CN106117569A - A kind of marine red alga hydrogel and preparation method thereof - Google Patents

A kind of marine red alga hydrogel and preparation method thereof Download PDF

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Publication number
CN106117569A
CN106117569A CN201610466876.4A CN201610466876A CN106117569A CN 106117569 A CN106117569 A CN 106117569A CN 201610466876 A CN201610466876 A CN 201610466876A CN 106117569 A CN106117569 A CN 106117569A
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hydrogel
red alga
marine red
marine
solvent
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CN201610466876.4A
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金海明
李洪波
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QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd
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QINGDAO ZHONGTENG BIOTECHNOLOGY Co Ltd
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Priority to CN201610466876.4A priority Critical patent/CN106117569A/en
Publication of CN106117569A publication Critical patent/CN106117569A/en
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
    • C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend

Abstract

The invention belongs to new polymeric materials technical field, relate to a kind of hydrogel and preparation method thereof.A kind of marine red alga hydrogel, including following components in percentage by weight: marine red alga glue 0.25 20%, thickening agent 0.4 20%, adhesive 0.1 20%, antibacterial 0.001 20%, solvent 30 99.5%.Compared with prior art, aerogel dressing transparency that the present invention obtains is high, pliability is good, extensive without adding poisonous and harmful cross-linking agent, raw material sources, nontoxic non-stimulated, has good practical value.

Description

A kind of marine red alga hydrogel and preparation method thereof
Technical field
The invention belongs to new polymeric materials technical field, relate to a kind of hydrogel and preparation method thereof.
Background technology
Hydrogel application widely, as can be made into hydrogel facial film, eye sticker, defervescence plaster used or wound dressing etc., Within 1962, doctor Winter confirms in animal (pig) is tested first, and under airtight moist environment, speed of wound healing ratio is sudden and violent It is exposed to air drying wound surface fast again, thus proposes wound surface moisturizing environment healing new ideas.Presently commercially available hydrogel In, for ensureing gel strength, the modes using crosslinking process raw material more, and the cross-linking agent used such as epoxychloropropane, ethylene glycol Diglycidyl ether, glutaraldehyde, allyl glycidyl ether, Glycerin triglycidyl ether or glycerol three-glycidyl Ether etc., as reaction not exclusively maybe can not completely remove, then may produce impact to the healthy of user.So, exploitation is without crosslinking The hydrogel product of agent is the inexorable trend of development.
Summary of the invention
It is an object of the invention to make up defect present in prior art, it is provided that one need not cross-link and can be formed the most by force Hydrogel of degree and preparation method thereof.
To achieve these goals, the technical solution used in the present invention is: a kind of marine red alga hydrogel, including following The component of percentage by weight: marine red alga glue 0.25-20%, thickening agent 0.4-20%, adhesive 0.1-20%, antibacterial 0.001- 20%, solvent 30-99.5%.
Any one in Furcellaran, fork Furcellaran, agar or carrageenan of marine red alga glue, or two or more material The mixture of composition.
Carrageenan, preferably K-type (Kappa) and I type (Iota) type carrageenan.
Thickening agent is in sodium alginate, calcium alginate, potassium alginate, Konjac glucomannan, xanthan gum, PVP The mixture of one or more materials composition.
Adhesive is Mel, Bletilla glucomannan, cyano group acid esters, silicone adhesive, polyacrylate or acid polyethylene ether.
Antibacterial is pentanediol, hexanediol, caprylyl glycol, decanediol, Sensiva SC50, Methylisothiazolinone, poly-ammonia Propyl group biguanide, BIT, chlorphenesin, phenoxyethanol, deoxidation acetic acid, methyl parahydroxybenzoate, para hydroxybenzene Ethyl formate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate, benzalkonium chloride, benzyl alcohol, hexamidine disalt, the bent chlorine in west In ammonium, chlorination ammonium salt, sodium benzoate, potassium sorbate, iodine propilolic alcohol ethyl mephenesin Carbamate, Boulogne bohr, DBNPA Any one.
Solvent is purified water.
The present invention also provides for the preparation method of a kind of marine red alga hydrogel, comprises the following steps:
(1) take thickening agent and adhesive is dissolved in solvent, stir, marine red alga glue is scattered in solvent, makes algae Glue dispersion liquid；
(2) regulation system pH value is to 4.5-8, then heats to 50-100 DEG C, keeps 5-120min, is cooled to 30-80 DEG C, adds Antibacterial also stirs；
(3) pouring mixed solution into mould, under 4～80 ° of C, aging 0.5～6h i.e. obtains marine red alga hydrogel.
Use directly packed by prepared hydrogel after can suitably cutting out, or is soaked in and comprises medicine or activity becomes In the solution divided, the spreading effect caused by concentration difference, by the material absorbing in solution in hydrocolloid, make functional Product, such as facial film, eye sticker or medical dressing etc..
Compared with prior art, the present invention obtains aerogel dressing transparency is high, pliability is good, poisonous have without adding Evil cross-linking agent, raw material sources are extensive, nontoxic non-stimulated, have good practical value.
Detailed description of the invention
The marine red alga hydrogel of example 1 the present embodiment, comprises the raw material components of following percentage by weight: K-type OK a karaoke club Glue 2.2%, sodium alginate 0.8%, Mel 3%, phenoxyethanol 0.6%, purified water 93.4%.
The marine red alga hydrogel of the present embodiment, is prepared from by following steps:
(1) take sodium alginate in proportion and Mel is dissolved in purified water, stir, carrageenan is dispersed in water, make Algin dispersion liquid；
(2) regulation system pH value is to 7.0, then heats to 70 DEG C, keeps 110min, is cooled to 70 DEG C, adds phenoxyethanol also Stir；
(3) pouring mixed solution into mould, under 25 ° of C, aging 2h i.e. obtains marine red alga hydrogel.
The marine red alga hydrogel of embodiment 2 the present embodiment, the raw material components comprising following percentage by weight: pitch red Algin 3.6%, xanthan gum 0.5%, Konjac glucomannan 0.5%, silicone adhesive 2.5%, polyaminopropyl biguanide 0.8%, purified water 92.1%.
The marine red alga hydrogel of the present embodiment, is prepared from by following steps:
(1) take xanthan gum xanthan gum, Konjac glucomannan and silicone adhesive in proportion to be dissolved in purified water, stir, Furcellaran will be pitched It is dispersed in water, makes algin dispersion liquid；
(2) regulation system pH value is to 7.0, then heats to 85 DEG C, keeps 80min, is cooled to 65 DEG C, adds polyaminopropyl biguanide And stir；
(3) pouring mixed solution into mould, under 30 ° of C, aging 1.5h i.e. obtains marine red alga hydrogel.
The marine red alga hydrogel of embodiment 3 the present embodiment, comprises the raw material components of following percentage by weight: agar 1.2%, Furcellaran 2.0%, polyvinylpyrrolidone 1.3%, polyacrylate 2.8%, benzalkonium chloride 1.1%, purified water 91.6%.
The marine red alga hydrogel of the present embodiment, is prepared from by following steps:
(1) take polyvinylpyrrolidone in proportion and polyacrylate is dissolved in purified water, stir, by agar and red algae Glue is dispersed in water, and makes algin dispersion liquid；
(2) regulation system pH value is to 7.0, then heats to 90 DEG C, keeps 50min, is cooled to 60 DEG C, adds benzalkonium chloride and stirs Mix uniformly；
(3) pouring mixed solution into mould, under 32 ° of C, aging 2.5h i.e. obtains marine red alga hydrogel.
The marine red alga hydrogel of embodiment 4 the present embodiment, comprises the raw material components of following percentage by weight: red algae Glue 2.1%, fork Furcellaran 0.8%, calcium alginate 1.5%, cyano group acid esters 3.2%, BIT 1.3%, purified water 91.1%.
The marine red alga hydrogel of the present embodiment, is prepared from by following steps:
(1) take calcium alginate in proportion and cyano group acid esters is dissolved in purified water, stir, fork Furcellaran and Furcellaran are divided Dissipate in water, make algin dispersion liquid；
(2) regulation system pH value is to 7.0, then heats to 80 DEG C, keeps 100min, is cooled to 70 DEG C, adds benzisothiazole Quinoline ketone also stirs；
(3) pouring mixed solution into mould, under 30 ° of C, aging 0.5h i.e. obtains marine red alga hydrogel.

Claims (8)

1. a marine red alga hydrogel, it is characterised in that: include following components in percentage by weight: marine red alga glue 0.25-20%, thickening agent 0.4-20%, adhesive 0.1-20%, antibacterial 0.001-20%, solvent 30-99.5%.
Marine red alga hydrogel the most according to claim 1, it is characterised in that: marine red alga glue is selected from Furcellaran, fork Any one in Furcellaran, agar or carrageenan, or the mixture of two or more material composition.
Marine red alga hydrogel the most according to claim 2, it is characterised in that: carrageenan is K-type or I type carrageenan.
Marine red alga hydrogel the most according to claim 1, it is characterised in that: thickening agent is selected from sodium alginate, Sargassum The mixture of one or more materials composition in acid calcium, potassium alginate, Konjac glucomannan, xanthan gum, PVP.
Marine red alga hydrogel the most according to claim 1, it is characterised in that: adhesive is Mel, Bletilla glucomannan, cyano group Acid esters, silicone adhesive, polyacrylate or acid polyethylene ether.
Marine red alga hydrogel the most according to claim 1, it is characterised in that: antibacterial is pentanediol, hexanediol, pungent Glycol, decanediol, Sensiva SC50, Methylisothiazolinone, polyaminopropyl biguanide, BIT, chlorphenesin, Phenoxyethanol, deoxidation acetic acid, methyl parahydroxybenzoate, ethylparaben, propyl p-hydroxybenzoate, para hydroxybenzene Butyl formate, benzalkonium chloride, benzyl alcohol, hexamidine disalt, cetrimonium chloride, chlorination ammonium salt, sodium benzoate, potassium sorbate, iodine third Any one in alkynol ethyl mephenesin Carbamate, Boulogne bohr, DBNPA.
Marine red alga hydrogel the most according to claim 1, it is characterised in that: solvent is purified water.
8. a preparation method for marine red alga hydrogel, comprises the following steps:
(1) take thickening agent and adhesive is dissolved in solvent, stir, marine red alga glue is scattered in solvent, makes algae Glue dispersion liquid；
(2) regulation system pH value is to 4.5-8, then heats to 50-100 DEG C, keeps 5-120min, is cooled to 30-80 DEG C, adds Antibacterial also stirs；
(3) pouring mixed solution into mould, under 4～80 ° of C, aging 0.5～6h i.e. obtains marine red alga hydrogel.
CN201610466876.4A 2016-06-24 2016-06-24 A kind of marine red alga hydrogel and preparation method thereof Pending CN106117569A (en)

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412838A (en) * 2017-07-28 2017-12-01 威海洁瑞医用制品有限公司 Hydrocolloid and medical application containing vitamin E and 1,2 hexylene glycols and preparation method thereof
CN107868139A (en) * 2017-12-05 2018-04-03 青岛聚大洋藻业集团有限公司 The method that OIT makees bactericide processing algin
CN110623792A (en) * 2019-09-23 2019-12-31 温州医科大学附属第一医院 Medical dressing and preparation method thereof
CN110859701A (en) * 2019-12-02 2020-03-06 广东美贝健药业有限公司 Antibacterial gel antipyretic patch and preparation method thereof
CN111481497A (en) * 2019-01-28 2020-08-04 北京万生人和科技有限公司 Hydrogel
CN112545934A (en) * 2020-12-10 2021-03-26 龙林平 Seabuckthorn fruit extract moisturizing gel and preparation method thereof
CN113456883A (en) * 2021-07-23 2021-10-01 绍兴百立康医疗科技有限公司 Cold compress anti-inflammation gel and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103520767A (en) * 2013-10-28 2014-01-22 山东赛克赛斯药业科技有限公司 Anti-microbial healing-promoting hydrogel dressing and preparation method therefor
CN105188651A (en) * 2013-04-18 2015-12-23 C&Tech株式会社 Composition for hydrogel pack and mask pack using same
CN105456056A (en) * 2014-12-10 2016-04-06 韩佛化妆品株式会社 Hydrogel composition for masking pack containing water-soluble polyurethane

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105188651A (en) * 2013-04-18 2015-12-23 C&Tech株式会社 Composition for hydrogel pack and mask pack using same
CN103520767A (en) * 2013-10-28 2014-01-22 山东赛克赛斯药业科技有限公司 Anti-microbial healing-promoting hydrogel dressing and preparation method therefor
CN105456056A (en) * 2014-12-10 2016-04-06 韩佛化妆品株式会社 Hydrogel composition for masking pack containing water-soluble polyurethane

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107412838A (en) * 2017-07-28 2017-12-01 威海洁瑞医用制品有限公司 Hydrocolloid and medical application containing vitamin E and 1,2 hexylene glycols and preparation method thereof
CN107868139A (en) * 2017-12-05 2018-04-03 青岛聚大洋藻业集团有限公司 The method that OIT makees bactericide processing algin
CN111481497A (en) * 2019-01-28 2020-08-04 北京万生人和科技有限公司 Hydrogel
CN110623792A (en) * 2019-09-23 2019-12-31 温州医科大学附属第一医院 Medical dressing and preparation method thereof
CN110623792B (en) * 2019-09-23 2022-05-06 温州医科大学附属第一医院 Medical dressing and preparation method thereof
CN110859701A (en) * 2019-12-02 2020-03-06 广东美贝健药业有限公司 Antibacterial gel antipyretic patch and preparation method thereof
CN112545934A (en) * 2020-12-10 2021-03-26 龙林平 Seabuckthorn fruit extract moisturizing gel and preparation method thereof
CN113456883A (en) * 2021-07-23 2021-10-01 绍兴百立康医疗科技有限公司 Cold compress anti-inflammation gel and preparation method thereof

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Application publication date: 20161116