CN1788738A - Medicinal preparation containing volatile oil and preparing method thereof - Google Patents
Medicinal preparation containing volatile oil and preparing method thereof Download PDFInfo
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- CN1788738A CN1788738A CNA2004100814627A CN200410081462A CN1788738A CN 1788738 A CN1788738 A CN 1788738A CN A2004100814627 A CNA2004100814627 A CN A2004100814627A CN 200410081462 A CN200410081462 A CN 200410081462A CN 1788738 A CN1788738 A CN 1788738A
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Abstract
The present invention discloses one kind of medicine preparation containing volatile oil and medicinal supplementary material capable of solidifying the volatile oil. The medicine preparation is tablet, capsule or granule, and the medicinal supplementary material is polyglycol of average molecular weight over 2500. The volatile oil in the medicine preparation may be well maintained, and so does the medicine effect. The present invention also discloses the preparation process of the medicine preparation.
Description
Technical field
The present invention relates to medical technical field, particularly a kind of pharmaceutical preparation that contains volatile oil, and relate to the preparation method of this pharmaceutical preparation.
Background technology
When production contains the tablet of a large amount of volatile oil, shortcomings such as poor, the loose sheet of molding, difference of hardness when having tabletting more, because of this constituents can reduce intergranular cohesiveness, only remove volatile oil during production, the volatile oil content in the granule is reduced, increase cohesiveness, improve the hardness of tablet, if but volatile oil is active substance wherein, then should not remove, otherwise can cause the reduction of drug action.
When production contains the hard capsule of a large amount of volatile oil, if volatile oil without PROCESS FOR TREATMENT, then the medicine in bulk that easily hardens in the capsule makes disintegration time slow, does not reach prescription.
When production contains the granule of a large amount of volatile oil, if volatile oil without PROCESS FOR TREATMENT, then volatile oil easily scatters and disappears, and the granule drug effect is reduced.
Existing processing method generally is: adopt absorbent such as calcium sulfate two water things, calcium hydrogen phosphate, magnesium oxide, magnesium carbonate, calcium carbonate, gel aluminum hydroxide powder, active carbon to absorb volatile oil earlier before preparation; add other adjuvant again and granulate or granulate jointly, make various preparations again with other medicines.The preparation that this method is produced, very volatile when making preparation because that volatile oil combine with absorbent is not tight, cause drug effect reduction, make the effect duration shortening; And its supplementary product consumption is generally bigger, so its dose is generally also bigger after making preparation, takes inconvenience.
The method of the employing cyclodextrin inclusion compound that also has prepares cyclodextrin-volatile oil clathrate compound, but this method when commercial production owing to be difficult for that behaviour does, complex process, need special equipment, cause inefficiency, product yield is not high, loss of volatile oil is serious, and the cyclodextrin large usage quantity, the 8-10 that is generally the volatilization oil mass doubly causes dose to reach cost greatly and rises.
Also have and earlier volatile oil to be made microcapsule, make the method for various preparations again, but this method complex process needs special installation, yield is low, the cost height, and technology is full maturity not as yet.
The Polyethylene Glycol product of different mean molecule quantities can be used for medicament.The solid wax shape Polyethylene Glycol that molecular weight is high is usually used in increasing the viscosity of low-molecular-weight liquid; For being difficult for dissolved drug in the water, this product can be made the carrier of solid dispersion, to reach the solid dispersion purpose, mainly is widely used in drop pill; Polyethylene Glycol is good coating material, hydrophilic polishing material, film material and capsule material, plasticizer, lubricant and drop pill substrate, is used to prepare tablet, pill, capsule, microcapsule etc.The Polyethylene Glycol product is nontoxic, and nonirritant has good water solublity, the compatibility, lubricity, moisture retention, cementability and heat stability.Thereby, as lubricant, wetting agent, dispersant, excipient etc., in the substrate of industry such as medicine and cosmetics as ointment, suppository, the carrier of drop pill, the solvent of forming agent and injection etc., use mainly as soluble oil in tablet, consumption is generally 1-4%, and Polyethylene Glycol has in preparation very widely to be used; Few using in hard capsule and granule.
Summary of the invention
Purpose of the present invention just provides a kind of pharmaceutical preparation that contains volatile oil, thereby volatile oil preservation drug effect can be well preserved in this pharmaceutical preparation, and is easy to make tablet, capsule or granule.
Another object of the present invention provides the above-mentioned preparation method that contains the pharmaceutical preparation of volatile oil.
The technical solution adopted for the present invention to solve the technical problems is: a kind of pharmaceutical preparation that contains volatile oil, it contains volatile oil and can be with the solidified pharmaceutic adjuvant of volatile oil, the dosage form of this pharmaceutical preparation is tablet, hard capsule or granule, and wherein pharmaceutic adjuvant is that mean molecule quantity is at the Polyethylene Glycol more than 2500.
Can contain weight percentage in the said medicine preparation is the volatile oil of 5%-70% and the Polyethylene Glycol of 5%-95%.
The weight percentage of volatile oil and Polyethylene Glycol is preferably in the said medicine preparation: the volatile oil of 20%-60% and the Polyethylene Glycol of 20%-80%.
The weight percentage of Polyethylene Glycol can be 50%-80% in the said medicine preparation.
Wherein, the mean molecule quantity of Polyethylene Glycol is preferably 4000 or 6000.
Can also contain other components in the said medicine preparation, comprising ingredient and/or other pharmaceutic adjuvant etc.The other medicines composition is meant and can be used for the treatment of with contained volatile oil compatibility in the preparation or the active constituents of medicine of health purpose or drug extract etc.Other pharmaceutic adjuvant is meant that preparation tablet, hard capsule or the needed adjuvant commonly used of granule are as lubricant such as magnesium stearate etc., correctives such as sucrose, sodium cyclamate etc., coloring agent such as edible pigment, color ingot etc.According to concrete needs, tablet can also be at its surface parcel sugar-coat or film-coat.
The above-mentioned preparation method that contains the pharmaceutical preparation of volatile oil may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol of described proportioning, heat fused adds the volatile oil of described proportioning while stirring or contains other component of volatile oil, and mixing cooling back is standby;
(2) make preparation: the volatile oil after will solidifying is made preparation according to a conventional method, gets final product.
The above-mentioned pharmaceutical preparation that contains volatile oil also can prepare by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol of described proportioning, heat fused adds the volatile oil of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: add other component of described proportioning in the volatile oil after curing, make preparation behind the mixing according to a conventional method, get final product.
The dosage form of said medicine preparation is preferably tablet.
The above-mentioned medicinal tablet that contains volatile oil, except that preparing by above-mentioned two kinds of methods, can also prepare by the following method: the Polyethylene Glycol of getting described proportioning, heat fused, add the volatile oil of described proportioning while stirring or contain other component of volatile oil, inject sheet pattern tool behind the mixing while hot, take out after cooling, get final product.
Compared with prior art, the invention has the beneficial effects as follows: (1) adopts Polyethylene Glycol to solidify volatile oil, because Polyethylene Glycol has the effect of binding agent concurrently, can combine closely with volatile oil, be easy to make tablet, hard capsule or granule, also can preserve volatile oil well, thereby preserve drug effect preferably, the effect duration of prolong drug preparation.(2) compare with adopting absorbent such as calcium sulfate two water things, calcium hydrogen phosphate, magnesium oxide, magnesium carbonate, calcium carbonate, gel aluminum hydroxide powder, active carbon to absorb to granulate, make various preparations more jointly with other medicines behind the volatile oil, adopt Polyethylene Glycol to solidify volatile oil, its consumption is less relatively, other adjuvant also can use no or little, thereby can reduce dose after making preparation, taking convenience, patient is easy to accept, and also can improve patient's compliance to a certain extent.(3) its preparation method is simple to operate, need not special installation, and loss of volatile oil is few in the production process, the product yield height, and production cost is relatively low, is fit to suitability for industrialized production.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment one
The composition of present embodiment and weight percentage thereof are: 20% Oleum menthae and 80% Macrogol 4000.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum menthae after will solidifying is pulverized, and repress is made tablet and got final product.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum menthae after will solidifying is pulverized, and incapsulates shell and makes hard capsule and get final product.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum menthae crushing screening after will solidifying, the granule that is distributed into certain specification gets final product.
Embodiment two
The composition of present embodiment and weight percentage thereof are: 5% Oleum Curcumae and 95% polyethylene glycol 6000.
Make tablet by the method that may further comprise the steps: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, injects sheet pattern tool behind the mixing while hot, and the cooling back is taken out and got final product.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum Curcumae after will solidifying is pulverized, and incapsulates shell and makes hard capsule and get final product.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Curcumae crushing screening after will solidifying, the granule that is distributed into certain specification gets final product.
Embodiment three
The composition of present embodiment and weight percentage thereof are: 50% Oleum Citri Reticulatae and 50% Polyethylene Glycol 2500.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 2500 of described proportioning, heat fused adds the Oleum Citri Reticulatae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Citri Reticulatae after will solidifying is pulverized, and is pressed into tablet, wraps the thin film clothing on its surface again, gets final product.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 2500 of described proportioning, heat fused adds the Oleum Citri Reticulatae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum Citri Reticulatae after will solidifying is pulverized, and incapsulates shell and makes hard capsule and get final product.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 2500 of described proportioning, heat fused adds the Oleum Citri Reticulatae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Citri Reticulatae crushing screening after will solidifying, the granule that is distributed into certain specification gets final product.
Embodiment four
The composition of present embodiment and weight percentage thereof are: 1% Oleum Curcumae, 94% Herba Houttuyniae extract and 5% Macrogol 4000.
Wherein Herba Houttuyniae extract is the material that makes from the Chinese medicine Herba Houttuyniae by the following method: add the water that is equivalent to 8 times of amounts of medical material weight in the Herba Houttuyniae medical material, decoction is extracted 2 times, merges extracted twice liquid, and the concentrated and dry dry extract that gets gets final product.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Curcumae after will solidifying is pulverized, and adds the Herba Houttuyniae extract of described proportioning, granulates behind the mixing, is pressed into tablet, at its surface parcel glace or film-coat, gets final product again.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum Curcumae after will solidifying is pulverized, and adds the Herba Houttuyniae extract of described proportioning, and mixing is granulated, and incapsulates shell and makes hard capsule and get final product.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Curcumae after will solidifying is pulverized, and adds the Herba Houttuyniae extract of described proportioning, granulates behind the mixing and sieves, and the granule that is distributed into certain specification gets final product.
Embodiment five
The composition of present embodiment and weight percentage thereof are: 10% Oleum Curcumae, 70% Herba Houttuyniae extract and 20% polyethylene glycol 6000.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and is standby behind the mixing;
(2) make preparation: pulverize the Oleum Curcumae cooling back after will solidifying, and adds Herba Houttuyniae extract, and mix homogeneously is pressed into tablet, at its surface parcel glace or film-coat, gets final product again.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum Curcumae after will solidifying is pulverized, and adds Herba Houttuyniae extract, and mix homogeneously incapsulates shell and makes hard capsule and get final product.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the polyethylene glycol 6000 of described proportioning, heat fused adds the Oleum Curcumae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum Curcumae after will solidifying is pulverized, and adds Herba Houttuyniae extract, and mix homogeneously sieves, and the granule that is distributed into certain specification gets final product.
Embodiment six
The composition of present embodiment and weight percentage thereof are: 60% Oleum menthae, 35% Polyethylene Glycol 2500,3% sodium cyclamate and 2% indigo.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 2500 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum menthae after will solidifying is pulverized, and adds the sodium cyclamate of described proportioning and indigo, granulates behind the mixing, is pressed into tablet, again at its surface parcel glace or film-coat.Get final product.
Embodiment seven
The composition of present embodiment and weight percentage thereof are: 8% Oleum menthae, 31% Calculus Bovis, 60% Polyethylene Glycol 8000 and 1% magnesium stearate.
Make tablet by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 8000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum menthae after will solidifying is pulverized, and adds the Calculus Bovis and the magnesium stearate of described proportioning, granulates behind the mixing, is pressed into tablet, wraps the thin film clothing on its surface again.Get final product.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol 8000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum Curcumae after will solidifying is pulverized, and adds the Calculus Bovis and the magnesium stearate of described proportioning, and mixing is granulated, and incapsulates shell and makes hard capsule and get final product.
Embodiment eight
The composition of present embodiment and weight percentage thereof are: 10% Oleum menthae, 10% Oleum Blumeae Balsamiferae, 30% dextrin, 30% sucrose and 20% Macrogol 4000.
Make granule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum menthae and the Oleum Blumeae Balsamiferae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: Oleum menthae after the curing of inciting somebody to action and Oleum Blumeae Balsamiferae are pulverized, and add the dextrin and the sucrose of described proportioning, granulate behind the mixing and sieve, and the granule that is distributed into certain specification gets final product.
Embodiment nine
The composition of present embodiment and weight percentage thereof are: 70% Oleum menthae, 30% Macrogol 4000.
Make hard capsule by the method that may further comprise the steps:
(1) solidify volatile oil: get the Macrogol 4000 of described proportioning, heat fused adds the Oleum menthae of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: the Oleum menthae crushing screening after the curing of inciting somebody to action, the hungry area softgel shell of packing into then, the hard capsule of making certain specification gets final product.
Claims (10)
1, a kind of pharmaceutical preparation that contains volatile oil, it contains volatile oil and can be with the solidified pharmaceutic adjuvant of volatile oil, it is characterized in that: the dosage form of this pharmaceutical preparation is tablet, hard capsule or granule, and wherein pharmaceutic adjuvant is that mean molecule quantity is at the Polyethylene Glycol more than 2500.
2, the pharmaceutical preparation that contains volatile oil according to claim 1 is characterized in that: containing weight percentage in the described pharmaceutical preparation is the volatile oil of 5%-70% and the Polyethylene Glycol of 5%-95%.
3, the pharmaceutical preparation that contains volatile oil according to claim 1 is characterized in that: containing weight percentage in the described pharmaceutical preparation is the volatile oil of 20%-60% and the Polyethylene Glycol of 20%-80%.
4, the pharmaceutical preparation that contains volatile oil according to claim 3 is characterized in that: contain the Polyethylene Glycol that weight percentage is 50%-80% in the described pharmaceutical preparation.
5, the pharmaceutical preparation that contains volatile oil according to claim 1 is characterized in that: the mean molecule quantity of described Polyethylene Glycol is 4000 or 6000.
6, the pharmaceutical preparation that contains volatile oil according to claim 1 is characterized in that: also contain other components in the described pharmaceutical preparation, comprising ingredient and/or other pharmaceutic adjuvant.
7, according to each described pharmaceutical preparation that contains volatile oil in the claim 1 to 6, it is characterized in that: the dosage form of described pharmaceutical preparation is a tablet.
8, each described preparation method that contains the pharmaceutical preparation of volatile oil among a kind of claim 1-6 may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol of described proportioning, heat fused adds the volatile oil of described proportioning while stirring or contains other component of volatile oil, and mixing cooling back is standby;
(2) make preparation: the volatile oil after will solidifying is made preparation according to a conventional method, gets final product.
9, the described preparation method that contains the pharmaceutical preparation of volatile oil of a kind of claim 6 may further comprise the steps:
(1) solidify volatile oil: get the Polyethylene Glycol of described proportioning, heat fused adds the volatile oil of described proportioning while stirring, and mixing cooling back is standby;
(2) make preparation: add other component of described proportioning in the volatile oil after curing, make preparation behind the mixing according to a conventional method, get final product.
10, the described preparation method that contains the pharmaceutical preparation of volatile oil of a kind of claim 7, its practice is: the Polyethylene Glycol of getting described proportioning, heat fused, add the volatile oil of described proportioning while stirring or contain other component of volatile oil, inject sheet pattern tool behind the mixing while hot, take out after cooling, get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2004100814627A CN1788738B (en) | 2004-12-14 | 2004-12-14 | Medicinal preparation containing volatile oil and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2004100814627A CN1788738B (en) | 2004-12-14 | 2004-12-14 | Medicinal preparation containing volatile oil and preparing method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN1788738A true CN1788738A (en) | 2006-06-21 |
| CN1788738B CN1788738B (en) | 2011-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2004100814627A Expired - Fee Related CN1788738B (en) | 2004-12-14 | 2004-12-14 | Medicinal preparation containing volatile oil and preparing method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055080A (en) * | 2013-01-06 | 2013-04-24 | 刘炜 | Oral solid preparation for treating diseases of digestive tracts |
| CN104958263A (en) * | 2015-07-15 | 2015-10-07 | 江苏中兴药业有限公司 | Method for wrapping essential oil with low-temperature micropowder |
| CN111387460A (en) * | 2019-09-19 | 2020-07-10 | 北京诺康达医药科技股份有限公司 | Edible spice mixture, microcapsule powder, and preparation method and application thereof |
| CN112121025A (en) * | 2019-06-24 | 2020-12-25 | 翰宇药业（武汉）有限公司 | Isosorbide mononitrate sustained-release tablet and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1135996C (en) * | 2000-06-09 | 2004-01-28 | 红桃开集团股份有限公司 | Chinese medicine for treating coronary heart disease and angina pectoris and its preparing process |
| CN1430981A (en) * | 2002-12-04 | 2003-07-23 | 张忠义 | Zedoary oil product of virus safe medicine and its preparing method |
-
2004
- 2004-12-14 CN CN2004100814627A patent/CN1788738B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055080A (en) * | 2013-01-06 | 2013-04-24 | 刘炜 | Oral solid preparation for treating diseases of digestive tracts |
| CN104958263A (en) * | 2015-07-15 | 2015-10-07 | 江苏中兴药业有限公司 | Method for wrapping essential oil with low-temperature micropowder |
| CN104958263B (en) * | 2015-07-15 | 2018-07-06 | 江苏中兴药业有限公司 | A kind of method of low-temperature fine powder package volatile oil |
| CN112121025A (en) * | 2019-06-24 | 2020-12-25 | 翰宇药业（武汉）有限公司 | Isosorbide mononitrate sustained-release tablet and preparation method thereof |
| CN112121025B (en) * | 2019-06-24 | 2022-05-31 | 翰宇药业（武汉）有限公司 | Isosorbide mononitrate sustained-release tablet and preparation method thereof |
| CN111387460A (en) * | 2019-09-19 | 2020-07-10 | 北京诺康达医药科技股份有限公司 | Edible spice mixture, microcapsule powder, and preparation method and application thereof |
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| Publication number | Publication date |
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| CN1788738B (en) | 2011-07-13 |
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Granted publication date: 20110713 Termination date: 20111214 |