CN1541666A - Chinese traditional medicine composition for treating bedsore and acute soft tissue injury - Google Patents
Chinese traditional medicine composition for treating bedsore and acute soft tissue injury Download PDFInfo
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Abstract
The medicine composition is prepared with rhubarb, arborvidae leaf, phellodendron bark, eupatorium, mint, borneol and menthol. The present invention features that the said medicine composition may be added with conventional supplementary material or excipient to prepare various preparations, including spray, aerosol, liniment, ointment and cataplasma. The medicine composition of the present invention may be used in treating sore ulcer, bedsore, acute soft tissue damage, etc. owing to its functions of resisting inflammation, diminishing swelling, relieving pain and bacteriostasis.
Description
Technical field
The present invention relates to a kind of herbal mixture compositions, particularly relate to a kind of herbal mixture compositions for the treatment of decubital ulcer, acute soft tissue injury.
Background technology
In motherland's medicine and pharmacology, external treatment and medicine for external use have a long history, in secular medical practice, the medicine scholar is according to the needs of external treatment, formulated abundant external preparation and various dosage form, as the powder that is used to apply ointment or plaster, unguentum, be used to be coated with medicated wine, the oil preparation put on the skin, and be used to smoke lotion of washing etc.Traditional external preparation kind of using till today is a lot, as " Anisodus carniolicoides C.Y.Wu et C.Chen that records of Chinese pharmacopoeia, JIUYISAN, Nine Sages Powder, SHANGSHI ZHITONG GAO, FENGLIAOXING FENGSHI DIEDA YAOJIU, ruyi jinhuang powder, ruyi jinhuang san, zijin troche etc., ZHENGHONGHUA YOU arranged, the spending wet goods in vain of import, yet these are wide in variety to have certain curative effect to traumatic injury, rheumatic arthralgia, and be used for skin more and do not have damaged person, and having anti-inflammation detumescence, the wound healing effect of damaged person, decubital ulcer etc. not good to acute soft tissue injury skin, in fact most of external used medicines can not be used for the damaged person of skin.
On the other hand, though more or less there are some shortcomings in above-mentioned conventional medicament prolonged application in clinical.As the prescription complexity, be example with the dog skin plaster, form by 29 flavor Chinese medicines, be difficult to get clear primary and secondary; Or the heavy medical material of Han You Expensive in the side, even forbidden drug, as Os Tigris, Moschus etc., make the production cost height; Or preparation technology is backward, and the cycle is long, and the preparation of medicated wine is especially true; Or skin absorbs is poor, and it is slow to take effect; Or contain toxic medicament, skin there is zest, even anaphylaxis; Or use inconvenience, easy pollution clothes etc.; And the quality control of traditional external preparation is generally all more coarse, or is difficult to carry out Quality Control, even does not carry out Quality Control etc. fully.Therefore develop a kind of easy to usely, evident in efficacy, especially acute soft tissue injury is had good effect with the skin injury person, with low cost, the novel medicine for external use that is easy to Quality Control has the important clinical meaning.
Treating patients with decubitus is stubborn problem very clinically, lacks effective medicine so far.The general abroad general hospital of decubital ulcer sickness rate reaches 3-14%, then can be spinal cord injury person up to 25-85%, and 8% is relevant with death, and elderly patients' mortality rate relevant with decubital ulcer is 23-37%.Decubital ulcer is easy to cause infection, in case worsen, can bring great misery to patient, even septicemia takes place and causes death.The treatment of decubital ulcer is a Comprehensive Treatment, but topical therapeutic especially local application be still the key of curing decubital ulcer.Up to now, Shang Weijian has pair decubital ulcer that the Chinese medicine preparation of good efficacy is arranged; Western medicine disinfectant and free-iodine solution, ethanol, hibitane, soap abluent and hydrogen peroxide (hydrogen peroxide) etc., though can be used for decubital ulcer, but only be applicable to the not damaged person of decubital ulcer surrounding skin, corrosivity to wound itself is then too big, and influence granulation tissue growth and wound healing, other are as metronidazole solution, furacilin solution etc., and curative effect is also undesirable.U.S. nursing dept. avoids using anti-infective when also advising nursing decubital ulcer March nineteen ninety.Decubital ulcer external treatment curative effect horizontal aspect, the attached First Academy of domestic Zhongshan University report adds gentamycin soak treatment decubital ulcer with local infrared ray radiation, and in the 47 routine patients with bedsore, 6 routine inflammatory phase healed in one month entirely as a result, but 34 examples did not heal at 2-6 month, and the band decubital ulcer is left hospital.And U.S. Frantz reports that 149 examples treat patients with decubitus and on average needs 147 days.Illustrate that decubital ulcer is still the difficult problem of medical domain so far, it not only reduces patient's quality of life, and consumes medical nurse fees usefulness hugely, and therefore, developing a kind ofly has the medicine of good efficacy to decubital ulcer, has important clinical meaning and economic results in society.
Summary of the invention
One object of the present invention is to disclose a kind of new treatment decubital ulcer, the Chinese medicine composition of acute soft tissue injury; Another object of the present invention is the method for the Chinese medicine composition of a kind of new treatment decubital ulcer of open preparation, acute soft tissue injury.
Pharmaceutical composition of the present invention is made up of following raw material medicaments, each crude drug component and proportioning following (by weight):
Radix Et Rhizoma Rhei 250-300 weight portion, Cacumen Platycladi 250-300 weight portion, Cortex Phellodendri 120-160 weight portion, Herba Lycopi 120-160 weight portion, Herba Menthae 120-160 weight portion, Borneolum Syntheticum 3-8 weight portion, Mentholum 0.5-2 weight portion.
Aforementioned pharmaceutical compositions can add conventional adjuvant or excipient, makes various pharmaceutical preparatioies, comprises spray, aerosol, liniment, unguentum, cataplasma.
This preparation of drug combination method:
Get Radix Et Rhizoma Rhei decoction piece, add 6～10 times of water gagings and soaked 0.5～1 hour, decocted 1～2 hour, filter; Add 5～8 times of water gagings more respectively and decoct 2～3 times, boiled 1～2 hour at every turn, filter; Merge three times decocting liquid, concentrate medical material and medicinal liquid to 1: 1,75～80 ℃ of heat are surveyed relative density and are 1.05～1.08, and are standby; Four Chinese medicines such as Cortex Phellodendri, Cacumen Platycladi, Herba Lycopi and Herba Menthae, adding 6～10 times of water gagings soaked 0.5～1 hour, decocted 1～2 hour, filtered; Add 5～8 times of water gagings again and decocted 1～2 hour, filter; Merge decocting liquid twice, medical material and medicinal liquid are concentrated into 1: 1, and 75～80 ℃ of heat are surveyed relative density and are 1.02～1.04, and are standby; Merge above-mentioned concentrated solution, add ethanol and make in right amount and contain alcohol amount and reach 70～90%, left standstill 12～48 hours, filter, reclaim ethanol, concentrated solution is put cold, filters; Borneolum Syntheticum, Mentholum, chlorobutanol dissolve in right amount with ethanol, add in the filtrate, add glycerol, polyvinylpyrrolidone again, stir evenly, and make various pharmaceutical preparatioies through conventional technology.
Chinese traditional compound medicine of the present invention has good anti-inflammation detumescence, analgesia, bacteriostasis, treatment decubital ulcer, acute soft tissue injury as sprain, local damage such as contusion, aspect effects such as red and swollen heat pain, traumatic infection are obvious.
The present invention has following pharmacological action: can significantly suppress by rat paw edema due to the Ovum Gallus domesticus album, this effect strengthens with the increase of dosage, and resist inflammation on repercussive function continues 6 hours; Can suppress by the swelling of Oleum Tiglii induced mice ear; Inhibition is raise by the rat skin vascular permeability due to the histamine; Analgesic activity is preferably arranged, and its analgesic activity obviously is better than the positive control drug musk shuhuo essence; To staphylococcus aureus, the epidermis coccus, micrococcus scarlatinae has certain inhibitory action; The effect that improves local microcirculation is arranged.
Following experimental example is used to further specify the present invention
Experimental example 1:
1, is subjected to the reagent thing
(1) Chinese traditional compound medicine (present composition preparation), lot number 950803 cures mainly decubital ulcer, acute soft tissue injury etc.
(2) musk shuhuo essence, lot number 950626, Wuhan Institute Of Sport body-building pharmaceutical factory produces.Cure mainly various closure athletic injury, traumatic injury, diseases such as neck-shoulder pain, lumbago and leg pain.And dosage form is identical with Chinese traditional compound medicine with usage, so select as positive control drug in the anti-inflammatory, repercussive and analgesic experiment.
(3) sterile saline, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med produces, lot number 950612.
2, laboratory animal
The NIH mice, male, body weight 18-22g, the animal quality certification number: 94022; The SD rat, male, body weight 160-220g, the animal quality certification number: 94023.All animals are all available from Department of Health of Guangdong Province medical experiment animal field.
Animal is divided into four groups at random: (1) low dose group: 100% Chinese traditional compound medicine is coated with outward.
(2) high dose group: 200% Chinese traditional compound medicine is coated with outward.
(3) positive controls: musk shuhuo essence is coated with outward.
(4) substrate matched group: normal saline is coated with outward.
3, experimental technique: (rat paw edema experiment " Ovum Gallus domesticus album method ")
With the 160-220g rat, male, 40, random packet, every group 10, rat anesthesia (3% pentobarbital sodium before the experiment, 30mg/kg IP), respectively organize the right back sufficient sole of the foot normal volume of rat (at the positive clear graticule of doing of foot), coating then with the measurement of improvement volumetric method, 0.5 coating for the second time after hour, at the right hind foot sole of the foot subcutaneous injection 0.1ml fresh albumen (100%), coating is once measured and is caused scorching back 1,2,4,6 hour right hind foot sole of the foot volume more simultaneously after 1 hour, coating once the results are shown in Table 1 after each the measurement
4, experimental result
Table 1, Chinese traditional compound medicine suppress the swelling of rat toes (ml, x ± s)
N 1h 2h 4h 6h
100% herbal mixture
Preparation 10 0.86 ± 0.15** 0.69 ± 0.20** 0.44 ± 0.16** 0.32 ± 0.19**
200% herbal mixture, 10 0.89 ± 0.15*, 0.77 ± 0.23*, 0.48 ± 0.15*, 0.25 ± 0.16**
Preparation 10 0.87 ± 0.16** 0.80 ± 0.22* 0.47 ± 0.24* 0.36 ± 0.18*
Musk shuhuo essence 10 1.12 ± 0.24 0.98 ± 0.18 0.66 ± 0.18 0.56 ± 0.16
The substrate matched group
Annotate: with the substrate matched group than * p＜0.05 * * p＜0.01 * * * p＜0.001 time with
Conclusion: Chinese traditional compound medicine can significantly suppress by rat toes swelling due to the Ovum Gallus domesticus album, and this effect strengthens with the increase of dosage, and resist inflammation on repercussive function continues 6 hours.
Experimental example 2: Oleum Tiglii induced mice ear inflammation test (experiment material is with experimental example 1)
With the 18-22g mice, male, 52, random packet, 13 every group.Each organizes mice respectively at two sides coating before and after the left ear, 0.5 coating is once again after hour, coating is coated with the mixing proinflammatory agent in ear two sides, every Mus left side after 0.5 hour and (includes 2% Oleum Tiglii for the second time, 20% dehydrated alcohol, 5% distilled water, 73% ether) 0.05ml causes inflammation, cause scorching back and distinguished coating once again in 0.5,1,1.5 hour, put to death animal after causing scorching 4.5 hours, cut two ears along the auricle baseline, lay the same position of ears disk with diameter 9mm card punch, electronic analytical balance is weighed, calculate the swelling degree: swelling degree=left auricle weight-auris dextra sheet is heavy, the results are shown in Table 2
Table 2, Chinese traditional compound medicine suppress mice ear swelling test (x ± s)
N swelling degree
100% Chinese traditional compound medicine, 13 8.61 ± 1.31**
200% Chinese traditional compound medicine, 13 8.80 ± 1.85**
Musk shuhuo essence 13 10.00 ± 2.44
Substrate matched group 13 11.12 ± 2.29
Conclusion: Chinese traditional compound medicine can suppress the swelling by Oleum Tiglii induced mice ear.
Experimental example 3: the test of rat skin vascular permeability
With the 160-220g rat, male, 44, random packet, 11 every group.Rat abdomen is shaved hair, coating 0.3ml, and coating is once again after 0.5 hour.For the second time coating is after 0.5 hour, intradermal injection 1mg/ml histamine 0.1ml (NS joins), the quiet immediately 1% blue 4ml/kg (NS joins) of she Wen, administration for the third time simultaneously.Sacrificed by decapitation animal after 20 minutes with painted skin peeling, is cut blue speckle, shred, put into 5mlNS-acetone solution (3: 7) and soaked centrifugal (2000 rev/mins) 5 minutes 24 hours, supernatant is surveyed OD in the 610mm place, (seepage discharge of representing her Wen orchid of skin with OD) the results are shown in Table 3
Table 3, Chinese traditional compound medicine are to the influence of rat skin vascular permeability (x ± s)
The blue content (OD value) of she Wen of N skin
100% Chinese traditional compound medicine, 11 0.538 ± 0.189*
200% Chinese traditional compound medicine, 11 0.504 ± 0.140**
Musk shuhuo essence 11 0.522 ± 0.199*
Substrate matched group 11 0.696 ± 0.153
Conclusion: Chinese traditional compound medicine can suppress to be increased by the rat skin vascular permeability due to the histamine.
From above-mentioned three anti-inflammation detumescence result of the tests, the effect of Chinese traditional compound medicine is suitable with the positive control drug musk shuhuo essence.Wherein to the inhibitory action of mice ear, Chinese traditional compound medicine is better than the positive control drug musk shuhuo essence.
Experimental example 4: analgesic test (radiant-heat method)
With the 18-22g male mice, fixing, outside tail is exposed to, dolorimeter (R85-2 type) optical focus is aimed at 1/3 place under the Mus tail, the constant distance of Mus tail and light source, from time of exposing to whipping threshold of pain as this Mus, screening is gone less than 5 seconds or greater than 30 seconds persons with electronic stopclock record.With qualified mice random packet, 10 every group.Each is organized mice and surveys threshold of pain secondary, at every turn every 5 minutes, get average as the administration of this Mus before pain threshold.Survey back mousetail coating, coating for the second time after 0.5 hour is measured after the administration for the second time 30,90,150 minutes the threshold of pain, as 30 seconds still reactionless, mice is taken out, in order to avoid scald, its threshold of pain was in 30 seconds, secondary was measured each coating of back once in 30 and 90 minutes.The results are shown in Table 4
Table 4, Chinese traditional compound medicine analgesic test (radiant-heat method) (second, x ± s)
N 1h 2h 3h
100% Chinese traditional compound medicine 10 2.40 ± 2.45 3.71 ± 2.10*** 2.33 ± 2.55
200% Chinese traditional compound medicine 10 3.04 ± 3.05 4.65 ± 2.70***, 2.54 ± 1.52*
Musk shuhuo essence 10 1.58 ± 2.59 1.95 ± 1.63 1.88 ± 2.29
Substrate matched group 10 1.58 ± 1.38 0.91 ± 1.18 0.77 ± 1.49
Conclusion: radiant-heat method analgesic test result shows that Chinese traditional compound medicine has analgesic activity preferably, and its analgesic activity obviously is better than positive controls medicine musk shuhuo essence.
Experimental example 5: extracorporeal bacteria inhibitor test (K-B disk diffusion method)
Get the filter paper dick of sterilizing, be soaked in the Chinese traditional compound medicine, wait to do standby.Culture medium adopts M-H agar and adds sheep blood 5% agar, and the K-B disk diffusion method is adopted in drug sensitivity test.Be about to contain the scraps of paper of a certain amount of Chinese traditional compound medicine, smooth on the M-H agar plate of inoculating tested bacterium.Antibacterials in the scraps of paper are dissolved in the culture medium, and to diffusion all around, thereby antibacterial ring appears in bacteria growing inhibiting.
Table 5, Chinese traditional compound medicine bacteriostatic test result
Strain inhibition zone diameter (mm)
Lot number 950,728 950,803 950811
Staphylococcus aureus 11 15 13
Staphylococcus epidermidis 897
Micrococcus scarlatinae 11 8 10
Escherichia coli drug resistance drug resistance drug resistance
Bacillus pyocyaneus drug resistance drug resistance drug resistance
Conclusion: Chinese traditional compound medicine has certain inhibitory action to staphylococcus aureus, staphylococcus epidermidis, micrococcus scarlatinae, and escherichia coli and bacillus pyocyaneus are not then had the obvious suppression effect.
Experimental example 6: improve the local microcirculation experiment
Rat is divided into four groups at random, 10 every group.
(1) 100% compound Chinese medicinal preparation group (transferring PH is 7.2, does to instil and uses).
(2) 200% compound Chinese medicinal preparation groups (transferring PH is 7.2, does to instil and uses).
(3) (Radix Salviae Miltiorrhizae Injection instils positive controls, 3g/2ml).
(4) substrate matched group.
Experimental technique: rat is with pentobarbital sodium 40mg/kg intraperitoneal injection of anesthesia, abdominal part is shaved hair, makes the long otch of 2cm in the right side stomach wall, pulls out one section ileum loop gently, be tiled on the special lucite perfusion Xiao Chi, intestinal tube below mesentery is fixed on the soft rubber of perfusion Xiao Chi both sides.The perfusion syringe needle of one constant temperature and pressure perfusion bottle is fixed on the perfusion Xiao Chi, fills 37 ℃ of balance Ke Shi nutritional solutions in the bottle, regulating flow velocity is that 30/min makes on its mesentery of slowly flowing through.Observe with XG-5 type microcirculation brain comprehensive quantitative instrument, throw and tiltedly fall to penetrating light, to amplify micro-circulation flow rate in the 40 power microscope field of view (cursor tracking, um/ second), caliber and fluidised form.20ug/10ul instils on mesentery with norepinephrine (NA) injection (Wuhan Pharmaceutical Factory produces, lot number 970104), causes mesentery local microcirculation obstacle, microcirculatory variation in 3 minutes behind the observed and recorded instillation NA.Then in the local instillation medicine of mesentery 0.5ml, microcirculatory variation in 3 minutes behind the recording medicine.Relatively drip before and after the NA and the variation of medication ideocolon mesentery micro-circulation flow rate, fluidised form and caliber.Experimental result sees Table 6.
The scoring of blood flow attitude:
0 grade: achroacyte was assembled (linear flow) 4 minutes
I level: 2-3 cell aggregation becomes the coarse granule shape, do not influence flow velocity (line grain stream).3 minutes
II level: 4-6 cell aggregation becomes the coarse granule shape, visible void shape in the tube chamber (grain grain stream).2 minutes
The III level: hemocyte is gathered into lumps and influences blood flow rate (grain stream, grain unhurried current).1 minute
The IV level: blood flow stops or forming microthrombus, and bright section (grain pendulum stream or stagnation) arranged in the tube chamber.0 minute
Table 6 compound Chinese medicinal preparation is to the microcirculatory influence of mesentery live body (X ± S)
The velocity flow pattern caliber
Medicine N time point
(um/s) (integration) (um)
11 NA preceding 1550.0 ± 415.38 3.3 ± 0.79 5.9 ± 0.54 in 100%
3min 162.4 ± 231.93 0.4 ± 0.51 7.7 ± 0.65 behind the NA is dripped in recurrence due to taking drug side
Preparation drips 3min 768.1 ± 284.01 behind the medicine
* *1.4 ± 0.52
*7.1 ± 0.94
*
10 NA preceding 1432.2 ± 230.20 3.3 ± 0.82 6.2 ± 0.92 in 200%
3min 307.1 ± 277.70 0.7 ± 0.48 7.8 ± 1.13 behind the NA is dripped in recurrence due to taking drug side
Preparation drips 3min 594.4 ± 279.90 behind the medicine
*1.3 ± 0.48
*7.6 ± 1.08
10 NA preceding 1494.0 ± 215.65 3.3 ± 0.48 5.9 ± 0.57
Radix Salviae Miltiorrhizae
Drip 3min 247.3 ± 231.80 0.7 ± 0.48 8.3 ± 0.82 behind the NA
Injection
Drip 3min 974.1 ± 425.25 behind the medicine
* *1.9 ± 0.88
* *6.8 ± 1.23
*
10 NA preceding 1476.3 ± 182.24 3.0 ± 0.47 6.3 ± 0.67
Substrate is right
Drip 3min 205.1 ± 257.91 0.3 ± 0.48 8.6 ± 1.89 behind the NA
According to
Drip 3min 265.9 ± 342.30 0.7 ± 0.67 8.8 ± 2.20 behind the medicine
By table 6 as seen, velocity of blood flow, fluidised form and the caliber of each group before the part drips NA do not have the significance difference; Drip on mesentery after the NA, can cause the local microcirculation obstacle, show as that microcirculation blood flow velocity is slack-off, blood flow reduces, the tube chamber stasis of blood expands, and illustrates that NA has caused microcirculation disturbance.
Compound Chinese medicinal preparation, Radix Salviae Miltiorrhizae Injection have the effect that improves local microcirculation, with the substrate matched group relatively, can significantly alleviate the change of blood flow rate, fluidised form and caliber due to the NA.
Experimental result shows that compound Chinese medicinal preparation can significantly suppress by rat paw edema due to the Ovum Gallus domesticus album, and this effect strengthens with the increase of dosage, and resist inflammation on repercussive function continues 6 hours; Can suppress by the swelling of Oleum Tiglii induced mice ear; Increase by the rat skin vascular permeability due to the histamine; Analgesic activity is preferably arranged, and its analgesic activity obviously is better than the positive control drug musk shuhuo essence; To staphylococcus aureus, the epidermis coccus, micrococcus scarlatinae has certain inhibitory action; The effect that improves local microcirculation is arranged.
The specific embodiment:
Embodiment 1: spray
Radix Et Rhizoma Rhei 295g, Cacumen Platycladi 290g, Cortex Phellodendri 130g, Herba Lycopi 135g, Herba Menthae 135g, Borneolum Syntheticum 4g, Mentholum 0.8g.
Make spray 1000ml, every bottle of 50ml, spray 4-5 every day, or use the gauze soak, every day 2 times.
Embodiment 2: aerosol
Radix Et Rhizoma Rhei 260g, Cacumen Platycladi 270g, Cortex Phellodendri 150g, Herba Lycopi 150g, Herba Menthae 150g, Borneolum Syntheticum 7g, Mentholum 1.5g.
Make aerosol 1000ml, every bottle of 50ml, spray 4-5 every day, or use the gauze soak, every day 2 times.
Embodiment 3: the liniment type
Radix Et Rhizoma Rhei 286g, Cacumen Platycladi 286g, Cortex Phellodendri 143g, Herba Lycopi 143g, Herba Menthae 143g, Borneolum Syntheticum 5g, Mentholum 1g.
Adjuvant: chlorobutanol 5g, glycerol 100ml, the uncommon ketopyrrolidine 30g of poly-second.
We are the seven flavor medicine material altogether, gets Radix Et Rhizoma Rhei and adds 8 times of water gaging dippings 0.5 hour, decocts 1 hour, filters; Add 5 times of water gagings again and decoct secondary, each 1 hour, filter; Merge three times decocting liquid, (medical material: medicinal liquid), heat is surveyed (75～80 ℃) relative density and is 1.05～1.08, and is standby to be concentrated into 1: 1.Four Chinese medicines such as Cortex Phellodendri, Cacumen Platycladi, Herba Lycopi and Herba Menthae add 8 times of water gaging dippings 0.5 hour, decoct 1 hour, filter; Add 5 times of water gagings again and decocted 1 hour, filter; Merge decocting liquid twice, (medical material: medicinal liquid), heat is surveyed (75～80 ℃) relative density and is 1.02～1.04, and is standby to be concentrated into 1: 1.Merge above-mentioned concentrated solution, add ethanol and make in right amount and contain alcohol amount and reach 80%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into about 900ml, put cold, filtration; Borneolum Syntheticum, Mentholum, chlorobutanol dissolve in right amount with ethanol, add in the filtrate, add glycerol, polyvinylpyrrolidone again, stir evenly, and adjust at last and make into 1000ml, packing, promptly.
Bottling, every bottle of 100ml is coated with and puts the affected part on the skin, every day 3-4 time, or use the gauze soak, every day 2 times.
Claims (8)
1, a kind of pharmaceutical composition is characterized in that this pharmaceutical composition made by following crude drug:
Radix Et Rhizoma Rhei 250-300 weight portion, Cacumen Platycladi 250-300 weight portion, Cortex Phellodendri 120-160 weight portion, Herba Lycopi 120-160 weight portion, Herba Menthae 120-160 weight portion, Borneolum Syntheticum 3-8 weight portion, Mentholum 0.5-2 weight portion.
2, a kind of pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following crude drug:
Radix Et Rhizoma Rhei 286 weight portions, Cacumen Platycladi 286 weight portions, Cortex Phellodendri 143 weight portions, Herba Lycopi's 143 weight portions, Herba Menthae 143 weight portions, Borneolum Syntheticum 5 weight portions, Mentholum 1 weight portion.
3, a kind of pharmaceutical composition as claimed in claim 1 is characterized in that this pharmaceutical composition made by following crude drug:
Radix Et Rhizoma Rhei 260 weight portions, Cacumen Platycladi 270 weight portions, Cortex Phellodendri 150 weight portions, Herba Lycopi's 150 weight portions, Herba Menthae 150 weight portions, Borneolum Syntheticum 7 weight portions, Mentholum 1.5 weight portions.
4, as claim 1,2 or 3 described pharmaceutical compositions, it is characterized in that this pharmaceutical composition can add conventional adjuvant or excipient, make various pharmaceutical preparatioies, comprise spray, aerosol, cataplasma, unguentum, liniment.
5, preparation of drug combination method as claimed in claim 4 is characterized in that the preparation method of described pharmaceutical preparation is:
Get Radix Et Rhizoma Rhei decoction piece, add 6～10 times of water gagings and soaked 0.5～1 hour, decocted 1～2 hour, filter; Add 5～8 times of water gagings more respectively and decoct 2～3 times, boiled 1～2 hour at every turn, filter; Merge three times decocting liquid, concentrate medical material and medicinal liquid to 1: 1,75～80 ℃ of heat are surveyed relative density and are 1.05～1.08, and are standby; Four Chinese medicines such as Cortex Phellodendri, Cacumen Platycladi, Herba Lycopi and Herba Menthae, adding 6～10 times of water gagings soaked 0.5～1 hour, decocted 1～2 hour, filtered; Add 5～8 times of water gagings again and decocted 1～2 hour, filter; Merge decocting liquid twice, medical material and medicinal liquid are concentrated into 1: 1, and 75～80 ℃ of heat are surveyed relative density and are 1.02～1.04, and are standby; Merge above-mentioned concentrated solution, add ethanol and make in right amount and contain alcohol amount and reach 70～90%, left standstill 12～48 hours, filter, reclaim ethanol, concentrated solution is put cold, filters; Borneolum Syntheticum, Mentholum, chlorobutanol dissolve in right amount with ethanol, add in the filtrate, add glycerol, polyvinylpyrrolidone again, stir evenly, and make various pharmaceutical preparatioies through conventional technology.
6, preparation of drug combination method as claimed in claim 5 is characterized in that this method is:
Get Radix Et Rhizoma Rhei decoction piece, add 8 times of water gagings and soaked 0.5 hour, decocted 1 hour, filter; Add 5 times of water gagings more respectively and decoct secondary, boiled 1 hour at every turn, filter; Merge three times decocting liquid, medical material and medicinal liquid are concentrated into 1: 1, and 75～80 ℃ of heat are surveyed relative density and are 1.05～1.08, and are standby; Four Chinese medicines such as Cortex Phellodendri, Cacumen Platycladi, Herba Lycopi and Herba Menthae, adding 8 times of water gagings soaked 0.5 hour, decocted 1 hour, filtered; Add 5 times of water gagings again and decocted 1 hour, filter; Merge decocting liquid twice, medical material and medicinal liquid are concentrated into 1: 1, and 75～80 ℃ of heat are surveyed relative density and are 1.02～1.04, and are standby; Merge above-mentioned concentrated solution, add ethanol and make in right amount and contain alcohol amount and reach 80%, left standstill 24 hours, filter, reclaim ethanol, be concentrated into about 900 milliliters, put coldly, filter; Borneolum Syntheticum, Mentholum, chlorobutanol dissolve in right amount with ethanol, add in the filtrate, add glycerol, polyvinylpyrrolidone again, stir evenly, and adjust at last and make into 1000 milliliters, packing, promptly.
7, treat body surface red and swollen heat pain, sore swollen toxin, decubital ulcer as claim 1,2 or 3 described pharmaceutical compositions in preparation; Acute soft tissue injury as wound, is sprained, and dampens; Rheumatic ostalgia, muscular soreness, the application in the medicine of diseases such as transfusion posterior vein inflammation.
8, has application in the medicine of anti-inflammation detumescence, analgesia, bacteriostasis as claim 1,2 or 3 described pharmaceutical compositions in preparation.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2042167A1 (en) * | 2007-09-26 | 2009-04-01 | Aisa Therapeutics | Use of a monoterpene to induce tissue repair |
| CN101874846A (en) * | 2010-07-06 | 2010-11-03 | 浙江中医药大学 | Method for preparing cataplasm for treating soft tissue injury |
| CN102579651A (en) * | 2012-03-19 | 2012-07-18 | 江景华 | Traditional Chinese medicine preparation for treating traumata and bedsore |
| CN102614287A (en) * | 2011-10-20 | 2012-08-01 | 广州中医药大学 | Film-spraying agent for treating acute soft tissue injuries |
| CN102614355A (en) * | 2012-03-27 | 2012-08-01 | 孙静 | Drug composition for treating bedsores |
| CN102698044A (en) * | 2012-06-12 | 2012-10-03 | 唐山职业技术学院 | Preparation method of medicinal composition for treating acne |
| CN114432378A (en) * | 2021-11-17 | 2022-05-06 | 上海市浦东新区六灶社区卫生服务中心 | Traditional Chinese medicine preparation for treating soft tissue injury and preparation method thereof |
| CN114949065A (en) * | 2022-06-06 | 2022-08-30 | 肇庆市中医院 | Traditional Chinese medicine application for treating early traumatic injury and preparation method thereof |
-
2003
- 2003-04-29 CN CN 03124067 patent/CN1276763C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009040420A3 (en) * | 2007-09-26 | 2009-06-25 | Aisa Therapeutics | Use of a monoterpene to increase tissue repair |
| JP2010540497A (en) * | 2007-09-26 | 2010-12-24 | エイザ・セラピューティクス | Use of monoterpenes to increase tissue repair |
| EP2042167A1 (en) * | 2007-09-26 | 2009-04-01 | Aisa Therapeutics | Use of a monoterpene to induce tissue repair |
| CN101874846A (en) * | 2010-07-06 | 2010-11-03 | 浙江中医药大学 | Method for preparing cataplasm for treating soft tissue injury |
| CN102614287A (en) * | 2011-10-20 | 2012-08-01 | 广州中医药大学 | Film-spraying agent for treating acute soft tissue injuries |
| CN102579651B (en) * | 2012-03-19 | 2013-11-20 | 江景华 | Traditional Chinese medicine preparation for treating traumata and bedsore |
| CN102579651A (en) * | 2012-03-19 | 2012-07-18 | 江景华 | Traditional Chinese medicine preparation for treating traumata and bedsore |
| CN102614355A (en) * | 2012-03-27 | 2012-08-01 | 孙静 | Drug composition for treating bedsores |
| CN102614355B (en) * | 2012-03-27 | 2013-07-24 | 孙静 | Drug composition for treating bedsores |
| CN102698044A (en) * | 2012-06-12 | 2012-10-03 | 唐山职业技术学院 | Preparation method of medicinal composition for treating acne |
| CN102698044B (en) * | 2012-06-12 | 2013-12-04 | 唐山职业技术学院 | Preparation method of medicinal composition for treating acne |
| CN114432378A (en) * | 2021-11-17 | 2022-05-06 | 上海市浦东新区六灶社区卫生服务中心 | Traditional Chinese medicine preparation for treating soft tissue injury and preparation method thereof |
| CN114949065A (en) * | 2022-06-06 | 2022-08-30 | 肇庆市中医院 | Traditional Chinese medicine application for treating early traumatic injury and preparation method thereof |
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