CN1748758A - Dragon's blood gel preparation and its preparing method - Google Patents
Dragon's blood gel preparation and its preparing method Download PDFInfo
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- CN1748758A CN1748758A CNA2005101091988A CN200510109198A CN1748758A CN 1748758 A CN1748758 A CN 1748758A CN A2005101091988 A CNA2005101091988 A CN A2005101091988A CN 200510109198 A CN200510109198 A CN 200510109198A CN 1748758 A CN1748758 A CN 1748758A
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Abstract
The present invention relates to a kind of dragon's blood gel preparation comprising dragon's blood in effective dosage as main medicine and gel mixed together. The preparation process includes dispersing polymer material as gel matrix inside solvent for full swelling, adding pH regulator to reasonable range, and adding preservative and permeation promoter to form gel; adding fine dragon's blood powder and mixing homogeneously. The dragon's blood gel preparation may be used in treating traumatic injury, bedsore, epidermis ulcer, chronic cervicitis and other diseases. The dragon's blood gel preparation has excellent skin adhesion, excellent spreading property, high permeation and high transdermal absorption effect.
Description
Technical field:
The invention belongs to field of medicaments, relate to a kind of by Sanguis Draxonis as external-use gel preparation of active constituents of medicine and preparation method thereof.Dragon's blood gel preparation of the present invention can be used for treating diseases such as traumatic injury, decubital ulcer, epidermis ulcer, chronic cervicitis, oral ulcer.
Background technology:
Sanguis Draxonis has another name called Sanguis Draxonis, and as the history in existing more than 1500 year of rare Chinese medicine, the Fructus Crotonis that derives from the dracaena of Agavaceae, palmaceous Daemonorops, Euphorbiaceae belongs to, pulse family amboyna platymiscium in China.Sanguis Draxonis has the effect of timid silt analgesic therapy, hemostasia and promoting granulation, is used to fall pounce on and loses, and internal injury is become silted up bitterly, continuous bleeding due to traumatic injury.Generally grind or go into behind the ball for oral administrationly, or grind and spread or go into the plaster external.
The agent of Sanguis Draxonis list, compound recipe be existing the application in fields such as surgery, gynecological, the department of stomatology, dermatological departments, as treatment traumatic injury, decubital ulcer, epidermis ulcer, chronic cervicitis, oral ulcer, condyloma acuminatum etc., adopts topical administration than oral administration better effects if often.
Regrettably, so far still do not have can external the Resina Draconis preparation as one listing, have only for oral Sanguis Draxonis loose, Sanguis Draxonis sheet, the buccal tablet of capsule and buccal, time spent can only be with oral powder (as Li Wei etc. outside, XUEJIE SAN treatment acute soft tissue injury 60 examples, Inner Mongol Chinese medicine, 1997 supplementary issues, 13-14.) or get capsule 's content (Ma Xiuying, Liang Kaiyun, the observation of curative effect of dragon's blood capsule treatment varicose ulcer of lower extremity, laser magazine,, the 25th the 1st phase of volume, 45 in 2004.), or the Sanguis Draxonis crude drug is beaten powder, and (Yang Huiying etc., XUEJIE SAN is treated the observation of curative effect and the Experience of Nursing of decubital ulcer, Harbin medicine,, the 22nd volume the 4th phase: 95-96 in 2002.) use, existing and use inconvenience, dosage is inaccurate, shortcomings such as drug waste, the quality of especially making preparation by oneself more makes people worried.The present invention is intended to solve the above problem that exists under the prior art.
Summary of the invention:
This provides a kind of easy to use, dosage dragon's blood gel preparation and preparation method thereof accurately, treat diseases such as traumatic injury, decubital ulcer, epidermis ulcer, chronic cervicitis, oral ulcer under the prior art and do not have suitable external preparation to solve, and dosage is inaccurate and difficulty such as drug waste.The gel that uses preparation method of the present invention to make has good skin adhesion, stretchability, permeability, and Transdermal absorption is effective, use science, convenience, comfortable no sand type.
Dragon's blood gel preparation provided by the invention, as active component, suitable blank gel is mixed with and forms with making gel preparation by the Sanguis Draxonis of effective dose.
The Fructus Crotonis that described Sanguis Draxonis can derive from the dracaena of Agavaceae, palmaceous Daemonorops, Euphorbiaceae belongs to, pulse family amboyna platymiscium.
Dragon's blood gel preparation provided by the invention, wherein the percentage by weight of Sanguis Draxonis is 10～50%, and the percentage by weight of adjuvant is 50～90%, and Sanguis Draxonis concentration is preferably 10～40% (w/w).
Dragon's blood gel preparation provided by the invention, adjuvant is selected from substrate, penetration enhancer, antiseptic, pH regulator agent, solvent, the percentage by weight of its mesostroma is 0.05～10%, the percentage by weight 0～30% of penetration enhancer, the percentage by weight of antiseptic is 0.005～1%, and the percentage by weight of solvent is 8～88%.
Dragon's blood gel preparation provided by the invention, gel-type vehicle can be selected from: any in water, glycerol, propylene glycol, PEG400, cellulose derivative, carbomer and alginate, tragacanth, pectin, gelatin, xanthan gum, agar, chitin, ethene polymers, acrylic resin, polyvinyl alcohol and the carbopol or several;
Antiseptic be selected from methyl hydroxybenzoate, ethyl hydroxybenzoate, sodium benzoate and the thimerosal any or several, be preferably the mixture of methyl hydroxybenzoate, ethyl hydroxybenzoate;
Penetration enhancer be selected from propylene glycol, isopropyl alcohol, dimethyl sulfoxide, azone and, in the Borneolum Syntheticum any or several, be preferably propylene glycol or/and azone;
The pH regulator agent is selected from sodium hydroxide, triethanolamine or other alkaline solutions, is preferably triethanolamine, sodium hydroxide.
Solvent be selected from water, ethanol, the propylene glycol any or several, preferred water.
The preparation method of dragon's blood gel preparation of the present invention is characterised in that: be scattered in the solvent gel-type vehicle macromolecular material and abundant swelling, add the pH regulator agent in case of necessity, regulate pH to zone of reasonableness, obtain adding behind the homogeneous macromolecular solution other and be prepared into blank gel after as antiseptic, penetration enhancer, add Sanguis Draxonis powder (crossing 100 mesh sieves at least) again, make behind the mixing through micronizing.
The preferred preparation prescription of the present invention is:
Prescription 1 (to make the 1000g gel):
Sanguis Draxonis 200g
Hydroxypropyl methylcellulose (4000Mpa.s) 8g
Acritamer 940 2.4g
Propylene glycol 167g
Methyl hydroxybenzoate 0.15g
Sodium hydroxide is an amount of
Water for injection adds to 1000g
Prescription 2 (to make the 1000g gel):
Sanguis Draxonis 200g
Cross-linked sodium polyacrylate 400 10g
Glycerol 50g
Methyl hydroxybenzoate 0.15g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
Prescription 3 (to make the 1000g gel):
Sanguis Draxonis 200g
Propylene glycol 20g
Laurocapram 20g
Triethanolamine 10g
Thimerosal 0.1g
Carbomer 10g
Water for injection adds to 1000g
Prescription 4 (to make the 1000g gel):
Sanguis Draxonis 400g
CMC-Na 20g
Glycerol 100g
PEG400 50g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
Prescription 5 (to make the 1000g gel):
Sanguis Draxonis 200g
PVA0488 45g
PVP 45g
Glycerol 75g
Propylene glycol 30g
Ethyl hydroxybenzoate 0.1g
Water for injection adds to 1000g
The present invention also provides the preparation method of pharmaceutical preparation of the present invention, comprises that hand lapping, mechanical agitation and breast are even etc., and preparation equipment can be selected agitator, dispersing emulsification machine etc. for use.Can operate according to galenic pharmacy routine techniques method.
Below in order to beneficial effect of the present invention to be described:
Modern pharmacology studies confirm that Sanguis Draxonis has the coronary flow of increasing and improves the unusual effect of hemorheology, suppresses uterine smooth muscle and shrinks, anti-inflammatory analgetic, blood viscosity lowering, platelet aggregation degree, inhibition thrombosis, effects such as hemostasis.To be used for the treatment of hematuria after cerebral infarction, coronary heart disease, upper gastrointestinal hemorrhage, gynecologic blood diseases and inflammation, traumatic injury, hemorrhoid, decubital ulcer, vasculitis, type ii diabetes, peripheral circulation disorders and the kidney surgery etc.
Acute toxicity test records mouse stomach LD
50It is 153.75～366g/Kg body weight, chronic toxicity test shows, divide 3g/Kg for the rabbit gastric infusion, 1.5g/Kg, every day 1 time, continuous 90 days, quantity to RBC, WBC in the blood, gpt activity, urea nitrogen content and body weight gain etc. all do not have obviously influence, to all harmless effects such as liver, lung, kidney, intestinal, adrenal gland.Acute and chronic toxicological experiment result shows that Sanguis Draxonis is a kind of safe, the medicine that has no adverse reaction.With warm water or wine 2～3g for oral administration, external Chinese liquor is transferred and is applied the affected part, all proves safe and reliable clinically.With the people of 50kg body weight, oral 625g just can cause toxic reaction, the effective dose 2～3g of this and it compares, and safety coefficient is very high, we can say nontoxicly substantially, can not cause any untoward reaction.It is reported the anaphylaxis about 1/10000 is only arranged, but disappear after the drug withdrawal, do not need to obey any antiallergic agent.
The dragon's blood gel preparation of the present invention's preparation is because the technology advanced person, can not only guarantee the clinical efficacy of Sanguis Draxonis under the prior art, and its curative effect of higher lifting, and high made things convenient for clinical practice, improved the accuracy of using dosage greatly, it is more reasonable to make the application of this precious medicine resource of Sanguis Draxonis.The gel that uses preparation method of the present invention to make has good skin adhesion, stretchability, permeability, and Transdermal absorption is effective, use science, convenience, comfortable no sand type.
Below but be not limited only to superiority and the curative effect of following data in order to this gel preparation to be described
1, preparation superiority
Divide the dragon's blood gel get the inventive method preparation and WAISHANG RUYI GAO (Foshan Fengliaoxing Pharmaceutical Co., Ltd.'s production) 30g to pack in the ointment box, be divided into three groups, every group 5 box, put into calorstat (39 ℃) respectively, (4 ℃) are observed in room temperature (25 ℃) and the refrigerator, behind the 45d, with the uniformity of sample, to smear ductility, wettability, layering etc. be evaluation index, compare.The results are shown in Table 1.
The character of table 1 Sanguis Draxonis exterior-applied gel of the present invention and WAISHANG RUYI GAO relatively
| Group | Uniformity | Smear ductility | Wettability | Layering | ||||||||
| 39℃ | 25℃ | 4℃ | 39℃ | 25℃ | 4℃ | 39℃ | 25℃ | 4℃ | 39℃ | 25℃ | 4℃ | |
| Matched group | Well | Well | Well | Generally | Generally | Generally | Do not have | Do not have | Do not have | A little | A little | Do not have |
| Sample sets | Well | Well | Well | Good | Good | Good | Good | Good | Good | Do not have | Do not have | Do not have |
2, curative effect
To traumatic injury wound, fracture-dislocation, the injury of tendon and muscle long-pendingly become silted up, the skin and flesh damage is suppurated etc. belongs to case and adopt random packet to carry out clinical efficacy relatively, the treatment group adopts the dragon's blood gel agent cream of the inventive method preparation, matched group adopts WAISHANG RUYI GAO, result such as table 2.
The clinical efficacy of table 2 dragon's blood gel and WAISHANG RUYI GAO relatively
| Group | Recovery from illness | Produce effects | Effectively | Invalid | Add up to | Effective percentage |
| The treatment group | 42 people | 4 people | 3 people | 1 people | 50 people | 98％ |
| Matched group | 37 people | 5 people | 2 people | 6 people | 50 people | 88％ |
The result shows that dragon's blood gel agent of the present invention has better therapeutic (P＜0.01) with respect to the WAISHANG RUYI GAO of prior art.
By above table 1,2 results as can be seen, on function and curative effect, especially aspect the preparation superiority, the dragon's blood gel of the inventive method preparation obviously is better than WAISHANG RUYI GAO, thereby improved compliance and the compliance that the stability of said preparation and patient use to a great extent, also easilier accepted by all kinds of patients.
The specific embodiment:
Further specify the present invention by the following examples.But the scope of the inventive method is not limited to following example.
Example 1:
Prescription:
Sanguis Draxonis 200g
Hydroxypropyl methylcellulose (4000Mpa.s) 8g
Acritamer 940 2.4g
Propylene glycol 167g
Methyl hydroxybenzoate 0.15g
Sodium hydroxide is an amount of
Water for injection adds to 1000g
Preparation method:
The first step: Sanguis Draxonis is carried out micronizing get micropowders, standby;
Second step: in addition hydroxypropyl methylcellulose (4000Mpa.s) is scattered in 80～90 ℃ of hot water, put the refrigerator overnight cooling and make it into clear and bright solution, in addition Acritamer 940 is scattered in the 200ml water, adding q.s 1% sodium hydroxide solution, to be transferred to pH be 7, add Purified Water to about 400ml, methyl hydroxybenzoate is dissolved in the propylene glycol the above-mentioned solution mix homogeneously white gel substrate of promptly having leisure.
The 3rd step: above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Example 2:
Prescription:
Sanguis Draxonis 200g
Cross-linked sodium polyacrylate 400 10g
Glycerol 50g
Methyl hydroxybenzoate 0.15g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
Preparation method:
The first step: Sanguis Draxonis is carried out micronizing get micropowders, standby;
Second step: get about 70%60 ℃ distilled water, cross-linked sodium polyacrylate 400 is spread on liquid level, place 24h and allow its swelling form gel, other gets methyl hydroxybenzoate, ethyl hydroxybenzoate glycerol adding in mortar and grinds well; Above-mentioned gel is added gradually, add water to about 800g, mixing promptly.
The 3rd step: above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Example 3:
Prescription:
Sanguis Draxonis 200g
Propylene glycol 20g
Laurocapram 20g
Triethanolamine 10g
Thimerosal 0.1g
Carbomer 10g
Water for injection adds to 1000g
Preparation method:
The first step: Sanguis Draxonis is carried out micronizing get micropowders, standby;
Second step: get Acritamer 940 and be scattered in an amount of hot distilled water, place the 24h self swelling, transfer pH6.5～7.5 with triethanolamine, the distilled water that takes a morsel dissolves thimerosal, gets propylene glycol, laurocapram, respectively above-mentioned composition is added in the gel-type vehicle, distilled water adds to full dose, and mixing promptly.
The 3rd step: above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Example 4:
Prescription:
Sanguis Draxonis 400g
CMC-Na 20g
Glycerol 100g
PEG400 50g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
The first step: Sanguis Draxonis is carried out micronizing get micropowders, standby;
Second step: get about 70% distilled water, CMC-Na is spread on liquid level, place 24h and allow its swelling form gel, other gets methyl hydroxybenzoate, ethyl hydroxybenzoate and grinds well among glycerol adding and the PEG400 in mortar, with above-mentioned mixing of materials, adds water to about 600g, and mixing promptly.
The 3rd step: above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Example 5:
Prescription:
Sanguis Draxonis 200g
PVA0488 45g
PVP 45g
Glycerol 75g
Propylene glycol 30g
Ethyl hydroxybenzoate 0.1g
Water for injection adds to 1000g
The first step: Sanguis Draxonis is carried out micronizing get micropowders, standby;
Second step: get about 70%80-90 ℃ distilled water, PVA0488 add is stirred,, place 24h and allow its swelling form gel, get PVP, add the suitable quantity of water dissolving, other taking ethylparaben grinds well in glycerol adding and the propylene glycol in mortar; Above-mentioned gel is added gradually, add water to 800g, mixing promptly.
The 3rd step: above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Claims (10)
1 one kinds of dragon's blood gel preparations is characterized in that,, are mixed with suitable blank gel and form as active constituents of medicine by the Sanguis Draxonis of effective dose.The Fructus Crotonis that described Sanguis Draxonis derives from the dracaena of Agavaceae, palmaceous Daemonorops, Euphorbiaceae belongs to, pulse family amboyna platymiscium.
The described dragon's blood gel preparation of 2 claim 1 is characterized in that, wherein the percentage by weight of Sanguis Draxonis is 10～50%, and the percentage by weight of adjuvant is 50～90%, and Sanguis Draxonis concentration is preferably 10～40% (w/w).
The dragon's blood gel preparation of 3 claim 2, it is characterized in that, wherein said adjuvant comprises substrate, penetration enhancer, antiseptic, pH regulator agent, solvent, the percentage by weight of its mesostroma is 0.05～10%, the percentage by weight 0～30% of penetration enhancer, the percentage by weight of antiseptic is 0.005～1%, and the percentage by weight of solvent is 8～88%.
The dragon's blood gel preparation of 4 claim 2, it is characterized in that, substrate is aqueous gel substrate, can be selected from: any in water, glycerol, propylene glycol, PEG400, cellulose derivative, carbomer and alginate, tragacanth, pectin, gelatin, xanthan gum, agar, chitin, ethene polymers, acrylic resin, polyvinyl alcohol and the carbopol or several; Antiseptic be selected from methyl hydroxybenzoate, ethyl hydroxybenzoate, sodium benzoate and the thimerosal any or several, be preferably the mixture of methyl hydroxybenzoate, ethyl hydroxybenzoate; Penetration enhancer be selected from propylene glycol, isopropyl alcohol, dimethyl sulfoxide, azone and, in the Borneolum Syntheticum any or several, be preferably propylene glycol or/and azone; The pH regulator agent is selected from sodium hydroxide, triethanolamine or other alkaline solutions, is preferably triethanolamine, sodium hydroxide.Solvent be selected from water, ethanol, the propylene glycol any or several, preferred water.
The preparation method of the described dragon's blood gel preparation of 5 claim 1～4, it is characterized in that, be scattered in the solvent gel-type vehicle macromolecular material and abundant swelling, add the pH regulator agent in case of necessity, regulate pH to zone of reasonableness, obtain adding behind the homogeneous macromolecular solution other and be prepared into blank gel after as antiseptic, penetration enhancer, add Sanguis Draxonis powder (crossing 100 mesh sieves at least) again, make behind the mixing through micronizing.
The external dragon's blood gel of 6 claim 2～5 is characterized in that, whenever to make 1000g, its prescription consists of:
Sanguis Draxonis 200g
Hydroxypropyl methylcellulose (4000Mpa.s) 8g
Acritamer 940 2.4g
Propylene glycol 167g
Methyl hydroxybenzoate 0.15g
Sodium hydroxide is an amount of
Water for injection adds to 1000g
Its preparation method and step are: Sanguis Draxonis is carried out micronizing get micropowders, it is standby to cross 100 mesh sieves; In addition hydroxypropyl methylcellulose (4000Mpa.s) is scattered in 80～90 ℃ of hot water, put the refrigerator overnight cooling and make it into clear and bright solution, in addition Acritamer 940 is scattered in the 200ml water, adding q.s 1% sodium hydroxide solution, to be transferred to pH be 7, add Purified Water to about 400ml, methyl hydroxybenzoate is dissolved in the propylene glycol the above-mentioned solution mix homogeneously white gel substrate of promptly having leisure; Above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
The external dragon's blood gel of 7 claim 2～5 is characterized in that, whenever to make 1000g, its prescription consists of:
Sanguis Draxonis 200g
Cross-linked sodium polyacrylate 400 10g
Glycerol 50g
Methyl hydroxybenzoate 0.15g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
Its preparation method and step are: Sanguis Draxonis is carried out micronizing get micropowders, it is standby to cross 100 mesh sieves; Get about 70%60 ℃ distilled water, cross-linked sodium polyacrylate 400 is spread on liquid level, place 24h and allow its swelling form gel, other gets methyl hydroxybenzoate, ethyl hydroxybenzoate glycerol adding in mortar and grinds well; Above-mentioned gel is added gradually, add water to about 800g, mixing promptly; Above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
The external dragon's blood gel of 8 claim 2～5 is characterized in that, whenever to make 1000g, its prescription consists of:
Sanguis Draxonis 200g
Propylene glycol 20g
Laurocapram 20g
Triethanolamine 10g
Thimerosal 0.1g
Carbomer 10g
Water for injection adds to 1000g
Its preparation method and step are: Sanguis Draxonis is carried out micronizing get micropowders, it is standby to cross 100 mesh sieves; Get Acritamer 940 and be scattered in an amount of hot distilled water, place the 24h self swelling, transfer pH6.5～7.5 with triethanolamine, the distilled water that takes a morsel dissolves thimerosal, gets propylene glycol, laurocapram, respectively above-mentioned composition is added in the gel-type vehicle, distilled water adds to full dose, and mixing promptly; Above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
The external dragon's blood gel of 9 claim 2～5 is characterized in that, whenever to make 1000g, its prescription consists of:
Sanguis Draxonis 400g
CMC-Na 20g
Glycerol 100g
PEG400 50g
Ethyl hydroxybenzoate 0.15g
Water for injection adds to 1000g
Its preparation method and step are: Sanguis Draxonis is carried out micronizing get micropowders, it is standby to cross 100 mesh sieves; Get about 70% distilled water, CMC-Na is spread on liquid level, place 24h and allow its swelling form gel, other gets methyl hydroxybenzoate, ethyl hydroxybenzoate and grinds well among glycerol adding and the PEG400 in mortar, with above-mentioned mixing of materials, adds water to about 600g, and mixing promptly; Above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
The external dragon's blood gel of 10 claim 2～5 is characterized in that, whenever to make 1000g, its prescription consists of:
Sanguis Draxonis 200g
PVA0488 45g
PVP 45g
Glycerol 75g
Propylene glycol 30g
Ethyl hydroxybenzoate 0.1g
Water for injection adds to 1000g
Its preparation method and step are: Sanguis Draxonis is carried out micronizing get micropowders, it is standby to cross 100 mesh sieves; Get about 70%80-90 ℃ distilled water, PVA0488 add stirred,, place 24h and allow its swelling form gel, get PVP, add the suitable quantity of water dissolving, taking ethylparaben grinds well in glycerol adding and the propylene glycol in mortar in addition; Above-mentioned gel is added gradually, add water to 800g, mixing promptly; Above Sanguis Draxonis micropowders is slow, and gradation is added in the above blank substrate, and the limit edged stirs, until evenly, and 100 ℃ of flowing steam sterilization 30min, packing is promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101091988A CN1748758A (en) | 2005-10-20 | 2005-10-20 | Dragon's blood gel preparation and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101091988A CN1748758A (en) | 2005-10-20 | 2005-10-20 | Dragon's blood gel preparation and its preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2942134A1 (en) * | 2009-02-13 | 2010-08-20 | Millet Innovation | MATERIAL FOR THE PREVENTION OF THE ESCARRES |
| CN104825532A (en) * | 2015-04-14 | 2015-08-12 | 山东金诃药物研究开发有限公司 | Oxytropis chiliophylla royle itching eliminating gel and preparation method thereof |
| CN112915257A (en) * | 2021-04-25 | 2021-06-08 | 山东采采医疗科技有限公司 | Preparation method of sterilized cellulose gel |
| CN115531480A (en) * | 2022-10-20 | 2022-12-30 | 重庆伊士腾生物科技有限公司 | Gel preparation for treating diabetic skin ulcer and preparation method thereof |
-
2005
- 2005-10-20 CN CNA2005101091988A patent/CN1748758A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2942134A1 (en) * | 2009-02-13 | 2010-08-20 | Millet Innovation | MATERIAL FOR THE PREVENTION OF THE ESCARRES |
| WO2010092259A3 (en) * | 2009-02-13 | 2010-11-18 | Millet Innovation | Material for the prevention of bedsores |
| US8716383B2 (en) | 2009-02-13 | 2014-05-06 | Millet Innovation | Material for the prevention of bedsores |
| CN104825532A (en) * | 2015-04-14 | 2015-08-12 | 山东金诃药物研究开发有限公司 | Oxytropis chiliophylla royle itching eliminating gel and preparation method thereof |
| CN104825532B (en) * | 2015-04-14 | 2019-09-24 | 金诃藏药（山东）健康产业有限公司 | A kind of whin disappears gel and preparation method thereof of itching |
| CN112915257A (en) * | 2021-04-25 | 2021-06-08 | 山东采采医疗科技有限公司 | Preparation method of sterilized cellulose gel |
| CN112915257B (en) * | 2021-04-25 | 2022-06-24 | 山东采采医疗科技有限公司 | Preparation method of sterilized cellulose gel |
| CN115531480A (en) * | 2022-10-20 | 2022-12-30 | 重庆伊士腾生物科技有限公司 | Gel preparation for treating diabetic skin ulcer and preparation method thereof |
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