CN111514093A - Silver ion ethanol disinfectant and preparation method thereof - Google Patents
Silver ion ethanol disinfectant and preparation method thereof Download PDFInfo
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- CN111514093A CN111514093A CN202010417422.4A CN202010417422A CN111514093A CN 111514093 A CN111514093 A CN 111514093A CN 202010417422 A CN202010417422 A CN 202010417422A CN 111514093 A CN111514093 A CN 111514093A
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- pearl
- supernatant
- silver ion
- purified water
- ethanol
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 136
- 239000000645 desinfectant Substances 0.000 title claims abstract description 58
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 98
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 73
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 61
- 239000000413 hydrolysate Substances 0.000 claims abstract description 51
- 239000008213 purified water Substances 0.000 claims abstract description 51
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 49
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 41
- 229960001631 carbomer Drugs 0.000 claims abstract description 41
- 239000002994 raw material Substances 0.000 claims abstract description 28
- 230000001954 sterilising effect Effects 0.000 claims abstract description 27
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 18
- 239000001525 mentha piperita l. herb oil Substances 0.000 claims abstract description 13
- 235000019477 peppermint oil Nutrition 0.000 claims abstract description 13
- 108010009736 Protein Hydrolysates Proteins 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims description 49
- 239000000843 powder Substances 0.000 claims description 48
- 239000006228 supernatant Substances 0.000 claims description 48
- 239000012071 phase Substances 0.000 claims description 42
- 239000002244 precipitate Substances 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 31
- 238000009210 therapy by ultrasound Methods 0.000 claims description 22
- 239000003921 oil Substances 0.000 claims description 21
- 235000019198 oils Nutrition 0.000 claims description 21
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 14
- 244000293323 Cosmos caudatus Species 0.000 claims description 13
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 230000008961 swelling Effects 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
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- 206010029803 Nosocomial infection Diseases 0.000 abstract description 2
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- 239000000047 product Substances 0.000 description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 229910052709 silver Inorganic materials 0.000 description 8
- 239000004332 silver Substances 0.000 description 8
- -1 quaternary ammonium salt compounds Chemical class 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
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- 238000012360 testing method Methods 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
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- 238000001228 spectrum Methods 0.000 description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
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- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
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- 241000475481 Nebula Species 0.000 description 1
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- 241001212699 Pinctada martensii Species 0.000 description 1
- 229920000153 Povidone-iodine Polymers 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000003489 abdominal muscle Anatomy 0.000 description 1
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- 230000003115 biocidal effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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Abstract
The invention discloses a silver ion ethanol disinfectant, which is prepared from pearl hydrolysate, ethanol, silver nitrate, carbomer, triethanolamine, peppermint oil, glycerol and purified water. The invention also provides a preparation method of the silver ion ethanol disinfectant and pearl hydrolysate. The silver ion ethanol disinfectant has the advantages of wide application range, simple preparation method, wide raw material source and strong sterilization capability, can efficiently kill fungi and bacteria on the surface of skin, and reduces cross infection of bacteria between people and between people. Has no residual toxicity and no pollution, and has important significance for environmental protection. The pearl hydrolysate contains various amino acids and trace elements, has the effects of repairing human body skin cells, promoting cell metabolism, beautifying and health care, reducing the stimulation of ethanol to the skin, and improving the application level of biotechnology to the aspects of medicine and health.
Description
Technical Field
The invention relates to the technical field of chemical disinfectants, in particular to a silver ion ethanol disinfectant and a preparation method thereof.
Background
For many years, researchers at home and abroad carry out extensive screening on the disinfectant according to the disinfection purpose and the characteristics of a disinfection object, but an ideal chemical disinfectant is not found at present. The aldehyde, acid type abdominal muscle and alkylated gas disinfectant has wide bactericidal spectrum, but high toxicity and strong corrosivity. The chlorine preparation has low effective concentration, fast acting speed and stable property, but is easily influenced by organic matters, acid, alkali and other physical and chemical factors, and the 'three-cause' effect of the by-product of the chlorine preparation after the chlorine preparation disinfects drinking water and the irritation of the disinfection water after the dosage is increased to the organism.
Skin disinfectants are a class of agents that kill or eliminate pathogenic microorganisms that transmit the vehicle. Bacteria on the skin can be divided into transient bacteria and resident bacteria. Resident bacteria reside below the epithelial cells of the stratum corneum of the skin, and can also be found on the skin surface, of which staphylococcus epidermidis is one of the most important. The resident bacteria are planted on the skin cortex and are generally removed by ordinary hand washing. Transient bacteria do not normally multiply on the skin, but they survive and partially multiply on the skin surface. Transient bacteria are often contaminated by direct contact between the health care provider and the patient, or by contact with environmental surfaces in the vicinity of the patient, and are therefore closely associated with nosocomial infections.
The existing skin disinfectants are various, mainly comprise chemical disinfectants and traditional Chinese medicine disinfectants, and the chemical disinfectants widely used at present comprise alcohol, iodine, povidone iodine, hydrogen peroxide, boric acid, potassium permanganate, quaternary ammonium salt compounds and the like, but the disinfectants have high irritation and are easy to cause permanent damage to the skin.
The silver ion disinfectant is a non-toxic, tasteless, non-irritant and pollution-free 'green bactericidal product', and silver with a certain concentration has a killing effect on bacteria, viruses, fungi and the like. The silver ions have strong antibacterial ability and broad-spectrum antibacterial property, long lasting effect and good safety. Therefore, the coating is widely applied to plastics, ceramics, living goods, sanitary goods and textiles. However, the content of ethanol in the silver ion disinfectant is high, and the silver ion disinfectant has high stimulation to the skin when being used for disinfecting the skin of a human body.
The Margarita is prepared from the secretions of mantle of Pinctada martensii of Pinctada of Unionidae and Hyriopsis cumingii and Cristaria plicata of Cristaria of Unionidae after stimulation, and has the effects of tranquilizing mind, arresting convulsion, improving eyesight, eliminating pathogenic wind, removing toxic substance, and promoting granulation, and can be used for treating pavor, insomnia, convulsion, epilepsy, conjunctival congestion, nebula, and unhealed skin and external diseases. The curative effect of pearl is exactly recorded in the compendium of materia medica from the famous medical records of Han dynasty to the Ming dynasty. The pearl powder is rich in various proteins and keratin peptides, various amino acids, 24 trace elements, calcium and other effective components required by human bodies, has the effects of resisting fatigue and obviously reducing peroxide ester, thereby playing the roles of beautifying and protecting skin and delaying senility, and is often used as a raw material of high-grade tonic products and high-grade cosmetics. People have long used pearl powder to keep skin smooth and fine, but the main component of the pearl powder is calcium carbonate and other components are not easy to be absorbed by human body. Especially, conchiolin in Margarita is not easily decomposed and absorbed in vivo. Thus greatly hindering the positive effects of the pearl powder and its special functions.
Therefore, it is necessary to develop a silver ion disinfectant with good antibacterial effect, broad antibacterial spectrum and small irritation to skin.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a silver ion ethanol disinfectant.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the silver ion ethanol disinfectant comprises the following raw materials in percentage by mass:
1 to 5 percent of pearl hydrolysate, 60 to 70 percent of ethanol, 0.002 to 0.004 percent of silver nitrate, 0.1 to 0.5 percent of carbomer, 0.1 to 0.5 percent of triethanolamine, 0.05 to 0.2 percent of peppermint oil, 1 to 5 percent of glycerol and the balance of purified water.
Preferably, the material composition comprises the following raw materials in percentage by mass:
pearl hydrolysate 2%, ethanol 65%, silver nitrate 0.003%, carbomer 0.3%, triethanolamine 0.3%, peppermint oil 0.1%, glycerol 2%, and the balance of purified water.
The invention also provides a preparation method of the silver ion ethanol disinfectant, which comprises the following specific steps: (a1) adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swelled carbomer, and uniformly stirring to obtain a swelling solution as a water phase;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
Preferably, in step (a3), the aqueous phase is subjected to ultrasonic treatment in an ultrasonic treatment device, and the addition of the oil phase is completed within 30 min.
Preferably, when the aqueous phase is subjected to ultrasonic treatment, the power of the ultrasonic treatment device is controlled to be 100W-400W. The working time and the intermittent time are respectively 2s-5s and 5s-10 s.
Preferably, the aqueous phase (a1) and/or the oil phase (a2) can be respectively subjected to ultrasonic treatment and then mixed to prepare the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(b1) adding 3.5-6 times of 5-10% sulfuric acid into pearl powder, stirring, and removing bubbles;
(b2) placing the mixture obtained in the step (b1) in a damp-heat sterilization cabinet, hydrolyzing for 10-15 h under the pressure of not less than 0.1MPa, cooling, taking out, adjusting the pH value to be neutral by adopting hydrochloric acid with the concentration of 10%, and filtering to obtain filtrate;
(b3) concentrating the filtrate of step (b2) under reduced pressure until the filtrate and pearl powder have the same weight, and sterilizing to obtain Margarita hydrolysate.
Besides the acidolysis method for preparing the pearl hydrolysate, the invention also provides other methods for preparing the pearl hydrolysate, wherein one method comprises the following steps:
(c1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, and centrifuging to obtain precipitate;
(c2) adding purified water and an enzyme preparation into the precipitate obtained in the step (c1) for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, centrifuging after the enzymolysis is finished, taking supernate, concentrating the supernate under reduced pressure until the weight of the supernate is equal to that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
Preferably, the pearl hydrolysate is prepared by a method which comprises the following steps:
(d1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, centrifuging to obtain primary supernatant and primary precipitate, and adjusting pH of the primary supernatant to neutral;
(d2) adding purified water and an enzyme preparation into the primary precipitate for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, and centrifuging after the enzymolysis is finished to obtain secondary supernatant;
(d3) mixing the primary supernatant and the secondary supernatant, concentrating under reduced pressure until the weight of the mixed supernatant is 1-2 times of that of the pearl powder, and sterilizing to obtain pearl hydrolysate.
Preferably, the pearl hydrolysate is prepared by another method which comprises the following steps:
(e1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, centrifuging to obtain primary supernatant and primary precipitate, and adjusting pH of the primary supernatant to neutral;
(e2) adding purified water and an enzyme preparation into the primary precipitate for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, and centrifuging after the enzymolysis is finished to obtain a secondary supernatant and a secondary precipitate;
(e3) repeating step (e2) on the second precipitate to obtain a third precipitate and a third supernatant;
(e4) mixing the primary supernatant, the secondary supernatant and the tertiary supernatant, concentrating under reduced pressure until the weight of the mixed supernatant is 1-2 times of that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
Preferably, the enzyme preparation is any one of a trypsin solution, a papain solution and a keratinase solution.
Preferably, the dosage of the enzyme preparation is 0.08-0.15% of the mass of the pearl powder.
Preferably, the acidic solution is any one of sulfuric acid, hydrochloric acid, acetic acid, lactic acid, acetic acid and sodium acetate solution.
Preferably, the mass fraction of the acidic solution is 5% -10%.
Preferably, the mass ratio of the acid solution to the pearl powder is 2-4: 1.
Preferably, the pearl powder is any one of common pearl powder, superfine pearl powder and nano-scale pearl powder.
Due to the adoption of the technical scheme, the invention has the following beneficial effects:
1. the silver ions in the silver ion ethanol disinfectant have an oxidizing effect, can effectively kill fungi and bacteria on the surface of the skin, and is suitable for fungal infection on the surface of the skin. Has especially obvious killing effect on colibacillus and staphylococcus aureus. After the bacteria are killed by the silver ions, the silver ions are dissociated from the bacteria and then contact with other bacterial colonies, and the process is repeatedly carried out, so that the sterilizing effect of the silver is durable.
2. The silver ion ethanol disinfectant disclosed by the invention is thickened by carbomer and triethanolamine, so that the fluidity of the disinfectant is reduced, large-area flowing volatilization/splashing caused by wiping is avoided, the adhesion rate of silver ions on human skin is enhanced, the durability of antibiosis is enhanced, meanwhile, the contact time of the human skin and pearl hydrolysate is also increased, the skin is fully moistened, and the irritation of ethanol to the skin is reduced as much as possible.
3. The silver ion ethanol disinfectant also contains pearl hydrolysate which contains various amino acids, trace elements and other effective components, so that the silver ion ethanol disinfectant has a repairing effect on human body skin cells, promotes the metabolism of the cells and has the effects of beautifying and health care. The utilization rate of the effective components of the pearl powder is improved, thereby realizing the maximum value utilization of the pearl (powder) and simultaneously reducing the production cost.
In conclusion, the silver ion ethanol disinfectant has the advantages of wide application range, simple preparation method, wide raw material source and strong sterilization capability, and reduces the cross infection of bacteria between people and objects. The biological alcohol-based moisturizing cream has no residual toxicity and no pollution, has important significance for environmental protection, simultaneously moisturizes the skin of a human body, reduces the stimulation of ethanol to the skin, and improves the application level of biotechnology to the aspect of medicine and health.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below with reference to preferred embodiments. It should be noted, however, that the numerous details set forth in the description are merely for the purpose of providing the reader with a thorough understanding of one or more aspects of the present invention, which may be practiced without these specific details.
Example 1
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 2%, ethanol 65%, silver nitrate 0.003%, carbomer 0.3%, triethanolamine 0.3%, peppermint oil 0.1%, glycerol 2%, and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swelled carbomer, and uniformly stirring to obtain a swelling solution as a water phase;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(b1) adding 4 times of 5% sulfuric acid into Margarita powder, stirring, and removing bubbles;
(b2) placing the mixture obtained in the step (b1) in a damp-heat sterilization cabinet, hydrolyzing for 15h under the pressure of 0.1MPa and at the environmental temperature of 120 ℃, cooling, taking out, adjusting the pH value to be neutral by adopting hydrochloric acid with the concentration of 10%, and filtering to obtain filtrate;
(b3) concentrating the filtrate of step (b2) under 0.1MPa to equal weight of filtrate and Margarita powder, and sterilizing to obtain Margarita hydrolysate.
Example 2
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: 1% of pearl hydrolysate, 61% of ethanol, 0.002% of silver nitrate, 0.1% of carbomer, 0.1% of triethanolamine, 0.2% of peppermint oil, 5% of glycerol and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swollen carbomer, uniformly stirring to obtain a swelling solution as a water phase, and treating the swelling solution in an ultrasonic treatment device for 5min, wherein the power of the ultrasonic treatment device is 100W, and the working time and the intermittent time are respectively 2s and 5 s;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(b1) adding sulfuric acid with the mass fraction of 10% in an amount which is 3.5 times that of the superfine pearl powder into the superfine pearl powder, and uniformly stirring until bubbles are eliminated;
(b2) placing the mixture obtained in the step (b1) in a damp-heat sterilization cabinet, hydrolyzing for 15h under the pressure of 0.12MPa, cooling, taking out, adjusting the pH value to be neutral by adopting hydrochloric acid with the concentration of 10%, and filtering to obtain filtrate;
(b3) concentrating the filtrate of step (b2) under 0.08MPa to equal weight of filtrate and Margarita powder, and sterilizing to obtain Margarita hydrolysate.
Example 3
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 1.5%, ethanol 62%, silver nitrate 0.004%, carbomer 0.2%, triethanolamine 0.2%, peppermint oil 0.15%, glycerin 4.5%, and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swollen carbomer, uniformly stirring to obtain a swelling solution as a water phase, and treating for 2min in an ultrasonic treatment device with the power of 200W and the working time and the intermittent time of 5s and 10s respectively;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(c1) adding 10% by mass of lactic acid solution into nanometer pearl powder at a mass ratio of 1:2, performing acidolysis until no bubbles are generated, and centrifuging to obtain precipitate;
(c2) adding purified water and trypsin solution which accounts for 0.08 percent of the mass of the nano-scale pearl powder into the precipitate obtained in the step (c1) for enzymolysis, controlling the enzymolysis temperature at 59 ℃, the pH at 6.0 and the time at 20 hours, centrifuging after the enzymolysis is finished, taking supernate, concentrating the supernate under the pressure of 0.07MPa until the weight of the supernate is equal to that of the nano-scale pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
Example 4
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 2.5%, ethanol 63%, silver nitrate 0.004%, carbomer 0.4%, triethanolamine 0.4%, peppermint oil 0.05%, glycerin 4%, and purified water in balance.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swollen carbomer, uniformly stirring to obtain a swelling solution as a water phase, and treating the swelling solution in an ultrasonic treatment device for 10min, wherein the power of the ultrasonic treatment device is 150W, and the working time and the intermittent time are respectively 20s and 40 s;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, stirring to obtain mixed solution as oil phase, treating in ultrasonic treatment device with power of 100W for 10min, and working time and interval time of 5s and 15s respectively;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(c1) adding 5% acetic acid solution into pearl powder at a mass ratio of 1:4, performing acidolysis until no bubbles are generated, and centrifuging to obtain precipitate;
(c2) and (c1) adding purified water and papain liquid accounting for 0.1% of the mass of the pearl powder into the precipitate obtained in the step (c1) for enzymolysis, controlling the enzymolysis temperature at 62 ℃, the pH at 7.0 and the time at 16h, centrifuging after the enzymolysis is finished, taking supernate, concentrating the supernate under the pressure of 0.09MPa until the weight of the supernate is equal to that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
Example 5
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 3%, ethanol 64%, silver nitrate 0.003%, carbomer 0.5%, triethanolamine 0.5%, peppermint oil 0.08%, glycerin 3.5%, and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swelled carbomer, and uniformly stirring to obtain a swelling solution as a water phase;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) placing the water phase (a1) in an ultrasonic treatment device for treatment, wherein the power of the ultrasonic treatment device is 100W, the working time and the intermittent time are respectively 2s and 5s, adding the oil phase (a2) into the water phase (a1) in a trickle manner while stirring, and finishing the addition within 30min to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(d1) adding 8% sulfuric acid into superfine pearl powder at a mass ratio of 1:2.5, performing acidolysis until no bubbles are generated, and centrifuging to obtain primary supernatant and primary precipitate, wherein the pH value of the primary supernatant is adjusted to be neutral;
(d2) adding purified water and 0.12% of keratinase solution of superfine Margarita powder into the primary precipitate, performing enzymolysis at 60 deg.C and pH 6.5 for 17 hr, and centrifuging to obtain secondary supernatant;
(d3) mixing the primary supernatant and the secondary supernatant, concentrating under 0.1MPa until the weight of the mixed supernatant is 1.5 times of that of the superfine Margarita powder, and sterilizing to obtain Margarita hydrolysate.
Example 6
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 3%, ethanol 66%, silver nitrate 0.002%, carbomer 0.2%, triethanolamine 0.2%, peppermint oil 0.12%, glycerin 3%, and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swelled carbomer, and uniformly stirring to obtain a swelling solution as a water phase;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) placing the water phase (a1) in an ultrasonic treatment device for treatment, wherein the power of the ultrasonic treatment device is 400W, the working time and the intermittent time are respectively 5s and 10s, adding the oil phase (a2) into the water phase (a1) in a trickle manner while stirring, and finishing the addition within 15min to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(d1) adding 7% hydrochloric acid into superfine pearl powder at a mass ratio of 1:3.8, performing acidolysis until no bubbles are generated, and centrifuging to obtain primary supernatant and primary precipitate, wherein the pH value of the primary supernatant is adjusted to be neutral;
(d2) adding purified water and trypsin solution 0.09% of the superfine pearl powder into the primary precipitate for enzymolysis, controlling the enzymolysis temperature at 61 deg.C, pH at 6.8, and time at 18 hr, and centrifuging to obtain secondary supernatant;
(d3) mixing the primary supernatant and the secondary supernatant, concentrating under 0.08MPa until the weight of the mixed supernatant is 2 times of that of the superfine pearl powder, and sterilizing to obtain pearl hydrolysate.
Example 7
The silver ion ethanol disinfectant comprises the following raw materials in percentage by mass: pearl hydrolysate 3%, ethanol 70%, silver nitrate 0.003%, carbomer 0.3%, triethanolamine 0.3%, peppermint oil 0.18%, glycerol 1%, and the balance of purified water.
The preparation method comprises the following steps:
(a1) weighing the raw materials in proportion, adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swollen carbomer, uniformly stirring to obtain a swelling solution which is a water phase, and treating the swelling solution in an ultrasonic treatment device for 3min at the treatment power of 250W;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) placing the water phase (a1) in an ultrasonic treatment device for treatment, wherein the power of the ultrasonic treatment device is 300W, the working time and the intermittent time are respectively 3s and 7s, adding the oil phase (a2) into the water phase (a1) in a trickle manner while stirring, and finishing the addition within 20min to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
The preparation method of the pearl hydrolysate comprises the following steps:
(e1) adding 10% sulfuric acid solution into nanometer pearl powder at a mass ratio of 1:4, performing acidolysis until no bubbles are generated, centrifuging to obtain primary supernatant and primary precipitate, and adjusting pH of the primary supernatant to neutral;
(e2) adding purified water and 0.11% of keratinase solution of superfine Margarita powder into the primary precipitate for enzymolysis at 62 deg.C and pH 6.9 for 19 hr, and centrifuging to obtain secondary supernatant and secondary precipitate;
(e3) repeating step (e2) on the second precipitate to obtain a third precipitate and a third supernatant;
(e4) mixing the primary supernatant, the secondary supernatant and the tertiary supernatant, concentrating under the pressure of 0.09MPa until the weight of the mixed supernatant is 1.8 times of that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
The pearl hydrolysate and purified water adopted in all the above examples reach medicinal grade, ethanol is food grade, and silver nitrate, carbomer, triethanolamine, peppermint oil and glycerin are all chemically pure.
Test of sterilizing Effect
In order to verify the sterilization effect of the disinfectant, researchers of the invention respectively carry out sterilization tests on staphylococcus aureus, coliform bacteria, pseudomonas aeruginosa and candida albicans by using the products of the examples according to the specification of sterilization technical Specification (2002 edition), and the table 1 shows the sterilization effect of the products of the example 1.
TABLE 1
As shown in Table 1, the products of the examples of the present invention have a good effect of killing microorganisms in the table.
Sensory, physicochemical and hygienic indexes
The present inventors examined the products of the examples of the present invention as specified in the "Disinfection Specification" (2002 edition). The mercury, arsenic and lead contents were measured according to the regulations of technical Specifications for cosmetic safety (2015 edition). The results are shown in Table 2.
TABLE 2
As shown in table 2, the product of the embodiment of the present invention has extremely low content of mercury, arsenic, lead, etc., does not affect human skin, is stable, does not delaminate, has no precipitate or suspended matter, is a colloidal liquid, is not easy to spill when in use, and has sufficient residence time on skin. Has no odor, and does not irritate eyes and respiratory tract of human body.
In addition, researchers of the invention also carry out acute oral toxicity tests and multiple complete skin irritation tests according to the regulations of disinfection technical specifications (2002 edition), and the results show that the product of the invention is actually nontoxic, has no irritation or slight irritation to the skin and is safe to use. Meets the requirements of on-site skin disinfection, on-site sanitary hand disinfection and on-site surgical hand disinfection.
Stability test
The product of the embodiment is placed in a constant temperature box with the temperature of 37 +/-2 ℃ for 90 days, the content of ethanol and silver in the disinfectant is respectively measured before and after the product is placed, and the result reduction rate is less than or equal to 10 percent. Meanwhile, the disinfectant has no color change, no precipitate or no suspended matters, which shows that the product of the invention has good stability, storage resistance and long-distance transportation.
Claims (9)
1. The silver ion ethanol disinfectant is characterized by comprising the following raw materials in percentage by mass:
1 to 5 percent of pearl hydrolysate, 60 to 70 percent of ethanol, 0.002 to 0.004 percent of silver nitrate, 0.1 to 0.5 percent of carbomer, 0.1 to 0.5 percent of triethanolamine, 0.05 to 0.2 percent of peppermint oil, 1 to 5 percent of glycerol and the balance of purified water.
2. The silver ion ethanol disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in percentage by mass:
pearl hydrolysate 2%, ethanol 65%, silver nitrate 0.003%, carbomer 0.3%, triethanolamine 0.3%, peppermint oil 0.1%, glycerol 2%, and the balance of purified water.
3. The silver ion ethanol disinfectant as set forth in claim 1 or 2, characterized in that it is prepared by the following method:
(a1) adding a proper amount of purified water into carbomer to fully swell the carbomer; adding silver nitrate into the purified water to dissolve the silver nitrate to obtain a silver nitrate solution; adding silver nitrate solution, pearl hydrolysate and residual purified water into the swelled carbomer, and uniformly stirring to obtain a swelling solution as a water phase;
(a2) adding oleum Menthae Dementholatum, glycerol and triethanolamine into ethanol, and stirring to obtain mixed solution as oil phase;
(a3) and (b) adding the oil phase (a2) into the water phase (a1) in a trickle manner, and fully and uniformly stirring to obtain colloidal liquid, namely the silver ion ethanol disinfectant.
4. The silver ion ethanol disinfectant as set forth in claim 3, wherein in the step (a3), the aqueous phase is placed in an ultrasonic treatment device to be subjected to ultrasonic treatment, and the addition of the oil phase is completed within 30 min.
5. The silver ion ethanol disinfectant as set forth in claim 4, wherein the power of the ultrasonic treatment device is controlled to be 100W-400W when the aqueous phase is subjected to ultrasonic treatment. The working time and the intermittent time are respectively 2s-5s and 5s-10 s.
6. The silver ion ethanol disinfectant as set forth in claim 1 or 2, wherein the pearl hydrolysate is prepared by the following method:
(b1) adding 3.5-6 times of 5-10% sulfuric acid into pearl powder, stirring, and removing bubbles;
(b2) placing the mixture obtained in the step (b1) in a damp-heat sterilization cabinet, hydrolyzing for 10-15 h under the pressure of not less than 0.1MPa, cooling, taking out, adjusting the pH value to be neutral by adopting hydrochloric acid with the concentration of 10%, and filtering to obtain filtrate;
(b3) concentrating the filtrate of step (b2) under reduced pressure until the filtrate and pearl powder have the same weight, and sterilizing to obtain Margarita hydrolysate.
7. The silver ion ethanol disinfectant as set forth in claim 1 or 2, wherein the pearl hydrolysate is prepared by the following method:
(c1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, and centrifuging to obtain precipitate;
(c2) adding purified water and an enzyme preparation into the precipitate obtained in the step (c1) for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, centrifuging after the enzymolysis is finished, taking supernate, concentrating the supernate under reduced pressure until the weight of the supernate is equal to that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
8. The silver ion ethanol disinfectant as set forth in claim 1 or 2, wherein the pearl hydrolysate is prepared by the following method:
(d1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, centrifuging to obtain primary supernatant and primary precipitate, and adjusting pH of the primary supernatant to neutral;
(d2) adding purified water and an enzyme preparation into the primary precipitate for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, and centrifuging after the enzymolysis is finished to obtain secondary supernatant;
(d3) mixing the primary supernatant and the secondary supernatant, concentrating under reduced pressure until the weight of the mixed supernatant is 1-2 times of that of the pearl powder, and sterilizing to obtain pearl hydrolysate.
9. The silver ion ethanol disinfectant as set forth in claim 1 or 2, wherein the pearl hydrolysate is prepared by the following method:
(e1) adding acid solution into pearl powder, performing acidolysis until no bubbles are generated, centrifuging to obtain primary supernatant and primary precipitate, and adjusting pH of the primary supernatant to neutral;
(e2) adding purified water and an enzyme preparation into the primary precipitate for enzymolysis, controlling the enzymolysis temperature to be 59-62 ℃, the pH to be 6.0-7.0 and the time to be 16-20 h, and centrifuging after the enzymolysis is finished to obtain a secondary supernatant and a secondary precipitate;
(e3) repeating step (e2) on the second precipitate to obtain a third precipitate and a third supernatant;
(e4) mixing the primary supernatant, the secondary supernatant and the tertiary supernatant, concentrating under reduced pressure until the weight of the mixed supernatant is 1-2 times of that of the pearl powder raw material, and sterilizing to obtain pearl hydrolysate.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956665A (en) * | 2020-08-19 | 2020-11-20 | 白燕波 | Electrolytic silver ion disinfectant and preparation method thereof |
| CN114224914A (en) * | 2021-11-10 | 2022-03-25 | 惠州华阳医疗器械有限公司 | Antimicrobial composition and preparation method thereof |
| EP4032403A1 (en) | 2021-01-20 | 2022-07-27 | Galaxy Surfactants Ltd. | Safe and ecofriendly persistent sanitizing gel for topical application |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046283A (en) * | 1989-02-02 | 1990-10-24 | 吴霭春 | Water-soluble pearl-layer powder |
| CN102626421A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Silver ion antimicrobial gel and preparation method thereof |
| CN104257583A (en) * | 2014-09-19 | 2015-01-07 | 上海荣神生物化学有限公司 | Pearl enzymolysis solution and preparation method thereof |
| CN107898732A (en) * | 2017-12-29 | 2018-04-13 | 无限极（中国）有限公司 | It is a kind of that there is whitening, the composition and its application, skin care item of light spot effect |
| CN108158936A (en) * | 2018-02-09 | 2018-06-15 | 广西北海苗康生物科技有限公司 | A kind of blue or green money willow pearl skin care liquid and preparation method |
| CN108553571A (en) * | 2018-06-19 | 2018-09-21 | 山东柯尔杰卫生科技有限公司 | One kind is based on pure plant extraction type skin antiseptic and preparation method thereof |
-
2020
- 2020-05-18 CN CN202010417422.4A patent/CN111514093A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1046283A (en) * | 1989-02-02 | 1990-10-24 | 吴霭春 | Water-soluble pearl-layer powder |
| CN102626421A (en) * | 2012-05-04 | 2012-08-08 | 江西中兴汉方药业有限公司 | Silver ion antimicrobial gel and preparation method thereof |
| CN104257583A (en) * | 2014-09-19 | 2015-01-07 | 上海荣神生物化学有限公司 | Pearl enzymolysis solution and preparation method thereof |
| CN107898732A (en) * | 2017-12-29 | 2018-04-13 | 无限极（中国）有限公司 | It is a kind of that there is whitening, the composition and its application, skin care item of light spot effect |
| CN108158936A (en) * | 2018-02-09 | 2018-06-15 | 广西北海苗康生物科技有限公司 | A kind of blue or green money willow pearl skin care liquid and preparation method |
| CN108553571A (en) * | 2018-06-19 | 2018-09-21 | 山东柯尔杰卫生科技有限公司 | One kind is based on pure plant extraction type skin antiseptic and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨万慧: "《四川省水利地方电力水产科技成果汇编》", 31 December 1988 * |
| 董志华: "水溶性珍珠粉不同制备工艺比较研究", 《湖南中医药导报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111956665A (en) * | 2020-08-19 | 2020-11-20 | 白燕波 | Electrolytic silver ion disinfectant and preparation method thereof |
| EP4032403A1 (en) | 2021-01-20 | 2022-07-27 | Galaxy Surfactants Ltd. | Safe and ecofriendly persistent sanitizing gel for topical application |
| US12109283B2 (en) | 2021-01-20 | 2024-10-08 | Galaxy Surfactants Ltd. | Safe and ecofriendly persistent sanitizing gel for topical application |
| CN114224914A (en) * | 2021-11-10 | 2022-03-25 | 惠州华阳医疗器械有限公司 | Antimicrobial composition and preparation method thereof |
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