CN106214882A - A kind of high intensity antibacterial liquid gel and preparation method thereof - Google Patents

A kind of high intensity antibacterial liquid gel and preparation method thereof Download PDF

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Publication number
CN106214882A
CN106214882A CN201610693635.3A CN201610693635A CN106214882A CN 106214882 A CN106214882 A CN 106214882A CN 201610693635 A CN201610693635 A CN 201610693635A CN 106214882 A CN106214882 A CN 106214882A
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Prior art keywords
gel
high intensity
purified water
antibacterial liquid
composition
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CN201610693635.3A
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Inventor
尹志明
刘动勤
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Jian Royal Beauty Health Co Ltd
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Jian Royal Beauty Health Co Ltd
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Priority to CN201610693635.3A priority Critical patent/CN106214882A/en
Publication of CN106214882A publication Critical patent/CN106214882A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/717—Celluloses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234—Cnidium (snowparsley)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A kind of high intensity antibacterial liquid gel and preparation method thereof, it is characterized in that: the composition of this gel and percentage by weight composition include: benzalkonium chloride 0.08% 1.2%, Aloe glue 0.01% 2%, Herba Menthae 0.01% 0.1%, Fructus Cnidii 0.02 0.1%, hypromellose 0.5 10%, propylene glycol 0.5 10%, chlorhexidine acetate≤0.3%, hyaluronic acid 1 6%, surplus is purified water.Have that side effect is little, good effect, and be not easily caused the advantage that reproductive tract flora is unbalance, can effectively alleviate or cure the state of an illness.

Description

A kind of high intensity antibacterial liquid gel and preparation method thereof
Technical field
The present invention relates to gel rubber material technical field, be specifically related to a kind of high intensity (has chemical sterilization composition and thing simultaneously The composition of reason shielding action) antibacterial liquid gel and preparation method thereof.
Background technology
Along with change and the deterioration of surrounding of philosophy of life, reproductive tract infection increasingly becomes common in women Disease and frequently-occurring disease.It is mainly to occur at a class infectious disease of female reproductive system, is mainly propagated by sexual approach, Wherein most commonly seen with vaginitis, cervicitis, pelvic inflammatory disease, adnexitis etc..And if employing oral drug therapy, a secondary work With greatly, two can not directly act on affected part, and curative effect is the most notable；At present, use gel rubber material is also had directly to carry out acting on trouble Place acts on, the most rapid-action, evident in efficacy, but still there is certain deficiency: such as chemical reagent composition content is big, still There is bigger side effect, additionally, be also easy to cause vaginal microbial flora unbalance, it is impossible to effectively alleviate or cure the state of an illness.
Summary of the invention
The present invention is directed to the above-mentioned deficiency of prior art, it is provided that a kind of side effect is little, good effect, and is not easily caused reproductive tract Flora is unbalance, can effectively alleviate or cure the high intensity antibacterial liquid gel of the state of an illness.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is: a kind of high intensity antibacterial liquid gel, should The composition of gel and percentage by weight composition include: benzalkonium chloride 0.08%-1.2%, Aloe glue 0.01%-2%, Herba Menthae 0.01%-0.1%, Fructus Cnidii 0.02-0.1%, hypromellose 0.5-10%, propylene glycol 0.5-10%, chlorhexidine acetate ≤ 0.3%, hyaluronic acid 1-6%, surplus is purified water.
As further preferably, the high intensity antibacterial liquid gel that the present invention is above-mentioned, the composition of this gel and weight percent Include than composition: benzalkonium chloride 1%-1.2%, Aloe glue 0..5%-2%, Herba Menthae 0.05%-0.1%, Fructus Cnidii 0.03- 0.08%, hypromellose 0.6-3%, propylene glycol 1-3%, chlorhexidine acetate≤0.3%, hyaluronic acid 2-5%, surplus is Purified water.
The above-mentioned hyalomitome acid of the present invention is hyaluronate sodium.
The chlorhexidine acetate of the present invention is 0.001-0.02%.
The present invention also provides for the preparation method of a kind of aforesaid liquid gel, and preparation process includes:
(1) in the case of being stirred continuously, first hyaluronic acid is slowly added into part and goes in purified water, be allowed to dissolve Completely；
(2) by said mixture suction vacuum emulsification tank, more remaining purified water, propylene glycol, Aloe glue, acetic acid will be removed Chlorine, hypromellose add in vacuum emulsification tank the most surely, stirring evacuation degassing；
(3) after thing mixed above dissolves completely, adding other surplus stock, continue to stir evenly rear evacuation, degassing is to producing Product bubble-free, is cooled to room temperature.
Advantages of the present invention and beneficial effect:
1. the present invention is first by benzalkonium chloride 0.08%-1.2%, Aloe glue 0.01%-2%, Herba Menthae 0.01%-0.1%, Fructus Cnidii 0.02-0.1%, hypromellose 0.5-10%, propylene glycol 0.5-10%, chlorhexidine acetate≤0.3%, hyalomitome Acid 1-6%, surplus is that the proportioning of purified water mixes, and Aloe glue therein, Herba Menthae, Fructus Cnidii are the Chinese medicine of pure natural and become Point, there is anti-inflammation and sterilization, cleaning skin protection, prevent the phenomenons such as slack vagina, dry and astringent, aging, keratinization, atrophy, it is to avoid at sexual life Virus is infected in medial vagina friction breakage；Can effectively kill mycoplasma, chlamydia, gonococcus, trichomonal vaginitis etc.；And to life Growing non-stimulated, gentleer safety, side effect is little, and effective drug duration is long.
2. the product of the present invention employs a small amount of even benzalkonium chloride of trace, hypromellose, chlorhexidine acetate Deng, it is possible to Candida albicans, escherichia coli, 2 minutes killing rates of staphylococcus effect are all higher than 90.00%；Evident in efficacy.
3. the product of the present invention is shielded women vagina and wall of cervix by chemical sterilization and physical shielding effect, can be at the moon Preserve for a long time in road and do not destroy the self-purification function of the sour environment of vagina itself.Physical barriers two-way function, at sexual life Middle cream liquid can stop cell entry uterine infection vagina at men and women's reproduction orga-nogenesis protective layer, completely cuts off bacterial invasion male urine Road induced disease, the property of medicine play spermicidal go out poison double effects, the property of medicine be up to more than 8 hours.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in more detail, but is not limited only to following example.
Embodiment 1
The composition of this gel and percentage by weight composition include: benzalkonium chloride 0.08%, Aloe glue 0.8%, Herba Menthae 0.05%, Fructus Cnidii 0.025%, hypromellose 1%, propylene glycol 0.8%, chlorhexidine acetate 0.25%, hyaluronic acid 5%, surplus is purified water.
The above-mentioned hyalomitome acid of the present invention is hyaluronate sodium.
The present invention also provides for the preparation method of a kind of aforesaid liquid gel, and preparation process includes:
(1) in the case of being stirred continuously, first hyaluronic acid is slowly added into part and goes in purified water, be allowed to dissolve Completely；
(2) by said mixture suction vacuum emulsification tank, more remaining purified water, propylene glycol, Aloe glue, acetic acid will be removed Chlorine, hypromellose add in vacuum emulsification tank the most surely, stirring evacuation degassing；
(3) after thing mixed above dissolves completely, adding other surplus stock, continue to stir evenly rear evacuation, degassing is to producing Product bubble-free, is cooled to room temperature.
Embodiment 2
The composition of this gel and percentage by weight composition include: benzalkonium chloride 1.1%, Aloe glue 1.5%, Herba Menthae 0.08%, Fructus Cnidii 0.06%, hypromellose 1.5%, propylene glycol 1.2%, chlorhexidine acetate 0.3%, hyaluronic acid 5%, surplus is purified water.
Method is with embodiment 1.
Embodiment 3
The composition of this gel and percentage by weight composition include: benzalkonium chloride 1.2%, Aloe glue 2%, Herba Menthae 0.1%, Serpentis Machine tool 0.1%, hypromellose 5%, propylene glycol 2%, chlorhexidine acetate 0.2%, hyaluronic acid 3%, surplus is purified water.
Method is with embodiment 1.
Comparative example
The composition of this gel and percentage by weight composition include: benzalkonium chloride 1.2%, Aloe glue 2%, Herba Menthae 0.1%, Serpentis Machine tool 0.1%, hypromellose 5%, propylene glycol 2%, hyaluronic acid 3%, surplus is purified water.
Method is with embodiment 1.
Sample prepared by the embodiment of the present invention, using effect: volunteer is divided into 2 groups, often organizes 100 people.First group After (test group) volunteer cleans vagina by warm water every night, the gel 3g of Example 1 preparation is coated on labia week Enclose with vagina inside；Second group (matched group) takes commercially available vaginitis antibacterial gel and compares, each consumption 3g；Often group uses continuously Carry out after two weeks checking for the first time, second time check after 10 weeks；3rd group (comparative example group) takes vagina prepared by comparative example Scorching antibacterial gel compares, each consumption 3g；Often group carries out after using two weeks continuously checking for the first time, second time after 10 weeks Review result is shown in Table 1.
1 liang of table group patient clinical Comparison of therapeutic
Group N Cure Effective Invalid Total effective rate
Observation group 100 89 8 3 97%
Comparative example group 100 80 6 14 86%
Matched group 100 78 5 17 83%
As can be known from the above table, the gel that prepared by the present invention has cure rate advantage high, eutherapeutic；Comparative example confirms simultaneously, If not using chlorhexidine acetate, losing the synergy between each component, result in various material and cannot play collaborative work With, reduce total effective rate.

Claims (4)

1. a high intensity antibacterial liquid gel, it is characterised in that: the composition of this gel and percentage by weight composition include: benzene is pricked Oronain 0.08%-1.2%, Aloe glue 0.01%-2%, Herba Menthae 0.01%-0.1%, Fructus Cnidii 0.02-0.1%, hydroxypropyl first is fine Dimension element 0.5-10%, propylene glycol 0.5-10%, chlorhexidine acetate≤0.3%, hyaluronic acid 1-6%, surplus is purified water.
High intensity antibacterial liquid gel the most according to claim 1, it is characterised in that: the composition of this gel and weight percent Include than composition: benzalkonium chloride 1%-1.2%, Aloe glue 0..5%-2%, Herba Menthae 0.05%-0.1%, Fructus Cnidii 0.03- 0.08%, hypromellose 0.6-3%, propylene glycol 1-3%, chlorhexidine acetate≤0.3%, hyaluronic acid 2-5%, surplus is Purified water.
High intensity antibacterial liquid gel the most according to claim 2, it is characterised in that: described chlorhexidine acetate is 0.001-0.02%.
4. a preparation method for the high intensity antibacterial liquid gel described in claim 1-3 any claim, its feature exists In: preparation process includes:
(1) in the case of being stirred continuously, first hyaluronic acid is slowly added into part and goes in purified water, be allowed to dissolve Entirely；
(2) by said mixture suction vacuum emulsification tank, more remaining purified water, propylene glycol, Aloe glue, acetic acid chlorine, hydroxyl will be removed Third methylcellulose adds in vacuum emulsification tank the most surely, stirring evacuation degassing；
(3) after thing mixed above dissolves completely, add other surplus stock, continue to stir evenly rear evacuation, deaerate to product without Bubble, is cooled to room temperature.
CN201610693635.3A 2016-08-19 2016-08-19 A kind of high intensity antibacterial liquid gel and preparation method thereof Pending CN106214882A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108420789A (en) * 2018-04-16 2018-08-21 海南皇隆制药股份有限公司 A kind of benzalkonium chloride externally used solution and preparation method thereof
CN109200015A (en) * 2017-07-07 2019-01-15 海南皇隆制药股份有限公司 A kind of amikacin externally used solution and preparation method thereof
CN112190541A (en) * 2020-09-27 2021-01-08 安婕妤化妆品科技股份有限公司 Privacy care gel product

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Publication number Priority date Publication date Assignee Title
CN1371734A (en) * 2002-03-05 2002-10-02 黄林记 Ointment capable of quick sterilizing AIDS, veneral virus and spermatozoa and preparation process thereof
CN1634007A (en) * 2004-11-01 2005-07-06 黄林记 Benzalkonium chloride contraceptive gel for quick eradication of multiple venereal disease pathogenic organism
CN105816551A (en) * 2016-03-09 2016-08-03 袁俊杰 Medicinal film used for treating gynecological diseases and maintaining female external genital organs, and production method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1371734A (en) * 2002-03-05 2002-10-02 黄林记 Ointment capable of quick sterilizing AIDS, veneral virus and spermatozoa and preparation process thereof
CN1634007A (en) * 2004-11-01 2005-07-06 黄林记 Benzalkonium chloride contraceptive gel for quick eradication of multiple venereal disease pathogenic organism
CN105816551A (en) * 2016-03-09 2016-08-03 袁俊杰 Medicinal film used for treating gynecological diseases and maintaining female external genital organs, and production method thereof

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Title
杨锐: "中药凝胶剂的研究进展及其在阴道给药方面的应用", 《"好医生杯"中药制剂创新与发展论坛论文集（下）》 *
金亚丽、王曙东、李德平: "中药熏洗剂在妇科的临床应用", 《中医药研究》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109200015A (en) * 2017-07-07 2019-01-15 海南皇隆制药股份有限公司 A kind of amikacin externally used solution and preparation method thereof
CN108420789A (en) * 2018-04-16 2018-08-21 海南皇隆制药股份有限公司 A kind of benzalkonium chloride externally used solution and preparation method thereof
CN112190541A (en) * 2020-09-27 2021-01-08 安婕妤化妆品科技股份有限公司 Privacy care gel product

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Application publication date: 20161214