CN111643381A

CN111643381A - Whitening and repairing toothpaste containing bioactive glass and preparation method thereof

Info

Publication number: CN111643381A
Application number: CN202010320005.8A
Authority: CN
Inventors: 姜春鹏; 张明磊
Original assignee: Shanghai Lvrui Biotechnology Co ltd
Current assignee: Shanghai Lvrui Biotechnology Co ltd
Priority date: 2020-04-22
Filing date: 2020-04-22
Publication date: 2020-09-11

Abstract

The application belongs to the technical field of toothpaste, and particularly relates to whitening and repairing toothpaste containing bioactive glass and a preparation method of the whitening and repairing toothpaste. The invention provides whitening and repairing toothpaste containing bioactive glass, which comprises, by weight, 1-15 parts of bioactive glass, 1-10 parts of pyrophosphate, 0.1-5 parts of polyphosphate, 5-30 parts of an abrasive, 0.1-1.5 parts of a thickening agent and 5-15 parts of a dispersing agent. Compared with the traditional fluoride, the bioactive glass material is applied to the toothpaste product to repair the damaged teeth and the decayed tooth disease, and the long-term anti-sensitivity effect is achieved by repairing the exposed dentinal tubules; the whitening and repairing toothpaste disclosed by the invention uses the special type of abrasive hydrated silica, so that the smoothness of teeth can be improved and the teeth can be cleaned while tooth stains on the surfaces of the teeth are effectively cleaned; the pyrophosphate and the polyphosphate are used in the whitening and repairing toothpaste disclosed by the invention, so that exogenous stains on teeth can be effectively eliminated, exogenous stain deposition on teeth can be resisted, and the teeth can be whitened.

Description

Whitening and repairing toothpaste containing bioactive glass and preparation method thereof

Technical Field

The application belongs to the technical field of toothpaste, and particularly relates to whitening and repairing toothpaste containing bioactive glass and a preparation method of the whitening and repairing toothpaste.

Background

Oral health conditions of people in China are not optimistic, caries rate is increased year by year, and problems of gingival bleeding, periodontitis and the like commonly occur. Oral diseases such as dental caries, periodontitis and halitosis are mainly caused by pathogenic bacteria, and the health of human bodies and social interaction are seriously affected. Teeth are capable of withstanding a range of physical and chemical processes in the oral environment. In particular, acid erosion from acidic food or bacterial metabolites leads to demineralization of tooth enamel. Mature enamel, the hardest tissue of the body, is acellular, has a mineral content of over 96%, and does not remodel once demineralized. Therefore, synthetic remineralizing agents are the only viable means of repairing damage.

More than half of the consumers are concerned about yellowing and staining of the teeth, as this is considered a poor indicator of oral hygiene or aging. In addition to the basic needs (plaque removal and caries prevention), consumer demand for oral care products, whitening of tooth surfaces, has a positive effect and continues to grow. Studies have shown that personal dissatisfaction ranges from 17.9 to 52.6% tooth color. This demand for whiter teeth has led to a trend towards increased use of tooth whitening products.

A large number of experiments prove that the fluorine-containing toothpaste can effectively promote remineralization of enamel and resist acid erosion, but the use safety is controversial, like other nutrients, the health effect of fluoride is related to the intake dosage, the proper dosage can maintain the physiological needs of the body, and excessive intake can cause poisoning, and particularly, the fluorine-containing toothpaste is used more cautiously for people in high-fluorine areas or pregnant women. In addition, the swallowing reflex of the children of the low age is not well developed, and the use of the fluorine-containing toothpaste also has certain risk of mistaken swallowing. Clinical trial research has proved that the potassium nitrate toothpaste can effectively relieve tooth sensitivity, and the potassium nitrate can block nerve conduction in dentinal tubules and reduce liquid flow in the dentinal tubules, thereby achieving the anti-sensitivity effect. However, the potassium nitrate cannot repair the tooth damage, and if the potassium nitrate toothpaste is stopped, the sensitive symptoms are still pure, and the tooth sensitive symptoms cannot be effectively solved from the source. The whitening toothpaste taking calcium carbonate as an abrasive has relatively high abrasiveness, and can greatly abrade hard tissues (mainly dentin) of teeth after long-term use, so that the teeth are damaged, and clinical symptoms such as wedge-shaped defects, sensitive teeth and the like are generated.

Disclosure of Invention

In order to solve the technical problems, the first aspect of the invention provides whitening and repairing toothpaste containing bioactive glass, which comprises 1-15 parts of bioactive glass, 1-10 parts of pyrophosphate, 0.1-5 parts of polyphosphate, 5-30 parts of an abrasive, 0.1-1.5 parts of a thickening agent and 5-15 parts of a dispersing agent by weight.

As a preferred technical solution, the bioactive glass has a specific surface area: 90-309m²Per g, pore diameter: 5-7nm, porosity: 0.2-0.4 cc/g.

In a preferred embodiment, the pyrophosphate is tetrasodium pyrophosphate and/or tetrapotassium pyrophosphate.

As a preferable technical scheme, the polyphosphate is pentasodium tripolyphosphate and/or pentapotassium tripolyphosphate.

As a preferable technical scheme, the abrasive is selected from at least one of hydrated silica, calcium hydrogen phosphate, sodium bicarbonate and pearl powder.

As a preferable technical proposal, the hydrated silica is spherical silicon dioxide, and the particle size of the hydrated silica is 10-30 μm.

As a preferable technical scheme, the thickening agent is at least one selected from carbomer, xanthan gum, carrageenan, sodium cellulose, hydroxyethyl cellulose and guar gum.

As a preferred technical scheme, the thickening agent is carbomer and xanthan gum, and the weight ratio of carbomer to xanthan gum is (5-10): 1.

as a preferable technical scheme, the dispersing agent is at least one selected from glycerol, PEG-8, propylene glycol and butanediol.

As a preferable technical scheme, the dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is (0.5-1.5): 1.

as a preferable technical scheme, the toothpaste also comprises 0.1-4 parts by weight of sweetening agent, 0.1-0.5 part by weight of anticaries agent, 1-10 parts by weight of foaming agent, 20-80 parts by weight of glycerin and 0.5-1.5 parts by weight of essence.

As a preferable technical scheme, the anticaries agent is sodium fluoride and/or sodium monofluorophosphate.

As a preferable technical scheme, the foaming agent is selected from at least one of sodium lauryl sulfate, sodium methyl cocoyl taurate and cocamidopropyl betaine.

As a preferred technical scheme, the foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is (1-10): 1.

the second aspect of the invention provides a preparation method of the whitening and repairing toothpaste, which comprises the following steps:

(1) adding a thickening agent into a dispersing agent, dispersing and mixing to obtain a mixture 1 for later use;

(2) heating glycerol to 40-80 deg.C, and stirring;

(3) under the stirring condition, adding the mixture 1 in the step 2, continuously stirring for 0.5-2h under the heating condition, uniformly stirring and mixing, and stopping heating;

(4) adding the sweetening agent, the anticaries agent, the pyrophosphate and the polyphosphate into the step 3 under the stirring condition, and uniformly stirring and mixing;

(5) under the stirring condition, adding the friction agent and the bioactive glass in the step 4, and stirring and mixing uniformly;

(6) and (5) adding the foaming agent and the essence into the mixture obtained in the step (5) under the condition of stirring, and uniformly stirring and mixing the mixture to obtain the foaming agent.

Has the advantages that: compared with the traditional fluoride, the bioactive glass material is applied to the toothpaste product to repair the damaged teeth and the decayed tooth; compared with the traditional desensitizer potassium nitrate, the bioactive glass material is applied to toothpaste products, and the long-term anti-sensitivity effect is achieved by repairing exposed dentinal tubules; the whitening and repairing toothpaste disclosed by the invention uses the special type of abrasive agent hydrated silica, can improve the smoothness of teeth and clean and whiten the teeth while effectively cleaning tooth stains on the surfaces of the teeth, is mild in friction with the teeth and free from damage to enamel compared with the whitening toothpaste taking calcium carbonate as an abrasive material, and is suitable for sensitive teeth patients; the pyrophosphate and the polyphosphate are used in the whitening and repairing toothpaste disclosed by the invention, so that exogenous stains on teeth can be effectively eliminated, exogenous stain deposition on teeth can be resisted, and the teeth can be whitened. Through the synergistic and continuous effects of the effects, the whitening and repairing toothpaste provided by the invention meets the requirements of sensitive tooth patients on tooth whitening effects, improves tooth sensitivity symptoms and repairs damaged teeth.

Drawings

Fig. 1 is a graph of the bacteriostatic effect of the whitening and repairing toothpaste containing bioactive glass prepared in example 3 on streptococcus mutans.

In the figure: the left figure is a control group showing that the whitening and repairing toothpaste containing bioactive glass prepared in example 3 is not added, and the right figure is a test group showing that the whitening and repairing toothpaste containing bioactive glass prepared in example 3 is added.

Fig. 2 is a graph of the bacteriostatic effect of the whitening and repairing toothpaste containing bioactive glass prepared in example 3 on escherichia coli.

Fig. 3 is a graph of the bacteriostatic effect of the whitening and repairing toothpaste containing bioactive glass prepared in example 3 on staphylococcus aureus.

Detailed Description

In order to solve the problems, the invention provides whitening and repairing toothpaste containing bioactive glass, which comprises 1-15 parts of bioactive glass, 1-10 parts of pyrophosphate, 0.1-5 parts of polyphosphate, 5-30 parts of an abrasive, 0.1-1.5 parts of a thickening agent and 5-15 parts of a dispersing agent by weight.

Preferably, the components comprise, by weight, 5-10 parts of bioactive glass, 2-6 parts of pyrophosphate, 0.2-2 parts of polyphosphate, 10-20 parts of a friction agent, 0.5-1.5 parts of a thickening agent and 8-13 parts of a dispersing agent.

Bioactive glass

The bioactive glass mainly comprises SiO₂、Na₂O, CaO and P₂O₅The bioactive glass can promote the mineralization process of the hard tissues of the teeth. Under the environment of body fluid, the bioglass can rapidly react with saliva to form a hydroxyapatite structure similar to that of natural teeth, and the hydroxyapatite structure is deposited on the surfaces of the teeth. The reaction proceeds as follows: 1. na of bioglass species⁺And K⁺Is equal to H in solution⁺、H₃O⁺And (3) rapid exchange: Si-O-Na⁺+H⁺+OH^-→Si-OH⁺+Na⁺+OH^-(ii) a Si-O-Si bonds are broken to form a plurality of Si-OH groups at the interface; Si-OH polymerization to form SiO-rich films on the substrate surface₂And a porous colloidal layer of (1): Si-OH + OH-Si → Si-O-Si + H₂O; 4. ca derived from the matrix or from solution²⁺And PO₄ ^3-In rich SiO₂CaO-P is formed on the colloidal layer in an aggregation way₂O₅An amorphous phase layer. 5. With OH^-And CO₃ ^2-Introducing CaO-P from the solution₂O₅The amorphous phase layer is converted to a polycrystalline body of carbonaceous Hydroxyapatite (HCA).

The alkaline ions released by the bioactive glass can instantly raise the pH value of the solution and increase osmotic pressure to achieve the aim of sterilization, and the bacteria not only comprise common pathogenic bacteria of staphylococcus aureus and escherichia coli, but also comprise oral special aerobic bacteria and anaerobic bacteria, such as streptococcus sanguis, actinobacillus companae and the like.

Preferably, the ratio of the specific surface area of the bioactive glass: 90-309m²Per g, pore diameter: 5-7nm, porosity: 0.2-0.4 cc/g. The testing methods of the specific surface area, the pore diameter and the porosity of the bioactive glass are detection methods commonly used in the field.

In this application, bioactive glass is the whitening type, purchases in shanghai nuo cheng sheng medical science and technology.

Pyrophosphate salt

The pyrophosphate is tetrasodium pyrophosphate and/or tetrapotassium pyrophosphate. The tetrasodium pyrophosphate is also known as anhydrous sodium phosphate.

The pyrophosphate belongs to a calcium phosphate surface active construct, can promote the original membrane protein containing pigment components on the tooth surface to release the adsorption effect, decompose and soften color spots and bring the whitening effect. It can also eliminate magnesium ion and calcium ion deposited on teeth by chelation.

Polyphosphate salt

The polyphosphate is a linear polyphosphate and/or a super phosphate. Preferably, the polyphosphate is pentasodium tripolyphosphate and/or pentapotassium tripolyphosphate. The CAS number of the pentasodium tripolyphosphate is 7758-29-4.

The pentasodium tripolyphosphate has more anions, competes with pigments and proteins for binding sites and is adsorbed to the surface of the hydroxyapatite, so that the attachment of the pigments and the proteins is inhibited, and most of the proteins and coloring matters adsorbed to the surface of the hydroxyapatite are desorbed. Can also chelate calcium ions and can regulate the adsorption and desorption of proteins and coloring substances. Polyphosphate toothpastes provide a more open structure to the acquired film on the dentinal surface, allowing for easy discharge of the colorant.

Friction agent

The abrasive is a solid raw material component which can act together with a toothbrush in the toothpaste to wipe off tartar on the surface of teeth and relieve foreign substances such as tooth stain, dental plaque, dental calculus and the like.

The abrasive is at least one selected from hydrated silica, calcium hydrogen phosphate, sodium bicarbonate and pearl powder. Preferably, the abrasive is hydrated silica.

It has been found that when the particle size of the hydrated silica is 10 to 30 μm, particularly 10 to 20 μm, the prepared toothpaste has a smooth and fine appearance and is comfortable to the oral cavity and the gum when brushing teeth; the particle size is too large, and obvious sand feeling is generated during tooth brushing; the particle size is too fine, and the phenomenon of coarsening can occur.

Preferably, the hydrated silica is purchased from the winning industry group.

Thickening agent

The thickening agent is at least one selected from carbomer, xanthan gum, carrageenan, sodium cellulose, hydroxyethyl cellulose and guar gum.

Preferably, the thickening agent is carbomer and xanthan gum, and the weight ratio of carbomer to xanthan gum is (5-10): 1.

the thickening agent can enable the toothpaste to have proper viscosity and thickness without feeling sticky; the toothpaste has a framework, and the extruded toothpaste can stay on the toothbrush and cannot collapse; the toothpaste is easy to disperse during tooth brushing and has good diffusion performance; and the paste is fine and glossy, the grinding materials are uniformly dispersed, and the paste is not bonded and returns to be coarse.

Dispersing agent

In the application, the dispersion can enable the thickening agent to be uniformly dispersed in a system, and is beneficial to enabling the paste body to quickly build viscosity so as to prevent the thickening agent from agglomerating, reduce the thickening efficiency, ensure the paste forming performance of the paste body in the process production and enable the grinding material to be uniformly dispersed.

The dispersing agent is at least one selected from glycerol, PEG-8, propylene glycol and butanediol.

Preferably, the dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is (0.5-1.5): 1.

as a preferable embodiment, the toothpaste also comprises 0.1 to 4 parts of sweetening agent, 0.1 to 0.5 part of anticaries agent, 1 to 10 parts of foaming agent, 20 to 80 parts of glycerin and 0.5 to 1.5 parts of essence according to parts by weight.

Sweetening agent

Examples of the sweetener include saccharin sodium, xylitol, sucralose, and dipotassium glycyrrhizinate.

Anticariogenic agent

The fluorine compound limits the growth of dental plaque and protects teeth from tooth decay.

The anticariogenic agent is sodium fluoride and/or sodium monofluorophosphate.

Foaming agent

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is (1-10): 1.

the sodium methyl cocoyl taurate (CAS number: 12765-39-8) and cocamidopropyl betaine (CAS number: 61789-40-0) work in concert to promote foaming and ensure that the toothpaste does not leak out of the mouth during brushing.

The second aspect of the present invention provides a method for preparing the toothpaste, comprising the steps of:

(2) heating glycerol to 40-80 deg.C, and stirring;

(6) and (5) adding the essence and the foaming agent into the mixture obtained in the step (5) under the condition of stirring, and uniformly stirring and mixing the mixture to obtain the essence.

The dental caries-preventing toothpaste has the advantages that the components such as bioactive glass, pyrophosphate, polyphosphate, an abrasive, a thickening agent, a dispersing agent, an anticarious agent and a foaming agent are cooperated with one another, so that the health state of an oral cavity is improved, the tooth sensitivity is reduced, the whitening effect of teeth is improved, and the teeth are beautified. A part of the bioactive glass is directly contacted with bacteria such as streptococcus mutans, so that the pH value near the contact surface is increased, and bacterial protein denaturation or osmotic pressure increase at the contact surface causes water loss of the bacteria. The addition of the anticariogenic agent improves the diffusion of bioactive glass in dental plaque, increases the inhibiting effect on enzyme and reduces the formation of pathogenic bacteria in oral cavity. The present application promotes foaming by adding a foaming agent, in particular the foaming agent is sodium methyl cocoyl taurate and/or cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is (1-10): 1, the obtained toothpaste makes the toothpaste become countless fine foams during each tooth brushing, promotes the active components to permeate into the interdental spaces, and cleans black and yellow tartar and bacteria.

The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.

In addition, the starting materials used are all commercially available, unless otherwise specified.

Examples

Example 1

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 1 part of the bioactive glass, 1 part of pyrophosphate, 0.1 part of polyphosphate, 5 parts of an abrasive, 1.5 parts of a thickening agent, 15 parts of a dispersing agent, 0.1 part of an anticaries agent, 10 parts of a foaming agent, 65.1 parts of glycerol, 0.2 part of a sweetening agent and 1 part of essence.

The bioactive glass is purchased from Shanghai Nuo Cheng medical science and technology, and the type number of the bioactive glass is a whitening desensitization type.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The abrasive is hydrated silica, purchased from Yingchuang Industrial group, and has a particle size of 10-30 μm.

The thickening agent is carbomer and xanthan gum, and the weight ratio of the carbomer to the xanthan gum is 5: 1.

The dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is 1.5: 1.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 9: 1.

The preparation method of the whitening and repairing toothpaste comprises the following steps:

(2) heating glycerol to 50 deg.C, and stirring;

(3) adding the mixture 1 in the step 2 under the stirring condition, continuously stirring for 1h under the heating condition, uniformly stirring and mixing, and stopping heating;

Example 2

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 5 parts of the bioactive glass, 2 parts of pyrophosphate, 0.2 part of polyphosphate, 10 parts of an abrasive, 1.1 parts of a thickening agent, 13.2 parts of a dispersing agent, 0.2 part of an anticaries agent, 9 parts of a foaming agent, 58.3 parts of glycerol, 0.2 part of a sweetening agent and 0.8 part of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The thickening agent is carbomer and xanthan gum, and the weight ratio of the carbomer to the xanthan gum is 10: 1.

The dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is 1.2: 1.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 8: 1.

(2) heating glycerol to 50 deg.C, and stirring;

Example 3

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 15 parts of an abrasive, 0.9 part of a thickening agent, 10 parts of a dispersing agent, 0.24 part of an anticaries agent, 7 parts of a foaming agent, 54.26 parts of glycerol, 0.3 part of a sweetening agent and 1 part of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The thickening agent is carbomer and xanthan gum, and the weight ratio of carbomer to xanthan gum is 8: 1.

The dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is 1: 1.

The anticariogenic agent is sodium fluoride.

The sweetener is sucralose.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 5: 2.

(2) heating glycerol to 50 deg.C, and stirring;

Example 4

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 10 parts of the bioactive glass, 6 parts of pyrophosphate, 2 parts of polyphosphate, 20 parts of an abrasive, 0.7 part of a thickening agent, 8.1 parts of a dispersing agent, 0.5 part of an anticaries agent, 8 parts of a foaming agent, 39.2 parts of glycerol, 4 parts of a sweetening agent and 1.5 parts of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The thickening agent is carbomer and xanthan gum, and the weight ratio of the carbomer to the xanthan gum is 6: 1.

The dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is 0.8: 1.

The anticariogenic agent is sodium fluoride.

The sweetener is xylitol.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 7: 1.

The preparation method of the whitening and repairing toothpaste has the specific steps as in example 1.

Example 5

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 15 parts of the bioactive glass, 10 parts of pyrophosphate, 5 parts of polyphosphate, 30 parts of an abrasive, 0.5 part of a thickening agent, 5 parts of a dispersing agent, 0.4 part of an anticaries agent, 7 parts of a foaming agent, 22.7 parts of glycerol, 3.2 parts of a sweetening agent and 1.2 parts of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The thickening agent is carbomer and xanthan gum, and the weight ratio of carbomer to xanthan gum is 9: 1.

The dispersing agent is PEG-8 and propylene glycol, and the weight ratio of the PEG-8 to the propylene glycol is 0.5: 1.

The anticariogenic agent is sodium fluoride.

The sweetening agent is xylitol and dipotassium glycyrrhizinate, and the weight ratio of the xylitol to the dipotassium glycyrrhizinate is 3: 0.2.

the foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 6: 1.

Example 6

The specific implementation mode of the whitening and repairing toothpaste containing the bioactive glass is the same as that of example 4, and the specific implementation mode is different from that of example 4 in that 0.8 part of thickening agent, 56.78 parts of glycerin, 0.32 part of anticaries agent, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 9.9 parts of foaming agent, 0.8 part of essence and 0 part of bioactive glass.

The thickening agent is carbomer and xanthan gum, and the weight ratio of the carbomer to the xanthan gum is 7: 1.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 10: 1.

Example 7

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 0 part of pyrophosphate, 0 part of polyphosphate, 15 parts of an abrasive, 1.0 part of a thickening agent, 10 parts of a dispersing agent, 0.25 part of an anticaries agent, 6 parts of a foaming agent, 59.3 parts of glycerol, 0.25 part of a sweetening agent and 1.2 parts of essence.

The anticariogenic agent is sodium fluoride.

The sweetener is dipotassium glycyrrhizinate.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 2: 1.

Example 8

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 0 part of pyrophosphate, 0 part of polyphosphate, 15 parts of an abrasive, 1.0 part of a thickening agent, 12 parts of a dispersing agent, 0.32 part of an anticaries agent, 8 parts of a foaming agent, 54.93 parts of glycerol, 0.25 part of a sweetening agent and 1.5 parts of essence.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 5: 3.

Example 9

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 0 part of pyrophosphate, 0 part of polyphosphate, 0 part of an abrasive, 1.5 parts of a thickening agent, 13.2 parts of a dispersing agent, 0.43 part of an anticaries agent, 10 parts of a foaming agent, 66.57 parts of glycerol, 0.3 part of a sweetening agent and 1.0 part of essence.

The anticariogenic agent is sodium fluoride.

The sweetening agent is saccharin sodium and sucralose, and the weight ratio of the saccharin sodium to the sucralose is 1: 2.

the foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 1: 1.

Example 10

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 0 part of bioactive glass, 0 part of pyrophosphate, 0 part of polyphosphate, 0 part of an abrasive, 1.5 parts of a thickening agent, 15 parts of a dispersing agent, 0.1 part of an anticaries agent, 1.0 part of a foaming agent, 78.35 parts of glycerol, 3.05 parts of a sweetening agent and 1 part of essence.

The anticariogenic agent is sodium fluoride.

The sweetening agent is xylitol and dipotassium glycyrrhizinate, and the weight ratio of the xylitol to the dipotassium glycyrrhizinate is 3: 0.05.

Example 11

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 15 parts of the bioactive glass, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 15 parts of an abrasive, 0.7 part of a thickening agent, 10 parts of a dispersing agent, 0.24 part of an anticaries agent, 3 parts of a foaming agent, 50.46 parts of glycerol, 0.3 part of a sweetening agent and 1 part of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is sucralose.

Example 12

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 6 parts of pyrophosphate, 2 parts of polyphosphate, 15 parts of an abrasive, 0.9 part of a thickening agent, 10 parts of a dispersing agent, 0.24 part of an anticaries agent, 10 parts of a foaming agent, 43.66 parts of glycerol, 4 parts of a sweetening agent and 1.2 parts of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is xylitol.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 1.5: 1.

Example 13

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 8 parts of the bioactive glass, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 30 parts of an abrasive, 1.1 parts of a thickening agent, 12 parts of a dispersing agent, 0.24 part of an anticaries agent, 2 parts of a foaming agent, 41.26 parts of glycerol, 0.3 part of a sweetening agent and 0.8 part of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is sucralose.

Example 14

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 1 part of the bioactive glass, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 15 parts of an abrasive, 0.9 part of a thickening agent, 8.1 parts of a dispersing agent, 0.42 part of an anticaries agent, 5 parts of a foaming agent, 60.08 parts of glycerol, 4 parts of a sweetening agent and 1.2 parts of essence.

The pyrophosphate is tetrapotassium pyrophosphate.

The polyphosphate is pentapotassium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is xylitol.

Example 15

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 8 parts of the bioactive glass, 1 part of pyrophosphate, 0.1 part of polyphosphate, 15 parts of an abrasive, 0.5 part of a thickening agent, 10 parts of a dispersing agent, 0.5 part of an anticaries agent, 10 parts of a foaming agent, 53.7 parts of glycerol, 0.1 part of a sweetening agent and 1.1 parts of essence.

The pyrophosphate is tetrapotassium pyrophosphate.

The polyphosphate is pentapotassium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

Example 16

The whitening and repairing toothpaste containing the bioactive glass comprises, by weight, 7 parts of the bioactive glass, 4 parts of pyrophosphate, 0.3 part of polyphosphate, 5 parts of an abrasive, 0.7 part of a thickening agent, 7 parts of a dispersing agent, 0.36 part of an anticaries agent, 10 parts of a foaming agent, 64.74 parts of glycerol, 0.3 part of a sweetening agent and 0.6 part of essence.

The pyrophosphate is tetrasodium pyrophosphate.

The polyphosphate is pentasodium tripolyphosphate.

The anticariogenic agent is sodium fluoride.

The sweetener is sucralose.

The foaming agent is sodium methyl cocoyl taurate and cocamidopropyl betaine, and the weight ratio of the sodium methyl cocoyl taurate to the cocamidopropyl betaine is 7: 3.

Performance testing

1. Safety performance test of whitening and repairing toothpaste

The test is carried out according to the GB/T35832-2018 detection method.

The test results are shown in Table 1.

TABLE 1 results of friction value test for examples 1 to 16

Examples	Ra value
		Example 1	0.255
Example 2	0.453
		Example 3	0.904
Example 4	1.583
		Example 5	1.992
Example 6	0.678
		Example 7	0.829
Example 8	0.774
		Example 9	0.164
Example 10	0.101
		Example 11	0.894
Example 12	0.992
		Example 13	1.923
Example 14	0.825
		Example 15	0.753
Example 16	0.495

2. Whitening performance test of whitening and repairing toothpaste

The test method comprises the following steps: taking a bovine enamel block, and carrying out embedding, polishing, cleaning and acid etching treatment to simulate the tooth surface which is possibly damaged to a certain extent in daily life. And (3) putting the acid-etched tooth enamel block into a dyeing solution for dyeing, wherein the dyeing solution is a mixed solution of black tea, gastric mucin, FeCl3 and water with a certain concentration, continuously dyeing for 5 days at a constant temperature of 37 ℃, and finally smoking for 30 minutes by using tobacco. The stained enamel blocks were numbered and labeled, the enamel color was measured using a color difference meter to obtain L1, and enamel blocks with L1 values of 35-45 were selected and randomly assigned to example groups of 10 blocks each.

Fixing the enamel block on an L8-II cross tooth brushing machine, simulating tooth brushing for 8000 times, taking out the enamel sample from the tooth brushing machine, washing with water, and air drying. The color of enamel after brushing was measured to give L2. And calculating the change value delta L of the enamel color before and after tooth brushing so as to evaluate the whitening effect of removing the extrinsic stains of the teeth of each group of toothpaste samples. The larger the Δ L value, the higher the whitening degree, and the better the whitening effect.

△L＝[(L2-L1)/L1]×100％

The results of Δ L calculation are shown in Table 2.

Table 2 examples 1-16 whitening performance test results

3. Whitening and repairing toothpaste antibacterial performance test

With reference to QB/T2738-. The toothpastes of example 2 and examples 4-9 show different reductions in bacterial inhibition, specifically, taking streptococcus mutans as an example, the average inhibition is preferably greater than 95%, good when greater than 85% and less than 95%, medium when greater than 75% and less than 85%, and poor when less than 75%, and the results are shown in table 3.

Table 3 results of the bacteriostatic ability tests of examples 1 to 16

4. Efficacy test of whitening and repairing toothpaste

And (3) evaluating the efficacy: test subjects: subject 160, with 80 people in tooth sensitivity and tooth pain, 40 people in stain group, 40 people in breath group, and male and female halves. The subjects were randomly divided into 16 groups of 10 persons, brushed twice a day for 2min each time with the toothpastes prepared in examples 1 to 16, respectively, and tested after one month, and subjected to sensory evaluation according to the effect of use. The scoring criteria were as follows: the score was 10, the score 0 was the worst and the score 10 was the best, and the results are shown in Table 4.

Table 4 examples 1-16 efficacy test results

As can be seen from tables 2 and 3, examples 3, 4, 5, 11, 12 and 13 have better whitening effect and bacteriostatic effect, but table 1 shows that examples 4, 5 and 13 have too high friction value and damage teeth after long-term use, and table 4 shows that examples 4, 5 and 13 are inferior to examples 3, 11 and 12 in improving tooth sensitivity and tooth pain; as is clear from table 2, examples 3, 11 and 12 have a good whitening effect without a large change in Δ L value, but from the viewpoint of cost and the like, example 3 is preferred and example 3 is the most preferred embodiment.

The toothpaste disclosed by the invention is compounded with the relevant standards of the national standard GB8372-2008 toothpaste of the people's republic of China.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content disclosed above into an equivalent embodiment with equivalent changes, but all those simple modifications, equivalent changes and modifications made on the above embodiment according to the technical spirit of the present invention still belong to the protection scope of the present invention.

Claims

1. The whitening and repairing toothpaste containing bioactive glass is characterized by comprising, by weight, 1-15 parts of bioactive glass, 1-10 parts of pyrophosphate, 0.1-5 parts of polyphosphate, 5-30 parts of an abrasive, 0.1-1.5 parts of a thickening agent and 5-15 parts of a dispersing agent.

2. The multi-effect toothpaste of claim 1 wherein the bioactive glass has a specific surface area of: 90-309m²Per g, pore diameter: 5-7nm, porosity: 0.2-0.4 cc/g.

3. The whitening and repairing toothpaste according to claim 1, wherein the pyrophosphate is tetrasodium pyrophosphate and/or tetrapotassium pyrophosphate.

4. The whitening and healing toothpaste of claim 1, wherein the polyphosphate is pentasodium tripolyphosphate and/or pentapotassium tripolyphosphate.

5. The whitening and repairing toothpaste according to claim 1, wherein the abrasive is at least one selected from the group consisting of hydrated silica, calcium hydrogen phosphate, sodium bicarbonate and pearl powder, and as a preferred embodiment, the hydrated silica is spherical silicon dioxide having a particle size of 10 to 30 μm.

6. The whitening and repairing toothpaste according to claim 1, wherein the thickener is at least one selected from carbomer, xanthan gum, carrageenan, sodium cellulose, hydroxyethyl cellulose and guar gum, and as a preferred technical scheme, the thickener is carbomer and xanthan gum, and the weight ratio of carbomer to xanthan gum is (5-10): 1.

7. the whitening and repairing toothpaste as claimed in claim 1, wherein the dispersant is at least one selected from the group consisting of glycerin, PEG-8, propylene glycol and butylene glycol, and as a preferred embodiment, the dispersant is PEG-8 and propylene glycol, and the weight ratio of PEG-8 to propylene glycol is (0.5-1.5): 1.

8. the whitening and repairing toothpaste according to any one of claims 1 to 7, wherein the toothpaste further comprises 0.1 to 4 parts by weight of a sweetener, 0.1 to 0.5 part by weight of an anticaries agent, 1 to 10 parts by weight of a foaming agent, 20 to 80 parts by weight of glycerin, and 0.5 to 1.5 parts by weight of an essence.

9. The whitening and repairing toothpaste according to claim 8, wherein the anticaries agent is sodium fluoride and/or sodium monofluorophosphate; as a preferred technical scheme, the anticaries agent is sodium fluoride.

10. A method for preparing the whitening and repairing toothpaste according to any one of claims 8 to 9, which comprises the following steps:

(2) heating glycerol to 40-80 deg.C, and stirring;