 |
The nanometer silver group | 20ppm | 2 5 10 20 | 4.8×103 3.9×103 2.9×103 2.8×103 | 6.4×104 6.8×104 7.0×104 7.0×104 | 92.5 94.2 95.8 96.0 |
The Octoxinol group | 2% | 2 5 10 20 | 9.8×103 9.2×103 7.6×103 7.4×103 | 6.7×104 7.2×104 7.4×104 7.6×104 | 85.3 87.2 89.7 90.2 |
Group | Number of samples | Result of the test | ||||
The anti-pregnant gel group nanometer silver group of Octoxinol group compound recipe sterilization | 20 20 20 | Average ratio % inactivation ratio inactivation ratio inactivation ratio | 5 seconds 90.7 99.2 72.9 | 1 minute 93.7 100.0 78.6 | 10 minutes 100.0 100.0 84.5 | 30 minutes 100.0 100.0 95.4 |
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101083553A CN100518825C (en) | 2005-10-13 | 2005-10-13 | Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2005101083553A CN100518825C (en) | 2005-10-13 | 2005-10-13 | Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1743004A true CN1743004A (en) | 2006-03-08 |
CN100518825C CN100518825C (en) | 2009-07-29 |
Family
ID=36138627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005101083553A Active CN100518825C (en) | 2005-10-13 | 2005-10-13 | Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100518825C (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008027950A1 (en) * | 2006-08-30 | 2008-03-06 | Alllen Thomas K | Antimicrobial composition |
CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
CN101991858B (en) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | Novel externally applied auxiliary material and preparation method thereof |
CN105168676A (en) * | 2015-09-25 | 2015-12-23 | 湖北穆兰同大科技有限公司 | Female safety antimicrobial gel and preparation method thereof |
CN109260529A (en) * | 2018-10-15 | 2019-01-25 | 海氏海诺乳胶(青岛)有限公司 | A kind of antibacterial body lotion and preparation method thereof |
CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生(天津)科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
CN113230204A (en) * | 2021-05-21 | 2021-08-10 | 河南依维意实业有限公司 | Contraceptive gel with barrier and spermicidal double protection functions and preparation method thereof |
-
2005
- 2005-10-13 CN CNB2005101083553A patent/CN100518825C/en active Active
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008027950A1 (en) * | 2006-08-30 | 2008-03-06 | Alllen Thomas K | Antimicrobial composition |
CN101991858B (en) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | Novel externally applied auxiliary material and preparation method thereof |
CN102335161A (en) * | 2011-07-15 | 2012-02-01 | 成都顺发消洗科技有限公司 | Spermicide for disinfecting skin and mucous membrane, preparation method thereof |
CN102266283A (en) * | 2011-07-29 | 2011-12-07 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
CN102266283B (en) * | 2011-07-29 | 2012-09-05 | 石家庄诺利达医疗器械有限公司 | Acidic buffering sterilization gel for vagina gynaecologically |
CN105168676A (en) * | 2015-09-25 | 2015-12-23 | 湖北穆兰同大科技有限公司 | Female safety antimicrobial gel and preparation method thereof |
CN105168676B (en) * | 2015-09-25 | 2019-12-03 | 湖北穆兰同大科技有限公司 | Safe bacteriostatic gel of Ms and preparation method thereof |
CN109260529A (en) * | 2018-10-15 | 2019-01-25 | 海氏海诺乳胶(青岛)有限公司 | A kind of antibacterial body lotion and preparation method thereof |
CN111345288A (en) * | 2020-03-12 | 2020-06-30 | 优仕康生(天津)科技发展有限公司 | A colloidal carrier capable of forming antibacterial and antiviral coating on the surface of respiratory protector, colloidal tincture and application thereof |
CN113230204A (en) * | 2021-05-21 | 2021-08-10 | 河南依维意实业有限公司 | Contraceptive gel with barrier and spermicidal double protection functions and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN100518825C (en) | 2009-07-29 |
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Inventor after: Zhou Huayue Inventor before: Zhou Xuming |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 524018 SHENZHEN, GUANGDONG PROVINCE TO: 524000 ZHANJIANG, GUANGDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: ZHOU XUMING TO: ZHOU HUAYAO |
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TR01 | Transfer of patent right |
Effective date of registration: 20130506 Address after: 524000 Guangdong Province, Zhanjiang city Xiashan District Shen five Sichuan Road No. 4 Patentee after: Guangdong Tongde Pharmaceutical Co., Ltd. Address before: Luohu District Patriotic Road Shenzhen city Guangdong province 524018 No. 3001 East Lake Lai 1 building 201 Patentee before: Zhou Xuming |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a compound preparation for spermicide, anti pregnancy, sterilization and disinfection and a preparation method thereof Effective date of registration: 20220401 Granted publication date: 20090729 Pledgee: Agricultural Bank of China Limited Zhanjiang Xiashan sub branch Pledgor: GUANGDONG TONGDE PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980003781 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |