CN110711263A

CN110711263A - Functional dressing with functions of preventing, repairing and modifying scars and preparation method thereof

Info

Publication number: CN110711263A
Application number: CN201911217264.1A
Authority: CN
Inventors: 张明; 周新钦; 刘津梦; 曹晶晶; 杨帅; 张建鑫; 王川; 石锐; 郑豪; 李果
Original assignee: Henan Huibo Medical Co Ltd
Current assignee: Henan Huibo Medical Co Ltd
Priority date: 2019-12-03
Filing date: 2019-12-03
Publication date: 2020-01-21

Abstract

The invention discloses a functional dressing with the functions of preventing, repairing and modifying scars, which is characterized by comprising the following raw materials in percentage by mass: 20-40% of polydimethylsiloxane, 0.1-1% of aloe extract, 0.1-1% of centella asiatica extract, 0.1-1% of prunus persica leaf extract, 0.1-0.5% of 3-O-ethyl ascorbic acid, 1-5% of emulsifier, 5-15% of glycerol, 20-50% of purified water, 0.1-1% of foundation, 1-5% of isododecane, 1-10% of ethanol, 1-10% of electrolyzed water, 1-10% of titanium oxide and 1-5% of zinc oxide. The aloe extract, the centella extract and the prunus persica leaf extract are added to have synergistic effect, so that the generation of black precipitates is inhibited, scars are softened from water supply, and the existing chromaticity is reduced. The invention selects natural plant extracts: the aloe extract, the centella extract and the prunus persica leaf extract are combined with each other to form hydrophilic groups, and the plant extracts belong to small molecules, can fully and effectively permeate into the surface layer of skin, cannot cause sensitization, and can play good antibacterial, whitening and moisturizing roles.

Description

Functional dressing with functions of preventing, repairing and modifying scars and preparation method thereof

Technical Field

The invention relates to a functional dressing, in particular to a functional dressing with the functions of preventing, repairing and modifying scars and a preparation method thereof.

Background

Scars are physical, biochemical and other reasons, which cause serious injury of skin and soft tissues of human bodies, can not be completely and normally repaired, and are replaced by fibrous tissues, so that local symptoms which influence functions and appearance are remained. When the growth of the scar exceeds a certain limit, various complications such as disfigurement and dysfunction of functional activities can be generated, great physical and mental pains can be brought to patients, especially the scar left after burn, scald and serious trauma is difficult to eliminate without taking measures. The period of several years during the scar hyperplastic phase is almost overwhelming for the patient. The later atrophy period causes the patients to have complete facial disabilities and dysfunction, thus causing great physical and psychological damage to the patients. With the progress of society, beauty not only represents one right, but also represents a respect to the self, scars are one of the most common problems in the outpatient department of cosmetic plastic surgery, besides appearance influence, in fact, a lot of scars can cause uncomfortable itching, pain and chapping, and if the scars are unfortunately atrophied, the activities of joints of four limbs or the normal functions of five sense organs can be further influenced, and the scars need to be actively prevented and treated. At present, most of the silicone gel prepared from single polysiloxane according to different proportions is used for preventing and treating scars in the market, the formula is single, the function is single, the repair effect of the product on the scars is only passive water locking, the scar repair effect is not ideal, and the scar modification effect is lacked.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide the functional dressing with the functions of preventing, repairing and modifying scars, and the dressing has better effects of sterilizing, moisturizing and whitening.

The second purpose of the invention is to provide a preparation method of the functional dressing with the functions of preventing, repairing and modifying scars.

One of the purposes of the invention is realized by adopting the following technical scheme:

a functional dressing with the functions of preventing, repairing and modifying scars comprises the following raw materials in percentage by mass: 20-40% of polydimethylsiloxane, 0.1-1% of aloe extract, 0.1-1% of centella asiatica extract, 0.1-1% of prunus persica leaf extract, 0.1-0.5% of 3-O-ethyl ascorbic acid, 1-5% of emulsifier, 5-15% of glycerol, 20-50% of purified water, 0.1-1% of foundation, 1-5% of isododecane, 1-10% of ethanol, 1-10% of electrolyzed water, 1-10% of titanium oxide and 1-5% of zinc oxide.

Further, the aloe extract is aloe tincture, the centella asiatica extract is asiaticoside, and the prunus persica leaf extract is oleamide.

Further, the foundation comprises the following raw materials in percentage by mass: 5-30% of talcum powder, 1-10% of kaolin, 5-30% of titanium dioxide, 5-20% of zinc stearate, 5-30% of pearl powder and 1-10% of ferric oxide.

The second purpose of the invention is realized by adopting the following technical scheme:

the preparation method of the functional dressing with the functions of preventing, repairing and modifying scars comprises the following steps:

(1) preparing an oil phase: mixing polydimethylsiloxane and an emulsifier to prepare an oil phase;

(2) preparing an aqueous phase: mixing aloe extract, herba Centellae extract, folium Actinidiae chinensis extract, 3-O-ethyl ascorbic acid, glycerol, purified water, foundation, isododecane, ethanol, electrolyzed water, titanium oxide, and zinc oxide to obtain water phase;

(3) and (3) mixing the oil phase obtained in the step (1) and the water phase obtained in the step (2) for homogenization, and cooling to room temperature to obtain the product.

Further, the step (1) comprises placing polydimethylsiloxane and emulsifier into an oil phase tank of a vacuum homogenizing emulsifying machine, heating to 80-90 ℃ under the condition of stirring speed of 10-20/min, and keeping the temperature at 80-90 ℃ for 10-20min to obtain an oil phase.

Further, the step (2) comprises placing the raw materials for preparing the water phase into a water phase tank of a vacuum homogenizing emulsifying machine, heating to 80-90 deg.C while stirring, and maintaining for 10-20min to obtain the water phase.

Further, in the step (3), the mixture is homogenized at 95-100kPa for 500-800 s.

Compared with the prior art, the invention has the beneficial effects that:

1. the functional dressing with the functions of preventing, repairing and modifying scars is added with the aloe extract, the centella extract and the prunus persica leaf extract for synergistic action, on one hand, the aloe extract forms a moisturizing film on the surface of skin, the centella extract and the 3-O-ethyl ascorbic acid in the moisturizing film can effectively inhibit the generation of tyrosinase, thereby preventing melanin from precipitating, and radically reducing the color of scars, on the other hand, the moisture in the moisturizing film can soften scars by continuously supplying water to damaged barriers, and the scar pigments are reduced, the prunus persica leaf extract in the moisturizing film can effectively reduce the cell damage caused by the generation of active oxygen and free radicals in the skin, thereby avoiding sunburn and aging of scar parts, thereby effectively preventing the increase of the color of scars, inhibiting the generation of black precipitates, and softening scars from full moisture retention, the existing chromaticity is lightened. The invention selects natural plant extracts: the aloe extract, the centella asiatica extract and the prunus persica leaf extract are different from chemical components used in the market, the plant extracts are natural and efficient, no side effect exists, and the plant extracts belong to small molecules.

2. The functional dressing with the functions of preventing, repairing and modifying scars is added with the aloe extract and the electrolyzed water for matching use, so that the short-time bacterial killing effect of the product is improved, the sterilization aging is effectively prolonged, and the stability of system components is kept. The electric potential water is used for replacing sodium hydroxybenzoate preservative which is frequently selected in the prior art, and cannot cause any damage to the skin with very fragile scars.

3. According to the functional dressing with the functions of preventing, repairing and modifying scars, the sunscreens such as titanium oxide and zinc oxide are added, physical sunscreen and chemical sunscreen are combined, the titanium oxide can completely block UVB, but only UVA with a short wavelength can be blocked, the zinc oxide can block ultraviolet rays according to the principle of absorption and scattering, UVA and UVB with all wavelengths can be almost blocked, the safety is high, the scar skin is protected through double sunscreen effects, and the pigmentation of the scar skin is prevented.

4. The functional dressing with the functions of preventing, repairing and modifying scars is added with the foundation make-up component, so that the silicone gel foundation make-up has the effect of effectively covering scars, and the scar skin is not different from normal skin after being coated, so that people with scar skin can go out without worrying about the burn of outdoor ultraviolet rays to the damaged scar skin and the increase of pigmentation after the scar skin is coated, and the aloe extract and the powder bottom are fused to form water-soluble liquid, so that the dressing has better skin application performance, the foundation make-up is more naturally applied, and on the other hand, aloe forms a layer of moisturizing film on the surface of the skin to serve as a barrier for the damaged skin at the scar.

5. The functional dressing with the functions of preventing, repairing and modifying scars is also added with 3-O-ethyl ascorbic acid, isododecane and ethanol, so that the product is fresh and cool in texture, not greasy and easy to apply, and the interaction of the 3-O-ethyl ascorbic acid and the isododecane can achieve the effects of whitening scars and preventing scars from being secondarily damaged by ultraviolet rays.

Detailed Description

The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.

Example 1

A functional dressing with the functions of preventing, repairing and modifying scars is prepared from the following raw materials in percentage by mass: 20% of polydimethylsiloxane, 0.5% of aloe tincture, 0.5% of asiaticoside, 0.5% of almond folic acid amide, 0.5% of 3-O-ethyl ascorbic acid, 5% of emulsifier, 15% of glycerol, 30% of purified water, 1% of foundation make-up, 5% of isododecane, 5% of ethanol, 5% of electrolyzed water, 7% of titanium oxide and 5% of zinc oxide.

The foundation make-up comprises the following raw materials in percentage by mass: 20% of talcum powder, 10% of kaolin, 20% of titanium dioxide, 20% of zinc stearate, 20% of pearl powder and 10% of ferric oxide.

(1) preparing an oil phase: putting polydimethylsiloxane and an emulsifier into an oil phase tank of a vacuum homogenizing emulsifying machine, heating to 80 ℃ under the condition that the stirring speed is 10/min, and keeping the temperature at 80 ℃ for 10min to obtain an oil phase;

(2) preparing an aqueous phase: placing Aloe extract, herba Centellae extract, folium Actinidiae chinensis extract, 3-O-ethyl ascorbic acid, glycerol, purified water, foundation, isododecane, ethanol, electrolyzed water, titanium oxide, and zinc oxide into water phase tank of vacuum homogenizing emulsifying machine, heating to 80 deg.C while stirring, and maintaining for 10min to obtain water phase;

(3) homogenizing the oil phase in the step (1) and the water phase in the step (2) for 500s under 100kPa, and cooling to room temperature to obtain the product.

Example 2

A functional dressing with the functions of preventing, repairing and modifying scars is prepared from the following raw materials in percentage by mass: 30% of polydimethylsiloxane, 0.7% of aloe tincture, 0.8% of asiaticoside, 0.4% of almond folic acid amide, 0.4% of 3-O-ethyl ascorbic acid, 2% of emulsifier, 10% of glycerol, 21% of purified water, 0.7% of foundation make-up, 3% of isododecane, 8% of ethanol, 10% of electrolyzed water, 10% of titanium oxide and 3% of zinc oxide.

The foundation make-up comprises the following raw materials in percentage by mass: 5% of talcum powder, 10% of kaolin, 30% of titanium dioxide, 20% of zinc stearate, 30% of pearl powder and 5% of ferric oxide.

(1) preparing an oil phase: putting polydimethylsiloxane and an emulsifier into an oil phase tank of a vacuum homogenizing emulsifying machine, heating to 85 ℃ under the condition that the stirring speed is 15/min, and keeping the temperature at 85 ℃ for 15min to obtain an oil phase;

(2) preparing an aqueous phase: placing Aloe extract, herba Centellae extract, folium Actinidiae chinensis extract, 3-O-ethyl ascorbic acid, glycerol, purified water, foundation, isododecane, ethanol, electrolyzed water, titanium oxide, and zinc oxide into water phase tank of vacuum homogenizing emulsifying machine, heating to 85 deg.C under stirring, and maintaining for 15min to obtain water phase;

(3) homogenizing the oil phase in the step (1) and the water phase in the step (2) for 700s under 98kPa, and cooling to room temperature to obtain the product.

Example 3

A functional dressing with the functions of preventing, repairing and modifying scars is prepared from the following raw materials in percentage by mass: 40% of polydimethylsiloxane, 0.1% of aloe tincture, 0.1% of asiaticoside, 0.1% of almond folic acid amide, 0.1% of 3-O-ethyl ascorbic acid, 2% of emulsifier, 5% of glycerol, 46% of purified water, 0.6% of foundation make-up, 1% of isododecane, 1% of ethanol, 1% of electrolyzed water, 2% of titanium oxide and 1% of zinc oxide.

The foundation make-up comprises the following raw materials in percentage by mass: 30% of talcum powder, 10% of kaolin, 20% of titanium dioxide, 5% of zinc stearate, 30% of pearl powder and 5% of ferric oxide.

(1) preparing an oil phase: putting polydimethylsiloxane and an emulsifier into an oil phase tank of a vacuum homogenizing emulsifying machine, heating to 90 ℃ under the condition that the stirring speed is 20/min, and keeping the temperature at 90 ℃ for 20min to obtain an oil phase;

(2) preparing an aqueous phase: placing Aloe extract, herba Centellae extract, folium Actinidiae chinensis extract, 3-O-ethyl ascorbic acid, glycerol, purified water, foundation, isododecane, ethanol, electrolyzed water, titanium oxide, and zinc oxide into water phase tank of vacuum homogenizing emulsifying machine, heating to 90 deg.C while stirring, and maintaining for 20min to obtain water phase;

(3) homogenizing the oil phase in the step (1) and the water phase in the step (2) for 800s under 100kPa, and cooling to room temperature to obtain the product.

Comparative example 1

Comparative example 1 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: the oleanolic acid amide and asiaticoside are omitted, and the total amount of aloe tincture is adjusted to 1.5 parts.

Comparative example 2

Comparative example 2 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: aloe tincture and almond folic acid amide are omitted, and the total dosage of asiaticoside is adjusted to 1.5 parts.

Comparative example 3

Comparative example 3 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: aloe tincture and asiaticoside are omitted, and the total amount of almond folic acid amide is regulated to 1.5 weight portions.

Comparative example 4

Comparative example 4 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: the oleanolic acid amide is omitted, and the total dosage of aloe tincture and asiaticoside is adjusted to 1.5 parts.

Comparative example 5

Comparative example 5 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: aloe tincture is omitted, and the total amount of asiaticoside and almond folic acid amide is regulated to 1.5 weight portions.

Comparative example 6

Comparative example 6 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: asiaticoside is omitted, and the total amount of aloe tincture and almond folic acid amide is regulated to 1.5 parts.

Comparative example 7

Comparative example 7 provides a functional dressing having the effects of preventing, repairing and modifying scars, which is different from example 1 in that: the potential water was replaced with sodium methyl hydroxybenzoate.

Test examples

1. Test of bacteriostatic Effect

Preparing a liquid medicine: the products of example 1, comparative examples 1 to 7 were prepared in a concentration of 1g/L in sterilized distilled water and placed in stainless steel vials, respectively.

Prepare a "concentration" of test bacterial suspension: staphylococcus aureus, Escherichia coli and Candida albicans were selected for this experiment. Pouring 10mL of sterile water on the cultured strain, gently scraping the planar spore suspension by using an inoculating needle, pouring the planar spore suspension into a sterile triangular flask (filled with a plurality of glass beads in advance), shaking for 5min, and filtering the spore suspension into another sterile triangular flask by using a sterile double-layer gauze. The spore concentration was adjusted by low power (15X 20 times) microscopy, which should be performed under sterile conditions. 10mL of sterilized clear agar medium contained in a test tube was dissolved, poured into a 9 cm-diameter petri dish while it was hot, and horizontally condensed. Melting 100mL of culture medium suitable for the growth and development of the test bacteria, cooling to 45-50 ℃, quickly sucking 10mL of bacteria liquid, adding the bacteria liquid, horizontally condensing. 10mL of bacterial liquid is quickly absorbed and added into the stainless steel small tube (the liquid medicine is added to the tube opening to form a convex surface), after a certain period of culture, the liquid medicine is taken out and used for measuring the diameter of a bacteriostatic zone by a cross method, and the bacteriostatic activity of each group is evaluated according to the existence and the size of the bacteriostatic zone, and the results are shown in Table 1.

2. Test of whitening Effect

Testing objects and processing: randomly selecting 100 volunteers, and drawing eight blocks of 1 × 1cm on the left and right forearm flexor sides of each volunteer²The test area of the left arm is coated with the samples of example 1 and comparative examples 1 to 7, and the test area of the right arm is empty self-control, and the 100 volunteers are allowed to coat once a day for 30 consecutive days. Due to human beingThe skin color mainly depends on the content of melanin and heme (haematochrome) in human skin, so the whitening effect of the skin care product can be obtained by testing the variation of the melanin and the heme in the skin, the content of the melanin and the heme in the skin can be directly measured by adopting a Janus-1 skin tester of Korean LG, wherein the measurement range of the tester is 0-999, the higher the measurement value is, the higher the content of the melanin and the heme in the skin is, the content of the melanin and the heme in the front and back left arms and the content of the melanin and the haematochrome in the right arm of 100 experimenters are tested, the average values (taking integers) are respectively calculated, and the result is shown in Table 1.

3. Test of moisturizing Effect

The test object is treated according to the same method of the whitening effect test, and the moisture content in the skin surface layer can basically reflect the moisturizing effect of the product, so that the higher the moisture content is, the better the moisturizing effect is. The moisture content of the test area of the left and right arm of each experimenter was measured using Corneometer CM825 tester, and the test was repeated 5 times for each experimenter to take an average value, and then 100 volunteers were taken an average value, and the results are shown in table 1.

TABLE 1

As can be seen from table 1, the product of example 1 is superior to the products of comparative examples 1 to 7 in bacteriostasis, whitening and moisturizing properties, and after one or two of aloe tincture, asiaticoside and almond folic acid amide are omitted in comparative examples 1 to 6, the product of the present invention is inferior to the product of example 1 in bacteriostasis, whitening and moisturizing properties, so that the product of the present invention can effectively prevent scars by exerting bacteriostasis and effectively prevent melanin precipitation by adding aloe tincture, asiaticoside and almond folic acid amide to act synergistically, and can radically reduce scar chromaticity, and has good moisturizing properties, and can continuously supply water to damaged barriers to soften scars and reduce scar pigments. In comparative example 7, the performance of the product is deteriorated after the electric potential water is replaced by sodium hydroxybenzoate, because the electric potential water is added to be matched with the aloe extract, on one hand, the short-time bacterial killing effect of the product is increased, on the other hand, the sterilization time is effectively prolonged, and a layer of moisturizing film is formed on the surface of human skin to continuously supply water to the damaged skin barrier, so that the scar is softened, and the color of the scar is reduced. The potential water is used for replacing sodium methyl hydroxybenzoate, and the damage to the wounded skin which is very fragile per se can not be caused.

The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.

Claims

1. A functional dressing with the functions of preventing, repairing and modifying scars is characterized by comprising the following raw materials in percentage by mass: 20-40% of polydimethylsiloxane, 0.1-1% of aloe extract, 0.1-1% of centella asiatica extract, 0.1-1% of prunus persica leaf extract, 0.1-0.5% of 3-O-ethyl ascorbic acid, 1-5% of emulsifier, 5-15% of glycerol, 20-50% of purified water, 0.1-1% of foundation, 1-5% of isododecane, 1-10% of ethanol, 1-10% of electrolyzed water, 1-10% of titanium oxide and 1-5% of zinc oxide.

2. The functional dressing with scar control, repair and modification functions of claim 1, wherein the aloe vera extract is aloe vera tincture, the centella asiatica extract is asiaticoside, and the prunus persica leaf extract is oleamide.

3. The functional dressing with the effects of preventing, repairing and modifying scars according to claim 1, wherein the foundation comprises the following raw materials in percentage by mass: 5-30% of talcum powder, 1-10% of kaolin, 5-30% of titanium dioxide, 5-20% of zinc stearate, 5-30% of pearl powder and 1-10% of ferric oxide.

4. The preparation method of the functional dressing with the functions of preventing, repairing and modifying scars as claimed in any one of claims 1 to 3, is characterized by comprising the following steps:

5. The method for preparing a functional dressing with the effects of preventing, repairing and modifying scars according to claim 4, wherein the step (1) comprises the steps of putting polydimethylsiloxane and an emulsifying agent into an oil phase tank of a vacuum homogenizing emulsifying machine, heating to 80-90 ℃ under the condition that the stirring speed is 10-20/min, and keeping the temperature at 80-90 ℃ for 10-20min to obtain the oil phase.

6. The method for preparing a functional dressing with effects of preventing, repairing and modifying scar according to claim 4, wherein the step (2) comprises placing the raw materials for preparing the water phase into the water phase tank of a vacuum homogenizing emulsifying machine, heating to 80-90 ℃ while stirring, and keeping for 10-20min to obtain the water phase.

7. The method for preparing a functional dressing with the functions of preventing, repairing and modifying scars as claimed in claim 4, wherein the step (3) is performed by homogenizing for 500-800s at 95-100 kPa.