CN114246976A - Hydrogel dressing for wound inflammation diminishing and preparation method thereof - Google Patents
Hydrogel dressing for wound inflammation diminishing and preparation method thereof Download PDFInfo
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- CN114246976A CN114246976A CN202111499781.XA CN202111499781A CN114246976A CN 114246976 A CN114246976 A CN 114246976A CN 202111499781 A CN202111499781 A CN 202111499781A CN 114246976 A CN114246976 A CN 114246976A
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- wound
- hydrogel
- hydrogel dressing
- inflammation
- ethanol
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 32
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 22
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 18
- 230000003467 diminishing effect Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims description 24
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 20
- 229920002401 polyacrylamide Polymers 0.000 claims description 19
- 239000011259 mixed solution Substances 0.000 claims description 17
- 229960005322 streptomycin Drugs 0.000 claims description 12
- 239000000499 gel Substances 0.000 claims description 11
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 10
- 229960004889 salicylic acid Drugs 0.000 claims description 10
- 230000003020 moisturizing effect Effects 0.000 claims description 7
- 239000002480 mineral oil Substances 0.000 claims description 5
- 235000010446 mineral oil Nutrition 0.000 claims description 5
- 239000008346 aqueous phase Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013589 supplement Substances 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 description 21
- 210000003491 skin Anatomy 0.000 description 18
- 210000000434 stratum corneum Anatomy 0.000 description 9
- 239000012071 phase Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 206010040882 skin lesion Diseases 0.000 description 3
- 231100000444 skin lesion Toxicity 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
Abstract
The invention discloses a hydrogel dressing for wound inflammation diminishing and a preparation method thereof. The hydrogel dressing has a pH value of 5-6, can be applied to a disinfected wound as a dressing, is used for preventing the wound from contacting with the external environment, can supplement water to the skin while preventing the wound from being inflamed, and keeps the skin breathable.
Description
Technical Field
The invention relates to the technical field of beauty medicine, in particular to a hydrogel dressing for wound inflammation diminishing and a preparation method thereof.
Background
The skin consists of several layers covering and protecting the cells of keratin and collagen fibrils that make up its structural skeleton, the outermost of these layers, called the stratum corneum, is known to be composed of 250A protein bundles surrounded by 80A thick layers. Anionic surfactants and organic solvents typically penetrate the stratum corneum membrane and disrupt its integrity by defatting (i.e., removing lipids from the stratum corneum). Disruption of the skin surface topography leads to a harsh feel and may eventually cause surfactants or solvents to contact the keratin, creating an irritating sensation. When the stratum corneum is destroyed, the exposed skin is easily repeatedly inflamed and can not be effectively healed if the antibacterial treatment is not carried out. At the same time, maintaining a proper moisture gradient across the stratum corneum is important to its function. A significant portion of this water comes from the body and is sometimes seen as a plasticizer for the stratum corneum. If the humidity is too low, like in cold climates, not enough water remains in the outer layers of the stratum corneum to properly plasticize the tissue, and the skin begins to peel and becomes itchy. The permeability of the skin also decreases to some extent when there is insufficient water to pass through the stratum corneum. On the other hand, too much water on the outer layers of the skin causes the stratum corneum to eventually absorb three to five times its own weight of bound water, which causes the skin to swell and wrinkle, resulting in about a two to three-fold increase in the skin's permeability to water and other polar molecules.
Disclosure of Invention
The invention aims to provide a hydrogel dressing for wound inflammation diminishing.
Yet another object of the present invention is to: provides a preparation method of the hydrogel dressing product for diminishing the inflammation of the wound.
The purpose of the invention is realized by the following scheme: the hydrogel dressing for diminishing inflammation of the wound is characterized in that hydrogel, streptomycin mixed liquid and skin moisturizing essence are combined to prepare the hydrogel dressing for diminishing inflammation of the wound.
The hydrogel is nonionic polyacrylamide.
The molecular weight of the nonionic polyacrylamide is 10,000,000-30,000,000.
Contains 0.5-1% of mixed solution of streptomycin.
The pH value is 5-6 but less than 6.
Contains 1-2% of skin moisturizing essence.
The invention provides a preparation method of a hydrogel dressing for wound inflammation diminishing, which is characterized in that 73 mL of water is added into a container with proper size, stirring is carried out at 300 rpm/min, simultaneously 15g of a mixture of 10,000,000-molecular-weight and 30,000,000-molecular-weight polyacrylamide, 5g of mineral oil and 1 mL of streptomycin are added into the water, 5 mL of ethanol is separately placed into another container and a cover is added, a mixer with three screw propellers is adopted, 1 mL of salicylic acid is added into the ethanol and mixed at 100 rpm/min until the salicylic acid is dissolved, the ethanol mixed solution is slowly added into a polyacrylamide water phase to form a gel, and the generated gel is mixed at a medium speed until the gel is uniform.
The invention adopts non-ionic polyacrylamide with molecular weight of 10,000,000-30,000,000 to prepare the hydrogel substrate, and simultaneously 0.5-1% of streptomycin mixed liquid is added to mix 1-2% of skin moisturizing essence.
The invention provides a hydrogel dressing for wound inflammation diminishing, wherein a high molecular weight hydrogel substrate material can be well coated on the surface of a wound, is not easy to fall off, and effectively prevents the wound from contacting with the environment. Meanwhile, the mixed solution of the streptomycin can effectively eliminate the original untreated clean bacteria on the surface of the skin. Finally, the skin moisturizing essence can effectively ensure the moisture gradient of the skin, so that the recovery of the wound is accelerated.
The invention discloses a hydrogel dressing for wound inflammation diminishing, which is prepared by reasonably matching preparations and is suitable for skin of each part. The hydrogel substrate in the formula can be well coated on the surface of the wound, so that the contact between the wound and the environment is effectively blocked. The mixed solution of the streptomycin can effectively eliminate the original untreated clean bacteria on the surface of the skin. The skin moisturizing essence can effectively ensure that the moisture of the skin cannot be lost. The invention uses the multi-component combined formula to improve the effect defect of a single product, directly acts the compound formula of the dressing on the corresponding layers of the main components, reduces the functional disorder of the single product and greatly improves the requirement of wound anti-inflammation.
Detailed Description
In order to more clearly and specifically illustrate the technical solution of the present invention, the present invention is further described by the following embodiments. The following examples are intended to illustrate the practice of the present invention and are not intended to limit the scope of the invention.
Example 1
A hydrogel dressing for wound inflammation diminishing is prepared by 0.5-1% of streptomycin mixed solution and 1-2% of skin moisturizing essence in hydrogel, wherein the hydrogel is nonionic polyacrylamide, and is prepared by the following steps:
adding 73 mL of water into a container with proper size, stirring at 300 rpm/min, and adding a mixed solution of 15g of nonionic polyacrylamide with the molecular weight of 10,000,000, 5g of mineral oil and 1 mL of streptomycin into the water to obtain a polyacrylamide water phase;
separately putting 5 mL of ethanol into another container, adding a cover, adding 1 mL of salicylic acid into the ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
the resulting ethanol mixed solution is slowly added to the polyacrylamide aqueous phase to form a gel having a pH of less than 6, preferably a pH of 5-6, and the resulting gel is mixed at a moderate rate until homogeneous.
Example 2
A hydrogel dressing for wound anti-inflammation, prepared by the following steps, similar to the steps of example 1:
adding 73 mL of water into a container with proper size, stirring at 300 rpm/min, and adding a mixed solution of 15g of non-ionic polyacrylamide with the molecular weight of 20,000,000, 5g of mineral oil and 1 mL of streptomycin into the water to obtain a polyacrylamide water phase;
separately putting 5 mL of ethanol into another container, adding a cover, adding 1 mL of salicylic acid into the ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
the resulting ethanol mixed solution is slowly added to the polyacrylamide aqueous phase to form a gel having a pH of less than 6, preferably a pH of 5-6, and the resulting gel is mixed at a moderate rate until homogeneous.
Example 3
A hydrogel dressing for wound anti-inflammation, prepared by the following steps, similar to the steps of example 1:
adding 73 mL of water into a container with proper size, stirring at 300 rpm/min, and adding a mixed solution of 15g of 30,000,000-molecular-weight nonionic polyacrylamide, 5g of mineral oil and 1 mL of streptomycin into the water to obtain a polyacrylamide water phase;
separately putting 5 mL of ethanol into another container, adding a cover, adding 1 mL of salicylic acid into the ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
the resulting ethanol mixed solution is slowly added to the polyacrylamide aqueous phase to form a gel having a pH of less than 6, preferably a pH of 5-6, and the resulting gel is mixed at a moderate rate until homogeneous.
Examples 1 to 3 effect test:
the three hydrogel dressings prepared in example 1/2/3 were applied to the wound sites of three mice of the same skin lesion model, respectively, and one control mouse was prepared without treatment of the wound site and was raised in cages for 15 days. In the feeding process, the skin lesion of the mouse coated with the hydrogel dressing is gradually healed on the fifth day, and meanwhile, no inflammation phenomenon occurs in the healing process. The skin lesions of the mice in the control group developed ulcers, and bacterial infection was inevitable.
Therefore, the hydrogel dressing disclosed by the invention has a very good help effect on wound recovery and inflammation diminishing.
The above-mentioned embodiments only express the specific embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (4)
1. The hydrogel dressing for wound inflammation diminishing is characterized in that hydrogel contains 0.5-1% of streptomycin mixed solution and 1-2% of skin moisturizing essence, and the hydrogel dressing for wound inflammation diminishing is prepared, wherein the hydrogel is nonionic polyacrylamide.
2. The hydrogel dressing for diminishing inflammation of a wound as claimed in claim 1, wherein the molecular weight of the non-ionic polyacrylamide is 10,000,000-30,000,000.
3. The hydrogel dressing for diminishing inflammation of a wound as claimed in claim 2, wherein the pH is less than 6 and is 5 to 6.
4. A method of manufacturing a hydrogel dressing for wound anti-inflammation according to any one of claims 1 to 3, comprising the steps of:
73 mL of water was added to the vessel and stirred at 300 rpm/min while 15g of a mixture of 10,000,000-molecular weight-modified 30,000,000 nonionic polyacrylamide, 5g of mineral oil and 1 mL of a mixture of streptomycin,
separately putting 5 mL of ethanol into another container, adding a cover, adding 1 mL of salicylic acid into the ethanol by adopting a mixer with three screw propellers, and mixing at 100 rpm/min until the salicylic acid is dissolved to obtain an ethanol mixed solution;
this ethanol mixed solution was slowly added to the polyacrylamide aqueous phase to form a gel, and the resulting gel was mixed at a moderate speed until homogeneous.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111499781.XA CN114246976A (en) | 2021-12-09 | 2021-12-09 | Hydrogel dressing for wound inflammation diminishing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111499781.XA CN114246976A (en) | 2021-12-09 | 2021-12-09 | Hydrogel dressing for wound inflammation diminishing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114246976A true CN114246976A (en) | 2022-03-29 |
Family
ID=80794346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111499781.XA Pending CN114246976A (en) | 2021-12-09 | 2021-12-09 | Hydrogel dressing for wound inflammation diminishing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114246976A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381735A (en) * | 2022-08-13 | 2022-11-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
| CN115487347A (en) * | 2022-09-22 | 2022-12-20 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for moisturizing, diminishing inflammation and removing acne of skin |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010055608A1 (en) * | 1999-05-18 | 2001-12-27 | Alan C. Hymes | Treating traumatic burns or blisters of the skin |
| CN103520767A (en) * | 2013-10-28 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | Anti-microbial healing-promoting hydrogel dressing and preparation method therefor |
| CN103623453A (en) * | 2013-12-06 | 2014-03-12 | 长春吉原生物科技有限公司 | Preparation method of silver ion hydrogel dressing |
| CN109966471A (en) * | 2015-08-28 | 2019-07-05 | 宇肽生物(东莞)有限公司 | A kind of peptide composition for skin repair |
| CN110522942A (en) * | 2019-10-16 | 2019-12-03 | 浙江星月生物科技股份有限公司 | A kind of preparation method of skin repair dressing and skin repair dressing |
| CN111437437A (en) * | 2020-06-02 | 2020-07-24 | 陈雨歆 | Polyacrylamide hydrogel dressing and preparation method and application thereof |
-
2021
- 2021-12-09 CN CN202111499781.XA patent/CN114246976A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010055608A1 (en) * | 1999-05-18 | 2001-12-27 | Alan C. Hymes | Treating traumatic burns or blisters of the skin |
| CN103520767A (en) * | 2013-10-28 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | Anti-microbial healing-promoting hydrogel dressing and preparation method therefor |
| CN103623453A (en) * | 2013-12-06 | 2014-03-12 | 长春吉原生物科技有限公司 | Preparation method of silver ion hydrogel dressing |
| CN109966471A (en) * | 2015-08-28 | 2019-07-05 | 宇肽生物(东莞)有限公司 | A kind of peptide composition for skin repair |
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| CN111437437A (en) * | 2020-06-02 | 2020-07-24 | 陈雨歆 | Polyacrylamide hydrogel dressing and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115381735A (en) * | 2022-08-13 | 2022-11-25 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for skin oxidation resistance and preparation method thereof |
| CN115487347A (en) * | 2022-09-22 | 2022-12-20 | 上海纳米技术及应用国家工程研究中心有限公司 | Hydrogel dressing for moisturizing, diminishing inflammation and removing acne of skin |
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