CN1803185A - Compound zedoary turmeric oil gelata and its preparing method - Google Patents
Compound zedoary turmeric oil gelata and its preparing method Download PDFInfo
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- CN1803185A CN1803185A CN 200510031138 CN200510031138A CN1803185A CN 1803185 A CN1803185 A CN 1803185A CN 200510031138 CN200510031138 CN 200510031138 CN 200510031138 A CN200510031138 A CN 200510031138A CN 1803185 A CN1803185 A CN 1803185A
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Abstract
The invention relates to a compound aromatic turmeric oil gelling agent and its preparing process, wherein each 1000g of the preparation comprises econazole nitrate 12.5g, oil of aromatic turmeric 52.5ml, gel base material 1-30g. The constituents also include sodium hydroxide, propylene glycol, ethanol, polysorbate -80, sorbic acid, sodium metabisulfite, vitamin E and deionized water. The gel base material is the mixture of carbome, sodium carboxymethylcellulose and sodium alginate.
Description
Technical field
The present invention relates to a kind of compound zedoary turmeric oil gelata and preparation method thereof, be used for the treatment of the novel pharmaceutical formulation of diseases such as vaginitis, cervical erosion, specifically the compound zedoary oil suppository that former Chinese Pharmacopoeia is recorded is changed into the preparation method of gel and said preparation.
Background technology
Disease such as female vagina, cervical erosion is commonly encountered diseases, frequently-occurring disease, has brought many miseries to the patient, has had a strong impact on the healthy of numerous women.One of the normal at present Therapeutic Method that uses and medicine of use are the compound zedoary oil suppository made from Oleum Curcumae.But character volatile, frowzy that Oleum Curcumae itself has makes it make curative effect subtract mistake owing to volatilization or oxidation Decomposition in depositing process, and its unpleasant stink also brought inconvenience to the patient, and suppository melts the back and easily flows out simultaneously, produces excessive.
Summary of the invention
Technical problem to be solved by this invention is at above-mentioned weak point of the prior art, provides a kind of treatment extensive, and instant effect not only takes stopgap measures but also effect a permanent cure, and the long-term storage drug effect does not subtract mistake and do not have compound zedoary turmeric oil gelata of bad smell and preparation method thereof.
Solve technical scheme that the technology of the present invention problem adopted and be this compound zedoary turmeric oil gelata in the preparation of 1000g, ingredient comprises:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Gel-type vehicle 1～30g
Gel-type vehicle is one or more the mixed gel substrate in carbopol, sodium carboxymethyl cellulose (CMC-Na), the sodium alginate.
Also comprise sodium hydroxide, propylene glycol, ethanol, Tween-80, sorbic acid, sodium pyrosulfite, vitamin E and deionized water in the compound zedoary turmeric oil gelata composition provided by the invention, therefore, in the preparation of compound zedoary turmeric oil gelata 1000g of the present invention, the composition proportion scope is:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Gel-type vehicle 1～30g
Sodium hydroxide 0～4g
Propylene glycol 10～50g
Ethanol 20～100g
Tween-80 10～50g
Sorbic acid 1～4g
Sodium pyrosulfite 0.5～2g
Vitamin E 0.5-2g
Deionized water adds to full dose
Make 1000g, can be sub-packed in 250 medicinal aluminum pipes every 4g.
In the said components, adjuvant: sodium hydroxide is the pH regulator agent, if uncomfortable then not molding of gel; Propylene glycol is solubilizing agent, wetting agent; Ethanol is solubilizing agent, the substrate dispersant; Tween-80 is an emulsifying agent; Sorbic acid is an antiseptic; Sodium pyrosulfite is an antioxidant; Vitamin E is an antioxidant; Deionized water is a substrate swelling material.
The preparation method of compound zedoary turmeric oil gelata of the present invention may further comprise the steps:
1, get the gel-type vehicle of proportional quantity, moistening with propylene glycol, add an amount of distilled water, make abundant swelling, or add sodium hydroxide with an amount of dissolved in distilled water, stir, get colorless transparent gel substrate;
2, get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirs, and makes it to be emulsified into milky O/W type emulsion;
3, get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, the sodium pyrosulfite water dissolution;
4, the econazole nitrate porphyrize of proportional quantity is crossed 80 mesh sieves;
5, respectively 2,3,4 step gains are joined in the gel-type vehicle of step 1, adding distil water stirs to 1000g;
6, placement made abundant swelling in 10-36 hour, stir, and packing, promptly.
The present invention adopts the bonded mode of Chinese medicine and western medicine, is main component with Oleum Curcumae, econazole nitrate etc., cooperates with other adjuvants, makes gel.Propylene glycol is a wetting agent, also is solubilizing agent, the stabilizing agent of liposoluble constituent simultaneously; Ethanol is solubilizing agent, the emulsifying agent of liposoluble constituent, also helps gel and forms, and also be antiseptic simultaneously; Tween-80 is the solubilizing agent of liposoluble constituent, also is the emulsifying agent that Oleum Curcumae becomes breast; Sorbic acid is an antiseptic; Sodium hydroxide works pH, the effect of adjusting gel consistency regulated; Sodium pyrosulfite, vitamin E are antioxidant, prevent the Oleum Curcumae oxidation deterioration; Deionized water dispersion medicine and substrate are convenient to medicine dissolution and substrate swelling.Compare with former preparation suppository, preparation stabilization, the curative effect height, do not have bad abnormal smells from the patient, the convenient use produces bioadhesion with uterus or vaginal mucosa, gel is adhered in the tract, good in the intravaginal anelasticity, so drug treating time is long, nonirritant, no foreign body sensation, medicine is difficult for flowing out because of the effect of bioadhesive material, the excessive generation of no suppository has strengthened curative effect, simultaneously, these bioadhesive material in vivo all can biodegradation, noresidue and toxic and side effects, the convenient use, thereby strengthened curative effect and patient's compliance.Simultaneously, the present invention adopts emulsifying process that Oleum Curcumae in the prescription is carried out emulsifying, has increased Oleum Curcumae stability, has reduced the unpleasant stink of Oleum Curcumae, to the external curing of diseases such as vaginitis, cervical erosion, is a kind of good dosage form.
The specific embodiment
When compound zedoary turmeric oil gelata of the present invention is selected different gel-type vehicles for use, in the preparation of 1000g, its gel-type vehicle consumption is respectively: when a kind of gel-type vehicle uses separately: carbopol is 1～20g, and sodium carboxymethyl cellulose (CMC-Na) is 10～30g, and sodium alginate is 10～30g; Two kinds of gel-type vehicles mix when using: as carbopol 1～5g and CMC-Na5～15g.
Below be non-limiting examples of the present invention:
Embodiment 1:
Per 1000 gram compound zedoary turmeric oil gelata preparations take by weighing material by following prescription:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Carbopol 15g
Sodium hydroxide 3g
Propylene glycol 25g
Ethanol 50g
Tween-80 25g
Sorbic acid 2g
Sodium pyrosulfite 0.5g
Vitamin E 0.5g
Deionized water adds to full dose
The raw material that takes by weighing is prepared compound zedoary turmeric oil gelata of the present invention according to the following steps:
1, card taking POP, moistening with propylene glycol, add an amount of distilled water, make abundant swelling, add sodium hydroxide with an amount of dissolved in distilled water, stir, get water white transparency carbopol substrate;
2, get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirs, and makes it to be emulsified into milky O/W type emulsion;
3, get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, the sodium pyrosulfite water dissolution;
4, the econazole nitrate porphyrize is crossed 80 mesh sieves;
5, respectively 2,3,4 step gains are joined in the gel-type vehicle of step 1, adding distil water stirs to 1000g, places and makes abundant swelling in 24 hours, stirs, and makes evenly, makes 1000g, can be sub-packed in 250 medicinal aluminum pipes, and every 4g, promptly.
Embodiment 2
Per 1000 gram compound zedoary turmeric oil gelata preparations take by weighing material by following prescription:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
CMC-Na 30g
Propylene glycol 25g
Ethanol 50g
Tween-80 50g
Sorbic acid 1g
Sodium pyrosulfite 1g
Vitamin E 0.5g
Deionized water adds to full dose
The raw material that takes by weighing is prepared compound zedoary turmeric oil gelata of the present invention according to the following steps:
1, get CMC-Na, moistening with propylene glycol, add an amount of distilled water, make abundant swelling, stir, get water white transparency sodium carboxymethyl cellulose substrate;
2, get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirs, and makes it to be emulsified into milky O/W type emulsion;
3, get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, the sodium pyrosulfite water dissolution;
4, the econazole nitrate porphyrize is crossed 80 mesh sieves;
5, respectively 2,3,4 step gains are joined in the above-mentioned CMC-Na substrate, add an amount of distilled water, stir, place and made abundant swelling in 24 hours, stir, make evenly, make 1000g, can be sub-packed in 250 medicinal aluminum pipes to 1000g, every 4g, promptly.
Embodiment 3
Per 1000 gram compound zedoary turmeric oil gelata preparations take by weighing material by following prescription:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Sodium alginate 20g
Propylene glycol 25g
Ethanol 50g
Tween-80 20g
Sorbic acid 1.5g
Sodium pyrosulfite 1.5g
Vitamin E 0.5g
Deionized water adds to full dose
The raw material that takes by weighing is prepared compound zedoary turmeric oil gelata of the present invention according to the following steps:
1, get sodium alginate, moistening with propylene glycol, add suitable quantity of water, make abundant swelling, stir, get water white transparency sodium alginate substrate;
2, get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirs, and makes it to be emulsified into milky O/W type emulsion;
3, get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, the sodium pyrosulfite water dissolution;
4, the econazole nitrate porphyrize is crossed 80 mesh sieves;
5, respectively 2,3,4 step gains are joined in the above-mentioned CMC-Na substrate, add an amount of distilled water, stir, place and made abundant swelling in 24 hours, stir, make evenly, make 1000g, can be sub-packed in 250 medicinal aluminum pipes to 1000g, every 4g, promptly.
Embodiment 4
Per 1000 gram compound zedoary turmeric oil gelata preparations take by weighing material by following prescription:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Carbopol 2g
CMC-Na 10g
Sodium hydroxide 2g
Propylene glycol 25g
Ethanol 50g
Tween-80 50g
Sorbic acid 3g
Sodium pyrosulfite 0.5g
Vitamin E 0.5g
Deionized water adds to full dose
The raw material that takes by weighing is prepared compound zedoary turmeric oil gelata of the present invention according to the following steps:
1, card taking POP, CMC-Na, moistening with propylene glycol, add suitable quantity of water, make abundant swelling, add sodium hydroxide with an amount of dissolved in distilled water, stir, get water white transparency substrate;
2, get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirs, and makes it to be emulsified into milky O/W type emulsion;
3, get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, the sodium pyrosulfite water dissolution;
4, the econazole nitrate porphyrize is crossed 80 mesh sieves;
5, respectively 2,3,4 step gains are joined in the above-mentioned CMC-Na substrate, add an amount of distilled water, stir, place and made abundant swelling in 24 hours, stir, make evenly, make 1000g, can be sub-packed in 250 medicinal aluminum pipes to 1000g, every 4g, promptly.
Claims (9)
1, a kind of compound zedoary turmeric oil gelata is characterized in that ingredient comprises in the preparation of 1000g:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Gel-type vehicle 1～30g.
2, compound zedoary turmeric oil gelata according to claim 1 is characterized in that described gel-type vehicle is one or more the mixed gel substrate in carbopol, sodium carboxymethyl cellulose, the sodium alginate.
3, compound zedoary turmeric oil gelata according to claim 1 is characterized in that also comprising in the composition sodium hydroxide, propylene glycol, ethanol, Tween-80, sorbic acid, sodium pyrosulfite, vitamin E and deionized water.
4, compound zedoary turmeric oil gelata according to claim 3 is characterized in that in the preparation of 1000g, the composition proportion scope is:
Econazole nitrate 12.5g
Oleum Curcumae 52.5ml
Gel-type vehicle 1～30g
Sodium hydroxide 1～4g
Propylene glycol 10～25g
Ethanol 20～100g
Tween-80 10～50g
Sorbic acid 1～4g
Sodium pyrosulfite 0.5～2g
Vitamin E 0.5-2g
Deionized water adds to full dose
5, compound zedoary turmeric oil gelata according to claim 4 is characterized in that gel-type vehicle is a carbopol, and its consumption is 1～20g.
6, compound zedoary turmeric oil gelata according to claim 4 is characterized in that gel-type vehicle is a sodium carboxymethyl cellulose, its consumption 10～30g.
7, compound zedoary turmeric oil gelata according to claim 4 is characterized in that gel-type vehicle is a sodium alginate, and its consumption is 10～30g.
8, compound zedoary turmeric oil gelata according to claim 4 is characterized in that gel-type vehicle is the mixed gel substrate of carbopol and sodium carboxymethyl cellulose, and its consumption is carbopol 1～5g, sodium carboxymethyl cellulose 5～10g.
9, a kind of preparation method of compound zedoary turmeric oil gelata may further comprise the steps:
(1), get the gel-type vehicle of proportional quantity, moistening with propylene glycol, adding distil water makes abundant swelling, or adds the sodium hydroxide with an amount of dissolved in distilled water, stirs, must colorless transparent gel substrate;
(2), get the Oleum Curcumae of proportional quantity, add ethanol, mixing joins in the Tween-80 solution with an amount of dissolved in distilled water again, stirring makes it to be emulsified into milky O/W type emulsion;
(3), get sorbic acid, the vitamin E dissolve with ethanol of proportional quantity, sodium pyrosulfite water dissolution;
(4), the econazole nitrate porphyrize of proportional quantity is crossed 80 mesh sieves;
(5), respectively 2,3,4 step gains are joined in the gel-type vehicle of step 1, add an amount of distilled water, stir to 1000g;
(6), place and to make abundant swelling in 10-36 hour, stir, packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031138 CN1803185A (en) | 2005-01-12 | 2005-01-12 | Compound zedoary turmeric oil gelata and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510031138 CN1803185A (en) | 2005-01-12 | 2005-01-12 | Compound zedoary turmeric oil gelata and its preparing method |
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| CN1803185A true CN1803185A (en) | 2006-07-19 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2445818A (en) * | 2006-09-15 | 2008-07-23 | Japan Atomic Energy Agency | Preparation of gels derived from carboxymethyl cellulose alkali metal salt |
| CN101157760B (en) * | 2006-09-15 | 2012-03-21 | 独立行政法人日本原子力研究开发机构 | Preparation of gels derived from carboxymethyl cellulose alkali metal salt |
| CN102824598A (en) * | 2012-06-18 | 2012-12-19 | 韩昌志 | Compound Rhizoma Curcumae oil effervescent ointment, and preparation method and use method thereof |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN109453439A (en) * | 2019-01-22 | 2019-03-12 | 郑州乐迪生物科技有限公司 | A kind of mucosa protective agent and preparation method thereof for domestic animal artificial insemination |
-
2005
- 2005-01-12 CN CN 200510031138 patent/CN1803185A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2445818A (en) * | 2006-09-15 | 2008-07-23 | Japan Atomic Energy Agency | Preparation of gels derived from carboxymethyl cellulose alkali metal salt |
| GB2445818B (en) * | 2006-09-15 | 2011-03-09 | Japan Atomic Energy Agency | Preparation of gels derived from carboxymethyl cellulose alkali metal salt |
| CN101157760B (en) * | 2006-09-15 | 2012-03-21 | 独立行政法人日本原子力研究开发机构 | Preparation of gels derived from carboxymethyl cellulose alkali metal salt |
| CN102824598A (en) * | 2012-06-18 | 2012-12-19 | 韩昌志 | Compound Rhizoma Curcumae oil effervescent ointment, and preparation method and use method thereof |
| CN104224923A (en) * | 2014-07-07 | 2014-12-24 | 海南华拓天涯制药有限公司 | Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology |
| CN109453439A (en) * | 2019-01-22 | 2019-03-12 | 郑州乐迪生物科技有限公司 | A kind of mucosa protective agent and preparation method thereof for domestic animal artificial insemination |
| CN109453439B (en) * | 2019-01-22 | 2021-05-14 | 郑州乐迪生物科技有限公司 | Mucous membrane protective agent for artificial insemination of livestock and preparation method thereof |
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