CN110302067A - A kind of adjuvant and preparation method thereof having tooth whitening and repair function - Google Patents
A kind of adjuvant and preparation method thereof having tooth whitening and repair function Download PDFInfo
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- CN110302067A CN110302067A CN201810229333.XA CN201810229333A CN110302067A CN 110302067 A CN110302067 A CN 110302067A CN 201810229333 A CN201810229333 A CN 201810229333A CN 110302067 A CN110302067 A CN 110302067A
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- adjuvant
- tooth
- tooth whitening
- bioactivity glass
- repairs
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- 230000002087 whitening effect Effects 0.000 title claims abstract description 64
- 239000002671 adjuvant Substances 0.000 title claims abstract description 34
- 230000008439 repair process Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000011521 glass Substances 0.000 claims abstract description 68
- 239000000606 toothpaste Substances 0.000 claims abstract description 41
- 229940034610 toothpaste Drugs 0.000 claims abstract description 41
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000004061 bleaching Methods 0.000 claims abstract description 16
- 229920002521 macromolecule Polymers 0.000 claims abstract description 13
- 210000000214 mouth Anatomy 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims abstract description 5
- 229940112822 chewing gum Drugs 0.000 claims abstract description 3
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 3
- 229920001661 Chitosan Polymers 0.000 claims description 22
- 239000000243 solution Substances 0.000 claims description 13
- 239000011259 mixed solution Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
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- 239000003292 glue Substances 0.000 claims description 5
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- 238000012986 modification Methods 0.000 claims description 5
- 230000004048 modification Effects 0.000 claims description 5
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- 238000002604 ultrasonography Methods 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
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- 239000005714 Chitosan hydrochloride Substances 0.000 claims description 2
- 241000196324 Embryophyta Species 0.000 claims description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000000783 alginic acid Substances 0.000 claims description 2
- 235000010443 alginic acid Nutrition 0.000 claims description 2
- 229920000615 alginic acid Polymers 0.000 claims description 2
- 229960001126 alginic acid Drugs 0.000 claims description 2
- 150000004781 alginic acids Chemical class 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 229930195712 glutamate Natural products 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
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- 238000003756 stirring Methods 0.000 claims description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 1
- DSLZVSRJTYRBFB-DUHBMQHGSA-N galactaric acid Chemical class OC(=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O DSLZVSRJTYRBFB-DUHBMQHGSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000003628 erosive effect Effects 0.000 abstract description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 239000005312 bioglass Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 18
- 239000000203 mixture Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 8
- 239000007789 gas Substances 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 239000007844 bleaching agent Substances 0.000 description 6
- 239000013256 coordination polymer Substances 0.000 description 6
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
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- 229910052906 cristobalite Inorganic materials 0.000 description 3
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- 239000000523 sample Substances 0.000 description 3
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- 229910052682 stishovite Inorganic materials 0.000 description 3
- 229910052905 tridymite Inorganic materials 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010054949 Metaplasia Diseases 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000005313 bioactive glass Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
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- 238000011160 research Methods 0.000 description 2
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- 206010067484 Adverse reaction Diseases 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
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- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- 239000004098 Tetracycline Substances 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000004509 Tooth Discoloration Diseases 0.000 description 1
- 208000000311 Tooth Migration Diseases 0.000 description 1
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- 206010044041 Tooth hypoplasia Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
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- 238000004166 bioassay Methods 0.000 description 1
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- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
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- 239000006071 cream Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
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- 208000002925 dental caries Diseases 0.000 description 1
- 201000002268 dental enamel hypoplasia Diseases 0.000 description 1
- 208000004042 dental fluorosis Diseases 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
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- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 230000032724 odontogenesis Effects 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical group O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- 229960002180 tetracycline Drugs 0.000 description 1
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- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 230000036367 tooth discoloration Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of adjuvants and preparation method thereof for having tooth whitening and repair function.The adjuvant can prevent whitening agent urea peroxide and bioactivity glass class repair materials from chemical reaction occurs and inactivates.In use, water-soluble macromolecule coating meets water and occurs to be disintegrated slow-release bio glass ingredient, realizes the double effects of tooth whitening and Dental Erosion；It also avoids bioactivity glass and urea peroxide to react and cause toothpaste tube expansion simultaneously, improves product stability, extend shelf life of products.The preparation method of the adjuvant is simple, and raw material is next from a wealth of sources, low in cost, easy to operate, is conducive to industrialized production.The adjuvant can be used for the whitening teeth object in various oral cavities, such as toothpaste, chewing gum, embrocate tooth powder, tooth patch, bleaching gel, have a good application prospect.
Description
Technical field
The invention belongs to oral care techniques field, in particular to a kind of adjuvant for having tooth whitening and repair function and
Preparation method.
Background technique
In China, as change of age, chronic dietary and bad life habits can all cause various influences to tooth,
In one it is most common the result is that tooth discoloration, if tooth is dimmed, turn yellow, nigrescence wait color change.Tooth is most common
Color is mainly shown as caused by coffee, dark food and smoking due to the excessive food such as tea for eating some easy colorings
Bacteriogenic pigment deposition in external pigment or oral cavity.If taking some drugs when tooth development, fluoride it is excessive
Intake or the use of teeth repairing material can all cause to colour, such as tetracycline pigmentation teeth, den tal fluorosis, enamel hypoplasia etc..So
And possessing the pure white tooth of a secondary health is that people pursue a nature of beauty, tooth whitening gradually becomes modern's pursuit
One primary demand of high-quality life.For most people, bleaching is a kind of most simple beauty therapeutic, is had every year in China
The people of up to million meters received dentist's bleaching, may have more people to buy commercial product and attempt oneself progress tooth drift
It is white.
In practical applications, consulting room Inner bleaching is usually that the hydrogenperoxide steam generator of higher concentration is directly used to float as oxidation
White dose, while introducing the decomposition that the means such as illumination, ultrasound accelerate hydrogen peroxide.Home teeth bleaching gel is all usually then with mistake
Aoxidize active oxide material of the urea as bleaching gel.Urea peroxide (carbamide peroxide, CP) is that tooth whitening makes
With a kind of most commonly used preparation.10% CP is home bleaching common drug, and CP can be analyzed to 6.4% urea and 3.6%
Hydrogen peroxide (HP), HP is decomposed into water, oxygen and superoxide radical HO-, the pigment molecular hair of the free radical and tooth
Raw oxidation reaction.The urea of CP release can be improved the pH value in oral cavity and pallet, mitigate the side effect of bleaching agent in alkalinity.Urine
Element also has anti-caries effect, can treat root dental caries and improve oral hygiene.Clinically caused adverse reaction is smaller by CP, and compares HP
Stablize.It is all very active always about its research in tooth whitening field in view of these advantages of CP.
Urea peroxide had both had good stability, convenient for saving, while under certain condition again can be with certain speed
Degree release generates hydrogen peroxide molecule, realizes the bleaching of tooth.But the above method is during bleaching dental surface,
" bleaching " and simultaneous to enamel and dentine, i.e., bleaching agent can destroy having in enamel and dentine simultaneously
Machine object, causes injury of teeth.When carrying out vital pulp tooth bleaching, since bleaching agent overflows, what is most possibly contacted is gum.Largely
Research shows that: the hydrogen peroxide that bleaching agent generates has toxicity to people's gum layer fibrocyte.And excessive hydrogen peroxide is also
Mucous membrane of mouth, throat mucous membrane can be stimulated, possible swallow can also stimulate stomach lining, cause alimentary canal tissue damage.
Most-often used in the family be exactly using whitening toothpaste to tooth carry out whitening, and the principle of whitening toothpaste be
The bleaching species such as urea peroxide are added in toothpaste to bleach tooth.The phase of the bleaching principle of whitening toothpaste and bleaching gel
Together, it and effectively avoids and directly uses bleaching agent damage caused by tooth, gum and oral cavity.But usual formulation of tooth-paste
In some common raw materials, such as have the bio-vitric substance of good dental tissue repairing ability, cannot be very with urea peroxide
Compatibility well, they can accelerate the oxidation of urea peroxide itself, and the especially moisture in toothpaste is easier that oxidation reaction is promoted to accelerate
Active oxygen is released, thus the problem of losing the whitening effect to tooth, the tube expansion of toothpaste and preparation is caused to isolate.Therefore, very
It is necessary to develop the preparation method for having the whitening reparation adjuvant of injury of teeth repair function, toothpaste beauty can not weakened
On the basis of white effect, the tube expansion of toothpaste is effectively prevented, while playing the technology for repairing dental tissue.
Summary of the invention
The primary purpose of the present invention is that the shortcomings that overcoming the prior art and deficiency, prevent whitening agent urea peroxide and biology
Activity glass class repair materials occur chemical reaction and inactivate, and bioactivity glass is avoided to react and cause with urea peroxide
Toothpaste tube expansion provides a kind of tooth whitening reparation adjuvant for having injury of teeth repair function.
Another object of the present invention is to provide the preparation methods that the tooth whitening repairs adjuvant.
It is a further object of the present invention to provide the applications that the tooth whitening repairs adjuvant.
The purpose of the invention is achieved by the following technical solution:
A kind of tooth whitening reparation adjuvant, comprising: encapsulated bioactivity glass and urea peroxide.The capsule metaplasia
Object activity glass is that water-soluble macromolecule formation film wraps up bioactivity glass wherein.
Water-soluble macromolecule and bioactivity glass in the encapsulated bioactivity glass preferably press quality
It is matched than 1:1~3:1.
The encapsulated bioactivity glass is preferably prepared by reverse microemulsion process.
The water-soluble macromolecule is preferably Cypres, alginic acid and its soluble derivative, modified fibre
Dimension element, modification of chitosan.
The Cypres can be one of native starch, natural plant gum, animal glue (casein), chitin etc.
Or at least two.
The modified cellulose can be carboxymethyl cellulose, methylcellulose, hydroxypropyl methyl cellulose, ethoxy
One of cellulose etc. or at least two.
The modification of chitosan can be carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, chitosan quaternary ammonium salt,
One of chitosan lactate, glutamate, sulfated chitosan, hyaluronic acid-like chitosan etc. or at least two
Kind.
The bioactivity glass refers to Si oxide as its main component and the energy when reacting with physiological solution
Enough unorganic glass substances being bonded with growing tissue.For example, bioactivity glass of the invention is a kind of in vitro when being placed on
The glass composition of hydroxyl carbonatoapatite layer will be formed in simulated body fluid.Bioactivity glass of the present invention is also biofacies
Hold, so that it is in vivo, such as irresistible adverse immune is not excited to react in the oral cavity.
The bioactivity glass is that those skilled in the art have been well known, containing K, Na, Sr, Mg, Mn, Fe, Si,
The bioactivity glass of the inorganic actives ion such as Ca, Ag；For example, bioactive glass powder.
The tooth whitening repairs the preparation method of adjuvant, includes the following steps:
(1) it prepares mixed solution: dissolving water-soluble macromolecule and obtain water-soluble Polymer Solution；Then it will give birth to
Object activity glass is scattered in the water-soluble Polymer Solution, and ultrasound removes bubble removing, obtains mixed solution；
(2) it prepares encapsulated bioactivity glass: being based on the mixed solution of step (1), prepared by reverse microemulsion process
Encapsulated bioactivity glass is obtained, is cleaned, it is dry；
(3) encapsulated bioactivity glass made from step (2) is uniformly mixed with a certain amount of urea peroxide to get institute
The tooth whitening stated repairs adjuvant.
Preferably 1:1~3:1 matches in mass ratio for water-soluble macromolecule described in step (1) and bioactivity glass
Than；Further preferably 1.5:1.
Water-soluble Polymer Solution, mixed solution described in step (1) are preferably prepared at 1~4 DEG C.
Reverse microemulsion process described in step (2) is preferably realized by spray-dried instrument, using atomizer by step (1)
Mixed solution spray into oily phase.
Drying described in step (2) is preferably freeze-dried.
The tooth whitening repairs the application of adjuvant, is added in the whitening teeth object in oral cavity.
The object that cleans one's teeth includes toothpaste, chewing gum, embrocates tooth powder, tooth patch, bleaching gel etc..
The application method specifically: the pH value for the object that cleans one's teeth is adjusted to 6.4~7 by pH adjusting agent, it will be described
Tooth whitening is repaired adjuvant and is added in the object that cleans one's teeth, and stirs evenly.
The pH adjusting agent is preferably sodium citrate.
The tooth whitening repairs the additive amount of adjuvant preferably by the encapsulated bioactivity glass in the object that cleans one's teeth
In mass fraction be 3%~10% proportion.
The present invention has the following advantages and effects with respect to the prior art:
The present invention passes through the slow of encapsulated bioactivity glass (water-soluble polymeric membrane/bio-vitric active microsphere)
It releases function and reaches relatively better Dental Erosion effect；Avoid urea peroxide and biology living by water-soluble macromolecule coating
Property glass directly contact and occur chemically react and inactivate, also effectively prevent the tube expansion of toothpaste, extend whitening toothpaste
Shelf-life.Meanwhile in use, water-soluble macromolecule coating is met water and is disintegrated, and is sustained bioactive glass
Ingredient effectively plays the effect of dental tissue is repaired；On the basis of not weakening toothpaste whitening function, reach reparation set of teeth
The purpose knitted.
Meanwhile the advantage that this method has raw material from a wealth of sources, low in cost, easy to operate, be conducive to industrial metaplasia
It produces.
Detailed description of the invention
Fig. 1 is the bioactivity glass of embodiment 1 and the scanning electron microscope (SEM) photograph of encapsulated bioactivity glass.
Fig. 2 is the effect photo figure of 6 whitening effect of embodiment test；Wherein, left side is control group, and right side is experimental group.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited
In this.
The preparation of 1 whitening of embodiment reparation adjuvant
1. water-soluble polymeric membrane/bioactivity glass mixed solution preparation (by taking chitosan as an example)
Chitosan powder is dissolved in 1% acetic acid solution, the chitosan solution that concentration is 2%~5% is configured to, to shell
After glycan is uniformly dissolved, by bio-vitric according to m (bio-vitric): m (chitosan)=1:1~3:1 ratio is dissolved in chitosan
In solution, obtained chitosan/bio-vitric mixed solution ultrasound is removed into bubble removing, 4 DEG C of preservations are spare.
2. reverse microemulsion process prepares encapsulated bioactivity glass
The chitosan prepared in above-mentioned steps 1/bio-vitric mixed solution is prepared into microballoon using spray-dried instrument, wherein
Actual conditions are as follows: 220 DEG C of inlet temperature, 130 DEG C of outlet temperature, admission pressure 0.3MPa, air inlet is than 90%.Then it will prepare
Encapsulated bioactivity glass be dried in vacuo at normal temperature, it is spare.
3. the preparation of whitening reparation adjuvant
The encapsulated bioactivity glass that step 2 is obtained is mixed with a certain amount of urea peroxide to get the whitening
Repair adjuvant.
By the preparation method, the encapsulated bioactivity glass of each group in table 1 is prepared by formula:
Table 1
The morphological observation of the encapsulated bioactivity glass of embodiment 2
Encapsulated -1 surface topography of bioactivity glass is observed using Hitachi, Ltd's S-570 scanning electron microscope, using ion
Coating method is sprayed in the uniform metal spraying of sample surfaces, is subsequently placed on Electronic Speculum objective table and is observed.Technological parameter are as follows: voltage accelerates pressurization
20kV, electric current 0.5mA, 10 °~20 ° of incidence angle；As a result as shown in Figure 1.
It will be seen from figure 1 that irregular granule-morphology is presented in bioactivity glass before wrapping up chitosan film；Packet
After having wrapped up in chitosan film, the spherical morphology of rule is presented, it is regular.
The measurement of 3 colloidal stability of embodiment
To component difference clean one's teeth colloidal compositions carry out colloidal stability measurement.
Control group selects ordinary toothpaste on the market；Experimental group 1 is to add the urea peroxide of mass ratio 1% in ordinary toothpaste
With the bioactivity glass (CaOP of mass ratio 3%2O5·Na2O·SiO2)；Experimental group 2 is that ordinary toothpaste adds mass ratio
Encapsulated bioactivity glass -1 made from 1% urea peroxide and the embodiment 1 of mass ratio 3%；By control group, experimental group 1,
The colloid that experimental group 2 obtains is encapsulated into band, the volume that gas generates in hermetic bag is detected, according to different intervals
Observe it is gas generated (using different number+indicate), the results are shown in Table 2:
Table 2
As shown in Table 2, in the case where handling same time interval, encapsulated bioactivity glass of the invention it is gas generated
Well below experimental group 1, it can be seen that be added to the glue of the colloidal compositions that clean one's teeth of encapsulated bioactivity glass of the invention
Body stability is increased substantially；The tube expansion for effectively preventing toothpaste extends the shelf-life of whitening toothpaste.
The measurement of 4 colloidal stability of embodiment
To component difference clean one's teeth colloidal compositions carry out colloidal stability measurement.
Control group selects ordinary toothpaste on the market；Experimental group 1 is to add the urea peroxide of mass ratio 1% in ordinary toothpaste
With the bioactivity glass (CaOP of mass ratio 3%2O5·K2O·SiO2)；Experimental group 2 is that ordinary toothpaste adds mass ratio 1%
Urea peroxide and mass ratio 3% embodiment 1 made from encapsulated bioactivity glass -2.Control group, experimental group 1, experiment
2 obtained colloids of group are encapsulated into band, according to different intervals observation it is gas generated (using different number+table
Show), the results are shown in Table 3:
Table 3
As shown in Table 3, in the case where handling same time interval, encapsulated bioactivity glass of the invention it is gas generated
Well below experimental group 1, it can be seen that be added to the glue of the colloidal compositions that clean one's teeth of encapsulated bioactivity glass of the invention
Body stability is increased substantially；The tube expansion for effectively preventing toothpaste extends the shelf-life of whitening toothpaste.
The measurement of 5 colloidal stability of embodiment
To component difference clean one's teeth colloidal compositions carry out colloidal stability measurement.Control group selects common tooth on the market
Cream；Experimental group 1 is that the bioactivity glass (CaO of the urea peroxide and mass ratio 3% of mass ratio 1% is added in ordinary toothpaste
P2O5·K2O·SiO2)；Experimental group 2 is that ordinary toothpaste adds the urea peroxide of mass ratio 1% and the embodiment 1 of mass ratio 3%
Encapsulated bioactivity glass -3 obtained.Control group, experimental group 1,2 colloid of experimental group are encapsulated into band, according to not
With interval time observation it is gas generated (using different number+indicate), the results are shown in Table 4:
Table 4
As shown in Table 4, in the case where handling same time interval, encapsulated bioactivity glass of the invention it is gas generated
Well below experimental group 1, it can be seen that be added to the glue of the colloidal compositions that clean one's teeth of encapsulated bioactivity glass of the invention
Body stability is increased substantially；The tube expansion for effectively preventing toothpaste extends the shelf-life of whitening toothpaste.
The test of 6 whitening effect of embodiment
To component difference clean one's teeth colloidal compositions carry out whitening effect test.Control group selects ordinary toothpaste on the market；
Experimental group is that encapsulated biology made from the urea peroxide of mass ratio 1% and the embodiment 1 of mass ratio 3% is added in ordinary toothpaste
Activity glass -1.Baurodont is selected to be tested as whitening sample.It is required that every group uses same volume toothpaste or colloid group every time
It closes object to be placed on toothbrush, rapidly and uniformly brushes the full flank of tooth, and brush teeth repeatedly tooth dyeing part 2 minutes, once in the morning and once at night.Examination
Test terminate statistical result as shown in table 5 (whitening effect using different number+indicate):
Table 5
As a result as shown in Fig. 2 and table 5, it is added to the whitening effect of the experimental group of encapsulated bioactivity glass -1 of the invention
Fruit has considerable degree of raising compared with control group；Wherein, the left side of Fig. 2 is control group, and color whiteness is poor, and right side is experimental group, color
Damp whiteness is obviously more preferable.
The test of 7 whitening effect of embodiment
To component difference clean one's teeth colloidal compositions carry out whitening effect test.Control group selects ordinary toothpaste on the market；
Experimental group is that encapsulated biology made from the urea peroxide of mass ratio 1% and the embodiment 4 of mass ratio 3% is added in ordinary toothpaste
Activity glass -2.Baurodont is selected to be tested as whitening sample.It is required that every group uses same volume toothpaste or colloid group every time
It closes object to be placed on toothbrush, rapidly and uniformly brushes the full flank of tooth, and brush teeth repeatedly tooth dyeing part 2 minutes, once in the morning and once at night.Examination
Test terminate statistical result as shown in table 6 (whitening effect using different number+indicate):
Table 6
The results are shown in Table 6, and the whitening effect for being added to the experimental group of encapsulated bioactivity glass of the invention is more right
It increases significantly according to group.
8 cell toxicity test of embodiment
Cytotoxicity examination is carried out using the agar diffusion method in YY/T0127.9-2014 oral cavity medical apparatus biological assessment
It tests, to the cell of the colloidal compositions (i.e. the composition of encapsulated bioactivity glass and urea peroxide in table 7) of different component
Toxicity is evaluated, and is configured to 2.5 × 10 using L929 cell strain (l cell) and grown cultures liquid5Cell is outstanding
Liquid is drawn in 10mL addition culture dish and is incubated for for 24 hours.Then culture solution is sucked out, brand-new agar 10mL is added, it is solidifying to agar medium
After Gu, neutral red staining solution is added and saves 30min, absorbs excess stain liquid.By colloidal compositions and control group (with grown cultures
Liquid is negative control group, and the filter membrane that phenol solution is impregnated is positive controls) uniformly it is applied on filter membrane, it is placed in culture dish.5%
Carbon dioxide, 37 DEG C of constant temperature are protected from light culture for 24 hours.With the colour fading region around inverted microscope observation experiment and control material,
The results are shown in Table 7.
7 colloidal compositions agar diffusion method experimental result of table
The results are shown in Table 7, the encapsulated bioactivity glass of different component of the invention and the cooperation of urea peroxide, with
Control sample is compared, and slight cytotoxicity is shown；And simple urea peroxide then shows moderate cytotoxicity；As a result it says
The bright encapsulated bioactivity glass of addition helps to improve the cytotoxicity of urea peroxide.
Above embodiments prove that the present invention not only prevents whitening agent urea peroxide and bioactivity glass class repair materials from sending out
It is biochemical reaction and inactivate, also while not weakening toothpaste whitening function, the tooth for effectively realizing bioactivity glass is repaired
Multiple effect；And also reduce the cytotoxicity of urea peroxide；The tube expansion for effectively preventing toothpaste, extends whitening toothpaste
Shelf-life has a good application prospect.Meanwhile after complex capsule bioactivity glass, than urea peroxide table is used alone
Lower cytotoxicity is revealed.So the implementation of the invention will be helpful to the development of toothpaste additive；Improve tooth beauty
The white technological progress with the field of reparation.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (10)
1. a kind of tooth whitening repairs adjuvant, it is characterised in that:
It includes encapsulated bioactivity glass and urea peroxide that the tooth whitening, which repairs adjuvant, and the encapsulated biology is living
Property glass be water-soluble macromolecule formed film by bioactivity glass wrap up wherein.
2. tooth whitening according to claim 1 repairs adjuvant, it is characterised in that:
Water-soluble macromolecule and bioactivity glass 1:1~3 in mass ratio in the encapsulated bioactivity glass:
1 proportion.
3. the preparation method that the described in any item tooth whitenings of claims 1 or 2 repair adjuvant, which is characterized in that including as follows
Step:
(1) it prepares mixed solution: dissolving water-soluble macromolecule and obtain water-soluble Polymer Solution；Then biology is living
For property glass dispersible in the water-soluble Polymer Solution, ultrasound removes bubble removing, obtains mixed solution；
(2) it prepares encapsulated bioactivity glass: being based on the mixed solution of step (1), be prepared by reverse microemulsion process
Encapsulated bioactivity glass cleans, dry；
(3) encapsulated bioactivity glass made from step (2) is uniformly mixed with a certain amount of urea peroxide to get described
Tooth whitening repairs adjuvant.
4. the preparation method that the tooth whitening according to claim 3 repairs adjuvant, it is characterised in that:
Water-soluble macromolecule described in step (1) and bioactivity glass 1:1~3:1 in mass ratio proportion；
Water-soluble Polymer Solution, mixed solution described in step (1) are prepared at 1~4 DEG C.
5. the preparation method that the tooth whitening according to claim 3 repairs adjuvant, it is characterised in that:
The water-soluble macromolecule is Cypres, alginic acid and its soluble derivative, modified cellulose, modification
Chitosan.
6. the preparation method that the tooth whitening according to claim 5 repairs adjuvant, it is characterised in that:
The Cypres can be one of native starch, natural plant gum, animal glue, chitin or at least two；
The modified cellulose can be carboxymethyl cellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxy ethyl fiber
One of element or at least two；
It is poly- that the modification of chitosan can be carboxymethyl chitosan, chitosan oligosaccharide, chitosan hydrochloride, chitosan quaternary ammonium salt, shell
One of saccharolactic acid salt, glutamate, sulfated chitosan, hyaluronic acid-like chitosan or at least two.
7. tooth whitening described in repairs the application of adjuvant, it is characterised in that:
The application is to be added in the whitening teeth object in oral cavity.
8. the application that tooth whitening according to claim 7 repairs adjuvant, it is characterised in that:
The object that cleans one's teeth includes toothpaste, chewing gum, embrocates tooth powder, tooth patch, bleaching gel.
9. the application that tooth whitening according to claim 7 repairs adjuvant, it is characterised in that:
The application method specifically: the pH value for the object that cleans one's teeth is adjusted to 6.4~7 by pH adjusting agent, by the tooth
Whitening is repaired adjuvant and is added in the object that cleans one's teeth, and stirs evenly.
10. the application that tooth whitening according to claim 7 repairs adjuvant, it is characterised in that:
The additive amount of the tooth whitening reparation adjuvant is by the encapsulated bioactivity glass in the object that cleans one's teeth
Mass fraction be 3%~10% proportion.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN115463041A (en) * | 2022-09-28 | 2022-12-13 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste with cold light whitening effect and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100086497A1 (en) * | 2008-10-08 | 2010-04-08 | Biofilm Limited | Tooth remineralisation |
| CN103118651A (en) * | 2009-04-27 | 2013-05-22 | 普雷米尔牙科产品公司 | Microencapsulated compositions and methods for tissue mineralization |
| CN104207960A (en) * | 2013-06-05 | 2014-12-17 | 上海诺帮生物科技有限公司 | Toothpaste containing bioactive glass/chitosan |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
| CN104870179A (en) * | 2012-09-14 | 2015-08-26 | 第一牙科产品公司 | Buffered microencapsulated compositions and methods |
-
2018
- 2018-03-20 CN CN201810229333.XA patent/CN110302067B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100086497A1 (en) * | 2008-10-08 | 2010-04-08 | Biofilm Limited | Tooth remineralisation |
| CN103118651A (en) * | 2009-04-27 | 2013-05-22 | 普雷米尔牙科产品公司 | Microencapsulated compositions and methods for tissue mineralization |
| CN104870179A (en) * | 2012-09-14 | 2015-08-26 | 第一牙科产品公司 | Buffered microencapsulated compositions and methods |
| CN104207960A (en) * | 2013-06-05 | 2014-12-17 | 上海诺帮生物科技有限公司 | Toothpaste containing bioactive glass/chitosan |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN115463041A (en) * | 2022-09-28 | 2022-12-13 | 重庆登康口腔护理用品股份有限公司 | Anti-allergy toothpaste with cold light whitening effect and preparation method thereof |
| CN115463041B (en) * | 2022-09-28 | 2023-10-20 | 重庆登康口腔护理用品股份有限公司 | Anti-sensitivity toothpaste with cold light whitening effect and preparation method thereof |
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