CN107789611A - A kind of collagen peptide lubricating fluid and preparation method thereof - Google Patents
A kind of collagen peptide lubricating fluid and preparation method thereof Download PDFInfo
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- CN107789611A CN107789611A CN201711047941.0A CN201711047941A CN107789611A CN 107789611 A CN107789611 A CN 107789611A CN 201711047941 A CN201711047941 A CN 201711047941A CN 107789611 A CN107789611 A CN 107789611A
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- collagen peptide
- fermented
- lubricating fluid
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- 102000008186 Collagen Human genes 0.000 title claims abstract description 105
- 108010035532 Collagen Proteins 0.000 title claims abstract description 105
- 229920001436 collagen Polymers 0.000 title claims abstract description 105
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 86
- 230000001050 lubricating effect Effects 0.000 title claims abstract description 50
- 239000012530 fluid Substances 0.000 title claims abstract description 49
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 93
- 238000000855 fermentation Methods 0.000 claims abstract description 88
- 230000004151 fermentation Effects 0.000 claims abstract description 88
- 235000019225 fermented tea Nutrition 0.000 claims abstract description 82
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 79
- 235000018597 common camellia Nutrition 0.000 claims abstract description 64
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 64
- 240000001548 Camellia japonica Species 0.000 claims abstract description 63
- 240000006914 Aspalathus linearis Species 0.000 claims abstract description 52
- 235000012984 Aspalathus linearis Nutrition 0.000 claims abstract description 52
- 241000233866 Fungi Species 0.000 claims abstract description 50
- 239000012528 membrane Substances 0.000 claims abstract description 50
- 239000008367 deionised water Substances 0.000 claims abstract description 48
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 48
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims abstract description 40
- DTTVNCZEOYSFFF-UHFFFAOYSA-N ethoxyurea Chemical compound CCONC(N)=O DTTVNCZEOYSFFF-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000019198 oils Nutrition 0.000 claims abstract description 28
- 240000007436 Cananga odorata Species 0.000 claims abstract description 24
- 235000007571 Cananga odorata Nutrition 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 21
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 21
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 21
- 229940051250 hexylene glycol Drugs 0.000 claims abstract description 20
- 239000000243 solution Substances 0.000 claims description 101
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 78
- 238000003756 stirring Methods 0.000 claims description 54
- 238000006243 chemical reaction Methods 0.000 claims description 44
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 42
- 244000269722 Thea sinensis Species 0.000 claims description 36
- 230000001954 sterilising effect Effects 0.000 claims description 32
- 235000006468 Thea sinensis Nutrition 0.000 claims description 31
- 235000020279 black tea Nutrition 0.000 claims description 31
- 239000003921 oil Substances 0.000 claims description 27
- 239000007864 aqueous solution Substances 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 22
- 238000010792 warming Methods 0.000 claims description 22
- 239000011248 coating agent Substances 0.000 claims description 21
- 238000000576 coating method Methods 0.000 claims description 21
- 238000002156 mixing Methods 0.000 claims description 14
- 108091005508 Acid proteases Proteins 0.000 claims description 13
- 230000001580 bacterial effect Effects 0.000 claims description 13
- 230000008901 benefit Effects 0.000 claims description 13
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 13
- 229910000397 disodium phosphate Inorganic materials 0.000 claims description 13
- 235000019800 disodium phosphate Nutrition 0.000 claims description 13
- 239000012153 distilled water Substances 0.000 claims description 13
- 235000021552 granulated sugar Nutrition 0.000 claims description 13
- 239000001488 sodium phosphate Substances 0.000 claims description 13
- KJESGYZFVCIMDE-UHFFFAOYSA-N 1-chloroethanol Chemical compound CC(O)Cl KJESGYZFVCIMDE-UHFFFAOYSA-N 0.000 claims description 12
- 102000004190 Enzymes Human genes 0.000 claims description 12
- 108090000790 Enzymes Proteins 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical class [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- 241000234435 Lilium Species 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 11
- 230000009849 deactivation Effects 0.000 claims description 11
- 238000000502 dialysis Methods 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 230000035484 reaction time Effects 0.000 claims description 11
- 238000010992 reflux Methods 0.000 claims description 11
- 238000009288 screen filtration Methods 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 11
- 238000010129 solution processing Methods 0.000 claims description 10
- 238000004659 sterilization and disinfection Methods 0.000 claims description 10
- 238000001291 vacuum drying Methods 0.000 claims description 9
- 239000006228 supernatant Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004202 carbamide Substances 0.000 claims description 6
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 241001375216 Picria Species 0.000 claims description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 4
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims description 2
- 235000003097 Artemisia absinthium Nutrition 0.000 claims description 2
- 240000001851 Artemisia dracunculus Species 0.000 claims description 2
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims description 2
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 2
- 239000001138 artemisia absinthium Substances 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- 241000209507 Camellia Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 239000004833 fish glue Substances 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 239000000314 lubricant Substances 0.000 abstract description 8
- 230000007774 longterm Effects 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 description 44
- 241000894006 Bacteria Species 0.000 description 17
- 210000003739 neck Anatomy 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 6
- 235000013616 tea Nutrition 0.000 description 6
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 3
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 3
- 229940092714 benzenesulfonic acid Drugs 0.000 description 3
- 239000010495 camellia oil Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 210000001215 vagina Anatomy 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 208000028990 Skin injury Diseases 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 2
- 230000001139 anti-pruritic effect Effects 0.000 description 2
- 239000003908 antipruritic agent Substances 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- BFSPAPKTIGPYOV-BQYQJAHWSA-N (e)-1-[4-(4-hydroxyphenyl)piperazin-1-yl]-3-thiophen-2-ylprop-2-en-1-one Chemical compound C1=CC(O)=CC=C1N1CCN(C(=O)\C=C\C=2SC=CC=2)CC1 BFSPAPKTIGPYOV-BQYQJAHWSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000186779 Listeria monocytogenes Species 0.000 description 1
- 229920001046 Nanocellulose Polymers 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000589540 Pseudomonas fluorescens Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000008104 plant cellulose Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of collagen peptide lubricating fluid and preparation method thereof, it is made up of following raw material：60 80 parts of 5 20 parts of red tea fungus fermented date liquid, 0.5 1.2 parts of sodium hyaluronate, 12 parts of fermented tea fermentation membrane modifying thing, 8 12 parts of collagen peptide, 0.3 0.5 parts of Cananga odorata quintessence oil, 35 parts of water-soluble camellia seed oil, 0.5 1 parts of ethoxy urea, 0.5 1 parts of hexylene glycol and deionized water.The collagen peptide lubricating fluid of the present invention makes for natural plants and formed, and not only carries, be easy to use, and can effectively clean, improve heat effect, is a kind of lubricant product that can be long-term use of.
Description
Technical field
The present invention relates to a kind of collagen peptide lubricating fluid and preparation method thereof, belong to the technical field of washing product.
Background technology
Human body lubricants are to be different from mechanical use, specifically for the lubricant of human design, have wide applicability and
Higher security.A good human body lubricants singly be not increase lubricant effect, promote voluptus, allow sexual life more and
It is humorous, promote emotion between husband and wife；Skin injury is more reduced simultaneously, reduces the harmful microorganisms such as bacterium, virus to human body
Erosion chance；The breakage of condom is effectively reduced, reduces the probability of accidental pregnancy.
Lubricant is applied also very long history in human sexuality, and only early stage people use vegetable fat such as
Olive oil etc..But by composition, to limit effect unsatisfactory, easily pollutes clothes, is also not easy to be absorbed by the body；Later people
Also attempt to use the petroleum-based mineral oily matter such as vaseline, baby oil, body lotion, massage oil as lubrication；These materials are past
Past viscosity is excessive, not easy cleaning.Residual is easily caused after use, is likely to block men and women's urethra even with after
Mouthful, dysuria pain is produced, and the stability of condom can be destroyed, cause unexpectedly to be pregnant, these can all make human body
Into infringement.
The content of the invention
In order to solve the above mentioned problem present in prior art, present invention offer is a kind of can be effectively improved vaginal dryness
Collagen peptide lubricating fluid, formed for natural products fermentation, have and carry, be easy to use, and can effectively clean, improvement property
Excitatory effects, it is a kind of lubricant product that can be long-term use of, while there is the effect of good anti-inflammation and sterilization is antipruritic.
Technical scheme is as follows：
A kind of collagen peptide lubricating fluid, is made up of following raw material：Red tea fungus fermented date liquid 5-20 parts, sodium hyaluronate 0.5-
1.2 parts, fermented tea fermentation membrane modifying thing 0.2-2 parts, collagen peptide 8-15 parts, Cananga odorata quintessence oil 0.3-0.5 parts, water-soluble oil tea
Seed oil 3-5 parts, ethoxy urea 0.5-1 parts, hexylene glycol 0.5-1 parts and deionized water 60-80 parts.
Further, red tea fungus fermented date liquid 10-18 parts, sodium hyaluronate 0.75-1 parts, fermented tea fermentation membrane modifying thing 0.5-1.5
Part, collagen peptide 8-12 parts, Cananga odorata quintessence oil 0.35-0.5 parts, water-soluble camellia seed oil 4-5 parts, ethoxy urea 0.75-1
Part, hexylene glycol 0.75-1 parts and deionized water 65-70 parts.
Further, the red tea fungus fermented date liquid is made up of following raw material：Black tea 4-9 parts, picria fel tarrae 8-12 parts,
Wormwood 2-6 parts, white granulated sugar 45-55 parts, deionized water 900-1200 parts and black tea mother bacterial liquid 45-60 parts.
Further, the fermented tea fermentation membrane modifying thing is made up of following raw material：Mass concentration is 1.5-3%
100 parts of coating solution of fermented tea fermentation, chlorethanol 20-35 parts and acetic acid 2-10 parts；The fermented tea ferments coating solution by following
Raw material is made：The NaOH and mass concentration that mass concentration is 5% be 6% ethoxy urea mixed aqueous solution 90-110 parts and
Fermented tea fermentation film 1-3 parts.
Further, the water-soluble camellia seed oil is made up of following raw material：100 parts of Natrulon H-10, saturation
Disodium phosphate soln 1-2 parts, camellia seed oil 12-20 parts, 2 parts of p-methyl benzenesulfonic acid and saturated sodium bicarbonate solution 1-3 parts.
Further, the collagen peptide is made up of following raw material：100 parts of fish-skin of drying, mass concentration are
0.4% NaOH and mass concentration is 0.6% H2SO4300 parts of mixed aqueous solution, 100 parts of distilled water, the pancreas that concentration is 40U/mL
Protease 1-8 parts and acid protease 3-7 parts that mass concentration is 2%.
Present invention additionally comprises with a kind of preparation method of collagen peptide lubricating fluid, comprise the following steps：（1）Under normal temperature,
0.2-2 parts by weight fermented tea fermentation membrane modifying thing and 8-15 parts by weight collagen peptide is molten with 60-80 parts by weight of deionized water
Solution；（2）The sodium hyaluronate of 0.5-1.2 parts by weight is added, is warming up to 60 DEG C, stirring makes it dissolve and be well mixed；（3）Temperature is kept
60 DEG C, 0.5-1 parts by weight hexylene glycol and 0.5-1 parts by weight ethoxy urea are added, stirring makes it dissolve and be well mixed；（4）
Room temperature is cooled to, sequentially adds 3-5 parts by weight water-soluble camellia seed oil and 5-20 parts by weight red tea fungus fermented date liquids, is well mixed；
（5）0.3-0.5 parts by weight Cananga odorata quintessence oils are added, is well mixed, produces lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 4-9 parts by weight, 8-12 parts by weight
Picria fel tarrae, the lily of 2-6 parts by weight, the deionized water of the white granulated sugar of 45-55 parts by weight and 900-1200 parts by weight mix
100-120min is boiled in conjunction, stands cooled and filtered, deionized water is added in filtrate, filtrate is kept 900-1200 weight
Part, mix and add in container, be put into the overweight sterilizing 20min of high-temperature sterilization, sterilizing is cooled to room temperature after terminating, add 45-60 weights
The black tea mother bacterial liquid of part is measured, is sealed with gauze, after fermenting 7 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the matter of 90-110 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that amount concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
The fermented tea fermentation film of 1-3 parts by weight is rapidly added before knot, quickly stirs 5min at room temperature, then placed under the conditions of -7 DEG C
20min, obtain the fermented tea fermentation coating solution that mass concentration is 1.5-3%；（3）It is 1.5-3%'s in 100 parts by weight mass concentrations
The chlorethanol of 20-35 parts by weight is added in fermented tea fermentation coating solution, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds
Enter acetic acid and be neutralized to neutral stopping reaction；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）
Supernatant liquor is collected, fermented tea fermentation membrane modifying thing is obtained in vacuum drying.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 1-2 parts by weight are added；（2）In 60 DEG C of conditions
Lower carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 12-20 parts by weight is first added dropwise, adds 2 parts by weight
P-methyl benzenesulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）Liquid
It is transferred to after cooling in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend and handled for 0.6% H2SO4 mixed aqueous solutions, then be washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 1-8 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 3-7 weights
It is 2% acid protease to measure part mass concentration, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation,
Both collagen peptide extract solution is obtained, then powder is obtained after being freeze-dried.
The present invention has the advantages that
It with the addition of red tea fungus fermented date liquid in product, abundant Tea Polyphenols, small-molecular peptides, acetic acid and resistance to contained in red tea fungus fermented date liquid
The antibacterial substances such as hot protein, polysaccharide, to Escherichia coli, Bacterium enteritidis, shigella dysenteriae, Listeria monocytogenes,
The common pathogen such as Pseudomonas fluorescens and staphylococcus aureus has good inhibiting effect, and not resistance to such bacterium
The property of medicine, while product does not add artificial preservative, product has the biology of good antisepsis, composition and human skin in itself
Compatibility is fine, in the absence of the uncomfortable effect of allergy, stimulation etc..Product has the effect of repair cell, protection mucous membrane simultaneously.
Fermented tea fermentation membrane modifying thing is added in product simultaneously, fermented tea fermentation film is natural as caused by fermenting fermented tea
Cellulose, it has the chemical composition as plant cellulose, belongs to typical biological nano cellulose, have high water holding
The features such as property, high-tensile., will and fermented tea fermentation membrane modifying thing is modified on the basis of fermented tea ferments film
Fermented tea fermentation film in cellulose polysaccharide, it is protein-modified for small-molecular peptides, oligosaccharides isoreactivity material, not only remain its guarantor
Water characteristic, and modified small molecule bioactive material can be combined with the vagina skin of women well, be had to it
Beauty, anti-relaxation, increase the effect of elastic.
Water-soluble camellia seed oil is with the addition of in product, camellia seed oil contains vitamin E and antioxidant content, therefore it can be protected
Sheath skin, skin injury and aging can be especially prevented, make skin that there is gloss, and water-soluble camellia seed oil is in tea seed oil
On the basis of be modified, camellia seed oil not soluble in water is modified as being dissolved in the water, so that camellia seed oil can be with profit
Other compositions in synovia are coordinated, and the beauty to vagina skin for increasing lubricating fluid resists anti-relaxation, increase vagina bullet
The effect of property.
The fermented tea fermentation lubricating fluid of the present invention not only carries, is easy to use, and can effectively clean, improve heat
Effect, it is a kind of lubricant product that can be long-term use of.Vaginal dryness problem caused by can solve the problem that the reasons such as climacteric, not only
Can effectively lubricating, and with antipruritic anti-inflammatory effect.
It is easy to get with raw material, the advantages that easily operated, reaction condition is gentle, positive effect, and cost is cheap.
Embodiment
With reference to specific embodiment, the present invention will be described in detail.
Embodiment 1
A kind of collagen peptide lubricating fluid, is made up of following raw material：15 parts of red tea fungus fermented date liquid, 0.75 part of sodium hyaluronate,
0.5 part of fermented tea fermentation membrane modifying thing, 10 parts of collagen peptide, 0.35 part of Cananga odorata quintessence oil, 3.5 parts of water-soluble camellia seed oil, hydroxyl
68.4 parts of 0.75 part of ethyl urea, 0.75 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 0.5 parts by weight black tea
Bacterium fermentation membrane modifying thing and 10 parts by weight collagen peptides are dissolved with 68.4 parts by weight of deionized water；（2）Add 0.75 parts by weight
Sodium hyaluronate, be warming up to 60 DEG C, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.75 parts by weight oneself two
Alcohol and 0.75 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 3.5 weight
The water-soluble camellia seed oil of part and 15 parts by weight red tea fungus fermented date liquids, are well mixed；（5）0.35 parts by weight Cananga odorata quintessence oil is added, is mixed
Close uniformly, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 4 parts by weight, 8 parts by weight it is bitter profound
100min is boiled in the deionized water mixing of ginseng, the lily of 2 parts by weight, the white granulated sugar of 45 parts by weight and 900 parts by weight, stands
Cooled and filtered, deionized water is added in filtrate, filtrate is kept 900 parts by weight, mixed and add in container, be put into high temperature and go out
The overweight sterilizing 20min of bacterium, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 45 parts by weight, sealed with gauze, normal
After being fermented 7 days under normal temperature and pressure, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）The quality of 95 parts by weight is dense
The mixed aqueous solution spent for 5% NaOH and mass concentration the ethoxy urea for being 6% is cooled to -7 DEG C in advance；（2）Take advantage of before solution do not freeze
The fermented tea fermentation film of 2 parts by weight is rapidly added, quickly stirs 5min at room temperature, then 20min is placed under the conditions of -7 DEG C, is obtained
To the fermented tea fermentation coating solution that mass concentration is 2%；（3）In the fermented tea fermentation coating solution that 100 parts by weight mass concentrations are 2%
The middle chlorethanol for adding 25 parts by weight, 50 DEG C of reaction 2h are warming up to after reacting 2h at room temperature, addition acetic acid is neutralized to neutrality and stopped
Only react；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Collect supernatant liquor, Yu Zhen
Sky is dried to obtain fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 14 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 6 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 4 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 2
A kind of collagen peptide lubricating fluid, is made up of following raw material：17 parts of red tea fungus fermented date liquid, 0.75 part of sodium hyaluronate,
0.75 part of fermented tea fermentation membrane modifying thing, 10 parts of collagen peptide, 0.35 part of Cananga odorata quintessence oil, 4.5 parts of water-soluble camellia seed oil, hydroxyl
65.25 parts of 0.6 part of ethyl urea, 0.8 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）It is under normal temperature, 0.75 parts by weight are red
Tea bacterium fermentation membrane modifying thing and 10 parts by weight collagen peptides are dissolved with 65.25 parts by weight of deionized water；（2）Add 0.75 weight
The sodium hyaluronate of part, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.8 parts by weight oneself
Glycol and 0.6 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 4.5 weights
Part water solubility camellia seed oil and 17 parts by weight red tea fungus fermented date liquids are measured, are well mixed；（5）0.35 parts by weight Cananga odorata quintessence oil is added,
It is well mixed, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 5 parts by weight, the hardship of 10 parts by weight
110min is boiled in the deionized water mixing of radix scrophulariae, the lily of 4 parts by weight, the white granulated sugar of 50 parts by weight and 1000 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1000 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 50 parts by weight, sealed with gauze
Mouthful, after fermenting 7 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）The quality of 95 parts by weight is dense
The mixed aqueous solution spent for 5% NaOH and mass concentration the ethoxy urea for being 6% is cooled to -7 DEG C in advance；（2）Take advantage of before solution do not freeze
The fermented tea fermentation film of 1.5 parts by weight is rapidly added, quickly stirs 5min at room temperature, then 20min is placed under the conditions of -7 DEG C,
Obtain the fermented tea fermentation coating solution that mass concentration is 1.5-3%；（3）Sent out in the fermented tea that 100 parts by weight mass concentrations are 1.5%
The chlorethanol of 20 parts by weight is added in ferment coating solution, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and neutralize
Stop reaction to neutrality；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）It is clear to collect upper strata
Liquid, fermented tea fermentation membrane modifying thing is obtained in vacuum drying.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 1.5 parts by weight are added；（2）In 60 DEG C of conditions
Lower carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 15 parts by weight is first added dropwise, add 2 parts by weight to first
Benzene sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5；（5）Turn after liquid cooling
Move in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 3 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 4 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 3
A kind of collagen peptide lubricating fluid, is made up of following raw material：It is 10 parts of red tea fungus fermented date liquid, 0.8 part of sodium hyaluronate, red
1 part of tea bacterium fermentation membrane modifying thing, 12 parts of collagen peptide, 0.35 part of Cananga odorata quintessence oil, 3.5 parts of water-soluble camellia seed oil, ethoxy
70.8 parts of 0.8 part of urea, 0.75 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 1 parts by weight fermented tea
Fermentation membrane modifying thing and 12 parts by weight collagen peptides are dissolved with 70.8 parts by weight of deionized water；（2）Add the glass of 0.8 parts by weight
Uric acid, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.75 parts by weight hexylene glycol and
0.8 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 3.5 parts by weight water
Dissolubility camellia seed oil and 10 parts by weight red tea fungus fermented date liquids, it is well mixed；（5）0.35 parts by weight Cananga odorata quintessence oil is added, mixing is equal
It is even, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 5 parts by weight, the hardship of 10 parts by weight
110min is boiled in the deionized water mixing of radix scrophulariae, the lily of 5 parts by weight, the white granulated sugar of 48 parts by weight and 1000 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1000 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 50 parts by weight, sealed with gauze
Mouthful, after fermenting 8 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the quality of 100 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
Before be rapidly added the fermented tea fermentation films of 1-3 parts by weight, quick stirring 5min, then is placed under the conditions of -7 DEG C at room temperature
20min, obtain the fermented tea fermentation coating solution that mass concentration is 3%；（3）Sent out in the fermented tea that 100 parts by weight mass concentrations are 3%
The chlorethanol of 30 parts by weight is added in ferment coating solution, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and neutralize
Stop reaction to neutrality；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）It is clear to collect upper strata
Liquid, fermented tea fermentation membrane modifying thing is obtained in vacuum drying.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 1.5 parts by weight are added；（2）In 60 DEG C of conditions
Lower carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 18 parts by weight is first added dropwise, add 2 parts by weight to first
Benzene sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）Liquid cooling
After be transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 5 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 6 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 4
A kind of collagen peptide lubricating fluid, is made up of following raw material：It is 12 parts of red tea fungus fermented date liquid, 0.7 part of sodium hyaluronate, red
0.8 part of tea bacterium fermentation membrane modifying thing, 12 parts of collagen peptide, 0.4 part of Cananga odorata quintessence oil, 3.5 parts of water-soluble camellia seed oil, ethoxy
69.2 parts of 0.6 part of urea, 0.8 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 0.8 parts by weight black tea
Bacterium fermentation membrane modifying thing and 12 parts by weight collagen peptides are dissolved with 69.2 parts by weight of deionized water；（2）Add 0.7 parts by weight
Sodium hyaluronate, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature is kept for 60 DEG C, adds 0.8 parts by weight hexylene glycol
With 0.6 parts by weight ethoxy urea, stirring makes it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 3.5 parts by weight
Water-soluble camellia seed oil and 12 parts by weight red tea fungus fermented date liquids, it is well mixed；（5）0.4 parts by weight Cananga odorata quintessence oil is added, mixing is equal
It is even, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 6 parts by weight, the hardship of 11 parts by weight
110min is boiled in the deionized water mixing of radix scrophulariae, the lily of 4 parts by weight, the white granulated sugar of 50 parts by weight and 1100 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1100 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 55 parts by weight, sealed with gauze
Mouthful, after fermenting 8 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the quality of 100 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
Before be rapidly added the fermented tea fermentation films of 2 parts by weight, quick stirring 5min, then places 20min under the conditions of -7 DEG C at room temperature,
Obtain the fermented tea fermentation coating solution that mass concentration is 2%；（3）It is molten in the fermented tea fermentation film that 100 parts by weight mass concentrations are 2%
The chlorethanol of 30 parts by weight is added in liquid, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and be neutralized to neutrality
Stop reaction；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Supernatant liquor is collected, in
Vacuum drying obtains fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 19 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 6 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 6 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 5
A kind of collagen peptide lubricating fluid, is made up of following raw material：It is 13 parts of red tea fungus fermented date liquid, 0.7 part of sodium hyaluronate, red
1 part of tea bacterium fermentation membrane modifying thing, 10 parts of collagen peptide, 0.35 part of Cananga odorata quintessence oil, 3.5 parts of water-soluble camellia seed oil, ethoxy
69.9 parts of 0.75 part of urea, 0.8 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 1 parts by weight fermented tea
Fermentation membrane modifying thing and 10 parts by weight collagen peptides are dissolved with 69.9 parts by weight of deionized water；（2）Add the glass of 0.7 parts by weight
Uric acid, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.8 parts by weight hexylene glycol and
0.75 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 3.5 parts by weight water
Dissolubility camellia seed oil and 13 parts by weight red tea fungus fermented date liquids, it is well mixed；（5）0.35 parts by weight Cananga odorata quintessence oil is added, mixing is equal
It is even, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 8 parts by weight, the hardship of 12 parts by weight
120min is boiled in the deionized water mixing of radix scrophulariae, the lily of 6 parts by weight, the white granulated sugar of 55 parts by weight and 1200 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1200 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 60 parts by weight, sealed with gauze
Mouthful, after fermenting 9 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the quality of 110 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
Before be rapidly added the fermented tea fermentation films of 3 parts by weight, quick stirring 5min, then places 20min under the conditions of -7 DEG C at room temperature,
Obtain the fermented tea fermentation coating solution that mass concentration is 3%；（3）It is molten in the fermented tea fermentation film that 100 parts by weight mass concentrations are 3%
The chlorethanol of 35 parts by weight is added in liquid, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and be neutralized to neutrality
Stop reaction；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Supernatant liquor is collected, in
Vacuum drying obtains fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 20 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 8 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 7 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 6
A kind of collagen peptide lubricating fluid, is made up of following raw material：It is 7 parts of red tea fungus fermented date liquid, 0.6 part of sodium hyaluronate, red
1.5 parts of tea bacterium fermentation membrane modifying thing, 9 parts of collagen peptide, 0.35 part of Cananga odorata quintessence oil, 3.2 parts of water-soluble camellia seed oil, ethoxy
76.8 parts of 0.75 part of urea, 0.8 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 1.5 parts by weight black tea
Bacterium fermentation membrane modifying thing and 9 parts by weight collagen peptides are dissolved with 76.8 parts by weight of deionized water；（2）Add 0.6 parts by weight
Sodium hyaluronate, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature is kept for 60 DEG C, adds 0.8 parts by weight hexylene glycol
With 0.75 parts by weight ethoxy urea, stirring makes it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 3.2 parts by weight
Water-soluble camellia seed oil and 7 parts by weight red tea fungus fermented date liquids, it is well mixed；（5）0.35 parts by weight Cananga odorata quintessence oil is added, mixing is equal
It is even, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 8 parts by weight, the hardship of 12 parts by weight
120min is boiled in the deionized water mixing of radix scrophulariae, the lily of 6 parts by weight, the white granulated sugar of 55 parts by weight and 1200 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1200 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 60 parts by weight, sealed with gauze
Mouthful, after fermenting 9 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the quality of 110 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
Before be rapidly added the fermented tea fermentation films of 3 parts by weight, quick stirring 5min, then places 20min under the conditions of -7 DEG C at room temperature,
Obtain the fermented tea fermentation coating solution that mass concentration is 3%；（3）It is molten in the fermented tea fermentation film that 100 parts by weight mass concentrations are 3%
The chlorethanol of 35 parts by weight is added in liquid, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and be neutralized to neutrality
Stop reaction；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Supernatant liquor is collected, in
Vacuum drying obtains fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 20 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 8 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 7 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 7
A kind of collagen peptide lubricating fluid, is made up of following raw material：18 parts of red tea fungus fermented date liquid, 1 part of sodium hyaluronate, black tea
0.25 part of bacterium fermentation membrane modifying thing, 13 parts of collagen peptide, 0.45 part of Cananga odorata quintessence oil, 4.5 parts of water-soluble camellia seed oil, ethoxy
61.25 parts of 0.75 part of urea, 0.8 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）It is under normal temperature, 0.25 parts by weight are red
Tea bacterium fermentation membrane modifying thing and 13 parts by weight collagen peptides are dissolved with 61.25 parts by weight of deionized water；（2）Add 1 parts by weight
Sodium hyaluronate, be warming up to 60 DEG C, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.8 parts by weight oneself two
Alcohol and 0.75 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 4.5 weight
The water-soluble camellia seed oil of part and 18 parts by weight red tea fungus fermented date liquids, are well mixed；（5）0.45 parts by weight Cananga odorata quintessence oil is added, is mixed
Close uniformly, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 6 parts by weight, the hardship of 11 parts by weight
110min is boiled in the deionized water mixing of radix scrophulariae, the lily of 4 parts by weight, the white granulated sugar of 50 parts by weight and 1100 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1100 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 55 parts by weight, sealed with gauze
Mouthful, after fermenting 8 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）By the quality of 100 parts by weight
The mixed aqueous solution for the ethoxy urea that the NaOH and mass concentration that concentration is 5% are 6% is cooled to -7 DEG C in advance；（2）Solution is taken advantage of not freeze
Before be rapidly added the fermented tea fermentation films of 2 parts by weight, quick stirring 5min, then places 20min under the conditions of -7 DEG C at room temperature,
Obtain the fermented tea fermentation coating solution that mass concentration is 2%；（3）It is molten in the fermented tea fermentation film that 100 parts by weight mass concentrations are 2%
The chlorethanol of 30 parts by weight is added in liquid, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and be neutralized to neutrality
Stop reaction；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Supernatant liquor is collected, in
Vacuum drying obtains fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 19 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 6 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 6 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 8
A kind of collagen peptide lubricating fluid, is made up of following raw material：18 parts of red tea fungus fermented date liquid, 0.75 part of sodium hyaluronate,
0.7 part of fermented tea fermentation membrane modifying thing, 10 parts of collagen peptide, 0.45 part of Cananga odorata quintessence oil, 4.5 parts of water-soluble camellia seed oil, hydroxyl
66.5 parts of 0.8 part of ethyl urea, 0.9 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 0.7 parts by weight black tea
Bacterium fermentation membrane modifying thing and 10 parts by weight collagen peptides are dissolved with 66.5 parts by weight of deionized water；（2）Add 0.75 parts by weight
Sodium hyaluronate, be warming up to 60 DEG C, stirring makes it dissolve and be well mixed；（3）Temperature keep 60 DEG C, add 0.9 parts by weight oneself two
Alcohol and 0.8 parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 4.5 weight
The water-soluble camellia seed oil of part and 18 parts by weight red tea fungus fermented date liquids, are well mixed；（5）0.45 parts by weight Cananga odorata quintessence oil is added, is mixed
Close uniformly, produce lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 3 parts by weight, the hardship of 10 parts by weight
110min is boiled in the deionized water mixing of radix scrophulariae, the lily of 4 parts by weight, the white granulated sugar of 50 parts by weight and 1000 parts by weight,
Cooled and filtered is stood, deionized water is added in filtrate, filtrate is kept 1000 parts by weight, mixes and adds in container, be put into
The overweight sterilizing 20min of high-temperature sterilization, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 50 parts by weight, sealed with gauze
Mouthful, after fermenting 8 days at normal temperatures and pressures, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）The quality of 95 parts by weight is dense
The mixed aqueous solution spent for 5% NaOH and mass concentration the ethoxy urea for being 6% is cooled to -7 DEG C in advance；（2）Take advantage of before solution do not freeze
The fermented tea fermentation film of 1.5 parts by weight is rapidly added, quickly stirs 5min at room temperature, then 20min is placed under the conditions of -7 DEG C,
Obtain the fermented tea fermentation coating solution that mass concentration is 1.5-3%；（3）Sent out in the fermented tea that 100 parts by weight mass concentrations are 1.5%
The chlorethanol of 20 parts by weight is added in ferment coating solution, 50 DEG C of reaction 2h is warming up to after reacting 2h at room temperature, adds acetic acid and neutralize
Stop reaction to neutrality；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）It is clear to collect upper strata
Liquid, fermented tea fermentation membrane modifying thing is obtained in vacuum drying.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 1.5 parts by weight are added；（2）In 60 DEG C of conditions
Lower carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 15 parts by weight is first added dropwise, add 2 parts by weight to first
Benzene sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5；（5）Turn after liquid cooling
Move in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 3 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 4 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiment 9
A kind of collagen peptide lubricating fluid, is made up of following raw material：It is 16 parts of red tea fungus fermented date liquid, 0.8 part of sodium hyaluronate, red
1 part of tea bacterium fermentation membrane modifying thing, 11 parts of collagen peptide, 0.4 part of Cananga odorata quintessence oil, 4 parts of water-soluble camellia seed oil, ethoxy urea
65 parts of 0.9 part, 0.9 part of hexylene glycol and deionized water.
A kind of preparation method of collagen peptide lubricating fluid, comprises the following steps：（1）Under normal temperature, by 1 parts by weight fermented tea
Fermentation membrane modifying thing and 11 parts by weight collagen peptides are dissolved with 65 parts by weight of deionized water；（2）Add the glass urine of 0.8 parts by weight
Acid, 60 DEG C are warming up to, stirring makes it dissolve and be well mixed；（3）Temperature is kept for 60 DEG C, adds 0.9 parts by weight hexylene glycol and 0.9
Parts by weight ethoxy urea, stirring make it dissolve and be well mixed；（4）Room temperature is cooled to, sequentially adds 4 parts by weight water-soluble oil
Tea-seed oil and 16 parts by weight red tea fungus fermented date liquids, it is well mixed；（5）0.4 parts by weight Cananga odorata quintessence oil is added, is well mixed, produces
Lubricating fluid.
Further, the red tea fungus fermented date liquid is made by following steps：By the black tea of 2 parts by weight, 8 parts by weight it is bitter profound
100min is boiled in the deionized water mixing of ginseng, the lily of 2 parts by weight, the white granulated sugar of 45 parts by weight and 900 parts by weight, stands
Cooled and filtered, deionized water is added in filtrate, filtrate is kept 900 parts by weight, mixed and add in container, be put into high temperature and go out
The overweight sterilizing 20min of bacterium, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 45 parts by weight, sealed with gauze, normal
After being fermented 7 days under normal temperature and pressure, red tea fungus fermented date liquid is obtained with screen filtration.
Further, the fermented tea fermentation membrane modifying thing is prepared by following steps：（1）The quality of 95 parts by weight is dense
The mixed aqueous solution spent for 5% NaOH and mass concentration the ethoxy urea for being 6% is cooled to -7 DEG C in advance；（2）Take advantage of before solution do not freeze
The fermented tea fermentation film of 2 parts by weight is rapidly added, quickly stirs 5min at room temperature, then 20min is placed under the conditions of -7 DEG C, is obtained
To the fermented tea fermentation coating solution that mass concentration is 2%；（3）In the fermented tea fermentation coating solution that 100 parts by weight mass concentrations are 2%
The middle chlorethanol for adding 25 parts by weight, 50 DEG C of reaction 2h are warming up to after reacting 2h at room temperature, addition acetic acid is neutralized to neutrality and stopped
Only react；（4）After reacted solution dialysis, 10min separation is centrifuged under 400 r/min；（5）Collect supernatant liquor, Yu Zhen
Sky is dried to obtain fermented tea fermentation membrane modifying thing.
Further, the water-soluble camellia seed oil is prepared by following steps：（1）In three equipped with spherical reflux condensing tube
In neck flask, 100 parts by weight Natrulon H-10s and the saturation disodium phosphate soln of 2 parts by weight are added；（2）Under the conditions of 60 DEG C
Carry out stirring in water bath, reaction time 1h；（3）Then the camellia seed oil of 14 parts by weight is first added dropwise, add 2 parts by weight to toluene
Sulfonic acid continues 60 DEG C of reaction 1h；（4）Saturated sodium bicarbonate solution is added dropwise to the pH value of solution to 6.5-7.5；（5）After liquid cooling
It is transferred in separatory funnel, it is water-soluble camellia seed oil to be directly isolated to obtain lower floor's solution.
Further, described collagen peptide through the following steps that prepare：（1）Fish-skin is cleaned, air-dries surface
Moisture；（2）Weigh 100 parts by weight to add in reaction bulb, the NaOH and quality that the mass concentration for adding 300 parts by weight is 0.4% are dense
Spend for 0.6% H2SO4Mixed aqueous solution processing, then it is washed to neutrality；（3）Add 100 parts by weight distilled water, 60 DEG C of constant temperature stirrings
2h is extracted, filter cleaner after room temperature is cooled to, it is standby to obtain collagen extract solution；（4）Extracted in collagen
The concentration that 6 parts by weight are added in liquid is 40U/mL trypsase, adjusts pH=8,6h is digested at 40 DEG C；（5）Add 4 parts by weight
Mass concentration is 2% acid protease, adjusts pH=4.5, and 8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both
Collagen peptide extract solution, then obtain powder after being freeze-dried.
Embodiments of the invention are the foregoing is only, are not intended to limit the scope of the invention, it is every to utilize this hair
The equivalent structure or equivalent flow conversion that bright description is made, or directly or indirectly it is used in other related technology necks
Domain, it is included within the scope of the present invention.
Claims (10)
1. a kind of collagen peptide lubricating fluid, it is characterised in that be made up of following raw material：Red tea fungus fermented date liquid 5-20
Part, sodium hyaluronate 0.5-1.2 parts, fermented tea fermentation membrane modifying thing 0.2-2 parts, collagen peptide 8-15 parts, Cananga odorata quintessence oil 0.3-0.5
Part, water-soluble camellia seed oil 3-5 parts, ethoxy urea 0.5-1 parts, hexylene glycol 0.5-1 parts and deionized water 60-80 parts.
2. a kind of collagen peptide lubricating fluid as claimed in claim 1, it is characterised in that the red tea fungus fermented date liquid is by following
Raw material is made：Black tea 4-9 parts, picria fel tarrae 8-12 parts, wormwood 2-6 parts, white granulated sugar 45-55 parts, deionized water 900-
1200 parts and black tea mother bacterial liquid 45-60 parts.
A kind of 3. collagen peptide lubricating fluid as claimed in claim 1, it is characterised in that the fermented tea fermentation membrane modifying thing
It is made up of following raw material：Mass concentration be 1.5-3% fermented tea ferment 100 parts of coating solution, chlorethanol 20-35 parts and
Acetic acid 2-10 parts；The fermented tea fermentation coating solution is made up of following raw material：NaOH and the quality that mass concentration is 5%
Concentration is mixed aqueous solution 90-110 parts of 6% ethoxy urea and fermented tea fermentation film 1-3 parts.
A kind of 4. collagen peptide lubricating fluid as claimed in claim 1, it is characterised in that the water-soluble camellia seed oil by with
Lower raw material is made：
100 parts of Natrulon H-10；
Saturation disodium phosphate soln 1-2 parts；
Camellia seed oil 12-20 parts；
2 parts of p-methyl benzenesulfonic acid；
Saturated sodium bicarbonate solution 1-3 parts.
5. a kind of collagen peptide lubricating fluid as claimed in claim 1, it is characterised in that the collagen peptide is by following heavy
Amount part raw material is made：Dry 100 parts of fish-skin, the NaOH that mass concentration is 0.4% and the H that mass concentration is 0.6%2SO4Mix water-soluble
The acid protease 3-7 that trypsase 1-8 part and mass concentration that 300 parts of liquid, 100 parts of distilled water, concentration are 40U/mL are 2%
Part.
6. a kind of preparation method of collagen peptide lubricating fluid, it is characterised in that comprise the following steps：（1）Under normal temperature, by 0.2-
2 parts by weight fermented teas fermentation membrane modifying thing and 8-15 parts by weight collagen peptide 60-80 parts by weight of deionized water dissolve；（2）
The sodium hyaluronate of 0.5-1.2 parts by weight is added, is warming up to 60 DEG C, stirring makes it dissolve and be well mixed；（3）Temperature is kept for 60 DEG C,
0.5-1 parts by weight hexylene glycol and 0.5-1 parts by weight ethoxy urea are added, stirring makes it dissolve and be well mixed；（4）It is cooled to
Room temperature, 3-5 parts by weight water-soluble camellia seed oil and 5-20 parts by weight red tea fungus fermented date liquids are sequentially added, be well mixed；（5）Add
0.3-0.5 parts by weight Cananga odorata quintessence oils, it is well mixed, produces lubricating fluid.
7. a kind of collagen peptide lubricating fluid as claimed in claim 6, it is characterised in that the red tea fungus fermented date liquid is by following
Step is made：By the black tea of 4-9 parts by weight, the picria fel tarrae of 8-12 parts by weight, the lily of 2-6 parts by weight, 45-55 parts by weight
100-120min is boiled in the mixing of the deionized water of white granulated sugar and 900-1200 parts by weight, cooled and filtered is stood, in filtrate
Deionized water is added, filtrate is kept 900-1200 parts by weight, mixes and adds in container, be put into the overweight sterilizing of high-temperature sterilization
20min, sterilizing are cooled to room temperature after terminating, add the black tea mother bacterial liquid of 45-60 parts by weight, sealed with gauze, in normal temperature and pressure
After lower fermentation 7 days, red tea fungus fermented date liquid is obtained with screen filtration.
A kind of 8. collagen peptide lubricating fluid as claimed in claim 6, it is characterised in that the fermented tea fermentation membrane modifying thing
It is to be prepared by following steps：（1）The ethoxy that the NaOH and mass concentration that mass concentration by 90-110 parts by weight is 5% are 6%
The mixed aqueous solution of urea is cooled to -7 DEG C in advance；（2）The fermented tea fermentation film that 1-3 parts by weight are rapidly added before solution does not freeze is taken advantage of, in
5min is quickly stirred at room temperature, then 20min is placed under the conditions of -7 DEG C, obtains the fermented tea fermentation film that mass concentration is 1.5-3%
Solution；（3）The chloroethene of 20-35 parts by weight is added in the fermented tea that 100 parts by weight mass concentrations are 1.5-3% ferments coating solution
Alcohol, 50 DEG C of reaction 2h are warming up to after reacting 2h at room temperature, add acetic acid and be neutralized to neutral stopping reaction；（4）It is reacted molten
After liquid dialysis, 10min separation is centrifuged under 400 r/min；（5）Supernatant liquor is collected, fermented tea fermentation is obtained in vacuum drying
Membrane modifying thing.
A kind of 9. collagen peptide lubricating fluid as claimed in claim 6, it is characterised in that the water-soluble camellia seed oil by with
It is prepared by lower step：（1）In the three-neck flask equipped with spherical reflux condensing tube, 100 parts by weight Natrulon H-10s and 1-2 weights are added
Measure the saturation disodium phosphate soln of part；（2）Stirring in water bath, reaction time 1h are carried out under the conditions of 60 DEG C；（3）Then first it is added dropwise
The camellia seed oil of 12-20 parts by weight, the p-methyl benzenesulfonic acid for adding 2 parts by weight continue 60 DEG C of reaction 1h；（4）Unsaturated carbonate is added dropwise
Hydrogen sodium solution is to the pH value of solution to 6.5-7.5；（5）It is transferred to after liquid cooling in separatory funnel, is directly isolated to obtain lower floor
Solution is water-soluble camellia seed oil.
10. a kind of collagen peptide lubricating fluid as claimed in claim 6, it is characterised in that the collagen peptide is to pass through
Prepared by following steps：（1）Fish-skin is cleaned, air-dries surface moisture；（2）Weigh 100 parts by weight to add in reaction bulb, add
The NaOH and mass concentration that the mass concentration of 300 parts by weight is 0.4% are 0.6% H2SO4Mixed aqueous solution processing, then be washed to
Property；（3）100 parts by weight distilled water are added, 60 DEG C of constant temperature stirring extraction 2h, filter cleaner after room temperature is cooled to, obtains fish glue from skin
Former protein extract is standby；（4）The concentration that 1-8 parts by weight are added in collagen extract solution is 40U/mL tryptoses
Enzyme, pH=8 are adjusted, 6h is digested at 40 DEG C；（5）It is 2% acid protease to add 3-7 parts by weight mass concentration, adjusts pH=4.5,
8h is digested at being 50 DEG C in temperature；（6）Filtered again by enzyme deactivation, both collagen peptide extract solution, then after being freeze-dried
Obtain powder.
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| CN (1) | CN107789611B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200343A (en) * | 2018-08-29 | 2019-01-15 | 杨帆 | A kind of sterilization spermicidal lubricant suitable for vagina |
| CN115054740A (en) * | 2022-08-18 | 2022-09-16 | 北京世纪伟信医药科技有限公司 | Hypoallergenic collagen peptide human body cavity lubricant and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405610A (en) * | 2013-05-30 | 2013-11-27 | 德域企业有限公司 | Compact-type water-soluble human lubricant, preparation method of lubricant and condom |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405610A (en) * | 2013-05-30 | 2013-11-27 | 德域企业有限公司 | Compact-type water-soluble human lubricant, preparation method of lubricant and condom |
Non-Patent Citations (3)
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| 李昊燃: "红茶菌中细菌纤维素产生菌的筛选鉴定及发酵条件优化", 《中国优秀硕士学位论文全文数据库基础科学辑》 * |
| 王国增等: "红茶菌的抑菌作用及抗氧化性", 《中国食品学报》 * |
| 郭洪辉等: "河豚鱼皮胶原寡肽制备工艺的优化", 《食品工业科技》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200343A (en) * | 2018-08-29 | 2019-01-15 | 杨帆 | A kind of sterilization spermicidal lubricant suitable for vagina |
| CN115054740A (en) * | 2022-08-18 | 2022-09-16 | 北京世纪伟信医药科技有限公司 | Hypoallergenic collagen peptide human body cavity lubricant and preparation method thereof |
| CN115054740B (en) * | 2022-08-18 | 2022-11-18 | 山东多美康生物医药有限公司 | Hypoallergenic collagen peptide human body cavity lubricant and preparation method thereof |
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| Publication number | Publication date |
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| CN107789611B (en) | 2021-05-28 |
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