CN1810256A - Policresulen foam aerosol and its prepn process - Google Patents

Abstract

The present invention discloses one kind of policresulen foam aerosol. The policresulen foam aerosol has softness, fineness, no excitation, excellent adsorption, excellent expansion and other advantages, can penetrate to mucous membrane goffer and other parts common medicine preparation can not reach to, and is suitable for use in body cavity. Clinic application shows that the policresulen foam aerosol is superior to corresponding spraying agent in treating cervicitis and vaginitis. The present invention also provides its preparation process.

Description

Policresulen foam aerosol and preparation technology

Technical field

The present invention relates to pharmaceutical preparation, relate in particular to a kind of policresulen foam aerosol and preparation technology.

Background technology

Policresulen is the local topical medicine.It mainly act as: (1) can optionally act on epithelial cell and the ectopic columnar epithelium that pathological changes takes place, and makes it to solidify, degeneration, comes off, and promote tissue repair, and normal squamous cell is not had influence, does not stay cicatrix after the treatment cervical erosion.(2) recovery of environment in the promotion vagina physiology helps growing again of indigneous flora.(3) can shrink little blood vessel, rapidly hemostasis.(4) can kill multiple pathogenic microorganism, as antibacterial, mycete, infusorian and some virus.Clinical being used for (1) gynecological, increase vaginitis, cervicitis by antibacterial, infusorian, the microbial vagina of beads and cervical secretions; Cervical biopsy or polyp are extractd the treatment of postoperative hemorrhage; (2) surgery and department of dermatologry: the topical therapeutic of skin injury can promote regeneration, antiinflammatory and the healing of slough.

Policresulen is suppository and concentrated solution and spray in gynecological's dosage form commonly used at present, suppository is solid preparation, softening in tract, dissolving is slower, onset is slower, and medicine disperses inhomogeneous, local concentration is higher, simultaneously, need be manipulation when medication, not only unhygienic but also easy cross-contamination, in patient's body foreign body sensation is arranged, bring discomfort to the patient.Concentrated solution need be used cotton balls wiping or dilute with water afterflush when administration, medicine can not fully contact with the tract mucosa, and liquid flows the same inconvenience of use easily in tract.Though the spray that with water is solvent can directly be sprayed at partial wound, the aerosol spray granularity is big, should not go deep into tract mucosa wrinkle wall, and administration is inhomogeneous, influences circulation, makes troubles to the patient.

Washing liquid adopts washout, interior spray in use, but time of contact is short; Can not go deep into the intravaginal lesions position during washout, not have therapeutic effect; Can not fully act on focus, DeGrain during interior the spray.

Suppository is because of the holdup time long (6-8 hour) and to absorb intravaginal moisture zest strong, for recurrence hides some dangers for, but also produce dry and astringent, discomfort such as foreign body sensation, destructible acid-base balance arranged.

These dosage forms produce certain influence to the use of policresulen.

Summary of the invention

Technical problem to be solved by this invention is to overcome the defective of above-mentioned preparation, and the dosage form that research design is new is evenly distributed medicine, better effects if in tract.

The invention provides a kind of policresulen foam aerosol, this aerosol is made up of following component, by weight percentage.

Principal agent: policresulen 1%-40%

Pharmaceutic adjuvant: pH regulator agent 0%-5.0%, foaming agent 0.2%-30%, foam substrate 0%-30%, foam stabiliser 0%-15%, spice 0%-0.5%, solvent 40%-90%, antioxidant 0%-0.5%, antiseptic 0%-0.2%, propellant 3%-40%.

The described pharmaceutic adjuvant of this aerosol comprises: pH regulator agent, foaming agent, foam substrate, foam stabiliser, spice, solvent, antioxidant, antiseptic, propellant etc.

PH value regulator amount ranges 0.000-5.000% (w/w): as sodium hydroxide, sodium bicarbonate, sodium phosphate, sodium citrate etc.;

Foaming agent, foam substrate can adopt surfactant, and its amount ranges 0.200-30.000% (w/w) can be non-ionic surface active agent, anion surfactant, cationic surfactant, amphoteric surfactant or other surfactant;

Available nonionic surfactants, as:

The fatty acid esters of sorbitan class, as: Arlacel-20, Arlacel-60, Arlacel-65, Arlacel-80, Arlacel-85 etc.;

Polyethylene glycols, as: PEG-200, PEG-400, PEG-600, PEG-1000 etc.;

The polyoxyethylene sorbitan fatty acid ester class, as: tween 20, Tween-40, Tween-60, Tween-65, tween 80 etc.;

The polyoxyethylene alkyl ether class, as: Brij30, polyoxyethylene stearyl alcohol ether etc.;

The polyoxyethylene fatty acid ester class, as: Myij-45, Myij-52, Myij-53, Myij-59 etc.;

The polyol-based non-ionic surfactant class, as: glycerol monolaurate, sorbitol lauric acid monoesters etc.;

Available anion surfactant class, as:

The sulfuric ester salt, as: sodium lauryl sulphate, polyoxyethylene lauryl alcohol sodium sulfovinate, glycerol monolaurate sodium sulfate etc.;

The higher fatty acids salt, as: sodium stearate, zinc stearate, aluminium distearate, 12 imido dipropionic acids, the inferior oxygen base of Adeps Bovis seu Bubali disodium beclomethasone, sodium laurate, enuatrol etc.;

Sulfonates, as: dodecylbenzene sodium sulfonate, succinate sodium sulfonate etc.;

Fatty acyl-peptide condensation substance class, as: sodium lauroyl sarcosine, oleoyl glycyl replace propylhomoserin sodium etc.;

Available cationic surfactant class, as:

Amine salt type cationic surfactant class, as: triethanolamine, triethanolamine stearate, Palmic acid triethanolamine etc.;

The quaternary ammonium salt cationic surfactant class, as: dodecyl front three ammonia chloride,

Dodecyl dimethyl benzyl ammonia chloride, myristoyl Propylamino dimethyl benzyl ammonia chloride etc.;

Available amphoteric surfactant class, as:

The amino acid type amphoteric surface active agent class: as: dodecyl base sodium propionate etc.;

Betaine type amphoteric surfac-tant's class: as: dodecyl dimethyl tertiary amine etc.;

Amine oxide type amphoteric surfactant class: as: alkyl dimethyl amine oxide, alkyl diethyl alcohol radical amine oxide etc.;

It is available that other is surfactant-based, as:

Aminoacid is surfactant-based, as: N-lauroyl glutamic acid dibutyl amide etc.;

The high molecular surfactant class, as: natural Sodium Alginate, pectic acid sodium etc.;

Semisynthetic sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose etc.;

Synthetic polyvinylpyrrolidone, polyvinyl alcohol, polyvinylether, polyacrylamide, polyoxyethylene-polyoxypropylene etc.;

The biosurfactant class: as: tragacanth, arabic gum, gelatin, agar, sodium alginate, pectin, apricot glue, agar, lecithin etc.;

Foam substrate also can adopt higher hydrocarbon, higher fatty acids, and high fatty alcohol, higher fatty acids fat etc., amount ranges 0.000-30.000% (w/w), as:

Higher hydrocarbons, as: liquid paraffin, vaseline etc.;

The higher fatty acids class, as: myristic acid, stearic acid, Palmic acid etc.;

The high fatty alcohol class, as: octadecanol, hexadecanol etc.;

Higher fatty acids lipid, as: tristerin, Oleum Ricini, vegetable oil, isopropyl myristate, Cera Flava, lanoline etc.;

Foam stabiliser amount ranges 0.000-15.000% (w/w), as: tetrapotassium pyrophosphate, glycerol, agar, karaya, triethanolamine oleate, dioctyl sodium sulphosuccinate, Palmic acid trimethyl-ethylene amine, polyvinylpyrrolidone etc.;

Essence amount ranges 0.000-0.500% (w/w), as: all kinds of essence such as Herba Menthae essence, jasmin essence etc.;

Antiseptic amount ranges 0.000-0.200% (w/w), as: sodium benzoate, potassium sorbate, methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben, etc.;

Antioxidant amount ranges 0.000-0.500% (w/w) as: ethylenediaminetetraacetic acid, disodium EDTA, butyl hydroxy toluene, sodium sulfite, sodium pyrosulfite, potassium metabisulfite, vitamin C, vitamin E, beta-carotene, etc.;

Solvent load 40.000-90.000% (w/w), as: distilled water, glycerol, propylene glycol, ethanol etc.;

Propellant can be one or more blended chlorofluoromethane hydrocarbons and compressibility gas etc., its amount ranges 3.000-40.000% (w/w), as:

The chlorofluoromethane hydro carbons, as: isceon, dichlorodifluoromethane, dichlorotetra-fluoroethane, chlorodifluoroethane etc., or not chloride tetrafluoroethane, Difluoroethane etc.;

Hydrocarbon, as: iso-butane, propane etc.;

The compressibility gas, as: dimethyl ether, carbon dioxide, nitrogen, carbon dioxide etc.;

Medicine of the present invention shows through Mount Taishan hospital clinical observed result: cervicitis is treated in the policresulen foam aerosol, vaginitis is better than the spray effect.Concrete clinical test results is as follows:

1. material and method

1.1 case is selected and grouping

According to the principle of clinical design, adopt the method for contrast at random to study, respectively case is divided into corresponding treatment group and matched group with table of random number.Each 50 example of cervicitis patient wherein, age 25-45 year; Each 44 example of trichomonal vaginitis, age 23-48 year, each 46 example of colpitis mycotica, age 25-47 year, each 40 example of bacterial vaginitis, age 22-50 year.

1.2 Therapeutic Method:

(1) treatment group: adopt policresulen foam aerosol of the present invention; Specification: 15% (g/g), 35g/ bottle, each administration 0.7g, twice weekly.

Matched group: adopt the self-control Policresulen spraying agent, specification: 10% (g/g), the medication number of times is with policresulen foam aerosol group.

2. result

The total effective rate of policresulen foam aerosol group is than matched group height, and difference has statistical significance (P＜0.01).

Grouping	Case load	Case load	Curative effect				Cure rate
								Recovery from illness	Produce effects	Effectively	Invalid
			The treatment group	Cervicitis	50	40						7	2	1	80％
Trichomonal vaginitis	44	31					6	5	2	70％
				Colpitis mycotica	46	39					5	2	0	85％
Bacterial vaginitis	40	32					4	3	1	80％
				Matched group	Cervicitis	50					20	2	22	6	40％
Trichomonal vaginitis	44	16	6				21	1	36％
					Colpitis mycotica	46				19	9	16	2	41％
Bacterial vaginitis	40	22	8				8	2	55％

Conclusion: policresulen foam aerosol treatment cervicitis, various vaginitis curative effect cure rate are significantly higher than the self-control Policresulen spraying agent, may can fully contact with tract mucosa and wrinkle wall in tract with foam aerosol, and the medicinal liquid holdup time is long relevant.Product of the present invention be a kind of collect imitate excellent, effect is fast, toxic and side effects novel gynecological external use medicine little, easy to use.

Another object of the present invention has provided a kind of preparation technology of policresulen foam aerosol, and this technology comprises the following steps:

(1) the policresulen raw material stirring is dissolved in one or more mixed solvents of distilled water, glycerol, propylene glycol or ethanol;

(2) add foaming agent, foam substrate, foam stabiliser, spice, antioxidant and antiseptic, stir and make its mix homogeneously;

(3) add the pH value regulator, the pH value of regulator solution is to 4-7.

(4) check the policresulen content of preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into propellant and get final product.

Perhaps:

(1) solution A: take by weighing foaming agent (particularly being insoluble in water), foam stabiliser, antiseptic, antioxidant and foam substrate and mix, water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, standby;

(2) solution B: the policresulen raw material is dissolved in the water of formula ratio 80%, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence, pH value regulator, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, the propellant that charges into recipe quantity gets final product.

Policresulen foam aerosol of the present invention has overcome the defective of solid preparation such as suppository and liquid preparation, and the foam form can make medicine be evenly distributed in tract, is coated with widely, and use feeling is more comfortable than spray simultaneously, and anelasticity is stronger than spray.And the technology content of foam aerosol is than spray with high content of technology that draws medicinal liquid by valve that with water is unique solvent, and it is more accurate to measure.Aerosol and spray contrast, because used propellant, not to promote by valve, but make particle diameter have only several microns droplet to become cystose to disperse by pressure, medicine can effectively arrive rapidly and infiltrate tract mucosa wrinkle wall, medicine is that the spray of unique solvent is faster at the auxiliary absorptance down of various fat-soluble adjuvants with water, use does not have drug contamination and cross-contamination, have curative effect fully, use hygienic and convenient, safe and reliable, no foreign body sensation, the patient is easy to accept and medicine is stablized, drug dose discharges accurately, and effect duration is long.

The specific embodiment

One, contains chlorofluoromethane hydro carbons aerosol

Embodiment 1

Component: weight: (%)

Policresulen 15.000

Sodium hydroxide 0.025

Tween-40 2.000

Sodium lauryl sulphate 4.000

Dioctyl sodium sulphosuccinate 0.100

Essence 0.025

Sodium pyrosulfite 0.020

Water 68.830

Dichlorodifluoromethane 10.000

Method:

(1) solution A: take by weighing Tween-40 20g, sodium lauryl sulphate 40g, dioctyl sodium sulphosuccinate 1g, sodium pyrosulfite 0.2g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 150g is dissolved in the 550g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium hydroxide 0.25g, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into the 100g dichlorodifluoromethane and get final product.

Embodiment 2

Component: weight: (%)

Policresulen 15.000

Sodium bicarbonate 0.035

Triethanolamine 1.000

Stearic acid 3.000

Essence 0.025

Glycerol 5.000

Ethyl hydroxybenzoate 0.150

Vitamin E 0.100

Water 63.690

Dichlorotetra-fluoroethane 4.000

Dichlorodifluoromethane 8.000

Method:

(1) solution A: take by weighing triethanolamine 10g, hard ester acid 30g, glycerol 50g, ethyl hydroxybenzoate 1.5g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 150g is dissolved in the 510g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium bicarbonate 0.35g, vitamin e1 .0g adds water to full dose, stirs;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into the 40g dichlorotetra-fluoroethane, the 80g dichlorodifluoromethane gets final product.

Embodiment 3

Component: weight: (%)

Policresulen 10.000

Sodium hydroxide 0.020

Palmic acid triethanolamine 3.000

Lanoline 0.200

Stearic acid 5.000

PVP 0.500

Essence 0.025

Propylparaben 0.100

Disodium EDTA 0.100

Water 69.955

Dichlorodifluoromethane 12.000

Method:

(1) solution A: take by weighing Palmic acid triethanolamine 30g, lanoline 2g, stearic acid 50g, PVP 5g, propylparaben 1g, disodium EDTA 1g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 100g is dissolved in the 560g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium hydroxide 0.20g, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into the 120g dichlorodifluoromethane and get final product.

Two, do not contain chlorofluoromethane hydro carbons aerosol

Embodiment 4

Component: weight: (%)

Policresulen 15.000

Sodium citrate 0.050

Tween-40 5.000

Arlacel-80 2.000

Dodecyl sodium sulfate 5.000

Essence 0.025

Water 44.925

Glycerol 20.000

Tetrafluoroethane 8.000

Method:

(1) solution A: take by weighing Tween-40 50g, Arlacel-80 20g, dodecyl sodium sulfate 50g, glycerol 200g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 150g is dissolved in the 360.25g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium citrate 0.5g, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into the 80g tetrafluoroethane and get final product.

Embodiment 5

Component: weight: (%)

Policresulen 15.000

Sodium hydroxide 0.025

Myij-45 4.000

Sodium lauryl sulphate 3.000

Essence 0.025

Water 59.950

Glycerol 10.000

Nitrogen 8.000

Method:

(1) solution A: take by weighing Myij-4540g, sodium lauryl sulphate 30g, glycerol 100g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 150g is dissolved in the 480g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium hydroxide 0.25g, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into 80g nitrogen and get final product.

Embodiment 6

Component: weight: (%)

Policresulen 15.000

Sodium hydroxide 0.025

Tween 80 5.000

Essence 0.025

Water 64.950

Glycerol 5.000

Propane 6.000

Iso-butane 4.000

Method:

(1) solution A: take by weighing tween 80 50g, glycerol 50g mixes, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: policresulen raw material 150g is dissolved in the 520g water, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence 0.25g, sodium hydroxide 0.25g, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into 60g propane, the 40g iso-butane gets final product.

Claims (8)

1. policresulen foam aerosol is characterized in that this foam aerosol is made up of following component, by weight percentage:

Principal agent: policresulen 1%-40%

Pharmaceutic adjuvant: pH regulator agent 0%-5.0%, foaming agent 0.2%-30%, foam substrate 0%-30%, foam stabiliser 0%-15%, spice 0%-0.5%, solvent 40%-90%, antioxidant 0%-0.5%, antiseptic 0%-0.2%, propellant 3%-40%.

2. a kind of policresulen foam aerosol according to claim 1 is characterized in that wherein said pharmaceutic adjuvant foaming agent and foam substrate are non-ionic surface active agent, anion surfactant, cationic surfactant, amphoteric surfactant or other surfactant.

3. pharmaceutic adjuvant foaming agent in the policresulen foam aerosol according to claim 2 and foam substrate is characterized in that wherein said non-ionic surface active agent is: fatty acid esters of sorbitan: Arlacel-20, Arlacel-60, Arlacel-65, Arlacel-80 or Arlacel-85; Polyethylene glycol type: PEG-200, PEG-400, PEG-600 or PEG-1000; Polyoxyethylene sorbitan fatty acid ester: tween 20, Tween-40, Tween-60, Tween-65 or tween 80; Polyoxyethylene alkyl ether: Brij30 or polyoxyethylene stearyl alcohol ether; Polyoxyethylene fatty acid ester: Myij-45, Myij-52, Myij-53 or Myij-59; Polyol-based non-ionic surfactant: glycerol monolaurate or sorbitol lauric acid monoesters; The anion surfactant of selecting for use is: sulfuric acid: sodium lauryl sulphate, polyoxyethylene lauryl alcohol sodium sulfovinate or glycerol monolaurate sodium sulfate; Higher fatty acid salt: sodium stearate, zinc stearate, aluminium distearate, 12 imido dipropionic acids, the inferior oxygen base of Adeps Bovis seu Bubali disodium beclomethasone, sodium laurate or enuatrol; Sulfonate: dodecylbenzene sodium sulfonate or succinate sodium sulfonate; Fatty acyl-peptide condensation substance: sodium lauroyl sarcosine or oleoyl glycyl are for propylhomoserin sodium; The cationic surfactant of selecting for use is: amine salt type cationic surfactant: triethanolamine, triethanolamine stearate or Palmic acid triethanolamine; Quaternary ammonium salt cationic surfactant: dodecyl front three ammonia chloride, dodecyl dimethyl benzyl ammonia chloride or myristoyl Propylamino dimethyl benzyl ammonia chloride; The amphoteric surfactant of selecting for use is: amino acid type amphoteric surface active agent: dodecyl base sodium propionate; Betaine type amphoteric surfac-tant: dodecyl dimethyl tertiary amine; Amine oxide type amphoteric surfactant: alkyl dimethyl amine oxide or alkyl diethyl alcohol radical amine oxide; Other surfactant of selecting for use: aminoacid is surfactant: N-lauroyl glutamic acid dibutyl amide; High molecular surfactant: natural Sodium Alginate or pectic acid sodium; Semisynthetic sodium carboxymethyl cellulose, methylcellulose or hydroxyethyl-cellulose; Synthetic polyvinylpyrrolidone, polyvinyl alcohol, polyvinylether, polyacrylamide or polyoxyethylene-polyoxypropylene; Biosurfactant: tragacanth, arabic gum, gelatin, agar, sodium alginate, pectin, apricot glue, agar or lecithin; Foam substrate also can adopt higher hydrocarbon, higher fatty acids, high fatty alcohol or higher fatty acids fat, higher hydrocarbon: liquid paraffin or vaseline; Higher fatty acids: myristic acid, stearic acid or Palmic acid; High fatty alcohol: octadecanol or hexadecanol; Higher fatty acids fat: tristerin, Oleum Ricini, vegetable oil, isopropyl myristate, Cera Flava or lanoline.

4. a kind of policresulen foam aerosol according to claim 1 is characterized in that wherein said foam stabiliser is tetrapotassium pyrophosphate, glycerol, agar, karaya, triethanolamine oleate, dioctyl sodium sulphosuccinate, Palmic acid trimethyl-ethylene amine or polyvinylpyrrolidone.

5. a kind of policresulen foam aerosol according to claim 1 is characterized in that wherein said essence is Herba Menthae essence or jasmin essence; Antiseptic is sodium benzoate, potassium sorbate, methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben or butoben; Antioxidant is ethylenediaminetetraacetic acid, disodium EDTA, butyl hydroxy toluene, sodium sulfite, sodium pyrosulfite, potassium metabisulfite, vitamin C, vitamin E or beta-carotene; Solvent is distilled water, glycerol, propylene glycol or ethanol.

6. a kind of policresulen foam aerosol according to claim 1 is characterized in that wherein said propellant is one or more blended chlorofluoromethane hydrocarbon and compressibility gases: chlorofluoro-alkane: isceon, dichlorodifluoromethane, dichlorotetra-fluoroethane or chlorodifluoroethane; Or not chloride tetrafluoroethane or Difluoroethane; Hydrocarbon: iso-butane or propane; Compressibility gas: dimethyl ether, carbon dioxide, nitrogen or carbon dioxide.

7. the preparation technology of a policresulen foam aerosol is characterized in that this technology comprises the following steps:

(1) the policresulen raw material stirring is dissolved in one or more mixed solvents of distilled water, glycerol, propylene glycol or ethanol;

(2) add foaming agent, foam substrate, foam stabiliser, spice, antioxidant and antiseptic, stir and make its mix homogeneously;

(3) add the pH value regulator, the pH value of regulator solution is to 4-7;

(4) check the policresulen content of preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, charge into propellant and get final product.

8. the preparation technology of a policresulen foam aerosol is characterized in that this technology comprises the following steps:

(1) solution A: take by weighing foaming agent, the foaming agent, foam stabiliser, antiseptic, antioxidant and the foam substrate that particularly are insoluble in water are mixed, and water-bath or slow fire are heated to and dissolve 60-70 ℃, mix, and is standby;

(2) solution B: the policresulen raw material is dissolved in the water of formula ratio 80%, and slowly is heated to the temperature of solution A; And solution A slowly added in the solution B while hot, stir while adding, make into emulsion;

When (3) emulsion temperature is reduced to below 40 ℃, add essence, pH value regulator, add water to full dose, stir;

(4) check policresulen content in the preparating liquid, medicinal liquid is poured in the pressure vessel, add cap valve and sealing, the propellant that charges into recipe quantity gets final product.