CN101991858B - Novel externally applied auxiliary material and preparation method thereof - Google Patents
Novel externally applied auxiliary material and preparation method thereof Download PDFInfo
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- CN101991858B CN101991858B CN2009100701513A CN200910070151A CN101991858B CN 101991858 B CN101991858 B CN 101991858B CN 2009100701513 A CN2009100701513 A CN 2009100701513A CN 200910070151 A CN200910070151 A CN 200910070151A CN 101991858 B CN101991858 B CN 101991858B
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Abstract
The invention discloses a novel externally applied auxiliary material and a preparation method thereof. The novel externally applied auxiliary material comprises the following raw materials in parts by weight: 18-30 parts of glycerol, 1.5-4 parts of carbomer, 1-4.5 parts of gelatin, 10-36 parts of distilled water, 0.1-2.4 parts of triethanolamine, 0.5-3 parts of polyvinylpyrrolidone and 0.06-0.6 parts of methylparaben. The invention has the characteristics of large loading rate, good appetency of various medicine powder, extractum and the like, unique release effect, strong transdermal effect, good ventilation and closer skin appetency. Compared with the traditional external preparation, the novel externally applied auxiliary material has the advantages of safe manufacturing process, environment protection, no stimulation to skin, no anaphylaxis and comfortable sticking and repeatable uncovering and sticking, stable auxiliary performance and no reaction with main medicines, and is suitable for externally applied preparations manufactured in industrial production, and provides application foundation for externally applied medicine treatment of a plurality of diseases and external use of plant medicines. Meanwhile, the externally applied preparations for medical treatment and cosmeceuticals, which are prepared from the novel externally applied auxiliary material, can be used more conveniently, can maintain water for longer time, has specific release function, and can better achieve the treatment effects. The invention provides an excellent operation platform for externally applied preparation products of medical treatment and cosmeceuticals.
Description
Technical field
The invention belongs to medicine external preparation technical field, particularly relate to a kind of novel external adjuvant and preparation method thereof.
Background technology
External preparation is meant not means such as oral administration, drug administration by injection, directly is used for the preparation of skin, mucosa or tract.Majority is brought into play curative effect through local action, but the external preparation that also has is to be used to treat systemic disease or non-agents area treatment of diseases.Its distinct advantages is to avoid liver first-pass effect and medicine to degrade at gastrointestinal; Constant speed release medicine reduces adverse effect etc.The common form of expression of external preparation has patch, ointment, suppository etc., and wherein patch is that people contact at most, one of most widely used external preparation in the daily life.
External use plaster then refers to traditional patch more, is an important component part in motherland's medicine and pharmacology, is the traditional Chinese medical science five big pharmaceutical dosage form--balls, looses cream, pellet, one of soup.As the external treatment with Chinese medicine therapy of a kind of uniqueness in motherland's medical science, existing bimillennial history, and be widely used in treating various diseases, receive broad masses of the people's welcome deeply.It is to utilize medicine, imposes on patient's body surface or affected part, borrows body surface to the absorption of medicine and the path of meridians, brings into play the medicine activating blood circulation to dissipate blood stasis, the granulation promoting pain relieving, and the Lip river of stimulating the menstrual flow away, it is deep to have one's ideas straightened out, the function of expelling wind and cold, thus reach a kind of preparation of various effect purposes.The theory of Chinese medicine: the well-known doctor of Qing Dynasty Xu Hui Xi once had such one section argumentation: " it has two: one to control table with big end for modern used plaster, the plaster applying a plaster for therapeutic purpose of ancients' meaning; One with in controlling.The person that controls the table, as exhale the pus removing the necrotic tissue, pain relieving granulation promoting, and pick up wind and protect meat and so on, its cream should be frivolous and day change, and this reason people is prone to knowledge; Person in controlling, or wind dispelling is cold, or and QI and blood, or expectorant painful abdominal mass, or strengthening bone and muscle; Its side is a lot of, and medicine is also with disease plus-minus, suitable thick and subsides of a specified duration of its cream, the difficulty knowledge of this reason people institute; What also? " He explains again: " with patch it, inaccessible its gas makes the property of medicine go into its space between skin and muscles from pore, stimulates the menstrual flow and passes through network; or carry it, or attacks and loose it, and is particularly strong than taking medicine, this to wonderful method also." this section argumentation illustrated the mechanism of the skin absorbs of external use plaster quite clearly, and confirmed by the modern science experiment: the drug transdermal absorption process comprises releases, penetrates and absorbs entering blood circulation three phases.Release means that medicine spins off and is diffused on skin or the mucomembranous surface from substrate.Penetrate and mean that medicine passes through epidermis and gets into corium, subcutaneous tissue, effect is organized in the part.Absorption means that medicine penetrates behind the skin or contacts the back with mucosa and in tissue, gets into body through blood vessel or lymphatic vessel and circulate and produce general action.
Be that traditional external plaster (ointment medicine, black plaster) is confirmed by modern medicine, the heavy metal substance that is contained in the preparation is poisonous like compositions such as lead, hydrargyrum; And traditional plaster is many to be substrate with fat-soluble material etc., and more serious defective is arranged in application, and the medicine carrying capacity is little, the transdermal poor performance; Irritated, erythra; Adhesion fine hair, pollution clothes etc. use traditional external use plaster and have received very big restriction, face problems., how traditional plaster is improved for this reason, made it when keeping traditional medicine marrow,, weed out the old and bring forth the new, become expert's primary study direction in conjunction with modern scientific and technical result.Therefore, develop all excellent external adjuvant of a kind of various performance and just seem particularly important as the base stock of external preparation production.
Summary of the invention
The shortcoming that the objective of the invention is to overcome prior art provides a kind of novel external adjuvant that is suitable for large-scale industrial production with not enough.
Another object of the present invention has provided the preparation technology of above-mentioned novel external adjuvant.
A further object of the present invention discloses application and the application preparation cosmetics for external use aspect of novel external adjuvant aspect preparation external preparation medicine, the application of the substrate aspect when particularly preparing external preparation.For realizing above-mentioned purpose, the present invention provides following technical scheme:
A kind of novel external adjuvant is characterized in that being made up of the raw material of following ratio of weight and number:
18～30 parts of glycerin, 1.5～4 parts of carbomers, 1～4.5 part in gelatin, 10～36 parts of distilled water,
0.1～2.4 part of triethanolamine, 0.5～3 part of polyvinylpyrrolidone, 0.06～0.6 part of methyl hydroxybenzoate.
Novel external adjuvant of the present invention, preferably the raw material by following ratio of weight and number is made:
20～25 parts of glycerin, 1.5～3.5 parts of carbomers, 3～4.5 parts in gelatin, 15～30 parts of distilled water,
0.4～2.0 part of triethanolamine, 0.5～1 part of polyvinylpyrrolidone, 0.1～0.4 part of methyl hydroxybenzoate.
The method for preparing of novel external adjuvant of the present invention comprises the steps:
(1) with carbomer add stir in the glycerin after, add gelatin be stirred to mix fully the I phase;
(2) adopt agitator to add polyvinylpyrrolidone behind the mix homogeneously mutually an amount of hot distilled water, make the II phase with I;
(3) triethanolamine is added in an amount of distilled water, the dissolving back adds the II phase, gets the III phase after reacting completely;
(4) methyl hydroxybenzoate adding residue distilled water is dissolved back adding III fully and promptly get this novel external adjuvant mutually.
Novel external adjuvant of the present invention carries to existing external preparation that substrate is fully analyzed and in addition great improvement, succeed in developing finally possess simultaneously contain that dose is big, transdermal effect good, the dose composition is controlled and slow release, good permeability, to the novel external adjuvant of five big characteristics such as skin is non-stimulated.It is major ingredient that this adjuvant adopts animal skins bone extract pharmagel first at home and abroad; Collocation synthesizing water-solubility macromolecular compound; Unique prescription and the technology of its adjuvant is domestic and international initiative; Promote for convenient external preparation cosmetics, be the external medication of multiple disease, especially the external of Chinese medicine provides application foundation widely.
Preparation technology's of the present invention characteristic is: note the different size proportion of raw materials in the screening of auxiliary material proportioning; Take into full account the release performance and the transdermal effect of mastic Chinese medicine; Also take into account the variation of adhesion simultaneously; And physical behavior two aspects during to experimental result and external plaster molding combine to estimate, thereby select proper raw material and proportioning.Confirmed the kind and the proportioning of each composition in the substrate through repetition test; It wherein is example with the polyvinylpyrrolidone; Polyvinylpyrrolidone (polyvinyl pyrrolidone) is called for short PVP; Being a kind of non-ionic macromolecule compound, is most characteristic in the N vinylamide polymer, and be studied the most deeply, fine chemicals kind widely.Polyvinylpyrrolidone has good physiology inertia, does not participate in the human body metabolism, has good biocompatibility again, and skin, mucosa, eye etc. are not formed any stimulation, and the record of life-time service is arranged in field of medicaments, and it is very safe to be used for cosmetics etc.In daily cosmetics, polyvinylpyrrolidone and copolymer have good dispersion and film property, and polyvinylpyrrolidone has the effect of protecting colloid in emulsion, can be used in fatty and the non-fatty mastic.From biological viewpoint; The molecular structure characteristic of polyvinylpyrrolidone is similar to the sort of structure with simple protein model, and its water solublity is to some micromolecular mating capability and can also be mixed with protein by characteristics such as some proteinic precipitant ammonium sulfate, trichloroacetic acid, tannic acid and phenols precipitate even.So that make polyvinylpyrrolidone be widely used as the adjuvant of pharmaceutical preparation.Polyvinylpyrrolidone is as a kind of synthesizing water-solubility macromolecular compound; Have water-soluble high-molecular compound as character; Colloid protective effect, film property, caking property, hygroscopicity, solubilising or cohesion; But it is most characteristic, thereby what receive that people pay attention to is its excellent solubility property and physiological compatibility.Both water-soluble as polyvinylpyrrolidone in synthetic high polymer; Be dissolved in actually rare that most of organic solvent, toxicity are very low, the physiology intermiscibility is good again; Particularly in medicine, food, cosmetics these and the closely-related field of health of people, show the good prospect of its development.
Another kind of adjuvant water-soluble macromolecule material carbomer is a white loose powder art, has stronger hygroscopicity.Owing to contain 52 ~ 68% acid groups in its molecular structure, therefore have certain acidity, the PH of 1% aqueous dispersion is 2.5 ~ 3.0.Available alkaline matter neutralization forms gel.After the carbomer resin is neutralized and makes carboxylic ionsization, because the repulsive interaction of negative charge stretches the strand disperse; Be great swelling state and tool viscosity; It can be used as good suspension agent, stabilizing agent, emulsifying agent; The residuite of superior cosmetics and pharmaceutic adjuvant substrate also are the most effective water-soluble thickeners.
And as novel external adjuvant major ingredient pharmagel of the present invention, then be to select animal skins, bone and muscle tendon for use, handle the senior glue article that make through complicated physics and chemistry.Have the viscosity height, freeze the power height, physical characteristics such as be prone to congeal.Gelatin dissolves in hot water, forms the thermal reversibility gel, and it has extremely good physical property, like jelly power, affinity, high dispersion, low viscosity characteristics, dispersion stabilization, retentiveness, and lining property, toughness and reversibility etc.With in the present invention, embossability and adhesion strength behind the novel external adjuvant pastille of the present invention have then been guaranteed.
It is major ingredient that novel external adjuvant of the present invention mainly adopts senior glue article pharmagel; The shortcoming of fundamentally avoiding substrate such as rubber, lead plaster to bring; Adopted water-soluble macromolecule (carbomer) as carrier in the prescription of substrate simultaneously; It is high molecular surfactant that employing has the inert polyvinylpyrrolidone of good physiology; Obviously improved the transdermal effect of medicine, strengthened the medical material of all kinds of forms, the pardon of extractum, for the external medication of multiple disease and the external of plant amedica provide application foundation; For convenient medical treatment, cosmetic external preparation product article provide a good operating platform.
Novel external adjuvant prestowage medicine of the present invention, the external preparation of processing is compared with administering modes such as oral, injection, transfusions has following characteristics and advantage:
1. to the local directly dispenser of patient's disease sites, targeting property is strong, and is little to the entire effect of human body, safe in utilization, reduced the danger of oral or drug administration by injection, is the medicine delivery platform with better performance, as safe as a house reliable.
2. avoided the first-pass effect of medicine, medicine is more stably directly got in blood, tissue fluid, the lymph fluid, thereby improved patient's adaptability gastrointestinal tract and liver, needn't frequent drug administration.Evident in efficacy, take effect rapidly.External preparation is treated to send out and is imposed on the part, and the medicine in the local organization is significantly higher than haemoconcentration, so play a role fully rapidly, local curative effect obviously is superior to oral medication, is fit to very much inconvenient pill taker or is reluctant that the pill taker uses.Especially particularly important to elderly patients.
3. indication is wide, and is easy to use.As long as understand the effect of common dosage forms and be suitable for card, contraindication just can be treated by applying method and requirement according to s own situation voluntarily.
4. novel external adjuvant can directly carry medicine, only need do affinity and proportioning test, can manufacture the percutaneous dosing external preparation product with special efficacy, makes it become the ideal external used medicine delivery platform of medical circle.
The external preparation cosmetics that novel external adjuvant of the present invention is processed are compared with external preparation cosmetics in the past and to be used more conveniently, and water conservation is more lasting.Via the unique slow-release function of novel external adjuvant of the present invention, can better reach its cosmetic purpose.The distinguishing feature that novel external adjuvant itself of the present invention is had:
1. it is bigger to contain dose: this adjuvant has increased the doubly thickness of above medicine layer of 4-20, and the appearance dose is significantly improved, and has strengthened the topical administration amount;
2. slow release effect is outstanding: utilize the physicochemical property of the uniqueness of gelatin, be equipped with other water-soluble macromolecule raw materials and process auxiliary material, long-time slow release drug effect fruit obviously.
3. permeability is better: rationally utilize all kinds of Material Characteristics, this auxiliary material breathability of processing in strict accordance with certain proportion, technology is better, the transdermal performance is strong, modest viscosity and can adjusting, and closer to the affinity of skin, can not produce skin stimulates.
4. viscosity is controlled, can take off subsides repeatedly: it is strong and immutable that the drawback of general traditional external preparation is that viscosity is crossed, in a single day take off during use, medicine can serious volatilization so that lost efficacy easily in the short time.Not only be prone to the adhesive tape chaeta, an also difficult maintenance and recovery viscosity continue to use.Adopt the auxiliary material of new formula development to strengthen affinity to human body skin, non-stimulated, can not produce pessimal stimulation to skin, do not pollute skin, without any side effects, easy to use, can take off subsides repeatedly, be ideal external preparation adjuvant at present.
5. the affinity of adjuvant and various medicines is better: through improved new exclusive adjuvant; For adapting to the interpolation of various medicines; Used special neutrality prescription; All having preferably newly with joint efforts and cohesion with various medicines such as assurance and water solublity and water-insoluble, acid and alkalescence, do not have any modification, is the novel auxiliary material technology platform of the multiple medicine of ideal interpolation.
The external preparation that the present invention processes the new exclusive adjuvant has carried out general stability study; Accelerated test: under integral packaging; Sample is placed in the constant temperature, constant humidity incubator of 37 ℃ of relative humiditys 75%, temperature, observes and take out sample after 3 months, measure physical behavior indexs such as its stickiness:
Inspection item standard code assay
The inspection article are randomly drawed 10% and are detected by 2000 editions appendix 1I of Chinese Pharmacopoeia
| [specification]: | 90×65×1.4±0.5CM | 90×65×1.5CM |
| [character]: | In the outward appearance is dark-brown, is outward the non-woven fabrics primary colors.The cream face should be bright and clean, thickness is even, color and luster is consistent, do not have to take off cream, lose glutinous phenomenon.Cloth cover should be smooth, and clean, nothing is leaked the cream phenomenon.The length of lid lining should be consistent with backing with width. | In the outward appearance is dark-brown, is outward the non-woven fabrics primary colors.Cream face light is bought, thickness is even, color and luster is consistent, does not have and takes off cream, the glutinous phenomenon of mistake.Cloth cover is smooth, and clean, nothing is leaked the cream phenomenon.The length of lid lining is consistent with backing with width. |
| [adhesion strength]: | The above steel ball of 13# 15 degree angles | The above steel ball of 18# 15 degree angles |
| [plastic property]: | Get test sample, put in 37 ℃, the climatic chamber of relative humidity 64 % 30 minutes, take out, with clip test sample is fixed on the smooth steel plate, the inclination angle of steel plate and horizontal plane is 60 °, places 24 hours, and the cream face should not have the trickling phenomenon | Get test sample, put in 37 ℃, the climatic chamber of relative humidity 64% 30 minutes, take out, with clip test sample is fixed on the smooth steel plate, the inclination angle of steel plate and horizontal plane is 60 °, places 24 hours, and the cream face does not have the trickling phenomenon |
| [paste containing amount]: | (100cm 2) 12.00g ± 1g | (100cm 2) 12.00 ± 0.5g |
Novel external adjuvant of the present invention has strengthened the affinity to human body skin, and pharmaceutical compositions can receive the human body skin temperature sense, in human body, permeates, and efficiency of drugs can be regulated by skin temperature, takes the back medicine off and just can stop volatilization.Can not produce skin simultaneously stimulates: through improved new exclusive adjuvant skin not being produced stimulates and toxic and side effects; And traditional external preparation is because the high dimerization material of employing is a substrate; Therefore all skin there is bigger stimulation without exception, just produces skin whiting, scratchy and erythema occurs usually after several hours.And novel external adjuvant of the present invention pastes with all non-stimulated to skin more than 7 days, and does not pollute skin, and is without any side effects.
Novel external adjuvant of the present invention is in the purposes that is used to prepare external preparation.Can be used for preparation and contain various medicated powder, extractum, extract, and the external preparation of form such as natural plant extracts.In research process, we are to multiple medicament forms, like curcuma powder, and berberine hydrochloride; Lotus-seed-heart powder, Radix Angelicae Dahuricae powder, Mentholum, Semen daturae fluid extract; Olibanum oil, Myrrha extract, Radix Et Rhizoma Rhei extract; Ginsenosides etc. experimentize, and the result shows: with the external preparation that the novel external adjuvant of the present invention is made, each side character is excellent.
The specific embodiment
For simple and purpose clearly, the omission that hereinafter is appropriate the description of known technology, in order to avoid those unnecessary details influences are to the description of present technique scheme.Below in conjunction with detecting instance the present invention is done further explanation.Wherein each kind of material all has commercially available.
Embodiment 1:
The prescription proportioning:
Glycerin 18g carbomer 1.5g gelatin 2.5g
Distilled water 15g triethanolamine 0.7g polyvinylpyrrolidone 0.5g
Methyl hydroxybenzoate 0.1g
Embodiment 2:
| Glycerin 30g | Carbomer 4g | Gelatin 4.5g |
| Distilled water 36g | Triethanolamine 2.0g | Polyvinylpyrrolidone 3g |
| Methyl hydroxybenzoate 0.6g |
Embodiment 3:
| Glycerin 25g | Carbomer 2g | Gelatin 3.5g |
| Distilled water 26g | Triethanolamine 1.2g | Polyvinylpyrrolidone 2g |
| Methyl hydroxybenzoate 0.4g |
Embodiment 4:
| Glycerin 20g | Carbomer 1.5g | Gelatin 3g |
| Distilled water 15g | Triethanolamine 1.0g | Polyvinylpyrrolidone 0.5g |
| Methyl hydroxybenzoate 0.4g |
Method for preparing:,
Get with carbomer add glycerin stir qualified after, add gelatin be stirred to mix fully the I phase; Adopt agitator to add polyvinylpyrrolidone behind the mix homogeneously mutually an amount of hot distilled water, make the II phase with I; Triethanolamine is added in an amount of distilled water, and the dissolving back adds the II phase, gets the III phase after reacting completely; Methyl hydroxybenzoate adding residue distilled water is dissolved back adding III fully promptly get this novel external adjuvant mutually.
The application of embodiment 5 novel external adjuvants aspect preparation medicine for external use woman's persona article.
Medicine for external use with the novel external adjuvant of the present invention is made is made up article; Be the excellent formation type cosmetics of long term storage stability; Can be used as to skin supply moisture, suppress evaporation, make the softish face film agent of skin or be widely used via the face film agent of skin absorbs active ingredient from the moisture of skin.As: add the medicine for external use woman's persona Semen Coicis facial film that lotus-seed-heart powder is made with the novel external adjuvant of the present invention, character is gentle, and is non-stimulated to skin.Have the natural beauty white effect, improve skin metabolism and moisture preserving function, can effectively cloudy only scaly dry skin, skin is reached fast whiten, smooth, tender effect.
Embodiment 6
Confirm whether this novel external adjuvant and products thereof has stimulation and corrosiveness and degree thereof to the mammal local skin.
One. experiment purpose:
Confirm and estimate novel external adjuvant and products thereof whether the mammal skin part is had stimulation or corrosiveness and degree thereof.
Two. material and method:
1. tried thing:
Sample is light yellow patch, and size is 5cm * 7cm, and sample is cut into 2.5cm * 2.5cm size, and is subsequent use.
2. animal and feeding environment:
Choose body weight 2.5k ~ ~ 3.0kg between, 4 of the female large ear rabbits of one-level are provided by medical experiment animal development centre, Tianjin, the quality certification number is the moving word of Tianjin doctor No. 006 0002269.Animal Lab., 20 ~ 25 ℃ of room temperatures, relative humidity 40 ~ 70%RH, the laboratory quality certification number are accurate No. 004 of the real moving facility in Tianjin.Feedstuff is provided by Tianjin China flourish laboratory animal Science and Technology Ltd..The single cage of laboratory animal is raised.
3. experimental technique:
(1) 24h is in the both sides cropping of large ear rabbit spinal column before the experiment, and baring skin, is respectively trial zone and check plot by about the skin of the about 3cm * 3cm of area respectively one.(2) before the test, the exposed skin of inspection does not have redness, breakage, can formal test.To be tried thing and sticked on the skin of unhairing of right side, covered with one deck oilpaper then, the non-stimulated immobilization with adhesive tape of reuse, sealing 4h.Left side skin is as contrast.With the warm water flush away tried behind the thing 1,24,48 and 72h observe the dermoreaction of both sides respectively, and carry out skin irritation reaction scoring and the judgement of stimulation degree by table 1 in the test of < cosmetics health standard>(version in 2007) skin irritation and table 2.
Three. the result: the integral mean value that different time is observed is 0.
Four. conclusion: this novel external adjuvant is a nonirritant to large ear rabbit acute skin irritation property.
Embodiment 7
Confirm that can this novel external adjuvant can be new adjuvant toxicity grading and tag identifier and definite subchronic toxicity test and with other toxicology test dosage foundation is provided through the toxic reaction that skin absorbs and shortterm effect is produced.
One. test objective: can confirm to be tried thing can be cosmetic material toxicity grading and tag identifier and definite subchronic toxicity test and with other toxicology test dosage foundation is provided through the toxic reaction that skin absorbs and shortterm effect is produced.
Two .1. laboratory animals:
SPF rank Wistar kind rat, body weight 200 ~ 250g is provided by institute of section of army Experimental Animal Center, and the chamber of inspection adapts to 3 days outside Animal House, and health status is good.
2. experimental animal feeding environment: feedstuff is provided by institute of section of army Experimental Animal Center, 20 ~ 25 ℃ of Animal House temperature, and relative humidity 40 ~ 70%PH, the experimental animal room quality certification number is accurate No. 003 of the real moving facility in Tianjin.
Three. tried rerum natura shape and preparation: sample is light yellow patch, and size is 5cm * 7cm, makes an experiment with raw sample.
Four. experimental technique: 10 of animal subjects, male and female half and half were tested preceding 24 hours, rejected the quilt hair at animal subject trunk back, the about 30cm * 40cm of area, inspection skin does not have breakage, carries out formal test.Sticked in back part of animal trying the dosage of thing with 5000mg/kg.BW, the contamination amount is 500mg/kg.BW, covers non-stimulated immobilization with adhesive tape, sealing contact 24h with thin film.After contamination finishes, remove the remaining thing that tried with soap water and clear water.Experimental animal ad lib, drinking-water were observed 14 days continuously.Record poisoning manifestations and death condition.
Five. result of the test:
To rat acute percutaneous toxicity test result
Do not see obvious poisoning manifestations after the animal subject contamination, do not have dead in the observation period.Each main organs is not seen obviously unusual in the postmortem.
Six. conclusion: the rat acute percutaneous toxicity LD of this novel external adjuvant
60＞5000mg/kg.BW.
The above; It only is preferred embodiment of the present invention; Be not that the present invention is done any pro forma restriction; Every foundation technical spirit of the present invention is to any simple modification, equivalent variations and modification that above embodiment did, all still belongs to novel external adjuvant and preparation method thereof in the scope of technical scheme of the present invention.
Claims (2)
1. novel external adjuvant is characterized in that it is made up of the raw material of following ratio of weight and number:
20～25 parts of glycerin, 1.5～3.5 parts of carbomers, 3～4.5 parts in gelatin, 15～30 parts of distilled water, 0.4～2.0 part of triethanolamine, 0.5～1 part of polyvinylpyrrolidone, 0.1～0.4 part of methyl hydroxybenzoate.
2. the method for preparing of the defined novel external adjuvant of claim 1 is characterized in that carrying out as follows:
(1) with carbomer add stir in the glycerin after, add gelatin be stirred to mix fully the I phase;
(2) adopt agitator to add polyvinylpyrrolidone behind the mix homogeneously mutually an amount of hot distilled water, make the II phase with I;
(3) triethanolamine is added in an amount of distilled water, the dissolving back adds the II phase, gets the III phase after reacting completely;
(4) methyl hydroxybenzoate adding residue distilled water is dissolved back adding III fully and promptly get this novel external adjuvant mutually.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1568951A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Pharmaceutical for preventing and curing acute gout, tumor and hepatic/pulmonary fibrosis and preparation method thereof |
| CN1600310A (en) * | 2003-09-22 | 2005-03-30 | 北京德众万全药物技术开发有限公司 | Combination of Liranaftate gelatin and preparation method |
| CN1743004A (en) * | 2005-10-13 | 2006-03-08 | 周旭明 | Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof |
| CN1969969A (en) * | 2006-07-20 | 2007-05-30 | 甘肃奇正藏药有限公司 | Ointment for relieving pain and diminishing swelling and preparation process thereof |
| CN101181623A (en) * | 2007-11-17 | 2008-05-21 | 甘肃奇正藏药有限公司 | Method for preparing alcohol extraction of white vein ointment |
| CN101224186A (en) * | 2008-01-23 | 2008-07-23 | 上海汇伦生命科技有限公司 | Diclofenac epolamine jellies, preparing method and uses thereof |
| CN101422585A (en) * | 2008-07-28 | 2009-05-06 | 海南碧凯药业有限公司 | Pharmaceutical use of medicine composition containing zedoary turmeric oil |
-
2009
- 2009-08-18 CN CN2009100701513A patent/CN101991858B/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1600310A (en) * | 2003-09-22 | 2005-03-30 | 北京德众万全药物技术开发有限公司 | Combination of Liranaftate gelatin and preparation method |
| CN1568951A (en) * | 2004-04-27 | 2005-01-26 | 陈明元 | Pharmaceutical for preventing and curing acute gout, tumor and hepatic/pulmonary fibrosis and preparation method thereof |
| CN1743004A (en) * | 2005-10-13 | 2006-03-08 | 周旭明 | Compound preparation for anti-pregnancy by killing sperm and sterilizing, preparation method thereof |
| CN1969969A (en) * | 2006-07-20 | 2007-05-30 | 甘肃奇正藏药有限公司 | Ointment for relieving pain and diminishing swelling and preparation process thereof |
| CN101181623A (en) * | 2007-11-17 | 2008-05-21 | 甘肃奇正藏药有限公司 | Method for preparing alcohol extraction of white vein ointment |
| CN101224186A (en) * | 2008-01-23 | 2008-07-23 | 上海汇伦生命科技有限公司 | Diclofenac epolamine jellies, preparing method and uses thereof |
| CN101422585A (en) * | 2008-07-28 | 2009-05-06 | 海南碧凯药业有限公司 | Pharmaceutical use of medicine composition containing zedoary turmeric oil |
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