CN1947701A - Solid self-micro emulsion contg. jervic alcohol for antineoplastic medicine and its prepn. method - Google Patents
Solid self-micro emulsion contg. jervic alcohol for antineoplastic medicine and its prepn. method Download PDFInfo
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- CN1947701A CN1947701A CN 200610070024 CN200610070024A CN1947701A CN 1947701 A CN1947701 A CN 1947701A CN 200610070024 CN200610070024 CN 200610070024 CN 200610070024 A CN200610070024 A CN 200610070024A CN 1947701 A CN1947701 A CN 1947701A
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Abstract
An antineoplastic self-microemulsifying solid of resveratrol with high stability and solubility in gastonintesinal tract is prepared through preparing the concentrated liquid of self-microemulsifying composition proportionally from resveratrol, emulsifier, emulsifying aid, and oil, adding the mixture of mannitol and calcium lactate, stirring or ultrasonic dissolving, and freeze-drying.
Description
Technical field
The present invention relates to a kind of anti-tumor drug, specifically, relate to a kind of jervic alcohol for antineoplastic medicine solid self-microemulsion agent and preparation method thereof.
Background technology
Tumor is a kind of commonly encountered diseases and frequently-occurring disease, and is very big to the people's life and health threat, is the research topic that more and more comes into one's own in medical domain.Every year is died from cancer person more than 7,000,000 in the whole world, now cancer patient about 37,000,000.In China, there are every year 1300000 people to die from tumor approximately, estimate sickness rate between 1,800,000～2,000,000, total sickness rate is in continuous rising.In a plurality of at home big cities, malignant tumor has surpassed cardiovascular and cerebrovascular disease, come first of all disease death reasons, and at 35～59 years old age bracket, tumor is first killer always.Because the deadly infectious disease of many serious threat people's life health is under control in the past, the average life span prolongs gradually, and diagnostic techniques improves constantly, but the carcinogenic factor in the human environment day by day increases, therefore in a lot of countries, it is the first or second that cancer occupies the cause of death at present.
Tumor treatment has operation, radiation and chemotherapy at present, to a great extent based on chemotherapy.Operation is relatively poor with the compliance of radiation therapy method, and chemotherapy can bring bigger toxic and side effects to the patient, when suppressing and poisoning the tumor cell of active proliferation, medullary cell, enterocyte, hair cell and sexual cell are produced inhibitory action too, lose therapeutical effect thereby be easy to generate drug resistance simultaneously.Along with improving constantly of The development in society and economy and living standards of the people, people are also improving constantly the requirement of life, quality of life, and the appearance of the antitumor drug of high-efficiency low-toxicity green environmental protection is also enjoyed popular confidence.
In international medicine development back to nature, traditional medicine excavation and application under the new situation, the Study on Modernization of Chinese medicine preparation has become the focus of field of medicaments research.Resveratrol is the stronger non-flavonoid polyphenolic substance of a kind of activity that exists in many plants.
Resveratrol has the prevention of cardiovascular disease and tumor and health-care effect are caused in the world paid close attention to widely and furtherd investigate, and extensively sells in American-European market as health product and food additive.In recent years, active and concrete mechanism is furtherd investigate in a large number to the resveratrol antineoplastic both at home and abroad, thinks at present one of most promising anticancer composition that can match in excellence or beauty with paclitaxel.Studies have shown that at present resveratrol not only has the cardiovascular disease of control, antiinflammation, and the more important thing is that it has anti-cancer, antitumaous effect widely.
Though resveratrol is a up-and-coming tumor prevention and a curative, because resveratrol is insoluble in water, and to photo-labile, the limitation of himself physicochemical properties, it is relatively poor to cause it to absorb in vivo, and bioavailability is not high, and clinical effectiveness is not satisfactory.
Summary of the invention
The purpose of this invention is to provide a kind of good stability, bioavailability height, can effectively prevent and treat jervic alcohol for antineoplastic medicine solid self-microemulsion agent of tumor disease and preparation method thereof.
For achieving the above object, technical scheme of the present invention is: the agent of jervic alcohol for antineoplastic medicine solid self-microemulsion, it is characterized in that: described Emulsion is made up of resveratrol and adjuvant.
Below be improvement of the technical scheme:
Described adjuvant comprises following component:
Oil phase, emulsifying agent, co-emulsifier.
Described oil phase is one or both of following composition:
Ethyl oleate, Ethyl linoleate, Oleum Ricini, isopropyl myristate, butyl oleate, sad or capric acid triacylglycerol, oleic acid or linoleic acid or linolenic acid triacylglycerol.
Described emulsifying agent is one or both of following composition:
Tween 80, polyoxyethylene hydrogenated Oleum Ricini, tween 85, polyoxyethylene castor oil, Polyethylene Glycol-the sad or decanoin of 8-glycerol.
Described co-emulsifier is one or both of following composition:
Ethanol, 1,2-propylene glycol, glycerol, PEG400, ethylene glycol monomethyl ether.
The percentage by weight of described each composition of Emulsion is:
Resveratrol 5～15%
Oil phase 15～70%
Emulsifying agent 10～60%
Co-emulsifier 5～25%.
The percentage by weight of described each composition of Emulsion is:
Resveratrol 8～12%
Oil phase 30～60%
Emulsifying agent 20～50%
Co-emulsifier 5～25%.
The percentage by weight of described each composition of Emulsion is:
Resveratrol 10%
Oil phase 45%
Emulsifying agent 30%
Co-emulsifier 15%.
The preparation method of jervic alcohol for antineoplastic medicine solid self-microemulsion agent may further comprise the steps:
A, proportionally precision takes by weighing resveratrol, emulsifying agent, co-emulsifier;
B, put into conical flask successively, in 37 ℃ of water-baths, heat with stopper, and mix homogeneously;
C, proportionally precision takes by weighing oil phase, puts into conical flask, and mixing promptly gets the concentrated solution of resveratrol self-emulsion composition, at room temperature keeps in Dark Place, and is standby;
D, according to 5: 1～10: 1 weight ratio mannitol, calcium lactate, mix the agent that is supported, precision takes by weighing the proppant of concentrated solution quality 5～15%, and proppant is mixed with the Emulsion concentrated solution of gained, adopts to stir or the promotion of ultransonic method is dissolved;
E, mensuration lowest total of the melting point: adopt electric-resistivity method to measure its lowest total of the melting point;
F, preparation lyophilizing breast: will measure the Emulsion of lowest total of the melting point, first pre-freeze is put into freezer dryer then and is prepared freeze-dried emulsion to following 10～20 ℃ of eutectic point, promptly obtains the Emulsion finished product.
The structural formula of resveratrol is:
Resveratrol, English name are Resveratrol or Res, chemistry is by name 3,4 ', 5-trihydroxy-anti--stilbene, molecular formula is C
14H
12O
3, molecular weight is 228.2.
Resveratrol is the non-flavonoid polyphenolic substance of a kind of activity that exists in many plants.The resveratrol acicular crystal that is white in color is insoluble in water, is insoluble to ether, can be dissolved in ethanol, ethyl acetate, the acetone equal solvent; Studies show that: resveratrol has antitumor, antioxidation, anti-cardiovascular disease, antibacterium, antiinflammatory, and anticoagulant is regulated effects such as immunity.
Resveratrol be plant under adverse circumstances or suffer pathogen when infringement, the excretory a kind of antitoxin of plant self can be resisted the infection of mycete.It is because of plant is subjected to fungal infection, produces under ultraviolet radiation or the pathological condition, and similar is in the estrogen diethylstilbestrol.
Resveratrol extensively is present in Vitaceae (Parthenocissus, Vitis Amurensis belong to), Liliaceae (Veratrum), Polygonaceae (Liao's genus, Rheum), pulse family (Sophora, Arachis, Trifolium, Bauhinia, Ilex), Umbelliferae (rib apium), the section that takes to the greenwood (tongue genus), Palmae (phoenix), the Gnetaceae various plants such as (Gnetums), also contains this material in 70 kind of plant such as Semen arachidis hypogaeae, Fructus Mori, Fructus Vitis viniferae.In plants such as the Chinese medicine Rhizoma Polygoni Cuspidati of China, Radix Polygoni Multiflori, also found the existence of resveratrol.
The most noticeable in every pharmacological action of resveratrol is antitumor action, but it is reported and the propagation of kinds of tumor cells in a plurality of systems such as the digestion of resveratrol antagonism, breathing, blood, reproduction source nasopharyngeal carcinoma, hepatocarcinoma, pulmonary carcinoma, gastric cancer, breast carcinoma, carcinoma of prostate, thyroid carcinoma, leukemia etc. are all had therapeutical effect.
Think that at present resveratrol mainly is by suppressing the cytochrome enzyme, inducing approach such as separating toxenzyme, inhibition Cycloxygenase, Profilin kinases, antagonism estrogen receptor, the differentiation of promotion tumor cell and apoptosis to reach antineoplastic action.
Beneficial effect:
The present invention adopts above technical scheme, and it is made the solid self-micro emulsion formulation, when having improved resveratrol bioavailability and medicine stability, has also widened the use crowd scope of medicine; After resveratrol made the solid self-microemulsion, not only improve stability of drug and indissoluble is separated, difficulty absorbs the drug in gastrointestinal tract bioavailability, and improved cancer patient's life quality, also reduced chemotherapy, radiocurable toxic and side effects.
The present invention's stability is high, bioavailability is high, can prevent and treat tumor disease, so have higher economic value and society generalization value.
Specific embodiment
Embodiment 1: the agent of jervic alcohol for antineoplastic medicine solid self-microemulsion, described Emulsion is made up of resveratrol and adjuvant.
Described adjuvant is made up of oil phase, emulsifying agent, co-emulsifier, proppant,
Described oil phase is made up of ethyl oleate, Ethyl linoleate,
Described emulsifying agent is made up of tween 80, polyoxyethylene hydrogenated Oleum Ricini,
Described co-emulsifier is: ethanol,
Described proppant is made up of mannitol, calcium lactate, and the weight ratio of mannitol, calcium lactate is 5: 1,
The percentage by weight of described each composition of Emulsion is:
Resveratrol 5%
Oil phase 70%
Emulsifying agent 15%
Co-emulsifier 10%.
The quality of resveratrol and oil phase, emulsifying agent, co-emulsifier and: proppant=100: 5
The preparation method of jervic alcohol for antineoplastic medicine solid self-microemulsion agent may further comprise the steps:
A, proportionally precision takes by weighing resveratrol, emulsifying agent, co-emulsifier;
B, put into conical flask successively, in 37 ℃ of water-baths, heat with stopper, and mix homogeneously;
C, proportionally precision takes by weighing oil phase, puts into conical flask, and mixing promptly gets the concentrated solution of resveratrol self-emulsion composition, at room temperature keeps in Dark Place, and is standby;
D, according to weight ratio mannitol, calcium lactate, mix the agent that is supported, precision takes by weighing the proppant of concentrated solution quality 5%, and proppant is mixed with the Emulsion concentrated solution of gained, adopts to stir or the promotion of ultransonic method is dissolved;
E, mensuration lowest total of the melting point: adopt electric-resistivity method to measure its lowest total of the melting point;
F, preparation lyophilizing breast: will measure the Emulsion of lowest total of the melting point, first pre-freeze is put into freezer dryer then and is prepared freeze-dried emulsion to following 10 ℃ of eutectic point, promptly obtains the Emulsion finished product.
Embodiment 2: the agent of jervic alcohol for antineoplastic medicine solid self-microemulsion, described Emulsion is made up of resveratrol and adjuvant.
Described adjuvant is made up of oil phase, emulsifying agent, co-emulsifier, proppant,
Described oil phase is made up of Oleum Ricini, isopropyl myristate,
Described emulsifying agent is made up of tween 85, polyoxyethylene castor oil,
Described co-emulsifier is: glycerol,
Described proppant is made up of mannitol, calcium lactate, and the weight ratio of mannitol, calcium lactate is 7.5: 1,
The percentage by weight of described each composition of Emulsion is:
Resveratrol 10%
Oil phase 45%
Emulsifying agent 30%
Co-emulsifier 15%.
The quality of resveratrol and oil phase, emulsifying agent, co-emulsifier and: proppant=100: 10
The preparation method of jervic alcohol for antineoplastic medicine solid self-microemulsion agent may further comprise the steps:
A, proportionally precision takes by weighing resveratrol, emulsifying agent, co-emulsifier;
B, put into conical flask successively, in 37 ℃ of water-baths, heat with stopper, and mix homogeneously;
C, proportionally precision takes by weighing oil phase, puts into conical flask, and mixing promptly gets the concentrated solution of resveratrol self-emulsion composition, at room temperature keeps in Dark Place, and is standby;
D, according to weight ratio mannitol, calcium lactate, mix the agent that is supported, precision takes by weighing the proppant of concentrated solution quality 10%, and proppant is mixed with the Emulsion concentrated solution of gained, adopts to stir or the promotion of ultransonic method is dissolved;
E, mensuration lowest total of the melting point: adopt electric-resistivity method to measure its lowest total of the melting point;
F, preparation lyophilizing breast: will measure the Emulsion of lowest total of the melting point, first pre-freeze is put into freezer dryer then and is prepared freeze-dried emulsion to following 15 ℃ of eutectic point, promptly obtains the Emulsion finished product.
Embodiment 3: the agent of jervic alcohol for antineoplastic medicine solid self-microemulsion, described Emulsion is made up of resveratrol and adjuvant.
Described adjuvant is made up of oil phase, emulsifying agent, co-emulsifier, proppant,
Described oil phase is by butyl oleate, the sad composition,
Described emulsifying agent is Polyethylene Glycol-sad or decanoin of 8-glycerol,
Described co-emulsifier is made up of PEG400, ethylene glycol monomethyl ether,
Described proppant is made up of mannitol, calcium lactate, and the weight ratio of mannitol, calcium lactate is 10: 1,
The percentage by weight of described each composition of Emulsion is:
Resveratrol 15%
Oil phase 20%
Emulsifying agent 45%
Co-emulsifier 20%.
The quality of resveratrol and oil phase, emulsifying agent, co-emulsifier and: proppant=100: 15
The preparation method of jervic alcohol for antineoplastic medicine solid self-microemulsion agent may further comprise the steps:
A, proportionally precision takes by weighing resveratrol, emulsifying agent, co-emulsifier;
B, put into conical flask successively, in 37 ℃ of water-baths, heat with stopper, and mix homogeneously;
C, proportionally precision takes by weighing oil phase, puts into conical flask, and mixing promptly gets the concentrated solution of resveratrol self-emulsion composition, at room temperature keeps in Dark Place, and is standby;
D, according to weight ratio mannitol, calcium lactate, mix the agent that is supported, precision takes by weighing the proppant of concentrated solution quality 15%, and proppant is mixed with the Emulsion concentrated solution of gained, adopts to stir or the promotion of ultransonic method is dissolved;
E, mensuration lowest total of the melting point: adopt electric-resistivity method to measure its lowest total of the melting point;
F, preparation lyophilizing breast: will measure the Emulsion of lowest total of the melting point, first pre-freeze is put into freezer dryer then and is prepared freeze-dried emulsion to following 20 ℃ of eutectic point, promptly obtains the Emulsion finished product.
Claims (9)
1, jervic alcohol for antineoplastic medicine solid self-microemulsion agent is characterized in that:
Described Emulsion is made up of resveratrol and adjuvant.
2, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 1 agent is characterized in that:
Described adjuvant comprises following component:
Oil phase
Emulsifying agent
Co-emulsifier.
3, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 2 agent is characterized in that:
Described oil phase is one or both of following composition:
Ethyl oleate
Ethyl linoleate
Oleum Ricini
Isopropyl myristate
Butyl oleate
Sad or capric acid triacylglycerol
Oleic acid or linoleic acid or linolenic acid triacylglycerol.
4, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 2 agent is characterized in that:
Described emulsifying agent is one or both of following composition:
Tween 80
Polyoxyethylene hydrogenated Oleum Ricini
Tween 85
Polyoxyethylene castor oil
Polyethylene Glycol-the sad or decanoin of 8-glycerol.
5, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 2 agent is characterized in that:
Described co-emulsifier is one or both of following composition:
Ethanol
1, the 2-propylene glycol
Glycerol
PEG400
Ethylene glycol monomethyl ether.
6, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 2 agent is characterized in that:
The percentage by weight of described each composition of Emulsion is:
Resveratrol 5～15%
Oil phase 15～70%
Emulsifying agent 10～60%
Co-emulsifier 5～25%.
7, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 6 agent is characterized in that:
The percentage by weight of described each composition of Emulsion is:
Resveratrol 8～12%
Oil phase 30～60%
Emulsifying agent 20～50%
Co-emulsifier 5～25%.
8, jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 7 agent is characterized in that:
The percentage by weight of described each composition of Emulsion is:
Resveratrol 10%
Oil phase 45%
Emulsifying agent 30%
Co-emulsifier 15%.
9, the preparation method of jervic alcohol for antineoplastic medicine solid self-microemulsion as claimed in claim 8 agent, it is characterized in that: described preparation method may further comprise the steps:
A, proportionally precision takes by weighing resveratrol, emulsifying agent, co-emulsifier;
B, put into conical flask successively, in 37 ℃ of water-baths, heat with stopper, and mix homogeneously;
C, proportionally precision takes by weighing oil phase, puts into conical flask, and mixing promptly gets the concentrated solution of resveratrol self-emulsion composition, at room temperature keeps in Dark Place, and is standby;
D, take by weighing mannitol, calcium lactate according to 5: 1～10: 1 weight ratios, mix the agent that is supported, precision takes by weighing the proppant of concentrated solution quality 5～15%, and proppant is mixed with the Emulsion concentrated solution of gained, adopts to stir or the promotion of ultransonic method is dissolved;
E, mensuration lowest total of the melting point: adopt electric-resistivity method to measure its lowest total of the melting point;
F, preparation lyophilizing breast: will measure the Emulsion of lowest total of the melting point, first pre-freeze is put into freezer dryer then and is prepared freeze-dried emulsion to following 10～20 ℃ of eutectic point, promptly obtains the Emulsion finished product.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200610070024XA CN100493497C (en) | 2006-11-03 | 2006-11-03 | Solid self-micro emulsion containing jervic alcohol for antineoplastic medicine and its preparation method |
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| CNB200610070024XA CN100493497C (en) | 2006-11-03 | 2006-11-03 | Solid self-micro emulsion containing jervic alcohol for antineoplastic medicine and its preparation method |
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| CN1947701A true CN1947701A (en) | 2007-04-18 |
| CN100493497C CN100493497C (en) | 2009-06-03 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106816A (en) * | 2010-12-16 | 2011-06-29 | 天津迈迪瑞康生物医药科技有限公司 | Resveratrol nanometer preparation and preparation method thereof |
| CN101317832B (en) * | 2007-06-06 | 2011-08-31 | 周亚伟 | Oral administration nano-drug administration system of resveratrol |
| WO2012017451A1 (en) * | 2010-08-03 | 2012-02-09 | Sanjeev Khandelwal | A bio-stabilized resveratrol formulation |
| CN103877065A (en) * | 2012-12-20 | 2014-06-25 | 中国科学院大连化学物理研究所 | Lipid carrier, indissolvable pharmaceutical composition and preparation method thereof |
| CN104173199A (en) * | 2014-08-28 | 2014-12-03 | 苏州纳康生物科技有限公司 | Resveratrol submicroemulsion, as well as preparation method and applications of resveratrol submicroemulsion |
| CN107496181A (en) * | 2017-10-20 | 2017-12-22 | 上海家化联合股份有限公司 | Solubilizing systems containing resveratrol |
| TWI670068B (en) * | 2017-04-21 | 2019-09-01 | 大江生醫股份有限公司 | Uses of peanut skin extract in increasing expression of pdprd gene |
| CN110839897A (en) * | 2019-11-22 | 2020-02-28 | 上海海洋大学 | Self-microemulsion using tremella polysaccharide as natural emulsifier and preparation method and application thereof |
-
2006
- 2006-11-03 CN CNB200610070024XA patent/CN100493497C/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101317832B (en) * | 2007-06-06 | 2011-08-31 | 周亚伟 | Oral administration nano-drug administration system of resveratrol |
| WO2012017451A1 (en) * | 2010-08-03 | 2012-02-09 | Sanjeev Khandelwal | A bio-stabilized resveratrol formulation |
| CN102106816A (en) * | 2010-12-16 | 2011-06-29 | 天津迈迪瑞康生物医药科技有限公司 | Resveratrol nanometer preparation and preparation method thereof |
| CN103877065A (en) * | 2012-12-20 | 2014-06-25 | 中国科学院大连化学物理研究所 | Lipid carrier, indissolvable pharmaceutical composition and preparation method thereof |
| CN104173199A (en) * | 2014-08-28 | 2014-12-03 | 苏州纳康生物科技有限公司 | Resveratrol submicroemulsion, as well as preparation method and applications of resveratrol submicroemulsion |
| CN104173199B (en) * | 2014-08-28 | 2017-12-01 | 苏州纳康生物科技有限公司 | The preparation method and its usage of resveratrol Submicron Emulsion, resveratrol Submicron Emulsion |
| TWI670068B (en) * | 2017-04-21 | 2019-09-01 | 大江生醫股份有限公司 | Uses of peanut skin extract in increasing expression of pdprd gene |
| CN107496181A (en) * | 2017-10-20 | 2017-12-22 | 上海家化联合股份有限公司 | Solubilizing systems containing resveratrol |
| CN110839897A (en) * | 2019-11-22 | 2020-02-28 | 上海海洋大学 | Self-microemulsion using tremella polysaccharide as natural emulsifier and preparation method and application thereof |
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