CN105560292A - Drug capable of killing herpes simplex virus and chicken pox-herpes zoster virus - Google Patents
Drug capable of killing herpes simplex virus and chicken pox-herpes zoster virus Download PDFInfo
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Abstract
The invention provides a drug capable of killing a herpes simplex virus and a chicken pox-herpes zoster virus. The drug is at least prepared from, by weight, 10-100 parts of ethyl alcohol and 0.1-1 part of Chinese blister beetles. The drug has a remarkable prevention and control effect on the herpes simplex virus and the chicken pox-herpes zoster virus and obtains unexpected effects in long-term and short-term clinical treatment, and untoward effects, toxic and side effects and postherpetic neuralgia of a patient are not found.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of medicine killing herpes simplex virus and varicella zoster virus.
Background technology
The sexually transmitted disease (STD) that genital herpes causes primarily of herpes simplex virus (HSV), also known as pudendum (genitals) herpes.Mainly being present in the place such as penis, urethra of women's cervix uteri, vagina, skin of vulva and male, is the arch-criminal causing genitals inflammation herpes.Abroad, its sickness rate is only second to gonorrhea and syphilis in sexually transmitted disease (STD), occupies the 3rd of sexually transmitted disease (STD) sickness rate, holds pride of place in the sexually transmitted disease (STD) caused by virus.The mankind are unique natural reservoir (of bird flu viruses) of herpes simplex virus, and crowd infection rate, up to 80-90%, wherein about has the patient of 10% asymptomatic.Show according to authoritative data, annual newly-increased herpes patient 1,800,000 people of China, canceration rate, 0.93%, namely has 1.6 ten thousand patients to face canceration every year.
In Chinese society, along with world development, open-minded, the infiltration of Western Culture idea, the attitude towards sex also opening gradually of increasing people, has become the best soil and hotbed that grow sexually transmitted disease (STD).Discussed that China's infectiousness is the strongest, sexually transmitted disease (STD) that cure rate is one of minimum, genital herpes is undisputed outstanding person.
Data display according to the relevent statistics, genital herpes is after sexual organ's contact, hide about 2-20 days (average 6 days), there are immunodeficiency or immunoincompetent people, rear exacerbation of symptoms is infected as applied immunosuppressant, renal transplantation, serious burn, severe malnutrition, blood-lymphatic system malignant tumor patient etc., eczema herpeticum, recurrent corneal ulcer can be there is, even whole body disseminated herpes and fatal.Produce neutralizing antibody and complement fixation antibody in body after infecting 1-3 week, remaining virus neurally towards periphery may proceed to trigeminal ganglion or sacral ganglia along neuraxon, and hides for a long time, enters resting state.
Investigation shows: inside the female population that socioeconomic status is lower, and intravaginal herpesvirus discharge rate is 0.4-1.33%.Someone does when reproductive tract check one group of prostitute and finds, the discharge rate of herpesvirus unexpectedly up to 12%, and nearly the prostitute of 70% all with herpesvirus.Prove that its generation has contacted direct relation with property.Primary disease infectiousness is extremely strong, and the disposable women contacted occurs all male with suffering from herpes of penis, about has 60-80% to be infected.To this, many scholars think that the morbidity of cervical cancer and carcinoma of penis and viral infection of genital herpes have substantial connection.
Why genital herpes makes us hearing and complexion changed, and mainly because it has stronger infectiousness, pathogenicity rate is high, becomes a kind of general sexually transmitted disease (STD).This virus can be survived a few hours in a humid environment, by pollutant infect indirectly; Again because it is also infectious in incubation period, so people can be allowed under involuntary situation to become propagation and victim.It both passability contagion to spouse or other sex partner, homosexual person; Infect neonate by Placenta Hominis and birth canal, cause fetal abortion and neonatal death; Also can suffer from the people of herpes around direct oral cavity or oral cavity, pass through oral cavity---genitals sexual intercourse, makes the other side infect genital herpes.Show according to another data, also can be infected when autoimmune is poor Yu by the article contacts that genital herpes pollutes, as the approach also easy infected anogenital herpes such as use hotel contaminated bedding, bath in a tub, sauna bath, bath in hot spring.The i.e. sexual behaviour of different modes, all can propagate genital herpes disease.In recent years, worldwide, the number of patients of genital herpes constantly increases, and particularly in the active crowd of property, about have the people of 30% to suffer from genital herpes, especially in adolescence, the sickness rate of this disease is even also high than gonorrhea.
AUTHORITATIVE DATA according to China Health organisations publish shows, China annual new infections genital herpes virus patient 1,800,000 people, and cure less than 100,000, become the another large sexually transmitted disease (STD) after being only second to acquired immune deficiency syndrome (AIDS).Due to the disease that it is a kind of stubbornness, be difficult to radical cure, lack specific short and medicine always and it is felt simply helpless, therefore, primary disease is in fact becoming a kind of incurable disease that can not be cured, stubbornly refused, its hazardness is quite large, not only bring uncomfortable to patient, long-term stress, also be easy to cause male patient to occur as while sexual impotence, prostatitis, a series of complication such as sterile, there is provided passage and convenience for HIV (human immunodeficiency virus) enters in body again, thus add the danger suffering from acquired immune deficiency syndrome (AIDS).The particularly feature of its frequent recurrence, patient will take higher medical expense every year.Along with the growth of annual kainogenesis patient, it is medical expense also linearly propradation for each person, and the huge rising directly causing national health-care hospital welfare to be paid, causes the waste that state's financial capacity is unnecessary, directly affects income and the benefit of gross national product.Be in helpless in patient, be also often forced to select and credulous those are turned on the medical institutions of radical cure banner fast, result, the money of patient and his family is without restraint robbed and is obtained by cheating, causes the massive losses that national economy is taken in.
Furtherly: herpes simplex virus is that a kind of neurocyte infects disease and has very large infectiousness, and it can destroy the normal operation of human body parts nervous system, causes many nervous system malaise symptoms and has disguise and recurrent.His complication is very serious, can affect normal work and the life of people.Once catch an illness, among the bottomless whirlpool of patient will be made to be trapped in frequent recurrence dearly, touchingly not heal, ceaselessly treating.Therefore patient, standing affected area pustule, while erosion, ulcer or causalgia torment, also will bear at any time and may cause the significant stress of the breakdown of a family, causing patient's body and mind all exhausted.Because primary disease recurrence is extremely frequent, each recurrence all can bring patient head-to-toe malaise symptoms.So it is not only the misery on health, its psychological great pain, often changes regular complex state and the Mental Health of many people, causes many mental sickness and mental illness, even suicidal tendency.More unfortunately it can cause social problem, cause marriage and family to be broken to disintegrate, direct physical and mental health of hitting its children, women's psychosoma bears great pain, wound and pressure, causes Abortion and sterility sterile, and particularly of the right age Unmarried is felt oneself inferior self-closing, develop enmity and discontented mood, cause social unstability factor, bring society and the many problems of country, directly affect output and the efficiency of gross national product.The part that this patient forms as society, their survival condition and the whether healthy harmony being directly connected to society.
Herpes zoster is acute herpes sample dermatosis more common clinically, caused by varicella zoster virus.This virus is by respiratory tract infection intrusive body, hides in the neurocyte of dorsal root ganglia or other site of pathological change.This virus is not fallen ill at ordinary times, and when immunity of organisms declines (such as: wound, tired, flu, cancer, disease of immune system etc.), the virus of hiding will amount reproduction and make neuroganglion inflammation, necrosis, causes patient very to itch pain.Virus passes under nervous pathway simultaneously, causes segmental herpes to this innerv region, and clinical be that several bunches of collection herpes groups are arranged in band shape more, and along peripheral nerve distribution, normal is Unilateral, is generally no more than body surface median line, how in irregular zonal distribution.Be common in breast abdomen, back, face, buttocks and legs, crotch.Local skin has burning sensation, with neuralgia.At the beginning of morbidity, main manifestations is that whole body is tired unable, inappetence, and feveret, very itches, and very fast site of pathological change feels scorching hot and jumping property pain.If occur in chest or waist, often by mistaken diagnosis.Occurring in thorax abdomen mistaken diagnosis is heart disease, gastropathy, occurs in waist and is misdiagnosed as gallbladder, kidney calculi symptom etc.Primary disease is equivalent to " herpes zoster ", " herpes zoster ", " herpes zoster ", " fire band is red ", " herpes zoster around the waist ", " herpes zoster ", " flying herpes zoster " etc. of the traditional Chinese medical science, is commonly called as " skirt-roof dragon ", all can falls ill throughout the year.
Herpes zoster sickness rate be crowd 1.4 ‰-4.8 ‰ between, race difference is little, and middle old man is in the majority.According to related data report, about primary disease has accounted for the twenty percent of Dermatology Outpatient Department.Patient is in the past mostly more than 40 years old middle age, and over the past two years, patient age had been reduced to more than 20 year old.The patient of 20% is about had to leave over neuralgia.Many because lacking exercise for a long time, take exercise, stay up late, tired, anger such as to be got angry at the direct stimulation, hypoimmunity (leukemia, lymphatic cancer, acquired immune deficiency syndrome (AIDS), systemic lupus erythematosus (sle) etc.), partial trauma, acute and chronic infectious disease (flu, infectious hepatitis, tuberculosis etc.), nervous system disease (epidemic cerebrospinal meningitis, myelitis, epilepsy, tuberculous meningitis etc., sciatica), hands art, chemicals or medicine and poisoning etc., malignant tumor, weakness waits initiation after being ill.Everyone has the incidence rate of 15 ~ 20 percent in life! Within more than 50 years old, old people is the main population of post-herpetic neuralgia, accounts for about 75% of the number of getting involved; The elderly's sickness rate in 60-80 year is about 50%.Primary disease all has generation throughout the year, and season in spring and autumn, adult are multiple, and the age, larger sickness rate was higher, distinguished without obvious sex.Middle old man's commonly encountered diseases, frequently-occurring disease, very harmful, and also sickness rate presents ascendant trend year by year.
" the cicatrical herpes zoster of gangrenous type ", " disguised herpes zoster ", " general herpes zoster " wherein runs helter-skelter along neural gland in depths because of virus, and the blister of cluster is there is at whole body, companion hyperpyrexia person, become one group of herpes painful, the most serious in primary disease, the oncoming force is very fierce and tough, and pain is more acute, continues to bring out new rash bleb in morbidity, as poisonous snake climbs and stings, make patient apprehension.As occurred in Head And Face with hyperpyrexia person, malpractice many complicated with brains myelitis and post herpetic neuralgia.Especially post-herpetic neuralgia, the local paroxysmal brought to patient or the fire of persistence burns, acupuncture, jumping are jumped, tear, lancinate, shock by electricity, the violent insufferable pain of sample is tightened in rope binding, spiritual quality and the life quality of patient are had a strong impact on, what patient often had that to live is no better than to die indignantly resents, and brings serious financial burden and stress to patient and family.This disease is a pain difficult problem for medical circle, is the healthy potential killer of middle-aged and elderly people.Invade corresponding cranial nerve if any virus can affect one's power of vision, cause facial paralysis and dysacousis.In addition to pain, also can bring out heart disease, cerebral hemorrhage, even cause death.Patient is often because seeking medical advice without door, the long-term slight illness that is subject to torments and suffers untold misery, and occurs depressive symptom, mood disorders, sleep disorder, all do not believe any treatment, ability to work and doings are close to forfeiture, and quality of life is difficult to ensure, to prospect, even life is lost the confidence, often have the thought of committing suicide, household also for this reason worry get involved, its harm exceeds the imagination of ordinary person.
In sum, no matter be genital herpes or herpes zoster, the disease of the refractory of Dou Shi world today MA is the important topic of international related medical scientific research organization long felt, research always.
Before making the present invention, kill the specific medicament of herpes simplex virus and varicella zoster virus because world medicine lacks, among the bottomless whirlpool of make primary disease crowd be trapped in frequent recurrence dearly, touchingly not heal, ceaselessly treating.Therefore patient, while standing ailing torment, also will bear at any time and may cause the significant stress of the breakdown of a family.Its psychological great pain, often changes regular complex state and the Mental Health of many people, causes many mental sickness and mental illness, even suicidal tendency.More unfortunately it can cause social problem, cause marriage and family to be broken to disintegrate, direct physical and mental health of hitting its children, women's psychosoma bears great pain, wound and pressure, causes Abortion and sterility sterile, and particularly of the right age Unmarried is felt oneself inferior self-closing, develop enmity and discontented mood, cause social unstability factor, bring society and the many problems of country, directly affect output and the efficiency of gross national product.The part that this patient forms as society, their existence and health status are directly connected to the harmony of society.This problem does not solve, the great outburst that it will be a long-range social disease, the great outburst of a social problem, the great outburst of a harmonious national stability factor of impact.
Summary of the invention
For background technology with regard to herpes simplex virus and the varicella zoster virus problem without specific drug, the object of the invention is to: a kind of medicine can killing herpes simplex virus and varicella zoster virus is provided, the prevention effect of getting instant result can be produced, meet patient, medical circle, the long-expected common aspiration of human society.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
There is provided a kind of medicine can killing herpes simplex virus and varicella zoster virus, by weight, it is at least that raw material is prepared from by 10-100 part ethanol and 0.1-1 part Mylabris.
In preferred embodiments of the present invention, described medicine by weight, is preferably that raw material is prepared from by the ethanol of 50 ~ 100 parts and the Mylabris of 0.1 ~ 1 part.
In the further preferred a kind of scheme of the present invention, described medicine by weight, is that raw material is prepared from by 100 parts of ethanol and 0.1 portion of Mylabris.
In the further preferred another kind of scheme of the present invention, described medicine by weight, is that raw material is prepared from by 100 parts of ethanol and 0.5 portion of Mylabris.
In further another scheme preferred of the present invention, described medicine by weight, is that raw material is prepared from by 100 parts of ethanol and 1 portion of Mylabris.
In further another scheme preferred of the present invention, described medicine by weight, is that raw material is prepared from by 50 parts of ethanol and 1 portion of Mylabris.
The mass concentration of the ethanol described in the present invention is 10 ~ 95%, and preferred mass concentration is 60% ~ 80%.
Medicine of the present invention not only can take orally but also can external, therefore can be various dosage form of the prior art, such as, can make liquid dosage form or solid dosage forms.
Described liquid dosage form is preferably sterilized tincture, injection stock solution or oral liquid; The preferred powder of described solid dosage forms, tablet, granule, drop pill or capsule.
Medicine of the present invention is with ethanol and Mylabris for prepared by primary raw material, and wherein, ethanol belongs in the classification of Pharmacopoeia of People's Republic of China " Cidex-7, solvent ".Under room temperature, ethanol is the colourless inflammable volatile easy moisture absorption and has the liquid of peat-reek, can dissolve many inorganic matters, can dissolve many Organic substances again; As reaction dissolvent, the Organic substance that participation is reacted and inorganic matter all can dissolve, enlarge active surface, accelerate reaction rate, improve reaction limit.Main active in Mylabris is cantharidin, usually containing cantharidin 1 ~ 1.5%; Mylabris nature and flavor are pungent, hot, very toxic; Return liver, stomach, kidney channel; There is removing blood stasis, eliminating stagnation disappears function that is lame, counteracting toxic substances phagedenoma; Zhu Zhi mass in the abdomen, amenorrhea, stubborn dermatitis, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil.
In the present invention, because the active component cantharidin of Mylabris is very easily dissolved in ethanol, therefore medicine of the present invention can use ethanol to be prepared according to different purposes, different target formulation neatly.Such as, with extracting solution is dry, pulverizing after the conventional soak extraction of the ethanol of described ratio after Mylabris directly can being pulverized, tablet, granule, drop pill or capsule is prepared into further; Also can alcohol water law be adopted to make oral liquid or injection without pulverizing Mylabris; Can also directly with low-concentration ethanol mix with Mylabris soaks after direct to take orally or outward for affected area.
Allow it dissolve medicinal ingredient in Mylabris by the object of ethanol in the present invention, result makes to make it containing a certain amount of cantharidin in product to become the medicament playing specific aim effect for herpes simplex virus and varicella zoster virus, directly solidify the protein of herpes simplex virus and varicella zoster virus, cause it dead.Medicine exterior-applied formulation of the present invention can reach kill herpes simplex virus and varicella zoster virus effect with getting instant result.Dosage form for oral administration also can realize the effect killing herpes simplex virus, varicella zoster virus.
Effect of the present invention is proved below with clinical efficacy contrast statistical report:
1. herpes simplex infections morbidity diagnostic criteria:
1-1 range estimation (prestige, inquiring); The places such as all male's foreskins, glans penis, coronary sulcus, penis, crissum; First there is burn feeling at the places such as female vulva, large nympha, clitoris, vagina, crissum, then there is erythema, then on the basis of erythema, there is multigroup red papules, and feel pruritus due to heat, soon little water kitchen is namely become, after a few days, vesicle becomes purulence, and can form gruel after broken, Most patients has bilateral inguinal lymphadenectasis.
1-2 biochemical investigation: typical clinical symptom patient Virus culture: HSV positive.
2. herpes zoster virus infection morbidity diagnostic criteria:
2-1 range estimation (hope, inquiring): the slightly General Symptoms such as weak, low grade fever, poor appetite can be had before rash, onset has pain suddenly or first, infringement is for there is the large phlysis of gregariousness Semen phaseoli radiati in imflammatory erythema, between have and manifest pimple, bulla or blood blister, the conscious burning sensation of illing skin or neuralgia, that touches has obvious Hyperalgesia, and predilection site is followed successively by intercostal nerves, cervical nerves, nervi trigeminus and waist sacral nerves domination region.There is flushing speckle in affected area Chang Shouxian, occurs the herpes zoster pimple of foxtail millet grain to Semen Glycines size very soon, tufted distribution and not merging, and then become rapidly vesicle, tonic vesicle wall is shinny, limpid vesicle fluid, and periphery is around with blush, and between each bunch of vesicle group, skin is normal; Skin lesion is zonation along a certain peripheral nerve, mostly occurs in the side of health, is generally no more than median line.
2-2 cytolgical examination: isolated viral or detect VZV, HSV antigen or the DNA person of being positive from vesicle liquid.
3. using method and consumption:
3-1 external method and consumption:
3-1-1 is according to severity extent, the lighter uses the flowing product of " embodiment 1-4 " in the present invention, directly embrocate in affected area after soaking into goods of the present invention with the cotton balls of sanitary cotton swab one, each moisturizing more than 1 minute, so repeatedly, or 5-10 minute once, or 10-20 minute once, half an hour to one hour or two little up to a few hours once.
The 3-1-2 person of being in a bad way: look lesion area size, is torn into the cotton block of thickness approximate equality, is laid in focus by health absorbent cotton, then goods of the present invention are sprayed onto absorbent cotton to drench as degree; After absorbent cotton dry half an hour, as above method Reusability, to all naturally coming off after focus incrustation.
3-2 takes method and consumption orally:
As required by " embodiment 5 ", patient can by every day 2-3 time, and each 0.001 gram of-0.03 gram quantity boiled water is taken in meal.
4, treatment requires:
No matter 4-1, for ease of observation of curative effect, is herpes simplex infections patient or herpes zoster virus infection person, must stop using immediately during treatment all Therapeutic Method except the present invention and medicine.
4-2, from taking goods of the present invention, fullly does a biochemical investigation after 30 days, to help to understand therapeutic effect.
5. the course for the treatment of:
Because the present invention " embodiment 1-5 " all belongs to safe dose, without obvious toxic-side effects, therefore and without the need to designing the course for the treatment of.
6. criterion of therapeutical effect:
6-1 external criterion of therapeutical effect:
6-1-1 null criterion: when having no simple genital herpes focus in after external of the present invention uses by " using method and consumption " 24 hours, herpes zoster focus obviously incrustation person is null criterion.
The effective standard of 6-1-2: when in after external of the present invention uses by " using method and consumption " 24 hours, simple genital herpes focus, herpes zoster focus obviously incrustation person is effective standard.
The effective standard of 6-1-3: when in after external of the present invention uses by " using method and consumption " 24 hours, simple genital herpes focus, herpes zoster focus obviously forms a scab or the natural decrustation person of part is effective standard
6-1-4 criterion of cure: when in after external of the present invention uses by " using method and consumption " 108 hours, former simple genital herpes focus, the complete eliminator of herpes zoster focus is criterion of cure.
6-2 takes criterion of therapeutical effect orally:
6-2-1 null criterion: the present invention is taken orally 1 month, through Virus culture: it is null criterion that HSV still shows positive by " embodiment 5 " requirement.
The effective standard of 6-2-2: the present invention is taken orally 1 month, through Virus culture: it is effective standard that HSV shows weak positive by " embodiment 5 " requirement.
6-2-3 criterion of cure: the present invention is taken orally 1 month, through Virus culture: it is criterion of cure that HSV shows negative patient by " embodiment 5 " requirement.
7. patient source and clinical manifestation thereof:
Most humans is from this area Han nationality, and only a few is external employee.The course of disease be 3 days to 17 years not etc.Male is more than female patient.For ease of statistics, the patient between now selecting in February, 1994 to 2013 year December.Wherein, simple genital herpes virus infected patient 604 people, herpes zoster virus infection person 92 people.All patients is outpatient, and clinical manifestation is all outstanding, meets simple genital herpes virus infection morbidity and herpes zoster virus infection morbidity diagnostic criteria person.
8. contrast groups number:
696 people altogether; Age composition situation: PATIENT POPULATION's there was no significant difference that mean age, sex and above-mentioned participation are tested.
9. divide into groups:
9-1 simple genital herpes virus infection morbidity person 604 people is first group;
9-2 herpes zoster virus infection sends out patient 92 people, is second group.
10. point group profile:
In 10-1 simple genital herpes virus infection morbidity person 604, there are 571 people (accounting for 94.54%) for the hospitalier that repeatedly comes after recurrent exerbation for many years; All the other 33 people (accounting for 5.46%) are the hospitalier that just falls ill.
10-2 herpes zoster virus infection sends out patient 92 people, is all neopathy people.
The simple genital herpes virus infection and recurrence person of 571 recurrent exerbation for many years, before the treatment accepting medicine of the present invention, respectively by all types medical institutions with among the peoplely proved without therapeutic effect constantly increasing the weight of repeatedly with various therapy for treating, the present inventor that just comes out of admiration for a famous person locates medical products therapies of the present invention of using instead; All the other 33 onset patients, be 571 after curing for many years non-recidivist introduce or in person bring and seek medical advice, all belong to its relatives and friends.And 92 herpes zoster virus infection send out the poor effect that patient all knows other places treatment primary disease perfectly well, probably leave post herpetic neuralgia, just come because of respect for the fame medical.Therefore these 696 cases itself are treatment group and contrast groups, therefore and without the need to separately establishing contrast groups.For convenience of for the purpose of comparative observation, simple genital herpes virus infection morbidity person, herpes zoster virus infection are sent out patient in " clinicaling curative effect contrast observation's statistics " of lower item and merge into one group.
11. clinicaling curative effect contrast observation's statistics:
1st group: 696 routine patients must observe treatment by external goods of the present invention, and concrete therapy is implemented by " using method and consumption 3-1-2 ".Treat after 24 hours and observe, after having the natural decrustation of 171 routine patient (accounting for 24.57%), reach clinical cure standard; There are 93 people (accounting for 13.36%) just in decrustation; All the other 432 people (accounting for 62%) are all obviously formed a scab; Continue after treating 48 hours (accumulative 72 hours) by " using method and consumption 3-1-2 ", all patients have reached nature decrustation clinical cure standard all.
In 2nd group: 604 example simple genital herpes virus infection morbidity person, there are 22 routine patients while external the present invention is by " using method and consumption 3-1-2 ", successively propose respectively voluntarily to take " embodiment 5 " one month.Through row Virus culture after one month: its HSV is all shown as feminine gender, reach short distance specimen radical cure standard.
12. clinical efficacy contrast conclusions:
12-1, according to upper known: be no matter 604 example simple genital herpes virus Infective patients, or 92 routine varicella zoster viruss cause a disease patient, in use pharmacotherapy of the present invention 72 hours, all can reach clinical cure standard.Wherein have that 22 simple genital herpes disease poison Infective persons reach short distance mark, origin takes stopgap measures standard.The present invention is fact proved than more rich clinical practice: no matter be simple genital herpes virus Infective, or herpes zoster virus infection causes a disease, and all can be cured by the short-term of the present invention in 72 hours.Accordingly, the short distance that can not shake of the present invention is eradicated art and is obtained establishment and consolidation.
12-2, the present invention brings into use so far from February, 1994, finds no any example once healing person's recurrence of the present invention, untoward reaction and toxic and side effects and post herpetic neuralgia.Only 47 routine patients are with in the present invention's treatment, have foaming behavior in affected area, but after syringe needle or toothpick are needled and drained its pus, and focus nature of forming a scab fast comes off and to remain without any cicatrix.Sum up this phenomenon, real have different sensitivity for different individual body constitution to medicine of the present invention, but not toxic and side effects.
12-3, inventor some simple genital herpes virus Infective persons of Stochastic choice and herpes zoster virus infection in outpatients cause patient, make the goods such as powder, tablet, granule, capsule, oral liquid of they external the present invention " embodiment 1-4 ", adopt identical Diagnosis and Treat method and criterion of therapeutical effect above, found that there is the short distance curative effect identical with other.
In sum, medicine of the present invention all has significant prevention effect for herpes simplex virus and varicella zoster virus, in clinical long-term and short term therapy, all obtain unexpected effect, do not find the untoward reaction to sufferer, toxic and side effects and post herpetic neuralgia simultaneously.
Detailed description of the invention
Explain the present invention further by way of example below.
Embodiment 1:
0.1Kg Mylabris raw material is direct or pulverizing is immersed in the ethanol of 65% of 100Kg for after fine powder as required, removes the external-use tincture that Mylabris residue can obtain medicine of the present invention when being Sandy to this mixed liquor.
Embodiment 2:
0.5Kg Mylabris raw material is direct or pulverizing is immersed in the ethanol of 70% of 100Kg for after fine powder as required, removes the external-use tincture that Mylabris residue can obtain medicine of the present invention when being dark brown to this mixed liquor.
Embodiment 3
As required by 1Kg Mylabris raw material directly or pulverize and be immersed in the ethanol of 75% of 100Kg for after fine powder, to this mixed liquor be dark brown or light brown time remove the external-use tincture that Mylabris residue can obtain medicine of the present invention.
Embodiment 4
As required by 2Kg Mylabris raw material directly or pulverize as after fine powder, be immersed in the ethanol of 60% of 100Kg, to this mixed liquor be brown or brownish red time remove the external-use tincture that Mylabris residue can obtain medicine of the present invention.
Embodiment 5
As required the solution obtained in " embodiment 1-4 " is removed ethanol and moisture, the powder being rich in cantharidin is obtained through general spray drying procedures process, and then the adjuvant adding necessity is further prepared into tablet, granule, drop pill, capsule or oral liquid, patient can by every day 2-3 time, and the amount boiled water being rich in the powder of cantharidin described in each 0.001 gram-0.03 gram is taken in meal.
Claims (10)
1. can kill a medicine for herpes simplex virus and varicella zoster virus, it is characterized in that: by weight, it is at least that raw material is prepared from by 10-100 part ethanol and 0.1-1 part Mylabris.
2. medicine according to claim 1, is characterized in that: by weight, and it is that raw material is prepared from by the ethanol of 50 ~ 100 parts and the Mylabris of 0.1 ~ 1 part.
3. medicine according to claim 1, is characterized in that: by weight, and it is that raw material is prepared from by 100 parts of ethanol and 0.1 portion of Mylabris.
4. medicine according to claim 1, is characterized in that: by weight, and it is that raw material is prepared from by 100 parts of ethanol and 0.5 portion of Mylabris.
5. medicine according to claim 1, is characterized in that: by weight, and it is that raw material is prepared from by 100 parts of ethanol and 1 portion of Mylabris.
6. medicine according to claim 1, is characterized in that: by weight, and it is that raw material is prepared from by 50 parts of ethanol and 1 portion of Mylabris.
7. any one medicine described in claim 1-6, is characterized in that: the mass concentration of described ethanol is 10% ~ 95%, preferably 60% ~ 80%.
8. any one medicine described in claim 1-6, is characterized in that: described medicine is liquid dosage form or solid dosage forms.
9. medicine according to claim 8, is characterized in that: described liquid dosage form is tincture, injection stock solution or oral liquid.
10. medicine according to claim 8, is characterized in that: described solid dosage forms is powder, tablet, granule, drop pill or capsule.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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Application publication date: 20160511 |