CN113244121B - Whitening and antibacterial toothpaste - Google Patents
Whitening and antibacterial toothpaste Download PDFInfo
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- CN113244121B CN113244121B CN202110742783.0A CN202110742783A CN113244121B CN 113244121 B CN113244121 B CN 113244121B CN 202110742783 A CN202110742783 A CN 202110742783A CN 113244121 B CN113244121 B CN 113244121B
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 28
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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Abstract
The invention discloses whitening and antibacterial toothpaste which comprises the following raw materials: hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, whitening compound, hydrated silica, sorbitol, carrageenan, cocamidopropyl betaine, mint essence, phenoxyethanol and water. The whitening and antibacterial toothpaste has good stain removing, whitening and antibacterial capabilities.
Description
Technical Field
The invention belongs to the technical field of toothpaste, and particularly relates to whitening and antibacterial toothpaste.
Background
A large amount of microorganisms exist in the oral cavity of a human body, and if residual food in the oral cavity is not cleaned in time, harmful bacteria can be rapidly propagated, so that oral infection and enamel damage can be caused, and teeth can be discolored and yellowed to influence the appearance. Residual food and harmful bacteria in the oral cavity can be effectively removed through regular tooth brushing, and the health and the hygiene of the oral cavity are maintained. The toothpaste is used as a tooth cleaning product, and can effectively clean teeth and purify the oral cavity. Chinese patent CN107184421A discloses a high-efficiency whitening and mothproof toothpaste and a preparation method thereof, which comprises an abrasive, a wetting agent, a bonding agent, a foaming agent, a diluent, calcium glycerophosphate, sodium monofluorophosphate, sodium fluoride, sodium phytate and sodium pyrophosphate, and has the effects of moth-proofing repair, stain removal and whitening, but the problems of how to inhibit harmful bacteria in the oral cavity and how to resist allergy are not solved.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides whitening and antibacterial toothpaste.
In order to solve the technical problems, the invention adopts the technical scheme that:
the whitening and antibacterial toothpaste comprises the following raw materials: hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, hydrated silica, sorbitol, carrageenan, cocamidopropyl betaine, mint essence, phenoxyethanol and water.
Preferably, the whitening and antibacterial toothpaste comprises the following raw materials: hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, whitening compound, hydrated silica, sorbitol, carrageenan, cocamidopropyl betaine, mint essence, phenoxyethanol and water.
Preferably, the whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight: 0.3-0.6 part of hyaluronic acid, 1-3 parts of medical stone, 0.5-2 parts of natural tea tree oil, 0.1-0.5 part of vitamin C, 2-5 parts of desensitizer, 3-5 parts of whitening compound, 35-45 parts of hydrated silica, 10-20 parts of sorbitol, 0.5-2 parts of carrageenan, 1.5-3 parts of cocamidopropyl betaine, 0.1-0.5 part of mint essence, 0.1-0.5 part of phenoxyethanol and 35-50 parts of water.
The whitening compound is prepared by the following method:
cleaning caulis Trachelospermi leaves, air drying, and pulverizing to 50-80 mesh to obtain caulis Trachelospermi leaf powder; adding 5-8 parts by weight of Chinese starjasmine stem leaf powder into 40-50 parts by weight of extraction solvent, and performing ultrasonic treatment for 0.5-1h under the ultrasonic conditions of 300-500W and 20-30kHz, wherein the extraction solvent is 30-50wt% of glycerol aqueous solution; adding 0.5-1 weight part of malic acid and 0.5-0.8 weight part of sodium citrate, mixing, and microwave extracting at 80-90 deg.C under 350-500W for 1-3 hr; filtering, concentrating the filtrate to 25-35% of the original weight, adding 3-5 parts by weight of perlite, mixing uniformly, and performing ball milling treatment for 0.5-1h, wherein the ball-material ratio is 10 (1-3), and the ball milling rotation speed is 800-1000rpm; spray drying to obtain the final product.
The desensitizer is any one of desensitizing composition and desensitizing salt bead.
The desensitizing composition is prepared by the following method: mixing sodium alginate 1-2 weight parts, dextranase 1.5-3 weight parts, and strontium acetate 0.5-1.2 weight parts.
Periodontal disease is mainly due to the presence of a number of pathogenic bacteria in the oral cavity, of which caries caused by streptococcus mutans is one of the major causes of tooth sensitivity. Whereas dental plaque and biofilm in the oral cavity are primarily composed of dextran, a product of the cariogenic pathogen, streptococcus mutans. Dextranase is a hydrolase which specifically catalyzes alpha-1, 6 glucosidic bonds in dextran molecules, can inhibit the adhesion of streptococcus mutans on teeth, and reduces a biofilm formed after the adhesion of water-soluble dextran, thereby preventing dental caries; meanwhile, the water-soluble dextran in the matrix can be reduced to reduce the formation and accumulation of the streptococcus mutans biofilm. However, the stability of dextranase in oral care products is susceptible to a number of factors, such as temperature, acid, base, and other ingredients such as surfactants, resulting in reduced enzyme activity.
Therefore, the invention adopts the gelation reaction between uronic acid in sodium alginate and calcium ions to form rigid gel to encapsulate dextranase, so as to solve the problem of compatibility between dextranase and other components in toothpaste, improve the stability of toothpaste, ensure the enzyme activity of dextranase in toothpaste, and improve desensitization effect.
Preferably, the desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1-2 parts by weight of sodium alginate, 1.5-3 parts by weight of dextranase and 0.5-1.2 parts by weight of strontium acetate in 75-85 parts by weight of water to obtain a solution a; dissolving 0.5-1.5 parts by weight of calcium chloride in 50-150 parts by weight of water to obtain a solution c;
s2, stirring the solution a at the rotating speed of 1000-1500rpm for 10-20min, then adding 0.1-0.3 part by weight of cross-linking agent, continuously stirring, adding the solution c after 3-8min, continuously stirring for 30-60min, filtering out small balls, washing with water for three times, and drying at 45-60 ℃ for 6-10h to obtain desensitized salt beads.
Further, the desensitizing salt bead is prepared by the following method:
s1, dissolving 1-2 parts by weight of sodium alginate, 1.5-3 parts by weight of dextranase and 0.5-1.2 parts by weight of strontium acetate in 75-85 parts by weight of water to obtain a solution a; dispersing 0.5-1.5 parts by weight of potato starch in 15-25 parts by weight of water to obtain a dispersion liquid b; dissolving 0.5-1.5 parts by weight of calcium chloride in 50-150 parts by weight of water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1000-1500rpm for 10-20min, then adding 0.1-0.3 part by weight of a cross-linking agent, continuing to stir, adding the solution c after 3-8min, continuing to stir for 30-60min, filtering out small balls, washing with water for three times, and drying at 45-60 ℃ for 6-10h to obtain the desensitized salt beads.
According to the invention, potato starch is used in the preparation process of the desensitized salt beads, and a large number of hydroxyl groups on starch molecules can interact with carboxyl groups of sodium alginate through intermolecular hydrogen bonds to play a role in tackifying in a reaction system, so that a complex matrix network is formed, and the dextran enzyme is prevented from leaking from the desensitized salt beads.
Further, the desensitizing salt beads are prepared by the following method:
s1, dissolving 1-2 parts by weight of sodium alginate, 1.5-3 parts by weight of dextranase and 0.5-1.2 parts by weight of strontium acetate in 75-85 parts by weight of water to obtain a solution a; dispersing 0.5-1.5 weight parts of potato starch in 15-25 weight parts of water, stirring in 68-78 deg.C water bath at 800-1200rpm for 15-30min, taking out, and cooling to room temperature to obtain dispersion liquid b; dissolving 0.5-1.5 parts by weight of calcium chloride in 50-150 parts by weight of water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1000-1500rpm for 10-20min, then adding 0.1-0.3 part by weight of a cross-linking agent, continuing to stir, adding the solution c after 3-8min, continuing to stir for 30-60min, filtering out small balls, washing with water for three times, and drying at 45-60 ℃ for 6-10h to obtain the desensitized salt beads.
The inventor further finds that the water absorption of the desensitizing salt beads is reduced after the insoluble potato starch particles in the desensitizing salt beads are reacted with sodium alginate; but after the potato starch is gelatinized, the water absorption performance is improved, and after the potato starch is contacted with water during tooth brushing, the gelatinized potato starch can be dissolved from the surface of the desensitizing salt bead to play a role of a pore-forming agent, so that the release of dextranase from the desensitizing salt bead is accelerated when the toothpaste is used, and the improvement of desensitizing effect is facilitated.
The cross-linking agent is one or more of glutaraldehyde, epichlorohydrin, sodium tripolyphosphate, glycol glycidyl ether and adipic acid.
Preferably, the crosslinking agent is a mixture of sodium tripolyphosphate and adipic acid, wherein the mass ratio of the sodium tripolyphosphate to the adipic acid is (1-3) to (2-5).
According to the desensitizing salt bead, sodium tripolyphosphate and adipic acid are compounded to serve as a cross-linking agent, so that the cross-linking effect can be improved, the mechanical strength of the desensitizing salt bead is enhanced, the enzyme activity can be maintained to a greater extent, and the stability of the desensitizing salt bead is further improved.
The invention also provides a preparation method of the whitening antibacterial toothpaste, which comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, a desensitizer, a whitening compound, hydrated silica and phenoxyethanol into water according to the parts by weight, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 1-3min at the stirring speed of 160-200rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 20-30min at the stirring speed of 30-60rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 8-12min at the stirring speed of 30-60rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree between-0.1 and-0.09 MPa, stirring for 10-15min at the speed of 30-60rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) Pouring out the paste from the vacuum paste making machine, filling into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
The invention has the beneficial effects that: the whitening and antibacterial toothpaste has good stain removing, whitening and antibacterial capabilities. Desensitizing salt beads are used as desensitizing agents, wherein the desensitizing salt beads contain dextranase, strontium nitrate and other components, starch is added, on one hand, the desensitizing salt beads play a role in tackifying and preventing enzymes from losing from the desensitizing salt beads, and on the other hand, the gelatinized starch also plays a role in a pore-forming agent, so that the release of the enzymes can be accelerated when the toothpaste is used, and the desensitizing effect is improved.
Detailed Description
The above summary of the present invention is described in further detail below with reference to specific embodiments, but it should not be understood that the scope of the above subject matter of the present invention is limited to the following examples.
Introduction of some raw materials in this application:
hyaluronic acid, CAS No.: 9004-61-9, islands Wanyuan Biotech Ltd.
A plurality of studies at home and abroad show that hyaluronic acid also HAs strong physiological activity in the oral cavity field, and hyaluronic acid HAs the functions of resisting inflammation and infection and promoting the repair and reconstruction of periodontal tissues and wound healing, for example, after chronic periodontitis patients are subjected to mechanical treatment or periodontal surgery, HA gel is locally added to prevent the destruction of the periodontal tissues, relieve the inflammation of gingiva and promote the recovery of the periodontal tissues.
Medical stone, particle size: 100 mesh, hebei Jianshi New materials science and technology Co., ltd.
Maifanitum contains more than 20 essential elements such as zinc, iron, and magnesium, wherein zinc is a component of some enzymes, participates in metabolism and synthesis of DNA, RNA and protein, and is one of essential elements for promoting wound and wound healing. Is beneficial to healing periodontal tissues, eliminating ulcer on the inner wall of periodontal pocket, relieving swelling and pain of gingival tissues, improving gingival bleeding, and improving slight periodontitis symptom. The medical stone and the hyaluronic acid are synergistic, so that the growth and recovery of gum are promoted, gum bleeding is reduced, the exposure of enamel is reduced, the enamel is protected, and the tooth sensitivity resistance is enhanced.
Natural tea tree oil, CAS No.: 68647-73-4% of p-menthene-1-ol (greater than or equal to 30%), jiangxixinsen Natural vegetable oil Co.
Tea tree oil contains various functional components such as tea polyphenol, alkaloid, saccharides, amino acid, tea pigment, saponin, fluorine, vitamins and the like, and also has wide antibacterial, bactericidal and bacteriostatic effects. The tea tree oil and the hyaluronic acid have stronger sterilization effect in a synergistic manner, and meanwhile, the activity of damaged gingival peripheral cells can be improved, and gum repair is promoted. In addition, various fluorine, phenol and ester substances in the tea tree oil can be soaked into the enamel to enhance the acid resistance of the enamel, and fluoride can also react with hydroxyapatite which is a main component of the enamel to form harder fluorapatite, so that the abrasion of the enamel is reduced, and the enamel is protected.
Vitamin C, CAS No.: 50-81-7, shanghai regular Bignonia industry development Co., ltd.
The addition of vitamin C is beneficial to improving gingival bleeding symptoms and preventing alveolar bone destruction and atrophy.
Hydrated silica, CAS number: 7631-86-9, granularity: 325 mesh, goods number: CG3694, new material science and technology limited, chenguang, hannan.
Peppermint essence, shanxi morning bright biotechnology limited.
Phenoxyethanol, CAS No.: 122-99-6, shanghai-derived leaf Biotech, inc.
Sorbitol, CAS No.: 50-70-4, shenzhen Shaanqiang Biotechnology Limited.
Carrageenan, CAS No.: 11114-20-8, shandong Fengtai Biotech Co., ltd.
Cocamidopropyl betaine, CAS No.: 86438-79-1, eplon Biotech, inc. of Tianjin.
Dextranase, also known as alpha-1, 6 glucanase, enzyme activity: 30000U/g, zhongnuo Biotechnology development Jiangsu Co., ltd.
The potato starch is commercially available food-grade potato starch, and has the following water content: 19.2% by weight of vastly condiments Limited in Qingzhou city.
Example 1
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is a desensitizing composition.
The desensitizing composition is prepared by the following method: mixing 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, hydrated silica and phenoxyethanol into water according to the weight parts, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the weight parts, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) Pouring out the paste from the vacuum paste making machine, filling into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 2
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, stirring the solution a at the rotation speed of 1200rpm for 15min, then adding 0.15 part by weight of sodium tripolyphosphate, continuously stirring, adding the solution c after 5min, continuously stirring for 40min, filtering out small balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain desensitized salt beads.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, a desensitizer, hydrated silica and phenoxyethanol into water according to the parts by weight, mixing and dispersing, then adding the mixture into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) Pouring out the paste from the vacuum paste making machine, filling into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 3
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1200rpm for 15min, then adding 0.15 part by weight of sodium tripolyphosphate, continuously stirring, adding the solution c after 5min, continuously stirring for 40min, filtering out small balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain the desensitized salt beads.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, hydrated silica and phenoxyethanol into water according to the weight parts, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 4
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water, then placing the mixture in a water bath at 70 ℃ and stirring the mixture for 20min at the rotating speed of 1000rpm, taking out the mixture and cooling the mixture to room temperature to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1200rpm for 15min, then adding 0.15 part by weight of sodium tripolyphosphate, continuously stirring, adding the solution c after 5min, continuously stirring for 40min, filtering out small balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain the desensitized salt beads.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, a desensitizer, hydrated silica and phenoxyethanol into water according to the parts by weight, mixing and dispersing, then adding the mixture into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of a paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 5
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water, then placing the mixture in a water bath at 70 ℃ and stirring the mixture for 20min at the rotating speed of 1000rpm, taking out the mixture and cooling the mixture to room temperature to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1200rpm for 15min, then adding 0.15 part by weight of adipic acid, continuing stirring, adding the solution c after 5min, continuing stirring for 40min, filtering out small balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain the desensitized salt beads.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, hydrated silica and phenoxyethanol into water according to the weight parts, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of a paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 6
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The desensitizing agent is desensitizing salt beads.
The desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water, then placing the mixture in a water bath at 70 ℃ and stirring the mixture for 20min at the rotating speed of 1000rpm, taking out the mixture and cooling the mixture to room temperature to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotation speed of 1200rpm for 15min, then adding 0.15 part by weight of cross-linking agent, continuing to stir, adding the solution c after 5min, continuing to stir for 40min, filtering out balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain desensitizing salt beads.
The cross-linking agent is a mixture of sodium tripolyphosphate and adipic acid, wherein the mass ratio of the sodium tripolyphosphate to the adipic acid is 2.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, hydrated silica and phenoxyethanol into water according to the weight parts, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
Example 7
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 5 parts by weight of whitening compound, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The whitening compound is prepared by the following method:
cleaning, airing and crushing picked fresh Chinese starjasmine stem leaves to 80 meshes to obtain Chinese starjasmine stem leaf powder; adding 8 parts by weight of Chinese starjasmine stem leaf powder into 50 parts by weight of extraction solvent, and carrying out ultrasonic treatment for 0.5h under the ultrasonic conditions of 500W and 30kHz, wherein the extraction solvent is 35wt% of glycerol aqueous solution; then adding 0.8 weight part of malic acid and 0.6 weight part of sodium citrate, mixing uniformly, and performing microwave extraction at 85 ℃ and 500W for 1.5h; filtering, concentrating the filtrate to 35% of the original weight, adding 3.5 parts by weight of perlite, uniformly mixing, and performing ball milling treatment for 0.5h, wherein the ball-material ratio is 10; spray drying to obtain the final product.
The desensitizing agent is desensitizing salt beads; the desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water, then placing the mixture in a water bath at 70 ℃ and stirring the mixture for 20min at the rotating speed of 1000rpm, taking out the mixture and cooling the mixture to room temperature to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotation speed of 1200rpm for 15min, then adding 0.15 part by weight of cross-linking agent, continuing to stir, adding the solution c after 5min, continuing to stir for 40min, filtering out balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain desensitizing salt beads.
The cross-linking agent is a mixture of sodium tripolyphosphate and adipic acid, wherein the mass ratio of the sodium tripolyphosphate to the adipic acid is 2.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, desensitizer, whitening compound, hydrated silica and phenoxyethanol into water according to the weight parts, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the weight parts, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste. Wherein CAULIS Trachelospermi leaf is CAULIS Trachelospermi (Trachelospermi CAULIS ET FOLIUM); the particle size of the perlite is 200 meshes.
Example 8
The whitening and antibacterial toothpaste is prepared from the following raw materials in parts by weight:
0.5 part by weight of hyaluronic acid, 2 parts by weight of medical stone, 1.5 parts by weight of natural tea tree oil, 0.3 part by weight of vitamin C, 4 parts by weight of desensitizer, 5 parts by weight of whitening compound, 42 parts by weight of hydrated silica, 17 parts by weight of sorbitol, 1.5 parts by weight of carrageenan, 2.5 parts by weight of cocamidopropyl betaine, 0.3 part by weight of mint essence, 0.4 part by weight of phenoxyethanol and 48 parts by weight of deionized water.
The whitening complex is prepared by the following method:
cleaning, airing and crushing picked fresh Chinese starjasmine leaves to 80 meshes to obtain Chinese starjasmine leaf powder; adding 8 parts by weight of Chinese starjasmine stem leaf powder into 50 parts by weight of extraction solvent, and carrying out ultrasonic treatment for 0.5h under the ultrasonic conditions of 500W and 30kHz, wherein the extraction solvent is deionized water; microwave extracting at 85 deg.C under 500W for 1.5 hr; filtering, concentrating the filtrate to 35% of the original weight, adding 3.5 parts by weight of perlite, uniformly mixing, and then performing ball milling treatment for 0.5h, wherein the ball-material ratio is 10; spray drying to obtain the final product.
The desensitizing agent is desensitizing salt beads; the desensitizing salt bead is prepared by the following method:
s1, dissolving 1.5 parts by weight of sodium alginate, 2 parts by weight of dextranase and 0.5 part by weight of strontium acetate in 80 parts by weight of deionized water to obtain a solution a; dispersing 1 weight part of potato starch in 20 weight parts of deionized water, then placing the mixture in a water bath at 70 ℃ and stirring the mixture for 20min at the rotating speed of 1000rpm, taking out the mixture and cooling the mixture to room temperature to obtain a dispersion liquid b; dissolving 1 part by weight of calcium chloride in 100 parts by weight of deionized water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotation speed of 1200rpm for 15min, then adding 0.15 part by weight of cross-linking agent, continuing to stir, adding the solution c after 5min, continuing to stir for 40min, filtering out balls, washing with deionized water for three times, and drying at 50 ℃ for 8h to obtain desensitizing salt beads.
The cross-linking agent is a mixture of sodium tripolyphosphate and adipic acid, wherein the mass ratio of the sodium tripolyphosphate to the adipic acid is 2.
The preparation method of the whitening and antibacterial toothpaste comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, a desensitizer, a whitening compound, hydrated silica and phenoxyethanol into water according to the parts by weight, mixing and dispersing, adding the mixture into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 2min at the stirring speed of 180rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 25min at the stirring speed of 50rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 10min at the stirring speed of 50rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree at-0.09 MPa, stirring for 12min at the speed of 50rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) Pouring out the paste from the vacuum paste making machine, filling into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste. Wherein the CAULIS Trachelospermi leaf is leaf of CAULIS Trachelospermi (Trachelospermi CAULIS ET FOLIUM) in the above steps; the particle size of the perlite is 200 meshes.
Test example 1
And (3) whitening performance test: soaking 30 acid-etched enamel blocks in a dyeing solution (a mixed solution of black tea, gastric mucin, ferric chloride and water) at 37 deg.C for one week, taking out, and smoking with tobacco for 30min to obtain dyed enamel blocks. Then fixing on an L8-II cross tooth brushing machine, randomly dividing into 2 groups, 15 blocks in each group, adopting the whitening and antibacterial toothpaste of the embodiments 7 and 8 respectively to simulate tooth brushing for 8000 times, cleaning and drying. And measuring the color of enamel before and after tooth brushing by using a color difference meter, wherein the color is recorded as L0 before tooth brushing and is recorded as L1 after tooth brushing. Whitening ratio% = (L1-L0)/L0 × 100%.
TABLE 1 desensitization Effect test results
| Whitening ratio (%) | |
| Example 7 | 27.8 |
| Example 8 | 25.2 |
Test example 2
Desensitization test:
(1) 120 subjects suffering from dentin hypersensitivity are selected, the age range is 18-55 years, 60 men and women are respectively selected and divided into 6 groups, 10 women and 10 men in each group respectively use the whitening and antibacterial toothpaste prepared by the embodiments 1-6 of the invention, the whitening and antibacterial toothpaste is used once in the morning and at the evening every day, 3min each time, and the whitening and antibacterial toothpaste is continuously used for one month. The curative effect was observed before and after 4 weeks of anti-allergy treatment.
(2) Subjects were tested before and 4 weeks after treatment, respectively: air is blown for 3s at a position which is about 3mm away from the root surface of the tooth to be detected by using a three-way air gun (60kPa, 20 ℃) on a dental chair, and the adjacent teeth are covered by fingers with rubber gloves during detection. The sensitivity of the tested teeth was judged by visual analogical pain scoring, and the subject was asked to record the discomfort of the tested teeth to the temperature test on a 10cm visual scale, the 0 and 10cm ends of which represent no discomfort or no pain and severe discomfort or severe pain, respectively. The degree of sensitivity of the subject's teeth to air stimuli was assessed using a visual analog pain score before and after 4 weeks of anti-sensitivity treatment.
TABLE 2 desensitization Effect test results
| Before anti-allergy treatment | After 4 weeks of anti-allergy treatment | |
| Example 1 | 5.65 | 3.62 |
| Example 2 | 5.64 | 2.96 |
| Example 3 | 5.65 | 2.48 |
| Example 4 | 5.67 | 2.15 |
| Example 5 | 5.66 | 2.13 |
| Example 6 | 5.65 | 2.01 |
As can be seen from the above, compared with example 1, the desensitization effect of example 2 is more obvious, probably because the gelation reaction between uronic acid in sodium alginate and calcium ions is adopted to form rigid gel to encapsulate dextranase in example 2, the problem of compatibility between dextranase and other components in toothpaste is solved, the stability of toothpaste is improved, and the enzyme activity of dextranase in toothpaste is ensured, so that the desensitization effect is obviously improved. The desensitizing effect of examples 3-6 is better than that of example 2, probably because the addition of potato starch in the desensitizing salt bead preparation (example 3) serves to increase viscosity and prevent the loss of enzymes from the desensitizing salt beads on the one hand, and the gelatinized starch (examples 4-6) also serves as a pore-forming agent to accelerate the release of enzymes during toothpaste application, thereby further improving the desensitizing effect.
Test example 3
And (3) testing the bacteriostatic effect: the bacteriostatic rate of the whitening bacteriostatic toothpaste described in examples 1-6 on staphylococcus aureus (ATCC 6538) and candida albicans (ATCC 10231) was tested by referring to the bacteriostatic effect test method (suspension quantification method) of bacteriostatic daily chemical products in QB/T2738-2012, evaluation method of antibacterial and bacteriostatic effects of daily chemical products.
TABLE 3 results of the bacteriostatic effect test
The test results show that the toothpaste prepared by the invention has good antibacterial effect, can inhibit the breeding of oral bacteria, and can strengthen the roots and strengthen the teeth; particularly, when the desensitization salt beads prepared by the invention are added into toothpaste, the bacteriostasis rate reaches 90% or more, and the desensitization salt beads have a positive effect on improving the anti-sensitivity capability of teeth.
Claims (3)
1. The whitening and antibacterial toothpaste is characterized by comprising the following raw materials: the composition is characterized by comprising the following raw materials in parts by weight: 0.3-0.6 part of hyaluronic acid, 1-3 parts of medical stone, 0.5-2 parts of natural tea tree oil, 0.1-0.5 part of vitamin C, 2-5 parts of desensitizer, 3-5 parts of whitening compound, 35-45 parts of hydrated silica, 10-20 parts of sorbitol, 0.5-2 parts of carrageenan, 1.5-3 parts of cocamidopropyl betaine, 0.1-0.5 part of mint essence, 0.1-0.5 part of phenoxyethanol and 35-50 parts of water;
the whitening compound is prepared by the following method:
cleaning, air drying and crushing Chinese starjasmine stem leaves to obtain Chinese starjasmine stem leaf powder; adding 5-8 parts by weight of Chinese starjasmine stem leaf powder into 40-50 parts by weight of extraction solvent for ultrasonic treatment for 0.5-1h, wherein the ultrasonic treatment condition is 300-500W and 20-30kHz, and the extraction solvent is 30-50wt% of glycerol aqueous solution; adding 0.5-1 weight part of malic acid and 0.5-0.8 weight part of sodium citrate, mixing, and microwave extracting at 80-90 deg.C under 350-500W for 1-3 hr; filtering, concentrating the filtrate to 25-35% of the original weight, adding 3-5 parts by weight of perlite, mixing uniformly, and performing ball milling treatment for 0.5-1h, wherein the ball-material ratio is 10 (1-3), and the ball milling rotation speed is 800-1000rpm; spray drying to obtain;
the desensitizing agent is desensitizing salt beads; the desensitizing salt bead is prepared by the following method:
s1, dissolving 1-2 parts by weight of sodium alginate, 1.5-3 parts by weight of dextranase and 0.5-1.2 parts by weight of strontium acetate in 75-85 parts by weight of water to obtain a solution a; dispersing 0.5-1.5 weight parts of potato starch in 15-25 weight parts of water, then placing in 68-78 deg.C water bath, stirring at 800-1200rpm for 15-30min, taking out, and cooling to room temperature to obtain dispersion liquid b; dissolving 0.5-1.5 parts by weight of calcium chloride in 50-150 parts by weight of water to obtain a solution c;
s2, adding the dispersion liquid b into the solution a, stirring at the rotating speed of 1000-1500rpm for 10-20min, then adding 0.1-0.3 part by weight of a cross-linking agent, continuing to stir, adding the solution c after 3-8min, continuing to stir for 30-60min, filtering out small balls, washing with water, and drying at 45-60 ℃ for 6-10h to obtain desensitized salt beads.
2. The whitening and bacteriostatic toothpaste according to claim 1, wherein the cross-linking agent is one or more of glutaraldehyde, epichlorohydrin, sodium tripolyphosphate, glycol glycidyl ether and adipic acid.
3. The preparation method of the whitening and bacteriostatic toothpaste according to claim 1, which comprises the following steps:
(1) Adding hyaluronic acid, medical stone, natural tea tree oil, vitamin C, a desensitizer, a whitening compound, hydrated silica and phenoxyethanol into water according to the parts by weight, mixing and dispersing, adding into a vacuum paste making machine, adding sorbitol into the vacuum paste making machine, starting a stirrer, and stirring for 1-3min at the stirring speed of 160-200rpm;
(2) Adding carrageenan and cocoamidopropyl betaine into the vacuum paste making machine in the step (1) according to the mass parts, and stirring for 20-30min at the stirring speed of 30-60rpm;
(3) Adding the mint essence into a vacuum paste making machine according to the parts by weight, and stirring for 8-12min at the stirring speed of 30-60rpm;
(4) Opening a vacuum pump of the paste making machine for pumping vacuum, keeping the vacuum degree between-0.1 and-0.09 MPa, stirring for 10-15min at the speed of 30-60rpm, and then closing the vacuum pump and the stirrer to finish the paste making;
(5) And pouring the paste out of the vacuum paste making machine, filling the paste into a toothpaste hose, and sealing the tail by using a self-made tail sealing machine to obtain the whitening and antibacterial toothpaste.
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Effective date of registration: 20231026 Address after: 510000 room 3f-18, No. 01, third floor, northeast podium building, No. 111, Changdi street, Luju Road, Liwan District, Guangzhou, Guangdong Patentee after: GUANGZHOU HAPPY STRUGGLE INDUSTRIAL CO.,LTD. Address before: Room 205-211526, No. 40 Fuqian West Street, Pinggu Town, Fangshan District, Beijing, 101200 (cluster registration) Patentee before: BEIJING YONGBO TECHNOLOGY CO.,LTD. |