CN102847028A - Traditional Chinese medicine disinfectant and preparation method thereof - Google Patents
Traditional Chinese medicine disinfectant and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a preparation method of a traditional Chinese medicine disinfectant. The disinfectant comprises the following ingredients: 10-40 parts of common cnidium fruit, 10-40 parts of Oldenlandia diffusa, 5-20 parts of wild pepper, 5-20 parts of mint, 5-20 parts of sophora flavescens, and 5-20 parts of stemona. The preparation method comprises the following steps: extracting the above ingredients by heating reflux extraction method, filtering, concentrating, cooling, standing for 12h, and taking a supernatant; dissolving and uniformly mixing additives comprising 3-5 parts of borneol, 1-2 parts of menthol, 10-20 parts of propylene glycol, and 10-20 parts of polyoxyethylene hydrogenated castor oil, then adding the mixture in the supernatant, stirring and mixing uniformly. The disinfectant disclosed herein is mild and safe, and experiments prove that the disinfectant has significant sterilization effect.
Description
Technical field
The invention belongs to Chinese herbal medicine daily use chemicals product technical field, particularly a kind of Chinese medicine antiseptic and preparation method thereof.
Background technology
The use of disinfectant also makes people that disinfectant has been had more understanding in the popular important function that played of SARS epidemic period for prevention and control SARS.Along with the development of society, disinfectant has obtained using more and more widely in people's daily life, and the disinfectant that exists on the market at present is various in style, mainly is divided into following a few class:
(1) chlorine-containing disinfectant, such as bleaching powder, calcium hypochlorite, 84 disinfectant solution etc., this type of disinfectant is chlorine-containing compound, has certain corrosivity, after long-term and a large amount of the suction, can stimulate human body skin and respiratory mucosa, cause the symptoms such as eye is dry and astringent, xerostomia, dry cough, chafing.
(2) peroxide disinfectant, such as peracetic acid, hydrogen peroxide, ozone etc., the suction of this type of disinfectant can cause cough, asthma, dyspnea etc., and severe patient causes the symptoms such as chemical bronchitis.
(3) surfactant type disinfectant, such as povidone iodine, bromo geramine, hibitane etc., if this type of disinfectant concentration is higher, contact skin and eyes can cause the consequence such as burn.
Existing disinfectant mostly is chemicals, brings certain harm to human health.In the Chinese herbal disinfectant that the present stage people develop, natural safe pure Chinese medicinal preparation, the bacteriostasis and sterilization DeGrain, therefore many and chemicals compatibility uses the effect that reaches antibacterial sterilization, to a certain extent health is exerted an influence.
Summary of the invention
The objective of the invention is provides a kind of Chinese medicine antiseptic with better bacteriostasis and sterilization effect for above-mentioned defective of the prior art.
Another object of the present invention provides the preparation method of Chinese herbal disinfectant.
The technical scheme taked of the present invention is for achieving the above object:
A kind of for the Chinese medicine antiseptic compositions, formed by following raw material: Fructus Cnidii, Herba Hedyotidis Diffusae, Pericarpium Zanthoxyli, Herba Menthae, Radix Sophorae Flavescentis, the Radix Stemonae, Borneolum Syntheticum, Mentholum, polyoxyethylene hydrogenated Oleum Ricini and propylene glycol.
The invention provides another preferred technical scheme is: a kind of for the Chinese medicine antiseptic compositions, raw material by following weight portion forms: Fructus Cnidii 10-40 part, Herba Hedyotidis Diffusae 10-40 part, Pericarpium Zanthoxyli 5-20 part, Herba Menthae 5-20 part, Radix Sophorae Flavescentis 5-20 part, Radix Stemonae 5-20 part, Borneolum Syntheticum 3-5 part, Mentholum 1-3 part, polyoxyethylene hydrogenated Oleum Ricini 10-20 part, propylene glycol 10-20 part.
The invention provides another preferred technical scheme is: a kind of for the Chinese medicine antiseptic compositions, raw material by following weight portion forms: Fructus Cnidii 10-30 part, Herba Hedyotidis Diffusae 10-30 part, Pericarpium Zanthoxyli 5-15 part, Herba Menthae 5-15 part, Radix Sophorae Flavescentis 5-15 part, Radix Stemonae 5-15 part, Borneolum Syntheticum 3-4 part, Mentholum 1-2 part, polyoxyethylene hydrogenated Oleum Ricini 10-16 part, propylene glycol 10-16 part.
The invention provides another preferred technical scheme is: a kind of for the Chinese medicine antiseptic compositions, raw material by following weight portion forms: 20 parts of Fructus Cnidiis, 20 parts of Herba Hedyotidis Diffusaes, 10 parts in Pericarpium Zanthoxyli, 10 parts of Herba Menthaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of the Radixs Stemonae, 3.2 parts of Borneolum Syntheticums, 1.6 parts of Mentholums, 16 parts of polyoxyethylene hydrogenated Oleum Ricini, 16 parts of propylene glycol.
The present invention also provides a kind of preparation method of Chinese medicine antiseptic, get the Chinese crude drug Fructus Cnidii, Herba Hedyotidis Diffusae, Pericarpium Zanthoxyli, Herba Menthae, Radix Sophorae Flavescentis and the Radix Stemonae are put into container, give and add Chinese medicine gross weight 10-15 water doubly in the container, heating and refluxing extraction 1.5-2h, filter, medicinal residues add Chinese medicine gross weight 7-10 water doubly again, heating and refluxing extraction 1.5-2h, merge gained filtrate twice, filtrate after the merging is concentrated into 0.2-0.3g/ml, get supernatant after leaving standstill 10-15h, get Borneolum Syntheticum and Mentholum and be dissolved in propylene glycol and the polyoxyethylene hydrogenated Oleum Ricini, behind the mix homogeneously, obtain modulating solution, modulation solution is added in the supernatant of Chinese medicine extraction liquid, after stirring, namely gets Chinese medicine antiseptic.
The present invention also provides the Chinese medicine antiseptic according to described method preparation.
The beneficial effect of the embodiment of the invention is: this Chinese medicine antiseptic has the effects such as pathogenic microbe killing, fungus, parasite dispelling wind and heat pathogens, antiinflammatory are antibacterial, killing parasites for relieving itching, acts on the effect that human body skin has killing parasites for relieving itching, anti-inflammatory analgetic; Act on body surface and have cleaning actions such as killing invisible pathogenic microorganism, fungus, parasite; This Chinese medicine antiseptic is take natural Chinese medicinal herb as main sterilizing effect composition, safety easy to use, and natural environmental-protective, zest is little, and the scope of application is very extensive, can be applicable to people, animal and body surface.Sterilization experiment studies have shown that this Chinese medicine antiseptic has stronger killing action to escherichia coli, Candida albicans etc., and staphylococcus aureus is had certain killing action.
The medicinal function of each Chinese medicine of the present invention is:
Fructus Cnidii: warm in nature, acrid in the mouth, hardship.Function cures mainly: warming the kidney to invigorate YANG, dampness is dispeled the wind, parasite killing.External can be controlled vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis; Modern pharmacological research proves: Compound Fructus Cnidium has the anti-trichomonal effect, and trichomonal vaginitis is had good therapeutic effect, and the osthole that contains in the Fructus Cnidii, bergapton in vitro tests have stronger activity to Trichophyton.
Herba Hedyotidis Diffusae: cold in nature, bitter in the mouth, light, main effect heat-clearing and toxic substances removing, the various inflammation of kind treatment clinically are usually used in treating venom and all kinds of inflammation, use with the other medicines compatibility to have the effect that strengthens effect.
Pericarpium Zanthoxyli: warm in nature, acrid in the mouth, fiber crops.Function cures mainly: the effect of removing damp and stopping pain, parasite killing detoxifcation, antipruritic solution raw meat, Pericarpium Zanthoxyli is to 10 kinds of gram positive bacterias such as anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and Staphylococcus albus, bacillus subtilis, and the enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have obvious inhibitory action.
Herba Menthae: acrid in the mouth cool in nature has the effects such as the wind heat of dispersing, rash detoxifcation, antipruritic pain relieving.The volatile oil local topical that contains in the Herba Menthae has refrigerant, antiinflammatory, pain relieving, the effect such as antipruritic to skin, and the Herba Menthae decoct has preferably inhibitory action to herpes simplex virus, staphylococcus aureus, anthrax bacillus, escherichia coli, bacillus pyocyaneus etc.
Radix Sophorae Flavescentis: bitter in the mouth cold in nature, function cures mainly: heat clearing and damp drying, parasite killing, diuresis.Be used for hematodiarrhoea, have blood in stool jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.Radix Sophorae Flavescentis extract all has inhibitory action to staphylococcus aureus, trichophyton, Trichophyton concentricunm, trichophyton, Du's big belly budlet spore tinea bacterium difficult to understand etc., and the mice inflammation that the auricle edema that the matrine that contains in the Radix Sophorae Flavescentis causes mouse knoting oil, acetic acid cause all has inhibitory action.
The Radix Stemonae: slightly warm in nature, sweet-bitter flavor are used for head louse, body louse, enterobiasis, pudendum Pruritus etc. outward.In vitro tests proves that Radix Stemonae extracting solution has certain effect to equal tools of pathogenic microorganism such as staphylococcus aureus, escherichia coli, bacillus pyocyaneus, trichophytons.The parasites such as ascarid, pinworm are had stronger killing action, and the insecticides such as body louse, pubic louse also have preferably killing action.
Further specify effect of the present invention below in conjunction with test:
1. experiment purpose
Check Chinese medicine antiseptic of the present invention to staphylococcus aureus, escherichia coli or, the bactericidal effect of yeast, Candida albicans.
2. instrument and reagent
2.1 instrument
RE-52A type Rotary Evaporators is produced by the inferior flourish instrument and equipment company limited in Shanghai; HH-2K4 type two row four hole intelligence water baths are produced by Yuhua Instrument Co., Ltd., Gongyi City; The single two-sided clean work station of SW-CJ-1F type is produced by Purifying Equipment Co., Ltd., Suzhou; 8HP-080 type bacteria bio incubator is produced by the grand experimental facilities company limited of upper Nereid; YXQ-LS-50S11 type high-pressure sterilizing pot is produced by Medical Equipment Plant of Shanghai Boxun Industrial Co., Ltd.; FA1004 type analysis balance is produced by Heaven, Shanghai precision instrument company limited; The DC-TO test-type extracts thickener, is produced by upper Haidah journey experimental facilities company limited.
2.2 reagent
Chinese medicine antiseptic prescription: Fructus Cnidii 20g, Herba Hedyotidis Diffusae 20g, Pericarpium Zanthoxyli 10g, Herba Menthae 10g, Radix Sophorae Flavescentis 10g, Radix Stemonae 10g, Borneolum Syntheticum 3.2g, Mentholum 1.6g, propylene glycol 16g, polyoxyethylene hydrogenated Oleum Ricini RH
4016g.
1.3 experimental strain
Antibacterial: staphylococcus aureus (ATCC 6538), escherichia coli (8099 or ATCC 25922); Yeast: Candida albicans (ATCC 10231) provides by the Guangdong Microbes Inst.
3. experimental technique
3.1 Chinese medicine antiseptic preparation technology
Get above-mentioned Chinese crude drug, add 12 times of water gagings, heating and refluxing extraction 2h filters, and medicinal residues add 8 times of water gaging heating and refluxing extraction 2h again, merging filtrate, and filtrate is concentrated into 0.25g/ml, leaves standstill 12h, gets supernatant, gets Borneolum Syntheticum and Mentholum and is dissolved in propylene glycol and RH
40In, mix homogeneously obtains modulating solution, and modulation solution is mixed with the supernatant of Chinese crude drug, after stirring, namely gets Chinese medicine antiseptic.
3.2 bactericidal property method of testing
3.2.1 microbiological contamination print preparation
Get the bacterial strain nutrient agar inclined-plane fresh cultured thing in the 3rd generation～14 generation (18h～24h), wash lawn with 5mL, 0.03mol/L, pH value 7.2-7.4 phosphate buffer (PBS), the above-mentioned PBS of rear usefulness is diluted to desired concn, getting 100 μ l drips in print and (on the 2.0cm * 3.0cm), makes bacterial count recovered reach 1 * 10
4Cfu/ sheet～9 * 10
4The cfu/ sheet.
2.2.2 bacterium solution preparation
(18h～24h), 7.2-7.4PBS washes lawn with the 5ml0.03mol/L pH value, is diluted to desired concn with above-mentioned PBS after making bacterium suspend evenly to get the bacterial strain nutrient agar inclined-plane fresh cultured thing in the 3rd generation～14 generation.
3.2.3 nertralizer identification experiment
The test Chinese medicine antiseptic, test organisms is staphylococcus aureus (ATCC6538), nertralizer is the mixed solution of 0.5%wt glycine, 0.5%wt tween 80 and 0.1%wt lecithin, and the neutralization time is 1min, in Chinese medicine antiseptic and the nertralizer and after obtain neutralized reaction product solution.During test, become the desired concn bacteria suspension with the phosphate buffer dilution test bacterium of 1% peptone.Getting bacteria suspension drips to dye in the white plain of defat and (on the 1.0cm * 1.0cm), makes the bacterium sheet.With Chinese medicine antiseptic, nertralizer, neutralized reaction product solution and 0.03mol/L, pH value 7.2-7.4PBS, in 19～21 ℃ of water-baths, be incubated 5-10min first.Test establish 8 groups be respectively Chinese medicine antiseptic+(bacterium sheet), (Chinese medicine antiseptic+bacterium sheet)+nertralizer, nertralizer+bacterium sheet, (neutralized reaction product solution)+bacterium sheet, PBS+ bacterium sheet (normal bacteria contrast), do not add bacterium PBS contrast, do not add the nertralizer contrast of bacterium, the culture medium of not inoculating bacterium contrasts.Result of the test is when the 6th, 7,8 group not long bacterium; 3rd, bacterium differs and is no more than 10% between 4,5 groups of groups; The 1st group not long bacterium or long bacterium amount are far below the 2nd group; When the 2nd group leader bacterium amount surpasses the 50cfu/ sheet, for selected nertralizer and concentration thereof suitable.Test repeats 3 times.
3.2.4 bactericidal assay
Adopt carrier to soak the test method of quantitative sterilization.Test organisms 24h slant culture is washed with above-mentioned PBS, and (concentration of requirement is: drip on the contrast print with 100 μ l, bacterial count recovered is 1 * 10 to make bacteria suspension
4Cfu/ sheet～9 * 10
4The cfu/ sheet).Get that (each 4 of 2.0cm * 3.0cm) and contrast prints (with the sample homogeneous material, equal size, but do not contain anti-biotic material, and through sterilization treatment) are divided into 4 groups and place in 4 sterilization plates by coupons.Get above-mentioned bacteria suspension, dripped 100 μ l at each by coupons and contrast print respectively, evenly coating, the beginning timing, effect 20min contains the corresponding nertralizer of 5ml in vitro with the print input respectively with aseptic tweezer, fully mixing, do suitably dilution, then get wherein 2～3 dilution factors, draw respectively 0.5ml, place two plates, nutrient agar (antibacterial) or sabouraud's agar (yeast) 15ml with cold to 40 ℃～45 ℃ pour into, rotate plate, make it full and uniform, it is dull and stereotyped that agar solidifies rear upset, cultivate 48h (antibacterial) or 72h (yeast), do the viable bacteria colony counting for 35 ℃ ± 2 ℃.Test repeats 3 times, is calculated as follows sterilizing rate:
In the formula: X is sterilizing rate, %; N
CBe the average clump count of control sample, cfu/ sheet; N
SBe tested sample average clump count, cfu/ sheet.
Evaluation criterion: sterilizing rate 〉=90%, product has bactericidal action.
4. experimental result
4.1 in and qualification test
Result of the test shows, with the mixed solution+0.03mol/L that contains 0.5%wt glycine, 0.5%wt tween 80 and 0.1%wt lecithin, pH value 7.2-7.4PBS solution can in and the residual disinfectancy agent, and nertralizer and neutralized reaction product solution without impact, show that this nertralizer is applicable to this compound Chinese herb disinfectant bactericidal assay on trial growth of microorganism.
Table 1 nertralizer qualification test
4.2 Chinese medicine antiseptic effect different time is to the killing effect of antibacterial
4.2.1 the bactericidal effect to escherichia coli
Experimental result shows that Chinese medicine antiseptic is under normal temperature condition, and test repeats 3 times, and effect 1min is 99.65% to the escherichia coli killing rate, and behind the effect 5min, killing rate reaches more than 99.9%.The results are shown in Table 5.
The bactericidal effect of table 2 pair escherichia coli
4.2.2 the bactericidal effect to staphylococcus aureus
Experimental result shows that Chinese medicine antiseptic is under normal temperature condition, and test repeats 3 times, and effect 1min, 5min, 10min are respectively 53.67%, 72.68% and 88.93% to the escherichia coli killing rate.Behind the effect 20min, killing rate reaches 99.97%.The results are shown in Table 6.
The bactericidal effect of table 3 pair staphylococcus aureus
4.2.3 the bactericidal effect to Candida albicans
Experimental result shows, Chinese medicine antiseptic is under normal temperature condition, and test repeats 3 times, and effect 1min, 5min, 10min are respectively 95.34%, 99.82%, 99.96% and 99.97% to the Candida albicans average kill ratio, behind the effect 20min, killing rate reaches more than 99.9%.The results are shown in Table 6.
The bactericidal effect of table 4 pair Candida albicans
4.3 stability test
4.3.1 Chinese medicine antiseptic is placed front and back to the killing effect of escherichia coli
Experimental result shows that Chinese herbal disinfectant stock solution was positioned over 37 ℃ of incubators after 90 days, on the killing effect of escherichia coli without impact.
Table 5 Chinese medicine antiseptic is placed front and back to the killing effect of escherichia coli
4.3.2 Chinese medicine antiseptic is placed front and back to the killing effect of staphylococcus aureus
Experimental result shows that Chinese herbal disinfectant stock solution was positioned over 37 ℃ of incubators after 90 days, on the killing effect of staphylococcus aureus without impact.
Table 6 Chinese medicine antiseptic is placed front and back to the killing effect of staphylococcus aureus
4.3.3 Chinese medicine antiseptic is placed front and back to the killing effect of Candida albicans
Experimental result shows that Chinese herbal disinfectant stock solution was positioned over 37 ℃ of incubators after 90 days, on the killing effect of Candida albicans without impact.
Table 7 Chinese medicine antiseptic is placed front and back to the killing effect of Candida albicans
5. brief summary
This experiment adopts the heating and refluxing extraction method that Chinese medicine composition (Fructus Cnidii, Herba Hedyotidis Diffusae, Pericarpium Zanthoxyli, Herba Menthae, Radix Sophorae Flavescentis, the Radix Stemonae) is extracted extracting solution and RH
40, make a kind of Chinese medicine antiseptic behind the Borneolum Syntheticum, Mentholum, propylene glycol mixing, adopt the different production scales of lab scale and pilot scale, by the bactericidal action to different strains such as escherichia coli, staphylococcus aureus, Candida albicans, estimate the Chinese medicine antiseptic product effect of lab scale and pilot scale different batches.Experimental result shows, the Chinese medicine antiseptic of different production batch all has bactericidal action, wherein the lab scale experimental result shows, the 0.25g/ml Chinese medicine antiseptic is to escherichia coli, staphylococcus aureus and Candida albicans effect 20min, and killing rate all reaches more than 96%.
6. experiment is discussed
In the compositions of Chinese medicine antiseptic of the present invention, Fructus Cnidii acrid in the mouth warm in nature is bitter, has dampness and dispels the wind, the effect of killing parasites for relieving itching; Pericarpium Zanthoxyli acrid in the mouth warm in nature, have the effect of removing damp and stopping pain, killing parasites for relieving itching, modern pharmacology experimental results show that it has obvious inhibitory action to charcoal maggot bacillus, staphylococcus aureus, escherichia coli etc.; Herba Menthae acrid in the mouth cool in nature, have the effect of dispersing wind heat, anti-itch detoxification, wherein volatile oil component has extremely strong antimicrobial antiphlogistic effect in the Folium Menthae extract; Radix Sophorae Flavescentis bitter in the mouth Great Cold, the effect of tool killing parasites for relieving itching, heat clearing and damp drying, modern study shows that the Radix Sophorae Flavescentis aqueous extract has stronger killing action to multiple funguses such as trichophyton, Trichophyton concentricunm; Radix Stemonae sweet-bitter flavor, slightly warm in nature, disinsection efficiency is strong, and experiment shows that Radix Stemonae extracting solution all has certain killing action to pathogenic microorganism, parasite, insecticide etc.; Herba Hedyotidis Diffusae is cold in nature, bitter in the mouth is light, main effect heat-clearing and toxic substances removing, use with other medicine compatibility, but the enhancing composition drug effect, and this Chinese medicine composition is in strict accordance with traditional Chinese medical science compatibility theory, all medicines share, have pathogenic microbe killing, parasite killing, antiinflammatory, the effect such as antipruritic, entire combination thing compatibility uses, and strengthens the disinfectant effect.
The specific embodiment
The invention will be further described below in conjunction with concrete experiment, but not as a limitation of the invention.
Embodiment 1:
Take by weighing Chinese medicine and raw material (kilogram) according to following weight:
Fructus Cnidii 20, Herba Hedyotidis Diffusae 20, Pericarpium Zanthoxyli 10, Herba Menthae 10, Radix Sophorae Flavescentis 10, the Radix Stemonae 10, Borneolum Syntheticum 3.2, Mentholum 1.6, RH
4016, propylene glycol 16.
The preparation method of Chinese medicine antiseptic:
Get 20 kilograms of Fructus Cnidiis, 20 kilograms of Herba Hedyotidis Diffusaes, 10 kilograms in Pericarpium Zanthoxyli, 10 kilograms of Herba Menthaes, 10 kilograms of Radix Sophorae Flavescentiss and 10 kilograms of Six-element Chinese medicines of the Radix Stemonae and put into container, give the water that adds 12 times of Chinese medicine gross weights in the container, heating and refluxing extraction 2h, filter, medicinal residues add the water of 8 times of Chinese medicine gross weights again, heating and refluxing extraction 2h, merge gained filtrate twice, filtrate after the merging is concentrated into 0.25g/ml, get supernatant after leaving standstill 12h, get 1.6 kilograms of 3.2 kilograms of Borneolum Syntheticums and Mentholums and be dissolved in 16 kilograms of propylene glycol and RH
40In 16 kilograms, behind the mix homogeneously, obtain modulating solution, modulation solution is added in the supernatant of Chinese medicine extraction liquid, after stirring, namely get Chinese medicine antiseptic.
Embodiment 2:
Take by weighing Chinese medicine and raw material (kilogram) according to following weight:
Fructus Cnidii 25, Herba Hedyotidis Diffusae 25, Pericarpium Zanthoxyli 9, Herba Menthae 9, Radix Sophorae Flavescentis 9, the Radix Stemonae 9, Borneolum Syntheticum 3.44, Mentholum 1.72, RH
4017.2, propylene glycol 17.2.
The preparation method of Chinese medicine antiseptic:
Get 25 kilograms of Fructus Cnidiis, 25 kilograms of Herba Hedyotidis Diffusaes, 9 kilograms in Pericarpium Zanthoxyli, 9 kilograms of Herba Menthaes, 9 kilograms of Radix Sophorae Flavescentiss and 9 kilograms of Six-element Chinese medicines of the Radix Stemonae and put into container, give the water that adds 10 times of Chinese medicine gross weights in the container, heating and refluxing extraction 1.5h, filter, medicinal residues add the water of 7 times of Chinese medicine gross weights again, heating and refluxing extraction 2h, merge gained filtrate twice, filtrate after the merging is concentrated into 0.3g/ml, get supernatant after leaving standstill 10h, get 1.72 kilograms of 3.44 kilograms of Borneolum Syntheticums and Mentholums and be dissolved in 17.2 kilograms of propylene glycol and RH
4017.2 in the kilogram, behind the mix homogeneously, obtain modulating solution, modulation solution is added in the supernatant of Chinese medicine extraction liquid, after stirring, namely get Chinese medicine antiseptic.
Embodiment 3:
Take by weighing Chinese medicine and raw material according to following weight:
Fructus Cnidii 27, Herba Hedyotidis Diffusae 27, Pericarpium Zanthoxyli 13, Herba Menthae 13, Radix Sophorae Flavescentis 13, the Radix Stemonae 13, Borneolum Syntheticum 4.24, Mentholum 2.12, RH
4020, propylene glycol 20.
The preparation method of Chinese medicine antiseptic:
Get 27 kilograms of Fructus Cnidiis, 27 kilograms of Herba Hedyotidis Diffusaes, 13 kilograms in Pericarpium Zanthoxyli, 13 kilograms of Herba Menthaes, 13 kilograms of Radix Sophorae Flavescentiss and 13 kilograms of Six-element Chinese medicines of the Radix Stemonae and put into container, give the water that adds 15 times of Chinese medicine gross weights in the container, heating and refluxing extraction 2h, filter, medicinal residues add the water of 10 times of Chinese medicine gross weights again, heating and refluxing extraction 2h, merge gained filtrate twice, filtrate after the merging is concentrated into 0.2g/ml, get supernatant after leaving standstill 11h, get 2.12 kilograms of 4.24 kilograms of Borneolum Syntheticums and Mentholums and be dissolved in 21.2 kilograms of propylene glycol and RH
4021.2 in the kilogram, behind the mix homogeneously, obtain modulating solution, modulation solution is added in the supernatant of Chinese medicine extraction liquid, after stirring, namely get Chinese medicine antiseptic.
Embodiment 4:
Take by weighing Chinese medicine and raw material according to following weight:
Fructus Cnidii 10, Herba Hedyotidis Diffusae 40, Pericarpium Zanthoxyli 5, Herba Menthae 20, Radix Sophorae Flavescentis 5, the Radix Stemonae 20, Borneolum Syntheticum 3, Mentholum 3, RH
4011, propylene glycol 20.
Preparation method such as embodiment 1.
Embodiment 5:
Take by weighing Chinese medicine and raw material according to following weight:
Fructus Cnidii 40, Herba Hedyotidis Diffusae 10, Pericarpium Zanthoxyli 20, Herba Menthae 5, Radix Sophorae Flavescentis 20, the Radix Stemonae 5, Borneolum Syntheticum 5, Mentholum 1, RH
4018, propylene glycol 10.
Preparation method such as embodiment 1.
Embodiment 6:
Take by weighing Chinese medicine and raw material according to following weight:
Fructus Cnidii 30, Herba Hedyotidis Diffusae 28, Pericarpium Zanthoxyli 15, Herba Menthae 14, Radix Sophorae Flavescentis 15, the Radix Stemonae 15, Borneolum Syntheticum 4, Mentholum 2, RH
4010, propylene glycol 10.
Preparation method such as embodiment 1.
The using method of the embodiment of the invention:
(1) Personal hygiene is with sterilizing: it is an amount of to get Chinese medicine antiseptic of the present invention, adds Chinese medicine antiseptic gross weight 10-50 water doubly and dilutes, and stirs, and dips with towel or cotton swab and carries out on a small quantity skin degerming or the nursing of other Personal hygiene, once a day.
(1) the house health is with sterilizing: it is an amount of to get Chinese medicine antiseptic of the present invention, adding water 10-20 doubly dilutes, stir, if be used for the medicated clothing sterilization, then medicated clothing can be soaked in the disinfectant, rub gently after several minutes, medicated clothing fully contacts rear clean with flushing with clean water with Chinese medicine antiseptic, squeezing, dry in the sun gets final product to dry; If be used for surface disinfection, such as desktop, ground etc. then should the disinfectant that dilution is good be sprayed on body surface, and disinfectant is fully contacted with body surface, drying the surface gets final product, be rag, mop etc. such as sterilised object, then should be with rag, mop equals fully to soak in the disinfectant, flushing with clean water is clean, dries to get final product.
Above-described embodiment, the present invention specific embodiment a kind of more preferably just, the common variation that those skilled in the art carries out in the technical solution of the present invention scope and replacing all should be included in protection scope of the present invention.
Claims (6)
1. one kind is used for the Chinese medicine antiseptic compositions, it is characterized in that, is comprised of following raw material: Fructus Cnidii, Herba Hedyotidis Diffusae, Pericarpium Zanthoxyli, Herba Menthae, Radix Sophorae Flavescentis, the Radix Stemonae, Borneolum Syntheticum, Mentholum, polyoxyethylene hydrogenated Oleum Ricini and propylene glycol.
2. as claimed in claim 1 for the Chinese medicine antiseptic compositions, it is characterized in that: the raw material by following weight portion forms: Fructus Cnidii 10-40 part, Herba Hedyotidis Diffusae 10-40 part, Pericarpium Zanthoxyli 5-20 part, Herba Menthae 5-20 part, Radix Sophorae Flavescentis 5-20 part, Radix Stemonae 5-20 part, Borneolum Syntheticum 3-5 part, Mentholum 1-3 part, polyoxyethylene hydrogenated Oleum Ricini 10-20 part, propylene glycol 10-20 part.
3. as claimed in claim 2 for the Chinese medicine antiseptic compositions, it is characterized in that: the raw material by following weight portion forms: Fructus Cnidii 10-30 part, Herba Hedyotidis Diffusae 10-30 part, Pericarpium Zanthoxyli 5-15 part, Herba Menthae 5-15 part, Radix Sophorae Flavescentis 5-15 part, Radix Stemonae 5-15 part, Borneolum Syntheticum 3-4 part, Mentholum 1-2 part, polyoxyethylene hydrogenated Oleum Ricini 10-16 part, propylene glycol 10-16 part.
4. as claimed in claim 3 for the Chinese medicine antiseptic compositions, it is characterized in that: the raw material by following weight portion forms: 20 parts of Fructus Cnidiis, 20 parts of Herba Hedyotidis Diffusaes, 10 parts in Pericarpium Zanthoxyli, 10 parts of Herba Menthaes, 10 parts of Radix Sophorae Flavescentiss, 10 parts of the Radixs Stemonae, 3.2 parts of Borneolum Syntheticums, 1.6 parts of Mentholums, 16 parts of polyoxyethylene hydrogenated Oleum Ricini, 16 parts of propylene glycol.
5. such as each described method for preparing Chinese medicine antiseptic for the Chinese medicine antiseptic compositions of claim 1-4, it is characterized in that: get the Chinese crude drug Fructus Cnidii, Herba Hedyotidis Diffusae, Pericarpium Zanthoxyli, Herba Menthae, Radix Sophorae Flavescentis and the Radix Stemonae are put into container, give and add Chinese medicine gross weight 10-15 water doubly in the container, heating and refluxing extraction 1.5-2h, filter, medicinal residues add Chinese medicine gross weight 7-10 water doubly again, heating and refluxing extraction 1.5-2h, merge gained filtrate twice, filtrate after the merging is concentrated into 0.2-0.3g/ml, get supernatant after leaving standstill 10-15h, get Borneolum Syntheticum and Mentholum and be dissolved in propylene glycol and the polyoxyethylene hydrogenated Oleum Ricini, behind the mix homogeneously, obtain modulating solution, modulation solution is added in the supernatant of Chinese medicine extraction liquid, after stirring, namely gets Chinese medicine antiseptic.
One kind in accordance with the method for claim 5 the preparation Chinese medicine antiseptic.
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| CN108208040A (en) * | 2018-02-07 | 2018-06-29 | 合肥华盖生物科技有限公司 | A kind of plant air disinfectant and preparation method thereof |
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