CN1241578C - Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method - Google Patents
Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method Download PDFInfo
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Abstract
The present invention discloses a skin care drug having the functions of relieving itching, removing roots and toxic substances and curing tinea and a preparation method thereof. The skin care drug having the functions of relieving itching, removing roots and toxic substances and curing tinea comprises dried alum, borneol, sulfur, boric acid, camphor, calomel, hydrargyri oxydum rubrum, mercury, scorpions, centipedes, chaulmoogra, kuh-seng, croton, dahurian angelica, periostracum cicadae, bushy sophora roots, honeycombs, pseudolarix, duckweed, cantharides, fructus cnidii and broom cypress fruit. In the preparation method, the raw drugs of the dried alum, the borneol, the sulfur, the boric acid and the camphor are placed in a container and is placed in boiling water for 3 to 10 minutes; alcohol is mixed to shake up the raw drugs, and the raw drugs are made into various dose types according to a conventional preparation method of skin drugs for external use. The method also comprises the steps that the dried alum, the borneol, the sulfur, the boric acid and the camphor are soaked in the alcohol to be extracted and be filtered; the sulfur and the boric acid are added. The present invention can treat various tinea diseases, such as various psoriasis, tinea on feet and hands, tinea corporis, tinea cruris, tinea on heads and faces, tinea versicolor, etc., and various skin diseases, such as eczema of various types, dermatitis, scabies, beriberi, damp toxins, heat toxins, urticaria, prurigo, comedos, acne, flat warts, ichthyosis, shingles, etc., and has the advantages of obvious therapeutic effects, no toxic and side effects and high radical treating rates.
Description
Technical field
The present invention relates to the dermopathic medicine of a kind of treatment, relate in particular to various ringworms such as the various psoriasiss of a kind of treatment (psoriasis), tinea manus and pedis, tinea corporis and cruris, head and face tinea, tinea versicolor and all types of eczema, dermatitis, scabies, beriberi, noxious dampness, pyretic toxicity, urticaria, prurigo, acne, acne, verruca plana, ichthyosis, herpes zoster etc. dermopathic antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, fully eliminating-toxin and curing-tinea medicine and preparation method thereof.
Background technology
Dermatosiss such as all types of eczemas, dermatitis, scabies, beriberi, noxious dampness, pyretic toxicity, urticaria, prurigo, acne, acne, verruca plana, ichthyosis, herpes zoster are the common skin diseases.Psoriasis, it is a kind of common, multiple chronic skin disease, with the silvery white squama of affected part surface coverage is main levying, good sending out stretched side in scalp, trunk and extremity, it is painful unusually to get this patient, have a strong impact on normal work and study and life, psoriasis belongs to autoimmune disease, and and microcirculation disturbance interweave and be to suffer from.Fall bits once suffering from just decortication, outbreak repeatedly, touching difficulty is still one of the world's four big pertinacious diseases more so far.This disease cause of disease is unclear fully as yet so far, it is generally acknowledged relevant with multiple factors such as heredity, infection, immunity, metabolism, endocrine disturbance, spirit.At present, psoriatic treatment is mainly based on medicine, though the method for treatment is many, can only reach recent clinical effectiveness mostly, and recurrence is difficult to radical cure.Western medicine adopts 17-hydroxy-11-dehydrocorticosterone or cellular immunization inhibitor more, as bimolane, aminopterin etc., though this class medicine has short term effect preferably, but this class medicine is suppressing the synthetic while of DNA, because the dialogue cell killing is too much, and cause leukemic tragedy more and more, so forbidding or careful usefulness have been reminded.The disadvantage that they exist is epidermis and the corium attenuation that life-time service can make skin, and can cause serious toxicity such as telangiectasis and addiction, and complication is many, and subject range is little, and price is also relatively more expensive, is not the psoriatic direction of treatment.The maximum side effect of hormone then is an evolution rule of having run counter to " moving back with advancing to give up ", though can obtain the effect in a period of time, the hormonal system of its body of drug withdrawal just is in " fire extinguishing state ", is difficult to " self-reliance; ensure supply ", thereby " knock-on " phenomenon takes place.Primary disease is sunk deeper and deeper.And conventional Chinese medicine, the one, the bitter cold medicine of habitual heat-clearing and toxic substances removing is killd and is cut down yang-energy, as " Pilulae Indigo Naturalis ", though for the peak period patient of excessive noxious heat the effect in is a period of time arranged, has crossed the peak period, and the yang-energy benefit declines, with regard to unable return of spring the again.It is two in a large number with the hormone medicine surperficial inflammation that can only temporarily disappear, but old complaint still is controlled in the blood, and medicine stops soon, also can recur once again, and to external diffusion, develop immunity to drugs or drug resistance, makes the patient lose treatment confidence easily.In fact, avoiding mouth and controlling and control badly in the same old way, curing and to keep curative effect.This is because the incompatible half peppery stimulating food of institute mostly is all kinds of delicacies, nutritious product, and psoriasis is because time consuming outbreak repeatedly must cause deficiency of qi and blood.Deficiency syndrome should be treated by tonifying method, Diet cures more than the doctors, so from threpsology's angle, long-term dieting must cause the patient immune function to go from bad to worse, and is absorbed in vicious cycle.Be divided into two and see, stimulate the own benefit that stimulates, where have stimulation where have stress, where have antigen where antibody is arranged, this copingability, antibody are exactly in fact the immunity of body.According to the evolution rule that " move back with advancing to give up " biology, the immunity of body only just can strengthen in " struggle " that constantly stimulate, and the crux of the difficult radical cure of psoriasis, outbreak repeatedly promptly is this.
Other dermatosis of state's internal therapy, as dermopathic medicine for external use a multitude of names such as various ringworms such as tinea manus and pedis, tinea corporis and cruris, head and face tinea, tinea versicolor and all types of eczema, dermatitis, scabies, beriberi, noxious dampness, pyretic toxicity, urticaria, prurigo, acne, acne, verruca plana, ichthyosis, herpes zoster, as " PIYANPING ", " PIKANG SHUANG ", " PIKANGWANG ", " daktarin " or the like.But because a lot of dermatosis all is to merge fungal infection after merging bacterial infection or bacterial skin infections behind the fungal infection, and fungus or antibacterial can not be killed or suppress to above listed multiple ointment all simultaneously.For example, " PIKANGWANG " is the dermopathic synthetic plaster of a kind of treatment, its active ingredient is ketoconazole and believes his element, it still can to the ringworm effect that is caused by fungal infection, but to by bacterial, perhaps the dermatosis that is caused by fungus and antibacterial concurrent infection is as " blister tinea pedis ", and effect is not good enough; Again for example, " daktarin " is the emulsifiable paste that a kind of miconazole is made, and its anti-mycotic efficiency is very outstanding, but to because of the dermatosis of allergy or mixed infection invalid.In addition, " daktarin " do not have antipruritic analgesic effect, so to some exudative dermatosis nearly unavailables.
Summary of the invention
The purpose of this invention is to provide the dermopathic medicine of a kind of treatment, especially provide various ringworms such as the various psoriasiss of a kind of treatment (psoriasis), tinea manus and pedis, tinea corporis and cruris, head and face tinea, tinea versicolor and all types of eczema, dermatitis, scabies, beriberi, noxious dampness, pyretic toxicity, urticaria, prurigo, acne, acne, verruca plana, ichthyosis, herpes zoster etc. dermopathic antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, fully eliminating-toxin and curing-tinea medicine and preparation method thereof, it is serious to have overcome present western medicine toxicity, the shortcoming that treatment by Chinese herbs exists uncertain therapeutic efficacy to cut.
The objective of the invention is to be achieved through the following technical solutions:
A kind of antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the fully eliminating-toxin and curing-tinea medicine, comprises that following crude drug makes: dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora;
The weight portion of described crude drug is: dried Alumen 5-10, Borneolum Syntheticum 0.8-1.5, sulfur 5-8, boric acid 2-4, Camphora 1-3;
The weight portion of described crude drug is preferably: dried Alumen 7, Borneolum Syntheticum 1.2, sulfur 6, boric acid 3, Camphora 2;
Described antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the preparation method of fully eliminating-toxin and curing-tinea medicine, may further comprise the steps: get above-mentioned raw materials medicine dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora in container; Described container placed boiling water 3-10 minute; Be blended in the ethanol that concentration is 45-95%, shake up, make various dosage forms by the conventional topical agent preparation of skin method again, fill, sterilization, promptly.
Described a kind of antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the fully eliminating-toxin and curing-tinea medicine can also comprise following crude drug: Calomelas, Hydrargyri Oxydum Rubrum, hydrargyrum, Scorpio, Scolopendra, Semen Hydnocarpi, Radix Sophorae Flavescentis, Fructus Crotonis, the Radix Angelicae Dahuricae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Nidus Vespae, Cortex Pseudolaricis, Herba Spirodelae, Mylabris, Fructus Cnidii, the Fructus Kochiae;
Each parts by weight of raw materials is: Calomelas 5-10, Hydrargyri Oxydum Rubrum 3-5, Scorpio 3-5, hydrargyrum 3-5, Scolopendra 2-3, Semen Hydnocarpi 10-15, Radix Sophorae Flavescentis 10-20, Fructus Crotonis 10-15, Radix Angelicae Dahuricae 20-30, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 15-20, Nidus Vespae 6-10, Cortex Pseudolaricis 9-11, Herba Spirodelae 15-20, Mylabris 5-9, Fructus Cnidii 15-20, Fructus Kochiae 15-20;
Preferred weight part is: Calomelas 8, Hydrargyri Oxydum Rubrum 4, hydrargyrum 4, Scorpio 4, Scolopendra 2, Semen Hydnocarpi 12, Radix Sophorae Flavescentis 15, Fructus Crotonis 12, the Radix Angelicae Dahuricae 25, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 18, Nidus Vespae 8, Cortex Pseudolaricis 10, Herba Spirodelae 18, Mylabris 6, Fructus Cnidii 18, the Fructus Kochiae 18;
Described antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the preparation method of fully eliminating-toxin and curing-tinea medicine, may further comprise the steps: get above-mentioned raw materials medicine Calomelas, Hydrargyri Oxydum Rubrum, Scorpio, Scolopendra, Semen Hydnocarpi, Radix Sophorae Flavescentis, Fructus Crotonis, the Radix Angelicae Dahuricae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Nidus Vespae, Cortex Pseudolaricis, Herba Spirodelae, Mylabris, Fructus Cnidii, the Fructus Kochiae, dried Alumen, Borneolum Syntheticum, it is the container of the ethanol of 45-95% that Camphora places concentration, placed boiling water 3-10 minute, shake up, room temperature soaked 7-10 days down, filter, add sulfur, boric acid, make various dosage forms by the conventional topical agent preparation of skin method again, fill, sterilization, promptly.
Described antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the fully eliminating-toxin and curing-tinea medicine can be made into said external preparation for skin dosage form on any pharmaceutics, especially is oil preparation, Emulsion, cream, dip-coating agent, unguentum, spray, tincture, mixture, water preparation, spirit.
Described oil preparation preparation method can also be following steps: get the ratio of above-mentioned raw materials medicine in 1-2%, be blended into pure free from admixture, nontoxic, do not contain carcinogenic lubricating oil, soothing oil such as glycerol, vaseline, edible oil such as vegetable oil, Adeps Sus domestica and mineral oil, mix well fill, sterilization.
In the medicine of the present invention, Calomelas, Hydrargyri Oxydum Rubrum detoxicating and killing parasites, removing dampness is held back skin ulcer, and the row of drawing out pus by applying a plaster to the affected part is dense, removing the necrotic tissue and promoting granulation; Scorpio, Scolopendra removing obstruction in the collateral to relieve pain, detoxicating and resolving stagnation of pathogens, counteracting toxic substances is antipruritic; Semen Hydnocarpi, Radix Sophorae Flavescentis heat clearing and damp drying, detoxicating and killing parasites; The Radix Angelicae Dahuricae, Fructus Crotonis wind-expelling pain-stopping, subduing inflammation, the detumescence of relieving oedema or abdominal distension through diuresis or purgation, scabies, Pruritus are controlled in external; The Periostracum Cicadae wind heat of loosing, rash is antipruritic, relieving the exterior syndrome by diaphoresis, inducing diuresis to remove edema; Radix Sophorae Tonkinensis is separated pyretic toxicity the most very; Nidus Vespae, the auxiliary detoxicating and killing parasites of Cortex Pseudolaricis, wind-expelling pain-stopping, eliminating damp-heat; Mylabris is assisted Fructus Crotonis counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation; Fructus Cnidii, Fructus Kochiae removing damp to relieve itching; Sulfur detoxifcation parasite killing, it is antipruritic to treat skin ulcer; The Radix Sophorae Tonkinensis heat that disappears is ended the tinea skin ulcer; Borneolum Syntheticum, the auxiliary all medicine clearing away heat and cooling blood of Camphora, dispelling wind for relieving itching, back chipping is drawn out pus by applying a plaster to the affected part, counteracting toxic substances, the parasite removing virus killing, removing heat from blood, change tinea, the granulation promoting removing dampness, sterilization, skin whitening, and promote the venation microcirculation to be beneficial to effects such as Transdermal absorption, the various skin disease there is therapeutical effect.
The present invention has the following advantages:
1, is broad spectrum antibiotic, medicine-feeding is closed and is gathered, evident in efficacy to treating dermatosiss such as various ringworms such as various psoriasiss (psoriasis), tinea manus and pedis, tinea corporis and cruris, head and face tinea, tinea versicolor and all types of eczema, dermatitis, scabies, beriberi, noxious dampness, pyretic toxicity, urticaria, prurigo, acne, acne, verruca plana, ichthyosis, herpes zoster, have effect antipruritic, the tinea of sterilizing, disappear.
2, short treating period, instant effect has no side effect, and is gentle non-stimulated, this product energy strengthening vital QI to eliminate pathogenic factors, giving consideration to both the incidental and fundamental makes patient's rehabilitation and keeps stable, and relapse rate is low.
3, need not cooperate by other medicines, can control mixed infection well, can suppress or kill fungus and antibacterial simultaneously, allergy or mixed infection there is original effect, very definite to exudative strong chronic eczema curative effect, it can reduce oozing out of skin histology liquid rapidly, and the property of medicine is stronger, be difficult for forming drug resistance, can thoroughly cure the dermatosis of various stubbornnesses.
For proving above-mentioned effect of the present invention, carry out following zoopery and clinical trial:
One, to the observation of curative effect of psoriasis (psoriasis)
1, trial drug: (done adjustment according to former concentration, the present invention is the beautiful skin medicine of dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora composition for 1 group to the former medicine of medicine of the present invention; The present invention is the beautiful skin medicine of dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora, Calomelas, Hydrargyri Oxydum Rubrum, hydrargyrum, Scorpio, Scolopendra, Semen Hydnocarpi, Radix Sophorae Flavescentis, Fructus Crotonis, the Radix Angelicae Dahuricae, Periostracum Cicadae, Radix Sophorae Tonkinensis, Nidus Vespae, Cortex Pseudolaricis, Herba Spirodelae, Mylabris, Fructus Cnidii, Fructus Kochiae composition for 1 group; Below each zoopery with), the contrast test medicine: methotrexate, produce lot number: 001012 by Shanghai Lian Hua drugmaker; Levamisole is produced lot number: 000716 by Hefei pharmaceutical factory.
2, pilot project:
The influence that medicine of the present invention forms mouse tail scale granular layer.
Medicine of the present invention is to the mitotic influence of mouse vagina epithelial cell.
Medicine of the present invention is to the mitotic influence of rat vagina epithelial cell.
Ji thing of the present invention is to the influence of mouse immune organ childhood.
Test objective: observe medicine of the present invention and provide experimental basis to clinical its treatment psoriasis of the relevant main pharmacodynamics influence checking of curing psoriasis.
3, animal subject: ICR strain mice, SD strain rat, Provincial Medicine Research Institute, Anhui Experimental Animal Center provides.
4, test method and result:
1. medicine of the present invention is a mice to the ICR that influences that mouse tail scale granular layer forms, body weight 22-24g, male and female half and half.Be divided into 4 groups at random, the 1st group is the ordinary water matched group, and the 2nd group is the methotrexate positive controls, and the 3rd and 4 group is respectively medicine 0.35g/kg of the present invention and 0.47g/kg.The 1st group of mouse gavaging ordinary water, the the 3rd and 4 group of mouse stomach administration, once a day, continuous 7 days, the 2nd group of mice used methotrexate 1mg/kg intraperitoneal injection, be administered once every other day, next day is put to death mice in last administration, and it is rectangular apart from root of the tail about 2cm place back side skin one to get afterbody, use 11% formalin fixed, paraffin embedding, HE dyes, and observes the afterbody scale of every mice under light microscopic one by one.The granular layer cell person that every scale has connection to embark on journey is called the scale that granular layer is arranged.Count the scale number that granular layer is arranged in per 100 scales, statistical procedures is carried out in the t check between administration group and matched group.
Experimental result: medicine 0.35g/kg of the present invention and 0.47g/kg all can significantly improve mouse tail scale granular layer and form number (P＜0.01).Experimental result sees Table 1.
Table 1 medicine of the present invention forms mouse tail scale granular layer to be influenced (X ± S)
In per 100 scales of group dosage (g/kg) Mus tail granular layer rate of change (%) is arranged
The scale number
Ordinary water contrast-6.8 ± 0.45
Methotrexate 1mg/kg.ip 9.12 ± 1.61
*29.82
1 group 0.35 9.56 ± 1.05 of medicine of the present invention
*28.10
2 group 0.47 9.86 ± 1.57 of medicine of the present invention
*29.23
Annotate: n=10, compare * * P＜0.01 with ordinary water.
2. medicine of the present invention is to the mitotic influence of mouse vagina epithelial cell.ICR is a mice, body weight 20-24g, be divided into 4 groups at random, first group is the ordinary water matched group, and the 2nd group is the methotrexate positive controls, and the 3rd and 4 group is respectively medicine 0.35g/kg of the present invention and the 1st group of mouse gavaging ordinary water of 0.47g/kg, the the 3rd and 4 group of mouse stomach administration, every day 1 time, continuous 7 days, the 2nd group of mice methotrexate 1mg/kg intraperitoneal injection.1st, 3 and 4 groups of mice self administration of medication beginning in preceding 3 days, mouse peritoneal injection every day diethylstilbestrol 0.2mg, once a day, continuous three days.The 2nd group of injected in mice diethylstilbestrol begins lumbar injection methotrexate 1mg/kg after three days, once a day, and continuous three days.Last administration is unified in 8:30 in the morning, the morning 10:00 lumbar injection colchicine 2mg/kg, afternoon, 2:00 put to death mice, get the vagina specimen with 11% formalin fixed, paraffin embedding, HE dyeing, om observation epithelial cell mitosis, count the mitosis number of 500 basal cells, be converted to the mitosis number of per 100 basal cells, be called mitotic index.Statistical procedures is carried out in the t check between administration group and matched group.
Experimental result: medicine 0.35g/kg of the present invention and 0.47g/kg can significantly reduce estrogen phase mouse vagina epithelial cell mitotic index (P＜0.01).Result of the test sees Table 2.
Table 2 medicine of the present invention is to the mitotic influence of mouse vagina epithelial cell (X ± S)
Group dosage (g/kg) vaginal epithelial cell mitotic index rate of change (%)
Ordinary water contrast-12.07 ± 0.80
Methotrexate 1mg/kg.ip 11.14 ± 1.01
*13.00
1 group 0.35 8.16 ± 1.85 of medicine of the present invention
*28.10
2 group 0.47 4.82 ± 1.21 of medicine of the present invention
*29.23
Annotate: n=10, compare * * P＜0.01 with ordinary water.
3. medicine of the present invention is to the mitotic influence of rat vagina epithelial cell.SD is a rat, body weight 180-200g.Be divided into 4 groups at random, the 1st group is the ordinary water matched group, and the 2nd group is the methotrexate group, and the 3rd, the 4th group is respectively medicine 0.35g/kg of the present invention, 0.25g/kg administration group.Experimental technique is same 2., but diethylstilbestrol dosage is 1mg/, and colchicine dosage is 1.4mg/kg, experimental result: medicine 0.35g/kg of the present invention, 0.25g/kg all can significantly reduce estrogen phase rat vagina epithelial cell mitotic index (P＜0.01).Result of the test sees Table 3.
Table 3 medicine of the present invention is to the mitotic influence of mouse vagina epithelial cell (X ± S)
Group dosage (g/kg) vaginal epithelial cell mitotic index rate of change (%)
Ordinary water contrast-16.20 ± 0.57
Methotrexate 1mg/kg.ip 10.22 ± 1.09
*39.20
1 group 0.35 9.71 ± 1.09 of medicine of the present invention
*24.11
2 group 0.25 10.82 ± 0.61 of medicine of the present invention
*25.30
Annotate: n=10, compare * * P＜0.01 with ordinary water.
5, the conclusion Pharmacodynamic test of active extract shows, medicine of the present invention can significantly improve mouse tail scale granular layer and form, can significantly suppress estrogen phase rat and mouse vagina epithelial cell mitosis, propose it and have the parakeratosis of correction and antimitotic effect, the psoriasis experimental animal model is had obvious pharmacological significance.Therefore Drug therapy psoriasis of the present invention has its experimental basis.
Two, to tinea, itching relieving observation of curative effect
1. ointment of the present invention is observed itching-relieving action and is selected 50 of body weight 200-250g Cavia porcelluss for use, is divided into 5 groups at random, is respectively 2 groups of ointment of the present invention, press 0.16g/ foot and 0.4g/ foot coating, 1 group of ointment base of the present invention is pressed the coating of 0.4g/ foot, 1 group of anthralin ointment is pressed 0.4g/ foot coating; Contrast 1 group, be not coated with any medicine.
Earlier with the right foot depilation of each Mus, distinguish coating once subsequently, next day with each Mus depilation place with sand paper scratch but till not hemorrhage to sepage is arranged, and then coating once, after 10 minutes, 0.01% 0.05ml/ of histamine phosphate foot is dripped in beginning at the wound surface place, after this complied with 0.01,0.02%, 0.03% every 3 minutes ... progressive concentration, all drip the 0.05ml/ foot at every turn, later lick site of injury until Cavia porcellus occurring, and be itch-threshold with the histamine phosphate's total amount that occurs at last being given when Cavia porcellus later licks foot, record and itch-threshold of each group relatively.The results are shown in Table 4, can significantly improve the itch-threshold to Cavia porcellus, show that it has tangible itching-relieving action by histamine phosphate by the visible ointment of the present invention of table.
Table 4
Group dosage (g/ foot) number of animals (only) itch-threshold
1 group 0.16 10 160.00 ± 126.58* of ointment of the present invention
Ointment 2 0.4 10 289.34 ± 121.00** of the present invention
Anthralin ointment 0.4 10 178.12 ± 132.01*
Ointment base 0.4 10 32.27 ± 19.13 of the present invention
Contrast/10 34.61 ± 20.34
Annotate: compare with matched group: * * P＜0.01, * P＜0.05.
2. to tinea disease clinical case efficacy analysis
From JIUYUE to 2002 year July calendar year 2001, treat various skin ringworm 410 examples, wherein male 281 examples, women 129 examples altogether in Linquan County, Anhui hospital dermatology department out-patient department.
Using method: cleaning skin, embrocate this medicine on the surface, affected part, every day 2-3 time, 7 days is a course of treatment.
Curative effect judging standard: 1. clinical cure: the pruritus of skin ringworm, desquamation decortication, disappearances of chapping, skin color recovers normally; 2. produce effects: the chapping of skin ringworm, desquamation decortication disappear, and still have skin pruritus; 2. take a turn for the better: the disappearance of chapping of skin ringworm, the desquamation decortication alleviates. still have pruritus; 4. invalid: nothing is clearly better after the medication; 5. recurrence: continuous use is end-of-dose failure after 2 months.Observation shows that only 1% patient has slight anasarca, disappears after 5-7 days or after the drug withdrawal, does not influence treatment, and idol has 5 cases with irritated asthma, and withdrawal symptom disappears.
Table 5 Drug therapy tinea of the present invention disease efficacy analysis
The produce effects of the curing name of disease example number invalid effective percentage recurrence relapse rate that takes a turn for the better
(%) (people) (%) for (people) (people) (people) (people) (people)
Tinea pedis 251 181 60 10 0 100 26 14
The tinea manuum 60 32 21 70 100 12 20
Tinea corporis and cruris 27 24 210 100 3 11
Tinea capitis 24 18 330 100 4 17
Three, to the skin antiinflammatory action
Experimentation
Material: culture medium, bouillon agar
Strain: staphylococcus aureus, Bacillus typhi, escherichia coli, bacillus pyocyaneus all are that Anhui medical college microorganism teaching and research room preserves strain.
Medicine: tincture of the present invention; Gentamicin injection liquid is produced by Anhui pharmaceutical factory.
Animal: rabbit is provided by Anhui Province's blood institute Experimental Animal Center.
6 hours meat soup bacterium liquid of cultivation is got in the antibacterium test, and (bacterial population is 900,000,000/mL), and Sterile Saline is diluted to 1/500.Get 50 aseptic plates of diameter 9cm, add four kinds of dilution bacterium liquid 1mL respectively, pour into then and dissolve the agar culture medium 30ml that is chilled to 45 ℃, rotate mixing immediately.After solidifying, on flat board, make a call to 5 holes with external diameter 60mm sterilization glass-tube, and take out agar in the hole.Add 75% ethanol, gentamicin injection liquid, 100% stock solution medicament of the present invention in 6 holes respectively, and 1.5% medicament of the present invention (1: 60 diluent) and 0.75% medicament of the present invention (1:: each 100uL 120 diluents).Cultivated 24 hours in 37 ℃ of incubators, measure inhibition zone.By table 6 visible 100%, 1.5% and 0.75% medicament of the present invention all has tangible bacteriostasis to golden Portugal bacterium, Bacillus typhi, escherichia coli, bacillus pyocyaneus, and this effect is all greater than 75% ethanol, and composition and 75% ethanol have antibiotic synergism among prompting the present invention.From table, it can also be seen that its stock solution to the antibacterial action of green axil bacillus and golden Portugal bacterium all greater than gentamicin injection liquid. this may be the present invention to burn, scald the eutherapeutic theoretical foundation of back traumatic infection.
Four, the skin irritation experimental rabbits is 26, body weight 2-3kg, male and female half and half.Be divided into five groups at random.The I group is with 75% alcohol rub rabbit, two ears; The II group is embrocated rabbit two ears with gentamicin injection liquid; The III group is embrocated rabbit two ears with stock solution of the present invention; The IV group is embrocated rabbit two ears with 1.5% the present invention; The V group is embrocated rabbit two ears with 0.75% the present invention.Observe and write down two ear skins and have or not skin irritation phenomenons such as erythema, edema.
Result of the test is found, except that the sulphuric acid injection liquid of gentamicin does not have any skin irritation symptom, of short duration erythema appears in all the same with the 75% ethanol rabbit ear that causes with 0.75% concentration of stock solution 1.5% of the present invention, but there are not edema, no blister, erythema disappears after one hour, and this may be to spill due to the smart vasodilative effect.Prompting the present invention does not have tangible skin irritation.
Show that from the result of above pharmacodynamic study and clinical observation the present invention has the epithelial mitotic effect of significant inhibition mouse vagina; Can obviously increase the scale that has granular layer to form in the rat tails skin scale; Can significantly improve the itch-threshold to Cavia porcellus, show to have significant itching-relieving action by histamine phosphate.Above-mentioned result of study confirms that the present invention has the reduction of significant promotion cutin, antiinflammatory and bacteriostasis; Safety non-toxic of the present invention.
Case 1: the Wang, the man, 45 years old, there were the one 15 centimeters red mound of circle speckles at preceding arm place, scrapes the desquamation of itching, and red damaged, it is invalid to cure for a long time.Use medicine of the present invention recovery from illness in 15 days, skin surface is smooth, and color is with identical on every side, and healing did not have bounce-back in back 3 months.
Case 2: Liu, the man, 27 years old, tinea cruris was very itched desquamation for many years, influences orthobiosis.Be coated with and use medicine of the present invention 24 days, the desquamation transference cure of scratching where it itches, the colour of skin to recover normal, no vestige does not have repeatedly so far.
Case 3: Zhu, the woman, 57 years old, suffer from surplus the psoriasis ten year, clinical symptoms be head, hands white macula, during use multiple treatment way, medicine is produced dependency, use this medicine to alleviate, drug withdrawal did not have and recurs in 1 year.
The specific embodiment
Embodiment 1
Oil preparation
Take by weighing each component (kg) by following proportioning: dried Alumen 7, Borneolum Syntheticum 1.2, sulfur 6, boric acid 3, Camphora 2.
Preparation method, may further comprise the steps: get above-mentioned raw materials medicine porphyrize altogether, cross 20 orders, ratio in 2% be blended into pure free from admixture, nontoxic, do not contain No. 1 38.4kg of lubricating oil that carcinogenic base oil composition is mainly alkyl sodium salicylate, mix well, fill, 100ml/ props up, and 100 ℃ of steam sterilizations promptly got the dip-coating agent in 20 minutes.
Embodiment 2
Oil preparation
Take by weighing each component (kg) by following proportioning: dried Alumen 6, Borneolum Syntheticum 1.3, sulfur 7, boric acid 4, Camphora 1.
Preparation method may further comprise the steps: get above-mentioned raw materials medicine porphyrize altogether, cross 20 orders, the ratio in 1% is blended into purified Adeps Sus domestica 38.4kg, mix well, and fill, 100ml/ props up, and 100 ℃ of steam sterilizations promptly got the dip-coating agent in 15 minutes.
Embodiment 3
The dip-coating agent
Take by weighing each component (kg) by following proportioning: dried Alumen 7, Borneolum Syntheticum 1.2, sulfur 6, boric acid 3, Camphora 2.
Preparation method may further comprise the steps: get above-mentioned raw materials medicine dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora in container; Described container placed boiling water 10 minutes; Be blended into concentration and be in 50% the ethanol and make 100L, shake up, fill, 100 ℃ of steam sterilizations promptly got the dip-coating agent in 20 minutes.
Embodiment 4
Tincture
Take by weighing each component (kg) by following proportioning: dried Alumen 10, Borneolum Syntheticum 1.5, sulfur 8, boric acid 4, Camphora 3.
Preparation method may further comprise the steps: get above-mentioned raw materials medicine dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora in container; Described container placed boiling water 6 minutes; Be blended into concentration and be in 80% the ethanol, add 40L ethanol, 20L propylene glycol, the formulated tincture 100L of 10L glycerol and surplus distilled water.
Embodiment 5
Unguentum
Take by weighing each component (kg) by following proportioning: dried Alumen 5, Borneolum Syntheticum 0.8, sulfur 5, boric acid 2, Camphora 1.
Preparation method may further comprise the steps: get above-mentioned raw materials medicine dried Alumen, Borneolum Syntheticum, sulfur, boric acid, Camphora in container; Described container placed boiling water 5 minutes; Be blended into concentration and be in 45% the ethanol, add excipient octadecanol 4kg, stearic acid 8kg, glyceryl monostearate 5kg, vaseline 6kg, glycerol 10kg, triethanolamine 0.8kg and surplus distilled water are mixed with unguentum, fill, 10 grams/, 100 ℃ of steam sterilizations 15 minutes are promptly.
Embodiment 6
Oil preparation
Take by weighing each component (kg) by following proportioning: dried Alumen 5, Borneolum Syntheticum 0.8, sulfur 5, boric acid 2, Camphora 1, Calomelas 8, Hydrargyri Oxydum Rubrum 4, hydrargyrum 3.5, Scorpio 4, Scolopendra 2, Semen Hydnocarpi 12, Radix Sophorae Flavescentis 15, Fructus Crotonis 12, the Radix Angelicae Dahuricae 25, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 18, Nidus Vespae 8, Cortex Pseudolaricis 10, Herba Spirodelae 18, Mylabris 6, Fructus Cnidii 18, the Fructus Kochiae 18.
Preparation method may further comprise the steps: get the above-mentioned raw materials medicine, altogether porphyrize is crossed 200 orders, adds glycerol 6kg, and adding distil water is made 100L, shakes up, and fill 125ml/ bottle, 100 ℃ of steam sterilizations 20 minutes are promptly.
Embodiment 7
Spray
Take by weighing each component (kg) by following proportioning: dried Alumen 5, Borneolum Syntheticum 0.8, sulfur 5, boric acid 2, Camphora 1, Calomelas 8, Hydrargyri Oxydum Rubrum 4, hydrargyrum 4, Scorpio 4, Scolopendra 2, Semen Hydnocarpi 12, Radix Sophorae Flavescentis 15, Fructus Crotonis 12, the Radix Angelicae Dahuricae 25, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 18, Nidus Vespae 8, Cortex Pseudolaricis 10, Herba Spirodelae 18, Mylabris 6, Fructus Cnidii 18, the Fructus Kochiae 18.
Preparation method may further comprise the steps: getting the above-mentioned raw materials medicine is in the container of 65% ethanol in concentration, places boiling water 10 minutes; Room temperature soaked 8 days down, filtered, and filtrate adds sulfur, boric acid, and adding distil water is made 100L, shook up, and fill spray bottle, 100 ℃ of steam sterilizations 20 minutes are promptly.
Embodiment 8
Tincture
Take by weighing each component (kg) by following proportioning: dried Alumen 10, Borneolum Syntheticum 1.5, sulfur 8, boric acid 4, Camphora 3, Calomelas 5, Hydrargyri Oxydum Rubrum 3, hydrargyrum 3, Scorpio 3, Scolopendra 2, Semen Hydnocarpi 10, Radix Sophorae Flavescentis 10, Fructus Crotonis 10, the Radix Angelicae Dahuricae 20, Periostracum Cicadae 12, Radix Sophorae Tonkinensis 15, Nidus Vespae 6, Cortex Pseudolaricis 9, Herba Spirodelae 15, Mylabris 5, Fructus Cnidii 15, the Fructus Kochiae 15.
Preparation method may further comprise the steps: get the above-mentioned raw materials medicine in the container that in concentration is 50% ethanol, placed boiling water 6 minutes; Room temperature soaked 7 days down, filtered, and filtrate adds sulfur, boric acid, adds 30L ethanol, 10L propylene glycol, the formulated tincture 100L of 8L glycerol and surplus distilled water.
Embodiment 9
Unguentum
Take by weighing each component (kg) by following proportioning: dried Alumen 5, Borneolum Syntheticum 0.8, sulfur 5, boric acid 2, Camphora 1, Calomelas 10, Hydrargyri Oxydum Rubrum 5, hydrargyrum 5, Scorpio 5, Scolopendra 3, Semen Hydnocarpi 15, Radix Sophorae Flavescentis 20, Fructus Crotonis 15, the Radix Angelicae Dahuricae 30, Periostracum Cicadae 20, Radix Sophorae Tonkinensis 20, Nidus Vespae 10, Cortex Pseudolaricis 11, Herba Spirodelae 20, Mylabris 9, Fructus Cnidii 20, the Fructus Kochiae 20.
Preparation method may further comprise the steps: getting the above-mentioned raw materials medicine is in the container of 65% ethanol in concentration,, placed boiling water 10 minutes; Room temperature soaked 10 days down, filtered, and the thick shape of filtrate simmer down to adds sulfur, boric acid; Add excipient octadecanol 3kg, stearic acid 4kg, glyceryl monostearate 3kg, vaseline 4kg, glycerol 8kg, triethanolamine 0.2kg and surplus distilled water are mixed with unguentum, fill, and 10 grams/, 100 ℃ of steam sterilizations 15 minutes are promptly.
Claims (8)
1, a kind of antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the external used medicine of fully eliminating-toxin and curing-tinea, it is characterized in that by comprising that following bulk drugs makes: dried Alumen 5-10, Borneolum Syntheticum 0.8-1.5, sulfur 5-8, boric acid 2-4 and Camphora 1-3.
2, according to antipruritic, the back chipping of claim 1 draw out pus by applying a plaster to the affected part, the external used medicine of fully eliminating-toxin and curing-tinea, it is characterized in that the weight portion of each crude drug is: dried Alumen 7, Borneolum Syntheticum 1.2, sulfur 6, boric acid 3 and Camphora 2.
3, a kind of antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the external used medicine preparation method of fully eliminating-toxin and curing-tinea, may further comprise the steps: the weighting profit requires 1 or 2 described components in container; Described container placed boiling water 3-10 minute; Be blended in the ethanol that concentration is 45-95%, shake up, make various dosage forms by the conventional topical agent preparation of skin method again.
4, according to claim 3 antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the external used medicine preparation method of fully eliminating-toxin and curing-tinea, further comprising the steps of: the weighting profit requires the ratio of 1 or 2 crude drug in 1-2%, be blended into pure free from admixture, nontoxic, do not contain in carcinogenic lubricating oil, soothing oil, edible oil, the mineral oil any one or more, mix well, fill, sterilization promptly gets oil preparation.
5, according to the external used medicine of claim 1, it is characterized in that also containing following bulk drugs: Calomelas 5-10, Hydrargyri Oxydum Rubrum 3-5, hydrargyrum 3-5, Scorpio 3-5, Scolopendra 2-3, Semen Hydnocarpi 10-15, Radix Sophorae Flavescentis 10-20, Fructus Crotonis 10-15, Radix Angelicae Dahuricae 20-30, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 15-20, Nidus Vespae 6-10, Cortex Pseudolaricis 9-11, Herba Spirodelae 15-20, Mylabris 5-9, Fructus Cnidii 15-20 and Fructus Kochiae 15-20.
6, according to the external used medicine of claim 5, it is characterized in that the weight portion of each crude drug is: dried Alumen 7, Borneolum Syntheticum 1.2, sulfur 6, boric acid 3, Camphora 2, Calomelas 8, Hydrargyri Oxydum Rubrum 4, hydrargyrum 4, Scorpio 4, Scolopendra 2, Semen Hydnocarpi 12, Radix Sophorae Flavescentis 15, Fructus Crotonis 12, the Radix Angelicae Dahuricae 25, Periostracum Cicadae 12-20, Radix Sophorae Tonkinensis 18, Nidus Vespae 8, Cortex Pseudolaricis 10, Herba Spirodelae 18, Mylabris 6, Fructus Cnidii 18 and the Fructus Kochiae 18.
7, a kind of antipruritic, back chipping is drawn out pus by applying a plaster to the affected part, the preparation method of the external used medicine of fully eliminating-toxin and curing-tinea, may further comprise the steps: the weighting profit requires the ratio of 5 or 6 crude drug in 1-2%, be blended into pure free from admixture, nontoxic, do not contain in carcinogenic lubricating oil, soothing oil, edible oil or the mineral oil any one or more, mix well, fill, sterilization promptly gets oil preparation.
8, according to antipruritic, the back chipping of claim 1 draw out pus by applying a plaster to the affected part, the external used medicine of fully eliminating-toxin and curing-tinea, described medicine is oil preparation, Emulsion, cream, dip-coating agent, unguentum, spray, tincture, mixture, water preparation or spirit.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03150196 CN1241578C (en) | 2003-07-22 | 2003-07-22 | Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method |
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| CN 03150196 CN1241578C (en) | 2003-07-22 | 2003-07-22 | Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method |
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| CN101933997B (en) * | 2010-09-29 | 2011-11-30 | 李婷 | Compound anti-inflammatory antipruritic ointment |
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