CN111053705A - Halitosis-improving toothpaste and preparation method thereof - Google Patents
Halitosis-improving toothpaste and preparation method thereof Download PDFInfo
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- CN111053705A CN111053705A CN201911421948.3A CN201911421948A CN111053705A CN 111053705 A CN111053705 A CN 111053705A CN 201911421948 A CN201911421948 A CN 201911421948A CN 111053705 A CN111053705 A CN 111053705A
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- 206010006326 Breath odour Diseases 0.000 title claims abstract description 57
- 208000032139 Halitosis Diseases 0.000 title claims abstract description 55
- 239000000606 toothpaste Substances 0.000 title claims abstract description 46
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 229920001661 Chitosan Polymers 0.000 claims abstract description 43
- 229940045110 chitosan Drugs 0.000 claims abstract description 43
- 102000016943 Muramidase Human genes 0.000 claims abstract description 23
- 108010014251 Muramidase Proteins 0.000 claims abstract description 23
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 23
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 23
- 239000004325 lysozyme Substances 0.000 claims abstract description 23
- 229960000274 lysozyme Drugs 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000001488 sodium phosphate Substances 0.000 claims abstract description 20
- 229910000162 sodium phosphate Inorganic materials 0.000 claims abstract description 20
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims abstract description 20
- 239000003906 humectant Substances 0.000 claims abstract description 19
- 239000002562 thickening agent Substances 0.000 claims abstract description 19
- 239000000654 additive Substances 0.000 claims abstract description 16
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 230000000996 additive effect Effects 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- 239000003082 abrasive agent Substances 0.000 claims abstract description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 23
- 235000011008 sodium phosphates Nutrition 0.000 claims description 19
- 238000002156 mixing Methods 0.000 claims description 14
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 12
- 239000001506 calcium phosphate Substances 0.000 claims description 12
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 12
- 229910000150 monocalcium phosphate Inorganic materials 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 12
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 11
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 11
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 11
- 239000000600 sorbitol Substances 0.000 claims description 11
- 239000000230 xanthan gum Substances 0.000 claims description 11
- 229920001285 xanthan gum Polymers 0.000 claims description 11
- 229940082509 xanthan gum Drugs 0.000 claims description 11
- 235000010493 xanthan gum Nutrition 0.000 claims description 11
- 230000008961 swelling Effects 0.000 claims description 8
- 230000002421 anti-septic effect Effects 0.000 claims description 7
- -1 antiseptic Substances 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000009849 vacuum degassing Methods 0.000 claims description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical group [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 5
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 5
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- 108700004121 sarkosyl Proteins 0.000 claims description 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 3
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 3
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 3
- 229940048086 sodium pyrophosphate Drugs 0.000 claims description 3
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 2
- YRWWOAFMPXPHEJ-OFBPEYICSA-K sodium L-ascorbic acid 2-phosphate Chemical compound [Na+].[Na+].[Na+].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] YRWWOAFMPXPHEJ-OFBPEYICSA-K 0.000 claims description 2
- 229940048058 sodium ascorbyl phosphate Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 5
- 210000000214 mouth Anatomy 0.000 description 8
- 206010042674 Swelling Diseases 0.000 description 7
- 208000006558 Dental Calculus Diseases 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 235000012239 silicon dioxide Nutrition 0.000 description 4
- 230000001575 pathological effect Effects 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000361919 Metaphire sieboldi Species 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 208000005888 Periodontal Pocket Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 208000019884 chronic gingivitis Diseases 0.000 description 1
- 208000001277 chronic periodontitis Diseases 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention discloses halitosis-improving toothpaste which comprises the following raw materials in percentage by weight: 16-22% of an abrasive agent, 50-75% of a humectant, 1-2% of a surfactant, 0.8-1.5% of a thickening agent, 0.1-0.3% of a preservative, 0.5-1.2% of essence, 2-6% of an active additive, a pH regulator and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate. The invention also discloses a preparation method of the halitosis-improving toothpaste. The invention has good halitosis improving effect.
Description
Technical Field
The invention relates to the technical field of toothpaste, in particular to halitosis-improving toothpaste and a preparation method thereof.
Background
Halitosis can be divided into non-pathological and pathological. The pathological halitosis can be classified into halitosis of mouth origin and halitosis of non-mouth origin according to their origins. According to statistics, 80-90% of the halitosis belongs to halitosis of oral origin. Most bad breath is associated with oral diseases and the ecological environment of the oral cavity. The accumulation of unclean mouth, plaque, tartar, and tartar is the most direct cause of halitosis. Patients with chronic gingivitis and periodontitis suffer from swelling and bleeding of gums, pus discharge from periodontal pockets, and poor oral hygiene, and plaque, tartar and tartar accumulated on teeth are decomposed and fermented by bacteria and microorganisms to generate unpleasant odor. Patients with necrotic gingivitis, malignant tumors, and infection after tooth extraction may have bad breath due to decomposition and suppuration of necrotic tissue, which produces earthworm noise, sulfhydryl, and limbs. In addition, untreated caries, stumps, crowns, defective restorations, and the like in the oral cavity are prone to deposit food residues and dirt, resulting in an unpleasant halitosis. At present, a plurality of toothpaste for removing halitosis are available on the market, but the curative effect is not obvious.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides the halitosis-improving toothpaste and the preparation method thereof.
The invention provides halitosis-improving toothpaste which comprises the following raw materials in percentage by weight: 16-22% of an abrasive agent, 50-75% of a humectant, 1-2% of a surfactant, 0.8-1.5% of a thickening agent, 0.1-0.3% of a preservative, 0.5-1.2% of essence, 2-6% of an active additive, a pH regulator and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate.
Preferably, the weight ratio of the chitosan to the lysozyme to the sodium ascorbyl phosphate is 2-4: 0.01-0.1: 0.5-1.
Preferably, the chitosan has a particle size of 10-15 μm.
Preferably, the chitosan is a porous chitosan.
Preferably, the abrasive is at least one of precipitated silica and monocalcium phosphate.
Preferably, the abrasive is precipitated silica and monocalcium phosphate, wherein the weight ratio of precipitated silica to monocalcium phosphate is 3-4: 1.
preferably, the humectant is at least one of sorbitol and glycerin.
Preferably, the humectant is sorbitol and glycerin, wherein the weight ratio of the sorbitol to the glycerin is 1: 2-3.
Preferably, the thickener is at least one of sodium carboxymethylcellulose and xanthan gum.
Preferably, the thickening agent is sodium carboxymethyl cellulose and xanthan gum, wherein the weight ratio of the sodium carboxymethyl cellulose to the xanthan gum is 1: 3-4.
Preferably, the surfactant is at least one of sodium lauryl sulfate and sodium lauroyl sarcosinate.
Preferably, the halitosis improving toothpaste has a pH of 6-6.5.
Preferably, the pH adjuster is at least one of sodium pyrophosphate and sodium dihydrogen phosphate.
Preferably, the preservative is sodium benzoate.
The raw materials all conform to GB 22115-2008 specification of raw materials for toothpaste.
The invention also discloses a preparation method of the halitosis-improving toothpaste, which comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding for two times (30-50 min each time), vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis improving toothpaste.
Has the advantages that:
on one hand, the invention selects chitosan and lysozyme to be matched with each other in a proper proportion, can inhibit and sterilize bacteria, kill harmful bacteria and odor causing bacteria in the oral cavity, improve the flora environment of the oral cavity, fundamentally improve the problem of halitosis, and adjust proper pH value to ensure that the lysozyme has good activity; on the other hand, the chitosan has a good odor adsorption effect, has a porous structure and is tiny in particles, and the adsorption performance is stronger, so that the odor can be well adsorbed, and the purpose of treating the symptoms is achieved; in addition, the chitosan and the vitamin C sodium phosphate are matched with each other, so that the gingival bleeding problem and the oral cavity problem can be improved, and the halitosis problem can be further relieved; the abrasive precipitated silica and the monocalcium phosphate can brush tartar on the surface of teeth without damaging the teeth, and the porous chitosan can adsorb tartar; the invention can remove halitosis and improve oral environment by matching the substances in a proper proportion.
Detailed Description
The technical solution of the present invention will be described in detail below with reference to specific examples.
Example 1
The halitosis-improving toothpaste comprises the following raw materials in percentage by weight: 16% of an abrasive, 75% of a humectant, 1% of a surfactant, 1.5% of a thickening agent, 0.3% of a preservative, 0.5% of essence, 6% of an active additive and a pH regulator, and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate.
The preparation method of the halitosis-improving toothpaste comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding for two times (30 min each time), vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis improving toothpaste.
Example 2
The halitosis-improving toothpaste comprises the following raw materials in percentage by weight: 22% of precipitated silica, 50% of sorbitol, 2% of sodium lauryl sulfate, 0.8% of xanthan gum, 0.1% of sodium benzoate, 1.2% of essence, 2% of active additives and sodium pyrophosphate, and the balance of water, wherein the active additives are porous chitosan, lysozyme and vitamin C sodium phosphate;
wherein the weight ratio of the chitosan to the lysozyme to the vitamin C sodium phosphate is 4: 0.01: 1;
the chitosan is porous chitosan, and the particle size of the chitosan is 10-15 μm; the pH of the halitosis improving toothpaste is 6-6.5.
The preparation method of the halitosis-improving toothpaste comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding twice, vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis-improving toothpaste.
Example 3
The halitosis-improving toothpaste comprises the following raw materials in percentage by weight: 18% of monocalcium phosphate, 55% of glycerol, 1.2% of sodium lauroyl sarcosinate, 1% of sodium carboxymethylcellulose, 0.25% of sodium benzoate, 0.9% of essence, 5% of active additives, sodium dihydrogen phosphate and the balance of water, wherein the active additives are porous chitosan, lysozyme and vitamin C sodium phosphate;
wherein the weight ratio of the chitosan to the lysozyme to the vitamin C sodium phosphate is 2: 0.1: 0.5;
the chitosan is porous chitosan, and the particle size of the chitosan is 10-15 μm; the pH of the halitosis improving toothpaste is 6-6.5.
The preparation method of the halitosis-improving toothpaste comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding twice, vacuum degassing for 45min to-0.095 MPa, standing, and sterilizing to obtain halitosis-improving toothpaste.
Example 4
The halitosis-improving toothpaste comprises the following raw materials in percentage by weight: 20% of an abrasive, 60% of a humectant, 1.8% of sodium lauryl sulfate, 1% of a thickening agent, 0.15% of sodium benzoate, 1.1% of essence, 3% of an active additive, sodium dihydrogen phosphate and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate;
wherein the weight ratio of the chitosan to the lysozyme to the vitamin C sodium phosphate is 2.5: 0.04: 0.6;
the chitosan is porous chitosan, and the particle size of the chitosan is 10-15 μm; the pH value of the halitosis-improving toothpaste is 6-6.5;
the friction agent is precipitated silicon dioxide and monocalcium phosphate, wherein the weight ratio of the precipitated silicon dioxide to the monocalcium phosphate is 3: 1;
the humectant is sorbitol and glycerin, wherein the weight ratio of the sorbitol to the glycerin is 1: 3;
the thickening agent is sodium carboxymethyl cellulose and xanthan gum, wherein the weight ratio of the sodium carboxymethyl cellulose to the xanthan gum is 1: 3.
the preparation method of the halitosis-improving toothpaste comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding for two times (35 min each time), vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis improving toothpaste.
Example 5
The halitosis-improving toothpaste comprises the following raw materials in percentage by weight: 19% of an abrasive, 55% of a humectant, 1.5% of sodium lauryl sulfate, 1% of a thickening agent, 0.2% of sodium benzoate, 1% of essence, 4% of an active additive, sodium dihydrogen phosphate and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate;
wherein, the weight ratio of the chitosan, the lysozyme and the vitamin C sodium phosphate is 3: 0.02: 0.7;
the chitosan is porous chitosan, and the particle size of the chitosan is 10-15 μm; the pH value of the halitosis-improving toothpaste is 6-6.5;
the friction agent is precipitated silicon dioxide and monocalcium phosphate, wherein the weight ratio of the precipitated silicon dioxide to the monocalcium phosphate is 4: 1;
the humectant is sorbitol and glycerin, wherein the weight ratio of the sorbitol to the glycerin is 1: 2;
the thickening agent is sodium carboxymethyl cellulose and xanthan gum, wherein the weight ratio of the sodium carboxymethyl cellulose to the xanthan gum is 1: 4.
the preparation method of the halitosis-improving toothpaste comprises the following steps: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding twice, vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis-improving toothpaste.
Test examples
60 persons (30 male and 30 female) with halitosis of oral origin were selected and randomly divided into 6 groups, 10 persons in each group were recorded as test groups 1-5 by brushing teeth with examples 1-5, and one group was recorded as a control group by brushing teeth with a commercial halitosis-removing toothpaste, wherein the weights and brushing times of the 6 groups of toothbrushing toothpastes were the same, and the breath values before and after brushing were measured, and the following results were obtained:
remarking: removal rate (oral breath before tooth brushing-oral breath after tooth brushing)/oral breath before tooth brushing 100%.
As can be seen from the above table, the present invention has a good halitosis-removing effect and a long lasting time.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (10)
1. The halitosis-improving toothpaste is characterized by comprising the following raw materials in percentage by weight: 16-22% of an abrasive agent, 50-75% of a humectant, 1-2% of a surfactant, 0.8-1.5% of a thickening agent, 0.1-0.3% of a preservative, 0.5-1.2% of essence, 2-6% of an active additive, a pH regulator and the balance of water, wherein the active additive is porous chitosan, lysozyme and vitamin C sodium phosphate.
2. The toothpaste for improving halitosis according to claim 1, wherein the weight ratio of chitosan, lysozyme and sodium ascorbyl phosphate is 2-4: 0.01-0.1: 0.5-1.
3. The toothpaste for improving halitosis according to claim 1 or 2, wherein the particle size of the chitosan is 10-15 μm; preferably, the chitosan is a porous chitosan.
4. The halitosis-improving toothpaste according to any one of claims 1-3, wherein the abrasive is at least one of precipitated silica and monocalcium phosphate; preferably, the abrasive is precipitated silica and monocalcium phosphate, wherein the weight ratio of precipitated silica to monocalcium phosphate is 3-4: 1.
5. the toothpaste for improving halitosis according to any one of claims 1-4, wherein the humectant is at least one of sorbitol and glycerin; preferably, the humectant is sorbitol and glycerin, wherein the weight ratio of the sorbitol to the glycerin is 1: 2-3.
6. The toothpaste for improving halitosis according to any one of claims 1-5, wherein the thickener is at least one of sodium carboxymethylcellulose and xanthan gum; preferably, the thickening agent is sodium carboxymethyl cellulose and xanthan gum, wherein the weight ratio of the sodium carboxymethyl cellulose to the xanthan gum is 1: 3-4.
7. The toothpaste according to any one of claims 1 to 6, wherein the surfactant is at least one of sodium lauryl sulfate and sodium lauroyl sarcosinate.
8. The halitosis-improving toothpaste according to any one of claims 1-7, wherein the halitosis-improving toothpaste has a pH of from 6 to 6.5; preferably, the pH adjuster is at least one of sodium pyrophosphate and sodium dihydrogen phosphate.
9. The toothpaste according to any one of claims 1 to 3, wherein the preservative is sodium benzoate.
10. A method of preparing a halitosis-improving toothpaste according to any of claims 1-9, comprising the steps of: mixing humectant and thickener, adding water solution of vitamin C sodium phosphate, standing for swelling, adding water solution of pH regulator, mixing, adding abrasive, surfactant, antiseptic, essence, porous chitosan and lysozyme, grinding for two times (30-50 min each time), vacuum degassing to-0.095 MPa, standing, and sterilizing to obtain halitosis improving toothpaste.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911421948.3A CN111053705A (en) | 2019-12-31 | 2019-12-31 | Halitosis-improving toothpaste and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111743834A (en) * | 2020-07-06 | 2020-10-09 | 三椒口腔健康股份有限公司 | Edelweiss toothpaste and preparation method thereof |
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| CN1682685A (en) * | 2005-03-11 | 2005-10-19 | 黄恒燊 | Health tooth paste composition |
| CN102802602A (en) * | 2009-06-08 | 2012-11-28 | 狮王株式会社 | Composition for oral cavity |
| CN108078802A (en) * | 2018-01-24 | 2018-05-29 | 深圳市芭格美生物科技有限公司 | A kind of toothpaste and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1682685A (en) * | 2005-03-11 | 2005-10-19 | 黄恒燊 | Health tooth paste composition |
| CN102802602A (en) * | 2009-06-08 | 2012-11-28 | 狮王株式会社 | Composition for oral cavity |
| CN108078802A (en) * | 2018-01-24 | 2018-05-29 | 深圳市芭格美生物科技有限公司 | A kind of toothpaste and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111743834A (en) * | 2020-07-06 | 2020-10-09 | 三椒口腔健康股份有限公司 | Edelweiss toothpaste and preparation method thereof |
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