CN1297251C - Hot pepper gel for treating rheumatism - Google Patents
Hot pepper gel for treating rheumatism Download PDFInfo
- Publication number
- CN1297251C CN1297251C CNB2004100649723A CN200410064972A CN1297251C CN 1297251 C CN1297251 C CN 1297251C CN B2004100649723 A CNB2004100649723 A CN B2004100649723A CN 200410064972 A CN200410064972 A CN 200410064972A CN 1297251 C CN1297251 C CN 1297251C
- Authority
- CN
- China
- Prior art keywords
- carbomer
- gel
- ethanol
- added
- hot pepper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to hot pepper gel for treating rheumatism, which comprises raw materials, such as hot pepper, menthol and borneo camphor, and auxiliary materials, such as disodium edetate dihydrate, carbomer, ethylparaben, glycerol, propanediol and ethanol. Hot peppers which are taken are pulverized; ethanol is added to the pulverized hot peppers to be heated, refluxed, extracted and filtered; the ethanol is recovered from filtrate; extract is concentrated; disodium edetate dihydrate is taken; after water is added to the disodium edetate dihydrate, and the disodium edetate dihydrate is dissolved, carbomer is added to the disodium edetate dihydrate; the disodium edetate dihydrate and the carbomer which are uniformly stirred are statically placed to obtain carbomer gel; ethylparaben, menthol, borneo camphor, propanediol and laurocapram are added to the ethanol to be uniformly sitrred with the extract; mixed liquid medicine is obtained; the mixed liquid medicine is mixed with the carbomer gel; glycerol is added to the mixture to be uniformly stirred; water is added to the mixture for preparation, namely that the hot pepper gel is obtained. The present invention has the advantages of high absorptivity, little stimulation to skin, convenient use and high stability.
Description
Technical field
The present invention relates to novel form of a kind of Chinese medicine and preparation method thereof.
Background technology
Now among the crowd, mid-aged population especially has a lot of people to suffer from various degree rheumatism, arthralgia, aching pain in waist and back, chronic arthritis etc.These diseases are perplexing people, and sufferer can not be worked normally, life.At present, be the relative medicine that raw material has been made unguentum, rubber agent, tincture at above disease with Fructus Capsici, Mentholum, Borneolum Syntheticum.Use this medicine can effectively treat above focus.But each drug form absorbability is all relatively poor, and skin is had zest, can bring discomfort to user, and use is also not too convenient.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is good to have designed absorbability, little to skin irritation, easy to use, the hot pepper gel for treating rheumatism dosage form of good stability.
The present invention is achieved by the following technical solutions:
Hot pepper gel for treating rheumatism, raw material include Fructus Capsici, Mentholum, Borneolum Syntheticum, it is characterized in that adjuvant is disodium EDTA, carbomer, ethyl hydroxybenzoate, glycerol, propylene glycol, ethanol.
Hot pepper gel for treating rheumatism, each composition weight proportioning is:
Fructus Capsici 100-400 Mentholum 20-40 Borneolum Syntheticum 20-40
Disodium EDTA 0.05-0.2 carbomer 30-50 glycerol 10-20
Ethyl hydroxybenzoate 0.5-1.5 propylene glycol 100-300 ethanol 200-500
Azone 5-25 is surplus to be suitable quantity of water
Each components total is 1000 weight portions.
Hot pepper gel for treating rheumatism, each composition weight proportioning is:
Fructus Capsici 240 Mentholums 30 Borneolum Syntheticums 30
Disodium EDTA 0.11 carbomer 45 glycerol 20
Ethyl hydroxybenzoate 1.0 propylene glycol 180 ethanol 350
It surplus the azone 20 suitable quantity of water
Each components total is 1000 weight portions.
The preparation method of hot pepper gel for treating rheumatism: get Fructus Capsici and pulverize, add 4-12 and doubly measure alcohol heating reflux, extract and filter, filtrate recycling ethanol, concentrated extract; Get disodium EDTA, after adding water and making dissolving, add carbomer, stir evenly, static, carbomer gel; Will ethyl hydroxybenzoate, Mentholum, Borneolum Syntheticum, propylene glycol, azone add in the ethanol and stir with extractum, admixing medical solutions; Admixing medical solutions is mixed with carbomer gel, add glycerol, stir evenly, add the water modulation, promptly.
The preparation method of hot pepper gel for treating rheumatism is got after Fructus Capsici pulverizes, and adds 8 times of amount alcohol heating reflux and extracts three times, and filter the back merging filtrates for three times, reclaims ethanol, makes the extractum that relative density is 1.20-1.25.
The preparation method of hot pepper gel for treating rheumatism, carbomer gel merge mixing with admixing medical solutions behind steam sterilization.
The invention has the advantages that:
(1) helps the absorption of medicine.Owing to contain certain moisture in the gel, make keratodermatitis softening, help the absorption of medicine.
(2) reduction is used comfortable to the zest of skin.Fructus Capsici easily produces burning sensation to skin, because the aquation gel layer has certain sustained release effect, thereby has alleviated because the discomfort that the intense stimulus of medicine is brought.
(3) easy to use.The closing property of Rhizoma Nelumbinis of gel and skin is better, easily is coated with exhibition, easily washing, thereby can use according to the needs massage of indication, help treatment of diseases.Especially treat chilblain, gel is easy to use than extractum.
(4) good stability.Compound recipe Fructus Capsici gel is put 40 ± 1 ℃ respectively, and in 25 ± 3 ℃ of super constant temperature troughs and 5 ± 2 ℃ of refrigerators, the temperature of simulation different regions was observed 30 days, and the result shows that viscosity of the present invention, color and luster, uniformity are all more stable, and identification experiment has no significant change.
One, pharmacological action
The main flavour of a drug of the present invention are Fructus Capsicis, its Main Ingredients and Appearance is capsaicin or claims capsaicin, external its compound capsule of using, year history surplus the preparations such as folk prescription or compound ointment agent existing 10, be widely used in treatment of diseases such as various table pain syndromes, intractable neuralgia, arthralgia and inflammation, its pharmacological action is summarized as follows:
1, analgesic activity
Human body and animal be for oral administration or local uses capsaicin to show injuring hot in nature and chemicals stimulates caused pain to have obvious mistake quick.Intrathecal injection trace capsaicin can lose the reaction to heat and chemicals stimulation for a long time.1 injection 30UG capsaicin in the rat sheath for example continues 5 months to the analgesic activity of thermostimulation.The rat skin lower injection 10mg/kg capsaicin of toe injection formaldehyde can produce significant analgesia role, rapid-action and lasting 3 hours.Capsaicin is 1.4mg/kg to the half potent analgesics amount of writhing test.Capsaicin has a significant effect to the human body skin threshold of pain, and 6 volunteer's upper arm are smeared 1% capsaicin alcoholic solution, intermittently smears 7 times to there not being local response, measures the thermostimulation threshold of pain then, decline 3.5 ℃ (anaphylaxis) in the threshold of pain in 0-10 hour.The threshold value of on average easing pain at 2-10 days rises 1.9 (analgesic activities) in addition, capsaicin only acts on the periphery afferent nerve fiber of transmission chemical stimulation, thermostimulation and the pressure receptor of peripheral sensory nerve, and the afferent nerve fiber that transmits sense of touch and mechanical stimulus is not had effect.Most of result of the tests show that the analgesic activity of capsaicin always follows the decay of some sensory nerve P-content of material.Its mechanism is different by the analgesic mechanism that suppresses prostaglandin synthetase by influence nervus centralis opiate receptor and aspirin with morphine, and most scholars think that release that it mainly passes through to influence the P-material synthesizes and stored analgesic activity.
2, antiinflammatory action
Capsaicin has significant antiinflammatory action to the joint of animal inflammation that causes with butyric, P material and antler glue.10 days posterior joints of rat knee joint inoculation punishment branch bacillus butyric begin swelling, and 18-21 days inflammation develop into summit and with inflammatory symptoms such as weight loss, growth retardations.Subcutaneous injection 20mg/kg capsaicin begins to show antiinflammatory action and continues more than 20 days after 24 hours.Rat knee joint Synovial cavity injection capsaicin 20mg/kg, 1-5 injects neuron and causes scorching Compound P-material 20ug after week, the reaction that do not cause inflammation, and matched group produces significant inflammatory reaction.Before inflammation takes place or the inflammation peak period, it is all effective to take capsaicin.In addition, capsaicin also has significant antiinflammatory action to the human body skin inflammation that causes with histamine or P-material.
3, itching-relieving action
For many years, it should be noted that pruritus and pain have confidential relation.Though pruritus and pain have common neuroanatomy approach, they have way of feeling separately.Pruritus and pain are to be transmitted by neurotransmitter P-material equally.Capsaicin may mainly act on the P-material on the C type sensory neuron, and some no marrows conduct slowly and can conduct the skin pain sensation and ill scratchiness in the C type nerve fiber.Capsaicin stops peripheroneural sensation conduction, thereby plays the effect of antipruritic.
4, antibiotic and insecticidal action
Capsaicin can significantly suppress bacillus cereus and bacillus subtilis, but invalid to staphylococcus aureus and escherichia coli.The 10%-20% decoct is killed the Cimex bedbug effect.
Two, the clinical practice of Fructus Capsici
1, treatment lumbago and skelalgia.Get cayenne pepper, vaseline (1: 1) or cayenne pepper, vaseline, flour (2: 3: 1) adds an amount of butter, the furnishing pasty state.Treat 65 examples, effective 25 examples, 23 examples that obviously take effect, transference cure 1 example, invalid 16 examples.
2, treatment wound congestive edema.Dry with Fructus Capsici and to be ground into impalpable powder, the Fan Shike by adding fusing at 1: 5 evenly stirs postcooling and is frozen into ointment, is applicable to diseases such as the subcutaneous congestive edema that causes after spraining, wound, dampening and arthralgia.Treat 12 examples, 7 example recoveries from illness, 3 routine sxs, 2 routine DeGrains.
3, diabetic neuralgia.0.075% capsaicin emulsifiable paste is treated 252 routine patients, and the back observation of 8 weeks effectively.The treatment group is compared with matched group, and the pain relief rate is respectively 69.5% and 53.4%, and pain intensity alleviates and is respectively 38.18 and 27.4%, and pain is improved and is respectively 58.4% and 45.3%.
4, post-herpetic neuralgia.External capsaicin frost or placebo treatment 32 examples, serious intractable neuropath, every day 4 times, totally 6 weeks.The result shows, patient's pain relief of treatment group 77%, and placebo group 12.5% produce burning sensation and sensation of pricking, but prolongation in time and medication and alleviate or disappear repeatedly at agents area.
5, rheumatic arthritis and arthralgia.Fructus Capsici ZHITONG GAO with 0.025% is carried out the double blinding placebo-controlled study to 101 patients.Patient's pain relief rate is respectively 57% and 33% after 4 weeks
Three, acute toxicity test
Give outside the Cavia porcellus complete sum damaged skin part and be coated with hot pepper gel for treating rheumatism maximum concentration (10 multiples that are equivalent to clinical people's consumption approximately), totally three times, observed 7 days, except that damaged skin individual animal local skin degree of taking a favourable turn flushing (be excessive concentration, dosage too big due to), do not find tangible whole body toxicity, also do not see animal dead.
Four, skin irritation test
Hot pepper gel for treating rheumatism, Porous Capsium-Plaster and gel vehicle all do not have obvious irritation to the rabbit intact skin; And Porous Capsium-Plaster to one week of damaged skin animal successive administration after, there is the moderate zest animal part, show as erythema and slightly ooze out, with local low-grade infection (after may being local Porous Capsium-Plaster, because due to the local breathability difference), although all in advance former rheumatism plaster is slowly taken off after moistening with normal saline again when changing dressings at every turn, but can not guarantee that former damaged skin is not by wound again, after each administration in 30 minutes, animal all again and again later attempts rheumatism plaster is bitten off, and restlessness, in time, scream; Although hot pepper gel for treating rheumatism also has zest to damaged skin, and is obviously lighter than Porous Capsium-Plaster group, and the part also do not ooze out and infects, and do not see the significant discomfort of animal after the administration yet.
Five, skin anaphylactic test
Be coated with three sensitization of hot pepper gel for treating rheumatism (next day once) and attacked in the 14th day after last sensitization to guinea pig back depilation district is outer, tangible skin and systemic anaphylaxis do not appear in Cavia porcellus.
Six, prescription design considerations
Select carbomer as gelatinizing agent, carbomer is the water-soluable gel material of using always, and its viscosity is moderate, low price, and its thickening property has certain mitigation to the zest of chili ingredient.
Selecting water-ethanol for use is main dicyandiamide solution, and Mentholum, Borneolum Syntheticum all are dissolved in ethanol in this product prescription, and Borneolum Syntheticum is almost insoluble in water, Mentholum soluble,very slightly in water, and the water-ethanol gel that high concentration ethanol makes is stronger to skin irritation.Therefore, under the condition of Ying Zaineng dissolving prescription drug, reduce the ethanol content in the gel as far as possible, make it to obtain stabilizing gel, little to skin irritation again.Not so good because of capsicum oleoresin dissolving situation in water-ethanol system again, find after deliberation, add propylene glycol, Fructus Capsici extract there is certain solubilization, therefore, in the design of preparation prescription, adopted water-ethanol-mixed with propylene glycol dicyandiamide solution.
Nipalgin ethanol can suppress gel effectively and grow mycete as antibacterial; Disodium EDTA has complexing as stabilizing agent to metal ion; The viscosity reduction phenomenon of gel can be effectively avoided in the adding of disodium EDTA; Glycerol has certain mitigation as heat preserving agent to zest.
Under the situation that medicament composing prescription is determined, the content of adjuvant antibacterial in the preparation basic recipe and stabilizing agent etc. is decided routinely.The optimum content of carbomer is determined with the orthonormal design of experiments result.
The specific embodiment
Embodiment 1
1, each component of medicine is:
Fructus Capsici 240g Mentholum 30g Borneolum Syntheticum 30g
Disodium EDTA 0.11g carbomer 45g glycerol 20g
Ethyl hydroxybenzoate 1.0g propylene glycol 180g ethanol 350g
Azone 20g is surplus to be suitable quantity of water
Each components total is 1000g.
2, preparation method
Get Fructus Capsici and pulverize, add 8 times of amount alcohol heating reflux and extract three times, and filter the back merging filtrate for three times, reclaim ethanol, make the extractum that relative density is 1.20-1.25; Get disodium EDTA, after adding water and making dissolving, add carbomer, stir evenly, static, carbomer gel; Will ethyl hydroxybenzoate, Mentholum, Borneolum Syntheticum, propylene glycol add in the ethanol and stir with extractum, admixing medical solutions; Admixing medical solutions is mixed with carbomer gel, add glycerol, stir evenly, add water and be modulated into 1000g, promptly.
Embodiment 2
1, each component of medicine is:
Fructus Capsici 100g Mentholum 20g Borneolum Syntheticum 20g
Disodium EDTA 0.05g carbomer 30g glycerol 10g
Ethyl hydroxybenzoate 0.5g propylene glycol 100g ethanol 200g
Azone 5g is surplus to be suitable quantity of water
Each components total is 1000g.
2, preparation method
Get Fructus Capsici and pulverize, add 8 times of amount alcohol heating reflux and extract three times, and filter the back merging filtrate for three times, reclaim ethanol, make the extractum that relative density is 1.20-1.25; Get disodium EDTA, after adding water and making dissolving, add carbomer, stir evenly, static, carbomer gel; Will ethyl hydroxybenzoate, Mentholum, Borneolum Syntheticum, propylene glycol add in the ethanol and stir with extractum, admixing medical solutions; Admixing medical solutions is mixed with carbomer gel, add glycerol, stir evenly, add water and be modulated into 1000g, promptly.
Embodiment 3
1, each component of medicine is:
Fructus Capsici 400g Mentholum 40g Borneolum Syntheticum 40g
Disodium EDTA 0.2g carbomer 50g glycerol 20g
Ethyl hydroxybenzoate 1.5g propylene glycol 300g ethanol 500g
Azone 25g is surplus to be suitable quantity of water
Each components total is 1000g.
2, preparation method
Get Fructus Capsici and pulverize, add 8 times of amount alcohol heating reflux and extract three times, and filter the back merging filtrate for three times, reclaim ethanol, make the extractum that relative density is 1.20-1.25; Get disodium EDTA, after adding water and making dissolving, add carbomer, stir evenly, static, carbomer gel; Will ethyl hydroxybenzoate, Mentholum, Borneolum Syntheticum, propylene glycol add in the ethanol and stir with extractum, admixing medical solutions; Admixing medical solutions is mixed with carbomer gel, add glycerol, stir evenly, add water and be modulated into 1000g, promptly.
Claims (2)
1, hot pepper gel for treating rheumatism, raw material include Fructus Capsici, Mentholum, Borneolum Syntheticum, it is characterized in that adjuvant is disodium EDTA, carbomer, ethyl hydroxybenzoate, glycerol, propylene glycol, ethanol, and each composition weight proportioning is:
Fructus Capsici 100-400 Mentholum 20-40 Borneolum Syntheticum 20-40
Disodium EDTA 0.05-0.2 carbomer 30-50 glycerol 10-20
Ethyl hydroxybenzoate 0.5-1.5 propylene glycol 100-300 ethanol 200-500
Azone 5-25 is surplus to be suitable quantity of water
Each components total is 1000 weight portions.
2, hot pepper gel for treating rheumatism according to claim 1 is characterized in that each composition weight proportioning is:
Fructus Capsici 240 Mentholums 30 Borneolum Syntheticums 30
Disodium EDTA 0.11 carbomer 45 glycerol 20
Ethyl hydroxybenzoate 1.0 propylene glycol 180 ethanol 350
It surplus the azone 20 suitable quantity of water
Each components total is 1000 weight portions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100649723A CN1297251C (en) | 2004-10-12 | 2004-10-12 | Hot pepper gel for treating rheumatism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100649723A CN1297251C (en) | 2004-10-12 | 2004-10-12 | Hot pepper gel for treating rheumatism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1695663A CN1695663A (en) | 2005-11-16 |
| CN1297251C true CN1297251C (en) | 2007-01-31 |
Family
ID=35348652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100649723A Expired - Fee Related CN1297251C (en) | 2004-10-12 | 2004-10-12 | Hot pepper gel for treating rheumatism |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1297251C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406565B (en) * | 2007-10-12 | 2012-03-21 | 沈阳红药制药股份有限公司 | Pepper Babu plaster for rheumatism and method for producing the same |
| CN102846842B (en) * | 2012-10-16 | 2013-11-20 | 河南中医学院 | Topical gel for treating rheumatic arthritis |
| US10918685B2 (en) * | 2017-01-05 | 2021-02-16 | Ravi Ramamoorthy Iyer | Herbal topical composition for muscle and joint health, recovery from exertion, and for pain management |
| CN107261087A (en) * | 2017-06-28 | 2017-10-20 | 王堾献 | A kind of external application of soft tissue of joint pain assistant massaging rehabilitation is pressed moxibustion and dispelled pain essential oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368125A (en) * | 2001-02-02 | 2002-09-11 | 杨孟君 | Nano medicine 'Lajiaofengshi' and its preparing process |
| CN1489990A (en) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | Preparing method for superfine Chinese medicine jellies |
| CN1520816A (en) * | 2003-01-27 | 2004-08-18 | 上海海天医药科技开发有限公司 | Sophocarpidine gel preparation and its process |
-
2004
- 2004-10-12 CN CNB2004100649723A patent/CN1297251C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1368125A (en) * | 2001-02-02 | 2002-09-11 | 杨孟君 | Nano medicine 'Lajiaofengshi' and its preparing process |
| CN1520816A (en) * | 2003-01-27 | 2004-08-18 | 上海海天医药科技开发有限公司 | Sophocarpidine gel preparation and its process |
| CN1489990A (en) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | Preparing method for superfine Chinese medicine jellies |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1695663A (en) | 2005-11-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI352597B (en) | Composition having effect of moxibustion and press | |
| CN102068474B (en) | Capparis spinosa fruit gel ointment, production method thereof, and application thereof to antirheumatic medicaments | |
| CN103961636B (en) | Orthopedic disease treatment external application traditional Chinese medicine composition, preparation method and application thereof | |
| CN1241578C (en) | Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method | |
| CN1883618A (en) | Effective parts of cirald daphne bark, preparation method and application thereof | |
| CN1679888A (en) | Decoction Chinese medicine sterilizing antiphlogistic, preparation and use thereof | |
| CN102861116B (en) | Method for preparing pericarpium granati polyphenol gel for treating gynecological inflammation | |
| CN108310339A (en) | A kind of toxin expelling clearing damp health foot patch | |
| CN101485727A (en) | External-use tinctura for treating chilblain | |
| CN1322895C (en) | Chinese medicinal gel formulation and its preparing process | |
| CN1297251C (en) | Hot pepper gel for treating rheumatism | |
| CN104984209A (en) | Improved dog skin plaster treating acute sprain and bruise, rheumatism and pain and preparing method of improved dog skin plaster | |
| CN112057585A (en) | Formula of patch containing multiple essential oils for treating pain in neck, shoulder, waist and leg and preparation method thereof | |
| CN103656025A (en) | Medicinal liquor for traumatic injuries | |
| KR20020021314A (en) | A patch using crude drugs | |
| CN102302717B (en) | Traditional Chinese medicine composition and medical pad for treating prostatic disease, and preparation method of medical pad | |
| CN103385927A (en) | Traditional Chinese medicine composition for the treatment of animal acariasis | |
| CN101095944B (en) | Sustained-releasing paster for preventing and treating prostatitis acupuncture points and the method for preparing the same and the use thereof | |
| CN100502917C (en) | Powder medicine for clearing and activating the channels and collaterals and relieving pain | |
| CN1806850A (en) | Transdermal drug delivery intensifier composition and its application in externally applied medicine | |
| CN114177160A (en) | Foot patch for treating dental ulcer and preparation method thereof | |
| CN111759905A (en) | Cataplasm for treating osteoarthritis and preparation method thereof | |
| CN101703667A (en) | Brown red medicament for treating traumatic injuries and preparation method thereof | |
| CN1251753C (en) | Externally-applied medicine composition for treating mastoproliferation and its prepn | |
| CN100402040C (en) | Pain easing pharmaceutical composition and cataplasm thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070131 Termination date: 20121012 |