CN108236715A - Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing - Google Patents
Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing Download PDFInfo
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- CN108236715A CN108236715A CN201810111261.9A CN201810111261A CN108236715A CN 108236715 A CN108236715 A CN 108236715A CN 201810111261 A CN201810111261 A CN 201810111261A CN 108236715 A CN108236715 A CN 108236715A
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- vagina
- whitening
- moisturizing
- private part
- propylene glycol
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- 210000001215 vagina Anatomy 0.000 title claims abstract description 36
- 230000002087 whitening effect Effects 0.000 title claims abstract description 35
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 27
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 63
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241001116389 Aloe Species 0.000 claims abstract description 12
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 12
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 12
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 12
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 12
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 12
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 12
- 150000001413 amino acids Chemical class 0.000 claims abstract description 12
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940116229 borneol Drugs 0.000 claims abstract description 12
- 229960003260 chlorhexidine Drugs 0.000 claims abstract description 12
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 12
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 12
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 12
- 239000000174 gluconic acid Substances 0.000 claims abstract description 12
- 239000003906 humectant Substances 0.000 claims abstract description 12
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 12
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 230000008439 repair process Effects 0.000 claims abstract description 11
- 235000007297 Gaultheria procumbens Nutrition 0.000 claims abstract description 10
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 9
- 229930008380 camphor Natural products 0.000 claims abstract description 9
- 229960000846 camphor Drugs 0.000 claims abstract description 9
- 229940064064 purslane extract Drugs 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 35
- 238000003756 stirring Methods 0.000 claims description 12
- 241000736246 Pyrola Species 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 8
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 4
- 241000219304 Portulacaceae Species 0.000 claims description 4
- 230000032683 aging Effects 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 238000004945 emulsification Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 210000004556 brain Anatomy 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 abstract description 4
- 210000001339 epidermal cell Anatomy 0.000 abstract description 3
- 239000000835 fiber Substances 0.000 abstract description 3
- 210000004400 mucous membrane Anatomy 0.000 abstract description 3
- 210000003097 mucus Anatomy 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract description 3
- 230000003248 secreting effect Effects 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 241000333569 Pyrola minor Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 201000008100 Vaginitis Diseases 0.000 description 3
- 206010046914 Vaginal infection Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 239000009637 wintergreen oil Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 208000032159 Vaginal inflammation Diseases 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Gynecology & Obstetrics (AREA)
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Abstract
The present invention provides a kind of female private parts, whitening antibacterial gel is repaired in vagina moisturizing, including card wave 0.5~0.9%, propylene glycol 8~14%, amino acid humectant 1~4%, gluconic acid chlorhexidine 0.1~0.3%, borneol 0.1~0.3%, camphor 0.1~0.3%, wintergreen 0.1~0.6%, Sodium Hyaluronate 0.2~0.5%, dipotassium glycyrrhizinate 0.15~0.6%, Purslane extract 0.3~0.8%, whitening nonapeptide 0.2~0.8%, essence 0.02~0.06%, CO 40 0.15~0.4%, extract solution from aloe 1~4%, outstanding horse BP 0.06~0.18%, triethanolamine 0.2~0.5%, purify water surplus.Bactericidal effect is notable, irritation is small, does not influence the subenvironment balance of human body natural, it is 3.8 5.0 that pH value is adjusted after disinfection；Microecology in vaginas can be maintained to balance；While the mode of repairing fiber cell, epidermal cell repairs vagina, and vagina recovery is made to compact, mucous membrane restores secreting mucus, moistens moisturizing；There is moisturizing, whitening, compact, antibacterial, it is made to keep good elasticity and vigor.
Description
Technical field
The present invention relates to a kind of female private part articles for use field, specially a kind of female private part, vagina moisturizing are repaired whitening and are resisted
Bacterium gel and its manufacture craft.
Background technology
The vagina of women is the important Tiny ecosystem area of women, and it is to cause gynaecology's episioitis that microecology in vaginas of women is unbalance
The main reason for recurrent exerbation.Improve vaginal microenvironment, maintain microecology in vaginas balance, improve vagina cleanness degree, mention vagina
Mucosal immunity is of great significance for treatment vagina common disease.
Existing vaginal lotion is easily destroyed the weak acid environment of intravaginal, therefore promotion intravaginal that can not be quickly is excellent
The proliferation of gesture bacterium.
Invention content
The technical problem to be solved by the present invention is to overcome the weak acid environment that existing vaginal lotion is easily destroyed intravaginal,
Therefore the defects of proliferation of promotion intravaginal dominant bacteria that can not be quickly, provides a kind of female private part, U.S. is repaired in vagina moisturizing
White antibacterial gel and its manufacture craft.
In order to solve the above technical problem, the present invention provides following technical solutions：
Whitening antibacterial gel is repaired in a kind of female private part, vagina moisturizing, includes each component of following weight percent：
Card wave 0.5~0.9%, propylene glycol 8~14%, amino acid humectant 1~4%, gluconic acid chlorhexidine 0.1~0.3%, borneol
0.1~0.3%, camphor 0.1~0.3%, wintergreen 0.1~0.6%, Sodium Hyaluronate 0.2~0.5%, dipotassium glycyrrhizinate 0.15~
0.6%th, Purslane extract 0.3~0.8%, whitening nonapeptide 0.2~0.8%, essence 0.02~0.06%, CO-40 0.15~
0.4%th, extract solution from aloe 1~4%, outstanding horse BP 0.06~0.18%, triethanolamine 0.2~0.5%, purify water surplus.
Preferably, include each component of following weight percent：
Card wave 0.75%, propylene glycol 10%, amino acid humectant 2%, gluconic acid chlorhexidine 0.2%, borneol 0.2%, 0.2 brain % of camphor tree,
Wintergreen 0.4%, Sodium Hyaluronate 0.35%, dipotassium glycyrrhizinate 0.35%, Purslane extract 0.5%, whitening nonapeptide 0.5%, essence
0.05%th, CO-40 0.25%, extract solution from aloe 2%, outstanding horse BP 0.1%, triethanolamine 0.35%, purify water surplus.
Above-mentioned female private part, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, include the following steps：
1）, purified water adds in agitated kettle, open blender and be added with stirring card wave kilogram, stir to being completely dissolved, add
Propylene glycol is appropriate and amino acid humectant is uniformly mixing to obtain A material；
2）, gluconic acid chlorhexidine and propylene glycol are heated to 35~50 DEG C obtain B material；Preferably 40 DEG C.
3）, will borneol, camphor add in wintergreen in dissolving obtain C material；
4）, Sodium Hyaluronate, add in appropriate propylene glycol, obtain D material；
5）, A expect be pumped into emulsification pot, add in B material, C material and D material, sequentially added after mixing dipotassium glycyrrhizinate, purslane extraction
Liquid, whitening nonapeptide, essence, CO-40, extract solution from aloe, outstanding horse, triethanolamine stir evenly；
6）, ageing 18~26 hours, it is filling after the assay was approved.
4th, the manufacture craft of female private part as claimed in claim 4, vagina moisturizing reparation whitening antibacterial gel, feature
It is, the step 1）Middle speed of agitator is 30~50 turns/min.
5th, the manufacture craft of female private part as claimed in claim 4, vagina moisturizing reparation whitening antibacterial gel, feature
It is, the mass ratio of the dosage of propylene glycol is 3 in A material, B material and D material:1:1.
Whitening antibacterial gel is repaired in the private parts of the present invention, vagina moisturizing, and bactericidal effect is notable, irritation is small, does not influence people
The natural subenvironment balance of body, has both trophism, and stability is good, and it is 3.8-5.0 that pH value is adjusted after disinfection；It can promote newborn bar
Bacterium is proliferated and achievees the purpose that inhibit pathogenic bacteria, increases the absolute number of dominant bacteria lactobacillus, reduces pathogenic bacteria number, remains cloudy
Road microecological balance improves vagina cleanness degree, improves vagina mucosa immunity, reaches prevention gynaecologic vaginal inflammation, reduces gynaecology
Vaginitis recurrence rate, and safety；While the mode of repairing fiber cell, epidermal cell repairs vagina, and vagina recovery is made to compact, is sticked
Film restores secreting mucus, moistens moisturizing；There is moisturizing, whitening, compact, antibacterial, it is thin to the mucous membrane of private parts and intravaginal
Born of the same parents carry out deep layer repair, can supplement skin nutrition, it is made to keep good elasticity and vigor.
Specific embodiment
The preferred embodiment of the present invention is illustrated below, it should be understood that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
Whitening antibacterial gel is repaired in a kind of female private part, vagina moisturizing, includes each component of following weight percent：
Card wave 0.75%, propylene glycol 10%, amino acid humectant 2%, gluconic acid chlorhexidine 0.2%, borneol 0.2%, 0.2 brain % of camphor tree,
Wintergreen 0.4%, Sodium Hyaluronate 0.35%, dipotassium glycyrrhizinate 0.35%, Purslane extract 0.5%, whitening nonapeptide 0.5%, essence
0.05%th, CO-40 0.25%, extract solution from aloe 2%, outstanding horse BP 0.1%, triethanolamine 0.35%, purify water surplus.
Above-mentioned female private part, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, include the following steps：
1）, purified water adds in agitated kettle, open blender and be added with stirring card wave kilogram, stir to being completely dissolved, add
Propylene glycol is appropriate and amino acid humectant is uniformly mixing to obtain A material；
2）, gluconic acid chlorhexidine and propylene glycol are heated to 40 DEG C obtain B material；
3）, will borneol, camphor add in wintergreen in dissolving obtain C material；
4）, Sodium Hyaluronate, add in appropriate propylene glycol, obtain D material；
5）, A expect be pumped into emulsification pot, add in B material, C material and D material, sequentially added after mixing dipotassium glycyrrhizinate, purslane extraction
Liquid, whitening nonapeptide, essence, CO-40, extract solution from aloe, outstanding horse, triethanolamine stir evenly；
6）, ageing 18~26 hours, it is filling after the assay was approved.
Embodiment 2
Whitening antibacterial gel is repaired in a kind of female private part, vagina moisturizing, includes each component of following weight percent：
Card wave 0.5%, propylene glycol 8%, amino acid humectant 1%, gluconic acid chlorhexidine 0.3%, borneol 0.3%, camphor 0.3%, winter
Green oil 0.1%, Sodium Hyaluronate 0.2, dipotassium glycyrrhizinate 0.15%, Purslane extract 0.3%, whitening nonapeptide 0.8%, essence
0.06%th, CO-40 0.15%, extract solution from aloe 1%, outstanding horse BP 0.18%, triethanolamine 0.5%, purify water surplus.
Above-mentioned female private part, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, include the following steps：
1）, purified water adds in agitated kettle, open blender and be added with stirring card wave kilogram, stir to being completely dissolved, add
Propylene glycol is appropriate and amino acid humectant is uniformly mixing to obtain A material；
2）, gluconic acid chlorhexidine and propylene glycol are heated to 50 DEG C obtain B material；
3）, will borneol, camphor add in wintergreen in dissolving obtain C material；
4）, Sodium Hyaluronate, add in appropriate propylene glycol, obtain D material；
5）, A expect be pumped into emulsification pot, add in B material, C material and D material, sequentially added after mixing dipotassium glycyrrhizinate, purslane extraction
Liquid, whitening nonapeptide, essence, CO-40, extract solution from aloe, outstanding horse, triethanolamine stir evenly；
6）, ageing 18~26 hours, it is filling after the assay was approved.
Embodiment 3
Whitening antibacterial gel is repaired in a kind of female private part, vagina moisturizing, includes each component of following weight percent：
Card wave 0.9%, propylene glycol 14%, amino acid humectant 4%, gluconic acid chlorhexidine 0.1%, borneol 0.1%, camphor 0.1%, winter
Green oil 0.6%, Sodium Hyaluronate 0.5%, dipotassium glycyrrhizinate 0.6%, Purslane extract 0.8%, whitening nonapeptide 0.2%, essence
0.02%th, CO-40 0.4%, extract solution from aloe 4%, outstanding horse BP 0.06%, triethanolamine 0.2%, purify water surplus.
The production method of the present embodiment is the same as embodiment 1.
Properties of product are tested
First, skin irritation test
1st, subjects：Healthy adult rabbit 100 is chosen, is divided into 4 groups, every group 25, every rabbit back selects shaving at 4
9cm2。
2nd, test method：The bacteriostatic gel implemented obtained by 1-3 is tried out respectively at the shaving of 25 rabbit, every 8 is small
When smear it is primary, observation for 24 hours, 48h and 72h smear the situation at position.
3rd, result of the test：100 tested rabbit do not occur the local stimulations such as erythema, oedema reaction, illustrate this hair
Bright bacteriostatic gel obtained is safe and non-stimulating, without any adverse reactions.
2nd, clinic trial
1st, object is tried out：100 women clinical bacteria vaginitis triers, age 25-65 Sui.
2nd, application method：Bacteriostatic gel is smeared in skin appointed part；It is primary before sleeping daily.
Pay a return visit trial state.With the gel of 201010132748.9 embodiment 1 of Chinese patent as control
The effective percentage of embodiment 1-3 is respectively 98%, 96%, 96%；The effective percentage of control group is 84%.The treatment week of embodiment 1-3
Phase is 5 days, 7 days and 6 days；And the treatment cycle of control group is 14 days.The recurrence rate of embodiment 1-3 checked after five weeks is respectively
12%th, 18% and 20%, the recurrence rate of control group is 57%.And the bacteriostatic gel of the present invention is coarse to pore, drying peeling, wrinkle
Wait skin problems that there is good improvement result, effective percentage is more than 96.8%.The mode of repairing fiber cell, epidermal cell
Vagina is repaired, vagina recovery is made to compact, mucous membrane restores secreting mucus, moistens moisturizing；With moisturizing, whitening, compact, the work(of antibacterial
Can, deep layer repair is carried out to the mucomembranous cell of private parts and intravaginal, skin nutrition can be supplemented, it is made to keep good bullet
Property and vigor.
Finally it should be noted that：The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify to the technical solution recorded in foregoing embodiments or carry out equivalent replacement to which part technical characteristic.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in the present invention's
Within protection domain.
Claims (6)
1. whitening antibacterial gel is repaired in a kind of female private part, vagina moisturizing, which is characterized in that including each of following weight percent
Component：
Card wave 0.5~0.9%, propylene glycol 8~14%, amino acid humectant 1~4%, gluconic acid chlorhexidine 0.1~0.3%, borneol
0.1~0.3%, camphor 0.1~0.3%, wintergreen 0.1~0.6%, Sodium Hyaluronate 0.2~0.5%, dipotassium glycyrrhizinate 0.15~
0.6%th, Purslane extract 0.3~0.8%, whitening nonapeptide 0.2~0.8%, essence 0.02~0.06%, CO-40 0.15~
0.4%th, extract solution from aloe 1~4%, outstanding horse BP 0.06~0.18%, triethanolamine 0.2~0.5%, purify water surplus.
2. whitening antibacterial gel is repaired in a kind of female private part as described in claim 1, vagina moisturizing, which is characterized in that including
The each component of following weight percent：
Card wave 0.75%, propylene glycol 10%, amino acid humectant 2%, gluconic acid chlorhexidine 0.2%, borneol 0.2%, 0.2 brain % of camphor tree,
Wintergreen 0.4%, Sodium Hyaluronate 0.35%, dipotassium glycyrrhizinate 0.35%, Purslane extract 0.5%, whitening nonapeptide 0.5%, essence
0.05%th, CO-40 0.25%, extract solution from aloe 2%, outstanding horse BP 0.1%, triethanolamine 0.35%, purify water surplus.
3. female private part as claimed in claim 1 or 2, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, feature
It is, includes the following steps：
1）, purified water adds in agitated kettle, open blender and be added with stirring card wave, stir to being completely dissolved, add the third two
Alcohol is appropriate and amino acid humectant is uniformly mixing to obtain A material；
2）, gluconic acid chlorhexidine and propylene glycol are heated to 35~50 DEG C obtain B material；
3）, will borneol, camphor add in wintergreen in dissolving obtain C material；
4）, Sodium Hyaluronate, add in appropriate propylene glycol, obtain D material；
5）, A expect be pumped into emulsification pot, add in B material, C material and D material, sequentially added after mixing dipotassium glycyrrhizinate, purslane extraction
Liquid, whitening nonapeptide, essence, CO-40, extract solution from aloe, outstanding horse, triethanolamine stir evenly；
6）, ageing 18~26 hours, it is filling after the assay was approved.
4. female private part as claimed in claim 4, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, feature exists
In the step 1）Middle speed of agitator is 30~50 turns/min.
5. female private part as claimed in claim 4, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, feature exists
In the mass ratio of the dosage of propylene glycol is 3 in A material, B material and D material:1:1.
6. female private part as claimed in claim 4, vagina moisturizing repair the manufacture craft of whitening antibacterial gel, feature exists
In the heating temperature of B material is 40 DEG C.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810111261.9A CN108236715A (en) | 2018-02-05 | 2018-02-05 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810111261.9A CN108236715A (en) | 2018-02-05 | 2018-02-05 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
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| CN108236715A true CN108236715A (en) | 2018-07-03 |
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| CN201810111261.9A Pending CN108236715A (en) | 2018-02-05 | 2018-02-05 | Whitening antibacterial gel and its manufacture craft are repaired in a kind of female private part, vagina moisturizing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110787109A (en) * | 2019-12-07 | 2020-02-14 | 路书刚 | Preparation containing peptide for repairing and tightening |
| CN111434334A (en) * | 2019-01-11 | 2020-07-21 | 李可 | Female gel |
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