CN109224024A - For preventing and treating the pharmaceutical composition and its application method of fresh-water fishes bacteria mixed infection - Google Patents
For preventing and treating the pharmaceutical composition and its application method of fresh-water fishes bacteria mixed infection Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The invention discloses a kind of for treating the pharmaceutical composition and its application method of fresh-water fishes bacteria mixed infection.Described pharmaceutical composition includes following components: honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi, and preferred weight ratio is 1:2:2:3:1:1:1.It for fresh-water fishes bacteria mixed infection and has the function of good prevention and treatment by the secondary fresh-water fishes bacteria mixed infection illness of other diseases.
Description
Technical field
The present invention relates to aquacultures, in particular to prevent and treat the technical field of fresh-water fishes bacteria mixed infection medication.
Background technique
The bacterial diseases of fishes refer to the fish disease as caused by various pathogenic bacteria, be in aquaculture it is most common be also harm most
Big a kind of disease has the characteristics that distribution is wide, morbidity is anxious, propagation is fast, morbidity and mortality are high, gives countries in the world water every year
It produces aquaculture and causes earthshaking economic loss, therefore be constantly subjected to the concern of domestic and international fish disease research worker.In recent years
Come, water body environment constantly deteriorates, Cultivated water is contaminated, mismanagement etc. due to, fresh-water fishes be easy to infect water in
Various cause of diseases, the frequent occurrence mixing or secondary infection of some bacteriosis, so far the fish principal causative of separated report
Bacterium has reached tens of kinds, serious to restrict fresh water fishery production.
How to effectively prevent fish bacterial disease, be not only related to the sound development of fishery, more with the food of dining table
Safety is closely related.The main means controlled for a long time fish bacteria disease are to use antibacterials, such as quinolones, ammonia
Base glycoside, Tetracyclines etc. Multiple Classes of Antibiotics are all widely used in for a long time in fresh water fishery production.In recent years, with full society
The common concern of can be to medicament residue and antibiotic resistance the problems such as, government have also carried out on a large scale entire fishing medicine market
It rectifies, discloses large quantities of aquatic products forbidden drugs, such as chloramphenicol, furazolidone, malachite green, pentachloro- phenolic acid sodium in succession.?
Under the joint efforts of various aspects, the use of forbidden drug has obtained preferable control.
But in the breeding process of conventional fish, due to bacteriosis generation relatively frequently, occurring area it is also larger,
Fish commodities market price is more low, and especially the long-term circulative accumulation of deteriorating water quality, fish disease, single bacterium infection are few in recent years
See and present more the situation of COMPLEX MIXED infection.Cultivation dealer still often selects some outmoded methods to carry out disease prevention and cure, special
It is not in drugs such as Water quality declines, the serious shoal of fish of mixed infection, or even abuse antibiotic, so that it is anti-to be easy to produce drug
Property and lead to that the prevention and treatment of fish bacterial disease is more and more difficult, also easily takes serious bad shadow to the quality of aquatic products
It rings and the breeding wastewater of discharge generates direct or indirect pollution to natural environment.
In addition, the research of nutritional physiology has shown that, when using chemicals preventing and curing of fish disease, some chemicals are in fish body
It is not degradable and gradually accumulate, human body is reached finally by food chain, is constantly gathered in human body, eventually to human body
Health generates very big harm, brings serious negative effect to the sustainable development of society.Therefore, in fishery cultivating production
In bacterial disease disease control, the antibiotic substitution Prevention Technique for deeply widely carrying out the bacterial diseases of fishes seems extremely necessary.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese medicines for fresh-water fishes bacteria mixed infection with good prevention and treatment function
Compositions and its application method.
Technical scheme is as follows: it is a kind of for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is described
The bulk pharmaceutical chemicals of pharmaceutical composition include following components: honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi.
Pharmaceutical composition can also include other can be used for treating fresh-water fishes bacteria mixed infection known or known drugs,
Or other assistant products, such as described pharmaceutical composition further includes one of antibiotic, electrolysis multidimensional, disinfectant or more
Kind.
Preferably, the bulk pharmaceutical chemicals of described pharmaceutical composition are composed of the following components: honeysuckle, rhizome of cyrtomium, adlay, purslane,
Rheum officinale, calamus, fructus amomi.
Preferably, the honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi each component mass ratio be 1-3:
1-3:1-3:1-3:1-3:1-3:1-3.
It is optimal, honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi mass ratio be 1:2:2:3:1:1:1.
Further, described pharmaceutical composition is one of the medicinal powder, water extract, ethanol extract by each bulk pharmaceutical chemicals
Or two or more combinations is prepared.Bulk pharmaceutical chemicals of the present invention refer to the raw material for producing pharmaceutical composition of the present invention
Drug can be effective ingredient, be also possible to the carrier (such as Chinese medicine) containing effective component, existence form can be solid-state,
Liquid or other forms.In the specific embodiment of the invention, honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi etc.
Chinese medicine can be referred to as bulk pharmaceutical chemicals.
Further, the medicinal powder of the bulk pharmaceutical chemicals referred to the medicinal powder of 80~100 meshes.
Correspondingly, the application method of the pharmaceutical composition for preventing and treating fresh-water fishes bacteria mixed infection: will be described
Pharmaceutical composition is used alone or is used in combination with antibiotic.Pharmaceutical composition of the present invention can be used as spice and be administered orally,
It can be the modes such as feeding area hanging bag medication.Therapeutic effect is still completed by pharmaceutical composition of the invention in the application method,
Antibiotic is mainly used for controlling secondary infection, can be while treatment after the two cooperation, and treatment is shortened in effectively control secondary infection
Period reduces antibiotic and uses, reinforces therapeutic effect.Pharmaceutical composition and antibiotic are good in the primary and secondary infection of control
Good synergistic effect, treats illness more quickly.
Preferably, the dosage of described pharmaceutical composition is that every double centner fish presses 0.5~1 kilogram daily, admixes feed or system
It is fed at particle.In actual use, it can be used within the scope of the application method according to individual weight, disease condition of the shoal of fish etc.
Medicine method choice, as shoal of fish patient's condition rapidly and seriously, if can take orally simultaneously with hanging bag medication, even appropriate increase dose, or adopt
With antibiotic partner treatment；It, can only oral or only hanging bag medication if shoal of fish patient's condition is slight compared with mitigating.
Preferably, be used alone described pharmaceutical composition or with antibiotic associated with during, auxiliary feeding electrolysis it is more
Dimension also promotes shoal of fish rehabilitation.Can also be during described pharmaceutical composition be used alone or is used in conjunction with antibiotic, auxiliary is fed
Eat the disinfection of region breeding water body.
The theoretical thought of pharmaceutical composition of the present invention:
In above-mentioned formula honeysuckle play clearing heat and detoxicating, anti-inflammatory treatment wind, anti-bacteria and anti-virus, enhancing be immunized it is equivalent；Rhizome of cyrtomium heat-clearing
Cool blood, removing toxic substances desinsection, anti-bacteria and anti-virus；Purslane heat clearing and inflammation relieving, it is clearing heat and detoxicating, dissipate blood detumescence, anti-bacteria and anti-virus；Fructus amomi promoting the circulation of qi
In tune, stomach function regulating is amusing；Rheum officinale clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice；Calamus dampness elimination promoting the circulation of qi, wind-dispelling benefit numbness,
Swelling and pain relieving, opsonic immunity function；Fructus amomi has recuperating qi-blood, by change cold-dampness, warming spleen and appetizing, power of antidiarrheal hemostasis etc..Heat-clearing solution
The benefits of poison is to reach anti-bacteria and anti-virus, it is anti-inflammatory it is anti-infective mutually promote with strengthening the body resistance to consolidate the constitution, the comprehensive effect of performance flavour of a drug compatibility.
Meanwhile during freshwater aquiculture, simple specific bacteria infection it is rare and in virus or Water quality decline or
Parasitic infection or bacterium, which are directly attacked, generally also shows as bacteria mixed infection, on the one hand this pharmaceutical composition considers virus infection
And the bad caused bacterium of water body is secondary or mixed infection, another aspect also directly control the mixed infection that bacterium is Etiological,
It eliminates symptom and complements each other with the cause of disease is eliminated.Honeysuckle is monarch drug in a prescription and takes the relatively large of its conventional amount used, fructus amomi and calamus in side
For minister is auxiliary, rhizome of cyrtomium and rheum officinale is assisted with a task, adlay is to make (in view of water body medication, to be immunized to strengthen to strengthen the body resistance to consolidate the constitution and enhance, through reality
After curative effect confirms, this pharmaceutical composition increases the dosage of adlay), play that broad-spectrum antiseptic is anti-inflammatory and the function for righting of detoxifying altogether.
In addition, the present invention has fully considered the particularity of water body medication: aspect there are two the pathogenetic particularity of fish is main,
First is that usually significant presentation group's fulminant occurs for fish disease --- such as fresh water fish bacterial septicemia, grass carp bacillary enteritis, grass
The parasitic diseases such as fish hemorrhage, fin rot and trichodinasis, doctylogyrosis, sporidiosis, these fish diseases all have group and break out
Property, once will to occur hundreds of fish within a few days dead, even " the empty pool " for morbidity.Second is that the fish disease state of an illness it is complicated and
Easy repeatability --- epidemic characteristic, pathological symptom the case where different fish ponds, protective agents are all dramatically different, with domestic animals and fowls etc.
Control method is far from each other, it is difficult to unified fish disease clinical treatment standard is formed, and the obstinate degree of fish disease, generation frequency in recent years
Rate is all enhancing, and recurrence rate is very high, not only same disease repeated and often the more disease of a fish or different diseases this play that
Volt.
Corresponding fish disease medication also has prominent particularity, one is domestic animals and fowls medication substantially can be according to weight or year
Age accurate quantification, and cultured freshwater fish medication is then difficult to prepare dosage according to weight or age；The second is breeding water body medication
Considering outside control efficiency, is not only needing to consider that breeding water body chemical factors influence, on pharmaceutically-active it is also necessary to take into account that institute's medication
Object is scattered the safety after water body to the security quality and water body environment of fish products；The third is domestic animals and fowls medication can be accurate
Infected animal or adjacent same group motion object are handled, adjustment control prece in due course is changed according to patient's condition, and freshwater aquiculture produces
Medication is then that disease is strong then to be lagged obviously with project setting under use, working condition.
Therefore, in fresh-water fish-culture production the chemicals such as, antibiotic hard to work to single disease medication to water body ring
Border hidden danger is prominent, and the natural drug that present invention choosing is soaked in water without affecting the treatment carries out that prescription, to reach broad-spectrum high efficacy anti-safely
The Chinese medicinal formulae for controlling effect just has significant advantage.
The invention has the advantages that embodying a concentrated reflection of following several respects:
(1) pharmaceutical composition of the invention has good therapeutic effect and anti-infectious function, being capable of balance conditioning fish body
The functions such as body surface barrier, respiratory system, digestive system and immune system, control epidemic situation diffusion；Illness fish can effectively be mitigated face and examine
Symptom promotes physiological function balance to improve, and has no toxic side effect.
(2) pharmaceutical composition of the invention has good control efficiency when being used alone, and is without the use of antibiotic,
The antibiotic resistance for effectively preventing occurring by a large amount of use of antibiotic endangers.
(3) pharmaceutical composition of the invention can also be combined with antibiotic, in the case where antibiotic dosage is less, the short time
The interior bacteria mixed infection that can cure the shoal of fish；
(4) pharmaceutical composition of the invention can not only prevent and treat fresh-water fishes bacterium infection itself, can also prevent and treat by other diseases
Caused fresh-water fishes bacteria mixed infection.
Specific embodiment
The present invention is described in further detail by the following examples, but this should not be interpreted as the scope of the present invention
It is only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill knowledge and
The various replacements or change that customary means is made, should be included in the scope of the present invention.
Embodiment 1
Summer, the hemorrhagic disease of grass carp in the provinces and regions fishing ground such as the Sichuan seen and treated patients, Hubei, Fujian, Guangdong and fin rot mixed infection,
Patient's condition is more violent, Epidemic Scope is also wider, and the course of disease is usually shorter, is mostly several days, and the death rate is high, and production loss risk is big.
It is treated using drug of the present invention: extracting honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus and fructus amomi in mass ratio
The prescription component is processed into powder by crude drug, and 80 mesh are sieved after mixing, is fitted into it is spare in clean moisture-proof vial, daily by 100
Kilogram 0.5 kilogram of spice of fish medication is oral and in feeding area hanging bag, is aided with disinfecting, reinforces the measures such as feeding management, average
Symptom mitigates the time as 24-48h, and the shoal of fish gradually shows the mitigation of body surface focal symptom, diminution, diarrhea and digestive function and gradually repairs
Multiple, symptom is searched for food during mitigating and activity gradually restores, and Population Health degree significantly improves；It is medication the 5th day, every with five point sampling
A point calculates average value after sampling 100 tails, is visible by naked eyes lesion with dignity, feeding activity reverts to effectively, and effective percentage reaches
83% or more, adhere to restoring completely using shoal of fish body surface lesion after the natural drug composition 6~10 days and feeding activity, cure
Without any visible healthy difference between the rear former illness shoal of fish and health population.
In above-mentioned area, grass carp fin rot uses the 5th day each sample point of five point sampling of drug medication of different formulations
100 tails are sampled, as follows by 5 days average efficient concrete outcome data of above-mentioned standard calculating, wherein the shoal of fish of prescription 3-5 uses
Quinolones or aminoglycoside or Tetracyclines single variety antibiotic partner treatment 3 days, antibiotic dosage are said by drug
Bright book:
Treatment condition of the different weight than component drug
Embodiment 2
The red skin disease and enteritis mixed infection in the provinces and regions fishing ground such as Sichuan, Hubei, Fujian, Guangdong.Using drug of the present invention into
Row treatment: the crude drug of extracting honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus and fructus amomi in mass ratio adds the prescription component
Work is at powder, and 80 mesh are sieved after mixing, is fitted into it is spare in clean moisture-proof vial, daily by 100 kilograms of fish medications, 1 kilogram of spice
It is oral, it is aided with disinfecting, reinforces the measures such as feeding management, Average symptom mitigates the time as 24-48h, and the shoal of fish gradually shows
Body surface focal symptom mitigates, reduces, diarrhea and digestive function are gradually repaired, and symptom is searched for food during mitigating and activity gradually restores,
Population Health degree significantly improves；Medication the 5th day, with average value is calculated after five point sampling 100 tails of each point sampling, with honorable nothing
Visually visible lesion, feeding activity revert to effectively, and effective percentage is adhered to up to 90% or more using the natural drug composition 5~8
Shoal of fish body surface lesion and feeding activity restore completely after it, without any visible strong between the former illness shoal of fish after healing and health population
Health difference.
In above-mentioned area, grass carp fin rot uses the 5th day each sample point of five point sampling of drug medication of different formulations
100 tails are sampled, it is as follows to calculate 5 days average efficient concrete outcome data by above-mentioned standard:
Treatment condition of the different weight than component drug
| Project | Prescription 1 | Prescription 2 | Prescription 3 | Prescription 4 | Prescription 5 | Prescription 6 |
| Honeysuckle | 1 | 1 | 3 | 3 | 2 | 2 |
| Rhizome of cyrtomium | 2 | 2 | 3 | 3 | 2 | 1 |
| Adlay | 2 | 3 | 2 | 3 | 2 | 1 |
| Purslane | 3 | 3 | 2 | 2 | 2 | 1 |
| Rheum officinale | 1 | 3 | 2 | 1 | 2 | 3 |
| Calamus | 1 | 3 | 1 | 1 | 3 | 3 |
| Fructus amomi | 1 | 1 | 1 | 2 | 2 | 3 |
| Use antibiotic | / | / | / | / | / | / |
| Antibiotic uses number of days | / | / | / | / | / | / |
| 5 days effective percentage | 100% | 90% | 93% | 95% | 96% | 91% |
| Whole healing times | 5 | 7 | 8 | 8 | 6 | 10 |
Embodiment 3
The hemorrhage in the provinces and regions fishing ground such as Sichuan, Hubei, Fujian, Guangdong, fin rot and enteritis disease mixed infection, patient's condition are fierce
Suddenly, Epidemic Scope is also wide, the death rate is high.It is treated using drug of the present invention: extracting honeysuckle, rhizome of cyrtomium, adlay, horse in mass ratio
Bitterroot, rheum officinale, calamus and fructus amomi crude drug, which is processed into powder, 100 mesh are sieved after mixing, are packed into clean anti-
It is spare in damp vial, it is oral by 100 kilograms of fish medications, 1 kilogram of spice daily and in feeding area hanging bag, be aided with disinfecting plus
The measures such as strong feeding management, while the shoal of fish is matched using quinolones or aminoglycoside or Tetracyclines single variety antibiotic
Close treatment 3-5 days；Average symptom mitigates the time as 24-48h, and the shoal of fish gradually shows body surface focal symptom and mitigates, reduces, diarrhea
And digestive function is gradually repaired, symptom is searched for food during mitigating and activity gradually restores, and Population Health degree significantly improves；Medication the 5th
It is visible by naked eyes lesion with average value is calculated after five point sampling 100 tails of each point sampling with dignity, feeding activity restores
To be effective, effective percentage adheres to living using shoal of fish body surface lesion after the natural drug composition 6~10 days and feeding up to 85% or more
It is dynamic to restore completely, without any visible healthy difference between the former illness shoal of fish after healing and health population.
In above-mentioned area, grass carp fin rot uses the 5th day each sample point of five point sampling of drug medication of different formulations
100 tails are sampled, it is as follows to calculate 5 days average efficient concrete outcome data by above-mentioned standard:
Treatment condition of the different weight than component drug
Embodiment 4
After inventor hemorrhage, water degradation or parasitic infection occurs in scale fishing ground, secondary enteritis or gill rot etc. are thin
The illness shoal of fish with various bacteria mixing and secondary infection symptom, is carried out concentration treatment simultaneously by bacterium infection etc..Using as follows
Method is treated: by 1:2:2:3:1:1:1 mass than extracting honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus and fructus amomi
The prescription component is processed into powder by crude drug, after mixing 80~100 mesh be sieved, be fitted into clean moisture-proof vial, by for
100 kilograms of daily 0.5~1 kilogram of spices of medication are oral, while to because being improved with the measures such as anti-parasite medicine or water transfer oxygenation
Water quality, and be aided with disinfecting, reinforce the measures such as feeding management, it is 24-48h that Average symptom, which mitigates the time, and epidemic situation is spread when 72h
Situation is controlled substantially, is adhered to basic using shoal of fish body surface lesion after natural drug composition 6~10 days and feeding activity
Restore；Medication the 5th day, with five point sampling it is each point sampling 100 tails after calculate average value, with dignity be visible by naked eyes lesion,
Feeding activity reverts to effectively, 86% or more effective percentage；Without any visible strong between the former illness shoal of fish after healing and health population
Health difference.
The result of the bacteria mixed infection of different reasons the present embodiment drug therapy
Claims (10)
1. a kind of for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: described pharmaceutical composition
Bulk pharmaceutical chemicals include following components: honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi.
2. according to claim 1 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: institute
Stating pharmaceutical composition further includes one of antibiotic, electrolysis multidimensional, disinfectant or a variety of.
3. according to claim 1 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: institute
The bulk pharmaceutical chemicals for stating pharmaceutical composition are composed of the following components: honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi.
4. according to claim 3 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: institute
State honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi each component mass ratio be 1-3:1-3:1-3:1-3:1-3:
1-3:1-3.
5. according to claim 4 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: institute
State honeysuckle, rhizome of cyrtomium, adlay, purslane, rheum officinale, calamus, fructus amomi mass ratio be 1:2:2:3:1:1:1.
6. according to claim 1 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection described in -5 any one,
Be characterized in that: described pharmaceutical composition be by one or both of medicinal powder, water extract, ethanol extract of each bulk pharmaceutical chemicals with
On combination be prepared.
7. according to claim 6 for preventing and treating the pharmaceutical composition of fresh-water fishes bacteria mixed infection, it is characterised in that: institute
The medicinal powder for stating bulk pharmaceutical chemicals referred to the medicinal powder of 80~100 meshes.
8. being used to prevent and treat answering for the pharmaceutical composition of fresh-water fishes bacteria mixed infection described in -7 any one according to claim 1
With method, it is characterised in that: described pharmaceutical composition is used alone or is used in combination with antibiotic.
9. it is according to claim 8 for preventing and treating the application method of the pharmaceutical composition of fresh-water fishes bacteria mixed infection,
Be characterized in that: the dosage of described pharmaceutical composition is every double centner fish daily by 0.5~1 kilogram, admixes feed or particle is made
It feeds.
10. being used to prevent and treat the pharmaceutical composition of fresh-water fishes bacteria mixed infection according to claim 7-9 any one
Application method, it is characterised in that: be used alone described pharmaceutical composition or with antibiotic associated with during, auxiliary feeding electricity
It solves multidimensional and promotes shoal of fish rehabilitation.
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| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109908281A (en) * | 2019-04-04 | 2019-06-21 | 四川省畜牧科学研究院 | Domestic animal removing toxic substances composition and application thereof |
| CN109908281B (en) * | 2019-04-04 | 2022-03-08 | 四川省畜牧科学研究院 | Livestock detoxification composition and application thereof |
| DE202023100017U1 (en) | 2023-01-03 | 2023-02-17 | Ravi Dhondiraj Barde | Novel drug for the prevention and treatment of bacterial mixed infections in freshwater fish |
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| CN109224024B (en) | 2021-07-30 |
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