CN101406514B - External use medicament for treating dermatophytosis - Google Patents
External use medicament for treating dermatophytosis Download PDFInfo
- Publication number
- CN101406514B CN101406514B CN2008100955021A CN200810095502A CN101406514B CN 101406514 B CN101406514 B CN 101406514B CN 2008100955021 A CN2008100955021 A CN 2008100955021A CN 200810095502 A CN200810095502 A CN 200810095502A CN 101406514 B CN101406514 B CN 101406514B
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- CN
- China
- Prior art keywords
- medicine
- treatment
- oil
- external use
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 62
- 206010012504 Dermatophytosis Diseases 0.000 title 1
- 241001460074 Microsporum distortum Species 0.000 title 1
- 208000002474 Tinea Diseases 0.000 title 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 32
- 229930003427 Vitamin E Natural products 0.000 claims description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 16
- 229940046009 vitamin E Drugs 0.000 claims description 16
- 235000019165 vitamin E Nutrition 0.000 claims description 16
- 239000011709 vitamin E Substances 0.000 claims description 16
- 239000002674 ointment Substances 0.000 claims description 5
- 201000004647 tinea pedis Diseases 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 4
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 2
- SODWJACROGQSMM-UHFFFAOYSA-N 5,6,7,8-tetrahydronaphthalen-1-amine Chemical compound C1CCCC2=C1C=CC=C2N SODWJACROGQSMM-UHFFFAOYSA-N 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 229960003645 econazole nitrate Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 229940126673 western medicines Drugs 0.000 abstract 1
- 210000002683 foot Anatomy 0.000 description 10
- 239000000203 mixture Substances 0.000 description 7
- 210000003491 skin Anatomy 0.000 description 7
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000001741 anti-phlogistic effect Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 3
- 241000233866 Fungi Species 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an externally applied medicine for treating Hongkong foot, which comprises Western medicines or traditional Chinese medicines with the functions of sterilization and antiphlogosis. The externally applied medicine for treating the Hongkong foot is characterized in that the medicine also comprises oleovitamin E, wherein the content of the oleovitamin E is between 5 and 95 percent. The externally applied medicine for treating the Hongkong foot adopts the oleovitamin E to help to treat Hongkong foot, greatly reduces the relapse probability of Hongkong foot after treatment, and completely heals more patients.
Description
Technical field
The present invention relates to a kind of medicine for external use for the treatment of the foot moss.
Background technology
The foot moss is commonly called as tinea pedis, be a kind of common by fungus-caused dermatosis, present Therapeutic Method generally is to adopt antibiotic or/and adopt the Chinese medicine of band bactericidal antiphlogistic effect, fungus is killed in external, its early treatment's effect is pretty good, but often be difficult to thorough healing, though perhaps treatment back presentation transference cure recurs again after after a while easily.
Summary of the invention
The object of the invention is to disclose a kind of treatment foot moss medicine for external use that can reduce relapse rate.
Medicine for external use of the present invention includes Western medicine or the Chinese medicine of being with the bactericidal antiphlogistic effect, it is characterized in that this medicine also contains vitamin E oil, and wherein the content of vitamin E oil is 5%-95%.
As further improvement, described medicine for external use comprises by A part medicine and B part medicine two parts medicine of independent packaging and forming that wherein the content of vitamin E oil is 5%-45%, is 55%-95% in B part medicine in A part medicine.A part medicine and the independent packaging of B part medicine are sold together and are used.
The present invention adopts vitamin E oil to come auxiliary treatment foot moss, greatly reduces the recurrence probability after the foot moss is treated, and more patient is thoroughly cured.Its treatment mechanism is still very not clear and definite at present, and preliminary analysis mainly contains following some effect: when 1, being coated in the disease place owing to vitamin E oil, E oil produces one deck oil film at skin surface, skin is played isolate and protective effect; 2, the medicine of the treatment foot moss of prior art; though ingredient wherein can play the effect of killing fungus; but simultaneously skin there is certain detrimental effect; make skin be in tender and lovely state; recurred by fungal infection easily; and the vitamin E composition in the medicine of the present invention can be protected and skin nutrition, reduces the infringement to skin, reduces the recurrence probability.3, vitamin E has antioxidation and anti-aging effects, and Skin Cell is had Nutrition, can impel the faster rehabilitation of skin.
In further improving, the present invention adopts medicine for external use and is made up of A part medicine and B part medicine two parts medicine of independent packaging, wherein in A part medicine, the composition of bactericidal antiphlogistic is more and composition vitamin E oil is less, the early stage use that is adapted at treating, its function is that main maintenance is auxilliary with sterilization, in B part medicine, the composition of bactericidal antiphlogistic is less and composition vitamin E oil is more, be adapted at treating the later stage use, its function is that main sterilization is auxilliary with the maintenance, and both are used and can reach beyond thought better effect.
The specific embodiment
1,, adopt Chinese medicine Radix Sophorae Flavescentis, Fructus Cnidii, sulfur, Borneolum Syntheticum and Western medicine antibiotic econazole nitrate to produce the ointment shape medicine D of common common treatment foot moss according to prior art and production technology.
2, get part ointment shape medicine D, in D, add the vitamin E oil of relatively small amount, stir, become medicine A part with 80: 20 mass ratioes.Vitamin E oil can adopt medicinal finished product E oil.
3, get part ointment shape medicine D in addition, in D, add the vitamin E oil of relative volume, stir, become medicine B part with 20: 80 mass ratioes.
4, medicine A part and medicine B part are independently packed into respectively two flexible pipes, the external packing box of again two flexible pipes together being packed into dispatches from the factory.
When 5, using, medicine is applied to the affected part, uses A to divide medicine in early days, the later stage uses B to divide medicine.
Following table is controlled the moss drug ointment for employing market is commonly used and (is not contained vitamin E oil, other compositions are basic identical with the present invention) and adopt medicine of the present invention to compare treatment situation when treating, two groups of patients are the male, age composition is similar substantially, be toe ditch foot moss, the decortication but do not see the flow liquid that breaks, treatment time is since August, wherein group 1 all adopts same medicine in treatment and consolidation phase, group 2 adopts A part medicine of the present invention at treatment stage, and adopts B part medicine of the present invention in the consolidation phase:
| Group | Adopt medicine | The treatment number | Healing number after 1 month | Cure rate | Healing person is continued medication consolidated after 1 month drug withdrawal 3 months, the recurrence number | Relapse rate |
| 1? | Foot moss medicine is controlled in market | 20? | 13? | 65％? | 6? | 46％? |
| 2? | Medicine of the present invention | 20? | 15? | 75％? | 2? | 13％? |
The treatment situation can be observed from table, and group 2 adopts Drug therapy foot moss disease of the present invention, can make therapeutic effect rapider, and obviously reduce the recurrence probability after the drug withdrawal.
Claims (2)
1. medicine for external use for the treatment of tinea pedis, comprise the ointment shape medicine that is used for the treatment of tinea pedis that adopts Chinese medicine Radix Sophorae Flavescentis, Fructus Cnidii, sulfur, Borneolum Syntheticum and the production of Western medicine econazole nitrate, it is characterized in that this medicine also contains vitamin E oil, wherein the content of vitamin E oil is 5%-95%.
2. a kind of medicine for external use for the treatment of tinea pedis according to claim 1, it is characterized in that described medicine for external use, comprise by A part medicine and B part medicine two parts medicine of independent packaging and forming that wherein the content of vitamin E oil is 5%-45%, is 55%-95% in B part medicine in A part medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100955021A CN101406514B (en) | 2007-10-10 | 2008-04-09 | External use medicament for treating dermatophytosis |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710030834.7 | 2007-10-10 | ||
| CN200710030836 | 2007-10-10 | ||
| CN200710030836.6 | 2007-10-10 | ||
| CN200710030834 | 2007-10-10 | ||
| CN2008100955021A CN101406514B (en) | 2007-10-10 | 2008-04-09 | External use medicament for treating dermatophytosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101406514A CN101406514A (en) | 2009-04-15 |
| CN101406514B true CN101406514B (en) | 2011-03-23 |
Family
ID=40569859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100955021A Expired - Fee Related CN101406514B (en) | 2007-10-10 | 2008-04-09 | External use medicament for treating dermatophytosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101406514B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389654A (en) * | 2016-11-17 | 2017-02-15 | 陈耕 | Composition for treating chilblain, beriberi and onychomycosis and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083709A (en) * | 1992-09-11 | 1994-03-16 | 楼基设 | A kind of method for producing medicines for the treatment of skin tinea |
| CN1286109A (en) * | 1999-08-27 | 2001-03-07 | 付代有 | Exterior-applied medicine for treating beriberi |
| CN1319020A (en) * | 1999-06-03 | 2001-10-24 | 约翰逊及约翰逊法国消费者有限公司 | Extracts of feverfew (tanacetum parthenium) against inflammatory disorders |
| CN1433752A (en) * | 2002-01-21 | 2003-08-06 | 权力敏 | Marine biotin foot-cleaning liquid |
| CN1513476A (en) * | 2003-07-22 | 2004-07-21 | 马柏林 | Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method |
-
2008
- 2008-04-09 CN CN2008100955021A patent/CN101406514B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1083709A (en) * | 1992-09-11 | 1994-03-16 | 楼基设 | A kind of method for producing medicines for the treatment of skin tinea |
| CN1319020A (en) * | 1999-06-03 | 2001-10-24 | 约翰逊及约翰逊法国消费者有限公司 | Extracts of feverfew (tanacetum parthenium) against inflammatory disorders |
| CN1286109A (en) * | 1999-08-27 | 2001-03-07 | 付代有 | Exterior-applied medicine for treating beriberi |
| CN1433752A (en) * | 2002-01-21 | 2003-08-06 | 权力敏 | Marine biotin foot-cleaning liquid |
| CN1513476A (en) * | 2003-07-22 | 2004-07-21 | 马柏林 | Skin-care medicine with functions of relieving-itching, fully eliminating-toxins and curing-tinea, and its prepn. method |
Non-Patent Citations (1)
| Title |
|---|
| 张枫等.苦参在皮肤病外治中的应用举隅.《中医外治杂志》.2007,第16卷(第3期),56-57. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101406514A (en) | 2009-04-15 |
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| C53 | Correction of patent for invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Xu Zhiqiang Inventor after: Xu Rouyun Inventor before: Xu Rouyun |
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Owner name: HUBEI JINGGENG BIOLOGICAL ENGINEERING CO., LTD. Free format text: FORMER OWNER: XU ROUYUN Effective date: 20130822 |
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Inventor after: Chen Geng Inventor before: Xu Zhiqiang Inventor before: Xu Rouyun |
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Free format text: CORRECT: ADDRESS; FROM: 515031 SHANTOU, GUANGDONG PROVINCE TO: 438400 HUANGGANG, HUBEI PROVINCE Free format text: CORRECT: INVENTOR; FROM: XU ZHIQIANG XU ROUYUN TO: CHEN GENG |
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Effective date of registration: 20130822 Address after: 438400, No. 153 Yang Fu Road, eight Li Wan, Hong'an County, Hubei Patentee after: HUBEI JINGGENG BIOLOGICAL ENGINEERING CO., LTD. Address before: 515031 Guangdong province Shantou Shanzhang Park Road No. 32, Room 301 Patentee before: Xu Rouyun |
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| CF01 | Termination of patent right due to non-payment of annual fee |