CN103920073B - A kind of chitosan reproductive tract biological antibiotic liquid and preparation method thereof - Google Patents
A kind of chitosan reproductive tract biological antibiotic liquid and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to chitosan reproductive tract biological antibiotic liquid technical field, be specifically related to a kind of chitosan reproductive tract biological antibiotic liquid and preparation method thereof, often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material: modification of chitosan 10-35g, glycerol 5-50g, menthol 0.1-1.5g, Alumen 1.0-1.8g, plant extract 0.5-6g, pH adjusting agent 0-0.1g, purified water surplus, the present invention adopts modification of chitosan, glycerol and containing multiple antiinflammatory, the plant extract of antimicrobial component produces chitosan reproductive tract biological antibiotic liquid, each raw material complements each other, play the synergism between raw material, bacteriostasis property of the present invention is made to reach the best, short treating period, instant effect, be applicable to postoperative disinfection nursing of peritomizing, male's balanitis, acrobystitis, scrotitis etc.The daily private parts nursing of male, the treatment of the diseases such as the cleaning-nursing before and after sexual life and women's cervicitis, vaginitis.
Description
Technical field
The present invention relates to biological antibiotic liquid technical field, be specifically related to a kind of chitosan reproductive tract biological antibiotic liquid and preparation method thereof.
Background technology
Traditional mostly is Chinese medicine or antibiotics antibacterial for the antibacterial care formulations of reproductive tract, nurses the improper protection easily causing that sb.'s illness took a turn for the worse and be difficult to treating or destroy human body itself and have by oneself.
At present, reproductive tract antimicrobial fluid on market is a feast for the eyes, Patent data also has introduces bacteriostatic, the Chinese invention patent application being 200510032571.4 as application number describes a kind of antimicrobial lotion and the preparation method that can kill sperm and virus, it is raw material with Octoxinol (0-9), trichlorine alkyl diphenyl ether, Fructus Cnidii etc., the transparent cream liquid of the colorless and odorless refined with certain technique, aqueous fusion property.
But above antimicrobial lotion fungistatic effect is poor, and can not effectively treat men and women's genital diseases.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of chitosan reproductive tract biological antibiotic liquid of good antimicrobial effect is provided.
To achieve these goals, the present invention adopts following technical scheme: a kind of chitosan reproductive tract biological antibiotic liquid, and often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 10-35g
Glycerol 5-50 g
Menthol 0.1-1.5g
Alumen 1.0-1.8g
Plant extract 0.5-6g
PH adjusting agent 0-0.1g
Purified water surplus.
Often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 10-25g
Glycerol 10-30 g
Menthol 0.1-1.0g
Alumen 1.0-1.3g
Plant extract 2-5g
PH adjusting agent 0-0.1g
Purified water surplus.
Preferably, the one in described modification of chitosan to be deacetylation the be chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
Described pH adjusting agent to be mass concentration be 30% sodium hydroxide solution or mass concentration be the hydrochloric acid solution of 37%.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 10-30 part
Radix Pulsatillae 20-40 part
Herba Euphorbiae Humifusae 10-30 part
Clematis kerriana Drumm. Et Craiab 20-40 part
Radix Scutellariae 20-30 part
Rhizoma Cyperi 10-30 part
Rhizoma Smilacis Glabrae 15-25 part
Semen Momordicae 10-30 part
Folium Artemisiae Argyi 20-30 part
Cortex Dictamni 10-25 part
Radix Sophorae Flavescentis 10-30 part
Fructus Cnidii 10-25 part
Medulla Tetrapanacis 20-30 part.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 10-20 part
Radix Pulsatillae 20-30 part
Herba Euphorbiae Humifusae 10-20 part
Clematis kerriana Drumm. Et Craiab 20-30 part
Radix Scutellariae 20-35 part
Rhizoma Cyperi 10-25 part
Rhizoma Smilacis Glabrae 15-20 part
Semen Momordicae 10-20 part
Folium Artemisiae Argyi 20-25 part
Cortex Dictamni 10-20 part
Radix Sophorae Flavescentis 10-20 part
Fructus Cnidii 10-20 part
Medulla Tetrapanacis 20-25 part.
Modification of chitosan of the present invention belongs to high polycation, and its active group is positively charged, bacterial adsorption can be sticked together, stop it to spread, after attracts bacteria, destroy the cell membrane of antibacterial, cause intracytoplasmic DNA and RNA to flow out, thus reach the effect of kill bacteria.The acidic materials that cation can also produce with bacterium surface simultaneously, as interactions such as lipopolysaccharide, techoic acid, teichuronic acid, capsular polysaccharides, form complicated polyelectrolyte, thus the cell membrane function of antibacterial is got muddled, death.
The bacteriostatic activity of chitosan hydrochlorate of the present invention comparatively chitosan is significantly increased, for the preparation of excellent when wound, hemostasis; Carboxymethyl chitosan of the present invention has anti-infectious function, chitosan has protonated ammonium, protonated ammonium and the electronegative cell membrane effect of antibacterial, absorption and coagulation antibacterial, simultaneously penetration cell wall enters in cell, upsets the metabolism of antibacterial and synthesis and has antibacterial action.The preferred micromolecular carboxymethyl chitosan of the present invention.
Alumen of the present invention has antibacterial action and arresting collape syndrome by astringents effect.
Menthol of the present invention has inhibitory action to herpes simplex virus, forest virus, mumps virus, has bacteriostasis to staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc.; Menthol external, the cold receptor of the tip that can excite nerve and produce creeping chill, and reflexive cause the change of deep tissue blood vessel and play antiinflammatory, pain relieving, antipruritic effect.
Glycerol of the present invention has lubrication, and the dosage form of formation has toughness and protectiveness, makes to have soapy feeling, and can keep longer wetting time as wetting agent, sliding capability is good, can extend actor at mucosa local efficacy, have good lubricant effect; Can be used as hygroscopic agent, viscosity modifier and solvent.
Multiple antiinflammatory, antibacterial, analgesic composition is rich in plant extract of the present invention.
Caulis Lonicerae, sweet, cold.Attach to the lung and stomach meridians, heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain." detailed outline ": " control all rheumatism gas and allly to swell and ache, carbuncle scabies moss, Fructus Myricae rubrae malignant boil, heat radiation removing toxic substances.”
The Radix Pulsatillae, bitter in the mouth, cold in nature; Return stomach, large intestine channel, there is heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, effect of removing dampness and killing parasites.
Herba Euphorbiae Humifusae, pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.Can heat-clearing and toxic substances removing; Dampness removing jaundice eliminating; Promoting blood circulation and hemostasis.Main dysentery, have loose bowels, jaundice; Hemoptysis; Spit blood; Hematuria; Have blood in stool; Metrorrhagia; Agalactia; Treating swelling and pain by traumatic injury and pathopyretic ulcer etc.
Clematis kerriana Drumm. Et Craiab, certain kind of berries leaf Radix clematidis floridae, woody climber.Heat-clearing and toxic substances removing; Diuresis; Eliminating blood stasis and smoothing collaterals.Main carbuncle sore furuncle and phyma; Mastitis; Edema; Dysuria; The difficulty in urination; Traumatic injury
Radix Scutellariae has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions, and in clinical practice, the antibiotic property of Radix Scutellariae is not worse than Rhizoma Coptidis, and does not develop immunity to drugs.
Rhizoma Cyperi, pungent micro-hardship is sweet, flat, resolving depression of regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Rhizoma Smilacis Glabrae has dehumidifying, removing toxic substances, effect of easing joint movement.For damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies, syphilis and the limbs contracture caused by mercurialism, bones and muscles pain.
Semen Momordicae has dispersing swelling and dissipating binds, effect of toxic removing.For controlling carbuncle, furuncle, scrofula, hemorrhoid, innominate toxic swelling, tinea skin ulcer, rheumatic arthralgia, the contracture of muscle arteries and veins.
Folium Artemisiae Argyi is regulated the flow of vital energy blood, by cold-damp; Warming the meridian, hemostasis, antiabortive.Dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus, decortication.
Cortex Dictamni has heat clearing and damp drying, the effect of removing toxic substances of dispeling the wind." property of medicine opinion ": " control all pyretic toxicity wind, aversion to wind, wind skin ulcer, scabies are red rotten, and eyebrow loss of hairs is crisp, and musculus cutaneus is anxious, and high fever aversion to cold, to multiple pathomycete as trichophyton, Trichophyton concentricunm, oidium schoenleinii, all has inhibitory action in various degree.
Radix Sophorae Flavescentis has heat clearing and damp drying, parasite killing, effect of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Antibacterial action: Radix Sophorae Flavescentis ether extract and ethanol extract have stronger bacteriostasis to staphylococcus aureus; Radix Sophorae Flavescentis water logging agent has inhibitory action to trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly difficult to understand little spore tinea bacterium etc.
Fructus Cnidii, removing toxic substances parasite killing dampness is dispeled the wind.External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis, eczema scabies, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago, impotence due to deficiency of the kidney, cold womb are infertile.
Medulla Tetrapanacis, sweet in the mouth; Light; Cold nature.Clear wet diuretic; Lactogenesis.The puckery pain of main stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.
Another object of the present invention is to provide a kind of preparation method of chitosan reproductive tract biological antibiotic liquid, and it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of above-mentioned formula ratio, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis are added purified water and refine, crosses leaching filtrate, concentrated, dry, obtain plant extract;
Step B, weighing: weigh the modification of chitosan of above-mentioned formula ratio, glycerol and plant extract;
Step C, preparation: load weighted for step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and adds purified water and dissolve rear mixing respectively, obtained mixed liquor;
Step D, filtration: the mixed liquor that step C prepares is added purified water and is settled to 1L, stir, after filtering, sterilizing obtains chitosan reproductive tract biological antibiotic liquid.
In described steps A the addition of purified water be Clematis kerriana Drumm. Et Craiab, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis cumulative volume 10-15 doubly, the temperature of refinement is 95-98 DEG C, and the time of refinement is 2-4h.
Control ph is carried out between 4.5-8 by pH adjusting agent in described step D.
Compared with prior art, beneficial effect is in the present invention:
(1) the present invention adopts modification of chitosan, glycerol and the plant extract containing multiple antiinflammatory, antimicrobial component to produce chitosan reproductive tract biological antibiotic liquid, each raw material complements each other, play the synergism between raw material, make bacteriostasis property of the present invention reach the best, short treating period, instant effect.
(2) chitosan reproductive tract biological antibiotic liquid biocompatibility of the present invention meets GB/T 16886.11-2011 requirement.
(3) the present invention is applicable to postoperative disinfection nursing of peritomizing, male's balanitis, acrobystitis, scrotitis etc.The daily private parts nursing of male, the treatment of the diseases such as the cleaning-nursing before and after sexual life and women's cervicitis, vaginitis.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.
embodiment 1.
A kind of chitosan reproductive tract biological antibiotic liquid, often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 10g
Glycerol 5g
Menthol 1.5g
Alumen 1.0g
Plant extract 0.5g
Purified water surplus.
Described modification of chitosan to be deacetylation be 70% chitosan hydrochlorate.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 10 parts
The Radix Pulsatillae 20 parts
Herba Euphorbiae Humifusae 10 parts
Clematis kerriana Drumm. Et Craiab 40 parts
Radix Scutellariae 30 parts
Rhizoma Cyperi 30 parts
Rhizoma Smilacis Glabrae 25 parts
Semen Momordicae 30 parts
Folium Artemisiae Argyi 30 parts
Cortex Dictamni 25 parts
Radix Sophorae Flavescentis 30 parts
Fructus Cnidii 25 parts
Medulla Tetrapanacis 30 parts.
A preparation method for chitosan reproductive tract biological antibiotic liquid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of above-mentioned formula ratio, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis are added purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water be Clematis kerriana Drumm. Et Craiab, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, 10 times of Medulla Tetrapanacis cumulative volume, the temperature of refining is 95 DEG C, and the time of refinement is 4h;
Step B, weighing: weigh the modification of chitosan of above-mentioned formula ratio, glycerol and plant extract;
Step C, preparation: load weighted for step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and adds purified water and dissolve rear mixing respectively, obtained mixed liquor;
Step D, filtration: the mixed liquor that step C prepares is added purified water and is settled to 1L, pH value is 6, stirs, after filtering, sterilizing obtains chitosan reproductive tract biological antibiotic liquid.
embodiment 2.
A kind of chitosan reproductive tract biological antibiotic liquid, often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 15g
Glycerol 15 g
Menthol 1g
Alumen 1.2g
Plant extract 2g
PH adjusting agent 0.05g
Purified water surplus.
Described modification of chitosan to be deacetylation be 95% chitosan hydrochlorate.
Described pH adjusting agent to be mass concentration be 30% sodium hydroxide solution.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 20 parts
The Radix Pulsatillae 25 parts
Herba Euphorbiae Humifusae 18 parts
Clematis kerriana Drumm. Et Craiab 28 parts
Radix Scutellariae 25 parts
Rhizoma Cyperi 23 parts
Rhizoma Smilacis Glabrae 22 parts
Semen Momordicae 22 parts
Folium Artemisiae Argyi 25 parts
Cortex Dictamni 23 parts
Radix Sophorae Flavescentis 25 parts
Fructus Cnidii 19 parts
Medulla Tetrapanacis 23 parts.
A preparation method for chitosan reproductive tract biological antibiotic liquid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of above-mentioned formula ratio, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis are added purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water be Clematis kerriana Drumm. Et Craiab, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, 12 times of Medulla Tetrapanacis cumulative volume, the temperature of refining is 97 DEG C, and the time of refinement is 3h;
Step B, weighing: weigh the modification of chitosan of above-mentioned formula ratio, glycerol and plant extract;
Step C, preparation: load weighted for step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and adds purified water and dissolve rear mixing respectively, obtained mixed liquor;
Step D, filtration: the mixed liquor that step C prepares is added purified water and is settled to 1L, stirs, after filtering, sterilizing obtains chitosan reproductive tract biological antibiotic liquid, add in this step mass concentration be 30% sodium hydroxide solution control ph be 7.
embodiment 3.
A kind of chitosan reproductive tract biological antibiotic liquid, often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 30g
Glycerol 40 g
Menthol 1.1g
Alumen 1.5g
Plant extract 5g
PH adjusting agent 0.01g
Purified water surplus.
Described modification of chitosan to be carboxylation degree be 80% carboxymethyl chitosan.
Described pH adjusting agent to be mass concentration be 37% hydrochloric acid solution.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 25 parts
The Radix Pulsatillae 35 parts
Herba Euphorbiae Humifusae 25 parts
Clematis kerriana Drumm. Et Craiab 35 parts
Radix Scutellariae 26 parts
Rhizoma Cyperi 27 parts
Rhizoma Smilacis Glabrae 22 parts
Semen Momordicae 19 parts
Folium Artemisiae Argyi 26 parts
Cortex Dictamni 19 parts
Radix Sophorae Flavescentis 21 parts
Fructus Cnidii 22 parts
Medulla Tetrapanacis 26 parts.
A preparation method for chitosan reproductive tract biological antibiotic liquid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of above-mentioned formula ratio, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis are added purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water be Clematis kerriana Drumm. Et Craiab, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, 14 times of Medulla Tetrapanacis cumulative volume, the temperature of refining is 96 DEG C, and the time of refinement is 3h;
Step B, weighing: weigh the modification of chitosan of above-mentioned formula ratio, glycerol and plant extract;
Step C, preparation: load weighted for step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and adds purified water and dissolve rear mixing respectively, obtained mixed liquor;
Step D, filtration: the mixed liquor that step C prepares is added purified water and is settled to 1L, stirs, after filtering, sterilizing obtains chitosan reproductive tract biological antibiotic liquid, add in this step mass concentration be 37% hydrochloric acid solution 0.01g control ph be 6.5.
embodiment 4.
A kind of chitosan reproductive tract biological antibiotic liquid, often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 35g
Glycerol 50 g
Menthol 0.1g
Alumen 1.8g
Plant extract 6g
Purified water surplus.
Described modification of chitosan to be carboxylation degree be 90% carboxymethyl chitosan.
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 30 parts
The Radix Pulsatillae 40 parts
Herba Euphorbiae Humifusae 30 parts
Clematis kerriana Drumm. Et Craiab 20 parts
Radix Scutellariae 20 parts
Rhizoma Cyperi 10 parts
Rhizoma Smilacis Glabrae 15 parts
Semen Momordicae 10 parts
Folium Artemisiae Argyi 20 parts
Cortex Dictamni 10 parts
Radix Sophorae Flavescentis 10 parts
Fructus Cnidii 10 parts
Medulla Tetrapanacis 20 parts.
A preparation method for chitosan reproductive tract biological antibiotic liquid, it comprises following preparation process:
The preparation of steps A, plant extract: the Clematis kerriana Drumm. Et Craiab of above-mentioned formula ratio, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, Medulla Tetrapanacis are added purified water and refine, cross leaching filtrate, concentrated, dry, obtain plant extract, the addition of purified water be Clematis kerriana Drumm. Et Craiab, Radix Scutellariae, Rhizoma Cyperi, Rhizoma Smilacis Glabrae, Semen Momordicae, Folium Artemisiae Argyi, Cortex Dictamni, Fructus Cnidii, 15 times of Medulla Tetrapanacis cumulative volume, the temperature of refining is 98 DEG C, and the time of refinement is 2h;
Step B, weighing: weigh the modification of chitosan of above-mentioned formula ratio, glycerol and plant extract;
Step C, preparation: load weighted for step B modification of chitosan, glycerol, Alumen, menthol and plant extract are put and adds purified water and dissolve rear mixing respectively, obtained mixed liquor;
Step D, filtration: the mixed liquor that step C prepares is added purified water and is settled to 1L, stir, after filtering, sterilizing obtains chitosan reproductive tract biological antibiotic liquid.
the human clinical data of chitosan reproductive tract biological antibiotic liquid of the present invention
Dongguan gynecological of hospital, carries out in follow-up investigation to adopting in 100 patients of chitosan reproductive tract biological antibiotic liquid of the present invention, and 65 patient's recoveries from illness, in two years without recurrence, 33 patients symptomatic alleviate greatly, and total effective rate of the present invention is up to 98%.
Hospital of Guangxi andrology, carries out in follow-up investigation to adopting in 200 patients of chitosan reproductive tract biological antibiotic liquid of the present invention, and 140 patient's recoveries from illness, in two years without recurrence, 56 patients symptomatic alleviate greatly, and total effective rate of the present invention is up to 98%.
concrete checking example 1.
Wu, man, 46 years old, scrotitis, when just starting, is edge clear, the erythema of swelling a little, gradually expand, there is squama above, consciously to itch, gradually transfer aubergine, brown or the colour of skin to by redness, adopt the chitosan reproductive tract biological antibiotic liquid of the embodiment of the present invention 1, clean with chitosan reproductive tract biological antibiotic liquid just before going to bed every night, fully recover after two months, do not recur in 4 years.
concrete checking example 2.
Xue, female, 30 years old, leucorrhoea grow in quantity after the raw son of pregnancy, she selects some washing liquids and gel, but always there are no any curative effect, the chitosan reproductive tract biological antibiotic liquid of the rear employing embodiment of the present invention 2, clean with chitosan reproductive tract biological antibiotic liquid every night, after 10 days, leucorrhoea grow in quantity phenomenon disappears, and does not recur in 3 years.
concrete checking example 3.
What certain, man, 37 years old, ring-type balanitis erosiva, from the beginning of being glans penis and foreskin place erythema, expand gradually, in the form of a ring or polycyclic, finally form shallow table ulcer surface, adopt the chitosan reproductive tract biological antibiotic liquid of the embodiment of the present invention 3, every day cleans twice, and after two weeks, ulcer surface disappears substantially, fully recover after two months, do not recur in two years.
concrete checking example 4.
Wang, man, 26 years old, because not noting health, accumulating foulants in foreskin is made to add bacteriological infection sequela, onset initial stage the lighter, only Glans penis and Inner prepuce flushing, and with scratchiness, there is pain and tenderness afterwards, the chitosan reproductive tract biological antibiotic liquid of the rear employing embodiment of the present invention 4, clean with chitosan reproductive tract biological antibiotic liquid, stop using after two weeks, after one month, remove examination in hospital, symptom all disappears, and does not recur in two years.
Finally should be noted that; above embodiment is only in order to illustrate technical scheme of the present invention; but not limiting the scope of the invention; although done to explain to the present invention with reference to preferred embodiment; those of ordinary skill in the art is to be understood that; can modify to technical scheme of the present invention or equivalent replacement, and not depart from essence and the scope of technical solution of the present invention.
Claims (5)
1. a chitosan reproductive tract biological antibiotic liquid, is characterized in that: often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 10-35g
Glycerol 5-50 g
Menthol 0.1-1.5g
Alumen 1.0-1.8g
Plant extract 0.5-6g
PH adjusting agent 0-0.1g
Purified water surplus,
Described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 10-30 part
Radix Pulsatillae 20-40 part
Herba Euphorbiae Humifusae 10-30 part
Clematis kerriana Drumm. Et Craiab 20-40 part
Radix Scutellariae 20-30 part
Rhizoma Cyperi 10-30 part
Rhizoma Smilacis Glabrae 15-25 part
Semen Momordicae 10-30 part
Folium Artemisiae Argyi 20-30 part
Cortex Dictamni 10-25 part
Radix Sophorae Flavescentis 10-30 part
Fructus Cnidii 10-25 part
Medulla Tetrapanacis 20-30 part.
2. a kind of chitosan reproductive tract biological antibiotic liquid according to claim 1, is characterized in that: often liter of chitosan reproductive tract biological antibiotic liquid is made up of following raw material:
Modification of chitosan 10-25g
Glycerol 10-30 g
Menthol 0.1-1.0g
Alumen 1.0-1.3g
Plant extract 2-5g
PH adjusting agent 0-0.1g
Purified water surplus.
3. a kind of chitosan reproductive tract biological antibiotic liquid according to claim 1, is characterized in that: the one in described modification of chitosan to be deacetylation the be chitosan hydrochlorate of 70-95% and the carboxymethyl chitosan of carboxylation degree >=80%.
4. a kind of chitosan reproductive tract biological antibiotic liquid according to claim 1, is characterized in that: described pH adjusting agent to be mass concentration be 30% sodium hydroxide solution or mass concentration be the hydrochloric acid solution of 37%.
5. a kind of chitosan reproductive tract biological antibiotic liquid according to claim 1, is characterized in that: described plant extract is extracted by the raw material of following weight portion and forms:
Caulis Lonicerae 10-20 part
Radix Pulsatillae 20-30 part
Herba Euphorbiae Humifusae 10-20 part
Clematis kerriana Drumm. Et Craiab 20-30 part
Radix Scutellariae 20-35 part
Rhizoma Cyperi 10-25 part
Rhizoma Smilacis Glabrae 15-20 part
Semen Momordicae 10-20 part
Folium Artemisiae Argyi 20-25 part
Cortex Dictamni 10-20 part
Radix Sophorae Flavescentis 10-20 part
Fructus Cnidii 10-20 part
Medulla Tetrapanacis 20-25 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410152430.5A CN103920073B (en) | 2014-04-16 | 2014-04-16 | A kind of chitosan reproductive tract biological antibiotic liquid and preparation method thereof |
Applications Claiming Priority (1)
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Effective date of registration: 20150925 Address after: 523000, Guangdong City, Dongguan province Sanyuanli community finance business building, two floor, No. 205-208, Dongguan City Da Qing Medical Equipment Co., Ltd. Applicant after: DONGGUAN DA QING MEDICAL DEVICES CO., LTD. Applicant after: Guangxi Xinye Biological Technology Co., Ltd. Address before: 537200, Guigang City, Guiping Changan Industrial Zone Jinlong Industrial District third new first floor, the Guangxi Zhuang Autonomous Region Applicant before: Guangxi Xinye Biological Technology Co., Ltd. |