CN110200901A - A kind of cream preparation that treating subacute eczema and preparation method - Google Patents
A kind of cream preparation that treating subacute eczema and preparation method Download PDFInfo
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- CN110200901A CN110200901A CN201910513599.1A CN201910513599A CN110200901A CN 110200901 A CN110200901 A CN 110200901A CN 201910513599 A CN201910513599 A CN 201910513599A CN 110200901 A CN110200901 A CN 110200901A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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Abstract
The invention belongs to pharmaceutical preparation preparation fields, and in particular to a kind of cream preparation for treating subacute eczema and preparation method.The cream preparation of the treatment subacute eczema includes following component: 100~306g of nano zine oxide, 118~200g of starch, 110~280g of lanolin, 30~90g of shrubby sophora extract, 25~80g of garlic P.E, 10~50g of purslane extract, 800~1268g of emulsifiable paste matrix；The cream preparation component for the treatment of subacute eczema prepared by the present invention is simpler, has the effects that soak antipruritic, anti-inflammation detumescence, antiallergy.
Description
Technical field
The invention belongs to pharmaceutical preparation preparation fields, and in particular to a kind of cream preparation for treating subacute eczema and preparation
Method.
Background technique
Eczema be as caused by the inside and outside factor of Various Complex it is a kind of with pleomorphism skin lesion and tend to have exudation tendency skin
Skin inflammatory reaction.It is divided into acute, subacute and three kinds of chronic eczema by skin lesion characteristicness.Acute eczema is that most grain grains are big
Red papules, papulo-vesicle or blister still have obvious dotted or strip rotten to the corn, sepage, incrustation；It may occur in which purulence when concurrent infection
Blister, purulence exudation and scab bits etc..Chronic eczema more have acute, subacute eczema repeatedly not more be transformed, skin lesion be it is dark red or
Reddish brown color spot or maculopapule, permelting conjunction thicken in lichenification, there are the scales of skin that peel off, scratch and scab in surface, be around dispersed in a small number of papules,
Maculopapule etc.；Skin lesion can acute attack under certain inducement.
Subacute eczema is a transition stage among acute eczema and chronic eczema.Subacute eczema is in urgency
Property eczema inflammation mitigate after or acute stage proper treatment not in time, stall for time and subacute eczema relatively occur long.Skin lesion with
Based on small papule, the scales of skin that peel off and incrustation, only minority papulo-vesicles or phlysis and erosion can also have mild infiltration, consciously still there is play
Strong itch.Easy recurrent exerbation.It can convert mutually, not recover for a long time between acute eczema, chronic eczema.It has a characteristic that
(1) pleomorphism: when subacute eczema suffers from hair, the form of skin lesion symptom has multiple, and can be divided into primary eczema
With excitation eczema.It will appear the symptoms such as papule and bubble in primary eczema, excite in eczema, it may appear that rotten to the corn and exudation symptom
Performance.General subacute eczema patient is that primary eczema and the mixing of secondary eczema occur mostly.
(2) exudative: the main foundation for diagnosing eczema is liquid that concurrent area skin will appear exudation, mostly chronic wet
The cutaneous manifestations of rash patient are relatively dry, and in the pathogenetic process of subacute eczema, have diffusate appearance.
(3) pruritic: obtaining eczema patients may feel that the itch of duration, serious itch allow many patients to be difficult to bear
By.When quieting down, this itch is felt can be more violent, if treated not in time, will lead to secondary
It aggravates, persistent state occurs.
(4) unresolved: eczema is easy recurrent exerbation, and symptom can be easy from a position delay to another portion
Position, the symptom of eczema are not easy to eliminate.Eczema can occur at any position of patient body.When suffering from acute eczema such as
Fruit is treated not in time, or correct method is taken to treat, it is easy to which causing eczema development is chronic eczema, is brought very to patient
Big ailing torment.
At present to the therapeutic agent of subacute eczema mainly based on steroids emulsifiable paste, curative effect is higher, but between subacute
Eczema " does not recover for a long time " this feature, and steroids cream drug is used for a long time and is possible to cause the side effect of atrophoderma, and more
The disadvantages of easy to recur afterwards.Therefore develop that a kind of drug effect can substitute Hormonic autacoid emulsifiable paste and Small side effects or drug without side-effects are for controlling
Treating skin subacute eczema has realistic meaning.
Summary of the invention
For overcome the deficiencies in the prior art with disadvantage, the primary purpose of the present invention is that provide it is a kind of treat it is subacute wet
The cream preparation of rash.
Another object of the present invention is to provide the preparation methods of the cream preparation of above-mentioned treatment subacute eczema.
The purpose of the invention is achieved by the following technical solution:
A kind of cream preparation for treating subacute eczema includes following component:
The starch is potato starch；
The nano zine oxide；
The emulsifiable paste matrix is water-soluble base；
The water-soluble base includes following component: 15wt% glycerol, water add to 100wt%；
The preparation method of the cream preparation of the treatment subacute eczema, comprises the following steps:
(1) by nano zine oxide, starch and emulsifiable paste matrix mix, 60-65 DEG C heating stirring 20-30 minutes, be cooled to room
Temperature obtains the matrix containing nano zine oxide；
(2) lanolin is added made from step (1) in mixture 1,45~55 DEG C heating stirring 10-25 minute, cool down
To 30-37 DEG C, mixture is obtained；
(3) shrubby sophora extract, garlic P.E and purslane extract are added in the mixture made from step (2), stirs
It mixes 10-15 minutes, then homogeneous, packing obtains the cream preparation of finished product treatment subacute eczema；
The revolving speed of stirring described in step (1), (2) and (3) is preferably 500-800rpm/min；
The condition of homogeneous described in step (3) is preferably 1000-1500rpm/min homogeneous 2-5min；
In the present invention, nano zine oxide has weak convergence, moist and protective effect to skin, and has sorption and functions/drying.
There is preferable transparency and retentiveness after potato starch gelatinization, both can be used as a part of matrix, it can also be with
Play good moisturizing, moisten effect；Meanwhile the potato starch after gelatinization to garlic P.E have certain stabilization, one
Determine to avoid the decomposition of the active principle allicin in garlic P.E in degree.
Lanolin can be such that the active component in cream preparation is absorbed by the skin rapidly, have adhesive force, property is stablized, and can inhale
Water is not easy rancid.
Shrubby sophora extract contains matrine (matrine), oxymatrine (oxymatrine), ammothamnine (sophor-
Anol), N-Methylcytisine (N-methylcytisine), Anagyrine (anagyrine), baptifoline (bap-
Iifoline), SopHocarpine (sophocarpine), d-isomatrine (d-isomatrine), Kuraridine (kurarid-
in).Remove first kurarinone (norkurarinone), Kuraridine alcohol (kuraridinol), kuh-seng alcohol (kurarinol), new kuh-seng
Alcohol (neo-kurarinol) removes first kuh-seng alcohol (norkurarinol), isokurarinone, separately contains formononetin
(formononetin) etc. components, have good relaxation effect to pruitus, can Bergamot Mint Extract, promote damaged blood vessels
The growth and reparation of nerve cell restore subcutaneous capillary cell viability, play the role of repairing well.
Garlic P.E main component is allicin (allyl sulfide) etc., has good fungistatic effect, can anti-inflammatory
Sterilization.
Purslane extract has contraction to vascular smooth muscle, skin caused by can soothing the skin and inhibiting because of drying
Skin itch can overcome garlic P.E to skin irritation, there is apparent anti-allergic effects.
The present invention has the following advantages and effects with respect to the prior art:
(1) the cream preparation component for the treatment of subacute eczema prepared by the present invention is simpler, has and soaks antipruritic, anti-inflammatory disappear
The effects of swollen, antiallergy.
(2) cream preparation for the treatment of subacute eczema prepared by the present invention includes active constituent nano zine oxide and a variety of
Active components of plants shrubby sophora extract, garlic P.E and purslane extract etc. can be controlled effectively by outer painting cream preparation
Subacute eczema is treated, there is certain therapeutic effect to acute eczema, chronic eczema and allergic dermatitis.
(3) the cream preparation preservative free for the treatment of subacute eczema prepared by the present invention, easy to use, safety.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
In embodiment, garlic P.E (contain allicin 2%) is purchased from Wuhan Ding Hui Chemical Co., Ltd., shrubby sophora extract and
Purslane extract is purchased from Xi'an Sai Bang Bioisystech Co., Ltd.
Embodiment 1
A kind of cream preparation for treating subacute eczema includes following component:
The preparation method of the cream preparation of the treatment subacute eczema, comprises the following steps:
(1) by nano zine oxide, potato starch and emulsifiable paste matrix, (include following component: 15wt% glycerol, water are added to
It 100wt%) mixes, 60-65 DEG C, 500-800rpm/min heating stirring 20-30 minutes are cooled to room temperature, and are obtained containing nano oxygen
Change the matrix of zinc；
(2) lanolin is added in mixture 1 made from step (1), 45~55 DEG C, 500-800rpm/min heating stirring
10-25 minutes, it is cooled to 30-37 DEG C, obtains mixture；
(3) shrubby sophora extract, garlic P.E and purslane extract are added in the mixture made from step (2),
500-800rpm/min is stirred 10-15 minutes, and then 1000-1500rpm/min homogeneous 2-5min, packing obtains finished product treatment
The cream preparation of subacute eczema.
Embodiment 2
A kind of cream preparation for treating subacute eczema includes following component:
The preparation method of the cream preparation of the treatment subacute eczema, comprises the following steps:
(1) by nano zine oxide, potato starch and emulsifiable paste matrix, (include following component: 15wt% glycerol, water are added to
It 100wt%) mixes, 60-65 DEG C, 500-800rpm/min heating stirring 20-30 minutes are cooled to room temperature, and are obtained containing nano oxygen
Change the matrix of zinc；
(2) lanolin is added in mixture 1 made from step (1), 45~55 DEG C, 500-800rpm/min heating stirring
10-25 minutes, it is cooled to 30-37 DEG C, obtains mixture；
(3) shrubby sophora extract, garlic P.E and purslane extract are added in the mixture made from step (2),
500-800rpm/min is stirred 10-15 minutes, and then 1000-1500rpm/min homogeneous 2-5min, packing obtains finished product treatment
The cream preparation of subacute eczema.
Embodiment 3
A kind of cream preparation for treating subacute eczema includes following component:
The preparation method of the cream preparation of the treatment subacute eczema, comprises the following steps:
(1) by nano zine oxide, potato starch and emulsifiable paste matrix, (include following component: 15wt% glycerol, water are added to
It 100wt%) mixes, 60-65 DEG C, 500-800rpm/min heating stirring 20-30 minutes are cooled to room temperature, and are obtained containing nano oxygen
Change the matrix of zinc；
(2) lanolin is added in mixture 1 made from step (1), 45~55 DEG C, 500-800rpm/min heating stirring
10-25 minutes, it is cooled to 30-37 DEG C, obtains mixture；
(3) shrubby sophora extract, garlic P.E and purslane extract are added in the mixture made from step (2),
500-800rpm/min is stirred 10-15 minutes, and then 1000-1500rpm/min homogeneous 2-5min, packing obtains finished product treatment
The cream preparation of subacute eczema.
Effect example
Diagnostic criteria: traditional Chinese medicine industry standard " the Chinese medical disease diagnosis promulgated referring to State Administration of Traditional Chinese Medicine's nineteen ninety-five
Criterion of therapeutical effect " related content formulates: it 1. can be developed by acute eczema or the subacute breaking-out of chronic eczema；2. skin lesion is with papule, knot
Based on scab, the scales of skin that peel off, it is seen that a small amount of exudation is rotten to the corn, can send out in any position of body；3. acute pruritus.
Choosing clinical symptoms is to meet subacute eczema diagnostic criteria；Age 18~70 years old, at the skin lesion outside wipe embodiment 1
The cream preparation of~3 treatment subacute eczemas obtained, is subject to and affected part is completely covered.It is each daily morning and evening to apply 1 time, continuously apply 5
It.
It the results are shown in Table 1, as it can be seen from table 1 the cream preparation for the treatment of subacute eczema produced by the present invention is for sub- anxious
Property eczema there is preferable therapeutic effect, wherein the therapeutic effect of the emulsifiable paste of the treatment subacute eczema obtained of embodiment 1 is most
It is good.
The emulsifiable paste effect assessment of 1 Examples 1 to 3 of table treatment subacute eczema obtained
| Group | Experiment number | It is effective | Effectively | In vain | Total effective rate |
| Embodiment 1 | 40 | 28 | 9 | 3 | 92.5% |
| Embodiment 2 | 40 | 25 | 10 | 5 | 87.5% |
| Embodiment 3 | 40 | 25 | 11 | 4 | 90% |
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (8)
1. a kind of cream preparation for treating subacute eczema, it is characterised in that include following component:
2. the cream preparation for the treatment of subacute eczema according to claim 1, it is characterised in that:
The starch is potato starch.
3. the cream preparation for the treatment of subacute eczema according to claim 1, it is characterised in that:
The nano zine oxide.
4. the cream preparation for the treatment of subacute eczema according to claim 1, it is characterised in that:
The emulsifiable paste matrix is water-soluble base.
5. the cream preparation for the treatment of subacute eczema according to claim 1, it is characterised in that:
The water-soluble base includes following component: 15wt% glycerol, water add to 100wt%.
6. the preparation method of the cream preparation of the described in any item treatment subacute eczemas of claim 1~6, it is characterised in that packet
Containing following steps:
(1) by nano zine oxide, starch and emulsifiable paste matrix mix, 60-65 DEG C heating stirring 20-30 minutes, be cooled to room temperature, obtain
To the matrix containing nano zine oxide；
(2) lanolin is added made from step (1) in mixture 1,45~55 DEG C heating stirring 10-25 minutes, be cooled to 30-
37 DEG C, obtain mixture；
(3) shrubby sophora extract, garlic P.E and purslane extract are added in the mixture made from step (2), stirs 10-
15 minutes, then homogeneous, packing obtained the cream preparation of finished product treatment subacute eczema.
7. the preparation method of the cream preparation for the treatment of subacute eczema according to claim 6, it is characterised in that:
The revolving speed of stirring described in step (1), (2) and (3) is preferably 500-800rpm/min.
8. the preparation method of the cream preparation for the treatment of subacute eczema according to claim 6, it is characterised in that:
The condition of homogeneous described in step (3) is preferably 1000-1500rpm/min homogeneous 2-5min.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910513599.1A CN110200901A (en) | 2019-06-14 | 2019-06-14 | A kind of cream preparation that treating subacute eczema and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910513599.1A CN110200901A (en) | 2019-06-14 | 2019-06-14 | A kind of cream preparation that treating subacute eczema and preparation method |
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| CN110200901A true CN110200901A (en) | 2019-09-06 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530462A (en) * | 2009-04-27 | 2009-09-16 | 郭青云 | Composition for treating eczema and preparation method thereof |
| CN102526300A (en) * | 2011-12-29 | 2012-07-04 | 高国华 | Skin-comforting emulsifiable paste and preparation method |
| CN102614263A (en) * | 2012-04-18 | 2012-08-01 | 刘宁 | Externally-applied medicament for treating acute eczema |
| CN105031254A (en) * | 2015-07-07 | 2015-11-11 | 王睿超 | Ointment used for treating dermatitis and preparation method thereof |
| CN107496498A (en) * | 2017-08-30 | 2017-12-22 | 浙江天多好环保科技有限公司 | It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema |
| CN107823302A (en) * | 2017-12-01 | 2018-03-23 | 班戈设备系统（苏州）有限公司 | It is a kind of to be used to treat ointment of eczema and preparation method thereof |
-
2019
- 2019-06-14 CN CN201910513599.1A patent/CN110200901A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530462A (en) * | 2009-04-27 | 2009-09-16 | 郭青云 | Composition for treating eczema and preparation method thereof |
| CN102526300A (en) * | 2011-12-29 | 2012-07-04 | 高国华 | Skin-comforting emulsifiable paste and preparation method |
| CN102614263A (en) * | 2012-04-18 | 2012-08-01 | 刘宁 | Externally-applied medicament for treating acute eczema |
| CN105031254A (en) * | 2015-07-07 | 2015-11-11 | 王睿超 | Ointment used for treating dermatitis and preparation method thereof |
| CN107496498A (en) * | 2017-08-30 | 2017-12-22 | 浙江天多好环保科技有限公司 | It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema |
| CN107823302A (en) * | 2017-12-01 | 2018-03-23 | 班戈设备系统（苏州）有限公司 | It is a kind of to be used to treat ointment of eczema and preparation method thereof |
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Application publication date: 20190906 |