CN107375123B - Alkalescent Chinese herbal medicine denture cleaning tablet - Google Patents
Alkalescent Chinese herbal medicine denture cleaning tablet Download PDFInfo
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- CN107375123B CN107375123B CN201710453779.6A CN201710453779A CN107375123B CN 107375123 B CN107375123 B CN 107375123B CN 201710453779 A CN201710453779 A CN 201710453779A CN 107375123 B CN107375123 B CN 107375123B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The invention discloses a weakly alkaline Chinese herbal medicine denture cleaning tablet. The cleaning tablet is composed of peroxide, adhesive, organic acid, lubricant, gamboge extract, high-temperature bamboo charcoal powder and other components, is superior to other conventional effervescent tablets, is not influenced by environmental temperature, and has the advantages of high disintegration and dissolution speed and high efficiency; the cleaning sheet is alkalescent and contains traditional Chinese medicine components, can effectively clean false teeth, effectively remove exogenous color spots, reduce fungi and remove dirt and tea dirt, particularly can remove peculiar smell generated by the false teeth, also solves the problems that the false teeth are easy to damage, deform, reduce the service life and the like due to soaking and washing by hot water or alcohol, and the soaked and cleaned false teeth are directly worn without washing by clear water, can effectively prevent and treat false tooth stomatitis, and can effectively prevent complications such as bacteremia and the like.
Description
Technical Field
The invention belongs to the field of denture cleaning and nursing products, and particularly relates to a weakly alkaline Chinese herbal medicine denture cleaning tablet and a preparation method thereof.
Background
Oral care health care is an essential important part of daily life, and the 21 st century proposes a new oral care concept that oral health is an integral part of life quality and improves life quality by maintaining oral health. The data show that the population of the next year of 60 years and above in China is nearly two hundred million, and more than 26 percent of people wear false teeth, because the oral tissue structure has a series of aging changes with age, the flow and quality of saliva are changed, the non-irritant salivary flow rate is obviously reduced, mucin and protamine which prevent bacteria from adhering to the surface of a tooth body in the saliva and maintain the health of the oral tissue are obviously reduced, and the feeling of xerostomia appears, so that the self-purification effect in the oral cavity of the old people is reduced, and the plans of the old people for generating periodontitis and decayed teeth are increased. Meanwhile, the gingival is aged and atrophied, so that the clinical periodontal attachment level is reduced, the interproximal space is exposed, and food is embedded, and the incidence of facial caries of the old is obviously increased. The increase of the age is also related to the periodontal disease, the people aged over 65 years often have osteoporosis, the alveolar bone loss rate of the osteoporosis is 9 times higher than that of the people aged 35-45 years, and the osteoporosis is a high-risk period of the periodontal disease. So that the old does not protect the teeth well and the old's teeth fall off or are damaged quickly. At this time, chewing with the aid of dentures is required, but the disease caused by the wrong way of cleaning dentures is damaging the health of many elderly people, and most seriously, causes the occurrence of denture stomatitis. Denture stomatitis refers to inflammatory lesions that occur in the palatal and gingival mucosa that abut against removable dentures. This is one of the most common clinical problems of patients with movable dentures, and the lesions are mainly manifested as bright red edema, yellowish white streak or stippled pseudomembranous mucosa. The patient feels a dry mouth and has burning pain in the mouth. In short, denture stomatitis is inflammation of the oral cavity due to improper use of a denture (artificial tooth), and is not caused by improper manufacture of the denture, but caused by improper use of the denture by a patient without paying attention to oral hygiene. Some people are too troublesome to wear the false teeth in the mouth for a long time and do not take down the false teeth to wash after eating a meal every time, so that a lot of food residues, builds and the like are embedded in the mouth. The surface of the false tooth is provided with a plurality of micropores which are beneficial to bacterial deposition, for bacteria, the oral cavity is a 'stuttered' paradise, the bacteria grow and multiply in a large quantity, metabolites of the bacteria cause halitosis, oral mucosa is stimulated to cause inflammation, large area of mucosa is red, swollen and painful, and thus 'denture stomatitis' is formed.
Disclosure of Invention
The traditional denture cleaning method has the defects of poor decontamination effect, slow disintegration speed, great influence of environmental temperature, residue precipitation, frequent damage to dentures and the like. The invention aims to provide a denture cleaning tablet containing Chinese herbal medicines, which is convenient to carry and use, contains natural Chinese herbal medicines and can be quickly disintegrated when meeting water, the denture cleaning tablet is alkalescent, the denture oral cleaning care solution containing the Chinese herbal medicines can effectively clean dentures, effectively remove exogenous color spots, reduce fungi, remove dirt and tea dirt, particularly, the cleaning tablet added with the Chinese herbal medicine component gamboge extract can remove peculiar smell generated by the dentures, and also solves the problems that the dentures are easy to damage, deform, reduce the service life and the like caused by soaking and washing with hot water or alcohol, and the soaked and cleaned dentures are directly worn without being washed with clear water, so that the denture oral inflammation can be effectively prevented and treated, and simultaneously complications such as bacteremia and the like can be effectively prevented.
The invention aims to provide a weakly alkaline Chinese herbal medicine denture cleaning tablet.
The technical scheme adopted by the invention is as follows:
a weakly alkaline Chinese herbal medicine denture cleaning tablet comprises the following components in parts by weight: 30-55 parts of peroxide, 0.5-10.0 parts of adhesive, 10-23 parts of organic acid, 1-5 parts of lubricant, 22-30 parts of carbonate or/and bicarbonate, 0.5-8 parts of cleaning agent, 0.5-10 parts of synergist, 0.5-5 parts of gamboge extract, 0.1-0.3 part of high-temperature bamboo charcoal powder and 0.1-3 parts of essence and spice;
the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of (1-2): 1: (5-10) in a weight ratio.
Further, the weakly alkaline denture cleaning tablet comprises the following components in parts by weight: 41.7 parts of peroxide, 4 parts of adhesive, 18 parts of organic acid, 4 parts of lubricant, 22 parts of carbonate or/and bicarbonate, 3 parts of cleaning agent, 3 parts of synergist, 3 parts of gamboge extract, 0.3 part of high-temperature bamboo charcoal powder and 1 part of essence and spice;
the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of 1: 1: 5 in weight ratio.
Further, the binder is selected from at least one of sodium carboxymethyl cellulose, mannitol, sorbitol and modified starch.
Further, the organic acid is at least one selected from citric acid, malic acid, tartaric acid, sodium citrate and sarcosine.
Further, the lubricant is hydroxyapatite.
Further, the carbonate or/and bicarbonate is at least one selected from sodium carbonate, sodium bicarbonate and calcium bicarbonate.
Further, the cleaning agent is selected from at least one of cocoyl oxybenzene sulfonate, sodium lauryl sulfate, sodium cocoyl glutamate and betaine.
Further, the synergist is at least one of EDTA-disodium, EDTA-tetrasodium and sodium pyrophosphate.
Further, the essence and flavor is selected from at least one of menthol and borneol.
A method for preparing weakly alkaline Chinese herbal medicine denture cleaning tablets comprises the following steps: adding organic acid, cleaning agent, adhesive, lubricant and synergist into a mixer, mixing and grinding; adding essence, perfume, carbonate and/or bicarbonate, grinding, and mixing; finally adding peroxide, gamboge extract and high-temperature bamboo charcoal powder and uniformly stirring; tabletting the obtained mixed powder by a tabletting machine to obtain the alkalescent denture cleaning tablet; the amounts of the respective raw materials are as described in any one of the above.
The invention has the beneficial effects that:
(1) the denture cleaning tablet prepared by the invention is alkalescent, is used as a denture effervescent tablet, is superior to other conventional effervescent tablets, is not influenced by environmental temperature, has very high disintegrating and dissolving speed and high efficiency, and has the defects of larger influence of temperature, low disintegrating speed and the like when being added with hydrolytic protease. The denture cleaning tablet provided by the invention is alkalescent, contains specific traditional Chinese medicine components, can effectively clean dentures, effectively remove exogenous color spots, reduce fungi, and remove dirt and tea scale. Particularly, the cleaning tablet added with the gamboge extract serving as the traditional Chinese medicine component can remove the peculiar smell generated by the false teeth, solves the problems that the false teeth are easy to damage and deform, the service life is shortened and the like due to soaking and washing by hot water or alcohol, is worn directly after soaking and cleaning, does not need to be washed by clean water, can effectively prevent and treat the false teeth stomatitis, and simultaneously effectively prevents complications such as bacteremia and the like.
(2) The invention changes the formula to make the product alkalescent, is more beneficial to oral health and can reduce the production of bacteria and fungi.
(3) The product of the invention has super strong adsorption function and the effects of generating negative ions, radiating far infrared rays, increasing alkalinity and the like. Has special adsorption capacity, can be adsorbed on the false teeth, and has the functions of decontamination, whitening, purification, disinfection and bacteriostasis on the false teeth in the using process.
(4) The gamboge extract and the high-temperature bamboo charcoal powder in the formula of the invention can play a synergistic role in the formula, and can adsorb bacteria and exogenous stains on the surface of the false tooth, thereby playing roles in cleaning the false tooth, whitening the tooth, refreshing breath and maintaining periodontal tissues.
(5) The components of the cleaning sheet of the present invention are free from the surface of the material and absorbed by body tissue, and new tissue grows. Has high bioactivity and can be used for repairing teeth.
Detailed Description
A weakly alkaline Chinese herbal medicine denture cleaning tablet comprises the following components in parts by weight: 30-55 parts of peroxide, 0.5-10.0 parts of adhesive, 10-23 parts of organic acid, 1-5 parts of lubricant, 22-30 parts of carbonate or/and bicarbonate, 0.5-8 parts of cleaning agent, 0.5-10 parts of synergist, 0.5-5 parts of gamboge extract, 0.1-0.3 part of high-temperature bamboo charcoal powder and 0.1-3 parts of essence and spice;
the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of (1-2): 1: (5-10) in a weight ratio.
Preferably, the weakly alkaline denture cleaning tablet consists of the following components in parts by weight: 41.7 parts of peroxide, 4 parts of adhesive, 18 parts of organic acid, 4 parts of lubricant, 22 parts of carbonate or/and bicarbonate, 3 parts of cleaning agent, 3 parts of synergist, 3 parts of gamboge extract, 0.3 part of high-temperature bamboo charcoal powder and 1 part of essence and spice;
the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of 1: 1: 5 in weight ratio.
Preferably, the binder is at least one selected from the group consisting of sodium carboxymethylcellulose, mannitol, sorbitol, and modified starch.
Preferably, the organic acid is at least one selected from citric acid, malic acid, tartaric acid, sodium citrate and sarcosine.
Preferably, the lubricant is hydroxyapatite.
Preferably, the carbonate or/and bicarbonate is selected from at least one of sodium carbonate, sodium bicarbonate and calcium bicarbonate.
Preferably, the detergent is selected from at least one of cocoyl oxybenzene sulfonate, sodium lauryl sulfate, sodium cocoyl glutamate and betaine.
Preferably, the synergist is at least one selected from EDTA-disodium, EDTA-tetrasodium and sodium pyrophosphate.
Preferably, the essence and flavor is selected from at least one of menthol and borneol.
Preferably, the preparation method of the gamboge extract comprises the following steps: before blooming, cutting bark of stem of Garcinia cambogia, collecting resin flowing out from the wound, evaporating to dryness, and extracting with water or organic solvent to obtain extractive solution; concentrating the extractive solution under reduced pressure; refrigerating at 0-10 deg.C for more than 24 hr; vacuum filtering; then selecting polyvinylidene fluoride ultrafiltration membrane with molecular weight cutoff of 10 ten thousand for ultrafiltration; adding saturated solution of embedding agent with weight of 2-10% into the ultrafiltration permeated liquid, and stirring and embedding; freeze drying or spray drying to obtain resina Garciniae extract.
Preferably, the organic solvent is at least one selected from ethanol, n-hexane and acetone.
Preferably, the embedding agent is at least one selected from modified starch, β -cyclodextrin, maltodextrin, starch syrup dry powder and acacia gum.
A method for preparing weakly alkaline Chinese herbal medicine denture cleaning tablets comprises the following steps: adding organic acid, cleaning agent, adhesive, lubricant and synergist into a mixer, mixing and grinding; adding essence, perfume, carbonate and/or bicarbonate, grinding, and mixing; finally adding peroxide, gamboge extract and high-temperature bamboo charcoal powder and uniformly stirring; tabletting the obtained mixed powder by a tabletting machine to obtain the alkalescent denture cleaning tablet; the amounts of the respective raw materials are as described in any one of the above.
The present invention will be further described with reference to the following examples.
Examples 1 to 3
The specific formulation of a weakly basic herbal denture cleanser prepared in examples 1-3 is shown in the following table:
the method for preparing the weakly alkaline Chinese herbal medicine denture cleaning tablet in the embodiment 1-3 comprises the following steps: weighing the raw materials according to the formula in the table, adding the organic acid, the cleaning agent, the adhesive, the lubricant and the synergist into a mixer, mixing and grinding; adding essence, perfume, carbonate or bicarbonate, grinding, and mixing; finally adding peroxide, gamboge extract and high-temperature bamboo charcoal powder and uniformly stirring; tabletting the obtained mixed powder by a tabletting machine to obtain the alkalescent denture cleaning tablet.
The adhesive comprises sodium carboxymethyl cellulose, mannitol, sorbitol and modified starch; the organic acid comprises citric acid, malic acid, tartaric acid, sodium citrate, and sarcosine; the lubricant is hydroxyapatite, and the carbonate or/and the bicarbonate is/are sodium carbonate, sodium bicarbonate and calcium bicarbonate; the cleanser comprises cocoyl oxysulfonate, sodium lauryl sulfate, sodium cocoyl glutamate and betaine; the synergist comprises at least one of EDTA-disodium, EDTA-tetrasodium and sodium pyrophosphate; the essence and spice comprises menthol and borneol. The peroxide is carbamide peroxide, pyrophosphate and percarbonate.
The preparation method of the gamboge extract comprises the steps of cutting the bark of a stem in a spiral shape at a position about 3 meters away from the ground before flowering, inserting a bamboo slip into a wound, collecting the flowing resin, heating to evaporate to dryness, scraping with a knife, extracting by a water extraction method or an organic solvent (ethanol) containing extraction method to obtain an extracting solution, finally concentrating the extracting solution or mother liquor under reduced pressure, refrigerating for more than 24 hours at the temperature of 0-10 ℃, carrying out vacuum filtration by using a 200-mesh filter screen, selecting a polyvinylidene fluoride ultrafiltration membrane with the molecular weight cutoff of 10 ten thousand for ultrafiltration, adding a saturated solution of an embedding agent (β -cyclodextrin) with the weight of 2-10% into the ultrafiltrated liquid, stirring and embedding, and carrying out freeze drying or spray drying to obtain the gamboge extract.
Further effect tests were conducted on the weakly alkaline denture cleansing sheet prepared according to the present invention.
First, disintegration effect detection
The method comprises the following steps: the same weight of denture cleansing tablets of the present invention, denture cleansing tablets of certain brands 1 and denture cleansing tablets of certain brands 2 were subjected to the measurement of disintegration rate under the same conditions, while setting different temperature conditions.
As a result: the test results are shown in table 1, and it can be seen that the denture cleaning tablet of the present invention has an average disintegration rate of about 92s, and the dissolved denture cleaning solution has no sediment residue; the denture cleaning tablet is not influenced by the environmental temperature, has very high disintegration and dissolution speed and high efficiency, has good stability at different temperatures, is not influenced by the temperature of liquid, and is obviously superior to the existing denture cleaning tablets sold in the market.
TABLE 1 disintegration time of denture cleansing tablets of the present invention at different water temperatures
Secondly, acid-base detection
According to the detection method, GB/T9724-2007 shows that through testing, the pH value of the cleaning solution after the denture cleaning sheet prepared by the invention is dissolved is 7-8.5, and the cleaning solution is alkalescent. The test results of repeated times are all between 7 and 8.5, and are all alkalescent.
| Sample (I) | Inventive sample 1 | Inventive sample 2 | Inventive sample 3 |
| pH value | 7.8 | 8.2 | 7.7 |
Third, detection of bacteriostatic action
The detection method is carried out according to the regulation of 'cosmetic hygiene standard'.
The denture cleaning tablet of the invention is prepared into aqueous solution with the concentration of 6 percent, and the oral cavity has the following bacteria: the staphylococcus aureus, the escherichia coli and the mould are used for sterilization tests, and the sterilization rate result is counted as follows:
note that: the water temperature is 25 ℃, the sign of + is negative, the sign of ++++++ indicates that the sterilization rate is more than 99%, the sign of ++++ indicates that the sterilization rate is 90-99%, the sign of +++++++++ indicates that the sterilization rate is 80-90%, the sign of ++ indicates that the sterilization rate is 50-80%, the sign of + indicates that the sterilization rate is 0-50%, and the sign of-is negative.
The test result shows that the formula of the invention has good sterilization effect on common bacteria and is obviously superior to other products.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (3)
1. The weakly alkaline Chinese herbal medicine denture cleaning tablet is characterized by comprising the following components in parts by weight: 30-55 parts of peroxide, 0.5-10.0 parts of adhesive, 10-23 parts of organic acid, 1-5 parts of lubricant, 22-30 parts of carbonate or/and bicarbonate, 0.5-8 parts of cleaning agent, 0.5-10 parts of synergist, 0.5-5 parts of gamboge extract, 0.1-0.3 part of high-temperature bamboo charcoal powder and 0.1-3 parts of essence and spice;
wherein the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of (1-2): 1: (5-10) by weight;
the binder is selected from at least one of sodium carboxymethyl cellulose, mannitol, sorbitol and modified starch;
the organic acid is at least one of citric acid, malic acid, tartaric acid, sodium citrate and sarcosine;
the lubricant is hydroxyapatite;
the carbonate or/and bicarbonate is/are at least one of sodium carbonate, sodium bicarbonate and calcium bicarbonate;
the cleaning agent is selected from at least one of cocoyl oxysulfonate, sodium lauryl sulfate, sodium cocoyl glutamate and betaine;
the synergist is at least one of EDTA-disodium, EDTA-tetrasodium and sodium pyrophosphate;
the essence and flavor is at least one of menthol and borneol.
2. The weakly basic Chinese herbal medicine denture cleaning tablet according to claim 1, which is characterized by comprising the following components in parts by weight: 41.7 parts of peroxide, 4 parts of adhesive, 18 parts of organic acid, 4 parts of lubricant, 22 parts of carbonate or/and bicarbonate, 3 parts of cleaning agent, 3 parts of synergist, 3 parts of gamboge extract, 0.3 part of high-temperature bamboo charcoal powder and 1 part of essence and spice;
the peroxide is prepared from carbamide peroxide, pyrophosphate and percarbonate according to the weight ratio of 1: 1: 5 in weight ratio.
3. A preparation method of weakly alkaline Chinese herbal medicine denture cleaning tablets is characterized by comprising the following steps: adding organic acid, cleaning agent, adhesive, lubricant and synergist into a mixer, mixing and grinding; adding essence, perfume, carbonate and/or bicarbonate, grinding, and mixing; finally adding peroxide, gamboge extract and high-temperature bamboo charcoal powder and uniformly stirring; tabletting the obtained mixed powder by a tabletting machine to obtain the alkalescent denture cleaning tablet;
the amount of each of the above raw materials is as defined in any one of claims 1 to 2.
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| JP7463047B1 (en) | 2023-09-01 | 2024-04-08 | 小林製薬株式会社 | Oral appliance cleaner |
| JP7502577B1 (en) | 2024-03-13 | 2024-06-18 | 小林製薬株式会社 | Oral appliance cleaner for effervescent tablets |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1179972A (en) * | 1997-09-29 | 1998-04-29 | 杨成玉 | Multifunctional effervescent for cleaning mouth |
| BRPI0907646A2 (en) * | 2008-02-08 | 2015-07-21 | Colgate Palmolive Co | Effervescent soluble solid composition, and method for cleaning a dental device |
| TW201031430A (en) * | 2008-11-17 | 2010-09-01 | Glaxosmithkline Llc | Dental appliance cleanser |
| CN102552054B (en) * | 2010-12-24 | 2013-06-12 | 南京华狮化工有限公司 | Effervescent tablet for false teeth as well as preparation method and application of effervescent tablet |
| CN104127711A (en) * | 2014-08-10 | 2014-11-05 | 郭志平 | Traditional Chinese medicine collutory for treating orthodontic gingivitis and preparation method thereof |
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