CN110169948A - A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof - Google Patents

A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof Download PDF

Info

Publication number
CN110169948A
CN110169948A CN201910524322.9A CN201910524322A CN110169948A CN 110169948 A CN110169948 A CN 110169948A CN 201910524322 A CN201910524322 A CN 201910524322A CN 110169948 A CN110169948 A CN 110169948A
Authority
CN
China
Prior art keywords
gel
solution
medium
formula ratio
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910524322.9A
Other languages
Chinese (zh)
Inventor
刘明东
胡方
仇越秀
余玲华
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Happy Regenerative Medical Science And Technology Co Ltd
Original Assignee
Beijing Happy Regenerative Medical Science And Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Happy Regenerative Medical Science And Technology Co Ltd filed Critical Beijing Happy Regenerative Medical Science And Technology Co Ltd
Priority to CN201910524322.9A priority Critical patent/CN110169948A/en
Publication of CN110169948A publication Critical patent/CN110169948A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Abstract

The invention belongs to medical material tech field, in particular to the canker sore of a kind of material containing bioactive minerals repairs gel and preparation method thereof.The raw material for repairing gel is by mass percentage, comprising: bioadhesive gel matrix 0.05%-5%, bioactive minerals material 0.05%-5%, dispersing agent 3%-20%, pH adjusting agent 0.01%-1%, medium surplus.Canker sore of the invention repairs gel; it can be according to the surface of a wound size when use; appropriate gel is taken to be applied to the canker sore surface of a wound; 30s or so can form one layer of adhesiveness protective film; perfection fitting ulcer wound surface; with excellent adhesiveness, closure, biocompatibility, be effectively prevented bacterium enters to invade stimulation of the foreign matter to ulcer surface and mucosal tissue.Present component safety, the ingredients such as hormone-free, antibiotic avoid drug-induced adverse reaction, and are not necessarily to special instrument, easy to operate, wide indications.

Description

A kind of canker sore of the material containing bioactive minerals repairs gel and its preparation Method
Technical field
The invention belongs to medical material tech field, in particular to the canker sore of a kind of material containing bioactive minerals Repair gel and preparation method thereof.
Background technique
Canker sore is a kind of superficial ulcer betided on oral mucosa, also known as " aphtha ", often hair in tongue, lip, cheek, The positions such as vestibular ditch, soft palate, and have periodically, the disease incidence in general population is not less than 10%, in specific crowd, suffers from Sick rate is up to 60%.Patient often feels in great pain, particularly evident when especially encountering the foods such as sour, salty, hot and cold, serious shadow Ring the life and work for arriving patient.
Currently, the product clinically used is powder, paste, film, gargle etc., main purpose is relieved pain with anti-inflammatory and is It is main, although the treatment to canker sore has certain curative effect, do not have the ability of the growth of induced tissue cell, for bursting Reparation, the healing in ulcer face, lack enough facilitations；And the product of certain repair can be played, and mostly containing ground The drug ingedients such as Sai meter Song, metronidazole；Along with existing product have focal adhesion it is poor, easily by saliva washout, using inadequate The disadvantages of facilitating, the movement etc. of patient's masseter when speaking, feeding, the therapeutic effect of these products receive certain influence； Such as powder canker sore product, after being applied to affected part, quickly as saliva is lost, when in use, foreign body sensation is stronger for film, and The shape of film causes the two perfect cannot be bonded with the shape difference of ulcer surface.
Therefore, in the scientific research and practice of the department of stomatology, needing to develop a kind of can form physics screened film, promote cell raw Novel canker sore that is long, accelerating wound healing, ingredient safety, good effect, patient's physiological pain few repairs gel.
Summary of the invention
The object of the present invention is to provide a kind of canker sore of material containing bioactive minerals to repair gel and its preparation Method.The reparation gel can wound healing, and screened film, ingredient safety, good effect can be formed.
To achieve the goals above, the present invention adopts the following technical scheme:
A kind of canker sore reparation gel of the material containing bioactive minerals, the raw material for repairing gel press quality hundred Score meter, comprising:
As preferred embodiment, the raw material for repairing gel is by mass percentage, further includes:
Corrigent 0.01%-0.5%
Bacteriostatic agent 0.01%-0.5%.
As preferred embodiment, the bioadhesive gel matrix is polyacrylic materials, cellulose family material The combination of one or more of material, chitosan, polyvinyl alcohol, sodium alginate；Preferably, the polyacrylic materials are selected from card The mixture of one or more of wave nurse, polycarbophil；It is fine that the cellulose material is selected from hydroxypropyl cellulose, ethoxy Tie up the mixture of one or more of element, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose.
As preferred embodiment, the dispersing agent is selected from propylene glycol, glycerine, polyethylene glycol, Tween-80, anhydrous One or more of ethyl alcohol mixture.
As preferred embodiment, the pH adjusting agent is selected from citric acid, sodium citrate, triethanolamine, biphosphate The mixture of one or more of salt, phosphoric acid hydrogen disalt, lactic acid；The dihydric phosphate particular certain cancers or sylvite, the phosphorus Sour hydrogen disalt particular certain cancers or sylvite.
As preferred embodiment, the corrigent is any one in menthol, borneol, saccharin sodium, eucalyptus oil Kind or several mixtures；The antibacterial agent is selected from methylparaben, ethylparaben, sodium benzoate, potassium sorbate, sodium lactate One or more of mixture.
As preferred embodiment, the medium is dehydrated alcohol and water, in the medium, the volume of dehydrated alcohol Percentage is 65%-95%.
As preferred embodiment, the bioactive minerals material be selected from bioactivity silicon, bioactivity glass, The mixture of one or more of hydroxyapatite；Preferably, the bioactivity silicon has the inorganic of three-dimensional net structure Silicon materials, the silica including 40-70wt%, the oxide of the phosphorus of 30-60wt%, calcium and sodium；Wherein silica is formed Tridimensional network, calcium ion and phosphonium ion are orderly distributed among three-dimensional netted silicon atom.Preferably, the bioactivity glass It is living that glass is selected from 45S5 bioactive glass powder, 58S bioactive glass powder, 70S bioactive glass powder, 77S biology At least one of property glass powder.
When not containing corrigent and bacteriostatic agent in the raw material for repairing gel, preparation method, comprising the following steps:
Solution A preparation steps: the bioadhesive gel matrix is well-dispersed in 0.65-0.80 times of formula ratio In the dispersing agent, the medium is then added and sufficiently dissolves, obtains solution A；When the bioadhesive gel matrix needs to add When heat of solution, solution A is prepared as follows: the bioadhesive gel matrix is well-dispersed in formula ratio In 0.65-0.80 times of the dispersing agent, the water being then added in the medium of formula ratio sufficiently dissolves, and obtains solution A, preferably Ground, the temperature heated during the dissolution are 65-95 DEG C, preferably 70 DEG C；
Then plus the solution miscible step: dispersing the bioactive minerals material in remaining dispersing agent, A；When the bioadhesive gel matrix needs to dissolve by heating, it is also necessary to add anhydrous in the medium of formula ratio Ethyl alcohol；It is sufficiently stirred to obtain mixed liquor later；
It adjusts pH step: pH adjusting agent being added in Xiang Suoshu mixed liquor, adjusting pH is 3-8；
It stands de-foaming steps: after the mixed liquor after adjusting pH value is stood defoaming, obtaining the reparation gel.
When containing corrigent and bacteriostatic agent in the raw material for repairing gel, preparation method, comprising the following steps:
Solution A preparation steps: the bioadhesive gel matrix is well-dispersed in 0.65-0.80 times of formula ratio In the dispersing agent, 0.7-0.9 times of the medium that formula ratio is then added sufficiently dissolves, and obtains solution A；When the biological slime When attached property gel-type vehicle needs to dissolve by heating, solution A is prepared as follows: the bioadhesive gel matrix is abundant It is scattered in the dispersing agent of 0.65-0.80 times of formula ratio, the water being then added in the medium of formula ratio is sufficiently molten Solution, obtains solution A, it is preferable that the temperature heated during the dissolution is 65-95 DEG C, preferably 70 DEG C；
Solution B preparation steps: the corrigent or/and bacteriostatic agent are dissolved in the remaining medium, then with it is described Solution A is uniformly mixed, and obtains solution B；When the bioadhesive gel matrix needs to dissolve by heating, the remaining medium Refer to the dehydrated alcohol in the medium of formula ratio；
Miscible step: dispersing the bioactive minerals material in remaining dispersing agent, and then plus the B is molten Liquid, and be sufficiently stirred, obtain mixed liquor；
It adjusts pH step: pH adjusting agent being added in Xiang Suoshu mixed liquor, adjusting pH is 3-8；
It stands de-foaming steps: after the mixed liquor after adjusting pH value is stood defoaming, obtaining the reparation gel.
Compared with prior art, technical benefits of the invention is as follows:
1, the canker sore of the material produced by the present invention containing bioactive minerals repairs gel, and when use can be according to the surface of a wound Size, takes appropriate gel to be applied to the canker sore surface of a wound, and 30s or so can form one layer of adhesiveness protective film, perfection fitting Ulcer wound surface has excellent adhesiveness, closure, biocompatibility, and be effectively prevented bacterium enters to invade foreign matter to ulcer The stimulation in face and mucosal tissue.Meanwhile the bioactive minerals material in gel is after contacting the surface of a wound, can promote growth because The proliferation of son secretion and cell, can promote wound repair ability, accelerate the healing rate of the surface of a wound, to more efficiently treat Canker sore.
2, present component safety, the ingredients such as hormone-free, antibiotic avoid drug-induced adverse reaction, and nothing Special instrument is needed, easy to operate, wide indications.
3, the selection proportion of each raw material of the invention is reasonable, acts synergistically, especially medium, bioadhesive gel base Matter, bioactive minerals material are fitted to each other between this three, further improve the comprehensive performance of renovation agent jointly.
Detailed description of the invention
Fig. 1: the therapeutic effect diagram in the animal experiment of test case, after 5 days.
Specific embodiment
For further understanding of the invention, the present invention will be further described combined with specific embodiments below, is retouched The embodiment stated is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, originally Field technical staff every other embodiment obtained without making creative work, belongs to protection of the present invention Range.
In a first aspect, the canker sore that the present invention provides a kind of material containing bioactive minerals repairs gel, raw material By mass percentage, comprising:
As preferred embodiment, the raw material of above-mentioned reparation gel is by mass percentage, further includes:
Corrigent 0.01%-0.5%
Bacteriostatic agent 0.01%-0.5%.
Illustratively, the mass percent of above-mentioned bioadhesive gel matrix can for 0.05%, 0.1%, 0.3%, 0.5%, the arbitrary value or any number in 0.75%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% Range, the mass percent of above-mentioned bioactive minerals material can for 0.05%, 0.1%, 0.3%, 0.5%, 0.75%, 1%, the arbitrary value or any number range in 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, above-mentioned dispersion The mass percent of agent can be the arbitrary value in 3%, 5%, 8%, 10%, 12%, 15%, 17%, 20% or any number Range, the mass percent of above-mentioned pH adjusting agent can for 0.01%, 0.03%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 0.55%, 0.6%, 0.65%, 0.7%, 0.75%, 0.8%, the arbitrary value or any number range in 0.85%, 0.9%, 0.95%, 1%；The mass percent of above-mentioned corrigent Can for 0.01%, 0.03%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, the arbitrary value or any number range in 0.5%；The mass percent of above-mentioned bacteriostatic agent can for 0.01%, 0.03%, appointing in 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5% Meaning value or any number range.
Wherein, above-mentioned bioadhesive gel matrix (also known as gelling agent, bioadhesive material, gel-type vehicle) can be with For the combination of one or more of polyacrylic materials, cellulose material, chitosan, polyvinyl alcohol, sodium alginate；It is above-mentioned Polyacrylic materials are mixed selected from one or more of carbomer, polycarbophil；Above-mentioned cellulose material is selected from hydroxypropyl The mixing of one or more of base cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose.The life Object adhesive gels matrix all has good bioadhesive and film forming as filmogen, can be formed in ulcer surface One layer of isolation film mitigates ulcer pain to shield extraneous physics, chemical factor to the stimulation of ulcerative lesions mucous membrane tissue Bitterly.Bioadhesive gel matrix is the essential ingredient of reparation gel of the invention, formula preparation according to the invention Bioactive minerals material being uniformly distributed in ulcer surface can be guaranteed by repairing gel, thus with a small amount of functional material, that is, low at This acquisition more preferably using effect.If being added without the gel-type vehicle, it is equivalent to " bioactive minerals material " is direct It is added in dispersing agent and medium, bioactive minerals material can sink to bottom, in this way, bioactive minerals material will not It can be effectively adhered to ulcer wound surface, so that cannot play the role of effective.
Above-mentioned bioactive minerals material is selected from one of bioactivity silicon, bioactivity glass, hydroxyapatite Or it is a variety of；Bioactive minerals material plays the role of repair cell as functional material.When the bioactive minerals matter Material is after especially bioactivity silicon is contacted with the surface of a wound, can promote the generation of growth factor and cell absorption, migration and increase It grows, this material is can uniquely to be formed to be chemically bonded with bone tissue, and the material of bonding action can be equally formed with soft tissue.At this In invention amount ranges, the additive amount of " bioactive minerals material " is more, can more promote cell Proliferation, wound repair, But it is more than usage amount range of the present invention, will lead to facilitation reduction.
Above-mentioned dispersing agent be selected from propylene glycol, glycerine, polyethylene glycol (such as Macrogol 4000 or 6000), Tween-80, One or more of dehydrated alcohol mixture.The effect of the dispersing agent is to play pre-dispersed effect, makes bioactive minerals Material is evenly dispersed in ulcer gel, to keep product quality more uniform.
Above-mentioned pH adjusting agent be selected from citric acid, sodium citrate, triethanolamine, dihydric phosphate (particular certain cancers or sylvite), The mixture of one or more of phosphoric acid hydrogen disalt (particular certain cancers or sylvite), lactic acid.The effect of the pH adjusting agent is to make to produce Product keep specific pH value range.
Any one or a few mixture of the above-mentioned corrigent in menthol, borneol, saccharin sodium, eucalyptus oil.It should The effect of corrigent is to mitigate patient pain, improves the mouthfeel of product, and patient is made to be easier to receive.
Above-mentioned bacteriostatic agent is selected from one of methylparaben, ethylparaben, sodium benzoate, potassium sorbate, sodium lactate Or several mixture.The effect of the bacteriostatic agent is to inhibit microorganism growth in product, prevents from extending the shelf life.
Above-mentioned medium dehydrated alcohol and water, in the medium, the percent by volume of dehydrated alcohol are 65%-95%.It is excellent Selection of land, when bioadhesive gel matrix is the matrix for not needing to dissolve by heating, the medium is that percentage by volume is 65%- The ethanol water of 95% (such as: 65%, arbitrary value or any range between the two in 70%, 75%, 80%, 90%, 95%) Solution.When bioadhesive gel matrix is the matrix for needing to dissolve by heating, the medium is the dehydrated alcohol independently used With water.
Ethyl alcohol in the medium can not only play the role of disinfection, and evaporation rate is especially fast, and film formation time is short.Due to The present invention repairs the ethanol solution containing debita spissitudo in gel, so in the case where being added without bacteriostatic agent, shelf-life also phase To long.
Currently, there are no the mouths of addition bioactive minerals material especially bioactivity silicon materials in scientific research and practice Chamber ulcer gel products, simple canker sore gel products are also less, and canker sore product occurs mostly in the form of film, patch； Reparation gel of the invention has just filled up this blank.
Above-mentioned each raw material synergistic effect of the invention, jointly has further reparation gel of the invention and treats well Effect, medium therein, bioadhesive gel matrix have good synergistic effect between bioactive minerals material.
(1) suitable medium is used to cooperate biogel matrix and bioactive minerals material.Above-mentioned reparation is solidifying In glue, bioactive minerals material needs achieve the effect that steadily to be scattered in gel, it is therefore desirable to which gel has certain Consistency；And the gel of the prior art takes water as a solvent more, in contrast, the solvent in the present invention is the aqueous solution of ethyl alcohol, wherein Water is a small part, so needing bioadhesive gel matrix that can not only also be dissolved in water, while to be also dissolved in ethyl alcohol, Said effect can be reached, not so gel consistency is inadequate, and is easy layering, and bioactive minerals material can not be made steady in gel Determine, be evenly distributed.
(2) it uses suitable medium while playing the role of a variety of.Above-mentioned medium (i.e. solvent) be ethyl alcohol aqueous solution or Dehydrated alcohol adds water, has effect: 1) dissolving gel-type vehicle as solvent；2) ethyl alcohol itself has the function of disinfection, can be right Ulcer wound surface carries out sterilizing；3) because ethyl alcohol has the function of disinfection, it can make product that there is the longer shelf-life, even Without adding antibacterial agent；4) evaporation rate of ethyl alcohol is especially fast, therefore after ulcer gel is applied to the surface of a wound, can be fast rapid-result Film will lead to that film formation time is too long, and patient is difficult to receive if using other solvent instead.
(3) bioadhesive gel matrix has a variety of effects.1) after reparation gel is applied to ulcer surface, in bioadhesion Layer protecting film can be formed under the action of property gel-type vehicle, ulcer surface is isolated with oral environment, avoids stimulating, slows down pain Bitterly；2) after reparation gel is applied to the surface of a wound, then the ethyl alcohol elder generation disinfection and sterilization in medium is volatilized, gel-type vehicle film forming, therefore is protected Cuticula and the isolated environment that ulcer surface forms be do not have it is germy, until protective film disappears；3) protective film is by bioactivity mine Material is fixed on around ulcer surface, thus bioactive minerals material can be made to act only on ulcer surface, is concentrated Dosage is repaired；It is all biology rather than as the preparation such as spray used otherwise, in whole oral cavity environment Active mineral material, so bioactive minerals material of the invention is with least additive amount, it is maximum optimal to reach Repairing effect.
(4) although bioactive minerals material itself has good acceleration repairing effect, and do not have adherency and make With bioactive minerals material is just such as when bioactive minerals material being simply applied to ulcer surface, after gargling lower mouth It is washed out, can not be retained for a long time on ulcer surface, do not have the good therapeutic effect to ulcer, it is therefore desirable to Yi Zhongjie Bioactive minerals material is fixed on the surface of a wound by matter within a certain period of time；In this way, ulcer gel of the invention is after film forming, Just play this fixed function.
It can be seen that reparation gel of the invention uses medium, bioadhesive gel matrix, bioactive minerals matter Material is fitted to each other between this three, has synergistic effect, makes to repair gel curative effect and has achieved the effect that 1+1+1 > 3.
As preferred embodiment, above-mentioned bioactive minerals material selects bioactivity silicon, the bioactivity silicon Refer to: the inorganic silicon materials with three-dimensional net structure comprising the silica of 40-70wt%, phosphorus, the calcium of 30-60wt% With the oxide of sodium；Wherein silica forms tridimensional network, and calcium ion and phosphonium ion are orderly distributed in three-dimensional netted silicon Among atom.In present invention bioactivity silicon used in the following embodiment for existing, commercially available, Beijing is happy prebiotic high-new The Regesi of Technology Co., Ltd.'s production regenerates silicon materials (including I type and II type).Above-mentioned bioactivity silicon materials can add Have reparation gel of the invention under conditions of dosage is little to have a better effect.Above-mentioned bioactive minerals material can also be with Bioactivity glass is selected, which can be selected from commercially available 45S5 bioactive glass powder, 58S bioactivity glass At least one of glass powder, 70S bioactive glass powder, 77S bioactive glass powder.
In the present invention, the used in amounts of above-mentioned raw materials will be limited in certain numberical range, otherwise will affect reparation gel The quality of product.(1) for the mass percent of bioadhesive gel matrix if it is less than 0.05%, gel can be partially dilute, causes to hang Buoyancy is bad, partially thick if it is greater than 5%, causes gel-type vehicle that cannot sufficiently dissolve.(2) if the mass percent of dispersing agent Less than 3%, the dissolution time that will lead to gel-type vehicle is elongated, or even influences properties of product, leads to ethyl alcohol if it is greater than 20% The amount of solution is reduced, i.e. gel retrogradation.(3) mass percent of bioactive minerals material cannot if it is less than 0.05% Sufficiently play the role of promote repair, be greater than 5% be easy reunite, and the suspending power of gel be also not achieved can disperse suspension so More bioactive minerals materials.(4) mass percent of pH adjusting agent is if it is less than 0.01% gel peracid, if greatly Alkali is crossed in 1% gel.
As preferred embodiment, above-mentioned its raw material of reparation gel is by mass percentage, comprising:
Further preferably further include:
Corrigent 0.03%-0.4%
Bacteriostatic agent 0.03%-0.4%.
Embodiment more preferably, above-mentioned its raw material of reparation gel is by mass percentage, comprising:
Further preferably further include:
Corrigent 0.05%-0.3%
Bacteriostatic agent 0.05%-0.3%.
Second aspect, the canker sore reparation that the present invention provides the material containing bioactive minerals described in first aspect are solidifying The preparation method of glue.
When not containing corrigent and bacteriostatic agent in the raw material for repairing gel, preparation method includes:
Step 1: solution A is prepared: above-mentioned bioadhesive gel matrix is well-dispersed in the 0.65-0.80 of formula ratio In the above-mentioned dispersing agent of times (such as: arbitrary value or any range between the two in 0.65 times, 0.7 times, 0.75 times, 0.8 times), Then it sufficiently dissolves plus giving an account of matter, obtains solution A.
If selecting the bioadhesive gel of the needs such as polyvinyl alcohol heating, medium water is only added in this step, no Medium dehydrated alcohol is added.
Step 2: miscible: it disperses above-mentioned bioactive minerals material in remaining dispersing agent, it is then molten plus stating Liquid A, and be sufficiently stirred, obtain mixed liquor.
If selecting the bioadhesive gel of the needs such as polyvinyl alcohol heating, need to add in medium in this step Dehydrated alcohol.
Be added pH adjusting agent Step 3: adjusting in pH: Xiang Shangshu mixed liquor, adjustings pH for 3-8 (such as: 3,4,5,6,7,8 Middle arbitrary value or any range between the two).
Step 4: standing defoaming: after the mixed liquor after adjusting pH value is stood defoaming, obtaining above-mentioned reparation gel.
In above step one, two, dispersing agent is divided into two parts addition；In step 1 be added 0.65-0.8 (such as: 0.65 Times, 0.7 times, 0.75 times, arbitrary value or any range between the two in 0.8 times) times formula ratio is used to pre-dispersed gel-type vehicle, Dosage excessively then causes the part of the pre-dispersed bioactive minerals material of dosage in step 2 to tail off, and makes bioactive minerals matter Material cannot be sufficiently pre-dispersed, reunites in gel, and dosage is excessively few then to cause gel-type vehicle sufficiently pre-dispersed, adds medium After cannot quickly dissolve, or even cannot sufficiently dissolve.When containing corrigent or/and bacteriostatic agent in the raw material for repairing gel, system Preparation Method includes:
It weighs step: weighing each raw material according to said ratio, it is spare.
Step 1: solution A is prepared: above-mentioned bioadhesive gel matrix is well-dispersed in 0.7-0.9 times of formula ratio In (such as: arbitrary value or any range between the two in 0.7 times, 0.75 times, 0.8 times, 0.85 times, 0.9 times) dispersing agent, so 0.7-0.9 times (such as: arbitrary value or any range between the two in 0.75 times, 0.8 times, 0.85 times) of formula ratio is added afterwards Medium (herein medium be dehydrated alcohol and water mixed liquor) sufficiently dissolution, obtain solution A.
If selecting the bioadhesive gel of the needs such as polyvinyl alcohol heating, formula ratio described in this step 0.7-0.9 times of medium is replaced by the water in the medium of formula ratio, is added without dehydrated alcohol.
When bioadhesive gel matrix selects the needs such as polyvinyl alcohol to heat the substance that could be dissolved, need above-mentioned Heated in course of dissolution, temperature be 65-95 DEG C (such as: arbitrary value or any in 65 DEG C, 70 DEG C, 75 DEG C, 80 DEG C, 85 DEG C, 90 DEG C Range between the two), preferably 70 DEG C.
Step 2: solution B is prepared: above-mentioned corrigent, bacteriostatic agent being dissolved in remaining medium and (refer to remaining dehydrated alcohol With the mixed liquor of water) in, it is then uniformly mixed with above-mentioned solution A, obtains solution B.If selecting the heating of the needs such as polyvinyl alcohol Bioadhesive gel, then remaining medium refers to the dehydrated alcohol in the medium of formula ratio in this step.
Step 3: miscible: dispersing above-mentioned bioactive minerals material in remaining dispersing agent, then add and state B Solution, and be sufficiently stirred, obtain mixed liquor.In this step, bioactive minerals material is first scattered in dispersing agent, then with it is molten Liquid B mixing, can make bioactive minerals material be well-dispersed in solution B, without reuniting.
Be added pH adjusting agent Step 4: adjusting in pH: Xiang Shangshu mixed liquor, adjustings pH for 3-8 (such as: 3,4,5,6,7,8 Middle arbitrary value or any range between the two).
Step 5: standing defoaming: the mixed liquor after above-mentioned adjusting pH value being stood and is coagulated after defoaming to get canker sore reparation Glue.
In the step of above two preparation method one, gel-type vehicle is first scattered in dispersing agent, and medium dissolution, energy is then added Enough accelerate solution rate, dissolves also more abundant；In the step of above two preparation method three/step 4, pH is finally just adjusted, Because pH is too high or too low, influence whether that the course of dissolution of gel-type vehicle impacts, so this operation is placed on last.
If above two preparation method in the order described above, is not likely to result in (1) bioactive minerals material dough Poly-, (2) gel-type vehicle cannot sufficiently dissolve, to influence the product quality and curative effect of reparation gel.
Embodiment 1:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 2.5%, propylene glycol 8%, bioactivity silicon 1% (Regesi of the commercially available prebiotic new and high technology Co., Ltd production of Beijing happiness regenerates silicon), menthol 0.1%, nipalgin Methyl esters 0.2%, citric acid 0.06%, surplus are that volume fraction is 75% ethanol solution.
Hydroxypropyl cellulose is well-dispersed in first in 0.7 times of formula ratio of propylene glycol, 0.8 times of formula ratio of second is added Alcoholic solution is sufficiently dissolved and is sufficiently swollen, and obtains solution A.Then corrigent menthol, bacteriostatic agent methylparaben are dissolved in residue Ethanol solution in sufficiently dissolve, then be uniformly mixed with above-mentioned solution A, obtain solution B.Bioactivity silicon is well-dispersed in residue Propylene glycol in, the solution B then added is sufficiently stirred.It is eventually adding lemon acid for adjusting pH, and is stirred evenly, it is quiet under room temperature It sets and repairs gel after defoaming to get canker sore.
Embodiment 2:
Raw material is weighed according to following mass percent formula: carbomer 0.2%, propylene glycol 5%, bioactivity silicon 0.5% (Regesi of the commercially available prebiotic new and high technology Co., Ltd production of Beijing happiness regenerates silicon), borneol 0.1%, methylparaben 0.2%, triethanolamine 0.2%, potassium dihydrogen phosphate 0.4%, surplus is 70% ethyl alcohol (volume fraction).
Carbomer is well-dispersed in 0.75 times of propylene glycol of formula ratio first, 0.8 times of formula ratio of ethyl alcohol is added Solution is sufficiently dissolved and is sufficiently swollen, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then It is uniformly mixed with above-mentioned solution A, obtains solution B.Bioactivity silicon is well-dispersed in propylene glycol, after then adding sufficiently swelling B solution, be sufficiently stirred.It is eventually adding triethanolamine, potassium dihydrogen phosphate adjusts pH, and stirs evenly, standing defoaming under room temperature Gel is repaired afterwards to get canker sore.
Embodiment 3:
Weigh raw material according to following mass percent formula: hydroxypropyl methyl cellulose 3%, propylene glycol 10%, biology are living Property silicon 0.1% (Regesi of the prebiotic new and high technology Co., Ltd production of commercially available Beijing happiness regenerates silicon), menthol 0.2%, Sodium benzoate 0.2%, potassium dihydrogen phosphate 0.3%, surplus are 80% ethyl alcohol (volume fraction).
Hydroxypropyl methyl cellulose is well-dispersed in first in 0.8 times of formula ratio of propylene glycol, is added 0.8 times of formula ratio Ethanol solution sufficiently dissolve and be sufficiently swollen, obtain solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution sufficiently Dissolution, then be uniformly mixed with above-mentioned solution A, obtain solution B.Bioactivity silicon is well-dispersed in remaining propylene glycol, then In addition B solution, is sufficiently stirred.Be eventually adding potassium dihydrogen phosphate and adjust pH, and stir evenly, stood under room temperature after defoaming to get Canker sore repairs gel.
Embodiment 4:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 2%, hydroxypropyl methyl cellulose 0.5%, Glycerine 15%, (the Regesi regeneration of the commercially available prebiotic new and high technology Co., Ltd production of Beijing happiness of bioactivity silicon 2% Silicon), borneol 0.2%, methylparaben 0.2%, citric acid 0.06%, potassium dihydrogen phosphate 0.4%, surplus is 80% ethyl alcohol (body Fraction).
Hydroxypropyl cellulose, hydroxypropyl methyl cellulose are well-dispersed in 0.65 times of glycerine of formula ratio first In, 0.8 times of formula ratio of ethanol solution is added and sufficiently dissolves and is sufficiently swollen, obtains solution A.Corrigent, bacteriostatic agent are dissolved in surplus It sufficiently dissolves in remaining ethanol solution, then is uniformly mixed with above-mentioned solution A, obtain solution B.Bioactivity silicon is well-dispersed in surplus In remaining glycerine, B solution is then added, is sufficiently stirred.It is eventually adding potassium dihydrogen phosphate and adjusts pH, and stir evenly, room temperature Gel is repaired after lower standing defoaming to get canker sore.
Embodiment 5:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 1.5%, carbomer 0.1%, glycerine 15%, bioactivity silicon 3% (Regesi of the commercially available prebiotic new and high technology Co., Ltd production of Beijing happiness regenerates silicon), peppermint Brain 0.1%, sodium benzoate 0.2%, triethanolamine 0.1%, citric acid 0.06%, potassium dihydrogen phosphate 0.4%, surplus are 70% second Alcohol (volume fraction).
Hydroxypropyl cellulose, carbomer are well-dispersed in 0.65 times of glycerine of formula ratio first, formula is added 0.8 times of ethanol solution of amount sufficiently dissolves, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining remaining ethanol solution and filled Divide and dissolve and be sufficiently swollen, then be uniformly mixed with above-mentioned solution A, obtains solution B.Bioactivity silicon is well-dispersed in remaining third In triol, B solution is then added, is sufficiently stirred.It is eventually adding triethanolamine, potassium dihydrogen phosphate adjusting pH, and is stirred evenly, often Gel is repaired after the lower standing defoaming of temperature to get canker sore.
Embodiment 6:
Raw material is weighed according to following mass percent formula: hydroxypropyl methyl cellulose 1.5%, carbomer 0.1%, the third three Alcohol 10%, bioactivity silicon 0.5% (Regesi of the commercially available prebiotic new and high technology Co., Ltd production of Beijing happiness regenerates silicon), Borneol 0.1%, methylparaben 0.2%, triethanolamine 0.1%, potassium dihydrogen phosphate 0.4%, surplus are 80% ethyl alcohol (volume point Number).
Hydroxypropyl methyl cellulose, carbomer are well-dispersed in 0.75 times of glycerine of formula ratio first, are added The ethanol solution that 0.8 times of formula ratio is sufficiently dissolved and is sufficiently swollen, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethyl alcohol It sufficiently dissolves in solution, then is uniformly mixed with above-mentioned solution A, obtain solution B.Bioactivity silicon is well-dispersed in remaining the third three In alcohol, above-mentioned solution B is then added, is sufficiently stirred.It is eventually adding potassium dihydrogen phosphate, triethanolamine adjusting pH, and is stirred evenly, It is stood under room temperature and repairs gel after defoaming to get canker sore.
Comparative example 1:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 2.5%, propylene glycol 8%, menthol 0.1%, methylparaben 0.2%, citric acid 0.001%, surplus is that volume fraction is 75% ethanol solution.
Hydroxypropyl cellulose is well-dispersed in propylene glycol first, it is sufficiently molten that 0.8 times of formula ratio of ethanol solution is added It solves and is sufficiently swollen, obtain solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then with above-mentioned solution A is uniformly mixed, and obtains solution B.It is eventually adding lemon acid for adjusting pH, and is stirred evenly, is burst after defoaming is stood under room temperature to get oral cavity Ulcer repairs gel.
Comparative example 2:
Raw material is weighed according to following mass percent formula: carbomer 0.2%, propylene glycol 5%, borneol 0.1%, nipalgin Methyl esters 0.2%, triethanolamine 0.2%, potassium dihydrogen phosphate 0.2%, surplus are 70% ethyl alcohol (volume fraction).
Carbomer is well-dispersed in propylene glycol first, 0.8 times of formula ratio of ethanol solution is added and sufficiently dissolves and fills Divide swelling, obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining remaining ethanol solution and sufficiently dissolved, then with above-mentioned solution A It is uniformly mixed, obtains solution B.It is eventually adding triethanolamine, potassium dihydrogen phosphate adjusts pH, and stirs evenly, standing defoaming under room temperature Gel is repaired afterwards to get canker sore.
Comparative example 3:
Raw material is weighed according to following mass percent formula: hydroxypropyl methyl cellulose 3%, propylene glycol 10%, menthol 0.2%, sodium benzoate 0.2%, potassium dihydrogen phosphate 0.2%, surplus is 80% ethyl alcohol (volume fraction).
Hydroxypropyl methyl cellulose is well-dispersed in propylene glycol first, 0.8 times of formula ratio of ethanol solution is added and fills Divide and dissolve and be sufficiently swollen, obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then with it is above-mentioned Solution A is uniformly mixed, and obtains solution B.It is eventually adding potassium dihydrogen phosphate and adjusts pH, and stir evenly, after standing defoaming under room temperature, i.e., It obtains canker sore and repairs gel.
Comparative example 4:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 2%, hydroxypropyl methyl cellulose 0.5%, Glycerine 15%, borneol 0.2%, methylparaben 0.2%, citric acid 0.001%, potassium dihydrogen phosphate 0.2%, surplus 80% Ethyl alcohol (volume fraction).
Hydroxypropyl cellulose and hydroxypropyl methyl cellulose are well-dispersed in glycerine first, formula ratio 0.8 is added Ethanol solution again is sufficiently dissolved and is sufficiently swollen, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and filled Divide dissolution, then be uniformly mixed with above-mentioned solution A, obtains solution B.It is eventually adding citric acid, potassium dihydrogen phosphate adjusting pH, and is stirred equal It is even, it is stood under room temperature and repairs gel after defoaming to get canker sore.
Comparative example 5:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 1.5%, carbomer 0.1%, glycerine 15%, menthol 0.1%, sodium benzoate 0.2%, triethanolamine 0.1%, citric acid 0.001%, potassium dihydrogen phosphate 0.2% is remaining Amount is 70% ethyl alcohol (volume fraction).
Hydroxypropyl cellulose, carbomer are well-dispersed in glycerine first, 0.8 times of formula ratio of ethanol solution is added Sufficiently dissolution, obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then is mixed with above-mentioned solution A It closes uniformly, obtains solution B.It is eventually adding triethanolamine, citric acid, potassium dihydrogen phosphate to adjust pH, and stir evenly, be stood under room temperature Gel is repaired after defoaming to get canker sore.
Comparative example 6:
Raw material is weighed according to following mass percent formula: hydroxypropyl methyl cellulose 1.5%, carbomer 0.1%, the third three Alcohol 10%, borneol 0.1%, methylparaben 0.2%, triethanolamine 0.1%, potassium dihydrogen phosphate 0.2%, surplus are 80% ethyl alcohol (volume fraction).
Hydroxypropyl methyl cellulose, carbomer are well-dispersed in glycerine first, 0.8 times of formula ratio of ethyl alcohol is added Solution is sufficiently dissolved and is sufficiently swollen, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then It is uniformly mixed with above-mentioned solution A, obtains solution B.It is eventually adding potassium dihydrogen phosphate, triethanolamine adjusts pH, and stirs evenly, room temperature Gel is repaired after lower standing defoaming to get canker sore.
Embodiment 7:
Raw material is weighed according to following mass percent formula: hydroxypropyl cellulose 2.5%, propylene glycol 8%, bioactivity glass Glass (also known as bioactive minerals powder) 1%, menthol 0.1%, methylparaben 0.2%, citric acid 0.1%, surplus are Volume fraction is 75% ethanol solution.
The bioactive minerals powder is by following weight percent at being grouped as: SiO240%, CaO 24%, Na2O 20%, P2O56%, SrO 10%；Wherein, each partial size accounts for the weight percent of bioactive minerals powder are as follows: and partial size 0.01~ 15 μm of powder content is 25%, and the powder content that 15~60 μm of partial size is 65%, and the powder content that 60~150 μm of partial size is 10%.
Hydroxypropyl cellulose is well-dispersed in first in 0.7 times of formula ratio of propylene glycol, 0.8 times of formula ratio of second is added Alcoholic solution sufficiently dissolves, and obtains solution A.Corrigent, bacteriostatic agent are dissolved in remaining ethanol solution and sufficiently dissolved, then with it is above-mentioned molten Liquid A is uniformly mixed, and obtains solution B.Bioactive minerals powder is well-dispersed in remaining propylene glycol, B solution is then added, It is sufficiently stirred.It is eventually adding lemon acid for adjusting pH, and is stirred evenly, is coagulated after defoaming is stood under room temperature to get canker sore reparation Glue.
Embodiment 8
Weigh raw material according to following mass percent formula: (average degree of polymerization 1700, alcoholysis degree are polyvinyl alcohol 1788 88) 4%, Macrogol 4000 5%, (the prebiotic new and high technology Co., Ltd of commercially available Beijing happiness is raw for bioactivity silicon 0.1% The Regesi of production regenerates silicon), disodium hydrogen phosphate 0.3%, eucalyptus oil 0.1%, potassium sorbate 0.2%, surplus is dehydrated alcohol, water (volume ratio of dehydrated alcohol and water is 65/35).
Polyvinyl alcohol is well-dispersed in 0.75 times of Macrogol 4000 of formula ratio first, adds formula ratio Water, heating makes it sufficiently dissolve swelling under the conditions of 70 DEG C, obtains solution A.Corrigent, bacteriostatic agent are dissolved in the anhydrous second of formula ratio It sufficiently dissolves in alcohol, then is uniformly mixed with above-mentioned solution A, obtain solution B.Bioactivity silicon is well-dispersed in remaining poly- second two In alcohol 4000, the B solution then added is sufficiently stirred.It is eventually adding disodium hydrogen phosphate and adjusts pH, and stir evenly, under room temperature It stands and repairs gel after defoaming to get canker sore.
Polyvinyl alcohol is first dissolved in water above and then is mixed again with ethyl alcohol, without being directly added to ethanol solution In, be because heating can make ethyl alcohol rapid evaporation, it is difficult to operate, thus just by medium ethyl alcohol and water dissolve respectively it is different Raw material is to avoid the operation heated to ethyl alcohol.
Detect example:
One, animal experiment:
The foundation and grouping of model: 40 SD mouse, after anesthesia, under the cotton balls calcination mouse tongue for speckling with phenol solution Side 60s is randomly divided into experimental group 1, experimental group 2, experimental group 3, model group to prepare diameter as the ulcer surface of 5mm, and every group each 10 cavys.
Medication: experimental group 1 smears canker sore and repairs gel (embodiment 1), each thickness 2mm, 3 times a day, even It is 5 days continuous.Experimental group 2 smears canker sore and repairs gel (embodiment 7), each thickness 2mm, 3 times a day, continuous 5 days.Experimental group 3, which smear canker sore, repairs gel (comparative example 1), each thickness 2mm, 3 times a day, continuous 5 days.Model group is not dealt with.
Effect assessment: 0 degree: mucous membrane is without ulcer；I degree: ulcer exists, without obvious pseudomembrane at ulcer；II degree: surface at ulcer The pseudomembrane for having one layer of yellow-white thin；III degree: skin surface has thicker pseudomembrane, there is inflammatory edema situation around ulcer；IV degree: Skin surface pseudomembrane is thick, and periulcerous inflammation oedema is serious.
Experimental result after being repaired gel for treating 5 days using canker sore is as shown in table 1, Fig. 1:
Table 1: the treatment effectiveness evaluation statistics after test 5 days
By above-described embodiment 2 and comparative example 2, embodiment 3 and comparative example 3, embodiment 4 and comparative example 4, embodiment 5 with it is right Ratio 5, embodiment 6 and comparative example 6 carry out above-mentioned animal experiment, and the curative effect of each embodiment is better than corresponding comparative example Curative effect.
Two, clinical test:
Patient data: canker sore patient totally 200, male, female each 100, the age 20-65 years old.When this ulcer occurs Between within 48h, and not yet by treatment, patient health status is good.
Exclusion criteria: participating in drug study in 3 months, with immune systems such as other diseases of cari oris mucosa and rheumatoids Disease, there is the disease of diabetic history, diabetes or other influences wound healing, used radiotherapy, chemotherapy in the recent period and was immunized and controls It treats, to this medicine composition allergy, doctor is deemed unsuitable for selected subject etc. according to clinical experience.
Group technology: agreeing to through patient, patient is divided into 2 groups, each 100, control group gives oral cavity ulcer powder treatment (north Capital limited liability company, Tongrentang), treatment group, which is given, prepares canker sore reparation gel for treating in this patent embodiment 1.Through uniting Meter analysis, the patient in experimental group and control group, the age, gender, the course of disease, ulcer area and in terms of without aobvious Sex differernce is write, is comparable.
Treatment method:
Experimental group: patient will be dried first with sanitary cotton swab at ulcer, is then taken in appropriate embodiment 1 and is prepared canker sore Gel is repaired, affected part is applied to, continues the 30s or so that dehisces, gel can form one layer of barrier protection film.3 times a day, continuous 7 It.
Control group: patient will be dried first with sanitary cotton swab at ulcer, then take appropriate oral cavity ulcer powder, be applied to trouble Place, 3 times a day, continuous 7 days.
Judging index:
It is effective: 1-3 days ulcer healings of medication and pain disappearance；
It is effective: 4-5 days ulcer healings of medication and pain disappearance；
Invalid: ulcer does not heal within medication 6 days or more.
Clinical test results:
Remarks: total effective rate is calculated with the sum of effective and effective.

Claims (10)

1. a kind of canker sore of material containing bioactive minerals repairs gel, it is characterised in that: the original for repairing gel Material is by mass percentage, comprising:
2. repairing gel according to claim 1, it is characterised in that: it is described repair gel raw material by mass percentage, Further include:
Corrigent 0.01%-0.5%
Bacteriostatic agent 0.01%-0.5%.
3. repairing gel according to claim 1, it is characterised in that:
The bioadhesive gel matrix is polyacrylic materials, cellulose material, chitosan, polyvinyl alcohol, seaweed The combination of one or more of sour sodium；
Preferably, the polyacrylic materials are selected from the mixture of one or more of carbomer, polycarbophil；The fibre Tie up one of plain class material in hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethylcellulose Kind or several mixtures.
4. repairing gel according to claim 1, it is characterised in that:
The dispersing agent is mixed selected from one or more of propylene glycol, glycerine, polyethylene glycol, Tween-80, dehydrated alcohol Object.
5. repairing gel according to claim 1, it is characterised in that:
The pH adjusting agent in citric acid, sodium citrate, triethanolamine, dihydric phosphate, phosphoric acid hydrogen disalt, lactic acid one Kind or several mixtures；
The dihydric phosphate particular certain cancers or sylvite, the phosphoric acid hydrogen disalt particular certain cancers or sylvite.
6. repairing gel according to claim 2, it is characterised in that:
Any one or a few mixture of the corrigent in menthol, borneol, saccharin sodium, eucalyptus oil；
The antibacterial agent is selected from one of methylparaben, ethylparaben, sodium benzoate, potassium sorbate, sodium lactate or several The mixture of kind.
7. repairing gel according to claim 1, it is characterised in that:
The medium is dehydrated alcohol and water, and in the medium, the percent by volume of dehydrated alcohol is 65%-95%.
8. repairing gel according to claim 1, it is characterised in that: the bioactive minerals material is selected from bioactivity The mixture of one or more of silicon, bioactivity glass, hydroxyapatite；
Preferably, the bioactivity silicon has the inorganic silicon materials of three-dimensional net structure, the titanium dioxide including 40-70wt% Silicon, the oxide of the phosphorus of 30-60wt%, calcium and sodium；Wherein silica forms tridimensional network, and calcium ion and phosphonium ion have Sequence is distributed among three-dimensional netted silicon atom.
Preferably, it is raw to be selected from 45S5 bioactive glass powder, 58S bioactive glass powder, 70S for the bioactivity glass At least one of object activity glass powder, 77S bioactive glass powder.
9. described in any one of claim 1,3-5,7-8 repair gel preparation method, it is characterised in that: this method include with Lower step:
Solution A preparation steps: the bioadhesive gel matrix is well-dispersed in described in 0.65-0.80 times of formula ratio In dispersing agent, the medium is then added and sufficiently dissolves, obtains solution A；
When the bioadhesive gel matrix needs to dissolve by heating, solution A is prepared as follows: by the biological slime Attached property gel-type vehicle is well-dispersed in 0.65-0.80 times of the dispersing agent of formula ratio, and the described of formula ratio is then added Water in medium sufficiently dissolves, and obtains solution A, it is preferable that the temperature heated during the dissolution is 65-95 DEG C, preferably It is 70 DEG C；
Then plus the solution A miscible step: dispersing the bioactive minerals material in remaining dispersing agent,；When When the bioadhesive gel matrix needs to dissolve by heating, it is also necessary to add the anhydrous second in the medium of formula ratio Alcohol；It is sufficiently stirred to obtain mixed liquor later；
It adjusts pH step: pH adjusting agent being added in Xiang Suoshu mixed liquor, adjusting pH is 3-8；
It stands de-foaming steps: after the mixed liquor after adjusting pH value is stood defoaming, obtaining the reparation gel.
10. repairing the preparation method of gel described in claim 1-8, it is characterised in that: method includes the following steps:
Solution A preparation steps: the bioadhesive gel matrix is well-dispersed in described in 0.65-0.80 times of formula ratio In dispersing agent, 0.7-0.9 times of the medium that formula ratio is then added sufficiently dissolves, and obtains solution A；
When the bioadhesive gel matrix needs to dissolve by heating, solution A is prepared as follows: by the biological slime Attached property gel-type vehicle is well-dispersed in 0.65-0.80 times of the dispersing agent of formula ratio, and the described of formula ratio is then added Water in medium sufficiently dissolves, and obtains solution A, it is preferable that the temperature heated during the dissolution is 65-95 DEG C, preferably It is 70 DEG C；
Solution B preparation steps: the corrigent or/and bacteriostatic agent are dissolved in the remaining medium, then with the solution A It is uniformly mixed, obtains solution B；When the bioadhesive gel matrix needs to dissolve by heating, the remaining medium refers to Dehydrated alcohol in the medium of formula ratio；
Miscible step: dispersing the bioactive minerals material in remaining dispersing agent, then plus the B solution, and It is sufficiently stirred, obtains mixed liquor；
It adjusts pH step: pH adjusting agent being added in Xiang Suoshu mixed liquor, adjusting pH is 3-8；
It stands de-foaming steps: after the mixed liquor after adjusting pH value is stood defoaming, obtaining the reparation gel.
CN201910524322.9A 2019-06-17 2019-06-17 A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof Pending CN110169948A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910524322.9A CN110169948A (en) 2019-06-17 2019-06-17 A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910524322.9A CN110169948A (en) 2019-06-17 2019-06-17 A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof

Publications (1)

Publication Number Publication Date
CN110169948A true CN110169948A (en) 2019-08-27

Family

ID=67697433

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910524322.9A Pending CN110169948A (en) 2019-06-17 2019-06-17 A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof

Country Status (1)

Country Link
CN (1) CN110169948A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840295A (en) * 2020-08-18 2020-10-30 隆琰 Insomnia treatment medicine, preparation method and application thereof in treating insomnia
CN113842493A (en) * 2021-09-13 2021-12-28 深圳先进技术研究院 Preparation method of temperature-sensitive hydrogel and temperature-sensitive hydrogel
CN114209604A (en) * 2022-01-12 2022-03-22 北京幸福益生再生医学科技有限公司 Oral care anhydrous composition and preparation method and application thereof
CN115444992A (en) * 2022-05-20 2022-12-09 北京幸福益生再生医学科技有限公司 Absorbable anti-adhesion material and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101347388A (en) * 2008-02-27 2009-01-21 徐阳波 Oral cavity nursing agent and preparation technique thereof
CN104248775A (en) * 2014-09-22 2014-12-31 片仔癀（上海）生物科技研发有限公司 Hydroxyapatite-chitosan compound gel and preparation process and application thereof
CN105709271A (en) * 2016-03-24 2016-06-29 广东泰宝医疗科技股份有限公司 Glass wound repair gel with biological activity and preparation method thereof
CN106362214A (en) * 2016-08-24 2017-02-01 北京幸福益生高新技术有限公司 Regenerated silicon material as well as preparation method and application thereof
CN106890355A (en) * 2017-01-18 2017-06-27 烟台正海生物科技股份有限公司 A kind of bioactivity glass/carboxymethyl chitosan wound repair gel and preparation method thereof
CN107412200A (en) * 2017-04-27 2017-12-01 哈尔滨乾佰纳生物药业有限公司 A kind of spacetabs type stomatocace film with bioadhesive and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101347388A (en) * 2008-02-27 2009-01-21 徐阳波 Oral cavity nursing agent and preparation technique thereof
CN104248775A (en) * 2014-09-22 2014-12-31 片仔癀（上海）生物科技研发有限公司 Hydroxyapatite-chitosan compound gel and preparation process and application thereof
CN105709271A (en) * 2016-03-24 2016-06-29 广东泰宝医疗科技股份有限公司 Glass wound repair gel with biological activity and preparation method thereof
CN106362214A (en) * 2016-08-24 2017-02-01 北京幸福益生高新技术有限公司 Regenerated silicon material as well as preparation method and application thereof
CN106890355A (en) * 2017-01-18 2017-06-27 烟台正海生物科技股份有限公司 A kind of bioactivity glass/carboxymethyl chitosan wound repair gel and preparation method thereof
CN107412200A (en) * 2017-04-27 2017-12-01 哈尔滨乾佰纳生物药业有限公司 A kind of spacetabs type stomatocace film with bioadhesive and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAMADA ELASYED等: "Bioactive Glass-Ceramic Foam Scaffolds from "Inorganic Gel Casting" and Sinter-Crystallization", 《MATERIALS (BASEL)》 *
谢梦生等: "口腔组织再生领域应用中的纳米生物活性玻璃材料", 《中国组织工程研究》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111840295A (en) * 2020-08-18 2020-10-30 隆琰 Insomnia treatment medicine, preparation method and application thereof in treating insomnia
CN113842493A (en) * 2021-09-13 2021-12-28 深圳先进技术研究院 Preparation method of temperature-sensitive hydrogel and temperature-sensitive hydrogel
CN113842493B (en) * 2021-09-13 2022-12-02 深圳先进技术研究院 Preparation method of temperature-sensitive hydrogel and temperature-sensitive hydrogel
CN114209604A (en) * 2022-01-12 2022-03-22 北京幸福益生再生医学科技有限公司 Oral care anhydrous composition and preparation method and application thereof
CN114209604B (en) * 2022-01-12 2024-01-12 北京幸福益生高新技术有限公司 Anhydrous composition for oral care and preparation method and application thereof
CN115444992A (en) * 2022-05-20 2022-12-09 北京幸福益生再生医学科技有限公司 Absorbable anti-adhesion material and preparation method thereof

Similar Documents

Publication Publication Date Title
CN110169948A (en) A kind of canker sore of the material containing bioactive minerals repairs gel and preparation method thereof
CN102600494B (en) Polysaccharide combination and preparation method and application thereof
Hasnain et al. Use of alginates for drug delivery in dentistry
CN103961371B (en) A kind of dental treatment thing with multi-efficiency and compositions thereof
CN105169458A (en) Biological activity mineral substance material and application of biological activity mineral substance material to soft tissue anabrosis and long-time erosion wound cell regeneration and melanoma restraining
CN100457084C (en) Nanometer silver type external use antibiotic gel for female external use and its prepn. method
CN105213298A (en) A kind of oral care gels and preparation method thereof
CN101444555A (en) Purely Chinese traditional medical film for curing oral ulcer and method for preparing same
CN108159024A (en) A kind of sustained release pad pasting for treating canker sore and preparation method thereof
CN105168238A (en) Hyaluronic temperature-sensitive gel and preparation method and application thereof
CN102579286A (en) Traditional Chinese medicine and Western medicine combined strong-efficacy desensitization toothpaste
CN106063798B (en) Oral ulcer treatment patch film and preparation method thereof
CN107596435A (en) A kind of gel of wound repair containing bioactivity glass
CN110917120A (en) Sticky antibacterial repairing material and preparation method and application thereof
CN112023123B (en) Antibacterial gel material for oral restoration and preparation method thereof
CN108079013B (en) Preparation method and application of pain-relieving bioactive glass powder
CN108339122B (en) Preparation method and application of anti-allergy bioactive glass powder
CN1739580A (en) Recipe and prepn process of Chinese medicine gel prepn
CN106581741A (en) Reconstructed human source collagen paste and preparation method thereof
CN112773816B (en) Wound repair spray and preparation method and application thereof
CN101156849B (en) An alepsin slow-releasing gel for promoting paradontal part reborn as well as preparation method and application
CN105343927A (en) Composition for treating dry socket and preparation method of composition
CN108264235A (en) A kind of preparation method and application of the bioactivity glass powder of wound healing
CN103381196A (en) Composition used for treating cervical erosion and application thereof
CN113440434A (en) Pregnant woman toothpaste containing bioactive glass and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20190827