CN108671059A - A kind of liquid and preparation method thereof for treating onychomycosis - Google Patents
A kind of liquid and preparation method thereof for treating onychomycosis Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
This programme discloses a kind of liquid for treating onychomycosis in onychomycosis treatment technology field, including raw material and its volume parts be：30~60 parts of 5~15 parts of Golden Larch Bark ethyl alcohol soak, 5~15 parts of favus skin ethyl alcohol soak, 5~30 parts of Cortex Phellodendri ethyl alcohol soak, 5~15 parts of radix scutellariae ethyl alcohol soak, 5~15 parts of coptis ethyl alcohol soak and wormwood essential oil.When preparation, each raw material is first impregnated using ethanol solution, and the ethyl alcohol soak of each raw material, which is then mixed to prepare onychomycosis, by volume parts treats liquid.The liquid prepared in this programme, by using wormwood essential oil as bleeding agent so that the active ingredient in liquid is diffused into nail bottom from nail surface quickly, also keeps each fraction medicine effective concentration of nail matrix, it helps to restore nail gloss simultaneously, significantly improves the treatment speed and effect to onychomycosis.
Description
Technical field
The invention belongs to onychomycosis treatment technology field, more particularly to a kind of liquid for treating onychomycosis and its preparation side
Method.
Background technology
Onychomycosis is also known as onychomycosis, refers to that the fungies such as dermatophytes invade disease caused under deck or first.Onychomycosis at present
Therapeutic modality there are mainly three types of：First, endo-medicine and Topical therapy are pulled out in operation；Wherein, operation pulls out first since the surface of a wound is big, Yi Yin
The problems such as playing infection, being easy to re-infect recurrence, clinical less use.Endo-medicine is since dosage is big, administration time
The problems such as long, sterilizing is not thorough and is easy recurrence, utilization rate is not also high.And Topical therapy is easy to operate, and almost to any trouble
Person is applicable in, and therefore, Topical therapy is used widely.Topical therapy generally use Terbinafine tincture, Amorolfine first liniment,
The antimycotic externally applied drug partial smearings such as Ciclopirox Olamine ketone first paint, which irritation is strong, and toxic side effect is big, newly longer finger
First carries the germs of a disease so being easy recurrence, and clinic also seldom uses at present.In addition, being applied outside using 30 parts of glacial acetic acid or 10 parts of glacial acetic acid
The sick first of bubble is also to treat the common therapeutic modality of onychomycosis, and which has very strong and stimulating gas due to glacial acetic acid and salicylic acid
Taste, and it is big to patient skin irritation, and treatment time is long, patient is not easily accepted by.
In view of the above-mentioned problems, application No. is CN00126761.2, patent name is a kind of " medicine for treating onychomycosis (onychomycosis)
The patent of agent and preparation method thereof " discloses a kind of drug for treating onychomycosis, includes mainly vinegar (or acetic acid), allicin, hardship
Ginseng, public fourth, Chinese gall, giant knotweed and frutus cnidii；Since vinegar (or acetic acid) and allicin all have stronger stimulation in the monarch drug in a prescription of use
Property, stronger to patient skin irritation, usage experience is bad；In addition, the drug in the formula is relatively low to the osmosis of nail,
It needs to remove sick first before use and can just play preferable therapeutic effect, otherwise therapeutic effect will have a greatly reduced quality.
Invention content
The invention is intended to provide a kind of liquid for treating onychomycosis, oozed with solving onychomycosis medicine in the prior art
Permeability is poor and irritation is larger, leads to the problem that therapeutic effect is bad.
A kind of liquid for treating onychomycosis in this programme, including raw material and its volume parts be：Golden Larch Bark ethyl alcohol soaks
Steep 5~15 parts of liquid, 5~15 parts of favus skin ethyl alcohol soak, 5~30 parts of Cortex Phellodendri ethyl alcohol soak, radix scutellariae ethyl alcohol soak 5~15
30~60 parts of part, 5~15 parts of coptis ethyl alcohol soak and wormwood essential oil.
The advantageous effect of this programme：
Golden Larch Bark：Containing native chaste tree formic acid, native chaste tree acetic acid, native chaste tree propionic acid etc., alcohol extract has very strong anti-trichophyton schoenleini, cotton-shaped
The fungies such as the small gemma tinea bacterium of Epidermophyton, rust, Microsporum gypseum and Candida albicans act on, and anti-fungal mechanism is
Fungal cell's structural degeneration, organelle is set to disappear, the apparent shrinkage of cell membrane, structure of mitochondria is also denaturalized or even disappears, and fungi is thin
Cellular damage degree is related with drug concentration, if drug concentration is enough, has 100% killing effect to fungal cell.
Favus skin：Favus skin has the effect of heat-clearing and damp-drying drug, wind dispelling removing toxic substances, and ethyl alcohol soak is to trichophyton, proper alignment
Trichophyta, oidium schoenleinii, the small gemma tinea bacterium of Du Ang Shi difficult to understand, the small gemma tinea bacterium of rust, the small gemma tinea bacterium of ulotrichy, abdomen stock
A variety of pathogenic fungus such as ditch Epidermophyton, star nocardia have different degrees of inhibiting effect.
Cortex Phellodendri：Have that the effect of heat-clearing and damp-drying drug, purging intense heat dehumidifying, detoxification sore treatment, ethyl alcohol impregnate liquid energy and inhibit the growth of bacterium numerous
It grows, and has unique antifungic action.
Radix scutellariae：Extract contains scutelloside, there is apparent anti-candida albicans, mechanism be by inhibit the DNA of fungi,
The biosynthesis of RNA and protein lead to bacterium cell death.
The coptis：Have that the effect of purging intense heat, removing toxic substances, heat-clearing, eliminating dampness, alcohol extract contain jamaicin, coptisine, jateorrhizine and first
A variety of alkaloids such as base coptisine.
Wormwood essential oil：With rationale blood, warm meridians, dispellieg cold and dampness, analgesic, antibacterial, anti-inflammatory and other effects can be with as bleeding agent
Promote liquid active pharmaceutical ingredient infiltration of the present invention up to the internal nail matrix of nail (toe), and the drug that arrival position can be kept enough is dense
Degree.
Kill effect of this programme by Golden Larch Bark and radix scutellariae to fungi reduces the content of fungi in onychomycosis；Profit simultaneously
With favus skin, Cortex Phellodendri, the coptis, wormwood essential oil and alcohol to the inhibiting effect of fungi, germ, the growth of fungi is further limited；
In addition, favus skin, Cortex Phellodendri and the effect of the heat-clearing and damp-drying drug of the coptis, can significantly improve toenail environment, fungi growth is further suppressed.This
Various drugs in scheme are natural traditional Chinese medicine, and irritation is small, and without toxic side effect, and wormwood essential oil itself is anti-with wide spectrum
Fungi activity has effect to inactivation pathogenic fungus, and wormwood essential oil has good compatibility to nail, the permeability in nail
Speed is fast, helps the active ingredient in liquid to be diffused into nail bottom from nail surface quickly by osmosis, also keeps first
Each fraction medicine effective concentration of bed, while helping to restore nail gloss, significantly improve the treatment speed and effect to onychomycosis.
Further, it is described treatment onychomycosis liquid, including raw material and its volume parts be：Golden Larch Bark ethyl alcohol soak
5~10 parts, 5~10 parts of favus skin ethyl alcohol soak, 5~25 parts of Cortex Phellodendri ethyl alcohol soak, 5~10 parts of radix scutellariae ethyl alcohol soak,
30~40 parts of 5~10 parts of coptis ethyl alcohol soak and wormwood essential oil.Pass through the limitation to each material content so that each material content
It is more balanced, be conducive to the therapeutic effect for improving liquid to onychomycosis.
Further, the liquid of the treatment onychomycosis, raw material further include the clotrimazole that volume parts are 0.1~0.3 part
Ethanol solution.Clotrimazole category pyroles broad-spectrum antifungal medicine, to Trichophyton rubrum, trichophyton gypseum, Cryptococcus neoformans, song
Bacterium, phycomycete, Candida albicans etc. significantly inhibit effect.Mechanism be by the activity of interference cell pigment P~450, to
Inhibit the biosynthesis of the sterol such as fungi ergosterol, damage fungal cell membrane and changes its permeability；Inhibit the glycerine of fungi
The biosynthesis of three fat and phosphatide；The activity for inhibiting oxidizing ferment and peroxidase causes the accumulation of fungal cell's hydrogen peroxide to be led
Cause the denaturation of cell submicroscopic structure and meronecrosis.The addition of clotrimazole ethanol solution is conducive to improve liquid to onychomycosis fungi
The curative effect killed range, improve to onychomycosis.
The preparation method of the drug of the treatment onychomycosis, includes the following steps：
Step 1: Golden Larch Bark ethyl alcohol soak：Dry 500~550g of the Golden Larch Bark prepared slices of Chinese crude drugs is immersed in 1000ml matter
It measures in a concentration of 65~75% ethanol solution, is kept in dark place 20~35 days, filter to obtain Golden Larch Bark ethyl alcohol soak；
Step 2: favus skin ethyl alcohol soak：Dry 500~550g of the favus skin prepared slices of Chinese crude drugs is immersed in 1000ml matter
It measures in a concentration of 65~75% ethanol solution, is kept in dark place 20~35 days, filter to obtain favus skin ethyl alcohol soak；
Step 3: Cortex Phellodendri ethyl alcohol soak：It is dense that dry 500~600g of the Cortex Phellodendri prepared slices of Chinese crude drugs is immersed in 1000ml mass
In the ethanol solution that degree is 65~75%, it is kept in dark place 20~35 days, filters to obtain Cortex Phellodendri ethyl alcohol soak；
Step 4: radix scutellariae ethyl alcohol soak：It is dense that dry 500~550g of the radix scutellariae prepared slices of Chinese crude drugs is immersed in 1000ml mass
In the ethanol solution that degree is 65~75%, it is kept in dark place 20~35 days, filters to obtain radix scutellariae ethyl alcohol soak；
Step 5: coptis ethyl alcohol soak：It is dense that dry 500~550g of the coptis prepared slices of Chinese crude drugs is immersed in 1000ml mass
In the ethanol solution that degree is 65~75%, it is kept in dark place 20~35 days, filters to obtain coptis ethyl alcohol soak；
Step 6: clotrimazole ethanol solution：10~20g of clotrimazole is taken, it is 65~75% that 1000ml mass concentrations, which are added,
In ethanol solution, stirring and dissolving to obtain the final product；
Step 7: by the proportioning of each raw material in the liquid for the treatment of onychomycosis by Golden Larch Bark ethyl alcohol soak, favus skin ethyl alcohol
Soak, Cortex Phellodendri ethyl alcohol soak, radix scutellariae ethyl alcohol soak, coptis ethyl alcohol soak, clotrimazole ethanol solution and wormwood essential oil
It is mixed and stirred for uniformly obtaining the liquid for the treatment of onychomycosis.
Each raw material is prepared by the way of ethyl alcohol immersion so that the beneficiating ingredient of various drugs is dissolved into ethanol solution,
Ethanol solution itself is inhibited to onychomycosis fungi simultaneously, and then significantly improves liquid made from the later stage to onychomycosis
Therapeutic effect.
Further, for the step 1 in five, the time of being kept in dark place of each drug is 30 days.It is kept in dark place 30 days, has
It is fully dissolved into ethanol solution conducive to the active ingredient in drug, while the ethyl alcohol soak in turn avoiding preparing becomes
Matter.
Further, for the step 1 in five, the mass concentration of ethanol solution is 70%.It is 70% to select mass concentration
Ethanol solution, on the one hand 70% ethanol solution help to kill the germ in ethyl alcohol soak, avoid it rotten, another party
Face is conducive to nutriment in drug and enters in ethanol solution.
Description of the drawings
Fig. 1 is used to treat the design sketch of onychomycosis for the liquid for the treatment of onychomycosis obtained in the embodiment of the present invention 1；
Fig. 2 is used to treat the design sketch of onychomycosis for the liquid for the treatment of onychomycosis obtained in the embodiment of the present invention 2；
Fig. 3 is used to treat the design sketch of onychomycosis for the liquid for the treatment of onychomycosis obtained in the embodiment of the present invention 3.
Specific implementation mode
Below by the further details of explanation of specific implementation mode：
One, the preparation of the liquid of onychomycosis is treated
Embodiment 1：
A kind of preparation method of liquid that treating onychomycosis, it is characterised in that：Include the following steps：
Step 1: Golden Larch Bark ethyl alcohol soak：It is dense that dry Golden Larch Bark prepared slices of Chinese crude drugs 500g is immersed in 1000ml mass
In the ethanol solution that degree is 70%, it is kept in dark place 30 days, filters to obtain Golden Larch Bark ethyl alcohol soak；
Step 2: favus skin ethyl alcohol soak：It is dense that dry favus skin prepared slices of Chinese crude drugs 500g is immersed in 1000ml mass
In the ethanol solution that degree is 70%, it is kept in dark place 30 days, filters to obtain favus skin ethyl alcohol soak；
Step 3: Cortex Phellodendri ethyl alcohol soak：Dry Cortex Phellodendri prepared slices of Chinese crude drugs 500g, which is immersed in 1000ml mass concentrations, is
It in 70% ethanol solution, is kept in dark place 30 days, filters to obtain Cortex Phellodendri ethyl alcohol soak；
Step 4: radix scutellariae ethyl alcohol soak：Dry radix scutellariae prepared slices of Chinese crude drugs 500g, which is immersed in 1000ml mass concentrations, is
It in 70% ethanol solution, is kept in dark place 30 days, filters to obtain radix scutellariae ethyl alcohol soak；
Step 5: coptis ethyl alcohol soak：Dry coptis prepared slices of Chinese crude drugs 500g, which is immersed in 1000ml mass concentrations, is
It in 70% ethanol solution, is kept in dark place 30 days, filters to obtain coptis ethyl alcohol soak；
Step 6: clotrimazole ethanol solution：Clotrimazole 10g is taken, the ethanol solution that 1000ml mass concentrations are 70% is added
In, stirring and dissolving to obtain the final product；
Step 7: 10ml Golden Larch Bark ethyl alcohol soak, 10ml favus skin ethyl alcohol soak, 15ml Cortex Phellodendri ethyl alcohol are impregnated
Liquid, 10ml radix scutellariae ethyl alcohol soak, 10ml coptis ethyl alcohol soak, 0.2ml clotrimazoles ethanol solution and 43ml wormwood essential oils are mixed
Merge the liquid for stirring evenly and obtaining treatment onychomycosis.
Embodiment 2 the difference is that only with embodiment 1：When preparing liquid, the dosage of each raw material is：Golden Larch Bark ethyl alcohol
Soak 7ml, favus skin ethyl alcohol soak 5ml, Cortex Phellodendri ethyl alcohol soak 10ml, radix scutellariae ethyl alcohol soak 7ml, the leaching of coptis ethyl alcohol
Steep liquid 8ml, clotrimazole ethanol solution 0.3ml and wormwood essential oil 60ml.
Embodiment 3 the difference is that only with embodiment 1：When preparing liquid, the dosage of each raw material is：Golden Larch Bark ethyl alcohol
Soak 5ml, favus skin ethyl alcohol soak 15ml, Cortex Phellodendri ethyl alcohol soak 25ml, radix scutellariae ethyl alcohol soak 15ml, coptis ethyl alcohol
Soak 5ml, clotrimazole ethanol solution 0.1ml and wormwood essential oil 34ml.
Embodiment 4 the difference is that only that the mass concentration of ethanol solution is when preparing ethyl alcohol soak with embodiment 1
65%.
Embodiment 5 the difference is that only that the mass concentration of ethanol solution is when preparing ethyl alcohol soak with embodiment 1
75%.
Comparative example 1 the difference is that only with embodiment 1, and wormwood essential oil is lacked in liquid.
Comparative example 2 the difference is that only with embodiment 1, and clotrimazole ethanol solution is lacked in liquid.
Comparative example 3 the difference is that only with embodiment 1, and wormwood essential oil and clotrimazole ethanol solution are lacked in liquid.
Comparative example 4 is using application No. is the methods in the patent of CN00126761.2 to prepare drug.
Examples 1 to 5 is identical with the application method of the liquid for the treatment of onychomycosis obtained in comparative example 1~3, with embodiment
For 1, in use, sick first is not required to pre-processing, dry onychomycosis surface will be coated in outside liquid sooner or later daily, each coating needs
It keeps nail surface in 8 minutes to there is liquid to be in moisture state, cleans coating nail, adult's continuous use after each medication immediately
8 days, child's continuous use 5 days, after being discontinued 20 days again continuous use after treatment in 2~6 days (to patients with mild continuous use 2 again
~3 days, continuous use 3~5 days, severe patient or onychomycosis thickness were continuous again more than 3 times of normal nail or more again by moderate patient
Medication 5~6 days), the purpose of after treatment is to kill to remain fungi in nail matrix, is recurred after preventing Rehabilitation.Comparative example 4 presses Shen
Please number for CN00126761.2 patent disclosed in method treated.
Two, clinical effectiveness：
Using the liquid medicine applying onychomycosis patient prepared in Examples 1 to 5 and comparative example 1~4.
1. general information：Onychomycosis：(the liquid medicine applying prepared using Examples 1 to 5 and comparative example 1~3 of patient 288
Onychomycosis patient；32 people of each liquid medicine applying)；
2. diagnostic criteria
Onychomycosis：Yellow plate first；Melanonychia；Divergence type onychomycosis；Keratinization type, incrassation type deck；Deficient onychomycosis；Fissility
Onychomycosis.
3. therapy (Examples 1 to 5 and comparative example 1~3)
Coating method is will to be coated in dry onychomycosis surface outside liquid, wait for that medicinal liquid osmosis is complete, i.e. coating nail surface drying
After supplement coating, keep nail surface to have liquid moisture state 8 minutes, clean the residual medicine of coating nail surface immediately after
Liquid.It strictly presses the medication of coating method twice sooner or later daily, is used continuously 8 days, continuously press coating method medication 3 after being discontinued 20 days again
It is killed in nail matrix and remains fungi, is recurred after avoiding rehabilitation.
4. efficacy assessment standard
It cures：It is healthy nail to grow new first, and onychomycosis is taken off completely within 120 days or so, without recurrence after rehabilitation half a year.
5. the results are shown in table below：
| Group | It cures (people) | Effectively (people) | It recurs (people) |
| Embodiment 1 | 32 | 0 | 0 |
| Embodiment 2 | 31 | 1 | 0 |
| Embodiment 3 | 31 | 1 | 0 |
| Embodiment 4 | 32 | 0 | 0 |
| Embodiment 5 | 32 | 0 | 0 |
| Comparative example 1 | 28 | 4 | 3 |
| Comparative example 2 | 30 | 2 | 0 |
| Comparative example 3 | 26 | 6 | 4 |
| Comparative example 4 | 27 | 5 | 5 |
In upper table, healing represents onychomycosis patient and fully recovers in 120 days for the treatment of, effectively refers to liquid and suffers to onychomycosis
Person is effective in 120 days for the treatment of, but does not fully recover.
As seen from the table, the liquid that prepared by Examples 1 to 5 all has good therapeutic effect to onychomycosis, and almost
It will not recur；The main reason for comparative example 1 and comparative example 3 more serious relative to Examples 1 to 5 recurrence, has been the absence of wormwood essence
The addition of oil so that the amount that liquid enters nail matrix substantially reduces, and then affects therapeutic effect and progress.
Patient strictly presses therapy medication using the liquid of the present invention, it is observed that the new nail grown and health
Nail is the same, and sick first is replaced by healthy nail completely within 120 days or so, and without recurrence after rehabilitation half a year, liquid of the invention is complete
The various pathomycetes in onychomycosis can be killed entirely, strictly newly grow nail by being had no after the Rehabilitation of therapy medication
It is infected by pathomycete.
6. case
It is three cases chosen in numerous actual therapeutic cases below.
Case one (is treated, therapeutic effect such as Fig. 1) using the liquid of embodiment 1：Patient Ms Zhang, 30 years old, left foot
Thumb suffers from onychomycosis, and nail is muddy, thickens, surface irregularity, changes colour, suffers from onychomycosis 5 years, and multi-treatment does not have rehabilitation,
Using the liquid of the present invention, strictly by therapeutic scheme medication 8 days, continuous use 3 days again after being discontinued 20 days, the new nail grown with
For health without two, rebound phenomenon is not observed after half a year in rehabilitation.
Case two (is treated, therapeutic effect such as Fig. 2) using the liquid of embodiment 2：Mr. Wang, man, 38 years old, professional kitchen
Teacher suffers from onychomycosis 2 years, and multi-treatment is invalid, has 4 finger nails to suffer from onychomycosis inflammation for many years, and deck convex-concave is random, and deck lacks
Damage, cuticula thicken, multiple performances such as nail matrix deformation, using liquid of the present invention, strictly by therapeutic scheme medication 8 days, drug withdrawal 20
Continuous use 5 days again after it, it is healthy finger nail to have grown new nail, and rebound phenomenon is not observed in half a year.
Case three (is treated, therapeutic effect such as Fig. 3) using the liquid of embodiment 3：Mrs Ou 37 years old, there is family history
Trick onychomycosis, totally 8 suffer from divergence type deck onychomycosis, and deck thickens blackening, and rough and uneven in surface random disease is detached with nail matrix
Become.Though it is invalid through multi-treatment, using the invention liquid, strictly by therapeutic scheme medication 8 days, continuous use again after being discontinued 20 days
5 days, it was healthy nail hand to have grown new nail, cures year and a day and rebound phenomenon is not observed.
Claims (6)
1. a kind of liquid for treating onychomycosis, it is characterised in that：Including raw material and its volume parts be：Golden Larch Bark ethyl alcohol impregnates
5~15 parts of liquid, 5~15 parts of favus skin ethyl alcohol soak, 5~30 parts of Cortex Phellodendri ethyl alcohol soak, radix scutellariae ethyl alcohol soak 5~15
30~60 parts of part, 5~15 parts of coptis ethyl alcohol soak and wormwood essential oil.
2. the liquid for the treatment of onychomycosis according to claim 1, it is characterised in that：Including raw material and its volume parts
For：5~10 parts of Golden Larch Bark ethyl alcohol soak, 5~10 parts of favus skin ethyl alcohol soak, 5~25 parts of Cortex Phellodendri ethyl alcohol soak, radix scutellariae
30~40 parts of 5~10 parts of ethyl alcohol soak, 5~10 parts of coptis ethyl alcohol soak and wormwood essential oil.
3. the liquid for the treatment of onychomycosis according to claim 1 or 2, it is characterised in that：The liquid of the treatment onychomycosis,
Its raw material further includes the clotrimazole ethanol solution that volume parts are 0.1~0.3 part.
4. the preparation method of the liquid for the treatment of onychomycosis according to claim 3, it is characterised in that：Include the following steps：
Step 1: Golden Larch Bark ethyl alcohol soak：It is dense that dry 500~550g of the Golden Larch Bark prepared slices of Chinese crude drugs is immersed in 1000ml mass
In the ethanol solution that degree is 65~75%, it is kept in dark place 20~35 days, filters to obtain Golden Larch Bark ethyl alcohol soak；
Step 2: favus skin ethyl alcohol soak：It is dense that dry 500~550g of the favus skin prepared slices of Chinese crude drugs is immersed in 1000ml mass
In the ethanol solution that degree is 65~75%, it is kept in dark place 20~35 days, filters to obtain favus skin ethyl alcohol soak；
Step 3: Cortex Phellodendri ethyl alcohol soak：Dry 500~600g of the Cortex Phellodendri prepared slices of Chinese crude drugs, which is immersed in 1000ml mass concentrations, is
It in 65~75% ethanol solution, is kept in dark place 20~35 days, filters to obtain Cortex Phellodendri ethyl alcohol soak；
Step 4: radix scutellariae ethyl alcohol soak：Dry 500~550g of the radix scutellariae prepared slices of Chinese crude drugs, which is immersed in 1000ml mass concentrations, is
It in 65~75% ethanol solution, is kept in dark place 20~35 days, filters to obtain radix scutellariae ethyl alcohol soak；
Step 5: coptis ethyl alcohol soak：Dry 500~550g of the coptis prepared slices of Chinese crude drugs, which is immersed in 1000ml mass concentrations, is
It in 65~75% ethanol solution, is kept in dark place 20~35 days, filters to obtain coptis ethyl alcohol soak；
Step 6: clotrimazole ethanol solution：10~20g of clotrimazole is taken, the ethyl alcohol that 1000ml mass concentrations are 65~75% is added
In solution, stirring and dissolving to obtain the final product；
Step 7: Golden Larch Bark ethyl alcohol soak, favus skin ethyl alcohol are impregnated by the proportioning of each raw material in the liquid for the treatment of onychomycosis
Liquid, Cortex Phellodendri ethyl alcohol soak, radix scutellariae ethyl alcohol soak, coptis ethyl alcohol soak, clotrimazole ethanol solution and the mixing of wormwood essential oil
And stir evenly the liquid for obtaining treatment onychomycosis.
5. the preparation method of the liquid for the treatment of onychomycosis according to claim 4, it is characterised in that：The step 1 is to five
In, the time of being kept in dark place of each drug is 30 days.
6. the preparation method of the liquid for the treatment of onychomycosis according to claim 4 or 5, it is characterised in that：The step 1
Into five, the mass concentration of ethanol solution is 70%.
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Application publication date: 20181019 |