KR20070079596A - Composition of funtional cosmestic for subsidiary skin trouble treatment - Google Patents

Abstract

A supplemental functional cosmetic composition for treating skin disease is provided to rapidly mitigate damaged skin and itchness caused by skin diseases such as eczema and atopic dermatitis without toxicity and side effect. The supplemental functional cosmetic composition for treating skin disease is in the form of liquid type which consists of an extract of Carthamus tinctorius, an extract of aloe, silver, sulfur, potassium hydroxide, alum, pine resin, glycerin, and perfume; and ointment or cream type which consists of an emulsifier, aspirin, sulfur, silver, pine resin, gypsum, cellulose, glycerin, pearl powder, zeolite, cholesterol, an extract of Phellodendron amurense, and perfume.

Description

Functional cosmetic composition for the treatment of skin diseases {COMPOSITION OF FUNTIONAL COSMESTIC FOR SUBSIDIARY SKIN TROUBLE TREATMENT.}

The present invention relates to a composition of a kind of skin care therapeutic auxiliary functional cosmetics containing alum, aspirin, silver, sulfur, rosin, potassium hydroxide, glycerin .

Conventionally, many kinds of functional cosmetic compositions for improving massage and various skin diseases have been developed for skin beauty in Korea and abroad.

However, until now to the present state that satisfies some of the functionalities having the function of improving the whitening, wrinkles, and also has some antimicrobial compositions have been developed in one go, but no obvious effect has been provided yet.

In particular, recently, various functional skin external compositions having some side effects and some effects on the skin are commercially available.

Also, the purpose of cosmetics is to protect the skin, prevent disease, and cleanse the product. However, today, different ingredients from the above-mentioned purpose are used indispensable to the cosmetic composition, causing many problems on the skin.

Cosmetics are made of a composition that prevents diseases by using a skin protective material to pursue the beautification.

Skin diseases In particular, the prevalent atopic disease is a decrease in the amount of ceramides in the cortex, and the skin becomes dry due to a weakening of the water retention function of the cortex, resulting in the aging of the cortex and deterioration of the skin barrier function. Stimulators and antigenic proteins invade the cortex, causing stimulation and allergies, resulting in severe pruritus.

In order to control this, bacteria are attracted in the process of artificially stimulating contact with the skin, followed by eczema and keloid phenomena, resulting in keratinization and inflammatory reactions.

Inflammatory reaction is a biological reaction process for restoring damage caused by invasion, which is the change of matrix on cells or tissues of living body, and local blood vessels, various tissue cells of body fluids and immune cells work in this reaction process. do. At this time, more pruritic symptoms occur, and more irritating contact, so the skin is severely damaged.

The cause of atopy is caused by a complex relationship between genetic cause, environmental factor, generation of lipid peroxide caused by free radicals, infection of bacteria, fungus, virus, etc., but there is no clear cause.

In addition, in order to protect and improve the skin infected with various diseases such as atopic dermatitis, clavicle skin disease such as susceptible purpura, various eczema disease skin, psoriasis skin, ringworm disease skin, and fungal infection skin, conventionally ceramide, linol Ingredients such as rain acids, vegetable oils and mineral oils, arbutin, alpha hydrosic acid (AHA), retinol, nonsteroidal propenamic acid, ibuprofen, bezidamin, indomethacin ( indomethacin, back and steroids such as prednisolone, dexamethasone, allantoin, azene, or a mixture of extracts from any or any of several herb species, or liposomes using phospholipids lecithin It is applied to the stratum corneum of the skin to keep moisturizing and to prevent bacterial contamination. It is used mainly cosmetic.

These substances have been shown to have some effect on the improvement of various skin diseases, but only to alleviate the above symptoms, and the effect of immunological improvement is reported (Moyazawa, k and Mikami. T., Japan j. Parmacol. , 38,199, 1985). In addition, there is a problem of chronicizing the expression into the epidermis of the skin as a potential disease, and there is an urgent need to provide an external preparation for skin that can solve the above problems.

There is still a problem in terms of safety and effective aspects such as adverse effects such as inhibition of epidermal growth and side effects, skin irritation and the occurrence of other contact dermatitis, development of bacteria resistance, the elimination of pruritus, or the promotion of pruritus.

Significant symptoms of skin disease are inflammation and pruritus, and inflammation refers to a pathological condition of abscesses formed by external invasion. And the cultivation is not detailed in the cause, but in general it is seen as a cause of drying and stimulation by the metabolites of bacteria.

When an abscess is invaded into a cell and proliferates, the white blood cell recognizes and proliferates the bacteria that have proliferated. In this process, the dead sea of white blood cells accumulates in cell tissues, which are places of bacterial invasion, and destroys bacteria that are invaded. Abscesses are caused by the dissolution of water into invasive tissues.

Treatment of abscesses by inflammation can be promoted through anti-inflammatory action, and anti-inflammatory action is used to inhibit the proliferation of invading bacteria using antibacterial agents or to activate macrophages that feed on foreign matter accumulated in the abscess to digest the foreign material. And it promotes inflammation treatment, such as promoting the function of the macrophage to excrete.

A key inflammatory mediator that induces inflammatory diseases is eicosanoids. They are produced from the precursor arachidonic acid by cyclooxygenase and lipoxygenase.

Inflammatory diseases are known to involve cyclooxygenase-2, an isoform of cyclooxygenase.

The present inventors studied the inhibitors of the cyclooxygenase-2, antimicrobial agents, bactericides, cell regeneration materials, and pruritus inhibitors, rosin, silver, aspirin, sulfur, alum, potassium hydroxide. It is known that the mixtures of these compounds strongly inhibit cyclooxygenase-2, are toxic to the body and outside, have no side effects and resistance, and are excellent in bactericidal, anti-inflammatory, pruritic improvement and cell regeneration. The present invention was completed.

An object of the present invention, in order to revive the needs of improving the above problems

Non-toxic that does not use the existing active substances with the above problems, and adds the ability to quickly alleviate and improve the disease skin without side effects as a therapeutic supplement external agent for improving a wide range of skin diseases. An object of the present invention is to provide a cosmetic composition having a secondary function of treating a skin disease composed of a non-active composition.

The present invention provides a skin disease treatment-supporting functional cosmetic composition mainly composed of rosin, sulfur, alum, silver, aspirin, potassium hydroxide, glycerin, which is a substance having a skin disease improving function, to achieve the above object.

The mixed composition is hereinafter referred to as STO.

The compositions of the present invention are formulated in liquid and ointment or cream form.

The composition of the liquid is provided for the purpose of washing and disinfecting the skin disease area, improving blood circulation of the anti-inflammatory and skin disease areas, alleviating inflammation on damaged skin tissue, and improving pruritus,

Ointments or creams are used to destroy and disinfect the protective film of bacteria that are foreign substances in the wound. It is provided for the purpose of covering and protecting the skin.

Hereinafter, the present invention will be described in detail.

The proportion of the composition of the STO composition is 9% by weight to 0.1 % by weight to 50 % by weight of the total composition , 5% -20% of an electro-colloidal silver solution having a particle size of 2-15 nm, 0.001% -0.1% of aspirin, and 0.001% -0.2% of sulfur. , Rosin 0.01% -0.15%, potassium hydroxide 0.3% -3%, alum 0.5% -3%, glycerin 5% -60% .

The characteristics of the STO is a general purpose cosmetic composition, a general purpose herbal extract, a general seafood extract, a general animal extract, a general mineral or its extract, a general chemical composition, a general amino acid system, a general vitamin system, a general purpose The STO composition may be mixed with any one selected from any one of the fragrances or any two or more mixed materials and any mixture of materials selected from the above materials to form a material having a therapeutic function for skin disease treatment. Has characteristics.

Skin disease improvement functional composition of the present invention STO is composed of a liquid and ointment or cream form

The liquid composition is hereinafter referred to as STO-B, and the ointment or cream composition is hereinafter referred to as STO-S.

STO-B is an alcohol or distilled water, safflower extract, aloe extract, fragrance is added to the STO.

Referring to the STO-B according to the above is as follows.

Liquid STO-B of the functional cosmetics for improving skin diseases of the present invention is composed of alcohol, distilled water, silver, safflower extract, aloe extract, aspirin, sulfur, potassium hydroxide, alum (alum), rosin, glycerin, fragrance .

The composition ratio of the STO-B is 20g-99% brewed alcohol or 99.99% silver purity 0.1ppm-50ppm, silver ion water of particles 2-15nm, or 20g of aloe extract in weight ratio to 1000g of the mixture of alcohol and silver ionized water. -100 g. Safflower extract 1g-10g. Sulfur extract 10g-60g, aspirin (acetylsalicylic acid) 0.01g-1g. Sulfur 0.01 g-2 g. Alum 5g-30%. Rosin 0.1 g-1.5 g. STO-B is formed by mixing 100 g-350 g of glycerin , 3 g-30 g of potassium hydroxide , and 0.001 g-0.1 g of fragrance .

STO-S is a composition is composed of the addition of emulsifiers, aloe extract, cholesterol, gypsum, pearl powder or zeolite, glycerin, fibrin, sulfur white extract to STO.

Accordingly, STO-S is an emulsifier, silver, aloe extract, aspirin, alum. Consists of sulfur, rosin, cholesterol, glycerin, gypsum, fiber, pearl powder or zeolite, sulfur white extract and flavoring .

The composition ratio of STO-S as an ointment or cream is 0.1% to 60% of any one or any of a plurality of mixed emulsifiers of a general-purpose emulsifier comprising stearic acid in a constituent percentage of the total weight. Aloe Extract 5% -15%. Aspirin (acetylsalicylic acid) 0.001% -0.1%. Alum 0.5% -3%, sulfur 0.001% -0.2%, rosin 0.01% -0.15%, cholesterol 3% -5%, glycerin 5% -60%, potassium hydroxide 0.05% -3%, gypsum 0.8-2.5 %, Cellulose 0.02% -0.1%, pearl powder and zeolite 0.5% -5%, yellowish white extract 1.5% -5%, fragrance 0.001% -0.005%, silver concentration of more than 99.99% purity 0.1ppm-50ppm, silver particles 2-15nm Is composed of 5% -20% of silver ionized water .

And oxytetracycline 2% -5% depending on the skin disease. Depending on the composition of the composition containing other herbs, benzoic acid, crofenensin 0.05% -1.5% is added as a preservative to form a composition.

In view of the above, the composition having a skin disease improvement function of the skin disease improvement functional cosmetics of the present invention is aloe extract, silver, safflower extract, sulfur, aspirin, alum, rosin, potassium hydroxide, gypsum, glycerin, fiber, sulfur white extract, pearl It consists of zeolite, distilled water, emulsifiers and fragrances .

Looking at the action of each component in the composition as follows.

Aloe extract : bactericidal action against bacteria and fungi, toxin neutralization, ulcer treatment, dry and oily skin neutralization, moisturizing. Silver : Sterilization, detoxification. Safflower extract : promotes blood circulation, excretion of fish blood. Itching sedation. Sulfur : Pain Relief. Inflammation. Carriage into active material cells. Regeneration of scar tissue by cell regeneration. Promote blood circulation by relieving lysis blood by antioxidant. Detoxification, sterilization. Aspirin : antipyretic analgesic, anti-inflammatory, bactericidal action. Alum : removing impaired cell damage, dehumidifying damaged cells, damaged cell regeneration, antibacterial activity. Rosin : bactericidal, regulating sebum secretion, damaged cell regeneration, anti-inflammatory action. Potassium hydroxide : Impurity washing and sterilization of damaged skin tissue acting as a protective film of bacteria. Gypsum : Damaged skin protective film, antibacterial action. Glycerin : Antiseptic action, Stimulation relaxation of lean solution, Prevention of harmful substance invasion, Wound mucosal surface protection, External stimulation relaxation, Epithelial detachment for lost cell membrane softening. Fibrin : Protective film formation of damaged cells with gypsum, yellow white extract : Antiseptic, Bacterial propagation, Sterilization, Anti-inflammatory. Pearl powder : whitening, moisturizing, skin immune enhancement, skin weak acid retention, cleansing, blood circulation improvement. Zeolite (silicate) : Adsorption of an active substance into a pore to continuously supply an active substance to damaged cell tissues. Distilled water : dissolves silver, breaks down aspirin, mixes substances.

STO-B and STO-S, the composition of the skin disease improvement functional cosmetic composition of the present invention is to completely improve any kind of skin diseases for a number of skin diseases without adding other substances to the composition Although effective, certain compositions can be added and reacted with STO-B or STO-S to make another composition for the purpose of more rapid improvement in disease improvement, as follows. It can be characterized.

That is to say again in detail, as follows.

The composition STO-B and STO-S of any one or any two or more selected from the general-purpose herbal extracts , a mixture of any one or any two or more selected from the general purpose seaweed extracts , selected from the general purpose animal extract Any one or any mixture of two or more plural substances, a general purpose mineral or extracts of minerals, any one or any two or more plural mixtures, any chemistry selected from general purpose chemicals or mixtures of two or more plural substances, general purpose Functionality of the skin disease improvement functional cosmetics of the present invention by mixing any one or any two or more selected from the fragrance , any one or any selected from among the above substances mixed with STO-B, STO-S The composition can be constructed.

The herb refers to a kind containing ingredients beneficial to the skin, including leaves, stems, roots, berries and oils of various vegetation.

Herbal extracts, seaweed extracts, and animal extracts also contain amino acids and vitamins.

The substance selected in the above description is a substance of an ingredient which can have an improvement effect on any specific skin disease, and is added to the STO-B or STO-S and added by the chemical component of the additional substance, or the STO-B or STO-S By substances produced by reacting with means a substance that can increase the effect of improving skin diseases.

The method for producing a skin disease improving functional cosmetic composition of the present invention is as follows.

The manufacturing method of STO-B

(One). Herbal aloe and safflower extract the active ingredient by general alcohol extraction method and general steam extraction method.

(2). Silver ionized water was prepared by dissolving silver having a purity of 99.99% in distilled water using a commercially available silver dissolving agent to produce silver colloidal silver.

(3). Alcohol content 30% or more Alcohol or silver content 0.1ppm-50ppm. Silver ionized water with a particle size of 2 nm-15 nm. Alternatively, the safflower and aloe extracts are mixed and stirred in a mixture of alcohol and silver ionized water to form a mixture liquid of aloe and safflower.

(4). Then, aspirin and rosin are mixed with alcohol and glycerin to dissolve and solution, or aspirin is reacted with distilled water to be decomposed into acetic acid and salicylic acid.

(5). Potassium hydroxide, yellowish white extract and alum (alum) are put in distilled water and dissolved.

(6). Water-soluble sulfur is reacted with distilled water to form liquid sulfur.

(7). Each of the lysates is mixed and stirred in a container to obtain STO-B as a product.

STO-S manufacturing method

First method. First, put the emulsifier into the container and heat the heated object to reach 80 degrees Celsius-100 degrees Celsius, and then, in the heated emulsifier, silver ionized water, glycerin, pearl powder, cholesterol, aspirin, rosin, sulfur white extract, alum, hydroxide Potassium, gypsum, sulfur and fiber are individually mixed and stirred at about 1 to 3 minutes, and placed in a container.

Second method. Emulsifier, cholesterol, and rosin are dissolved in glycerin, heated in a container, and then aspirin, yellow white extract, alum, potassium hydroxide, gypsum, water-soluble sulfur, and fiber are dissolved in silver ionized water and distilled water, and then put in a mixed solution in the heated container. The mixture is stirred with the heated mixture.

Third method. Emulsifiers, cholesterol, and rosin are dissolved in glycerin and heated, and aspirin, potassium hydroxide, alum, and sulfur are dissolved in silver ionized water and distilled water, followed by mixing and stirring with zeolite, gypsum, fiber, and yellowish white extract.

In the above, the heating is performed after 5 minutes -10 minutes of heating of the heated material to 80 degrees Celsius-90 degrees Celsius, and when the heated material reaches the heating target temperature, the temperature of the heated object is 50 degrees Celsius- The heating is stopped while cooling below 60 degrees.

And when the heat is cooled to 50 degrees Celsius-60 degrees Celsius, it is heated again to 80 degrees Celsius-90 degrees Celsius. Repeated heating as described above continues to mix the heating targets completely and the viscosity increases, the heating and stirring is stopped and cooled to obtain STO-S as a product.

And herbal extracts, seaweed extracts, animal extracts, minerals or extracts thereof, chemicals of general purpose in the STO-B and STO-S. The fragrance is added to form a functional composition, and the weight ratio of each substance added is as follows.

To STO-1 and STO-2, 1% -10% or 10% -30% of any one or two or more kinds of mixtures selected from general purpose herb extracts are added.

To STO-1 and STO-2, 1% -10% or 10% -30% of any one selected from the general-purpose seaweed extract or a mixture of two or more multiple substances is added.

To STO-1 and STO-2, 1% -10% or 10% -30% of a mixture of any one or any two or more selected from a general purpose animal extract is added.

To STO-1 and STO-2, 0.1% -3% or 1% -10% of a mixture of any one or any two or more selected from a general mineral or mineral extract is added.

To STO-1 and STO-2, 0.01% -0.1% or 0.1% -1% of any one selected from general-purpose chemicals or a mixture of two or more multiple substances is added.

To STO-1 and STO-2, 0.01% to 0.1% of a mixture of any one or any two or more selected from general purpose perfumes is added.

In addition, the STO of the present invention is added to a general-purpose herbal extract, a general-purpose seaweed extract, a general-purpose animal extract, a general-purpose mineral or an extract thereof, or any one or more mixtures of general-purpose chemicals having an active ingredient for improving skin diseases. The proportion of silver is 0.1ppm-50ppm of silver concentration of 99.99% or more, silver ion water 5% -20% of silver particles 2-15nm , sulfur 0.001% -0.2%, aspirin 0.001% -0.1%, Alum 0.5% -3%, rosin 0.01% -0.15%, potassium hydroxide 0-3% -3% are contained, and a skin disease improvement functional composition is comprised.

Functional cosmetic composition for the treatment of skin diseases of the present invention, as an external preparation for skin, can be used as an adjuvant for treating human skin diseases, and can be used for treating skin diseases in animals.

When explaining the composition of the skin disease treatment auxiliary functional cosmetics of the present invention, a method for producing the composition, and the function of the composition in detail by way of examples.

However, the present invention is not limited by the embodiment.

Example 1.

The configuration of the STO-B and STO-S will be described in more detail as follows.

The composition ratio of STO-B is brewing alcohol having a concentration of 50% -99% by weight or 0.1ppm-15ppm of silver concentration, 5% -20% of silver solution of particles 2nm-15nm, and silver ionized water (distilled water) or a mixture of alcohol and ionized water 1,000 50 g-150 g of aloe extract , suitably 60 g-100 g, more suitably 60 g-80 g. Safflower extract 15g-80g, suitably 25g-50g, more suitably 30g-40g. 100g-60g of white - white extract , suitably 20g-50g, more suitably 30g-40g. Aspirin (acetylsalicylic acid) 0.01 g-1 g. Suitably 0.02 g-0.5 g, more suitably 0.05 g-0.1 g. Sulfur 0.01 g-2 g. Suitably 0.02 g-0.5 g, more suitably 0.05 g-0.1 g. Alum 5g-30g. Suitably 8g-18g, more suitably 12g-15g, rosin 0.1g-1.5g. Suitably 0.4g-1g, more suitably 0.6g-0.8g, glycerin 100g-350g, suitably 130g-250g, more suitably 150g-200g, potassium hydroxide 3g-30g, suitably 5g- 20 g, more suitably 8 g-12 g, constitute STO-B.

The composition composition of STO-S is comprised as follows.

The composition ratio of each substance in the composition is the composition percentage of the total weight by weight.

Emulsifier 0.1% -60%, suitably 0.25% -50%, more morbidly 0.3% -40%. Aspirin (acetylsalicylic acid) 0.001% -0.1%, suitably 0.005-0.05%, more suitably 0.008% -0.01%. Sulfur 0.001% -0.2%, suitably 0.002-0.05%, more suitably 0.003% -0.01%. Aluminous 0.5% -3%. Suitably 0.7% -2%, more preferably 0.8% -1%. Rosin 0.01% -0.15%. Suitably 0.03% -0.12%, more preferably 0.05% -0.1%. Glycerin 10% -60%, suitably 11% -30%, more suitably 12% -18%, potassium hydroxide 0.3% -3%, suitably 0.4% -2%, more suitably 0.6%- 1%, yellowish white extract 1.5% -5%, suitably 2% -4%, more suitably 2.5% -3.5%, gypsum 0.3% -2.5%, suitably 0.5% -2%, more suitably 0.8% -1.5%, fiber 0.02% -0.1%, suitably 0.03% -0.08%, more suitably 0.04% -0.06%, pearl powder or zeolite 0.5% -5%, suitably 0.8% -3% More suitably 1% -2%, cholesterol 2% -5%, suitably 2.5% -4%, more suitably 3% -3.5%. 0.1ppm-50ppm of silver concentration of 99.99% or more of purity, 5% -20% of silver ionized water of 2-15 nm silver particle, suitably 8% -15%, more suitably 10% -12%, fragrance 0.001% -0.008% , 0.002% to 0.006%, and more preferably 0.003% to 0.005%.

Talc powder 2.5% -6.5% may be added to the composition in order to dissipate unnecessary moisture of the damaged area of skin, dry mucus, and dissipate skin heat.

The compositional proportion of the composition differs greatly in the amount of addition in the compositional proportion because the amount of each component is different depending on the skin of the infant and the skin of the child, the skin of the adult and the condition of the skin disease.

That is, a small amount is added to the skin of the infant and the damaged skin, that is, the epidermis, and a small amount is added to the skin of the child. In addition, the skin of an adult needs an intermediate amount and a large amount is added to the epidermal film, ie, the skin that forms the keratin, among the disease types.

The composition of the present invention is not toxic to the skin even if the composition of the composition ratio in the maximum proportion of the composition ratio.

Alcohol is not added to infants and children as it is accompanied by pain.

And sulfur can be added to increase the value of the added amount in the use of dietary sulfur extracted from pine, the amount of water-soluble sulfur used in the skin of infants and young children under the juvenile is added low. In addition, additives such as potassium hydroxide and aspirin, such as sulfur, vary greatly depending on the amount of adult and child, and the type and condition of the disease.

General purpose emulsifiers include cetyl alcohol, water solubilizer, cetos KD, olive oil wax, monta wax, emulsion wax, etc. In the present invention, stearic acid is selected, but any one or two or more of the above emulsifiers may be used in combination with an emulsifier. You may also do it. As a result, the amount of addition is also large.

The amount of the emulsifier described above may be 0.1%, or there may be no usage limit, such as stearic acid.

Example 2.

Mixing with other substances.

The composition of the present invention retains the functionality of inhibiting skin disease causing agents even when added to a mixture of any of the substances.

According to the present embodiment, the composition of the present invention will be described in detail with respect to the composition of the general-purpose herbal extracts, general-purpose seafood extracts, general-purpose animal extracts, general-purpose minerals or extracts thereof, and general-purpose chemicals.

Since the type of herb uses extracts and dried products of herbs, the amount of liquid extract and the amount of dry and pulverized dry matters vary greatly depending on the materials used.

The composition of the composition of the general-purpose herbal extracts, general-purpose seafood extracts, general-purpose minerals and extracts thereof, general-purpose animal extracts and the like in the composition is as follows.

Three hundred vines (eosungcho), zebra pole, honeysuckle, horsetail, chickweed, comfrey, persimmon leaf, rice bran, mulberry, cocoon, eggplant. Rat melon. Tenza. apricot. peach. Dong-ah. Pomegranate. Sidelines. Acacia, Schizandra. Plantain. Bear smell. Poongyoung. Gold. Kwonbaek. Brotherhood. goldthread. Gold. frankincense. Gyeji, Angelica, Machi, Rhubarb, Ginkgo, Garlic, Yulmu, Centella, Green onion, Perennial, Injin, Green tea, Rose of sharon, Tempered chrysanthemum, Hoi cho, Cactus, Juniper, Chrysanthemum, Chestnut, Taraxacum, Ginseng, Willow, Hodo, Plum, Changzai, Doijin Forsythia, Balsam, Red Ginseng, Purslane, Hojang, Genuine, Pancreas, Corvus, Hyunsam, Chichi, Papaver, Rose, Graft Alley, Ringworm, Ash, Banha, Centella asia Herbs such as Tikara, Seaweed, Licorice, Chamomile, Marigold, Rosemary, Peppermint, Lemon Balm, Douglas, Jasmine, Propolis, Allantoin, Tea Tree, Lavender, etc. One or more mixtures of two or more species are added to the STO-B and STO-S by adding 1% -30% to form a composition.

The herb species include trees, flowers, roots, fruits and leaves.

To the STO-B, STO-S is added 1% -30% to any one or any two or more selected from among marine products such as kelp, coral reefs, wakame seaweed, and the like to form a composition.

The earthworm extract, frog extract, lizard extract, snake extract, branch extract, ant reptiles and insects in the STO-B, STO-S, any one or any combination of two or more selected from a variety of extracts, such as placenta 1 It adds% -30%, and comprises a composition.

0.1% -10% of any one or any two or more selected from minerals such as loess, kaolin, clay, mica, silica, elvan, diatomaceous earth, zeolite, talc, or extracts thereof in STO-B and STO-S To make up the composition.

0.01% of any one selected from chemical antimicrobial agents such as organometallic compounds, anilide compounds, quaternary ammonium compounds, phenols, aliphatic esters, and guanidine compounds in the STO-B and STO-S; -1% is added to make up the composition.

To the STO-B, STO-S is added a 0.01% to 0.1% of any one or a mixture of two or more of the vitamin-based or general-purpose amino acids, such as vitamin A, vitamin B, vitamin C, vitamin E of the general purpose to constitute a composition .

A fragrance | flavor is added 0.001% -0.01%, such as general purpose aroma fragrance.

As described above, the composition of the present invention is a herb extract, a seafood extract, an animal extract, a mineral extract, a chemical, an antimicrobial, an amino acid, a vitamin selected from any one selected from any two or more of any Functional composition for improving skin disease by mixing two or more mixtures with sulfur 0.001% -0.2%, aspirin 0.001% -0.1%, alum 0.5% -3%, rosin 0.01% -0.5%, potassium hydroxide 0.3% -3% Configure

Example 3.

The manufacturing method by the following Example is demonstrated in detail.

The manufacturing method of STO-B is as follows.

Safflower 2g, Aloe 20g, 0.1ppm-50ppm silver or alcohol or alcohol with a purity of 99.99% or more, 1,000ml of distilled water mixed with 15% silver ionized water of 2-15nm silver particles, 0.5g water soluble sulfur (pure S), 0.8g rosin Prepare 0.08 g of aspirin, 10 g of alum, 15 g of potassium hydroxide, and 30 g of glycerin.

First, safflower extract and aloe extract are mixed and dissolved in alcohol. The alcohol is an alcohol having an alcohol concentration of 30% or more, and the higher the concentration, the better. Alcohol is ideally brewed alcohol. A safflower extract and an aloe extract are mixed in the same proportion as the above composition to make a mixed solution of aloe and safflower. When extracted by impregnating dry aloe and dry safflower with alcohol, safflower and safflower 1% by weight ratio. Aloe 10%.

Then, rosin is added to alcohol or glycerin to dissolve to obtain a mixed solution of glycerin and rosin, and potassium hydroxide, alum, and aspirin are dissolved in silver ionized water and distilled water to obtain a mixed solution.

The aspirin is dissolved in alcohol to obtain a solution if it is not soluble in water.

Sulfur dissolves water-soluble sulfur in water to obtain an aqueous solution. The addition amount at the time of adding general-purpose dietary sulfur can also add more than the maximum amount of this composition mixing proportion.

Then, the four solutions are mixed to form a mixed solution, and then the mixed solution is put into a stirring vessel, stirred, and sealed in a container to obtain the STO-B product of the present invention.

And to the STO-B a general purpose herbal extract, seaweed extract, animal extract, minerals and their extracts, any one or any two or more mixtures selected from flavors, or any one or any two or more mixtures selected from the above substances Addition may result in a skin disease improving functional composition.

The above products will be described by selecting three types according to the present embodiment.

The aloe extract in 100 alcohol or distilled water by weight ratio is 5% -20% of the weight of said alcohol or silver ionized water, suitably 8% -15% more suitably 9% -11%. Safflower extract is 0.5% -5%, suitably 0.7% -1.8%, more suitably 0.9% -1.5% of the weight of said alcohol or silver ion water. Eochocho extract 0.52% -2%. Suitably 0.8% -1.8%. More suitably 1% -1.5%. Honeysuckle or Hoi second 5-20%, suitably 7-15%, more suitably 10% -12%, licorice 2-10%, suitably 3-7%, more suitably 4 The STO is added to the composition constituted by adding% -5% to form a composition having a skin disease improving function.

In another embodiment, the composition ratio of STO-B is a weight ratio of 50% -99% of brewed alcohol 1 or 100 of distilled water, and the aloe extract is 5% -20%, preferably 8% of the weight of the alcohol or brine. -15% more suitably 9% -11%. Safflower extract is 0.5% -2% by weight, suitably 0.7% -1.8%, more suitably 0.9% -1.5%. Zinnia vinegar or its fruit extract is 1.0% -5%, preferably 1.5% -4%, more suitably 1.6% -3% of the weight of the alcohol or flash water. 0.5% of the Sasa extract dirt which the alcohol or increase running water 2% by weight, suitably from 0.8% -1.8%, more suitably 1% -1,5%, wood vinegar is 0.1% by weight of the alcohol weight or increase leading -4%, suitably 0.5% -3%. More suitably 0.8% -1%. The STO described in the constituents made up is added to obtain a liquid composition.

Example 4.

Another embodiment STO-B composition ratio is a weight ratio to the concentration of 50% -99% of brewing alcohol concentration is 1 or 0.1ppm-50ppm, particles of 2nm-15nm of the composition to the water, alcohol and the aloe extract in water mixture 100 5% -20%, preferably 8% -15%, more suitably 9% -11%, and safflower extract 0.5% -2% of this weight, suitably 0.7% -1.8 %, More suitably 0.9%-1.5%. Three hundred vines, horseshoe, honeysuckle, horsetail, chickweed, comfrey, persimmon leaf, rice bran, log, cocoon, eggplant. Rat melon. Tenza. apricot. peach. Dong-ah. Pomegranate. Sidelines. Acacia, Schizandra. Plantain. Bear smell. Poongyoung. Gold. Kwonbaek. Brotherhood. goldthread. Gold. frankincense. Gyeji, Angelica, Machi, Rhubarb, Ginkgo, Garlic, Yulmu, Centella, Green onion, Perennial, Injin, Green tea, Rose of sharon, Tempered chrysanthemum, Hoi cho, Cactus, Juniper, Chrysanthemum, Chestnut, Taraxacum, Ginseng, Willow, Hodo, Plum, Changzai, Doijin Forsythia, Balsam, Red Ginseng, Purslane, Hojang, Genuine, Pancreas, Corvus, Hyunsam, Chichi, Papaver, Rose, Graft Alley, Ringworm, Ash, Banha, Centella asia Ticara, Seaweed, Licorice, Chamomile, Marigold, Rosemary, Peppermint, Lemon Balm, Douglas, Jasmine, Propolis, Allantoin, Tea Tree, Lavender or any mixture of 2 or more selected 1% -30 STO is added to% to obtain STO-B.

Example 5.

An ointment or cream composition has a weight ratio to the concentration of 0.1ppm-50ppm, is of a particle is 2-15nm water 50ml-100ml, aloe extract 50g-150g, suitably 60g-100g, more suitably 70g-80g, alum 10g- 40g, suitable amount is 12g-35g, more suitable amount is 15g-30g, selected stearic acid 300g-600g among emulsifiers, suitable amount is 400g-550g, more suitable amount is 450g-500g, sulfur 0.01g-2g, suitable amount is 0.03g -1.5g, more suitable amount is 0.04g-1g. Aspirin 0.01g-1g, suitable amount is 0.03g-0.5g, more suitable amount is 0.04g-0,1g. 0.8g-5g rosin , suitable amount is 0.9g-3g, more suitable amount is 0.8g-2g. Cholesterol 30g-80g, suitable amount 40g-70g, more suitable 50g-60g, glycerin 300g-700g, suitably 350g-650g, more suitably 400g-600g potassium hydroxide 10g-40g, suitably 12g-30g, more Suitably 15g-25g, gypsum 8g-30g, suitably 10g-25g, more suitably 15g-20g, cellulose 40g-100g, suitably 50g-80g, more suitably 60g-70g, white ginseng extract 15g -50g, suitably 20g-45g, more suitably 35g-40g, pearl powder and zeolite 5g-50g, fragrance 0.0012g-0.09g.

Aloe extract 15g-20g, alum 15g-30g, stearic acid 300g-500g, sulfur 0.04g-0.06g. Aspirin 0.04 g-0.06 g. Rosin 0.8g-2g. Cholesterol 50g-60g, Glycerine 20g-400g Potassium Hydroxide 15g-25g, Gypsum 15g-25g, Fibrin 60g-70g, Concentration 0.01% -0.5%, Silver Concentration 20ppm, Silver Ion Water 50ml-80ml, Silver White 35g -40g, 15g of pearl powder and zeolite, 0.04g of fragrance extracted from one or more of aroma species. Then prepare some extra water.

Process : Stearic acid selected from emulsifiers is first put into a heating vessel and heated. Glycerin alcohol is dissolved in rosin, aspirin, sulfur and cholesterol. Also, add potassium hydroxide, sulfur pear extract, gypsum, fiber, and pearl powder to distilled water containing silver ionized water, and then stir, mix and heat the mixture of stearic acid and cholesterol, rosin, sulfur and aspirin heated in a heating vessel, and stir by heating. Stir and cool until each component is completely mixed with each other, add aloe extract and fragrance to the coolant, heat to mild temperature, mix and cool to obtain the product.

Alcohol dissolution is 20 ml of alcohol per 1 g of stearic acid. Heating temperature is 80 degrees Celsius-100 degrees Celsius and heating time is 10 minutes -30 minutes.

Another process is the product.

Put glycerin, stearic acid and cholesterol rosin in the container, mix and heat. Then, potassium hydroxide, aspirin, sulfur white, water-soluble sulfur, gypsum, fiber, pearl powder are mixed with silver ionized water, mixed with the heated mixture, stirred, heated, heated, stirred and cooled until completely mixed, and then extracted with aloe extract. The fragrance is added to a closed container to obtain a product.

Production of another method yields the product.

A mixture of stearic acid and cholesterol, yellow white extract, rosin, and glycerin is placed in a container and heated. The mixture of sulfuric acid solution, potassium hydroxide, and aspirin was mixed with silver zeolite and mixed with silver ionized water with pearl powder, gypsum, fiber, aloe extract, and flavoring, and then evenly stirred, then mixed with the heated mixture and stirred evenly. The mixture is heated at low temperature and cooled to obtain a product in a container.

The heating temperature of the mixture in the heating vessel is 50 degrees Celsius-100 degrees Celsius.

The mixture is continuously stirred, but the heating time is heated for at least 30 minutes. After the heating, the titration time of the mixtures was mixed at a temperature of 30 degrees Celsius to 50 degrees Celsius, and then heated and stirred for 10 minutes or more at a temperature of 80 degrees Celsius or less, and an ointment was obtained to grind at least 300 mesh-500 mesh with a grinder. The mixture is heated at 50 degrees Celsius-80 degrees Celsius for 10 minutes or more, heated and cooled to obtain a composition STO-S of a functional cosmetic that improves the skin disease of the present invention. Fill and seal the container.

In order to prevent spoilage of the composition, grapefruit extract or oxytetracycline may be added and mixed in place of sulfur white before heating the mixture. The mixing proportion is equal to the amount of sulfur white added. And also talc can be added. At this time, the addition amount is 30g-60g. You can also add preservatives. The amount added depends on the type of preservative. Therefore, what is necessary is just to mix according to the addition amount of the general purpose preservative.

If distilled water or silver ionized water is added a lot, a dilute solution is obtained. If distilled water or silver ionized water is added, an ointment (cream) is obtained.

Example 6.

A characteristic of the STO-S of the present invention is a general-purpose herb or general-purpose seaweed, which helps to improve skin diseases in the composition prepared according to the embodiment according to the type of disease in which skin damage is progressing due to skin diseases, or General purpose animal extracts, general purpose minerals or extracts thereof, or chemicals, general purpose vitamins, general purpose amino acid systems of any kind selected from any one or any two or more mixtures of any two or more of the above 0.1% -30% is respectively added by weight ratio to the mixture, and the mixture is heated and stirred for 10 minutes or more at a temperature of 80 degrees Celsius or less to obtain a skin disease improvement functional composition.

The addition amount is a large amount of herbs and seafood added to the STO-S, the addition amount of mineral extracts, chemicals, animal extracts is a small amount of the additives and the addition amount is also a variety of additions are not important components in the description of the present invention. The specific addition amount between and maximum is not shown.

Examples of the above kinds of materials are as described in Example 2.

If you explain another example,

In the STO-S of Example 5 10g-20g, suitably 12g-18g, more suitably 13-16g, safflower extract 0.5% -2% by weight, suitably 0.7% -1.8%, More preferably 0.9% -1.5%. Zinnia extract 0.8g-15g, suitably 10g-20g, more suitably 11g-13g, talc 30g-80g, suitably 35g-70g, more suitably 40g-60g and the above-mentioned STO-S Mixed compositions are constructed.

In another example, the composition of STO-S of Example 5 was mixed with 0.05% -2% by weight of selenium-aspadate, amino acids, vitamins B and E, and triclosan, respectively, in a weight ratio of It is composed.

In another example, Yulmu extract, earthworm extract, eoseongcho, gold and silver, Uiseong Forsythia, Balsam, Purslane, Pleurotus eryngii, Red Ginseng, Panther, Camellia japonica, Hyunsam, Gapgoe, Ocher, Germanium, Serenium, Vitamin E, respectively The composition which the said STO-S addition-mixed is comprised to the structure comprised by mixing by 0.05% -5%.

Also, in the following example,

a). For the swelling of skin diseases.

STO-B, STO-S 5 kg apricot seed (passenger), peach seed (doin), bear cherries, pogongyoung, gold and silver, yellow and white, golden extract and any other or any combination of herbs 2.5 g-250g is mixed and diluted to obtain a skin disease treatment aid functional cosmetic composition.

b). Pain Relief, Calm, Anti-inflammatory.

STO-B, STO-S 5kg contains extracts of pogongyoung, three hundred seconds, gold and silver, apricot seed, peach seed, golden, umseong forsythia, balsam, purslane, larvae, panbuche, horsetail, and other analgesic, nourishing, soothing effects 2.5 g-250 g of any one or a plurality of mixtures selected from the herbs contained are mixed and diluted with STO-B and STO-S to obtain a skin disease treatment aid functional cosmetic composition.

c). To improve pruritus.

STO-B, STO-S 5kg 2.5g-250g of any one or any mixture selected from Kwonbaek, three hundred seconds, hyungae, rhubarb extract and other herbs containing potent ingredients STO-B, STO-S The mixture is diluted and stirred in the mixture to obtain a skin cosmetic treatment aid functional cosmetic composition.

d). To animation.

STO-B, STO-S 5kg 2.5g-250g of any or any mixture selected from frankincense, pogongyoung, gyeji extract and other herbs mixed and diluted with STO-B, STO-S and stirred To obtain a functional cosmetic composition for treating skin diseases.

e). To athlete's foot by fungus.

STO-B, STO-S 5kg 2.5g of white powder, Schisandra chinensis, eggplant extract, wormwood extract, sapphire root extract, cedar leaf extract and any other selected from any other herb 2.5g -250 g is mixed and diluted with STO-B and STO-S to obtain a functional cosmetic composition for treating skin diseases.

f). To the dead.

STO-B, STO-S 5kg mixed with 2.5g-250g of any one or any mixture selected from eggplant, rat melon, tanza, Baekbongryeong extract and other herbs, mixed and diluted with STO-B, STO-S It is stirred to obtain a functional cosmetic composition for treating skin diseases.

g). On swelling and eczema.

STO-B, STO-S 5kg 2.5g-250g of any one or any mixture selected from three hundred seconds, perilla, Schizandra chinensis extract and other herbs, mixed with dilute STO-B, STO-S and stirred to skin A disease treatment aid functional cosmetic composition is obtained.

h). Hives, itching.

STO-B, STO-S 5kg, 2.5g-250g of any one or a mixture of wormwood extract, licorice extract, aloe extract, docomari seed and other herbs selected from STO-B, STO-S The mixture is diluted and stirred in the mixture to obtain a skin cosmetic treatment aid functional cosmetic composition.

g). Dry ringworm,

STO-B, STO-S 5kg 2.5g-250g of garlic juice, leek extract, aloe extract and any other selected from a variety of herbs and mixed mixture dilution of STO-B, STO-S and dilution Obtaining a functional cosmetic composition for treating skin diseases.

i). To recover wounds.

STO-B, STO-S 5kg mixed dilution 2.5g-250g of any one or any mixture selected from Centella asiatica extract, aloe extract and other herbs mixed in STO-B, STO-S It is stirred to obtain a functional cosmetic composition for treating skin diseases.

j).

Functional cosmetics effective for the repair of wounds damaged by athlete's foot include, in the STO-B or STO-S, 15 g-20 g of cypress extract added to the composition at a heating temperature of 80 degrees Celsius or less and stirred to obtain an ointment or diluted solution. A functional cosmetic composition for treating skin diseases is obtained.

k).

Cosmetics effective for malignant eczema and malignant atopy, put 15g-20g each of the peach leaf extract, complex seed oil in the STO-B, STO-S and heated and stirred at a temperature of 80 degrees Celsius or less for 10 minutes or more ointment or diluted solution ( Suspension composition).

l).

The cosmetics effective for chronic skin condition are put into the ointment or dilute solution consisting of STO-B, STO-S, white ginseng, three hundred seconds, hyungae, rhubarb, golden mixed extract 15g-20g at least 80 minutes at a temperature of 80 degrees Celsius or less The mixture is heated and stirred to obtain a composition of an ointment or a dilute solution.

m).

For cosmetics that are effective for chronic athlete's foot aggression, mix 15g-30g of ST-B and STO-S with extracts of warm oil and Schisandra chinensis, respectively, and heat them at a temperature below 80 degrees Celsius for at least 10 minutes to treat skin disease in a thin solution. A secondary functional cosmetic composition is obtained.

The black powder means a material made of carbon by burning.

n).

For coarse skin beauty, gamma-oryzanol, arbutin, chamomile extract, ceramide, lecithin, cucumber extract, licorice extract, hyaluronic acid, lettuce extract, marine collagen, beta glucan, allantoin, vitamin derivative, aroma essence, ginseng extract, green tea extract, zeolite Composition STO-B of the present invention in 100% of the mixture. STO-S is mixed to obtain a skin disease treatment aid functional composition.

m).

STO-B. In a material in which a general cosmetic composition is mixed with a mixture of white vertebral body, weight, changja, allies, windproof, mold opening, barberry, jujube, island skin, natural barley, and barley. STO-S is mixed to obtain a skin disease gum support functional composition.

The functionalities of the importance of the STO-B and STO-S will be described in more detail as follows.

The components of safflower flower are p-cymene. limonene. α-phellandrene. γ-terpinene. 4-terpineol. selinene. β-eudesmol.

As a fragrance component, phenylacetaldehyde. 2-phenylethylalcohol. 4-terpineol. β-caryophylline. γ-terpinene. α-phellandrene.

As aldehydes, 3-methylbutanal. 2-methylbutanal. pentanal. hexanal. octanal. nonanal. decanal.

As alcohols, 2-pentanol. heptanol,

As ketones, 3penten-2-one. 2-heptanone. 2,6,6-trimethyl cyclohexanone.

As acids, acetic acid. heptanoic acid. 2-methylbutanoic acid. It is composed of 3-methylbutanoic acid (isobaleric acid) with rancid-cheeseodor. The substances decompose fish blood at the site of the skin disease, and break down fatty acids to facilitate the smooth communication of blood. Harmless and nontoxic.

The ingredients of aloe are steroids. Aloetin. Aloe Ursin. Alomitin. amino acid. Saponin. Antibiotics, wound healing hormones. It has many minerals, and its effect on skin diseases is to neutralize the bactericidal power of bacteria and fungi and toxins in skin diseases. Skin ulcer treatment effect. Neutralizes dry and oily skin and moisturizes the skin. Harmless, harmless and no side effects.

Silver ionized water is a solution obtained by dissolving silver in distilled water by electrolysis of 99.9% silver. It has strong antibacterial, bactericidal and detoxification effects on diseased areas. Silver is harmless and nontoxic. After antibiotics were first discovered in Boston in 1964, Dr. Carls Mayer, president of Washington University School of Medicine in the 1970s, revealed that Colloidal Silver is a natural antibiotic that does not cause bacterial resistance. If the silver product is used in the same way used by the FDA in testing, it can continue to be sold without providing evidence of safety and efficacy, and is used throughout the United States and Europe. Silver has certified the excellent effects and no side effects of killing more than 650 bacteria in the study.

The silver component has the effects of antibacterial, bactericidal function, and skin regeneration of the STO-B, STO-S. Harmless, harmless and no side effects.

Stearic acid (C18H3602) consists of a mixture of solid fatty acids. The acid value is 196-211 and the freezing point is 54.5-69.0. The mixing function of the composition materials and gypsum, fiber, alum, rosin and mixing action to form a protective film on the damaged skin. Harmless and nontoxic. Harmless, harmless and no side effects.

Aspirin (acetylsalicylic acid) is broken down into water to form acetic acid and salicylic acid. It has the effect of antipyretic analgesic on the damaged area of skin disease, and improves the combined solubility, stability and pharmacology with mixed composition materials. In addition, it removes the pathological proliferation of keratinous skin areas and acts as a methyl ester, analgesic and antiseptic action of the skin diseases. And involved in preserving the present mixed composition. The appropriate amount is harmless and harmless, and has no side effects.

The rosin is not soluble in water and dissolved in organic solvents such as ethyl. Resin powder 70% -75%. Terebin oil 18% -22%, rosin acid (60% -65%) is composed of levopimaric acid and neoabietinic acid and is a disinfectant for wounds. It is involved in wound regeneration, stearic acid and mixed wound protection. Harmless, harmless and no side effects.

Alum (alum) is involved in swelling, wound healing, removing skin and other substances, boosting new flesh, dehumidification and oily removal. In the present invention, using alum and half alum and alum. Harmless, harmless and no side effects.

Sulfur works with organic substances to form pentathionic acid (HO-SO2-S3-SO2-OH), which dissolves keratin harmlessly to the human body and acts as a pesticide. Sterilizes and removes the causative bacteria, bacteria, viruses, bacteria and fungi of the spear, lower window, nematode nematodes, scabies and ringworm, and removes skin poisons.

Sulfur has a strong pain relief action, strong substance binding and transporting properties to penetrate the composition of the present invention deep into the cell membrane to exert weakness, strong interlocking action to prevent skin aging, and to quickly regenerate cells It reduces scar tissue of lost skin and has strong antioxidant activity, releasing the dissolved blood of damaged skin and promoting blood circulation.

Sulfur is the eighth vital necessity in the human body and contains about 140 g.

Sulfur is deeply involved in the skin's ability to purify (wrinkle, elasticity), the keratin protein in the epidermal layer prevents the loss of water to maintain moisture. It detoxifies harmful substances deposited on epidermal tissue and maintains skin elasticity by sticking together various amino acids constituting collagenase enzymes directly involved in collagen molecules that contribute to skin elasticity.

Sulfur is a water-soluble solution that is legally formulated to be toxic to sulfur. Water Soluble Dietary Sulfur is harmless, nontoxic and no side effects.

Hwangbaek extract is a Berberine substance extracted from the bark of the bark and has a strong bactericidal power without resistance to bacteria such as antiseptic, gram-positive bacteria, gram-negative bacteria and gonorrhea bacteria.

Harmless, nontoxic, no side effects.

Fibrin is cellulose. It is the cell wall of the plant. The chemical formula is C6H1005, an odorless white matter. It is the largest molecular weight among polysaccharides and its molecular weight ranges from tens of thousands to hundreds of thousands in its natural state. A large number of cellulose molecules form a fiber, the minimum unit of which is called a micelle. The micelles are 0.05 nm in diameter and 0.6 nm in length or more. Improving skin diseases into the skin of the damaged area of the skin penetrates the effective mixture, regenerates the skin tissue, and forms gypsum, alum, stearin and a skin protective film. Harmless, harmless and no side effects.

Gypsum removes impurities from the skin when massaging skin diseases and rapidly coagulates mucus in the area of skin disease, leading to a protective film form to protect damaged skin. Harmless, nontoxic, no side effects.

Cholesterol acts to coagulate impure mucus, such as gypsum, and to involve peripheral blood vessels in which the lost blood is present and to induce blood purification by treating the damaged blood. Harmless, nontoxic, no side effects.

Talc powder discharges unnecessary moisture inside the skin of the skin disease area to the outside to dry mucus such as eczema and lower the heat of the skin. Harmless, nontoxic, no side effects.

Glycerin protects the mucous membranes of diseased areas by inhibiting bacterial propagation, antiseptic action, and lean solution, preventing evaporation of moisture and fragrance of the composition, protecting skin diseased areas, and softening function. Harmless, nontoxic, no side effects.

Potassium hydroxide destroys the protective film of bacteria consisting of secretions of skin diseases, removes impurities by washing, and has a bactericidal function. Appropriate amount harmless and no side effects.

Pearl powder is water soluble and contains abundant minerals and bioactive substances, and it has functions to maintain weak acidity and moisturizing function of skin, enhance skin immunity, promote blood circulation and cell regeneration. Harmless, nontoxic, no side effects.

Zeolite is a porous material that promotes skin physiology by ion exchange, toxin drainage, antibacterial, pathogenic exfoliation, and keeps active substances in contact with the diseased skin. Harmless, nontoxic, no side effects.

STO-B is a composition of the skin disease improvement functional external preparation cosmetic of the present invention as described above. STO-S breaks down the protective film of harmful bacteria and quickly invades the active substance of the composition of the present invention into the subcutaneous tissue and continuously sterilizes, promotes blood circulation, releases toxins of the skin, and maintains the stability of the skin. It enhances the physiological stimulation of skin, protects and regenerates damaged skin quickly, prevents moisturizing and weak acidity, prevents wrinkles and occurrences, neutralizes dry and oily skin, and relieves or eliminates pain and itching. .

According to the composition of the skin disease-improving functional external preparation cosmetic composition of the present invention, according to the experiments of the following examples, it has a feature that can be used as an adjuvant of therapeutic drugs for skin diseases beyond the level of improving the disease of the skin.

Method of using the composition of the skin disease improvement cosmetic composition of the present invention by spraying the liquid on the diseased skin with a spray or the like to massage the active ingredients of the liquid into the skin by lightly tapping, then applying an ointment or cream to the skin to massage the skin After letting the ingredients of the composition soak into the skin. Covers the skin with a certain amount of skin disease to cover the wound to protect the damaged skin.

Example 7.

Experimental Example 1 Cyclooxygenase-2 Inhibitory Effect.

As described above, experiments were conducted to know the effect on the activity of cyclooxygenase-2 in the composition prepared according to the present invention.

After cultivating RAW 264.7 cells by Chi method and adding riboplisaccharide, the amount of prostagradin E ₂ , an arachidonic acid metabolite produced by cyclooxygenase-2 after 24 hours, was determined by ELISA method. Quantified by the Caman company is shown in Table 1 below.

In addition, to measure the inhibitory ability of cyclooxygenase-2 (cyclooxygenase-2) directly after washing for 24 hours after treatment with ribopli saccharite prepared by the achidonic acid (archidonic acid) and Example 3-Example 5 It was measured 30 minutes after the addition of the composition STO-S. The results were repeated three times and are shown in Table 1 below (Biochem Pharmacol. 61. 1195-1203 <2001>).

TABLE 1

Inhibitory Effect of Prostaglandin E ₂ Production in RAW264.7 Cells

As can be seen from Table 1, the composition of the present invention was found to inhibit the production of prostaglandin E ₂ at a concentration of 25 μg / ml without cytotoxicity. As shown in the results of the 30-minute experiment, it was found to directly inhibit cyclooxygenase-2.

Experimental Example 2 Cyclooxygenase-2 Inhibitory Effect

First, 1,100 μM arachidonic acid and 25 μg hemoglobin were added to Tris buffer solution (0.1 M. pH 8.0) to make a substrate, and 10,000 units of cyclooxygenase and STO-S prepared according to Example 3-5. Are added at different concentrations. Cyclooxygenase activity of the enzyme was determined by measuring the initial oxygen consumption (Yellow Spring Intrument Company.Model 53 oxygen monitor) and the results are shown in Table 2 below.

TABLE 2

Inhibitory Effect of Cyclooxygenase-2

As can be seen in Table 2, it was confirmed that the cosmetic composition, which is an external preparation for treating skin diseases of the present invention, has an excellent inhibitory effect on cyclooxygenase.

<Experimental Example 3> The effect of inhibiting bacterial growth of the product produced by the above-mentioned Example of the present invention.

This experiment is to evaluate the composition by recording the separation rate of mold and bacteria in the skin after adapting the composition to the case that is very difficult to treat due to skin diseases. In addition, the present experiment on bacteria and fungi is to determine whether the application of the composition in the actual clinical feasibility.

This experiment targets skin disease symptom convulsions that afflict many people, and especially in the case of constriction with bacterial skin disease, the efficacy of the composition prepared by the present example is evaluated.

1, To determine the bactericidal ability of the skin bacteria in the laboratory and to measure the aberration separated after the application in the actual skin in the future to prove its sterilization ability. Therefore, for such experiments, the isolation and susceptibility test of bacteria through blood medium should be preceded and the bactericidal capacity of the microorganism researcher is verified.

a). Antimicrobial activity against Gram-positive cocci.

Staphylococcus intermediusrbs strain of atopic dermatitis was identified and used in this experiment. This strain is the most commonly isolated strain from pyoderma and is the causative agent of superficial and deep pyoderma. Therefore, to determine the effect of the present composition on staphylococcus aureus, the main cause of infection of skin diseases, using the strain, an experiment is performed as shown in Table 3 below.

1) Use strain: Staphylococcus intermediusrbs isolated from atopic dermatitis skin.

2) Experimental Method: 2 clony of Staphylococcus aureus cultured in blood medium was suspended in 30ml physiological saline and diluted again 1000 times.

Negative control bacteria: 9.99ml saline and 10ul bacterial suspension.

Positive control bacterium: 9.99ml saline solution (cephalexin: final concentration -100mg / ml) and 10ul bacterial suspension. The reaction was carried out as above. The bacterial colonies of each group were measured at intervals of 10 minutes, 30 minutes, and 1 hour after the reaction (plate method).

3) Results: In the treatment of the present invention, as shown in Table 4, the growth of bacteria was suppressed 100% in all of 10 minutes, 30 minutes, and 60 minutes.

TABLE 3

Experiment method

TABLE 4

Comparison of Antimicrobial Activity against Gram-positive Cocci of the Compositions among Experimental Groups

As shown in Table 4, the growth of Staphylococcus aureus was confirmed in the negative control group because it did not contain antimicrobial agents. In the group using cephalexin as a positive control group, the growth of bacteria was observed in 10 minutes, 30 minutes, and 60 minutes. 100% inhibition. Accordingly, the present composition STO will be recognized that the antimicrobial activity against Gram-positive cocci, especially staphylococci.

b). Antimicrobial activity against Gram-negative bacilli.

Escherichia coli (E. coli) strain isolated from urine of dogs infected with urinary infection was isolated and used for this experiment.

One). Use strain: Escherichia coli (E. coli) as E. coli.

2). Experimental Method: Two colonies of colonies of E. coli cultured in blood medium were suspended in 30 ml saline solution and diluted 1,000 times.

Negative control bacteria: 9.99ml saline and 10ul bacterial suspension.

Positive control: 9.99 ml of saline (sephalexin: final concentration -100 mg / ml) and 10 ul of bacterial suspension.

Treatment group: STO 9.99ml and 10ul bacterial suspension.

The reaction was carried out as described above, and bacterial colonies of each group were measured at intervals of 15 minutes, 30 minutes, and 60 minutes (plate method).

TABLE 5

Experiment method

TABLE 6

Results of antimicrobial activity test against Gram-negative cocci of STO between each experimental group

As shown in Table 6, the growth of Escherichia coli was confirmed in the negative control group because it did not contain the antimicrobial agent. In the group using cephalexin as the positive control group, the growth of bacteria was increased in all 10, 30, and 60 minutes. % Was suppressed. Accordingly, the present composition STO will be recognized that the antimicrobial activity against Gram-positive cocci, particularly E. coli. The antibacterial activity of E. coli is recognized as a cleaning agent for skin damage.

Experimental Example 4 Anti-inflammatory Effect Test

In order to determine the anti-inflammatory effect of the present invention, STO, A. Crummey, GP Harper, EA Boyle and FR Mangan. Inhibition of arachidonic acid-induced ear edema as a model for assessing topical anti-inflammatory compound.Agents and Actions 1987: 20: 69-76.

Each of 35 hairless mice was cleaned with ethanol prior to sample application, and each ear was measured with a micrometer, and then treated with 0.5% and 1.0% STO and indomethacin. ) The experiment was divided into a comparison group treated with 1.0% and a control group treated with only arachidonic acid, and the average value of the ear thickness of the mouse was measured. The sample group treated with STO and the comparative group treated with indomethacin were continuously coated with 20 μl of the sample and 20 μl of ethanol to the control group once daily for 4 hours. One hour after the last application, ethanol was applied to the left and arachidonic acid to the right ear, and 2 mg / ear was applied to the right ear. After 1 hour of application, the edema of the ear was repeated three times for each ear using a micrometer. Measured. The left ear of the treated group was used as a control to determine the degree of inflammation caused by the sample itself. Anti-inflammatory effect was determined in the degree of edema inhibition based on the control group treated with arachidonic acid only, and the results are shown in Table 7.

TABLE 7

A: average thickness change of control ear

(Arachidonic acid-treated ear thickness-untreated ear thickness)

B: Thickness of sample coated group ears-thickness of untreated ears

(Thickness of sampled ears-thickness of untreated ears)

As shown in Table 7, the 1.0% STO sample of the present invention showed a high inhibitory rate of 59.27%. These figures were shown to have a better anti-inflammatory effect than Indomethacin, which is a very good anti-inflammatory substance as a pharmaceutical ingredient. In addition, when the significant difference was verified by the increase rate of edema, STO showed an effect having a better difference with arachidonic acid.

Experimental Example 5 Cytotoxicity Test 1.

Method for MTT test by culturing V79-4 cells (Chinese hamster, continuous cell line of lung tissue fibroblasts) against STO to verify primary stability as a raw material used in cosmetics [Mossman T. (1983) . Rapid colorimetric assay for cellular growth & survinal: application to proliferation & cytotoxicity assays. Journal of Immunolgical Methods 65, 55-63] shows the results of cytotoxicity test in Table 8.

TABLE 8

^a IC _50: Inhibitory Concentration 50, 50% cell killing concentration

As shown in Table 8, the IC ₅₀ value of the STO of the present invention was 10.0, indicating that the cytotoxicity was 2,000 times lower than that of sodium lauryl sulfate, indicating excellent safety. And it showed a similar level of cytotoxicity as squalane, a useful oil with excellent stability.

Experimental Example 6 Cytotoxicity Test 2.

Acute or chronic toxicity test.

Experimental animal: SPF SD rat.

Gender and age: females. cock. 4 weeks old

After purchase, put it in the laboratory for 1 week to observe the symptoms and use only healthy animals.

Number of animals: 5 male and female.

Period of observation Feed: Solid feed and mineral water for experimental animals.

Skin coating material: STO-B and STO-S as products prepared according to the examples.

Application Method: Apply directly to skin after hair removal.

10 hours after application, wash and dry again.

Application period: 30 days

The composition of the test group: 2 STO-B, 3 STO-S.

Test Methods :

One). General State Observation and Mortality Observation

General observation is performed once every hour on the day of application, and the day after application is carefully observed for changes in general condition, poisoning symptoms, mobility, appearance, autonomic nerves and the presence of dead animals.

2). Check weight every 10 days after application.

3). At the end of the test, all animals were visually examined by bleeding live animals with ether anesthesia.

Clinical results: No evidence of death. Momentum loss was observed immediately after application but recovered immediately and no change in body weight.

Autopsy Findings: No significant gross abnormal findings were observed in the autopsy of all surviving animals, presumably due to prolonged skin contact with the test substance.

Experimental Example 7 Allergy Evaluation (LLNA)

As an experiment for confirming whether the composition STO of the present invention is allergic, an acetone: olive oil (4: 1) was used as a transport medium. [Kimber I (1990): Identification of contact allergens using the murine local lymph node assay, J. Appl. Toxicol. 10 (3); 173-180]. The herbal extracts were prepared in 20%, 40%, and 60% solutions, and 50 μl of each of the mice (Balb / c) was applied to each ear for 3 days, and then isolated from the rats. Lymph nodes were pulverized into a single cell state and incubated for 24 hours with the addition of radioisotope (3H-thymidine), and then the amplification degree [cpm] of the cells was measured and the results are shown in Table 9.

TABLE 9

As shown in Table 9, the STO of the present invention showed that the amplification degree (S.I) is 3 or less, and thus there is little possibility of allergic induction.

Experimental Example 8 Skin Irritant Test

Patch test using a guinea pig (Guinea Pig) was performed for the skin irritation test of the present invention STO. [Reference: ①Draize, J.H. (1959): Dermal toxicity. Assoc. Food and Drug officials, US. Appraisal of the safety of chemicals in Food, Drugs and Cosmetics., Pp46-59, Texas State Dept of Health, Austin Texas. Federal Register (1973): Method of testing primary irritant substances 38 (187): pp 1500-1541]. Samples were tested by preparing oil-in-water emulsions of various concentrations of STO.

First, remove the hair from the sample application area (back) and adjust the environment for 24 hours to minimize skin irritation, and then set the sample application area (1.5cm x 1.5cm) to apply the sample and gauze, and then evaporate and lose the sample. In order to prevent the sealing with solid paper and fixed with an elastic bandage for 48 hours. 2 hours and 24 hours after removal of the closed patch, the degree of stimulation was determined and the results are shown in Table 10.

TABLE 10

PII: Primary cutaneous Irritation Index

As shown in Table 10, STO is very safe, and it can be seen that there is little skin irritation even when used excessively, such as 30%.

Experimental Example 9 Primary Irritant Test on the Human Body (Closed Info)

In order to determine the safety of a sample containing 1.0% STO, 1.0% sodium laurylselperate and 10% ethanol, and a solution of 1.0% sodium laurylselperate and 10% ethane, The first stimulation test was performed on the human body through the patch test. Forty healthy men and women were tested according to CTFA guidelines (The Cosmetic, Toility and Fragrance Association. Inc. Washington, D.C., 20O36, 1991). 20 ml of the sample and the solution were added dropwise to a Fin chamber, and it was placed on the back of the human body, which was the test site, and fixed with tape. Subsequently, after patching for 24 hours, after removing the patch and passing 4 hours again, the skin reaction of the test site was determined according to the following criteria, and the results are shown in Table 11.

< Criteria >

-; No erythema or unusual symptoms

±; Slightly redder than the surroundings

+; Significantly redder than the surroundings

++; Severe redness and swelling than around

Stimulus = [{(±) Number x 1} + {(+) Number x 2} + {(++) Number x 3}] / Number of Subjects

Table 11

As shown in Table 11, 1.0% of STO significantly reduced the stimulation of 10% of sodium lauryl sulfate and 1.0% of ethane. These results are believed to be due to the excellent anti-inflammatory effect of STO as shown in the anti-inflammatory effect test described above. From these experimental examples, it can be seen that STO has an excellent anti-inflammatory effect and is safe for skin.

Experiment 10.

Experimental Example for Clinical Validation.

Atopic dermatitis 12. Dry ringworm. Ring limbs. Antiphasic vesicle ringworm. Various eczema. Malignant acne (acne). Itching of the skin. Shingles. psoriasis. Chronic skin condition. Purulent diseases, such as palmar ulcer vesicles. Ten athletes with athlete's foot are sprayed with liquid on the skin disease area, and then lightly patted and rubbed with rubbing massage, and then dried.

Shingles : Massaging twice daily morning and afternoon. Massage twice or more daily to apply massage for 6 days. The improvement effect among those with skin of the disease is the effect of partial improvement of two people. Ease of near eight is perfection.

Seven people with chronic atopic disease skin was massaged by applying the composition of the present invention three times a day.

RESULTS: On days 3 to 5, there was a pronounced alleviation effect. After 10 days, the skin was completely improved. After 25 days, the damaged skin was completely regenerated.

Three people with early atopic disease skin were applied twice daily and massaged.

RESULTS: Itching disappeared immediately after the application of massage, once a day after 6 days, once every 3 days after 10 days, and after 30 days, the massage was completely improved.

The composition of the present invention was applied twice a day to two children's skins of the third year of atopic disease and massaged.

RESULTS: The massage did not immediately feel itching. After 2 days of massage, the erythema disappeared and the applied massage was stopped at 15 days with complete improvement.

Palmar pustules : Palms like cowhide, cracked, bleeding, and sore skin disease 3rd year, 3rd year, 1st year, 5th year, 5th year, 1st year The composition was applied 3-4 times a week and massaged.

RESULTS: After a week, the dark skin disease area turned red, the skin softened and softened, and it was completely improved in 65-90 days, respectively.

Athlete's foot : A skin massage applied to the composition of the present invention twice daily for 16 days to a skin patient damaged by foot's foot for 3-7 years.

RESULTS: On day 10, complete normal skin was obtained.

Massage was performed on the skin of dry ringworm and bullous ringworm for 18 days.

Result: Complete skin regeneration.

The skin was massaged for 12 days.

RESULTS: The pruritic symptoms improved completely within 10 minutes after application.

Blister-like blisters on the hands and itching was rubbed on the skin of the housewife's eczema three times a day. After 10 minutes of massage, the blisters disappeared and the itch disappeared.

The blisters on the upper body were caused by shingles and treated with B6, but they were cured on day 3 by applying twice a day to the affected skin.

In addition, there are many cases of clinical practice in which over 99% of all skin diseases such as acne, skin pruritus, psoriasis, ringworm, umbilical cord hypopyremia and malignant athlete's foot are cured.

The mechanism of the improvement function of the damaged skin and the skin regeneration function of the composition of the skin disease improvement functional cosmetics of the present invention are as follows.

Action of the composition STO of the present invention on skin diseases

The composition of the present invention penetrates deeply into the diseased cells and the cells around the disease, destroys the protective film of bacteria consisting of impurities generated in response to bacterial infiltration, and starts bactericidal action on the causative bacteria of the disease. It surrounds damaged skin and continuously sterilizes it, and is involved in the regeneration of damaged cells to promote blood circulation and physiological activity. It is involved as a mediator in the very complex reactions that connect cells and substrates around cells, and in order for wounds to heal, it is necessary to repair the wounds and supply nutrients through new tissues. It quickly regenerates cells with angiogenesis, which promotes angiogenesis. In addition, it is a serious disease on the skin. It is involved in exfoliation of the skin covered with thick keratin and removes keratin to remove keratin so that the active substance penetrates deeply into the cells of the disease site, and removes toxins caused by bacteria in the disease site. Eliminates pain, itching

According to the composition of the skin disease improving functional cosmetics of the present invention,

Atopic dermatitis. Dry ringworm. Ring limbs. Antiphasic vesicle ringworm. Various eczema. Malignant acne. Itching of the skin. Shingles. psoriasis. Chronic skin condition. Intestinal foot hypochondria. Fungal athlete's foot. It has the effect of improving the disease area of the skin with various diseases such as malignant swelling to completely normal skin, the period of improvement to normal skin is short, and there is no side effect caused by the skin's rejection of the composition with non-toxicity. It does not leave a scar on the repair of damaged skin, it enhances the blood circulation system of the skin, promotes skin metabolism, eliminates itching, makes skin shine, maintains moisture, reduces oily cortex, shrinks pores It converts into elastic skin, thereby suppressing the occurrence of wrinkles.

Claims (11)

The composition of the cosmetic composition having an auxiliary function of treating a kind of skin disease comprises silver, sulfur, aspirin, alum, rosin, potassium hydroxide, glycerin, and distilled water . The proportion of the composition of the cosmetic composition having an auxiliary function of treating skin diseases according to claim 1 is 5% -20% of an aqueous solution of an electro-colloidal silver having a purity of 99.99%, a concentration of 0.1ppm to 50ppm, and a grain size of 2-15nm in% to the total weight of the composition. And aspirin 0.001% -0.1%, sulfur 0.001% -0.2%, rosin 0.01% -0.15%, potassium hydroxide 0.3% -3%, alum 0.5% -3%, glycerin 5% -60% A composition of the auxiliary functional cosmetics for the treatment of skin diseases, characterized in that. The composition of the cosmetic composition having an auxiliary function of treating skin diseases according to claim 1, wherein the composition is formed in a liquid, ointment or cream form, and the liquid composition is a mixture of aloe extract, safflower extract, yellowish white extract, fragrance, distilled water or alcohol . The composition of 1 is added to the composition, the composition of the ointment or cream is a composition comprising the composition of claim 1 added to the mixture of emulsifiers, aloe extract, gypsum, fiber, pearl powder and zeolite, sulfur white extract, fragrance, distilled water A composition of auxiliary functional cosmetics for the treatment of skin diseases. The proportion of the composition of the liquid composition according to claim 3 is a weight ratio of brewing alcohol having a concentration of 20% -99% or a purity of 99.99% with a concentration of 0.1 ppm-50 ppm, silver ionized water having a particle of 2-15 nm, or 100Og of a mixture of the alcohol and silver ionized water. As aloe extract 20g-100g. 1 g-10 g of extract of safflower . Sulfur extract 10g-60g, aspirin (acetylsalicylic acid) 0.01g-1g. Sulfur 0.01 g-1 g. Alum 5g-30g. Rosin 0.1 g-1.5 g. A composition of a functional cosmetic composition for treating skin diseases, characterized in that the composition is composed of a mixture of glycerin 100g-350g, potassium hydroxide 3g-30g, cholesterol 10g-30g, fragrance 0.001g-0.1g. The compositional proportion of the ointment or cream according to claim 3 is 0.1% to 60% of any one or any of a plurality of mixed emulsifiers of a general-purpose emulsifier comprising stearic acid in a total weight composition ratio. Aloe Extract 5% -15%. Aspirin (acetylsalicylic acid) 0.001% -0.1%, alum (alum) 0.5% -3%, sulfur 0.001% -0.1%, rosin 0.01% -0.15%, cholesterol 3% -5%, glycerin 5% -60%, hydroxide Potassium 0.05% -3%, gypsum 0.8-2.5%, fiber 0.02% -0.1%, pearl powder and zeolite 0.5% -5%, white and white extract 1.5% -5%, fragrance 0.001% -0.005%, purity 99.99% or more 0.1 ppm-50 ppm, the composition of the skin disease treatment auxiliary functional cosmetics, characterized in that the composition consisting of 5% -20% silver ion water of particles 2-15nm. 3. The composition of any one of claims 5, wherein the composition of the liquid composition and the ointment or cream comprises a general purpose herbal extract , general purpose seaweed extract , general purpose animal in a composition composed according to any one of claims 1 to 5. Extracts , general purpose minerals or mineral extracts , any one or more than two or more substances selected from general-purpose chemicals , and any one or more than two or more substances selected from each of these substances are added and mixed to aid in treating skin diseases The composition of the auxiliary functional cosmetics for the treatment of skin diseases, characterized in that the functional composition can be configured. 3- Claim 4. The auxiliary functional cosmetic liquid composition of claim 6 for treating skin diseases 1. Mix safflower extract, aloe extract and yellowish white extract with alcohol or distilled water to make a mixed solution of aloe extract and safflower extract, 2. Add rosin to alcohol or glycerin to dissolve to obtain a mixture of glycerin and rosin, 3. Dissolve potassium hydroxide, alum and aspirin with silver ionized water and distilled water to make a mixed solution. 4. Dissolve sulfur in alkaline aqueous solution to get an aqueous solution, And mixing the four solutions to produce a liquid composition. Claim 3, 5, 6 of the auxiliary functional cosmetic composition for the treatment of skin diseases in the form of ointment or cream, 1. Put emulsifier into the container and heat it, 2. Dissolve rosin, aspirin, sulfur and cholesterol in glycerin to obtain a lysate. 3. Mix potassium hydroxide, yellow white extract, gypsum, fiber, pearl powder with distilled water containing silver ionized water, 4. Mix the melt of cholesterol, rosin, sulfur and aspirin with the heated emulsifier and heat it to cool, 5. Aloe extract and spices are added to the cooled mixture and heated to a mild temperature. Composition of the auxiliary functional cosmetics for the treatment of skin diseases, characterized in that the composition prepared by the above process. The auxiliary functional cosmetic composition of the skin disease treatment of claim 3, 5, 6, 1. Glycerin, stearic acid, cholesterol, and rosin are mixed and dissolved by heating, 2. Mix potassium hydroxide, aspirin, sulfur white, water soluble sulfur, gypsum, fiber and pearl powder with silver ionized water to make mixed solution, 3. After heating by mixing the silver ion water mixed solution to the heated and dissolved mixture, 4. A process for preparing skin disease improvement functional composition by adding aloe extract and fragrance and heating with mild heat; Composition of the auxiliary functional cosmetics for the treatment of skin diseases, characterized in that the composition prepared by the above process. The auxiliary functional cosmetic composition of the skin disease treatment of claim 3, 5, 6, 1.Imperate zeolite in mixed aqueous solution made by dissolving sulfur, potassium hydroxide and aspirin in silver ionized water to infiltrate the aqueous solution of the mixture into the zeolite pores, 2. Mix emulsifier, cholesterol, yellow white extract, and rosin with glycerin and heat to obtain a mixed solution. 3. A process of preparing a composition by heating a mixture of the two mixtures and a mixture of pearl powder, gypsum, fiber, aloe extract, and perfume, Composition of the auxiliary functional cosmetics for the treatment of skin diseases, characterized in that the composition prepared by the above process. 3. The composition of claim 10, wherein the composition of the liquid composition, ointment or cream can be used as a therapeutic agent for skin diseases of the human body or various animals.