CN107496498A - It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema - Google Patents

It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema Download PDF

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Publication number
CN107496498A
CN107496498A CN201710764534.5A CN201710764534A CN107496498A CN 107496498 A CN107496498 A CN 107496498A CN 201710764534 A CN201710764534 A CN 201710764534A CN 107496498 A CN107496498 A CN 107496498A
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extract
preparation
eczema
filtrate
emulsifiable paste
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韩建文
吴勇
杨智浩
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Zhejiang Tian Da Hao Environmental Protection Technology Co Ltd
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Zhejiang Tian Da Hao Environmental Protection Technology Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses it is a kind of treat sensitive skin, eczema emulsifiable paste and preparation method thereof, including following components and the mass percent of each component be：Camomile extract 1 10%, purslane extract 1 10%, Radix et Caulis Opuntiae Dillenii extract 1 10%, Honegsukle flower P.E 1 10%, Flos Chrysanthemi Indici extract 1 10%, common cnidium fruit P.E 1 10%, licorice 1 10%, shrubby sophora extract 1 10%, shea butter 5 15%, cetostearyl alcohol 1 5%, glycerine 1 10%, propane diols 1 5%, vaseline 1 5%, Dormant oils 1 10%, dimethyl silicone polymer 1 5%, Triclosan 0.1 0.5%, glycerin monostearate 1 5%, the stearates 1 5% of PEG 100, menthol 0.1 1%, methyl hydroxybenzoate 0.05 0.2%, Nipasol 0.05 0.2%, purified water 30 70%.The present invention is applied to the sensitive of infant skin or adult, has quick, Small side effects, the features such as being not easy recurrent exerbation.

Description

It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema
【Technical field】
It is particularly a kind of to treat sensitive skin, the emulsifiable paste of eczema and its preparation side the present invention relates to field of Chinese medicinal composition Method.
【Background technology】
Eczema is a kind of common epidermis as caused by a variety of internal and external factors and the inflammatory dermatoses of high dermis, skin lesion There is symmetry, exudative, pruritic and easy recurrent exerbation, clinical manifestation is divided into acute, subacute and chronic three phase, More based on erythema, papule, papulo-vesicle, fash center is obvious, is gradually scattered to surrounding, indefinite border, diffusivity, has to ooze out and incline To.
Eczema is mainly in the children within 5 years old, it is especially one-year-old within baby easily break out, be also found in adult.Baby Youngster's eczema, is referred to as that tire leprosy, infantile eczema, tire wind, tire are red etc., and infantile eczema is paediatrics common disease frequently-occurring disease on traditional Chinese medical science ancient literature One of.With local erythema, papule, blister, there is juice to ooze out, rotten to the corn, itch and recurrent exerbation are its main feature.This disease The origin cause of formation by the pungent scorching thing of wet nurse's overfeeding, by the transmission of breast milk, causes baby by damp and hot tired, transformation failure of spleen more.More simultaneous baby For the body of young sun, deiciency of primordial QI, damp and hot heresy is attacked in space between skin and muscles, then inside and outside damp and hot phase is fought knot, i.e. cost disease.If damp and hot and ailment said due to cold or exposure Mutually and, then benefaction number becomes, and itch is obvious, rises one after another；If damp and hotization is fiery, rising body fluid, then the flowing water that festers, affected part are shown as again Skin and flesh is scarlet.
At present, the medicine for treating eczema mainly selects appropriate dosage forms and medicine according to skin lesion situation, as tacrolimus is soft Cream, pimecrolimus ointment, emulsion of hydrocortisone butyrate etc., these emulsifiable pastes exist curative effect unobvious, easily recurrence, hormonal it is strong, The deficiencies of side effect is big.Easily sensitive but baby has a low resistance, born a pretty, delicate skin, eczema ointment on the market can seldom be used for baby Youngster or it is applicable the effect of bad or recurrent exerbation or side effect it is big, cause the time of illness to drag very long, the baby with eczema The frequent recurrent exerbation within 6 months, cause the scratchiness of baby, lose the appetite and sleep the problems such as bad.
【The content of the invention】
The purpose of the present invention is exactly to solve the problems of the prior art, and proposition is a kind of to treat sensitive skin, the emulsifiable paste of eczema And preparation method thereof, suitable for infant skin or the sensitive of adult, there are quick, Small side effects, be not easy to send out repeatedly The features such as making.
To achieve the above object, the present invention, which proposes, a kind of treats sensitive skin, the emulsifiable paste and preparation method thereof of eczema, bag The mass percent for including following components and each component is：Camomile extract 1-10%, purslane extract 1-10%, cactus Extract 1-10%, Honegsukle flower P.E 1-10%, Flos Chrysanthemi Indici extract 1-10%, common cnidium fruit P.E 1-10%, radix glycyrrhizae carry Take thing 1-10%, shrubby sophora extract 1-10%, shea butter 5-15%, cetostearyl alcohol 1-5%, glycerine 1-10%, propane diols 1-5%, vaseline 1-5%, Dormant oils 1-10%, dimethyl silicone polymer 1-5%, Triclosan 0.1-0.5%, single tristearin Acid glyceride 1-5%, PEG-100 stearate 1-5%, menthol 0.1-1%, methyl hydroxybenzoate 0.05-0.2%, Nipasol 0.05-0.2%, purified water 30-70%.
Preferably, the preparation method of described camomile extract is as follows：
A) take 40-50 part chamomiles to clean up, crush, obtained chamomile powder is 50- with the concentration of 50-60 parts 60% ethanol water soaks, soak time 30-60min, and coarse filtration is stand-by after standing；
B) and then filtrate is placed under 0.8 standard atmospheric pressure, 85-95 DEG C of environment and distilled, removing slips out thing, collects remaining Filtrate；
C) 40-50 part propane diols is added in filtrate to be uniformly mixed, filtered through stainless steel plate filter, collect filter Liquid is standby.
Preferably, the preparation method of described purslane extract is as follows：
A) take 10-20 part purslane soaking and washings clean, addition 80-90 parts concentration is 75% alcohol, at 50-60 DEG C
The lower extraction for carrying out purslane, extraction time is 1-2 hours, by the purslane coarse filtration after extraction, is decolourized；
B) and then by filtrate distilled at 0.8 standard atmospheric pressure, 45-60 DEG C；
C) treat that filtrate is concentrated to the 10-20% of material liquid, add the butanediol of equivalent 1.3 and be well mixed, through stainless steel sheet frame Filter filters, and it is standby to collect filtrate.
Preferably, the preparation method of described Radix et Caulis Opuntiae Dillenii extract is as follows：
A) take 30-40 part cactuses to clean up, crush, obtained cactus powder and the deionized water one of 60-70 parts Rise and add in enzymatic vessel, be passed through steam heat to 100 DEG C, be incubated 30min, steam off, open cooling water valve and injected into chuck Cooling water, pot liquid temperature is closed cooling water when being cooled to 50 DEG C, continue to stir equilibrium temperature, when temperature reaches 45 DEG C When, add enzyme preparation and digested；
B) enzymolysis terminates, and is heated to 100 DEG C or so steam offs, stirs lower enzyme deactivation 15~20 minutes or so；
C) the feed liquid material after enzymolysis is gone out, filtered out larger impurity with bag type filter, filtrate is placed on freezer freezing 24 hours, coarse filtration, then through stainless steel plate filter refined filtration, it is standby to collect filtrate.
Preferably, the Honegsukle flower P.E, Flos Chrysanthemi Indici extract, common cnidium fruit P.E, licorice, kuh-seng carry Take the preparation method of thing as follows：
A) medicinal material is cleaned up, by 1：3-10 ratios add deionized water soak at room temperature；
B) three times, coarse filtration is decolourized for low temperature extraction；
C) filtrate is placed on into freezer to freeze 24 hours, through stainless steel plate filter refined filtration, it is standby collects filtrate.
Preferably, specific preparation process is:
A) take shea butter, cetostearyl alcohol, vaseline, Dormant oils, dimethyl silicone polymer, Triclosan, list hard Glycerol, PEG-100 stearates, Nipasol are mixed and heated to 75-80 DEG C；
B) chamomile, cactus, glycerine, propane diols, methyl hydroxybenzoate, purified water is taken to be mixed and heated to 75-80 DEG C；
C) oil phase is pumped into aqueous phase, be well mixed, homogeneous, cooling；
D) less than 50 DEG C are cooled to, adds purslane, honeysuckle, chrysanthemum indicum, frutus cnidii, radix glycyrrhizae, kuh-seng, menthol；
E) it is cooled to room temperature.
Preferably, the mass percent including following components and each component is：Camomile extract 5%, purslane carry Take thing 5%, Radix et Caulis Opuntiae Dillenii extract 5%, Honegsukle flower P.E 3%, Flos Chrysanthemi Indici extract 2%, common cnidium fruit P.E 2%, radix glycyrrhizae Extract 2%, shrubby sophora extract 3%, shea butter 8%, cetostearyl alcohol 4%, glycerine 4%, propane diols 2%, vaseline 4%, Dormant oils 4%, dimethyl silicone polymer 1%, Triclosan 0.2%, glycerin monostearate 2.5%, PEG-100 are stearic Acid esters 2.5%, menthol 0.5%, methyl hydroxybenzoate 0.2%, Nipasol 0.1%, purified water 40%.
Beneficial effects of the present invention：The present invention is by using chamomile, purslane, cactus, honeysuckle, chrysanthemum indicum, snake The Chinese medical extracts such as machine tool, radix glycyrrhizae and kuh-seng are raw material, have the effects such as clearing heat and detoxicating, pain of alleviation, refrigerant hemostasis, are applied to Infant skin or the sensitive of adult, there are quick, Small side effects, the features such as being not easy recurrent exerbation.
【Embodiment】
The present invention is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema, including following components and each component Mass percent is：Camomile extract 1-10%, purslane extract 1-10%, Radix et Caulis Opuntiae Dillenii extract 1-10%, honeysuckle Extract 1-10%, Flos Chrysanthemi Indici extract 1-10%, common cnidium fruit P.E 1-10%, licorice 1-10%, kuh-seng extraction Thing 1-10%, shea butter 5-15%, cetostearyl alcohol 1-5%, glycerine 1-10%, propane diols 1-5%, vaseline 1-5%, Dormant oils 1-10%, dimethyl silicone polymer 1-5%, Triclosan 0.1-0.5%, glycerin monostearate 1-5%, PEG- 100 stearate 1-5%, menthol 0.1-1%, methyl hydroxybenzoate 0.05-0.2%, Nipasol 0.05-0.2%, purified water 30-70%.
Embodiment：It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema, including following components and each component Mass percent is：
Camomile extract 5%, purslane extract 5%, Radix et Caulis Opuntiae Dillenii extract 5%, Honegsukle flower P.E 3%, mother chrysanthemum Flower extract 2%, common cnidium fruit P.E 2%, licorice 2%, shrubby sophora extract 3%, shea butter 8%, cetearyl alcohol Alcohol 4%, glycerine 4%, propane diols 2%, vaseline 4%, Dormant oils 4%, dimethyl silicone polymer 1%, Triclosan 0.2%th, glycerin monostearate 2.5%, PEG-100 stearates 2.5%, menthol 0.5%, methyl hydroxybenzoate 0.2%, oxybenzene Propyl ester 0.1%, purified water 40%.
Described specific preparation method is as follows：
A) take shea butter, cetostearyl alcohol, vaseline, Dormant oils, dimethyl silicone polymer, Triclosan, list hard Glycerol, PEG-100 stearates, Nipasol are mixed and heated to 75-80 DEG C；
B) chamomile, cactus, glycerine, propane diols, methyl hydroxybenzoate, purified water is taken to be mixed and heated to 75-80 DEG C；
C) oil phase is pumped into aqueous phase, be well mixed, homogeneous, cooling；
D) less than 50 DEG C are cooled to, adds purslane, honeysuckle, chrysanthemum indicum, frutus cnidii, radix glycyrrhizae, kuh-seng, menthol；
E) it is cooled to room temperature.
Above-described embodiment is the description of the invention, is not limitation of the invention, it is any to simple transformation of the present invention after Scheme belong to protection scope of the present invention.

Claims (7)

1. a kind of treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema, it is characterised in that：Including following components and each component Mass percent be：Camomile extract 1-10%, purslane extract 1-10%, Radix et Caulis Opuntiae Dillenii extract 1-10%, gold and silver Flower extract 1-10%, Flos Chrysanthemi Indici extract 1-10%, common cnidium fruit P.E 1-10%, licorice 1-10%, kuh-seng carry Take thing 1-10%, shea butter 5-15%, cetostearyl alcohol 1-5%, glycerine 1-10%, propane diols 1-5%, vaseline 1-5%, ore deposit Oily 1-10%, dimethyl silicone polymer 1-5%, Triclosan 0.1-0.5%, glycerin monostearate 1-5%, PEG- 100 stearate 1-5%, menthol 0.1-1%, methyl hydroxybenzoate 0.05-0.2%, Nipasol 0.05-0.2%, purified water 30-70%.
2. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that：Institute The preparation method for the camomile extract stated is as follows：
A) take 40-50 part chamomiles to clean up, crush, obtained chamomile powder is 50-60%'s with the concentration of 50-60 parts Ethanol water soaks, soak time 30-60min, and coarse filtration is stand-by after standing；
B) and then filtrate is placed under 0.8 standard atmospheric pressure, 85-95 DEG C of environment and distilled, removing slips out thing, collects remaining filter Liquid；
C) 40-50 part propane diols being added in filtrate to be uniformly mixed, being filtered through stainless steel plate filter, it is standby to collect filtrate With.
3. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that：Institute The preparation method for the purslane extract stated is as follows：
A) take 10-20 part purslane soaking and washings clean, addition 80-90 parts concentration is 75% alcohol, at 50-60 DEG C
The lower extraction for carrying out purslane, extraction time is 1-2 hours, by the purslane coarse filtration after extraction, is decolourized；
B) and then by filtrate distilled at 0.8 standard atmospheric pressure, 45-60 DEG C；
C) treat that filtrate is concentrated to the 10-20% of material liquid, add the butanediol of equivalent 1.3 and be well mixed, through stainless steel plate-frame filtering Device filters, and it is standby to collect filtrate.
4. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that：Institute The preparation method of the Radix et Caulis Opuntiae Dillenii extract stated is as follows：
A) take 30-40 part cactuses to clean up, crush, obtained cactus powder adds together with the deionized water of 60-70 parts Enter in enzymatic vessel, be passed through steam heat to 100 DEG C, be incubated 30min, steam off, open cooling water valve and cooling is injected into chuck Water, pot liquid temperature is closed cooling water when being cooled to 50 DEG C, continue to stir equilibrium temperature, when temperature reaches 45 DEG C, add Enter enzyme preparation to be digested；
B) enzymolysis terminates, and is heated to 100 DEG C or so steam offs, stirs lower enzyme deactivation 15~20 minutes or so；
C) the feed liquid material after enzymolysis is gone out, filtered out larger impurity with bag type filter, it is small that filtrate is placed on freezer freezing 24 When, coarse filtration, then through stainless steel plate filter refined filtration, it is standby to collect filtrate.
5. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that：Institute The Honegsukle flower P.E stated, Flos Chrysanthemi Indici extract, common cnidium fruit P.E, licorice, shrubby sophora extract preparation method such as Under：
A) medicinal material is cleaned up, by 1：3-10 ratios add deionized water soak at room temperature；
B) three times, coarse filtration is decolourized for low temperature extraction；
C) filtrate is placed on into freezer to freeze 24 hours, through stainless steel plate filter refined filtration, it is standby collects filtrate.
6. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that tool The preparation process of body is:
A) shea butter, cetostearyl alcohol, vaseline, Dormant oils, dimethyl silicone polymer, Triclosan, monostearate are taken Glyceride, PEG-100 stearates, Nipasol are mixed and heated to 75-80 DEG C；
B) chamomile, cactus, glycerine, propane diols, methyl hydroxybenzoate, purified water is taken to be mixed and heated to 75-80 DEG C；
C) oil phase is pumped into aqueous phase, be well mixed, homogeneous, cooling；
D) less than 50 DEG C are cooled to, adds purslane, honeysuckle, chrysanthemum indicum, frutus cnidii, radix glycyrrhizae, kuh-seng, menthol；
E) it is cooled to room temperature.
7. a kind of sensitive skin, the emulsifiable paste and preparation method thereof of eczema are treated as claimed in claim 1, it is characterised in that：Bag The mass percent for including following components and each component is：Camomile extract 5%, purslane extract 5%, Radix et Caulis Opuntiae Dillenii extract 5%th, Honegsukle flower P.E 3%, Flos Chrysanthemi Indici extract 2%, common cnidium fruit P.E 2%, licorice 2%, shrubby sophora extract 3%th, shea butter 8%, cetostearyl alcohol 4%, glycerine 4%, propane diols 2%, vaseline 4%, Dormant oils 4%, polydimethylsiloxanes Alkane 1%, Triclosan 0.2%, glycerin monostearate 2.5%, PEG-100 stearates 2.5%, menthol 0.5%th, methyl hydroxybenzoate 0.2%, Nipasol 0.1%, purified water 40%.
CN201710764534.5A 2017-08-30 2017-08-30 It is a kind of to treat sensitive skin, the emulsifiable paste and preparation method thereof of eczema Pending CN107496498A (en)

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CN109568182A (en) * 2018-12-14 2019-04-05 江西绿海油脂有限公司 A kind of tea oil children Shu Run cream
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CN115770267A (en) * 2021-09-07 2023-03-10 广州赞誉化妆品有限公司 Infantile eczema ointment and preparation method thereof
CN113968774A (en) * 2021-11-23 2022-01-25 辽宁中医药大学 Polyaryl compound in purslane and extraction and separation method thereof
CN113968774B (en) * 2021-11-23 2024-01-30 辽宁中医药大学 Polyarylate in purslane and extraction and separation method thereof

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