CN102531385A - Bioactive glass and preparation method thereof - Google Patents
Bioactive glass and preparation method thereof Download PDFInfo
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- CN102531385A CN102531385A CN2012100131282A CN201210013128A CN102531385A CN 102531385 A CN102531385 A CN 102531385A CN 2012100131282 A CN2012100131282 A CN 2012100131282A CN 201210013128 A CN201210013128 A CN 201210013128A CN 102531385 A CN102531385 A CN 102531385A
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Abstract
The invention provides a bioactive glass and a preparation method thereof. The bioactive glass is characterized by being prepared from 51-53wt% of silicon dioxide, 21-24wt% of sodium oxide, 18-21wt% of calcium oxide and 3-5wt% of phosphorus pentoxide. The bioactive glass disclosed by the invention can be subjected to repeated thermal treatment and is not crystallized, and can be molded to be different shapes so as to be suitable for plastic surgeries, such as a bone transplantation operation and a bone defect filling operation.
Description
Technical field
The present invention relates to bioactivity glass and preparation method thereof.Described bioactivity glass can be used for filling bone defects.
Background technology
The surface of bioactivity glass can generate active coating to play the effect of bonding medical device and tissue.Different with other biological active materials is that the chemical reaction rate of bioactivity glass can be controlled through controlling its composition at an easy rate.Therefore, bioactivity glass has the good clinical application prospect, and has been used for substituting the facial tissue that damages after the wound, substitutes intratympanic ossiculum (otosteon), and is used to fill up the bone defective in the operation.
Traditional bioactivity glass is by SiO
2, Na
2O, CaO and P
2O
5Form, it can not be repeated heat treated, thereby because the multiple heat treated can cause crystallization to destroy its biological activity.Brought very big problem for thus the processing of such bioactivity glass device, they can only perhaps obtain final shape through in type glass is ground through mould molding in the production process of glass.Owing to have only amorphous bio-vitric just to have good biological activity; And bioactivity glass itself just is easy to be separated; Therefore through prior art be difficult to obtain a kind of in repeating heat-treatment process non crystallized bio-vitric, only if the additives such as oxide compound that add magnesium, boron are to keep its biological activity.
Summary of the invention
First purpose of the present invention provides a kind of bioactivity glass, and the thermal treatment and non-crystallizable and can fashion into different shapes repeatedly of described bioactivity glass is suitable for plastic surgery operations, like bone grafting operation and filling bone defects.
Second purpose of the present invention provides the fusion preparation method of above-mentioned bioactivity glass.
The 3rd purpose of the present invention provides the implantable medical device that above-mentioned bioactivity glass is processed.
The invention provides a kind of bioactivity glass, it is characterized in that, by silicon-dioxide (SiO
2) 51～53wt%, sodium oxide (Na
2O) 21～24wt%, quicklime (CaO) 18～21wt% and Vanadium Pentoxide in FLAKES (P
2O
5) 3～5wt% composition.
The present invention also provides the fusion preparation method of above-mentioned bioactivity glass, it is characterized in that, concrete steps are:
The first step: with silicon-dioxide (SiO
2) 151～157 weight parts, calcium phosphate dibasic dihydrate (CaHPO
42H
2O) 21.23～35.38 weight parts, lime carbonate (CaCO
3) 80.51～93.92 weight parts and yellow soda ash (Na
2CO
3) mixing of 106.69～121.93 weight parts;
Second step: with gained mixture heating up to 1350～1450 ℃ and normal pressure insulation 3～5 hours;
The 3rd step: cool to room temperature keeps more than 12 hours to obtain solid glass;
The 4th step: the solid glass of gained is ground into piece;
The 5th step: be heated to once more 1350～1450 ℃ and normal pressure insulation 3～5 hours to obtain the remollescent bioactive glass compositions;
The 6th step: the bioactive glass compositions of gained is molded as required shape and cool to room temperature.
The implantable medical device that the present invention also provides above-mentioned bioactivity glass to process.The bioactivity glass of gained of the present invention can be processed the apparatus of various needs through traditional method.
Advantage of the present invention comprises:
1, the bioactivity glass of gained of the present invention thermal treatment and non-crystallizable and can fashion into different shapes repeatedly is suitable for plastic surgery operations, like bone grafting operation and filling bone defects;
2, the bioactivity glass of gained of the present invention is suitable for making particles of different sizes.
Description of drawings
Fig. 1 be product and the traditional bioactivity glass of embodiment 1, embodiment 2 gained when in SBF, soaking 0,6,27,48,73,124,171,248 and 336 hour for 37 ℃, soak time and silicon ion burst size graph of a relation;
Fig. 2 be product and the traditional bioactivity glass of embodiment 1, embodiment 2 gained when in SBF, soaking 0,6,27,48,73,124,171,248 and 336 hour for 37 ℃, soak time and phosphonium ion deposition graph of a relation;
Fig. 3 be product and the traditional bioactivity glass of embodiment 1, embodiment 2 gained when in SBF, soaking 0,6,27,48,73,124,171,248 and 336 hour for 37 ℃, soak time and calcium ion deposition magnitude relation figure.
Embodiment
Specify the present invention below in conjunction with embodiment.
Embodiment 1
(1) with raw material SiO
2154g, CaHPO
42H
2O 28.30g, CaCO
393.92g and Na
2CO
3116.85g mix;
(2) made carbonate reaction wherein generate corresponding oxide compound in three hours the mixture heating up to 1360 of gained ℃ and normal pressure insulation;
(3) melts of gained is cooled to 520 ℃ and be incubated 2 hours, further cool to room temperature kept 12 hours then;
(4) solid glass with gained is ground into the fritter of particle diameter less than 5000 μ m;
(5) glass block after will pulverizing was heated to 1360 ℃ and normal pressure insulation three hours once more;
(6) the remollescent bioactive glass compositions of gained is cast in the mould, and is cooled to 520 ℃, is incubated 2 hours, and further then cool to room temperature kept 12 hours, obtained 500g by SiO
252wt%, Na
2O 23wt%, CaO 21wt% and P
2O
5The bioactivity glass that 4wt% forms.In the preparation process of above-mentioned bioactivity glass, need not use shielding gas.
(7) bioactivity glass with gained is ground into particle;
(8) particle with gained carries out the heat shock processing with the acetylene flame, in non-oxidizing atmosphere, sinters piece under 500 ℃ then.
(1) with raw material SiO
2154g, CaHPO
42H
2O 35.38g, CaCO
384.98g and Na
2CO
3121.93g mix;
(2) made carbonate reaction wherein generate corresponding oxide compound in 2.5 hours the mixture heating up to 1390 of gained ℃ and normal pressure insulation;
(3) melts of gained is cooled to 520 ℃ and be incubated 3 hours, further cool to room temperature kept 12 hours then;
(4) solid glass with gained is ground into the fritter of particle diameter less than 5000 μ m;
(5) glass block after will pulverizing was heated to 1390 ℃ and normal pressure insulation 2.5 hours once more;
(6) the remollescent bioactive glass compositions of gained is cast in the mould, and is cooled to 520 ℃, is incubated 3 hours, and further then cool to room temperature kept 12 hours, obtained 500g by SiO
252wt%, Na
2O 24wt%, CaO 19wt% and P
2O
5The bioactivity glass that 5wt% forms.In the preparation process of above-mentioned bioactivity glass, need not use shielding gas.
(7) bioactivity glass with gained is ground into particle;
(8) particle with gained carries out the heat shock processing with the acetylene flame, in non-oxidizing atmosphere, sinters piece under 500 ℃ then.
Accompanying drawing 1,2 and 3 has provided the solubility property of two kinds of bioactivity glass of embodiment 1 and embodiment 2 gained.The particle diameter of used bioactive glass particle is the particle of 1～45 μ m all less than 400 μ m comprising particle diameter.Point among the figure on the corresponding curve of every kind of bioactivity glass is the MVs of three groups of experiments.Provided among the figure when in simulated body fluid (SBF), soaking 0,6,27,48,73,124,171,248 and 336 hour under 37 ℃, through phosphorus, the deposition of calcium and the burst size of silicon ion among the SBF of ultraviolet-visible colorimetric analysis (UV-VIS colorimetric analysis) measurement.Traditional bioactivity glass among Fig. 1,2 and 3 is the NovaBone product that NovaBone Products company produces.The deposition of phosphorus, calcium is the index that calcium phosphate well known in the art forms in the SBF Soak Test, can be used for indicating biological activity.SBF composition such as following table:
Accompanying drawing 1,2 and 3 shows that the repetition heat treated does not influence the biological activity of glass of the present invention, just means that also the repetition heat treated can't cause crystallization, because crystallization meeting known in this field destroys the biological activity of glass.
Method of the present invention has numerous embodiments, and the present invention only can provide limited embodiment.Under the prerequisite that does not break away from spirit of the present invention, exist other embodiment will be apparent to those skilled in the art.Therefore, embodiment provided by the present invention only is used to technology contents of the present invention is described, and can not be understood that the restriction to protection domain of the present invention.
Claims (3)
1. a bioactivity glass is characterized in that, is made up of silicon-dioxide 51～53wt%, sodium oxide 21～24wt%, quicklime 18～21wt% and Vanadium Pentoxide in FLAKES 3～5wt%.
2. the fusion preparation method of the described bioactivity glass of claim 1 is characterized in that, concrete steps are:
The first step: silica 1 51～157 weight parts, calcium phosphate dibasic dihydrate 21.23～35.38 weight parts, lime carbonate 80.51～93.92 weight parts and yellow soda ash 106.69～121.93 weight parts are mixed;
Second step: with gained mixture heating up to 1350～1450 ℃ and normal pressure insulation 3～5 hours;
The 3rd step: cool to room temperature keeps more than 12 hours to obtain solid glass;
The 4th step: the solid glass of gained is ground into piece;
The 5th step: be heated to once more 1350～1450 ℃ and normal pressure insulation 3～5 hours to obtain the remollescent bioactive glass compositions;
The 6th step: the bioactive glass compositions of gained is molded as required shape and cool to room temperature.
3. the implantable medical device processed of the described bioactivity glass of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100131282A CN102531385A (en) | 2012-01-17 | 2012-01-17 | Bioactive glass and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100131282A CN102531385A (en) | 2012-01-17 | 2012-01-17 | Bioactive glass and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN102531385A true CN102531385A (en) | 2012-07-04 |
Family
ID=46339587
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|---|---|---|---|
| CN2012100131282A Pending CN102531385A (en) | 2012-01-17 | 2012-01-17 | Bioactive glass and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103848566A (en) * | 2012-12-04 | 2014-06-11 | 董毅翔 | Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
| CN104743886A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Bioactive glass ceramic and preparation method thereof |
| CN104829128A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Transparent biological glass and preparation method thereof |
| CN107129157A (en) * | 2017-05-08 | 2017-09-05 | 浙江理工大学 | A kind of preparation method of three-dimensional porous bioactivity glass |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996000536A1 (en) * | 1994-06-30 | 1996-01-11 | Orthovita, Inc. | Bioactive granules for bone tissue formation |
| CN1361076A (en) * | 2002-01-18 | 2002-07-31 | 中国科学院上海硅酸盐研究所 | Nanometer level bioactive glass powder material and its prepn |
| EP1405647A1 (en) * | 2002-10-03 | 2004-04-07 | Heimo Ylänen | Bioactive glass composition |
| WO2009019323A2 (en) * | 2007-08-03 | 2009-02-12 | Vivoxid Oy | Use of bioactive glass |
| WO2010122019A1 (en) * | 2009-04-23 | 2010-10-28 | Vivoxid Oy | Resorbable and biocompatible fibre glass compositions and their uses |
-
2012
- 2012-01-17 CN CN2012100131282A patent/CN102531385A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996000536A1 (en) * | 1994-06-30 | 1996-01-11 | Orthovita, Inc. | Bioactive granules for bone tissue formation |
| CN1361076A (en) * | 2002-01-18 | 2002-07-31 | 中国科学院上海硅酸盐研究所 | Nanometer level bioactive glass powder material and its prepn |
| EP1405647A1 (en) * | 2002-10-03 | 2004-04-07 | Heimo Ylänen | Bioactive glass composition |
| WO2009019323A2 (en) * | 2007-08-03 | 2009-02-12 | Vivoxid Oy | Use of bioactive glass |
| WO2010122019A1 (en) * | 2009-04-23 | 2010-10-28 | Vivoxid Oy | Resorbable and biocompatible fibre glass compositions and their uses |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103848566A (en) * | 2012-12-04 | 2014-06-11 | 董毅翔 | Method for preparing micron-sized biological activity glass and application thereof in departments of orthopedics and dentistry |
| CN104586636A (en) * | 2015-02-03 | 2015-05-06 | 徐阳波 | Tooth-cleaning composition for whitening teeth and repairing wounds |
| CN104743886A (en) * | 2015-03-31 | 2015-07-01 | 苏州维泰生物技术有限公司 | Bioactive glass ceramic and preparation method thereof |
| CN104829128A (en) * | 2015-03-31 | 2015-08-12 | 苏州维泰生物技术有限公司 | Transparent biological glass and preparation method thereof |
| CN107129157A (en) * | 2017-05-08 | 2017-09-05 | 浙江理工大学 | A kind of preparation method of three-dimensional porous bioactivity glass |
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Application publication date: 20120704 |