CN104586636A - Tooth-cleaning composition for whitening teeth and repairing wounds - Google Patents
Tooth-cleaning composition for whitening teeth and repairing wounds Download PDFInfo
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- CN104586636A CN104586636A CN201510053889.4A CN201510053889A CN104586636A CN 104586636 A CN104586636 A CN 104586636A CN 201510053889 A CN201510053889 A CN 201510053889A CN 104586636 A CN104586636 A CN 104586636A
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Abstract
The invention discloses a tooth-cleaning composition for whitening teeth and repairing wounds. The tooth-cleaning composition contains urea peroxide and bioactive glass. The tooth-cleaning composition is characterized in that the content of urea peroxide and bioactive glass is less than or equal to 20wt%, and the ratio of urea peroxide to bioactive glass is (0.05-1) to 1. The tooth-cleaning composition can be applied to various whitening tooth-cleaning matters for oral cavities, such as toothpaste, chewing gum, tooth coating powder, tooth strips and whitening gel and is capable of well whitening tooth surface, tooth enamel and dentine, and repairing the tooth enamel and the dentine, and therefore, the wounds are repaired.
Description
[technical field]
The present invention relates to a kind of toothpaste composition, especially a kind of toothpaste composition for dental bleaching and injury repairing.
[background technology]
Tooth is one of human body vitals, has the function of chewing, helping and keeping facial appearance.But along with change of age, chronic dietary and bad life habits all can cause various impact to tooth, one of them the most general result is the variable color of tooth, as tooth is dimmed, turn yellow, blackout waits complexion changed.The most general painted of tooth is that coffee, dark food and smoking cause because the food of excessive more edible easy colorings is as tea.Main manifestations is bacteriogenic pigmentation in external pigment or oral cavity.If take some drugs when tooth development, the excessive absorption of fluoride, or the use of teeth repairing material all can cause painted, as tetracycline pigmentation teeth, and dental fluorosis, enamel hypoplasia etc.
Having a secondary healthy pure white tooth is that people pursue U.S. nature.Tooth whitening becomes the primary demand that modern pursues high-quality life gradually.For most people, bleaching is the simplest beauty therapeutic of one.There is the people up to 1,000,000 to accept dentist's bleaching every year in China, more people may be had to buy commercially available prod and attempt oneself carrying out dental bleaching.
But the bleach that dental bleaching is commonly used is the product containing certain form hydrogen peroxide, and the principle of bleaching utilizes hydrogen peroxide that Organic substance is converted into carbon dioxide and water exactly.Hydrogen peroxide is a kind of oxidant, can produce free radical H2O and O, all has very strong reactivity, when dental bleaching, they can carry out disperse by enamel and Dentinal organic matter, react, reach bleaching effect with the assorted Organic substance be attached on tooth.And the content of hydrogen peroxide is higher, it is shorter to bleach the time used, and effect is better.But enamel is made up of the inorganic salt of 96% and the water of 4% and Organic substance, dentin 70% inorganic salt and 30% water and Organic substance composition.In the process of bleaching dental surface, be also simultaneous to enamel and Dentinal " bleaching ", namely bleach can destroy the Organic substance in enamel and dentin simultaneously, causes injury of teeth.When carrying out vital tooth bleaching, because bleach overflows, most possibly contact is gingiva.Large quantifier elimination shows: the hydrogen peroxide that bleach produces has toxicity to people's gingiva layer fibrocyte.And excessive hydrogen peroxide also can stimulate oral mucosa, throat mucosa, possible swallowing also can stimulate gastric mucosa, causes digestive tract tissue injury.
Bioactivity glass is a kind of biological activity medical material that can be used for human body hard and soft tissue injury repairing.Medical device product containing bioactivity glass is widely used in oral ulcer, burn, the treatment of the aspects such as non-healing wounds, and obtains excellent clinical effectiveness.The toothpaste of bioactivity glass is used to repair tissue of tooth.In toothpaste, bio-vitric can discharge Ca ion and P ion carrys out supplementary dental structure mineral, produce to be deposited on dentinal tubule and within stable crystalloid hydroxyl phosphate ash rock layers, thus reach the object of repairing injury of teeth.
[summary of the invention]
For above-mentioned technical problem, the present invention aims to provide a kind of toothpaste composition for dental bleaching and injury repairing, not only has good whitening effect to tooth surface, enamel and dentin, and can repair oral mucosa, enamel and dentin, play the effect that whitening is repaired.
In order to solve above technical problem, the concrete technical scheme of the present invention is as follows:
A kind of toothpaste composition for dental bleaching and injury repairing, main component is urea peroxide, bioactivity glass and thickening agent, it is characterized in that the content of described urea peroxide and bioactivity glass is not higher than 20wt%, and the ratio of described urea peroxide and bioactivity glass is (0.05-1): 1.
Further, described bioactivity glass each composition weight percentage is as follows:
SiO2:30-80 part;
CaO:10-45 part;
Na2O:0-35 part;
K2O:0-35 part;
P2O5:2-10 part;
MgO:0-10 part;
SrO:0-2 part;
NaF:0-15 part;
B2O3:0-10 part.
Further, the ratio of described urea peroxide and bioactivity glass is (0.05-0.1): 1.
Further, described thickening agent Main Ingredients and Appearance is Polyethylene Glycol and glycerol.
Further, described thickening agent each component weight hundred parts of ratios are as follows:
Glycerol: 62-75 part
Polyethylene Glycol: 24-34 part
Carmomer: 0-5 part;
Silicon dioxide: 0-2 part;
Food coloring: 0-3 part;
Edible sweeting agent: 0-2 part.
A kind of toothpaste composition for dental bleaching and injury repairing provided by the invention, be configured to the whitening teeth thing in various oral cavity as required, as toothpaste, chewing gum, embrocate dentifrice, tooth subsides, bleaching gel etc., it has following beneficial effect:
(1) existing tooth whitening products content of hydrogen peroxide is general all more than 10%, although reach the effect of superficial bleaching to a certain extent, but the Organic substance also destroyed in enamel and dentin, cause injury of teeth, the present invention by select bio-vitric as bioprosthetic material and urea peroxide reasonably combined, wherein urea peroxide content is less than 10%, strengthen urea peroxide bleaching effect, reduce bleach consumption, not only but also can repair the damage of bleach to tooth and oral mucosa while bleaching;
(2) after bioactivity glass hydrolysis, liquid environment is alkalescence, contributes to the whitening effect improving urea peroxide, reduces high concentration urea peroxide to the damage of oral cavity tissue;
(3) overbleaching can cause tissue of tooth to become fragile, and hole increases, and causes enamel to lose, and hydrogen peroxide can stimulate oral mucosa to cause ulcer, and the repair function of bioactivity glass just in time can make up the counter productive of bleaching.
[detailed description of the invention]
Below in conjunction with detailed description of the invention, the present invention is further detailed explanation.
In order to those skilled in the art can understand technical scheme provided by the present invention better, set forth below in conjunction with specific embodiment.
embodiment one:
By urea peroxide and bio-vitric (CaOP2O5K2OSiO2) micropowder in mass ratio (1:50,1:20,1:10,1:1,1:0) add in the anhydrous viscosity carrier of glycerol polyethylene glycol, mix homogeneously makes the colloidal compositions that cleans one's teeth.Wherein urea peroxide and bio-vitric account for 10% of colloidal compositions gross weight, viscosity carrier is 90%.
embodiment two:
Cell toxicity test: adopt the agar diffusion method in YY/T 0127.9, evaluates the cytotoxicity of the different colloidal compositions that cleans one's teeth of allocation ratio, adopts L929 cell strain and grown cultures liquid to be configured to 2.5 × 10
5cell suspension, absorption 10ml adds in culture dish hatches 24h.Then sucking-off culture fluid, adds brand-new agar 10ml, after agar culture medium solidifies, adds neutral red staining liquid and preserves 30min, absorb excess stain liquid.Colloidal compositions and matched group (take culture fluid as negative control group, the filter membrane that phenol solution is soaked is positive controls) are evenly applied on filter membrane, are placed in culture dish.5% carbon dioxide, 37 degrees Celsius of constant temperature lucifuges cultivate 24h.With the region of fading around inverted microscope observation experiment and control material, calculate by table 1 and table 2 in YY/T 0127.9 the index Z that fades respectively and dissolve index L, with reference to the cytotoxicity of the metrics evaluation colloidal compositions of table 3.Its result is as following table.
Colloidal compositions agar diffusion method experimental result
| Experiment material | Cell effect (Z/L value) | Classification | Cytotoxicity explanation | |
| Negative control | 0/0 | 0 | No cytotoxicity | |
| Positive control | 4/4 | 4 | Severe cytotoxicity | |
| Urea peroxide content (0) | 1/1 | 1 | Mild hepatocellular toxicity | |
| Urea peroxide content (1/50) | 1/1 | 1 | Mild hepatocellular toxicity | |
| Urea peroxide content (1/20) | 1/1 | 1 | Mild hepatocellular toxicity | |
| Urea peroxide content (1/10) | 2/2 | 2 | Moderate cytotoxicity | |
| Urea peroxide content (1/0) | 4/4 | 4 | Severe cytotoxicity |
Urea peroxide content is higher, and cytotoxicity is larger.When urea peroxide content is 1/20, be mild hepatocellular toxicity, along with content improves, cytotoxicity is in ascendant trend gradually.When not containing bioactivity glass micropowder, in culture dish, cell is almost all dead, is severe cytotoxicity.
embodiment three:
Irritation on mucous membrane: the oral mucosa irritant test adopting regulation in YY/T 0127.9, does safety evaluatio to the allocation ratio difference colloidal compositions that cleans one's teeth.
Choose the birth cricetulus auratus of 60 ~ 70 days, male same strain.Colloidal compositions sample is according to semisolid material preparation method in standard, and experimental animal is divided into 6 groups at random, often organizes 6.Control material selects the new Gypsum Fibrosum preparata be in harmonious proportion.Stitching contact method is adopted test material cotton piece to be sewn onto the central buccal mucosa surface of hamster side to fitting tightly after Animal Anesthesia.Animal is put to death after clinical observation 24h.Carry out clinical observation and histological score by the content of YY/T 0127.9 table one and table two, carry out pathological reaction classification by table three, its result is as follows:
From each treated animal by pathological reaction classification situation, the extremely light oral mucosa zest of matched group sample.Test group sample is not low containing urea peroxide irritation on mucous membrane, and content increases pathological reaction classification and raises.Not containing bio-vitric is the test group of micropowder, and mucosa irritation is strong, for more than moderate reacting.
embodiment four:
Whitening effect: further whitening effect test is carried out to the allocation ratio difference colloidal compositions that cleans one's teeth.Matched group selects ordinary toothpaste on the market.Be selected into 80 patients suffering from different mottle tooth and carry out random packet use, often organize 20 people.First group uses urea peroxide content (1/50) colloidal compositions to carry out gargling brush, second group uses urea peroxide content (1/20) colloidal compositions, 3rd group uses urea peroxide content (1/10) colloidal compositions, the 4th group of whitening toothpaste using market on sale.Require often to organize everyone and use same volume toothpaste or colloidal compositions to be placed on toothbrush at every turn, rapidly and uniformly the full flank of tooth of brush, and the tooth dyeing part 2 minutes of repeatedly brushing teeth, every day sooner or later each once.The person of participating in the experiment is according to oneself use sense by evaluating whitening effect, and off-test statistical result is as following table:
Use matched group whitening toothpaste to brush teeth, the whitening effect satisfaction rate after two weeks is to 47%, and the satisfaction rate after surrounding is to 57%.
Use urea peroxide content (1/50) colloidal compositions to brush teeth, the whitening effect satisfaction rate after two weeks is to 40%, and the satisfaction rate after surrounding is to 56%.Following up a case by regular visits in process after not finding use has oral cavity uncomfortable, the phenomenon of throat irritation.
Use urea peroxide content (1/20) colloidal compositions to brush teeth, the whitening effect satisfaction rate after two weeks is to 50%, and the satisfaction rate after surrounding is to 75%.Following up a case by regular visits in process after not finding use has oral cavity uncomfortable, the phenomenon of throat irritation.
Use urea peroxide content (1/10) colloidal compositions to brush teeth, the whitening effect satisfaction rate after two weeks is to 72%, and the satisfaction rate after surrounding is to 86%.Following up a case by regular visits in process after not finding use has oral cavity uncomfortable, the phenomenon of throat irritation.
embodiment five:
Bleaching side effect is observed: to the test group using urea peroxide content (1/10) colloidal compositions to brush teeth, and investigate respectively after brushing teeth and occur that tooth is ached, oral cavity is uncomfortable, the phenomenons such as throat irritation.The person of participating in the experiment is according to oneself use sense by carrying out record to whitening side effect, and off-test statistical result is as following table:
Use urea peroxide content (1/10) colloidal compositions to brush teeth, within the observation period of surrounding, all do not occur as tooth is ached, oral cavity is uncomfortable, the whitening side effect such as throat irritation.
Find through many group experiments, when urea peroxide content and bio-vitric content ratio are at (0.05-1): when 1, compositions has good whitening repairing effect, when content ratio is at (0.05-0.1): when 1, compositions has outstanding whitening repairing effect, and does not have whitening side effect.
On the present invention is described in detail, the above, be only the preferred embodiment of the present invention, do not limit the scope of the present invention, namely allly does impartial change according to the application's scope and modify, and all should still belong to covering scope of the present invention.
Claims (5)
1. the toothpaste composition for dental bleaching and injury repairing, this compositions is made up of urea peroxide, bioactivity glass and thickening agent, it is characterized in that the content of described urea peroxide and bioactivity glass is not higher than 20wt%, and the ratio of described urea peroxide and bioactivity glass is (0.05-1): 1.
2. a kind of toothpaste composition for dental bleaching and injury repairing as claimed in claim 1, it is characterized in that, described bioactivity glass each composition weight percentage is as follows:
SiO2:30-80 part;
CaO:10-45 part;
Na2O:0-35 part;
K2O:0-35 part;
P2O5:2-10 part;
MgO:0-10 part;
SrO:0-2 part;
NaF:0-15 part;
B2O3:0-10 part.
3. a kind of toothpaste composition for dental bleaching and injury repairing as claimed in claim 1, it is characterized in that, the ratio of described urea peroxide and bioactivity glass is (0.05-0.1): 1.
4. a kind of toothpaste composition for dental bleaching and injury repairing as claimed in claim 1, it is characterized in that, described thickening agent Main Ingredients and Appearance is Polyethylene Glycol and glycerol.
5. a kind of toothpaste composition for dental bleaching and injury repairing as claimed in claim 4, it is characterized in that, described thickening agent each component weight hundred parts of ratios are as follows:
Glycerol: 62-75 part;
Polyethylene Glycol: 24-34 part;
Carmomer: 0-5 part;
Silicon dioxide: 0-2 part;
Natural pigment: 0-3 part;
Edible sweeting agent: 0-2 part.
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Cited By (5)
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| CN108813084A (en) * | 2018-05-29 | 2018-11-16 | 中国科学院化学研究所 | A kind of chewable composition and preparation method thereof containing phosphosilicate glass |
| CN109422458A (en) * | 2017-08-24 | 2019-03-05 | 徐阳波 | A kind of bioactivity glass and its application method in betel nut product |
| CN110302067A (en) * | 2018-03-20 | 2019-10-08 | 暨南大学 | A kind of adjuvant and preparation method thereof having tooth whitening and repair function |
| CN113749955A (en) * | 2021-09-28 | 2021-12-07 | 中南大学 | Preparation method of tooth gel, tooth paste and tooth gel with remineralization capability |
| CN115463041A (en) * | 2022-09-28 | 2022-12-13 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste with cold light whitening effect and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110302067A (en) * | 2018-03-20 | 2019-10-08 | 暨南大学 | A kind of adjuvant and preparation method thereof having tooth whitening and repair function |
| CN110302067B (en) * | 2018-03-20 | 2022-05-10 | 暨南大学 | Adjuvant with tooth whitening and repairing functions and preparation method thereof |
| CN108813084A (en) * | 2018-05-29 | 2018-11-16 | 中国科学院化学研究所 | A kind of chewable composition and preparation method thereof containing phosphosilicate glass |
| CN113749955A (en) * | 2021-09-28 | 2021-12-07 | 中南大学 | Preparation method of tooth gel, tooth paste and tooth gel with remineralization capability |
| CN115463041A (en) * | 2022-09-28 | 2022-12-13 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste with cold light whitening effect and preparation method thereof |
| CN115463041B (en) * | 2022-09-28 | 2023-10-20 | 重庆登康口腔护理用品股份有限公司 | Anti-sensitivity toothpaste with cold light whitening effect and preparation method thereof |
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