KR102659309B1 - Cosmetic composition for improvement of skin itching by dry skin or atopic dermatitis - Google Patents

Abstract

The present invention blocks, removes or emulsifies various factors that cause skin itching in a complex and stepwise manner, such as dryness, inflammation, sensitivity, atopic dermatitis, skin pH imbalance through cleaning, and skin microbial imbalance, and keeps damaged skin healthy. It relates to a cosmetic composition that can fundamentally solve skin itchiness by restoring skin. In particular, it relates to a cosmetic composition specialized for relieving skin itchiness caused by atopic dermatitis and dryness. Damask rose flower water, Bogum cactus seed oil, and natural trehalose are effective. Included as an ingredient.

Description

Cosmetic composition for alleviating skin itching caused by atopic dermatitis and dryness {COSMETIC COMPOSITION FOR IMPROVEMENT OF SKIN ITCHING BY DRY SKIN OR ATOPIC DERMATITIS}

The present invention relates to a cosmetic composition for alleviating skin itching, and in particular to a cosmetic composition specialized for alleviating skin itching caused by atopic dermatitis and dryness, among various factors that cause skin itching.

Itching refers to a condition of the skin that causes an unpleasant feeling of wanting to scratch, and is caused by various factors such as dryness, inflammation, sensitivity, atopic dermatitis, skin pH imbalance due to cleansing, and skin microbial imbalance.

Most of the conventional cosmetics for relieving skin itching are aimed at temporarily relieving symptoms rather than fundamentally solving the factors described above, such as blocking or removing the causative factors that cause itching.

As an example, the prior art document, Republic of Korea Patent Publication No. 10-2007-0095588, contains Houttuynia cordata, angelica root, mugwort, Cheongung, Sinseoncho, Chinese sycamore, pine sprout, mint, mung bean, apricot seed, resin, Sanghwang mushroom, honeysuckle, ginger, We are disclosing a natural herbal composition for the treatment of atopic skin disease containing extracts obtained from natural herbal plants such as ginseng, ginseng, green tea, marigold, bellflower root, and black bean. These herbal medicines have functions such as dermatitis-related physiological activity. It has been frequently used in cosmetics for this purpose, but the effect appears within a short period of time and is minimal, and since it has mostly been used for temporary relief, there is a limit to curing the fundamental cause.

Republic of Korea Patent Publication No. 10-2007-0095588

The present invention was conceived to solve the above-mentioned problems, and it complexly and step-by-step blocks various factors that cause skin itching, such as dryness, inflammation, sensitivity, atopic dermatitis, skin pH imbalance due to washing, and skin microbial imbalance. The purpose is to provide a cosmetic composition that can fundamentally solve skin itching by removing or emulsifying and restoring damaged skin to health, and in particular, a cosmetic composition specialized for alleviating skin itching caused by atopic dermatitis and dryness. The purpose is to provide

The technical problems of the present invention are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly understood by those skilled in the art from the description below.

The present invention relates to a cosmetic composition for alleviating skin itchiness caused by atopic dermatitis and dryness, and includes rose damask water, prickly pear seed oil, and natural trehalose as active ingredients.

In addition, it is characterized by further containing millet seed extract as an active ingredient, which supplies beneficial microorganisms to the skin and neutralizes alkalized skin pH.

In addition, it is characterized by further containing shield mushroom extract as an active ingredient, which plays a role in blocking the activation of TRPV1, a major mediator of itching.

In addition, it is characterized in that it further contains one or more ingredients selected from blackcurrant seed oil, balloon vine flower/leaf/vine extract, unsaponifiable sunflower seed oil, blue tansy flower oil, and triethyl citrate as an active ingredient.

The cosmetic composition of the present invention is characterized in that it is a mist type that can be sprayed by spraying.

According to the present invention as described above, the cosmetic composition according to the present invention reduces skin itching by moisturizing the skin, relieving inflammation, blocking the activation of TRPV1 (Transient receptor potential vanilloid 1), a major mediator of itching, neutralizing skin pH, and restoring beneficial skin microorganisms. Skin itching can be fundamentally solved by complexly and step by step blocking, removing or emulsifying the various triggering factors and restoring damaged skin to health.

In particular, it contains three active ingredients that are excellent for strengthening and maintaining skin moisturization, making it very effective in alleviating skin itchiness caused by dryness among the various factors that cause skin itching.

Furthermore, it has the effect of strengthening the skin barrier, soothing the skin, protecting the skin, providing a cooling sensation, removing odor caused by pus, providing a pleasant scent, and preventing skin damage due to antioxidant and antibacterial properties.

In addition, since all ingredients are based on natural ingredients or organic substances, it is suitable for use on all skin types such as oily skin, normal skin, dry skin, and combination skin, and can also be used directly on sensitive skin, atopic skin, and acne-prone skin. It has the characteristics of being hypoallergenic and non-toxic.

The effects of the present invention are not limited to those mentioned above, and may be clearly understood by those skilled in the art from the description throughout the specification, but also include other effects that are not explicitly mentioned.

Figure 1 is a result graph showing the measurement results of skin moisturization improvement.
Figure 2 is a result graph showing the results of measuring the effect of maintaining skin moisturization for 24 hours.
Figure 3 shows the results of images taken before use, after one use, and after four weeks of use for one of the study subjects, among the results of measuring the effect of lasting skin moisturization for 24 hours.
Figure 4 is a graph of skin moisture content among the evaluation results for temporary relief of itchiness caused by skin dryness.
Figure 5 is a graph showing the results of skin moisture loss among the evaluation results for temporary relief of itching caused by skin dryness.
Figure 6 is a graph showing the results of the VAS evaluation index for itching due to dryness among the evaluation results for temporary relief of itching due to skin dryness.
Figure 7 shows the results of an evaluation of temporary relief from itchiness caused by skin dryness, showing images taken before and after 4 weeks of use for one of the study subjects.
Figure 8 is a graph showing the results of the evaluation of suitability for use on acne-prone skin and the number of papules.
Figure 9 is a graph showing the results of the evaluation of suitability for use on acne-prone skin and the number of nodules.
Figure 10 shows the results of the evaluation of suitability for use on acne-prone skin, images taken before and after 4 weeks of use for one of the study subjects.
Figure 11 is a graph of the results for the KAGS grade among the evaluation results for suitability for use on acne-prone skin.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the attached drawings. The advantages and features of the present invention and methods for achieving them will become clear by referring to the embodiments described in detail below along with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various different forms, and the present embodiments are merely intended to ensure that the disclosure of the present invention is complete and to provide common knowledge in the technical field to which the present invention pertains. It is provided to fully inform those who have the scope of the invention, and the present invention is only defined by the scope of the claims. Like reference numerals refer to like elements throughout the specification.

Unless otherwise defined, all terms (including technical and scientific terms) used in this specification may be used with meanings that can be commonly understood by those skilled in the art to which the present invention pertains. Additionally, terms defined in commonly used dictionaries are not interpreted ideally or excessively unless clearly specifically defined. The terms used in this specification are for describing embodiments and are not intended to limit the invention. As used herein, singular forms also include plural forms, unless specifically stated otherwise in the context.

As used in the specification, “comprises” and/or “comprising” refers to the presence of one or more other components, steps, operations and/or elements. or does not rule out addition.

In this specification, the term "cosmetic" refers to an article used in a similar manner, such as applying, rubbing, or spraying, to clean or beautify the human body. For example, skin care cosmetics such as lotion, emulsion, essence, cream, cleansing, pack, oil liquid, massage agent, detergent, deodorant, hand cream, lip cream, makeup base, foundation, blush, eye shadow, mascara , makeup cosmetics such as eyeliner, eyebrows, and lipstick, hair cosmetics such as shampoo, conditioner, treatment, and setting agent, and UV-blocking cosmetics such as sunscreen.

As used herein, the term "active ingredient" refers to an ingredient of a cosmetic composition that provides effects such as prevention, protection, improvement, supplementation, relief, or treatment when applied to the skin.

In this specification, the term "extract" means extracted through a known extraction method, using a conventional extraction solvent under conventional conditions of temperature and pressure, according to a conventional extraction method known in the art. Includes all manufactured products. For example, hot water extraction method, heat extraction method, reflux cooling extraction method, ultrasonic extraction method, supercritical extraction method using carbon dioxide, cold compression method, extraction method using an ultrafiltration membrane with a certain molecular weight cut-off value, extraction method using various chromatography methods, etc. Conventional extraction methods known in the art may be used. Furthermore, fermented products or fermented extracts extracted by fermentation using enzymes, yeast, or lactic acid bacteria may also be included.

Hereinafter, the present invention will be described.

The cosmetic composition for relieving skin itching of the present invention contains rose damask water, prickly pear seed oil, and natural trehalose as essential active ingredients.

Rosa Damascena Flower Water is an aqueous solution obtained by steam distillation of damask rose flowers. It acts as a natural moisturizer to revitalize the skin, soothe the skin, and provide a cooling sensation to relieve itching. Do it. In addition, it has sterilizing, antibacterial, and antioxidant effects, so it helps patients suffering from itching and atopy to heal wounds caused by frequent scratching of the affected area quickly and keeps the affected area clean. In addition, it has the pleasant scent of roses, which covers the unpleasant odor caused by pus in the affected area and has the effect of uplifting the mood. Damask rose flower water may be included in an amount of 50 to 80% by weight based on the total weight of the cosmetic composition.

Opuntia Ficus-Indica Seed Oil is an oil obtained by pressing the seeds of the Opuntia Ficus-Indica Seed Oil, which provides sufficient moisture to dry skin. It also contains various types of fatty acids, phenols, vitamin E, and phytosterols, so it has the effect of improving the health of various skin types, regardless of skin type. It also contains antioxidant and antibacterial ingredients to prevent skin damage caused by sunlight and other stress factors, and has the effect of purifying the skin and preventing acne breakouts. Furthermore, it contains a high content of linoleic acid, which strengthens the skin's moisture retention properties and helps maintain moisture. Bogeum cactus seed oil may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

Natural trehalose is a naturally occurring polysaccharide that appears widely in plants and animals. It has excellent moisturizing properties, preventing skin moisture loss and protecting cells by combining with moisture. It also helps maintain the natural structure of the skin, protects skin fibroblasts from drying by replacing moisture in tissues, and as an effective moisturizer for the skin, it reduces skin damage from dryness, heat, and cold. It is also composed of two glycose molecules, which are non-reducing sugars and have stable properties even under extreme pH and temperature conditions. Furthermore, they prevent the formation of volatile aldehydes caused by fatty acid decomposition, thereby suppressing body odor in patients suffering from itching and atopy. It also has an effect. Natural trehalose may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

In this way, the cosmetic composition of the present invention simultaneously contains damask rose flower water, Bogeum cactus seed oil, and natural trehalose, which are excellent for strengthening and maintaining skin moisturization, as essential active ingredients, thereby eliminating various factors that cause skin itching, especially dryness. It is very effective in relieving skin itchiness caused by

The cosmetic composition for alleviating skin itching of the present invention may further include millet seed extract as an active ingredient.

Specifically, Panicum Miliaceum Seed Extract is an extract obtained by fermenting the seeds of millet, a gluten-free grain, using lactic acid bacteria. Through this process, minerals beneficial to the skin are produced and it is effective in improving the skin microbial environment. Contains thix fermentation products. These fermentation products have the effect of suppressing inflammation of the skin. In addition, the fermentation product contained in millet seed extract has a pH of about 4.0 to 5.5, and plays a role in neutralizing the pH of the skin, which has become unbalanced due to the use of alkaline (about pH 8 to 10) cleansers, to pH 5.5 to 5.9. Furthermore, when using alkaline cleansers, microorganisms beneficial to the skin are also destroyed, but millet seed extract has the effect of instantly supplying beneficial microorganisms to the skin. The microorganisms supplied in this way play a role in defending against skin invaders, such as bacteria. Certain bacteria secrete toxins to activate inflammatory factors, kill attacked cells, and decompose skin proteins. In this process, a strong inflammatory response occurs in the skin, the skin barrier collapses, and this process becomes chronic, causing atopic dermatitis. , As a result, skin keratinization occurs and the skin crust thickens, which causes dryness and itching. Therefore, various beneficial microorganisms must exist in balance on the skin, and millet seed extract helps restore microorganisms destroyed by the use of cleansers. Millet seed extract may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

In addition, the cosmetic composition for alleviating skin itching of the present invention may further include shield mushroom extract as an active ingredient.

Specifically, shield mushroom extract is extracted from shield mushrooms, including bunch shield mushroom (Albatrellus confluens), wool shield mushroom (Albatrellus ovinus), flower shield mushroom (Albatrellus dispansus), green shield mushroom (Albatrellus caeruleoporus), and gray shield mushroom (Albatrellus yasudae). It may be an extract extracted from one or more types of mushrooms selected from Pouzar) and Albatrellus pes-caprae. More specifically, it is preferable that it is an extract extracted from bunch shield mushroom or woolly shield mushroom, which has a more excellent TRPV1 activation blocking effect than other shield mushrooms, and the ratio of the bunch shield mushroom extract and woolly shield mushroom extract is 1:1 to 2:1. It is also preferable to use a mixture by weight. This shield mushroom extract contains strong antioxidants, gripolin and novel neogrifolin, and blocks the activation of TRPV1, a major mediator of itching, thereby providing an analgesic effect on itching, a type of pain sensation. have Shield mushroom extract may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

In addition, the cosmetic composition for relieving skin itching of the present invention contains one or more selected from blackcurrant seed oil, balloon vine flower/leaf/vine extract, unsaponifiable sunflower seed oil, shield mushroom extract, blue tanji flower oil, and triethyl citrate. Additional ingredients may be included as active ingredients.

Specifically, black currant seed oil is an oil extracted from blackcurrant seeds. It is rich in omega 3 and omega 6 and has the effect of strengthening the skin barrier and soothing inflammation. It is especially rich in linoleic acid and gamma linolenic acid, which are types of omega 3 or omega 6 fatty acids. Linoleic acid plays an important role in the production of ceramide 1, helping to form the skin barrier, and gamma-linolenic acid has the effect of producing anti-inflammatory prostaglandin (an element that is deficient in the skin of atopic dermatitis patients). It also contains stearidonic acid, which prevents the production of inflammatory mediators, making it effective in soothing inflammation. Blackcurrant seed oil may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

Cardiospermum Halicacabum Flower/Leaf/Vine Extract is extracted from the flowers, leaves, and vines of balloon vine. Phytosterols, commonly known as plant-derived steroids, are compounds of the plant-derived polyphenol series. It is rich in flavonoids, saponin, and tannin acid, so it has an anti-inflammatory effect, reduces allergic reactions, and soothes irritated skin. Balloon vine flower/leaf/vine extract may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

Helianthus Annuus Seed Oil Unsaponifiables is a fraction of sunflower seed oil that has not been saponified during the refining and recovery process of sunflower seed oil fatty acids. It is rich in linoleic acid, an essential fatty acid, and helps maintain the epidermal barrier and damaged skin barrier. It is effective for dry and damaged skin by soothing and stabilizing it. Unsaponifiable sunflower seed oil may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

Blue Tanji Flower Oil (Tanacetum Annuum Flower Oil) is a volatile oil extracted from blue tanji flowers. It can be obtained by steam distillation of the flowers and stems. During this process, Chamazulene, one of the oil's chemical components, is released. The released Camazulene changes color to dark blue due to the heat applied during the distillation process. The blue Camazulene obtained in this way has an excellent effect in protecting and soothing the skin. In addition to chamazulene, blue tanji flower oil also contains Sabinene and Camphor. Sabinene acts as an effective anti-inflammatory agent for the skin, and Camphor has the effect of reducing inflammation in the body. Furthermore, blue tanji flower oil has excellent anti-allergenic properties to the extent that it has been used as an antihistamine in traditional Chinese medicine. Blue tanji flower oil may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

Triethyl Citrate is an ingredient obtained by fermenting natural ethanol and natural citric acid. It is non-toxic, eco-friendly, and biodegradable. It does not accumulate in the body and decomposes, putting a burden on the body. It has few features. This triethyl citrate has the effect of eliminating bad odors by inhibiting the esterase activity of bacteria, and thus has the effect of suppressing body odor in patients suffering from itching and atopy. In addition, it has a high anti-oxidation ability even in high heat and fire, so it prevents oxidation of cosmetic compositions and extends the shelf life. Triethyl citrate may be included in an amount of 0.1 to 10% by weight based on the total weight of the cosmetic composition.

The cosmetic composition for alleviating itching of the present invention has an excellent effect in relieving itching caused by dryness by simultaneously containing damask rose flower water, prickly pear seed oil, and natural trehalose as essential active ingredients, and in addition, millet seed extract. , blackcurrant seed oil, balloon vine flower/leaf/vine extract, unsaponifiable sunflower seed oil, shield mushroom extract, blue tanji flower oil, and triethyl citrate are further included as active ingredients, in addition to drying. By complexly and gradually blocking, removing or emulsifying various factors that cause skin itching, such as inflammation, sensitivity, atopic dermatitis, skin pH imbalance through cleaning, and skin microbial imbalance, and restoring damaged skin to health, skin itchiness is reduced. can be fundamentally solved.

In particular, when using a mixture of blackcurrant seed oil, balloon vine flower/leaf/vine extract, and unsaponifiable sunflower seed oil, it reduces skin irritants, replenishes lipids, and has anti-inflammatory properties to relieve itching and sensitive skin. It has an excellent effect in calming down. In other words, it has the effect of relieving acute and chronic skin irritation and minimizing inflammatory processes.

And when using a mixture of damask rose flower water, natural trehalose, and triethyl citrate, it has an excellent effect in suppressing body odor in patients suffering from itching and atopy.

And when using a mixture of natural trehalose, millet seed extract, and Lactobacillus fermentation, which can be included as one of the additives, it has an excellent effect in controlling microbial imbalance by supplying beneficial microorganisms to the skin.

And when using a mixture of rose damask water, millet seed extract, and Lactobacillus fermentation, which can be included as one of the additives, it has an excellent effect in controlling pH balance by neutralizing alkalized skin pH.

Also, when using a mixture of shield mushroom extract, balloon vine flower/leaf/vine extract, blackcurrant seed oil, and blue tanji flower oil, it has an excellent effect in alleviating itching by blocking the activation of TRPV1, the main mediator of itching.

Meanwhile, the cosmetic composition for alleviating itchiness of the present invention adds one or more additives such as skin conditioning agent (softener), pH adjuster, moisturizer, lubricant, antibacterial agent, preservative, formulation stabilizer, surfactant, antioxidant, and flavoring agent. You can include more.

Specifically, jojoba esters obtained through transesterification of jojoba oil, hydrogenated jojoba oil or mixtures thereof, Lactobacillus ferment, a product obtained by fermenting the microorganism Lactobacillus, and rosemary leaf extract. (Rosmarinus officinails leaf extract), sunflower seed oil (Helianthus annuus seed oil), jojoba ester oil or Queensland nut (macadamia seed), which is a product obtained through hydrogenation or transesterification of oil extracted from jojoba seed or Queensland nut (macadamia) seed. Ester oil, Squalene, which acts as a sterilizer, Propanediol, which acts as an antibacterial, moisturizing and preservative, and Butylene Glycol, which helps active ingredients to be absorbed into the skin and stabilizes the product formulation. glycol), glycerin for lubrication and moisturizing, octyl dodecanol to help dissolve and keep the skin supple, and phytosteryl macadamiate (an ether that combines phytosterols and fatty acids derived from macadamia oil). Phytosteryl macadamiate, phytosterol, skin conditioning agent, surfactant, polyglyceryl-6 caprylate as an emulsifier, antioxidant and tocopherol to prevent skin moisture evaporation, and flavoring agent. and proline as a skin conditioning agent, sodium levulinate as a skin conditioning agent that can soften the skin and prevent moisture from escaping, and sodium benzoate as a flavoring agent and preservative. ), potassium sorbate, and citric acid may further be included, and the specific types are not particularly limited thereto.

When such additives are added, based on the total weight of the cosmetic composition, jojoba ester is 3 to 10% by weight, propanediol is 2 to 7% by weight, butylene glycol is 1 to 5% by weight, and Lactobacillus fermentation is added. Octyldodecanol may be included at 0.1 to 3% by weight, and octyldodecanol may be included at 0.1 to 3% by weight, and other additives may be included at 0.1 to 1% by weight each.

Meanwhile, the cosmetic composition for relieving skin itching of the present invention is preferably a mist type that can be sprayed so that it can be easily, quickly and uniformly applied to the skin, including the face, and can be applied to a cosmetic composition for skin care. Specifically, it may be an oil-in-water cosmetic composition consisting of a moisture layer and an oil layer, and more specifically, it is preferably a cosmetic composition containing 60 to 90% by weight of the moisture layer and 10 to 40% by weight of the oil layer, based on the total weight. Here, the moisture layer may be a layer composed of a mixture of damask rose flower water, triethyl citrate, and trehalose, and the oil layer may be a mixture of prickly pear seed oil, blackcurrant seed oil, blue tanji flower oil, shield mushroom extract, and balloon vine flowers/leaves. /It may be a layer composed of a mixture of vine extract, millet seed extract, and unsaponifiable sunflower seed oil. The ingredients can be mixed using a conventional mixing method known in the art, for example, a mixing method that involves sufficient stirring after mixing.

Hereinafter, preferred embodiments of the present invention will be described in detail. The embodiment configurations described in this specification are only the most preferred embodiments of the present invention and do not represent the entire technical idea of the present invention, so there are various equivalents and modifications that can replace them at the time of filing the present application. You must understand that it is possible.

Example: Preparation of cosmetic composition

Based on the total weight of the cosmetic composition, 66.5% by weight of damask rose flower water, 1% by weight of prickly pear seed oil, 1% by weight of natural trehalose, 1% by weight of millet seed extract, 1% by weight of shield mushroom extract, 1% by weight of triethyl citrate. %, blackcurrant seed oil 1% by weight, blue tanzi flower oil 1% by weight, balloon vine flower/leaf/vine extract 1% by weight, sunflower seed oil unsaponifiable 1% by weight, jojoba ester 5% by weight, propanediol 5% by weight %, butylene glycol 3% by weight, glycerin 3% by weight, lactobacillus fermentation 1% by weight, octyldodecanol 1% by weight, rosemary leaf extract 0.5% by weight, squalene 0.5% by weight, phytosteryl macadamiate 0.5 Weight %, phytosterol 0.5% by weight, sunflower seed oil 0.5% by weight, jojoba oil and Queensland nut ester oil 0.5% by weight, polyglyceryl-6 caprate 0.5% by weight, tocopherol 0.5% by weight, proline 0.5% by weight, sodium levuli A cosmetic composition was prepared by mixing 0.5% by weight of nate, 0.5% by weight of sodium benzoate, 0.5% by weight of potassium sorbate, and 0.5% by weight of citric acid and stirring thoroughly. Afterwards, it was put into a spray container and commercialized as a mist.

Experimental Example 1: Evaluation of skin moisturization and itching improvement

As shown in Table 1 below, 24 Korean women with an average age of 48.50 ± 6.62 years and dry skin with a moisture value of 29 or less measured using Corneometer® CM825 were tested for improvement in skin moisturization, sustained effect of skin moisturization, and skin dryness. An evaluation of the itching relief caused by was conducted.

Skin type of study subjects skin type forearm facial area Number of people (persons) percentage(%) Number of people (persons) percentage(%) Intelligence 0 0.00 0 0.00 neutrality 0 0.00 0 0.00 inattention 24 100.00 24 100.00 Complexity 0 0.00 0 0.00

The test method is when you feel itchiness due to dryness more than twice a day for 4 weeks, shake the product sufficiently on the right forearm and face and spray 3 to 4 times per use, and spray the product on the left forearm once a day. After shaking sufficiently, sprayed 3 to 4 times. Each measurement method is as follows.

(1) Measurement of improvement in moisturizing 2.5mm of skin

To evaluate the moisture content of 2.5mm of skin, the right cheek area of the study subject was measured and analyzed using Moisturemeter D before and after 4 weeks of use of the product. The analysis value used was TDC (Tissue Dielectric Constant), which represents a value proportional to the total moisture content of the tissue. When the analysis value increases statistically significantly after 4 weeks of use compared to before use, it means that 2.5mm of skin moisture is improved.

(2) Measurement of 24-hour skin moisturizing effect

To evaluate the effect of maintaining skin moisturization for 24 hours, the left forearm of the study subject was measured and analyzed using Epsilon E100 before use of the product, after one use, and 24 hours after use. The analysis value used was the Epsilon value, which refers to the amount of moisture on the skin surface in contact with the Epsilon E100 sensor. As the skin moisture level increases, the brightness of the image results increases, making the blue part appear closer to white. When the analysis value increases statistically significantly after one use and 24 hours after use compared to before use, it means that the skin moisturizing effect lasts for 24 hours.

(3) Measurement of temporary relief from itching caused by dry skin

Specifically, the amount of skin moisture was measured on the left forearm of the study subject using Epsilon E100 before and after 4 weeks of use, and the Epsilon value, which refers to the amount of moisture on the skin surface in contact with the Epsilon E100 sensor, was used as the measurement value. As the skin moisture level increases, the brightness of the image results increases, making the blue part appear closer to white.

And the amount of skin moisture loss was measured on the left forearm of the study subjects using Tewameter® TM 300 before and after 4 weeks of use of the product. CMRWJDRKQT used the TEWL (Transepidermal Water Loss) value, which means the degree of water release from the epidermis.

In addition, the VAS evaluation of itchiness due to dryness uses a Visual Analogue Scale (VAS) to objectively categorize subjective skin itchiness, and measures the dryness currently felt by the research subject on a 10cm horizontal line before and after 4 weeks of use of the product. The degree of itchiness was indicated. The length from the point marked with no itch (0) was used as the analysis value.

Compared to before using the product, when the amount of skin moisture increases statistically significantly after 4 weeks of use, and the amount of skin moisture loss and the itching VAS evaluation index due to dryness statistically significantly decrease, it means that the itching caused by skin dryness has been temporarily relieved. do.

The compliance with the use of the cosmetic composition of a total of 24 people who completed the experiment was shown in Table 2 below.

Compliance of study subjects Maximum compliance (%) Lowest compliance (%) Average compliance (%) 100.00 98.21 99.85

As a result of measuring the improvement in moisturizing of 2.5mm skin, as shown in Table 3 and Figure 1 below, moisturizing of skin (2.5mm) was significantly increased by 1.42% after 4 weeks of use (p<0.05). Therefore, it was judged to be a product that helps improve moisturization of 2.5mm of skin.

Skin (2.5mm) moisture measurement results When to measure Mean±standard deviation Rate of change (%) Before use 32.08±2.67 - After 4 weeks of use 32.53±2.69 1.42

As a result of measuring the effect of maintaining skin moisturization for 24 hours, as shown in Table 4 and Figure 2 below, the amount of skin moisture significantly increased by 636.59% after one use and by 114.42% after 24 hours of use (p<0.05). Therefore, it was judged to be a product that helps maintain skin moisturization for 24 hours. Figure 3 shows the image results for one of the study subjects before use, after use once, and after use for 4 weeks. Compared to before use, the brightness increased after use once and after use for 4 weeks, so the blue part became white. I could see that it had changed closely.

Measurement results of 24-hour skin moisturizing effect When to measure Mean±standard deviation Rate of change (%) Before use 5.69±1.74 - After one use 41.92±6.05 636.59 After 4 weeks of use 12.20±3.10 114.42

As a result of evaluating the temporary relief of itchiness caused by skin dryness, as shown in Table 5 and Figure 4 below, the skin moisture content significantly increased to 71.27% after 4 weeks of use (p<0.05). And as shown in Table 6 and Figure 5 below, the amount of skin moisture loss was significantly reduced to 1.93% after 4 weeks of use (p<0.05). And as shown in Table 7 and Figure 6 below, the itching VAS evaluation index due to dryness significantly decreased to 64.25% after 4 weeks of use (p<0.05). Therefore, it was judged to be a product that helps temporarily relieve itching caused by dry skin. Figure 7 shows the image results before and after 4 weeks of use for one of the study subjects. It can be seen that the brightness increased after 4 weeks of use compared to before use, and the blue part changed to closer to white.

Skin moisture measurement results When to measure Mean±standard deviation Rate of change (%) Before use 5.74±2.26 - After 4 weeks of use 9.82±3.02 71.27

Skin moisture loss measurement results When to measure Mean±standard deviation Rate of change (%) Before use 11.96±1.95 - After 4 weeks of use 11.73±1.81 1.93

VAS evaluation measurement results for itchiness due to dryness When to measure Mean±standard deviation Rate of change (%) Before use 5.91±0.62 - After 4 weeks of use 2.11±0.99 64.25

In addition, as a result of observing adverse reactions such as the study subjects' external symptoms (erythema, edema, psoriasis, scaling, etc.) and symptoms perceived by the study subjects (itching, burning, stiffness, tingling, etc.), there were no significant skin damage during the experiment period. No adverse reactions occurred.

Experimental Example 2: Evaluation of suitability for use on acne-prone skin

As shown in Table 8 below, an evaluation of the suitability of use for acne-prone skin was conducted on 21 Koreans with an average age of 27.62 ± 6.55 years who had oily skin type and inflammatory lesions (papules, nodules) and acne on their backs.

Skin type of study subjects skin type Number of people (persons) percentage(%) Intelligence 21 100.00 neutrality 0 0.00 inattention 0 0.00 Complexity 0 0.00

The experimental method was to shake the product sufficiently twice a day (morning and evening), pump it 3 to 4 times, spray it sufficiently, let it absorb, and use it for 4 weeks. Then, before and after use were compared. A skin specialist performed a visual evaluation to identify inflammatory lesions (papules, nodules) on the study subjects' backs, and then counted and recorded the exact number. Through this, the overall acne severity was evaluated using the KAGS (Korean Acne Grading System) grade. Based on this, at the last visit, the dermatologist made a final judgment on the suitability for use on acne-prone skin. In addition, the back area of the study subject was photographed using a digital camera as proof of the dermatologist's visual evaluation before and after 4 weeks of use.

The compliance with the use of the cosmetic composition of a total of 21 people who completed the experiment was shown in Table 9 below.

Compliance of study subjects Maximum compliance (%) Lowest compliance (%) Average compliance (%) 100.00 87.50 98.30

As a result of evaluating the suitability for use on acne-prone skin, as shown in Table 10 and Figure 8 below, papules, which are inflammatory lesions, were statistically significantly reduced after 4 weeks of use (p<0.05). Additionally, as shown in Table 11 and Figure 9 below, the number of nodules was also statistically significantly reduced after 4 weeks of use (p<0.05). Figure 10 shows the results of imaging the back of one of the study subjects, and it can be visually confirmed that the number of papules and nodules has decreased.

Papule count evaluation results When to measure Mean±standard deviation Rate of change (%) Before use 27.05±10.70 - After 4 weeks of use 21.57±8.51 20.25

Nodule count evaluation results When to measure Mean±standard deviation Rate of change (%) Before use 0.29±0.64 - After 4 weeks of use 0.10±0.30 66.67

In addition, as shown in Table 12 and Figure 11 below, the KAGS grade was statistically significantly reduced by 8.51% after 4 weeks of use ((p<0.05).

KAGS EMDRMQ evaluation results When to measure Mean±standard deviation Rate of change (%) Before use 2.24±0.44 - After 4 weeks of use 2.05±0.50 8.51

Therefore, as a result, the cosmetic composition of the present invention was determined to be suitable for use on acne-prone skin. In addition, as a result of observing adverse reactions such as the study subjects' external symptoms (erythema, edema, psoriasis, scaling, etc.) and symptoms perceived by the study subjects (itching, burning, stiffness, tingling, etc.), there were no significant skin damage during the experiment period. No adverse reactions occurred.

Experimental Example 3: Hypoallergenicity evaluation

Hypoallergenicity evaluation was conducted on 32 Koreans (1 male, 31 female) with an average age of 49.66 ± 6.69 years and the skin type shown in Table 13 below.

Skin type of study subjects skin type Number of people (persons) percentage(%) Intelligence 0 0.00 neutrality One 3.13 inattention 24 75.00 Complexity 7 21.87

The experimental method was to wipe the research subject's back with 70% ethanol, dry it, load 20㎕ of the cosmetic composition according to the example into IQ Ultimate®, fix it on the skin, and attach it to the skin for 24 hours. The first visual evaluation was conducted by a dermatologist 30 minutes after the patch was removed, and the second visual evaluation was conducted 24 hours after the patch was removed.

Visual evaluation was performed based on the Personal Care Products Council (PCPC) Safety Testing Guidelines and the International Contact Dermatitis Research Group (ICDRG) criteria (see Table 14 below). Based on these evaluation values, the skin irritation index was calculated according to Equation 1 below, and the skin irritation of the study product was evaluated by referring to the skin irritation index number according to Table 15 below.

Skin irritation evaluation criteria Grade standard 0 No reaction One Slight erythema, either spotty or diffuse 2 Moderate uniform erythema 3 Intense erythema with edema 4 Intense erythema with edema & vesicles

Skin irritation index table skin irritation index skin irritation range 0.00~0.25 hypoallergenic range 0.26~1.00 Mild stimulation range 1.01~2.50 medium stimulation range 2.51~4.00 Strong stimulation range

As a result of the skin irritation test, all 32 people were evaluated as 0 Grade, which is no reaction, in the first and second visual evaluations, resulting in a skin irritation index of 0.00. Therefore, as a result, the cosmetic composition of the present invention was determined to be within the hypoallergenic range. In addition, as a result of observing adverse reactions such as external symptoms of the research subjects (erythema, edema, psoriasis, scaling, etc.) and symptoms perceived by the research subjects (itching, burning, stiffness, tingling, etc.), there were no significant skin damage during the experiment period. No adverse reactions occurred.

Although embodiments of the present invention have been described above with reference to the attached drawings, those skilled in the art will understand that the present invention can be implemented in other specific forms without changing its technical idea or essential features. You will be able to understand it. Therefore, the embodiments described above should be understood in all respects as illustrative and not restrictive.

Claims (5)

An oil-in-water cosmetic composition consisting of 60 to 90% by weight of water layer and 10 to 40% by weight of oil layer based on the total weight,
Based on the total weight of the composition,
The moisture layer contains 50 to 80% by weight of damask rose flower water, 0.1 to 10% by weight of natural trehalose, and 0.1 to 10% by weight of triethyl citrate,
The oil layer contains 0.1-10% by weight of prickly pear seed oil, 0.1-10% by weight of millet seed extract, 0.1-10% by weight of shield mushroom extract, 0.1-10% by weight of blackcurrant seed oil, and balloon vine flower/leaf/vine extract. Contains 0.1 to 10% by weight, 0.1 to 10% by weight of unsaponifiable sunflower seed oil, and 0.1 to 10% by weight of blue tansy flower oil,
The damask rose flower water is an aqueous solution obtained by steam distillation of damask rose flowers,
The composition further includes an additive containing fermented Lactobacillus,
A cosmetic composition for alleviating skin itching caused by atopic dermatitis and dryness. According to paragraph 1,
Characterized in that the pH of the millet seed extract is 4.0 to 5.5.
A cosmetic composition for alleviating skin itching caused by atopic dermatitis and dryness. According to paragraph 1,
The shield mushroom extract is a mixture of bunch shield mushroom extract and woolly shield mushroom extract at a weight ratio of 1:1 to 2:1,
A cosmetic composition for alleviating skin itching caused by atopic dermatitis and dryness. delete According to paragraph 1,
The cosmetic composition is characterized in that it is a mist type that can be sprayed by spraying.
A cosmetic composition for alleviating skin itching caused by atopic dermatitis and dryness.