CN101347388A - Oral cavity nursing agent and preparation technique thereof - Google Patents
Oral cavity nursing agent and preparation technique thereof Download PDFInfo
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- CN101347388A CN101347388A CNA2008100265064A CN200810026506A CN101347388A CN 101347388 A CN101347388 A CN 101347388A CN A2008100265064 A CNA2008100265064 A CN A2008100265064A CN 200810026506 A CN200810026506 A CN 200810026506A CN 101347388 A CN101347388 A CN 101347388A
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Abstract
The invention provides a dental conditioning agent containing biologic activity hydroxyapatite or nano-hydroxyapatite and nano silver ion. The dental conditioning agent used for preventing and curing oral diseases comprises 5-10 weight percent of the biologic activity hydroxyapatite or the nano-hydroxyapatite and 1-5 weight percent of the nano silver ion. The effective repairing effect of the biologic activity hydroxyapatite or the nano-hydroxyapatite for the wound surface of the osseous tissue and the soft tissue of the human body and the strong sterilization function of the nano silver ion are used for preventing and curing a plurality of dental diseases, including decayed tooth, hemodia, tooth mobility, periodonititis, gingivitis, gingival atrophy, oral ulcer, halitosis and the pathologic change of oral mucosa, etc. And the dental conditioning agent can be made into various medicament forms, such as powdered drug, paste, teeth patch, cataplasm, aqueous solution, jellies and mouth wash, and the like, according to needs, thus facilitating the daily life use and the clinical use. In addition, the dental conditioning agent has the advantages of good curative effect, intensive medicament forms, easy manufacture, without drug tolerance, safety and no irritation.
Description
Technical field
The present invention relates to a kind of oral cavity nursing agent that is used to prevent and treat oral disease, also relate to its preparation method, belong to clinical treatment articles for use and cosmetics of everyday use.
Background technology
The human oral cavity disease includes multiple diseases such as dental caries, hemodia, odontoseisis, periodontitis, gingivitis, gingival atrophy, oral ulcer, halitosis, oral mucosa pathological changes.
Biological activity hydroxyapatite (HA) (or nanometer hydroxyapatite) worldwide has the applicating history of decades clinically as oral cavity osseous tissue and soft tissue repair material and orthopaedics bone renovating material.One of its great characteristic is when biological activity hydroxyapatite or nanometer hydroxyapatite contact with human body fluid, the reaction of generation accelerated surface, discharge silicon, phosphorus, calcium, sodium ion rapidly, and generate a kind of activity hydroxy apatite shelf layer, the altered surface of silicon, phosphorus, calcium, sodium ion that discharges is electronegative, can get started required structoure of the human body matrix such as somatomedin, the collagen fiber albumen etc. of absorption tissue regeneration; Biological activity hydroxyapatite or nanometer hydroxyapatite granule also are adsorbed on bone and the soft tissue simultaneously, form a new complex tissue with absorption structoure of the human body matrix, thereby reach the purpose of organizing mineralising to repair.
Discover that biological activity hydroxyapatite or nanometer hydroxyapatite not only have the effect that promotes tissue growth and remineralization, also have the effect that suppresses the oral cavity bacterium.Biological activity hydroxyapatite or nanometer hydroxyapatite have the comprehensive function of desensitization, anti-caries, strengthening tooth, resist gingivitis hemostasis, prevention oral ulcer, and are confirmed in clinical trial.New research shows that simultaneously biological activity hydroxyapatite or nanometer hydroxyapatite are when contacting the reaction of generation accelerated surface with human body fluid, and its local pH value has the effect of various noxious bacteria in effective inhibition human body fluid between 7.2-8.5.(referring to number of patent application: 200410012897.6, denomination of invention: " bioactive glass treatment gingivitis, the effect of dental hemorrhage and releasing odontoseisis symptom ", number of patent application: 200410018370.4, denomination of invention: " application of bioactivity glass in preparation treatment ulcer and erosive wound dressing ", publication number: CN1213355, denomination of invention: " bioactive glass compositions and the Therapeutic Method that uses bioactivity glass ", number of patent application 200410046143.2, denomination of invention: " a kind of novel nanoscale toothpaste additive and synthetic method thereof ".)
Nano-silver ionic then can kill 650 various bacteria in several minutes, (SH) combine, make enzyme deactivation, the blocking-up bacterial metabolism is choked to death it with the oxygen metabolism enzyme by directly entering thalline for it; Nanometer silver can with the DNA combination in pathogenic bacterium or the spore, cause the dna structure degeneration, suppress it and duplicate, make the pathogenic bacterium inactivation; Nanometer silver also can change the permeability of thalline endochylema inner mitochondria film, quickens the deactivation of thalline, and the sterilization mechanism that it is unique makes nanometer silver at low concentration kill pathogenic organisms rapidly just.
Summary of the invention
The objective of the invention is to propose a kind of oral cavity nursing agent and preparation technology thereof that biological activity hydroxyapatite or nanometer hydroxyapatite add nano-silver ionic that contain, it can carry out antibacterial, sterilization, sterilization and repair osseous tissue, soft tissue the human oral cavity disease, be used for preventing and treating the multiple disease such as dental caries, hemodia, odontoseisis, periodontitis, gingivitis, gingival atrophy, oral ulcer, halitosis, oral mucosa pathological changes of human oral cavity, clinical effectiveness is obvious, the cure rate height.
For achieving the above object, technical scheme of the present invention is as follows:
Oral cavity nursing agent of the present invention comprises the biological activity hydroxyapatite of the component of following percentage by weight: 5-10% or the nano-silver ionic of nanometer hydroxyapatite and 1-5%.
Described nursing agent includes powder, unguentum, tooth patch, paste, aqueous solvent, gel and collutory dosage form.
Wherein, the preparation process of powder is:,, pack during weight is packed the PVC container in accordance with regulations biological activity hydroxyapatite or nano hydroxyapatite powder and nano silver powder mix homogeneously by proportioning, through CO60 irradiation sterilization warehouse-in, get final product.
The preparation process of unguentum is: by proportioning urea peroxide, calcium hydrogen phosphate, lauryl alcohol, sodium sulfate, hydroxy methocel, glucide, glycerol, spice, the herbal raw material of biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder and food stage is made into the toothpaste agent.
The preparation process of tooth patch is: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with bio-adhesive agent, urea peroxide, carbomer, glycerol, spice, the herbal raw material of food stage, be uniformly coated on the PE thin film of food stage, close sticking with the polyester plastics dura mater carrying material one side, 40-60 ℃ of oven dry down, montage becomes to reinstall in the PVC bag after the moderate size and packs, and puts in storage through the CO60 irradiation sterilization.
The preparation process of paste is: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with urea peroxide, glycerol, spice, carbomer, glucide, the herbal raw material of food stage, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.
The preparation process of gel is: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into gel with bio-degradable gel, carbomer, glycerol, glucide, spice, the herbal raw material of food stage, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.
The preparation process of collutory is: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with glycerol, spice, glucide, the herbal raw material of food stage, inject injection vessel or extrude container and pack, put in storage through the CO60 irradiation sterilization.
Biological activity hydroxyapatite of the present invention or nanometer hydroxyapatite and nanometer silver are commercially available pharmaceutical grade product.
Novel oral cavity nursing agent of the present invention, make full use of the efficient repair of biological activity hydroxyapatite or nanometer hydroxyapatite to body bone tissue and soft tissue wound surface, and the potent biocidal efficacies that utilizes nano-silver ionic, the dental caries of preventing and treating that is used for human oral cavity, hemodia, odontoseisis, periodontitis, gingivitis, gingival atrophy, oral ulcer, halitosis, the oral mucosa pathological changes, and sterilization, antibacterial, multiple diseases such as sterilization, effect is remarkable, can be prepared into various powder according to clinical needs, unguentum, the tooth patch, paste, aqueous solvent, gel, dosage forms such as collutory make things convenient for the clinical use of daily life and doctor.
Nano-silver ionic of the present invention has following characteristic:
1, broad-spectrum antiseptic
Nanometer silver can kill microorganisms such as most of antibacterials of being in contact with it, fungus, mycete, spore, verify through authoritative institutions such as U.S. FDA, Switzerland SGS laboratory and Chinese Military Medical Science Institutes, it has comprehensive antibacterial activity to drug resistance pathogen such as drug resistance escherichia coli, drug resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, micrococcus scarlatinae, anaerobe etc., Candida albicans and other G+, G-pathogenic bacterium are all had killing action, and chlamydia, gonococcus, fungus also have powerful bactericidal action.
2, permeability is strong
The body surface tissue has been covered with duct (pore, pore etc.), the important channel when being treated in vitro, and its diameter generally is micron order (10-6m), so the grain diameter of ingredient must could enter human body significantly less than channel diameter unblockedly.And the particle diameter of common external medicine preparation generally is micron order (10-6m), has skin barrier, therefore is difficult to the rapid permeability epidermis and arrives focus.And nanometer silver (10-9m) has superpower permeability, can penetrate epidermis rapidly and infiltrate subcutaneously, and common bacteria, obstinate antibacterial, drug-resistant bacteria and fungus-caused tissue infection than the depths are all had good bactericidal action, does not have the skin barrier of common drug fully.
3, promote healing
Exchanging mechanism between nanometer silver and the zinc ion, can reduce the zinc ion of wound surface, and then the release of promotion calcium ion, increase the wound surface calcium ion, promote the epithelial cell regeneration of wound, have granulation promoting, convergence, promotion tissue repair and regenerated effect, quicken the recovery of wound surface and rotten to the corn face, avoid the generation of cicatrix, and reduce the sickness rate once more at this position.
4, have no drug resistance
Different with the antibiotic sterilization mechanism, nanometer silver is the physical property sterilization, and it also can directly enter the thalline killing bacteria by the directly cell membrane sterilization of contact pathogenic bacteria, causes pathogenic bacterium can't produce chemical sproof bacterial strain of future generation.
5, safe, nontoxic, non-stimulated
Because the physical property sterilization mechanism of nanometer silver uniqueness, chemical reaction does not take place in the sterilization process and produce other compositions, after finishing sterilization process, nanometer silver is got rid of external with dead bacterium by different body systemes, in human body, do not form and accumulate, safer on using.Through Academy of Military Medicine, PLA's verification experimental verification: mice is at oral maximum tolerated dose 925mg/kg, when promptly being equivalent to 4625 times of clinical using dosage, do not have any toxic reaction; In the skin irritation test of rabbit, do not find any irritant reaction yet.
The present invention compared with prior art has following obvious improvement and outstanding characteristics:
1, clinical effectiveness is remarkable, the cure rate height.
2, technology is simple, produces easily.
3, dosage form is various, and it is wide to be suitable for the crowd.
4, have no drug resistance, safe, nontoxic, non-stimulated.
The specific embodiment
Embodiment one:
Powder: biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) is pressed 3 with nanometer silver 5-15nm powder body: 1---5: 1 part by weight mix homogeneously, weight is packed in the PVC container in accordance with regulations, pack, put in storage through the CO60 irradiation sterilization.Disinfecting cotton swab need only be got an amount of product and directly is applied to the affected part and gets final product with distilled water or normal saline eliminating dampness by diuresis are sticking again during use.
Embodiment two:
Unguentum: with biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) powder body 5-10%, add nanometer silver 5-15nm powder body 1-5%, be made into the toothpaste agent with technology according to a certain percentage with raw materials such as the urea peroxide of food stage, calcium hydrogen phosphate, lauryl alcohol, sodium sulfate, hydroxy methocel, glucide, glycerol, spice, Chinese herbal medicine.
Embodiment three:
Tooth patch: with biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) powder body 5-10%, add nanometer silver 5-15nm powder body 1-5%, be mixed into paste with technology according to a certain percentage with raw materials such as the bio-adhesive agent of food stage, urea peroxide, carbomer, glycerol, spice, Chinese herbal medicine, be uniformly coated on the PE thin film of food stage, close sticking with the polyester plastics dura mater carrying material one side, under 40-60 ℃ of temperature, dry, montage becomes size about 1.5*7cm, reinstall in the PVC bag and pack, put in storage through the CO60 irradiation sterilization.It need only be taken out during use, the one side of PE thin film band paste directly is adjacent to dental surface get final product, take off after 10-30 minute.
Embodiment four:
Paste: with biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) powder body 5-10%, add nanometer silver 5-15nm powder body 1-5%, be mixed into paste with technology according to a certain percentage with raw materials such as the urea peroxide of food stage, glycerol, spice, carbomer, glucide, Chinese herbal medicine, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.Need only or be expressed in the dens supporter groove the paste product injection during use, be coated with all, the patient stings and annotates dens supporter 3-10 minute was that available toothbrush or clear water are washed off.
Embodiment five:
Gel: with biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) powder body 5-10%, add nanometer silver 5-15nm powder body 1-5%, be mixed into gel with technology according to a certain percentage with raw materials such as the bio-degradable gel of food stage, carbomer, glycerol, glucide, spice, Chinese herbal medicine, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.Need only or extrude in right amount with gel product injection during use, get product and directly be applied to the affected part with disinfecting cotton swab is sticking.
Embodiment six:
Collutory: with biological activity hydroxyapatite (HA) 10-100um (or nanometer hydroxyapatite 5-15nm) powder body 5-10%, add nanometer silver 5-15nm powder body 1-5%, be mixed into paste with technology according to a certain percentage with raw materials such as the glycerol of food stage, spice, glucide, Chinese herbal medicine, inject injection vessel or extrude container and pack, put in storage through the CO60 irradiation sterilization.Need only or be expressed in the cup paste product 2-3G injection in use, with the dissolving of 20-100ML clear water, gargling gets final product for 3-5 time.
Claims (8)
1, a kind of oral cavity nursing agent is characterized in that, it comprises the component of following percentage by weight: biological activity hydroxyapatite or nanometer hydroxyapatite 5-10%, nano-silver ionic 1-5%.
2, oral cavity nursing agent according to claim 1 is characterized in that, described nursing agent dosage form comprises powder, unguentum, tooth patch, paste, aqueous solvent, gel, collutory.
3, oral cavity nursing agent according to claim 2, it is characterized in that, the preparation process of described powder comprises: press proportioning with biological activity hydroxyapatite or nano hydroxyapatite powder and nano silver powder mix homogeneously, weight is packed in the PVC container in accordance with regulations, pack, through CO60 irradiation sterilization warehouse-in, get final product.
4, oral cavity nursing agent according to claim 2, it is characterized in that the preparation process of described unguentum comprises: urea peroxide, calcium hydrogen phosphate, lauryl alcohol, sodium sulfate, hydroxy methocel, glucide, glycerol, spice, the herbal raw material of biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder and food stage is made into the toothpaste agent by proportioning.
5, oral cavity nursing agent according to claim 2, it is characterized in that, the preparation process of described tooth patch comprises: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with bio-adhesive agent, urea peroxide, carbomer, glycerol, spice, the herbal raw material of food stage, be uniformly coated on the PE thin film of food stage, close sticking with the polyester plastics dura mater carrying material one side, 40-60 ℃ of oven dry down, montage becomes to reinstall in the PVC bag after the moderate size and packs, and puts in storage through the CO60 irradiation sterilization.
6, oral cavity nursing agent according to claim 2, it is characterized in that, the preparation process of described paste comprises: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with urea peroxide, glycerol, spice, carbomer, glucide, the herbal raw material of food stage, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.
7, oral cavity nursing agent according to claim 2, it is characterized in that, the preparation process of described gel comprises: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into gel with bio-degradable gel, carbomer, glycerol, glucide, spice, the herbal raw material of food stage, inject syringe or extrude container and pack, put in storage through the CO60 irradiation sterilization.
8, oral cavity nursing agent according to claim 2, it is characterized in that, the preparation process of described collutory comprises: by proportioning biological activity hydroxyapatite or nano hydroxyapatite powder, nano silver powder are mixed into paste with glycerol, spice, glucide, the herbal raw material of food stage, inject injection vessel or extrude container and pack, put in storage through the CO60 irradiation sterilization.
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| CNA2008100265064A CN101347388A (en) | 2008-02-27 | 2008-02-27 | Oral cavity nursing agent and preparation technique thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631292A (en) * | 2012-05-09 | 2012-08-15 | 阮仕星 | Elastic anhydrous high-thickness gel sticking film for whitening teeth |
| CN103405401A (en) * | 2013-08-08 | 2013-11-27 | 余秀民 | Specific paper patch used for treating periodontosis |
| CN103961371A (en) * | 2014-05-08 | 2014-08-06 | 北京刷新活力健康科技有限公司 | Dental treatment medicine having multiple effects and composition thereof |
| CN104248775A (en) * | 2014-09-22 | 2014-12-31 | 片仔癀（上海）生物科技研发有限公司 | Hydroxyapatite-chitosan compound gel and preparation process and application thereof |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
| CN107898652A (en) * | 2017-07-06 | 2018-04-13 | 南昌登特科技有限公司 | A kind of whitening strips containing active carbon loading silver |
| CN108379087A (en) * | 2018-03-30 | 2018-08-10 | 徐崇明 | A kind of filling paste and preparation method thereof for dental pulp expectant treatment |
| CN110169948A (en) * | 2019-06-17 | 2019-08-27 | 北京幸福益生再生医学科技有限公司 | A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof |
| CN113208936A (en) * | 2021-04-13 | 2021-08-06 | 赵奇 | Whitening gel and using method thereof |
-
2008
- 2008-02-27 CN CNA2008100265064A patent/CN101347388A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102631292A (en) * | 2012-05-09 | 2012-08-15 | 阮仕星 | Elastic anhydrous high-thickness gel sticking film for whitening teeth |
| CN103405401A (en) * | 2013-08-08 | 2013-11-27 | 余秀民 | Specific paper patch used for treating periodontosis |
| CN103961371A (en) * | 2014-05-08 | 2014-08-06 | 北京刷新活力健康科技有限公司 | Dental treatment medicine having multiple effects and composition thereof |
| CN104248775A (en) * | 2014-09-22 | 2014-12-31 | 片仔癀（上海）生物科技研发有限公司 | Hydroxyapatite-chitosan compound gel and preparation process and application thereof |
| CN104248775B (en) * | 2014-09-22 | 2015-11-25 | 片仔癀（上海）生物科技研发有限公司 | A kind of hydroxyapatite-chitosan plural gel and preparation technology thereof and purposes |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
| CN107898652A (en) * | 2017-07-06 | 2018-04-13 | 南昌登特科技有限公司 | A kind of whitening strips containing active carbon loading silver |
| CN108379087A (en) * | 2018-03-30 | 2018-08-10 | 徐崇明 | A kind of filling paste and preparation method thereof for dental pulp expectant treatment |
| CN110169948A (en) * | 2019-06-17 | 2019-08-27 | 北京幸福益生再生医学科技有限公司 | A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof |
| CN113208936A (en) * | 2021-04-13 | 2021-08-06 | 赵奇 | Whitening gel and using method thereof |
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Open date: 20090121 |